(-)-epigallocatechin 3-gallate multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PLAGL1 mRNA CTD PMID:22079256 (S)-colchicine increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Colchicine results in increased expression of PLAGL1 mRNA CTD PMID:20624997 1,1-dichloroethene decreases expression EXP 6480464 vinylidene chloride results in decreased expression of PLAGL1 mRNA CTD PMID:26682919 1,2-dichloroethane decreases expression EXP 6480464 ethylene dichloride results in decreased expression of PLAGL1 mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression EXP 6480464 1 and 2-Dimethylhydrazine results in decreased expression of PLAGL1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of PLAGL1 mRNA CTD PMID:17555576 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3',4,4',5-Pentachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLAGL1 mRNA CTD PMID:32109520 and PMID:33387578 2,3,7,8-Tetrachlorodibenzofuran decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:32109520 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:37080397 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of PLAGL1 mRNA CTD PMID:25172293 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol increases methylation EXP 6480464 bisphenol S results in increased methylation of PLAGL1 exon and bisphenol S results in increased methylation of PLAGL1 promoter CTD PMID:33297965 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of PLAGL1 mRNA CTD PMID:16467112 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of PLAGL1 mRNA CTD PMID:28973697 5-(hydroxymethyl)cytosine multiple interactions EXP 6480464 [bisphenol A results in increased methylation of PLAGL1 exon] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 5-aza-2'-deoxycytidine increases expression ISO PLAGL1 (Homo sapiens) 6480464 Decitabine results in increased expression of PLAGL1 mRNA CTD PMID:16367923 6-propyl-2-thiouracil increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of PLAGL1 mRNA CTD PMID:22504374 and PMID:24780913 aflatoxin B1 decreases methylation ISO PLAGL1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of PLAGL1 gene CTD PMID:27153756 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of PLAGL1 mRNA CTD PMID:17178593 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of PLAGL1 mRNA CTD PMID:16604517 all-trans-retinoic acid increases expression ISO PLAGL1 (Homo sapiens) 6480464 Tretinoin results in increased expression of PLAGL1 mRNA CTD PMID:21934132 and PMID:23724009 ammonium chloride affects expression ISO Plagl1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of PLAGL1 mRNA CTD PMID:16483693 aristolochic acid A decreases expression ISO PLAGL1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of PLAGL1 mRNA CTD PMID:33212167 Aroclor 1254 increases expression ISO PLAGL1 (Homo sapiens) 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of PLAGL1 mRNA CTD PMID:16934159 arsane affects methylation ISO PLAGL1 (Homo sapiens) 6480464 Arsenic affects the methylation of PLAGL1 gene CTD PMID:25304211 arsenic atom affects methylation ISO PLAGL1 (Homo sapiens) 6480464 Arsenic affects the methylation of PLAGL1 gene CTD PMID:25304211 benzo[a]pyrene affects methylation ISO PLAGL1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of PLAGL1 5' UTR and Benzo(a)pyrene affects the methylation of PLAGL1 promoter CTD PMID:27901495 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PLAGL1 mRNA CTD PMID:32417428 benzo[a]pyrene diol epoxide I decreases expression ISO PLAGL1 (Homo sapiens) 6480464 7 more ... CTD PMID:20018196 Benzo[k]fluoranthene decreases expression EXP 6480464 benzo(k)fluoranthene results in decreased expression of PLAGL1 mRNA CTD PMID:26377693 bexarotene decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 bexarotene results in decreased expression of PLAGL1 mRNA CTD PMID:16648578 bisphenol A affects expression ISO Plagl1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of PLAGL1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO PLAGL1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of PLAGL1 mRNA CTD PMID:36232920 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PLAGL1 mRNA CTD PMID:32156529 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PLAGL1 mRNA CTD PMID:35598803 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of PLAGL1 exon CTD PMID:30073950 bisphenol A multiple interactions EXP 6480464 [bisphenol A results in increased methylation of PLAGL1 exon] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of PLAGL1 exon CTD PMID:30044229 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PLAGL1 intron and bisphenol A results in increased methylation of PLAGL1 promoter CTD PMID:30044229 and PMID:30073950 bisphenol A decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of PLAGL1 mRNA CTD PMID:30816183 more ... bisphenol F multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA CTD PMID:28628672 buta-1,3-diene decreases expression EXP 6480464 1 and 3-butadiene results in decreased expression of PLAGL1 mRNA CTD PMID:29038090 C60 fullerene decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 fullerene C60 results in decreased expression of PLAGL1 mRNA CTD PMID:19167457 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLAGL1 mRNA CTD PMID:36200916 cadmium atom multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PLAGL1 mRNA CTD PMID:35301059 cadmium dichloride decreases methylation ISO Plagl1 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased methylation of PLAGL1 promoter CTD PMID:22457795 cadmium dichloride multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PLAGL1 mRNA CTD PMID:35301059 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLAGL1 mRNA CTD PMID:36200916 cadmium dichloride decreases expression ISO PLAGL1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of PLAGL1 mRNA CTD PMID:26472689 carbamazepine affects expression ISO PLAGL1 (Homo sapiens) 6480464 Carbamazepine affects the expression of PLAGL1 mRNA CTD PMID:25979313 carbon nanotube decreases expression EXP 6480464 Nanotubes more ... CTD PMID:25554681 CGP 52608 multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to PLAGL1 gene] CTD PMID:28238834 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of PLAGL1 mRNA CTD PMID:37019170 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAGL1 mRNA CTD PMID:20938992 cobalt dichloride increases expression ISO PLAGL1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of PLAGL1 mRNA CTD PMID:19376846 cocaine increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Cocaine results in increased expression of PLAGL1 mRNA CTD PMID:27899881 coumarin increases phosphorylation ISO PLAGL1 (Homo sapiens) 6480464 coumarin results in increased phosphorylation of PLAGL1 protein CTD PMID:35688186 crocidolite asbestos affects expression ISO PLAGL1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of PLAGL1 mRNA CTD PMID:17331233 crocidolite asbestos decreases expression EXP 6480464 Asbestos and Crocidolite results in decreased expression of PLAGL1 mRNA CTD PMID:29279043 CU-O LINKAGE decreases expression ISO PLAGL1 (Homo sapiens) 6480464 cupric oxide results in decreased expression of PLAGL1 mRNA CTD PMID:22077320 Cuprizon increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Cuprizone results in increased expression of PLAGL1 mRNA CTD PMID:26577399 and PMID:27523638 cyclosporin A decreases expression ISO PLAGL1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of PLAGL1 mRNA CTD PMID:25562108 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of PLAGL1 mRNA CTD PMID:17178593 dexamethasone multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA CTD PMID:28628672 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PLAGL1 mRNA CTD PMID:21266533 dimethylarsinic acid decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Cacodylic Acid results in decreased expression of PLAGL1 mRNA CTD PMID:37567419 dorsomorphin multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 ethyl methanesulfonate decreases expression ISO PLAGL1 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in decreased expression of PLAGL1 mRNA CTD PMID:23649840 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAGL1 mRNA CTD PMID:20938992 folic acid decreases expression EXP 6480464 Folic Acid results in decreased expression of PLAGL1 mRNA CTD PMID:25629700 gentamycin decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of PLAGL1 mRNA CTD PMID:33387578 geraniol increases expression ISO PLAGL1 (Homo sapiens) 6480464 geraniol results in increased expression of PLAGL1 mRNA CTD PMID:27683099 glucose decreases expression EXP 6480464 Glucose results in decreased expression of PLAGL1 mRNA CTD PMID:17178593 indometacin multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA CTD PMID:28628672 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of PLAGL1 mRNA CTD PMID:20003209 kojic acid increases expression ISO PLAGL1 (Homo sapiens) 6480464 kojic acid results in increased expression of PLAGL1 mRNA CTD PMID:16595896 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAGL1 mRNA CTD PMID:20938992 lead diacetate decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 lead acetate results in decreased expression of PLAGL1 mRNA CTD PMID:22641619 lead(0) increases methylation ISO PLAGL1 (Homo sapiens) 6480464 Lead results in increased methylation of PLAGL1 gene CTD PMID:26115033 levonorgestrel multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PLAGL1 mRNA CTD PMID:19074003 lithium chloride decreases expression ISO PLAGL1 (Homo sapiens) 6480464 Lithium Chloride results in decreased expression of PLAGL1 mRNA CTD PMID:23527032 methamphetamine multiple interactions ISO Plagl1 (Rattus norvegicus) 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of PLAGL1 mRNA CTD PMID:19564919 methamphetamine increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Methamphetamine results in increased expression of PLAGL1 mRNA CTD PMID:19564919 methimazole increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Methimazole results in increased expression of PLAGL1 mRNA CTD PMID:22504374 methotrexate increases expression ISO PLAGL1 (Homo sapiens) 6480464 Methotrexate results in increased expression of PLAGL1 mRNA CTD PMID:21678067 methoxychlor affects methylation ISO Plagl1 (Rattus norvegicus) 6480464 Methoxychlor affects the methylation of PLAGL1 gene CTD PMID:35440735 methylmercury chloride increases expression ISO PLAGL1 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of PLAGL1 mRNA CTD PMID:23179753 mitoxantrone affects response to substance ISO PLAGL1 (Homo sapiens) 6480464 PLAGL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of PLAGL1 mRNA CTD PMID:22078008 N-methyl-4-phenylpyridinium increases expression ISO Plagl1 (Rattus norvegicus) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PLAGL1 mRNA CTD PMID:28801915 nickel dichloride decreases expression EXP 6480464 nickel chloride results in decreased expression of PLAGL1 mRNA CTD PMID:12839937 nickel dichloride affects expression ISO Plagl1 (Rattus norvegicus) 6480464 nickel chloride affects the expression of PLAGL1 mRNA CTD PMID:22546817 nickel sulfate decreases expression EXP 6480464 nickel sulfate results in decreased expression of PLAGL1 mRNA CTD PMID:16166746 nickel sulfate decreases expression ISO PLAGL1 (Homo sapiens) 6480464 nickel sulfate results in decreased expression of PLAGL1 mRNA CTD PMID:22714537 oxaliplatin multiple interactions ISO Plagl1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PLAGL1 mRNA CTD PMID:25729387 oxaliplatin increases expression ISO Plagl1 (Rattus norvegicus) 6480464 oxaliplatin results in increased expression of PLAGL1 mRNA CTD PMID:25729387 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of PLAGL1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of PLAGL1 mRNA CTD PMID:33387578 paracetamol affects expression ISO PLAGL1 (Homo sapiens) 6480464 Acetaminophen affects the expression of PLAGL1 mRNA CTD PMID:25458485 PCB138 multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 phenylmercury acetate increases expression ISO PLAGL1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of PLAGL1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAGL1 mRNA CTD PMID:27188386 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PLAGL1 mRNA CTD PMID:16985257 pirinixic acid increases expression ISO Plagl1 (Rattus norvegicus) 6480464 pirinixic acid results in increased expression of PLAGL1 mRNA CTD PMID:12832660 potassium chromate increases expression ISO PLAGL1 (Homo sapiens) 6480464 potassium chromate(VI) results in increased expression of PLAGL1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PLAGL1 mRNA CTD PMID:22079256 quercetin increases expression ISO PLAGL1 (Homo sapiens) 6480464 Quercetin results in increased expression of PLAGL1 mRNA CTD PMID:21632981 riboflavin affects expression ISO PLAGL1 (Homo sapiens) 6480464 Riboflavin affects the expression of PLAGL1 CTD PMID:16109485 SB 431542 multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SCH 23390 multiple interactions ISO Plagl1 (Rattus norvegicus) 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of PLAGL1 mRNA CTD PMID:19564919 sodium arsenite decreases expression ISO PLAGL1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of PLAGL1 mRNA CTD PMID:22714537 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of PLAGL1 mRNA CTD PMID:17555576 tert-butyl hydroperoxide increases expression ISO PLAGL1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of PLAGL1 mRNA CTD PMID:15336504 Testosterone propionate decreases expression EXP 6480464 Testosterone Propionate results in decreased expression of PLAGL1 mRNA CTD PMID:15601916 testosterone undecanoate multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PLAGL1 mRNA CTD PMID:19074003 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of PLAGL1 mRNA CTD PMID:17484886 tetrachloromethane decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of PLAGL1 mRNA CTD PMID:16239168 topotecan increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Topotecan results in increased expression of PLAGL1 mRNA CTD PMID:25729387 topotecan multiple interactions ISO Plagl1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PLAGL1 mRNA CTD PMID:25729387 Trapidil multiple interactions ISO Plagl1 (Rattus norvegicus) 6480464 Trapidil affects the reaction [PTH protein affects the expression of PLAGL1 mRNA] CTD PMID:18635661 Tributyltin oxide increases expression EXP 6480464 bis(tri-n-butyltin)oxide results in increased expression of PLAGL1 mRNA CTD PMID:18958704 trichloroethene increases methylation ISO Plagl1 (Rattus norvegicus) 6480464 Trichloroethylene results in increased methylation of PLAGL1 gene CTD PMID:27618143 trichloroethene decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of PLAGL1 mRNA CTD PMID:33387578 trichostatin A decreases expression ISO PLAGL1 (Homo sapiens) 6480464 trichostatin A results in decreased expression of PLAGL1 mRNA CTD PMID:24935251 and PMID:26272509 trichostatin A multiple interactions ISO PLAGL1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAGL1 mRNA CTD PMID:27188386 triptonide increases expression EXP 6480464 triptonide results in increased expression of PLAGL1 mRNA CTD PMID:33045310 urethane increases expression ISO PLAGL1 (Homo sapiens) 6480464 Urethane results in increased expression of PLAGL1 mRNA CTD PMID:28818685 valproic acid decreases methylation ISO PLAGL1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of PLAGL1 gene CTD PMID:29154799 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PLAGL1 mRNA CTD PMID:24896083 valproic acid increases expression ISO PLAGL1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of PLAGL1 mRNA CTD PMID:19101580 and PMID:24935251 vincaleukoblastine increases expression ISO Plagl1 (Rattus norvegicus) 6480464 Vinblastine results in increased expression of PLAGL1 mRNA CTD PMID:20624997 vitamin E decreases expression ISO PLAGL1 (Homo sapiens) 6480464 Vitamin E results in decreased expression of PLAGL1 mRNA CTD PMID:19244175 vorinostat decreases expression ISO PLAGL1 (Homo sapiens) 6480464 vorinostat results in decreased expression of PLAGL1 mRNA CTD PMID:27188386 zinc atom decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of PLAGL1 mRNA CTD PMID:19111725 zinc(0) decreases expression ISO Plagl1 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of PLAGL1 mRNA CTD PMID:19111725