Lpar6 (lysophosphatidic acid receptor 6) - Rat Genome Database

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Gene: Lpar6 (lysophosphatidic acid receptor 6) Mus musculus
Analyze
Symbol: Lpar6
Name: lysophosphatidic acid receptor 6
RGD ID: 1617549
MGI Page MGI
Description: Predicted to enable lysophosphatidic acid receptor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in hypotrichosis 8. Orthologous to human LPAR6 (lysophosphatidic acid receptor 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610302I02Rik; LPA receptor 6; LPA-6; oleoyl-L-alpha-lysophosphatidic acid receptor; P2r; P2ry5; P2y; P2Y purinoceptor 5; P2y5; purinergic receptor (family A group 5); purinergic receptor 5; purinergic receptor P2Y, G-protein coupled, 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,475,331 - 73,477,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,475,335 - 73,480,734 (+)EnsemblGRCm39 Ensembl
GRCm381473,237,891 - 73,240,358 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,237,895 - 73,243,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv371473,637,698 - 73,640,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361471,972,050 - 71,974,497 (+)NCBIMGSCv36mm8
Celera1470,758,227 - 70,760,692 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
furan  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
mercury dibromide  (ISO)
methidathion  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenformin  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18023262  
PMID:18799693   PMID:21677750   PMID:21873635   PMID:22465231   PMID:24194600   PMID:24602016   PMID:26714589   PMID:26830463   PMID:27626380   PMID:27869233   PMID:28700664   PMID:28854359  
PMID:29778535   PMID:30804442   PMID:30847983   PMID:31335323   PMID:33317583   PMID:35074512   PMID:35151977   PMID:36153691  


Genomics

Comparative Map Data
Lpar6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,475,331 - 73,477,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,475,335 - 73,480,734 (+)EnsemblGRCm39 Ensembl
GRCm381473,237,891 - 73,240,358 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,237,895 - 73,243,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv371473,637,698 - 73,640,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361471,972,050 - 71,974,497 (+)NCBIMGSCv36mm8
Celera1470,758,227 - 70,760,692 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.75NCBI
LPAR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,389,571 - 48,444,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1348,389,567 - 48,444,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371348,985,274 - 49,018,805 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,883,182 - 47,887,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 341347,883,275 - 47,887,947NCBI
Celera1330,039,912 - 30,073,567 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1329,777,751 - 29,810,928 (-)NCBIHuRef
CHM1_11348,952,866 - 48,985,831 (-)NCBICHM1_1
T2T-CHM13v2.01347,609,888 - 47,664,937 (-)NCBIT2T-CHM13v2.0
Lpar6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81554,826,110 - 54,827,919 (+)NCBIGRCr8
mRatBN7.21548,416,548 - 48,418,357 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,416,544 - 48,422,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,557,397 - 52,559,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,668,972 - 53,670,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,514,212 - 50,516,021 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,126,953 - 55,128,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,126,953 - 55,128,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,850,070 - 58,851,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,875,463 - 53,877,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1548,066,078 - 48,067,887 (+)NCBICelera
Cytogenetic Map15q11NCBI
Lpar6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554312,077,269 - 2,078,300 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554312,077,093 - 2,079,000 (-)NCBIChiLan1.0ChiLan1.0
LPAR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21449,860,878 - 49,893,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11348,511,768 - 48,544,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01329,561,219 - 29,567,414 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11348,262,910 - 48,295,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1348,263,254 - 48,264,291 (-)Ensemblpanpan1.1panPan2
LPAR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,110,797 - 3,112,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,111,462 - 3,112,499 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,139,671 - 3,141,658 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0223,175,184 - 3,176,372 (+)NCBIROS_Cfam_1.0
Lpar6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,204,006 - 158,205,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365651,688,314 - 1,689,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365651,688,218 - 1,689,876 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,219,077 - 19,220,347 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,216,305 - 19,220,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,680,377 - 19,682,665 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LPAR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,332,770 - 26,335,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl326,333,023 - 26,334,054 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605717,570,804 - 17,573,633 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpar6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,423,861 - 6,424,892 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247486,423,170 - 6,425,149 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lpar6
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:169
Count of miRNA genes:138
Interacting mature miRNAs:152
Transcripts:ENSMUST00000044405
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470863768104863926Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1471221224105221344Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000044405   ⟹   ENSMUSP00000042327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1473,475,335 - 73,480,734 (+)Ensembl
GRCm38.p6 Ensembl1473,237,895 - 73,243,294 (+)Ensembl
RefSeq Acc Id: NM_175116   ⟹   NP_780325
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391473,475,331 - 73,477,798 (+)NCBI
GRCm381473,237,891 - 73,240,358 (+)ENTREZGENE
MGSCv371473,637,698 - 73,640,165 (+)RGD
Celera1470,758,227 - 70,760,692 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_780325   ⟸   NM_175116
- UniProtKB: A6H6N5 (UniProtKB/Swiss-Prot),   Q3TEJ6 (UniProtKB/Swiss-Prot),   Q8BMC0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000042327   ⟸   ENSMUST00000044405

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BMC0-F1-model_v2 AlphaFold Q8BMC0 1-344 view protein structure

Promoters
RGD ID:8682962
Promoter ID:EPDNEW_M19512
Type:initiation region
Name:Lpar6_1
Description:Mus musculus lysophosphatidic acid receptor 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381473,238,000 - 73,238,060EPDNEW
RGD ID:6825137
Promoter ID:MM_KWN:17430
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_175116,   NM_175116_LPAR6
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361473,637,741 - 73,639,297 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914418 AgrOrtholog
Ensembl Genes ENSMUSG00000033446 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044405 ENTREZGENE
  ENSMUST00000044405.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:67168 UniProtKB/Swiss-Prot
MGD MGI:1914418 ENTREZGENE
NCBI Gene 67168 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  LYSOPHOSPHATIDIC ACID RECEPTOR 6 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Lpar6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  P2Y5ORPHANR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6H6N5 ENTREZGENE
  LPAR6_MOUSE UniProtKB/Swiss-Prot
  Q3TEJ6 ENTREZGENE
  Q8BMC0 ENTREZGENE
UniProt Secondary A6H6N5 UniProtKB/Swiss-Prot
  Q3TEJ6 UniProtKB/Swiss-Prot