Gene: Tlr4 (toll-like receptor 4)  Mus musculus Symbol: Tlr4 Name: toll-like receptor 4 Description: ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); lipopolysaccharide receptor activity (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN activation of innate immune response; activation of MAPK activity; B cell proliferation involved in immune response; PARTICIPATES IN Toll-like receptor signaling pathway; Entamoeba histolyca infection pathway; influenza A virus infection pathway; ASSOCIATED WITH abnormal acute inflammation; abnormal airway responsiveness; abnormal artery morphology; ASSOCIATED WITH Acute Kidney Injury; Acute Tubulointerstitial Nephritis; Amoebiasis due to Entamoeba histolytica; FOUND IN cell surface (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH 1,4-dithiothreitol; 1-chloro-2,4,6-trinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine Type: protein-coding RefSeq Status: PROVISIONAL Also known as: lipopolysaccharide response; Lps; Ly87; OTTMUSP00000000296; Ran/M1; Rasl2-8; toll-like receptor 4 Orthologs: Homo sapiens : TLR4 (toll-like receptor 4)  HGNC Rattus norvegicus : Tlr4 (toll-like receptor 4) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,827,811 - 66,842,797 + NCBI Mouse cM Map 4 34.66   NCBI Mouse Celera Assembly 4 65,431,141 - 65,446,127 + NCBI Mouse Genome Assembly Build 37 4 66,488,845 - 66,503,831 + NCBI Mouse Genome Assembly Build 36.1 4 66,488,845 - 66,503,831 + NCBI Mouse Cytogenetic Map 4 C1   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   IEP   7241084   RGD   Acute Kidney Injury Treatment ISS RGD:3870 6892690   RGD   Acute Kidney Injury   IPM   7207898 associated with Sepsis RGD   Acute Lung Injury   ISS RGD:3870 5135496   RGD   Acute Tubulointerstitial Nephritis   IPM   7207900   RGD   Alzheimer Disease   ISS RGD:737013 1580680   RGD   Amoebiasis due to Entamoeba histolytica   IPM   7241086   RGD   Arteriosclerosis Susceptibility ISS RGD:737013 1624159 DNA:SNP: :c.896A>G (human) RGD   Asthma   ISS RGD:737013 4144171 DNA:SNPs:: RGD   Asthma Severity ISS RGD:737013 4144198 DNA:polymorphisms:cds:c.896A>G, 1196C>T (human) RGD   Asthma Susceptibility ISS RGD:737013 4144817 DNA:Polymorphism:cds:p.D299G (human) RGD   Asthma No_Association ISS RGD:737013 4144188 DNA:SNPs: :rs10983755, rs1927914 (human) RGD   Asthma   ISS RGD:737013 4144190 protein:decreased expression:leukocytes, mononuclear RGD   Asthma   IPM   4144141   RGD   Asthma   IED   4144176   RGD   Bacteremia Susceptibility ISS RGD:737013 4144194 DNA:polymorphisms:cds:p.D299G, T399I (human) RGD   Brain Injuries   ISS RGD:3870 2312713 mRNA:increased expression:brain RGD   Brain Ischemia No_Association ISS RGD:737013 1580737 DNA:polymorphisms: :p.N299G, p.T399I (human) RGD   Bronchial Hyperreactivity   IPM   4144229   RGD   Bronchiolitis, Viral   ISS RGD:737013 4144819 protein:increased expression:monocyte RGD   Bronchiolitis, Viral   ISS RGD:737013 4144183 protein:decreased expression:neutrophil RGD   Carotid Artery Diseases   ISS RGD:737013 1580737   RGD   Carotid Stenosis Treatment ISS RGD:3870 7241095   RGD   Colitis   ISS RGD:3870 2312573 protein:increased expression:colon RGD   Colorectal Neoplasms   ISS RGD:737013 7240710   OMIM   Coronary Artery Disease   ISS RGD:737013 1580736   RGD   Cystic Fibrosis Severity IPM   4144179   RGD   Cystic Fibrosis   ISS RGD:737013 4144105 protein:increased expression:monocyte RGD   Diabetes Mellitus   ISS RGD:737013 2312485 protein:increased expression:monocyte RGD   Diabetes Mellitus   ISS RGD:737013 1580736   RGD   Diabetes Mellitus, Experimental   ISS RGD:3870 2312491   RGD   Diabetes Mellitus, Type 1   ISS RGD:737013 2312683 protein:increased expression:monocyte RGD   Diabetes Mellitus, Type 1   IEP   2312492   RGD   Diabetes Mellitus, Type 2 No_Association ISS RGD:737013 2312494 DNA:polymorphisms: :p.N299G, p.T399I (human) RGD   Diabetes Mellitus, Type 2   ISS RGD:737014 2312680 protein:increased expression:monocyte RGD   Diabetes Mellitus, Type 2   IEP   2312492   RGD   Diabetes Mellitus, Type 2   ISS RGD:737013 2312484 DNA:polymorphisms: :p.N299G, p.T399I (human) RGD   Diabetic Nephropathies   IPM   7207902 associated with Diabetes Mellitus, Experimental RGD   Diabetic Neuropathies Susceptibility ISS RGD:737013 2312493 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms: :p.N299G, p.T399I (human) RGD   Diabetic Retinopathy Onset ISS RGD:737013 2312487 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.N299G (human) RGD   Encephalomyelitis, Autoimmune, Experimental   ISS RGD:3870 2312575 protein:increased expression:spinal cord RGD   Endotoxemia Treatment ISS RGD:3870 7241094   RGD   Enterocolitis, Necrotizing   ISS RGD:3870 5128779 mRNA:increased expression:ileum RGD   Enterocolitis, Necrotizing   ISS RGD:3870 5490305 protein:increased expression:ileum RGD   Eye Infections, Fungal   ISS RGD:3870 2312502 mRNA:increased expression:cornea RGD   Glomerulonephritis   IPM   4144104   RGD   Glomerulonephritis   IED   7241071   RGD   Hepatorenal Syndrome   ISS RGD:3870 4144102 mRNA, protein:increased expression:kidney RGD   Hyperalgesia   ISS RGD:3870 4144070   RGD   Hypertension, Pulmonary   IPM   4144108 associated with anoxia RGD   Ileitis   IPM   7241089   RGD   Insulin Resistance   IAGP   2312483 associated with Obesity RGD   Insulin Resistance Severity ISS RGD:737013 2312489 protein:increased expression:skeletal muscle RGD   Insulin Resistance   IAGP   1620681   RGD   Kidney Failure, Chronic   ISS RGD:737013 7240546   RGD   Kidney Reperfusion Injury   IPM   7240552   RGD   Kidney Reperfusion Injury Treatment ISS RGD:3870 7207892   RGD   Kidney Reperfusion Injury   IEP   7241087   RGD   Leptospirosis   IPM   7240557   RGD   Leptospirosis   IPM   7241090   RGD   Liver Cirrhosis, Experimental Treatment ISS RGD:3870 7241092   RGD   Liver Failure, Acute   ISS RGD:3870 4144156 mRNA:increased expression:liver RGD   Lung Diseases   IPM   4144143 lung injury associated with pancreatitis; RGD   Lung Diseases   ISS RGD:3870 4144082 Acute Lung Injury; more ... RGD   Lung Diseases   ISS RGD:3870 5128779   RGD   Lung Diseases   IPM   4143249 ventilator-induced lung injury RGD   Lung Diseases   IPM   4144789 acute lung injury RGD   Lung Diseases   ISS RGD:3870 2312725 associated with Pancreatitis, Acute Necrotizing RGD   Lung Diseases   IEP   4144149 acute lung injury associated with Hemorrhagic shock; more ... RGD   Lupus Erythematosus, Systemic   IPM   7241088   RGD   Macular Degeneration   ISS RGD:737013 7240710   OMIM   Macular Degeneration, Age-Related, 10   ISS RGD:737013 7240710   OMIM   Multiple Sclerosis   ISS RGD:737013 2312575 mRNA:increased expression:cerebrospinal fluid, mononuclear cell RGD   Myocardial Infarction   ISS RGD:737013 5562819 DNA:SNP:intron:rs1927911, minor allele associated with decreased risk (human) RGD   Myocardial Infarction   ISS RGD:737013 1580734   RGD   Myocardial Reperfusion Injury   ISS RGD:3870 1302746   RGD   Neuralgia   ISS 3870 1342461 mRNA:increased expression:lumbar vertebra RGD   Neuritis, Autoimmune, Experimental   ISS RGD:3870 2312677 mRNA:increased expression:multiple tissues RGD   Obesity   IAGP   2312510   RGD   Obesity Susceptibility IAGP   1620653   RGD   Obesity   ISS RGD:3870 2312510   RGD   Pain   ISS RGD:3870 2312574   RGD   Pancreatitis   IPM   4144143   RGD   Pancreatitis   ISS RGD:3870 2312507   RGD   Pancreatitis, Acute Necrotizing   ISS RGD:3870 2312724 mRNA:increased expression:liver RGD   Pneumonia   IPM   4142858   RGD   Pneumonia, Bacterial   IPM   4144197   RGD   Pneumonia, Bacterial   IPM   4144172   RGD   Pre-Eclampsia   ISS RGD:737013 1580682   RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:737013 4144145 decreased expression:protein:monocyte RGD   Pulmonary Disease, Chronic Obstructive Susceptibility ISS RGD:737013 4144119 DNA:polymorphism:blood cells RGD   Pulmonary Edema   IPM   4144136 associated with reperfusion injury RGD   Pulmonary Emphysema   IPM   4144170   RGD   Pulmonary Fibrosis   IPM   4144177   RGD   Pulmonary Fibrosis   IPM   4144120 associated with acute lung injury RGD   Renal Fibrosis   ISS RGD:3870 7207895 associated with Ureteral Obstruction RGD   Renal Insufficiency   ISS RGD:3870 7241085   RGD   Reperfusion Injury   ISS RGD:3870 2312503 protein:increased expression:liver RGD   Reperfusion Injury   IPM   4144169   RGD   Respiratory Hypersensitivity   ISS RGD:737013 7240710   OMIM   Respiratory Syncytial Virus Infections No_Association ISS RGD:737013 4144164 DNA:SNP:cds:p.D299G (human) RGD   Respiratory Syncytial Virus Infections   IPM   4889534   RGD   Respiratory Syncytial Virus Infections Susceptibility ISS RGD:737013 4144167 DNA:polymorphisms:cds:p.D259G, T359I (human) RGD   Respiratory Syncytial Virus Infections   ISS RGD:737013 4144161 DNA:SNPs:cds:p.D299G, T399I (human) RGD   Rhinitis, Allergic, Seasonal Susceptibility ISS RGD:737013 4144192 DNA:polymorphisms:cds:p.D299G, T399I (human) RGD   Sepsis   ISS RGD:3870 2312732   RGD   Sepsis   ISS RGD:3870 2312497 associated with Sepsis;mRNA:increased expression:liver RGD   Subarachnoid Hemorrhage   ISS RGD:3870 4144093 mRNA, protein:increased expression:brain RGD   Transplant Rejection   IPM   7240555   RGD   Transplant Rejection   IPM   7240548 pancreatic islet RGD   Tuberculosis   IPM   4144821   RGD   Tuberculosis, Pleural   ISS RGD:737013 4144193   RGD   Tuberculosis, Pulmonary Susceptibility ISS RGD:737013 4144122 DNA:SNP:intron: rs5030729 (human) RGD   Tuberculosis, Pulmonary   ISS RGD:737013 4144205 protein:increased expression:monocyte RGD   Tuberculosis, Pulmonary Severity ISS RGD:737013 4144106 DNA:polymorphisms:cds: p. D299F, T399I (human) RGD   Urinary Bladder Neoplasms Treatment IPM   7240556   RGD   Uveitis   ISS RGD:3870 2312506 protein:increased expression:iris RGD   Wallerian Degeneration   IAGP   2312723   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) 1,4-dithiothreitol multiple interactions EXP   6480464 Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; more ... CTD PMID:19627980 1-chloro-2,4,6-trinitrobenzene multiple interactions EXP   6480464 TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride] CTD PMID:18725520 1-chloro-2,4,6-trinitrobenzene increases response to substance EXP   6480464 TLR4 protein results in increased susceptibility to Picryl Chloride CTD PMID:18725520 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:737013 6480464 bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]]; more ... CTD PMID:16317058 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA; more ... CTD PMID:21097750 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Fish Oils inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TLR4 mRNA] CTD PMID:21653731 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of TLR4 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:3870 6480464 Tetrachlorodibenzodioxin affects the expression of TLR4 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of TLR4 mRNA CTD PMID:21093581 PMID:21653731 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of TLR4 mRNA CTD PMID:21093581 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:737013 6480464 3,4,5,3',4'-pentachlorobiphenyl affects the expression of TLR4 mRNA CTD PMID:21703328 4-hydroxynon-2-enal multiple interactions ISO RGD:737013 6480464 4-hydroxy-2-nonenal inhibits the reaction [TLR4 protein binds to TLR4 protein] CTD PMID:19627980 4-hydroxynon-2-enal decreases activity ISO RGD:737013 6480464 4-hydroxy-2-nonenal results in decreased activity of TLR4 protein CTD PMID:19627980 4-hydroxynon-2-enal multiple interactions EXP   6480464 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; more ... CTD PMID:19627980 adenosine increases expression ISO RGD:737013 6480464 Adenosine results in increased expression of TLR4 mRNA CTD PMID:21538184 adenosine affects localization ISO RGD:737013 6480464 Adenosine affects the localization of TLR4 protein CTD PMID:21538184 adenosine multiple interactions ISO RGD:737013 6480464 Adenosine promotes the reaction [lipopolysaccharide, E. coli 026-B6 affects the localization of TLR4 protein] CTD PMID:21538184 aflatoxin B1 increases expression ISO RGD:737013 6480464 Aflatoxin B1 results in increased expression of TLR4 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression ISO RGD:737013 6480464 Tretinoin results in increased expression of TLR4 mRNA CTD PMID:21934132 all-trans-retinol increases expression ISO RGD:737013 6480464 Vitamin A results in increased expression of TLR4 mRNA CTD PMID:17033190 aluminium hydroxide multiple interactions EXP   6480464 TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]; more ... CTD PMID:22075093 ammonium chloride affects expression ISO RGD:3870 6480464 Ammonium Chloride affects the expression of TLR4 mRNA CTD PMID:16483693 arsenic atom increases expression ISO RGD:737013 6480464 Arsenic results in increased expression of TLR4 mRNA CTD PMID:19945496 arsenite(3-) decreases expression EXP   6480464 arsenite results in decreased expression of TLR4 mRNA CTD PMID:18191166 auranofin multiple interactions EXP   6480464 Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:17034761 baicalin decreases expression ISO RGD:3870 6480464 baicalin results in decreased expression of TLR4 protein CTD PMID:22019745 benazepril decreases expression ISO RGD:737013 6480464 benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of TLR4 mRNA CTD PMID:22228805 berberine multiple interactions EXP   6480464 Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:21963898 bicalutamide multiple interactions ISO RGD:737013 6480464 bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]] CTD PMID:16317058 bis(2-chloroethyl) sulfide increases expression EXP   6480464 Mustard Gas results in increased expression of TLR4 mRNA CTD PMID:18955075 bisdemethoxycurcumin multiple interactions ISO RGD:737013 6480464 [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR4 mRNA; more ... CTD PMID:22029407 capsaicin increases expression ISO RGD:3870 6480464 Capsaicin results in increased expression of TLR4 protein CTD PMID:22150557 capsaicin multiple interactions ISO RGD:3870 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; more ... CTD PMID:22150557 carbamazepine increases expression EXP   6480464 Carbamazepine results in increased expression of TLR4 mRNA CTD PMID:22790970 cerium trichloride increases expression EXP   6480464 cerous chloride results in increased expression of TLR4 mRNA; more ... CTD PMID:21656643 chitosan decreases expression ISO RGD:737013 6480464 Chitosan results in decreased expression of TLR4 mRNA CTD PMID:21329777 chitosan multiple interactions ISO RGD:737013 6480464 Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA] CTD PMID:21329777 chlorogenic acid multiple interactions ISO RGD:3870 6480464 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; more ... CTD PMID:23146752 choline multiple interactions EXP   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR4 mRNA CTD PMID:20938992 chromium atom decreases expression ISO RGD:737013 6480464 Chromium results in decreased expression of TLR4 mRNA CTD PMID:21437242 cisplatin multiple interactions EXP   6480464 [Cisplatin co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein; more ... CTD PMID:21148032 cisplatin increases expression EXP   6480464 Cisplatin results in increased expression of TLR4 protein; more ... CTD PMID:21148032 cortisol decreases expression ISO RGD:737013 6480464 Hydrocortisone results in decreased expression of TLR4 mRNA CTD PMID:17033190 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; more ... CTD PMID:16678799 curcumin multiple interactions ISO RGD:3870 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; more ... CTD PMID:22683883 curcumin decreases expression ISO RGD:3870 6480464 Curcumin results in decreased expression of TLR4 protein; more ... CTD PMID:17965732 D-glucose decreases expression ISO RGD:737013 6480464 Glucose results in decreased expression of TLR4 protein CTD PMID:20200188 D-glucose multiple interactions EXP   6480464 TLR4 affects the reaction [lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; more ... CTD PMID:22558381 daunorubicin decreases response to substance EXP   6480464 TLR4 protein results in decreased susceptibility to Daunorubicin CTD PMID:18789402 dexamethasone increases expression ISO RGD:737013 6480464 Dexamethasone results in increased expression of TLR4 mRNA CTD PMID:19853017 dextran sulfate multiple interactions EXP   6480464 Lipopolysaccharides inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein] CTD PMID:21359540 dextran sulfate increases expression EXP   6480464 Dextran Sulfate results in increased expression of TLR4 protein CTD PMID:21359540 diazinon multiple interactions EXP   6480464 [TLR4 protein mutant form results in increased susceptibility to Diazinon] which results in decreased expression of BDNF mRNA; more ... CTD PMID:22428454 diazinon increases response to substance EXP   6480464 TLR4 protein mutant form results in increased susceptibility to Diazinon CTD PMID:22428454 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of TLR4 mRNA CTD PMID:20003209 dienogest multiple interactions ISO RGD:737013 6480464 dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 dioxygen increases expression ISO RGD:3870 6480464 Oxygen deficiency results in increased expression of TLR4 mRNA CTD PMID:23082119 dioxygen multiple interactions ISO RGD:3870 6480464 prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides promotes the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA]]; more ... CTD PMID:23082119 doxorubicin multiple interactions EXP   6480464 TLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; more ... CTD PMID:18321777 doxorubicin affects response to substance EXP   6480464 TLR4 protein affects the susceptibility to Doxorubicin CTD PMID:18321777 enalapril multiple interactions ISO RGD:737013 6480464 [atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; more ... CTD PMID:20524934 ethanol multiple interactions EXP   6480464 [Ethanol co-treated with isopentyl alcohol] promotes the reaction [TLR4 results in increased susceptibility to Acetaminophen] CTD PMID:16439473 ethanol increases expression ISO RGD:3870 6480464 Ethanol results in increased expression of TLR4 protein CTD PMID:22525864 ethanol multiple interactions ISO RGD:3870 6480464 Plant Extracts inhibits the reaction [Ethanol results in increased expression of TLR4 protein] CTD PMID:22525864 ethanol multiple interactions ISO RGD:3870 6480464 ADIPOQ protein inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:20861358 ethanol increases expression ISO RGD:3870 6480464 Ethanol results in increased expression of TLR4 mRNA CTD PMID:20861358 ethanol increases response to substance EXP   6480464 TLR4 results in increased susceptibility to Ethanol CTD PMID:16439473 eugenol increases expression ISO RGD:737013 6480464 Eugenol results in increased expression of TLR4 mRNA CTD PMID:17936526 ferulic acid multiple interactions EXP   6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; more ... CTD PMID:21291945 folic acid multiple interactions EXP   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR4 mRNA CTD PMID:20938992 glucose decreases expression ISO RGD:737013 6480464 Glucose results in decreased expression of TLR4 protein CTD PMID:20200188 glucose multiple interactions EXP   6480464 TLR4 affects the reaction [lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; more ... CTD PMID:22558381 glutathione decreases expression ISO RGD:737013 6480464 Glutathione results in decreased expression of TLR4 mRNA CTD PMID:22385246 GM1 ganglioside decreases expression ISO RGD:3870 6480464 G(M1) Ganglioside results in decreased expression of TLR4 protein CTD PMID:16651628 halothane multiple interactions EXP   6480464 TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 indomethacin multiple interactions EXP   6480464 TLR4 protein affects the reaction [Indomethacin results in decreased activity of CYP1A2 protein]; more ... CTD PMID:12927920 isoamylol multiple interactions EXP   6480464 [Ethanol co-treated with isopentyl alcohol] promotes the reaction [TLR4 results in increased susceptibility to Acetaminophen] CTD PMID:16439473 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of TLR4 mRNA CTD PMID:20003209 ketamine multiple interactions EXP   6480464 TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; more ... CTD PMID:19540866 L-methionine multiple interactions EXP   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR4 mRNA CTD PMID:20938992 lycopene multiple interactions ISO RGD:737013 6480464 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; more ... CTD PMID:22429818 magnesium dihydroxide multiple interactions EXP   6480464 TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]; more ... CTD PMID:22075093 melphalan decreases expression ISO RGD:737013 6480464 Melphalan results in decreased expression of TLR4 mRNA CTD PMID:22363485 methadone affects binding ISO RGD:737013 6480464 Methadone binds to TLR4 protein CTD PMID:20178837 methadone increases expression ISO RGD:3870 6480464 Methadone results in increased expression of TLR4 protein; more ... CTD PMID:20178837 methadone affects response to substance ISO RGD:3870 6480464 Methadone affects the susceptibility to TLR4 protein CTD PMID:20178837 methadone multiple interactions ISO RGD:737013 6480464 Naloxone affects the reaction [Methadone binds to TLR4 protein] CTD PMID:20178837 methotrexate affects expression EXP   6480464 Methotrexate affects the expression of TLR4 mRNA CTD PMID:18502557 methotrexate decreases expression ISO RGD:737013 6480464 Methotrexate results in decreased expression of TLR4 mRNA CTD PMID:17400583 morphine affects binding ISO RGD:737013 6480464 Morphine binds to TLR4 protein CTD PMID:20178837 morphine increases expression ISO RGD:3870 6480464 Morphine results in increased expression of TLR4 protein CTD PMID:20178837 morphine affects response to substance ISO RGD:3870 6480464 Morphine affects the susceptibility to TLR4 protein CTD PMID:20178837 morphine multiple interactions ISO RGD:737013 6480464 Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 muramyl dipeptide increases activity ISO RGD:737013 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 protein CTD PMID:15905553 muramyl dipeptide increases response to substance EXP   6480464 TLR4 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog CTD PMID:15905553 muramyl dipeptide increases activity EXP   6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 protein CTD PMID:15905553 N-acetyl-L-cysteine multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; more ... CTD PMID:19627980 N-acetyl-L-cysteine decreases expression ISO RGD:737013 6480464 Acetylcysteine results in decreased expression of TLR4 mRNA CTD PMID:22385246 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:3870 6480464 Methylnitronitrosoguanidine results in increased expression of TLR4 mRNA CTD PMID:15120970 naloxone multiple interactions ISO RGD:737013 6480464 Naloxone affects the reaction [Methadone binds to TLR4 protein]; more ... CTD PMID:20178837 naproxen multiple interactions ISO RGD:3870 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; more ... CTD PMID:22150557 nitric oxide multiple interactions EXP   6480464 TLR4 gene mutant form inhibits the reaction [Fungal Polysaccharides results in increased abundance of Nitric Oxide] CTD PMID:22687552 oxaliplatin decreases response to substance EXP   6480464 TLR4 protein results in decreased susceptibility to oxaliplatin CTD PMID:18789402 ozone multiple interactions EXP   6480464 [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR4 mRNA CTD PMID:16864405 ozone increases expression EXP   6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:11159012 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:17626835 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:21543283 more ... ozone increases response to substance EXP   6480464 TLR4 results in increased susceptibility to Ozone CTD PMID:21543283 ozone increases expression EXP   6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:21543283 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:17626835 more ... ozone increases response to substance EXP   6480464 TLR4 protein results in increased susceptibility to Ozone CTD PMID:11159012 ozone decreases response to substance EXP   6480464 TLR4 protein mutant form results in decreased susceptibility to Ozone CTD PMID:11159012 ozone multiple interactions EXP   6480464 TLR4 protein affects the reaction [Ozone results in increased expression of NOS2 mRNA] CTD PMID:11159012 ozone decreases response to substance EXP   6480464 TLR4 gene mutant form results in decreased susceptibility to Ozone CTD PMID:17626835 ozone multiple interactions EXP   6480464 TLR4 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; more ... CTD PMID:17626835 ozone increases expression EXP   6480464 Ozone results in increased expression of TLR4 mRNA CTD PMID:11159012 more ... ozone decreases expression EXP   6480464 Ozone results in decreased expression of TLR4 mRNA mutant form CTD PMID:11159012 paclitaxel multiple interactions EXP   6480464 TLR4 protein affects the reaction [Paclitaxel results in increased expression of CXCL10 mRNA]; more ... CTD PMID:11123339 paclitaxel affects response to substance EXP   6480464 TLR4 protein affects the susceptibility to Paclitaxel CTD PMID:11581577 paracetamol affects expression EXP   6480464 Acetaminophen affects the expression of TLR4 mRNA CTD PMID:17562736 paracetamol increases response to substance EXP   6480464 TLR4 results in increased susceptibility to Acetaminophen CTD PMID:16439473 paracetamol multiple interactions EXP   6480464 [Ethanol co-treated with isopentyl alcohol] promotes the reaction [TLR4 results in increased susceptibility to Acetaminophen] CTD PMID:16439473 pirinixic acid decreases expression EXP   6480464 pirinixic acid results in decreased expression of TLR4 mRNA CTD PMID:16985257 polymyxin B2 multiple interactions ISO RGD:737013 6480464 Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:3870 6480464 Pregnenolone Carbonitrile results in decreased expression of TLR4 mRNA CTD PMID:19162173 progesterone multiple interactions ISO RGD:737013 6480464 Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 progesterone increases expression ISO RGD:737013 6480464 Progesterone results in increased expression of TLR4 mRNA; more ... CTD PMID:17701593 propofol multiple interactions EXP   6480464 Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; more ... CTD PMID:19433076 quercetin increases expression ISO RGD:737013 6480464 Quercetin results in increased expression of TLR4 mRNA CTD PMID:21632981 resveratrol decreases expression ISO RGD:737013 6480464 resveratrol results in decreased expression of TLR4 CTD PMID:22251620 resveratrol decreases expression ISO RGD:3870 6480464 resveratrol results in decreased expression of TLR4 mRNA; more ... CTD PMID:22246136 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of AKT1 protein]; more ... CTD PMID:22118570 rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction [AGT protein results in increased expression of TLR4 mRNA]; more ... CTD PMID:19778788 rosiglitazone multiple interactions ISO RGD:3870 6480464 TLR4 protein affects the reaction [rosiglitazone inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of TNF protein]] CTD PMID:19451898 silicon dioxide decreases expression EXP   6480464 Silicon Dioxide results in decreased expression of TLR4 mRNA CTD PMID:19073995 simvastatin increases expression ISO RGD:737013 6480464 Simvastatin results in increased expression of TLR4 protein CTD PMID:16387846 simvastatin multiple interactions ISO RGD:737013 6480464 Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:16443229 simvastatin decreases expression ISO RGD:3870 6480464 Simvastatin results in decreased expression of TLR4 mRNA; more ... CTD PMID:19166837 streptozocin multiple interactions ISO RGD:737013 6480464 TNF protein inhibits the reaction [Streptozocin results in increased expression of TLR4 mRNA] CTD PMID:20446767 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of TLR4 mRNA CTD PMID:20446767 succimer multiple interactions EXP   6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TLR4 mRNA CTD PMID:21641980 sumatriptan multiple interactions ISO RGD:3870 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; more ... CTD PMID:22150557 telmisartan multiple interactions ISO RGD:737013 6480464 [atorvastatin co-treated with telmisartan] results in decreased expression of TLR4 mRNA; more ... CTD PMID:20524934 tetrachloromethane increases expression ISO RGD:3870 6480464 Carbon Tetrachloride results in increased expression of TLR4 mRNA; more ... CTD PMID:17504260 tetrachloromethane multiple interactions ISO RGD:3870 6480464 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; more ... CTD PMID:23146752 tetrachloromethane increases expression ISO RGD:3870 6480464 Carbon Tetrachloride results in increased expression of TLR4 mRNA; more ... CTD PMID:17504260 more ... tetrachloromethane multiple interactions ISO RGD:3870 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; more ... CTD PMID:22683883 tetrachloromethane increases expression ISO RGD:3870 6480464 Carbon Tetrachloride results in increased expression of TLR4 mRNA; more ... CTD PMID:17504260 PMID:22683883 tetrachloromethane multiple interactions EXP   6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; more ... CTD PMID:21291945 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of TLR4 mRNA; more ... CTD PMID:21291945 tetrachloromethane multiple interactions ISO RGD:3870 6480464 Lipopolysaccharides promotes the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein] CTD PMID:17504260 tetrachloromethane affects expression EXP   6480464 Carbon Tetrachloride affects the expression of TLR4 mRNA CTD PMID:17484886 titanium atom multiple interactions ISO RGD:3870 6480464 [Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR4 mRNA CTD PMID:21308757 titanium atom increases expression EXP   6480464 Titanium results in increased expression of TLR4 mRNA CTD PMID:20682337 trans-resveratrol decreases expression ISO RGD:737013 6480464 resveratrol results in decreased expression of TLR4 CTD PMID:22251620 trans-resveratrol decreases expression ISO RGD:3870 6480464 resveratrol results in decreased expression of TLR4 mRNA; more ... CTD PMID:22246136 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of AKT1 protein]; more ... CTD PMID:22118570 zinc atom increases expression ISO RGD:3870 6480464 Zinc deficiency results in increased expression of TLR4 mRNA CTD PMID:19111725 zinc atom increases expression ISO RGD:3870 6480464 Zinc deficiency results in increased expression of TLR4 mRNA CTD PMID:19111725 PMID:22689922 zinc(0) increases expression ISO RGD:3870 6480464 Zinc deficiency results in increased expression of TLR4 mRNA CTD PMID:19111725 zinc(0) increases expression ISO RGD:3870 6480464 Zinc deficiency results in increased expression of TLR4 mRNA CTD PMID:19111725 PMID:22689922 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of innate immune response   IMP MGI:MGI:1860885 2290270 MGI:MGI:3530402|PMID:15661922 MGI MGI:MGI:3530402 PMID:15661922 activation of MAPK activity   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 activation of NF-kappaB-inducing kinase activity   NAS   2290270 MGI:MGI:3688055|PMID:11490012 UniProtKB MGI:MGI:3688055 PMID:11490012 B cell proliferation involved in immune response   IMP   2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 cellular response to lipopolysaccharide   IMP   2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 cellular response to lipopolysaccharide   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 cellular response to lipopolysaccharide   IDA   2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 cellular response to lipoteichoic acid   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 defense response to bacterium   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 defense response to Gram-negative bacterium   IMP MGI:MGI:1860885 2290270 MGI:MGI:3530402|PMID:15661922 MGI MGI:MGI:3530402 PMID:15661922 detection of lipopolysaccharide   TAS   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 detection of lipopolysaccharide   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 I-kappaB phosphorylation   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 immune response   IEA InterPro:IPR017241 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 inflammatory response   IEA UniProtKB-KW:KW-0395 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 innate immune response   TAS   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 innate immune response-activating signal transduction   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 interferon-gamma production   IGI MGI:MGI:1270861 2290270 MGI:MGI:2148358|PMID:11489994 MGI MGI:MGI:2148358 PMID:11489994 intestinal epithelial structure maintenance   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 leukotriene metabolic process   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 lipopolysaccharide-mediated signaling pathway   IDA   2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 lipopolysaccharide-mediated signaling pathway NOT ISO UniProtKB:O00206 2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 lipopolysaccharide-mediated signaling pathway   IGI MGI:MGI:1341909 2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 lipopolysaccharide-mediated signaling pathway   ISO UniProtKB:O00206 2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 lipopolysaccharide-mediated signaling pathway   IGI MGI:MGI:1321404|MGI:MGI:1194924 2290270 MGI:MGI:1860539|PMID:10880523 MGI MGI:MGI:1860539 PMID:10880523 macrophage activation   ISS UniProtKB:O00206 2290270 MGI:MGI:3687811|PMID:10835634 UniProtKB MGI:MGI:3687811 PMID:10835634 macrophage activation   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 mast cell activation   NAS   2290270 MGI:MGI:3688028|PMID:11739561 UniProtKB MGI:MGI:3688028 PMID:11739561 mast cell activation   NAS   2290270 MGI:MGI:3688055|PMID:11490012 UniProtKB MGI:MGI:3688055 PMID:11490012 microglial cell activation involved in immune response   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of ERK1 and ERK2 cascade   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 negative regulation of interferon-gamma production   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 negative regulation of interleukin-17 production   IMP   2290270 MGI:MGI:3773594|PMID:18203139 BHF-UCL MGI:MGI:3773594 PMID:18203139 negative regulation of interleukin-17 production   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 negative regulation of interleukin-23 production   IMP   2290270 MGI:MGI:3773594|PMID:18203139 BHF-UCL MGI:MGI:3773594 PMID:18203139 negative regulation of interleukin-6 production   IMP   2290270 MGI:MGI:3773594|PMID:18203139 BHF-UCL MGI:MGI:3773594 PMID:18203139 negative regulation of interleukin-6 production   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 negative regulation of tumor necrosis factor production   IMP   2290270 MGI:MGI:4421230|PMID:20051628 BHF-UCL MGI:MGI:4421230 PMID:20051628 nitric oxide production involved in inflammatory response   IMP MGI:MGI:1857718 2290270 MGI:MGI:1351361|PMID:10623794 MGI MGI:MGI:1351361 PMID:10623794 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of apoptotic process   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of B cell proliferation   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of chemokine production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of chemokine production   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of DNA binding   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of ERK1 and ERK2 cascade   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of I-kappaB kinase/NF-kappaB cascade   IDA   2290270 MGI:MGI:3607973|PMID:16260493 MGI MGI:MGI:3607973 PMID:16260493 positive regulation of I-kappaB kinase/NF-kappaB cascade   IDA   2290270 MGI:MGI:4359971|PMID:19734906 MGI MGI:MGI:4359971 PMID:19734906 positive regulation of I-kappaB kinase/NF-kappaB cascade   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of inflammatory response   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of interferon-alpha production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interferon-beta biosynthetic process   IMP MGI:MGI:1860885 2290270 MGI:MGI:3530402|PMID:15661922 MGI MGI:MGI:3530402 PMID:15661922 positive regulation of interferon-beta production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interferon-gamma production   IMP   2290270 MGI:MGI:3773594|PMID:18203139 BHF-UCL MGI:MGI:3773594 PMID:18203139 positive regulation of interleukin-1 biosynthetic process   NAS   2290270 MGI:MGI:3688055|PMID:11490012 UniProtKB MGI:MGI:3688055 PMID:11490012 positive regulation of interleukin-1 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-10 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-12 biosynthetic process   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of interleukin-12 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-13 biosynthetic process   NAS   2290270 MGI:MGI:3688055|PMID:11490012 UniProtKB MGI:MGI:3688055 PMID:11490012 positive regulation of interleukin-6 biosynthetic process   NAS   2290270 MGI:MGI:3688055|PMID:11490012 UniProtKB MGI:MGI:3688055 PMID:11490012 positive regulation of interleukin-6 production   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of interleukin-6 production   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of interleukin-6 production   NAS   2290270 MGI:MGI:4942252|PMID:12421970 BHF-UCL MGI:MGI:4942252 PMID:12421970 positive regulation of interleukin-6 production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of interleukin-6 production   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of interleukin-8 biosynthetic process   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of interleukin-8 production   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of JNK cascade   IDA   2290270 MGI:MGI:3607973|PMID:16260493 MGI MGI:MGI:3607973 PMID:16260493 positive regulation of JNK cascade   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of JNK cascade   IGI MGI:MGI:1346877 2290270 MGI:MGI:3607973|PMID:16260493 MGI MGI:MGI:3607973 PMID:16260493 positive regulation of lymphocyte proliferation   IMP MGI:MGI:1860885 2290270 MGI:MGI:3640248|PMID:10607756 MGI MGI:MGI:3640248 PMID:10607756 positive regulation of macrophage cytokine production   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of MHC class II biosynthetic process   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of NF-kappaB import into nucleus   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of NF-kappaB transcription factor activity   ISO UniProtKB:O00206 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 positive regulation of NF-kappaB transcription factor activity   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of nitric oxide biosynthetic process   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of nitric-oxide synthase biosynthetic process   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of peptidyl-tyrosine phosphorylation   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of platelet activation   IMP   2290270 MGI:MGI:3838274|PMID:16514062 BHF-UCL MGI:MGI:3838274 PMID:16514062 positive regulation of sequence-specific DNA binding transcription factor activity   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of stress-activated MAPK cascade   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of tumor necrosis factor biosynthetic process   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of tumor necrosis factor production   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 positive regulation of tumor necrosis factor production   IDA   2290270 MGI:MGI:4456948|PMID:15356140 BHF-UCL MGI:MGI:4456948 PMID:15356140 positive regulation of tumor necrosis factor production   IDA   2290270 MGI:MGI:3775161|PMID:18261938 MGI MGI:MGI:3775161 PMID:18261938 positive regulation of tumor necrosis factor production   IMP MGI:MGI:1857718 2290270 MGI:MGI:1351361|PMID:10623794 MGI MGI:MGI:1351361 PMID:10623794 positive regulation of tumor necrosis factor production   IMP MGI:MGI:1860885 2290270 MGI:MGI:3640248|PMID:10607756 MGI MGI:MGI:3640248 PMID:10607756 regulation of inflammatory response   IMP   2290270 MGI:MGI:3773594|PMID:18203139 BHF-UCL MGI:MGI:3773594 PMID:18203139 regulation of sensory perception of pain   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to bacterium   IMP   2290270 MGI:MGI:3608578|PMID:11294571 MGI MGI:MGI:3608578 PMID:11294571 response to ethanol   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to fatty acid   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to lipopolysaccharide   IGI MGI:MGI:1270861 2290270 MGI:MGI:2148358|PMID:11489994 MGI MGI:MGI:2148358 PMID:11489994 response to lipopolysaccharide   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to lipopolysaccharide   ISO UniProtKB:O00206 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 response to lipopolysaccharide   IMP MGI:MGI:1860885 2290270 MGI:MGI:2178646|PMID:10549626 MGI MGI:MGI:2178646 PMID:10549626 response to lipopolysaccharide   IMP MGI:MGI:1860885 2290270 MGI:MGI:3640248|PMID:10607756 MGI MGI:MGI:3640248 PMID:10607756 response to lipopolysaccharide   IMP MGI:MGI:1857718 2290270 MGI:MGI:3719540|PMID:12055258 MGI MGI:MGI:3719540 PMID:12055258 response to lipopolysaccharide   IMP MGI:MGI:1857718|MGI:MGI:1860755 2290270 MGI:MGI:1336850|PMID:10229796 MGI MGI:MGI:1336850 PMID:10229796 response to oxidative stress   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 signal transduction   IEA InterPro:IPR000157 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 toll-like receptor signaling pathway   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell surface   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytoplasm   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cytoplasm   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 external side of plasma membrane   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 integral to membrane   IEA InterPro:IPR017241 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 integral to membrane   IEA UniProtKB-KW:KW-0812 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 integral to plasma membrane   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 lipopolysaccharide receptor complex   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 membrane   IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 membrane raft colocalizes_with ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 perinuclear region of cytoplasm   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 plasma membrane   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) lipopolysaccharide binding   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 lipopolysaccharide binding   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 lipopolysaccharide receptor activity   ISO UniProtKB:O00206 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 phosphatidylinositol 3-kinase binding   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein binding   IPI UniProtKB:Q9JHF9 2290270 MGI:MGI:3763315|PMID:17803912 IntAct MGI:MGI:3763315 PMID:17803912 receptor activity   ISO UniProtKB:Q9QX05 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transmembrane signaling receptor activity   IEA InterPro:IPR017241 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Entamoeba histolyca infection pathway   IEA RGD:737014 6907045   KEGG mmu:05146 influenza A virus infection pathway   IEA RGD:737014 6907045   KEGG mmu:05164 Leishmania infection pathway   IEA RGD:737014 6907045   KEGG mmu:05140 measles infection pathway   IEA RGD:737014 6907045   KEGG mmu:05162 Mycobacterium tuberculosis infection pathway   IEA RGD:737014 6907045   KEGG mmu:05152 Plasmodium infection pathway   IEA RGD:737014 6907045   KEGG mmu:05144 rheumatoid arthritis pathway   IEA RGD:737014 6907045   KEGG mmu:05323 Toll-like receptor signaling pathway   ISS RGD:3870 1643119   RGD   Toll-like receptor signaling pathway   IEA RGD:737014 6907045   KEGG mmu:04620 Toll-like receptor signaling pathway   ISS RGD:737013 5685014   RGD   Toxoplasma gondii infection pathway   IEA RGD:737014 6907045   KEGG mmu:05145 Trypanosoma cruzi infection pathway   IEA RGD:737014 6907045   KEGG mmu:05142 External Database Links KEGG Pathway Amoebiasis Chagas disease (American trypanosomiasis) Hepatitis B HIF-1 signaling pathway Influenza A Legionellosis Leishmaniasis Malaria Measles NF-kappa B signaling pathway Pertussis Phagosome PI3K-Akt signaling pathway Proteoglycans in cancer Rheumatoid arthritis Salmonella infection Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Pathway Interaction Database Endogenous TLR signaling (PID:200208) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal acute inflammation   IAGP   5509061   MGI PMID:15826931 abnormal airway responsiveness   IAGP   5509061   MGI PMID:17626835 abnormal artery morphology   IAGP   5509061   MGI PMID:14699006 abnormal bone structure   IAGP   5509061   MGI PMID:15208271 abnormal chemokine secretion   IAGP   5509061   MGI PMID:16244651 abnormal circulating enzyme level   IAGP   5509061   MGI PMID:15996225 abnormal circulating glucose level   IAGP   5509061   MGI PMID:17519423 abnormal circulating leptin level   IAGP   5509061   MGI PMID:17519423 abnormal cytokine level   IAGP   5509061   MGI PMID:15731076 abnormal cytokine secretion   IAGP   5509061   MGI PMID:15039311 abnormal cytokine secretion   IAGP   5509061   MGI PMID:17118979 abnormal cytokine secretion   IAGP   5509061   MGI PMID:17314284 abnormal dendritic cell physiology   IAGP   5509061   MGI PMID:15039466 abnormal enterocyte proliferation   IAGP   5509061   MGI PMID:19786028 abnormal fatty acid level   IAGP   5509061   MGI PMID:17519423 abnormal fibroblast proliferation   IAGP   5509061   MGI PMID:19786028 abnormal gas homeostasis   IAGP   5509061   MGI PMID:17519423 abnormal glial cell apoptosis   IAGP   5509061   MGI PMID:15879150 abnormal glial cell physiology   IAGP   5509061   MGI PMID:15809417 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:17519423 abnormal granulocyte physiology   IAGP   5509061   MGI PMID:15039466 abnormal hepatocyte morphology   IAGP   5509061   MGI PMID:16118350 abnormal immune cell physiology   IAGP   5509061   MGI PMID:15039466 abnormal inflammatory response   IAGP   5509061   MGI PMID:16322526 abnormal interleukin level   IAGP   5509061   MGI PMID:15731076 abnormal level of surface class II molecules   IAGP   5509061   MGI PMID:10549626 abnormal lipid level   IAGP   5509061   MGI PMID:17519423 abnormal liver physiology   IAGP   5509061   MGI PMID:15795240 abnormal locomotor behavior   IAGP   5509061   MGI PMID:17403033 abnormal lung interstitium morphology   IAGP   5509061   MGI PMID:16244651 abnormal macrophage chemotaxis   IAGP   5509061   MGI PMID:17403033 abnormal macrophage physiology   IAGP   5509061   MGI PMID:10549626 abnormal macrophage physiology   IAGP   5509061   MGI PMID:16148141 abnormal macrophage physiology   IAGP   5509061   MGI PMID:17118979 abnormal macrophage physiology   IAGP   5509061   MGI PMID:17353199 abnormal macrophage physiology   IAGP   5509061   MGI PMID:15039311 abnormal macrophage physiology   IAGP   5509061   MGI PMID:15039466 abnormal microglial cell physiology   IAGP   5509061   MGI PMID:15879150 abnormal motor coordination/ balance   IAGP   5509061   MGI PMID:17403033 abnormal muscle cell glucose uptake   IAGP   5509061   MGI PMID:17519423 abnormal myelin sheath morphology   IAGP   5509061   MGI PMID:17403033 abnormal nephron morphology   IAGP   5509061   MGI PMID:18974879 abnormal nervous system morphology   IAGP   5509061   MGI PMID:17693552 abnormal neuron differentiation   IAGP   5509061   MGI PMID:17704767 abnormal NK cell physiology   IAGP   5509061   MGI PMID:15039466 abnormal osteoclast differentiation   IAGP   5509061   MGI PMID:18209032 abnormal phagocyte morphology   IAGP   5509061   MGI PMID:17767165 abnormal proximal convoluted tubule brush border morphology   IAGP   5509061   MGI PMID:18974879 abnormal pulmonary alveolar duct morphology   IAGP   5509061   MGI PMID:17053835 abnormal pulmonary alveolus morphology   IAGP   5509061   MGI PMID:17053835 abnormal pulmonary elastic fiber morphology   IAGP   5509061   MGI PMID:17053835 abnormal renal tubule epithelium morphology   IAGP   5509061   MGI PMID:18974879 abnormal renal tubule morphology   IAGP   5509061   MGI PMID:18974879 abnormal respiratory system morphology   IAGP   5509061   MGI PMID:17053835 abnormal respiratory system physiology   IAGP   5509061   MGI PMID:15731076 abnormal respiratory system physiology   IAGP   5509061   MGI PMID:17626835 abnormal retinal layer morphology   IAGP   5509061   MGI PMID:18981228 abnormal retinal pigment epithelium morphology   IAGP   5509061   MGI PMID:18981228 abnormal retinal progenitor cell morphology   IAGP   5509061   MGI PMID:18981228 abnormal retinal rod bipolar cell morphology   IAGP   5509061   MGI PMID:18981228 abnormal retinal rod cell morphology   IAGP   5509061   MGI PMID:18981228 abnormal spleen weight   IAGP   5509061   MGI PMID:8982246 abnormal T-helper 2 physiology   IAGP   5509061   MGI PMID:15684036 abnormal tumor necrosis factor level   IAGP   5509061   MGI PMID:15996225 abnormal tumor necrosis factor level   IAGP   5509061   MGI PMID:15731076 abnormal tumor necrosis factor level   IAGP   5509061   MGI PMID:17707128 abnormal vascular wound healing   IAGP   5509061   MGI PMID:14699006 altered susceptibility to atherosclerosis   IAGP   5509061   MGI PMID:15249654 altered susceptibility to infection   IAGP   5509061   MGI PMID:18802464 atherosclerotic lesions   IAGP   5509061   MGI PMID:14699006 CNS ischemia   IAGP   5509061   MGI PMID:19401158 colitis   IAGP   5509061   MGI PMID:12727921 decreased acute inflammation   IAGP   5509061   MGI PMID:8982246 decreased angiogenesis   IAGP   5509061   MGI PMID:20708624 decreased B cell number   IAGP   5509061   MGI PMID:16703567 decreased B cell proliferation   IAGP   5509061   MGI PMID:10549626 decreased body size   IAGP   5509061   MGI PMID:15208271 decreased body temperature   IAGP   5509061   MGI PMID:18802464 decreased body weight   IAGP   5509061   MGI PMID:17519423 decreased cerebral infarction size   IAGP   5509061   MGI PMID:17188246 decreased cerebral infarction size   IAGP   5509061   MGI PMID:17693552 decreased circulating alanine transaminase level   IAGP   5509061   MGI PMID:15996225 decreased circulating insulin level   IAGP   5509061   MGI PMID:17519423 decreased circulating interleukin-6 level   IAGP   5509061   MGI PMID:18423196 decreased epididymal fat pad weight   IAGP   5509061   MGI PMID:17519423 decreased eye pigmentation   IEA   5509061   MGI   decreased fat cell size   IAGP   5509061   MGI PMID:17519423 decreased hemoglobin content   IAGP   5509061   MGI PMID:15826931 decreased hepatocyte apoptosis   IAGP   5509061   MGI PMID:16118350 decreased IgG3 level   IAGP   5509061   MGI PMID:17118979 decreased incidence of chemically-induced tumors   IAGP   5509061   MGI PMID:20526283 decreased incidence of chemically-induced tumors   IAGP   5509061   MGI PMID:18054559 decreased interferon-gamma secretion   IAGP   5509061   MGI PMID:11489994 decreased interferon-gamma secretion   IAGP   5509061   MGI PMID:12727921 decreased interferon-gamma secretion   IAGP   5509061   MGI PMID:15039466 decreased interleukin-1 beta secretion   IEA   5509061   MGI   decreased interleukin-10 secretion   IAGP   5509061   MGI PMID:17525287 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:10549626 decreased interleukin-6 secretion   IAGP   5509061   MGI PMID:17525287 decreased liver triglyceride level   IAGP   5509061   MGI PMID:17519423 decreased neuron apoptosis   IAGP   5509061   MGI PMID:17693552 decreased percent body fat   IAGP   5509061   MGI PMID:15208271 decreased respiratory quotient   IAGP   5509061   MGI PMID:17519423 decreased response of heart to induced stress   IAGP   5509061   MGI PMID:15967420 decreased sensitivity to induced morbidity/mortality   IAGP   5509061   MGI PMID:17353199 decreased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:11294571 decreased susceptibility to bone fracture   IAGP   5509061   MGI PMID:15208271 decreased susceptibility to endotoxin shock   IAGP   5509061   MGI PMID:19786028 decreased susceptibility to endotoxin shock   IAGP   5509061   MGI PMID:12727921 decreased susceptibility to endotoxin shock   IAGP   5509061   MGI PMID:10549626 decreased susceptibility to induced arthritis   IAGP   5509061   MGI PMID:19218085 decreased susceptibility to injury   IAGP   5509061   MGI PMID:15809417 decreased susceptibility to injury   IAGP   5509061   MGI PMID:18423196 decreased susceptibility to ischemic brain injury   IAGP   5509061   MGI PMID:17188246 decreased susceptibility to kidney reperfusion injury   IAGP   5509061   MGI PMID:18974879 decreased susceptibility to viral infection   IAGP   5509061   MGI PMID:18423196 decreased susceptibility to weight loss   IAGP   5509061   MGI PMID:18802464 decreased tail pigmentation   IEA   5509061   MGI   decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:10549626 decreased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:16148141 dilated pulmonary alveolar ducts   IAGP   5509061   MGI PMID:17053835 dilated renal tubules   IAGP   5509061   MGI PMID:18974879 diluted coat color   IEA   5509061   MGI   enlarged lung   IAGP   5509061   MGI PMID:17053835 enlarged lymph nodes   IAGP   5509061   MGI PMID:15826931 focal hepatic necrosis   IAGP   5509061   MGI PMID:16118350 hyperoxia   IAGP   5509061   MGI PMID:16244651 hyporesponsive to tactile stimuli   IAGP   5509061   MGI PMID:15809417 impaired neutrophil chemotaxis   IAGP   5509061   MGI PMID:15826931 improved glucose tolerance   IAGP   5509061   MGI PMID:17519423 increased adiponectin level   IAGP   5509061   MGI PMID:17519423 increased apoptosis   IAGP   5509061   MGI PMID:16244651 increased B-1 B cell number   IAGP   5509061   MGI PMID:16703567 increased bone mass   IAGP   5509061   MGI PMID:15208271 increased bone mineral content   IAGP   5509061   MGI PMID:15208271 increased bone mineral density   IAGP   5509061   MGI PMID:15208271 increased circulating interleukin-6 level   IAGP   5509061   MGI PMID:8982246 increased interleukin-4 secretion   IAGP   5509061   MGI PMID:15039466 increased lung compliance   IAGP   5509061   MGI PMID:17053835 increased oxygen consumption   IAGP   5509061   MGI PMID:17519423 increased physiological sensitivity to xenobiotic   IAGP   5509061   MGI PMID:16244651 increased spleen weight   IAGP   5509061   MGI PMID:8982246 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:16891416 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:15826931 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:10201887 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:15039311 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:9851930 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:14742522 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:1086804 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:15039466 increased susceptibility to bacterial infection   IAGP   5509061   MGI PMID:11489994 increased susceptibility to induced arthritis   IAGP   5509061   MGI PMID:15684036 increased susceptibility to viral infection induced morbidity/mortality   IAGP   5509061   MGI PMID:18802464 increased thermal nociceptive threshold   IAGP   5509061   MGI PMID:15809417 liver inflammation   IAGP   5509061   MGI PMID:16118350 lung inflammation   IAGP   5509061   MGI PMID:15731076 pulmonary edema   IAGP   5509061   MGI PMID:15731076 rectal hemorrhage   IAGP   5509061   MGI PMID:8982246 renal cast   IAGP   5509061   MGI PMID:18974879 renal tubular necrosis   IAGP   5509061   MGI PMID:18974879 Disease Annotations Acute Kidney Injury  (IEP,IPM,ISS) Acute Lung Injury  (ISS) Acute Tubulointerstitial Nephritis  (IPM) Alzheimer Disease  (ISS) Amoebiasis due to Entamoeba histolytica  (IPM) Arteriosclerosis  (ISS) Asthma  (IED,IPM,ISS) Bacteremia  (ISS) Brain Injuries  (ISS) Brain Ischemia  (ISS) Bronchial Hyperreactivity  (IPM) Bronchiolitis, Viral  (ISS) Carotid Artery Diseases  (ISS) Carotid Stenosis  (ISS) Colitis  (ISS) Colorectal Neoplasms  (ISS) Coronary Artery Disease  (ISS) Cystic Fibrosis  (IPM,ISS) Diabetes Mellitus  (ISS) Diabetes Mellitus, Experimental  (ISS) Diabetes Mellitus, Type 1  (IEP,ISS) Diabetes Mellitus, Type 2  (IEP,ISS) Diabetic Nephropathies  (IPM) Diabetic Neuropathies  (ISS) Diabetic Retinopathy  (ISS) Encephalomyelitis, Autoimmune, Experimental  (ISS) Endotoxemia  (ISS) Enterocolitis, Necrotizing  (ISS) Eye Infections, Fungal  (ISS) Glomerulonephritis  (IED,IPM) Hepatorenal Syndrome  (ISS) Hyperalgesia  (ISS) Hypertension, Pulmonary  (IPM) Ileitis  (IPM) Insulin Resistance  (IAGP,ISS) Kidney Failure, Chronic  (ISS) Kidney Reperfusion Injury  (IEP,IPM,ISS) Leptospirosis  (IPM) Liver Cirrhosis, Experimental  (ISS) Liver Failure, Acute  (ISS) Lung Diseases  (IEP,IPM,ISS) Lupus Erythematosus, Systemic  (IPM) Macular Degeneration  (ISS) Macular Degeneration, Age-Related, 10  (ISS) Multiple Sclerosis  (ISS) Myocardial Infarction  (ISS) Myocardial Reperfusion Injury  (ISS) Neuralgia  (ISS) Neuritis, Autoimmune, Experimental  (ISS) Obesity  (IAGP,ISS) Pain  (ISS) Pancreatitis  (IPM,ISS) Pancreatitis, Acute Necrotizing  (ISS) Pneumonia  (IPM) Pneumonia, Bacterial  (IPM) Pre-Eclampsia  (ISS) Pulmonary Disease, Chronic Obstructive  (ISS) Pulmonary Edema  (IPM) Pulmonary Emphysema  (IPM) Pulmonary Fibrosis  (IPM) Renal Fibrosis  (ISS) Renal Insufficiency  (ISS) Reperfusion Injury  (IPM,ISS) Respiratory Hypersensitivity  (ISS) Respiratory Syncytial Virus Infections  (IPM,ISS) Rhinitis, Allergic, Seasonal  (ISS) Sepsis  (ISS) Subarachnoid Hemorrhage  (ISS) Transplant Rejection  (IPM) Tuberculosis  (IPM) Tuberculosis, Pleural  (ISS) Tuberculosis, Pulmonary  (ISS) Urinary Bladder Neoplasms  (IPM) Uveitis  (ISS) Wallerian Degeneration  (IAGP) Gene-Chemical Interaction Annotations 1,4-dithiothreitol  (EXP) 1-chloro-2,4,6-trinitrobenzene  (EXP) 17beta-hydroxy-5alpha-androstan-3-one  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 3,3',4,4',5-pentachlorobiphenyl  (ISO) 4-hydroxynon-2-enal  (EXP,ISO) adenosine  (ISO) aflatoxin B1  (ISO) all-trans-retinoic acid  (ISO) all-trans-retinol  (ISO) aluminium hydroxide  (EXP) ammonium chloride  (ISO) arsenic atom  (ISO) arsenite(3-)  (EXP) auranofin  (EXP) baicalin  (ISO) benazepril  (ISO) benzo[a]pyrene  (EXP) berberine  (EXP) bicalutamide  (ISO) bis(2-chloroethyl) sulfide  (EXP) bisdemethoxycurcumin  (ISO) capsaicin  (ISO) carbamazepine  (EXP) cerium trichloride  (EXP) chitosan  (ISO) chlorogenic acid  (ISO) choline  (EXP) chromium atom  (ISO) cisplatin  (EXP) cortisol  (ISO) curcumin  (EXP,ISO) D-glucose  (EXP,ISO) daunorubicin  (EXP) dexamethasone  (ISO) dextran sulfate  (EXP) diazinon  (EXP) diazoxide  (EXP) dienogest  (ISO) dioxygen  (ISO) doxorubicin  (EXP) enalapril  (ISO) ethanol  (EXP,ISO) eugenol  (ISO) ferulic acid  (EXP) folic acid  (EXP) glucose  (EXP,ISO) glutathione  (ISO) GM1 ganglioside  (ISO) halothane  (EXP) indomethacin  (EXP) isoamylol  (EXP) isoprenaline  (EXP) ketamine  (EXP) L-methionine  (EXP) lycopene  (ISO) magnesium dihydroxide  (EXP) melphalan  (ISO) methadone  (ISO) methotrexate  (EXP,ISO) morphine  (ISO) muramyl dipeptide  (EXP,ISO) N-acetyl-L-cysteine  (EXP,ISO) N-methyl-N'-nitro-N-nitrosoguanidine  (ISO) naloxone  (ISO) naproxen  (ISO) nitric oxide  (EXP) oxaliplatin  (EXP) ozone  (EXP) paclitaxel  (EXP) paracetamol  (EXP) pirinixic acid  (EXP) polymyxin B2  (ISO) pregnenolone 16alpha-carbonitrile  (ISO) progesterone  (ISO) propofol  (EXP) quercetin  (ISO) resveratrol  (EXP,ISO) rosiglitazone  (EXP,ISO) silicon dioxide  (EXP) simvastatin  (ISO) streptozocin  (EXP,ISO) succimer  (EXP) sumatriptan  (ISO) telmisartan  (ISO) tetrachloromethane  (EXP,ISO) titanium atom  (EXP,ISO) trans-resveratrol  (EXP,ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process activation of innate immune response  (IMP) activation of MAPK activity  (IMP) activation of NF-kappaB-inducing kinase activity  (NAS) B cell proliferation involved in immune response  (IMP) cellular response to lipopolysaccharide  (IDA,IMP) cellular response to lipoteichoic acid  (IMP) defense response to bacterium  (ISO) defense response to Gram-negative bacterium  (IMP) detection of lipopolysaccharide  (ISO,TAS) I-kappaB phosphorylation  (ISO) immune response  (IEA) inflammatory response  (IEA) innate immune response  (TAS) innate immune response-activating signal transduction  (ISO) interferon-gamma production  (IGI) intestinal epithelial structure maintenance  (IMP) leukotriene metabolic process  (ISO) lipopolysaccharide-mediated signaling pathway  (IDA,IGI,ISO) macrophage activation  (ISO,ISS) mast cell activation  (NAS) microglial cell activation involved in immune response  (ISO) negative regulation of ERK1 and ERK2 cascade  (IMP) negative regulation of interferon-gamma production  (IMP) negative regulation of interleukin-17 production  (IMP) negative regulation of interleukin-23 production  (IMP) negative regulation of interleukin-6 production  (IMP) negative regulation of tumor necrosis factor production  (IMP) nitric oxide production involved in inflammatory response  (IMP) pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response  (ISO) positive regulation of apoptotic process  (ISO) positive regulation of B cell proliferation  (IMP) positive regulation of chemokine production  (IDA,ISO) positive regulation of DNA binding  (ISO) positive regulation of ERK1 and ERK2 cascade  (IDA) positive regulation of I-kappaB kinase/NF-kappaB cascade  (IDA) positive regulation of inflammatory response  (ISO) positive regulation of interferon-alpha production  (IDA) positive regulation of interferon-beta biosynthetic process  (IMP) positive regulation of interferon-beta production  (IDA) positive regulation of interferon-gamma production  (IMP) positive regulation of interleukin-1 biosynthetic process  (NAS) positive regulation of interleukin-1 production  (IDA) positive regulation of interleukin-10 production  (IDA) positive regulation of interleukin-12 biosynthetic process  (ISO) positive regulation of interleukin-12 production  (IDA) positive regulation of interleukin-13 biosynthetic process  (NAS) positive regulation of interleukin-6 biosynthetic process  (NAS) positive regulation of interleukin-6 production  (IDA,IMP,ISO,NAS) positive regulation of interleukin-8 biosynthetic process  (ISO) positive regulation of interleukin-8 production  (ISO) positive regulation of JNK cascade  (IDA,IGI) positive regulation of lymphocyte proliferation  (IMP) positive regulation of macrophage cytokine production  (IMP) positive regulation of MHC class II biosynthetic process  (IMP) positive regulation of NF-kappaB import into nucleus  (ISO) positive regulation of NF-kappaB transcription factor activity  (ISO) positive regulation of nitric oxide biosynthetic process  (IMP) positive regulation of nitric-oxide synthase biosynthetic process  (IDA) positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA) positive regulation of peptidyl-tyrosine phosphorylation  (ISO) positive regulation of platelet activation  (IMP) positive regulation of sequence-specific DNA binding transcription factor activity  (ISO) positive regulation of stress-activated MAPK cascade  (IDA) positive regulation of transcription from RNA polymerase II promoter  (IDA) positive regulation of tumor necrosis factor biosynthetic process  (ISO) positive regulation of tumor necrosis factor production  (IDA,IMP) regulation of inflammatory response  (IMP) regulation of sensory perception of pain  (ISO) response to bacterium  (IMP) response to ethanol  (ISO) response to fatty acid  (ISO) response to lipopolysaccharide  (IGI,IMP,ISO) response to oxidative stress  (ISO) signal transduction  (IEA) toll-like receptor signaling pathway  (ISO) Cellular Component cell surface  (ISO) cytoplasm  (ISO) external side of plasma membrane  (ISO) integral to membrane  (IEA) integral to plasma membrane  (ISO) lipopolysaccharide receptor complex  (ISO) membrane  (IEA) membrane raft  (ISO) perinuclear region of cytoplasm  (ISO) plasma membrane  (ISO) Molecular Function lipopolysaccharide binding  (ISO) lipopolysaccharide receptor activity  (ISO) phosphatidylinositol 3-kinase binding  (ISO) protein binding  (IPI) receptor activity  (ISO) transmembrane signaling receptor activity  (IEA) Molecular Pathway Annotations Entamoeba histolyca infection pathway  (IEA) influenza A virus infection pathway  (IEA) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) Mycobacterium tuberculosis infection pathway  (IEA) Plasmodium infection pathway  (IEA) rheumatoid arthritis pathway  (IEA) Toll-like receptor signaling pathway  (IEA,ISS) Toxoplasma gondii infection pathway  (IEA) Trypanosoma cruzi infection pathway  (IEA) External Database Links KEGG Pathway Amoebiasis Chagas disease (American trypanosomiasis) Hepatitis B HIF-1 signaling pathway Influenza A Legionellosis Leishmaniasis Malaria Measles NF-kappa B signaling pathway Pertussis Phagosome PI3K-Akt signaling pathway Proteoglycans in cancer Rheumatoid arthritis Salmonella infection Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Pathway Interaction Database Endogenous TLR signaling (PID:200208) Phenotype Annotations abnormal acute inflammation  (IAGP) abnormal airway responsiveness  (IAGP) abnormal artery morphology  (IAGP) abnormal bone structure  (IAGP) abnormal chemokine secretion  (IAGP) abnormal circulating enzyme level  (IAGP) abnormal circulating glucose level  (IAGP) abnormal circulating leptin level  (IAGP) abnormal cytokine level  (IAGP) abnormal cytokine secretion  (IAGP) abnormal dendritic cell physiology  (IAGP) abnormal enterocyte proliferation  (IAGP) abnormal fatty acid level  (IAGP) abnormal fibroblast proliferation  (IAGP) abnormal gas homeostasis  (IAGP) abnormal glial cell apoptosis  (IAGP) abnormal glial cell physiology  (IAGP) abnormal glucose homeostasis  (IAGP) abnormal granulocyte physiology  (IAGP) abnormal hepatocyte morphology  (IAGP) abnormal immune cell physiology  (IAGP) abnormal inflammatory response  (IAGP) abnormal interleukin level  (IAGP) abnormal level of surface class II molecules  (IAGP) abnormal lipid level  (IAGP) abnormal liver physiology  (IAGP) abnormal locomotor behavior  (IAGP) abnormal lung interstitium morphology  (IAGP) abnormal macrophage chemotaxis  (IAGP) abnormal macrophage physiology  (IAGP) abnormal microglial cell physiology  (IAGP) abnormal motor coordination/ balance  (IAGP) abnormal muscle cell glucose uptake  (IAGP) abnormal myelin sheath morphology  (IAGP) abnormal nephron morphology  (IAGP) abnormal nervous system morphology  (IAGP) abnormal neuron differentiation  (IAGP) abnormal NK cell physiology  (IAGP) abnormal osteoclast differentiation  (IAGP) abnormal phagocyte morphology  (IAGP) abnormal proximal convoluted tubule brush border morphology  (IAGP) abnormal pulmonary alveolar duct morphology  (IAGP) abnormal pulmonary alveolus morphology  (IAGP) abnormal pulmonary elastic fiber morphology  (IAGP) abnormal renal tubule epithelium morphology  (IAGP) abnormal renal tubule morphology  (IAGP) abnormal respiratory system morphology  (IAGP) abnormal respiratory system physiology  (IAGP) abnormal retinal layer morphology  (IAGP) abnormal retinal pigment epithelium morphology  (IAGP) abnormal retinal progenitor cell morphology  (IAGP) abnormal retinal rod bipolar cell morphology  (IAGP) abnormal retinal rod cell morphology  (IAGP) abnormal spleen weight  (IAGP) abnormal T-helper 2 physiology  (IAGP) abnormal tumor necrosis factor level  (IAGP) abnormal vascular wound healing  (IAGP) altered susceptibility to atherosclerosis  (IAGP) altered susceptibility to infection  (IAGP) atherosclerotic lesions  (IAGP) CNS ischemia  (IAGP) colitis  (IAGP) decreased acute inflammation  (IAGP) decreased angiogenesis  (IAGP) decreased B cell number  (IAGP) decreased B cell proliferation  (IAGP) decreased body size  (IAGP) decreased body temperature  (IAGP) decreased body weight  (IAGP) decreased cerebral infarction size  (IAGP) decreased circulating alanine transaminase level  (IAGP) decreased circulating insulin level  (IAGP) decreased circulating interleukin-6 level  (IAGP) decreased epididymal fat pad weight  (IAGP) decreased eye pigmentation  (IEA) decreased fat cell size  (IAGP) decreased hemoglobin content  (IAGP) decreased hepatocyte apoptosis  (IAGP) decreased IgG3 level  (IAGP) decreased incidence of chemically-induced tumors  (IAGP) decreased interferon-gamma secretion  (IAGP) decreased interleukin-1 beta secretion  (IEA) decreased interleukin-10 secretion  (IAGP) decreased interleukin-6 secretion  (IAGP) decreased liver triglyceride level  (IAGP) decreased neuron apoptosis  (IAGP) decreased percent body fat  (IAGP) decreased respiratory quotient  (IAGP) decreased response of heart to induced stress  (IAGP) decreased sensitivity to induced morbidity/mortality  (IAGP) decreased susceptibility to bacterial infection  (IAGP) decreased susceptibility to bone fracture  (IAGP) decreased susceptibility to endotoxin shock  (IAGP) decreased susceptibility to induced arthritis  (IAGP) decreased susceptibility to injury  (IAGP) decreased susceptibility to ischemic brain injury  (IAGP) decreased susceptibility to kidney reperfusion injury  (IAGP) decreased susceptibility to viral infection  (IAGP) decreased susceptibility to weight loss  (IAGP) decreased tail pigmentation  (IEA) decreased tumor necrosis factor secretion  (IAGP) dilated pulmonary alveolar ducts  (IAGP) dilated renal tubules  (IAGP) diluted coat color  (IEA) enlarged lung  (IAGP) enlarged lymph nodes  (IAGP) focal hepatic necrosis  (IAGP) hyperoxia  (IAGP) hyporesponsive to tactile stimuli  (IAGP) impaired neutrophil chemotaxis  (IAGP) improved glucose tolerance  (IAGP) increased adiponectin level  (IAGP) increased apoptosis  (IAGP) increased B-1 B cell number  (IAGP) increased bone mass  (IAGP) increased bone mineral content  (IAGP) increased bone mineral density  (IAGP) increased circulating interleukin-6 level  (IAGP) increased interleukin-4 secretion  (IAGP) increased lung compliance  (IAGP) increased oxygen consumption  (IAGP) increased physiological sensitivity to xenobiotic  (IAGP) increased spleen weight  (IAGP) increased susceptibility to bacterial infection  (IAGP) increased susceptibility to induced arthritis  (IAGP) increased susceptibility to viral infection induced morbidity/mortality  (IAGP) increased thermal nociceptive threshold  (IAGP) liver inflammation  (IAGP) lung inflammation  (IAGP) pulmonary edema  (IAGP) rectal hemorrhage  (IAGP) renal cast  (IAGP) renal tubular necrosis  (IAGP) References - curated 1. 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15716415   15718365   15718493   15731053   15731086   15737196   15738005   15755814   15773898   15778388   15778492   15781585   15784548   15784698   15795240   1579857   15809417   15814731   15826931   15845500   15849871   15852007   15864310   15879150   15896296   15902499   15905502   15905547   15905587   15919369   15919371   15920727   15944297   15961512   15964841   15967420   15972657   15972679   15972684   15994412   15996225   16001129   16002681   16002687   16002720   16024722   16025156   16034104   16040976   16041030   16045730   16052598   16081822   16093364   16113279   16113324   16113340   16116197   16116224   16118350   16141072   16141073   16142239   16143103   16148103   16148139   16148141   16154177   16163057   16174756   16177320   16179373   16186163   16210584   16236128   16237097   16237099   16239544   16239556   16239576   16244651   16254214   16260493   16272176   16272281   16272291   16272328   16272344   16283355   16284190   16284241   16291660   16292312   16293680   16299309   16299326   16301658   16301676   16309564   16316333   16322526   16323245   16325814   16333033   16338228   16339563   16344599   16369019   16391018   16393954   16394008   16403908   16413386   16413499   16413927   16424940   16425356   16439473   16455798   16455994   16456012   16456013   16460678   16461338   16461458   16467877   16469054   16473828   16481293   16481302   16489357   16493066   16493068   16500244   16506285   16507888   16514062   16517740   16518342   16523497   16537813   16547261   16547265   16574244   16585574   16602821   16603631   16606831   16609927   16611887   16622187   16622195   16622218   16628628   16648192   16651610   16670292   16670307   16670325   16670331   16675600   16675630   16688168   16703567   16706798   16709832   16709864   16709871   16714560   16717116   16733795   16738669   16751103   16754684   16757566   16766576   16781673   16782847   16785556   16790781   16809643   16814255   16818783   16820585   16829963   16831874   16836770   16847070   16849485   16849487   16861639   16863919   16877769   16879256   16886064   16888154   16891416   16895974   16912041   16916914   16920916   16920968   16926427   16936244   16943680   16946018   16951362   16954198   16954393   16963319   16980981   16982918   16983331   16984919   17000122   17000866   17004992   17010424   17026481   17034585   17034761   17034774   17035347   17038589   17049055   17056563   17060475   17062605   17065506   17071719   17074859   17082484   17082602   17114424   17114485   17114491   17117477   17118979   17123997   17135446   17142724   17151286   17154261   17158890   17163447   17164294   17167049   17170125   17173973   17178921   17182102   17187407   17188246   17196865   17202335   17202370   17202381   17210129   17213198   17218615   17233566   17237423   17237433   17239439   17255318   17267571   17275357   17277152   17277163   17292937   17296755   17312163   17312170   17314284   17322564   17329566   17335558   17339355   17339471   17339472   17339488   17353199   17353291   17360653   17362743   17371986   17372179   17389381   17395901   17400552   17403033   17404301   17412915   17417641   17420011   17433728   17445776   17450126   17456769   17460147   17461416   17474083   17475844   17475888   17478729   17484770   17488888   17490432   17493681   17496895   17507094   17513714   17513715   17513782   17519423   17521621   17525287   1752882   17535806   17536017   17538624   17548522   17548587   17560196   17572686   17573354   17579019   17579042   17579078   17589347   17591966   17599410   17601656   17608742   17617606   17617634   17618294   17623651   17626835   17629795   17632100   17634395   17637846   17641036   17644211   17652449   17653282   17657310   17658277   17664287   17666571   17675512   17676990   17683945   17686871   17690330   17693552   17698322   17701033   17704733   17704767   17704786   17705137   17707128   17709538   17710226   17711480   17711991   17713535   17717323   17767165   17785432   17785837   17785839   17785841   17785847   17803912   17804687   17825254   17851949   17853945   17875630   17878340   17878380   17884182   17888930   17905855   17909078   17916553   17918201   17920684   17921137   17925504   17942529   17947654   17947685   17947709   17950005   17950615   17952090   17954722   17956355   17974996   17980154   17982277   17984303   17992263   17996232   17998311   17998391   18003947   18005362   18006062   18007026   18008007   18042040   18049113   18054398   18054559   18056397   18060042   18061674   18070744   18083111   18085664   18097414   1815711   18165267   18172227   18178848   18178857   18179383   18180038   18180310   18192029   18192488   18199559   18203139   18203953   18205075   18209032   18222170   18227157   18250425   18252714   18252871   18256040   18256356   18261938   18266299   18287332   18287559   18287966   18292574   18295350   18297073   18298550   18299127   18299340   18300366   18309167   18321777   18322079   18322222   18322244   18323674   18332137   18334542   18336909   18339426   18347044   18347194   18354186   18354210   18362039   18372043   18376402   18378686   18391010   18394314   18398934   18399852   18408583   18421279   18422969   18423196   18424698   18436016   18442564   18442801   18445119   18453617   18458086   18480050   18480244   18485892   18486483   18490457   18490467   18490734   18492657   18495130   18495803   18496236   18499758   18509511   18510752   18516037   18516712   18522803   18523261   18523439   18540963   18542102   18559343   18559345   18559428   18562480   18565585   18566425   18566426   18586243   18606678   18615568   18620001   18622013   18624726   18634318   18641311   18641322   18641349   18644971   18650420   18665044   18684936   18684984   18686098   18700834   18701460   18708593   18715916   18718996   18719121   18725520   18725521   18753256   18779779   18782768   18792393   18799752   18802464   18804339   18805964   18818394   18819072   18820644   18820689   18824534   18832584   18832714   18846339   18849341   18852364   18854426   18925411   18936141   18941203   18941239   18946502   18952897   18959120   18974879   18981086   18981139   18981140   18981228   18981243   18987631   18996347   19008784   19011150   19017981   19017982   19035506   19052722   19060881   19064998   19072551   19073249   19074553   19079173   19085953   19091986   19096031   19098273   19100385   19101032   19107373   19109188   19109190   19109191   19109197   19112093   19122179   19122641   19124725   19130558   19131641   19141183   19155492   19155513   19159824   19165543   19167076   19169359   19171902   19179413   19181857   19187771   19191335   19200341   19211042   19218085   19218193   19218854   19228664   19229991   19230851   19234168   19238529   19246719   19255194   19261929   19262671   19265136   19265148   19265160   19265198   19270711   19272591   19289601   19299700   19299719   19328626   19332531   19342674   19342691   19349620   19357791   19362372   19378012   19380712   19382893   19389932   19398543   19401158   19402754   19405031   19406832   19414781   19414785   19424969   19427685   19433551   19434478   19448144   19461045   19461481   19465907   19478204   19492426   19494325   19501120   19502589   19503602   19508385   19519177   19521507   19525933   19540594   19540914   19542021   19542372   19548630   19553337   19553541   19559408   19561082   19561094   19561102   19561617   19564573   19570822   19585512   19586996   19592497   19595715   19596011   19596768   19596990   19603547   19605353   19608614   19625374   19635918   19635922   19637282   19641135   19657352   19666528   19667044   19681597   19691857   19696201   19710467   19718644   19720755   19721002   19723506   19732774   19732955   19734906   19740386   19752239   19758186   19776284   19778788   19786028   19786067   19786535   19786543   19797072   19805530   19806220   19809160   19809161   19812209   19815878   19816595   19818491   19822644   19823099   19828841   19834009   19834062   19839009   19843690   19846417   19846874   19855398   19858325   19865078   19875664   19879295   19882655   19883619   19887845   19890065   19898473   19901344   19904768   19913447   19914211   19917703   19917774   19919859   19922413   19923461   19925653   19930040   19933194   19933833   19933834   19936231   19950174   19952954   19956717   19965653   19995952   20002786   20007584   20007974   20008536   20018573   20018613   20018674   20018893   20028656   20037584   20038642   20051628   20059544   20061547   20089260   20107166   20107183   20124731   20130211   20130216   20132416   20133493   20148421   20149215   20162551   20164431   20179247   20194715   20196778   20207969   20211628   20213499   20224597   20231693   202651   202969   20304961   20306223   20335569   20345905   20348242   20348922   20351187   20351694   20360853   20362337   20370361   20381591   20387088   20388795   20393111   20393140   20394980   20400501   20404812   20418360   20421474   20424490   20432233   20435932   20442858   20450885   20453108   20465519   20472098   20473304   20473308   20478617   20479237   20483752   20495560   20498653   20501938   20504769   20508155   20510162   20511545   20519121   20522648   20526283   20528914   20531401   20537708   20540783   20547845   20554031   20554880   20566738   20566829   20574076   20576919   20580721   20581153   20585036   20595685   20600022   20608903   20610652   20617171   20620328   20624996   20631308   20637206   20638132   20643339   20643919   20649597   20654686   20657826   20660289   20661259   20668698   20675592   20700129   20708624   20709956   20711192   20720515   20726230   20729214   20732324   20800895   20801528   20804821   20806319   20808781   20810248   20811584   20818396   20819925   20826541   20826748   20837714   20847143   20853174   20855545   20861353   20869044   20876532   20877575   20878353   20886104   20927041   20937844   20939858   20943998   20959459   20966403   20975627   21031135   21035758   21039473   21041647   21042588   21045807   21078270   21078858   21078886   21078906   21084753   21093317   21098223   21098227   21106671   21106850   21115722   21131441   21134836   21148032   21148557   21151968   21152039   21153329   21159162   21169541   21182074   21182089   21197709   21199260   21203418   21205004   21220332   21220426   21221123   21224055   21233280   21236239   21239713   21245496   21264236   21270400   21270629   21272673   21273555   21282509   21289528   21295571   21307291   21307647   21321188   21330606   21330948   21335610   21337316   21339365   21343392   21345313   21346151   21357722   21368092   21372296   21385270   21391988   21392041   21392794   21398616   21402890   21402950   21403587   21419643   21425583   21455984   21460221   21464136   21464300   21474346   21478151   21480215   21482041   21490391   21492746   21497800   21498084   21498664   21506806   21513697   21518783   21525932   21538349   21543518   21547259   21558447   21563297   21567398   21571100   21589869   21593379   21602844   21610198   21612566   21617699   21622562   21622863   21622869   21628003   21628465   21628500   21632720   21633411   21641402   21645538   21646453   21653731   21664694   21666244   21674704   21683771   21685248   21685327   21689009   21690093   21690321   21690387   21695198   21696980   21698299   21701588   21706041   21708993   21712022   21712422   21722182   21730052   21730133   21731762   21733316   21738466   21746857   21756853   21757189   21775438   21782812   21784973   21801874   21802073   21809356   21820318   21820713   21822148   21827211   21827663   21829592   21829705   21846723   21849499   21849675   21858160   21863370   21865055   21865549   21876121   21877248   21880694   21881005   21884699   21887846   21900253   21911421   21918198   21920554   21933654   21935459   21937604   21937985   21949133   21955045   21960563   21965665   21966468   21997473   21999375   22002164   22019135   22025508   22028224   22031891   22031950   22033934   22036947   22038822   22039448   22042868   22045807   22046231   22049214   22062220   22063738   22067909   22073274   22075930   22078883   22095710   22095717   22096480   22099205   22101787   22118374   22123294   22123964   22124111   22139376   22156594   22158869   22160309   22167804   22184724   22188870   22207132   22207622   22210910   22214850   22215738   22225630   22231169   22231517   22235111   22250085   22250086   22253482   22262768   22265692   22272328   22278939   22281426   22297845   22300504   22306056   22307620   22323544   22336013   22354914   22384232   22385341   22394636   22396017   22396536   22422925   22424098   22431236   22431523   22432744   22442158   22451944   22455839   22461698   22465073   22466646   22470535   22474023   22474354   22479513   22489868   22491257   22493489   22494046   22496641   22509021   22511319   22511718   22511870   22516259   22516959   22523073   22529298   22532668   22537289   22541070   22556332   22560444   22562723   22565313   22569257   22575970   22575992   22580897   22582345   22586037   22586114   22596222   22610280   22610400   22615562   22615780   22617167   22622619   22627090   22634181   22634614   22642811   22642907   22652603   22659029   22662179   22666391   22675203   22677551   22677561   22703984   22713470   22713870   22724018   2272660   22730545   22733747   22733781   22745710   22750431   22751700   22771700   2277589   22777843   22781360   22789921   22796522   22797797   22804476   22806454   22807450   22808254   22808256   22812678   22821982   22825738   22826216   22826298   22840842   22841886   22842069   22848581   22851489   22870312   22874765   22890118   22890140   22891325   22895517   22895704   22896604   22898816   22899994   22902233   22905218   22908323   22908333   22911769   22927048   22927440   22931089   22933629   22943202   22951730   22955282   22956579   22958386   22962600   22962610   22970242   22972924   22981705   22983353   22995462   22996399   23000425   23000830   23002437   23018455   23019321   23019612   23023391   23028952   23034650   23043959   23045603   23055522   23071670   23071817   23075507   23077245   23079657   23091640   23092428   23103505   23108585   23112187   23125310   23127406   23135279   23141927   23144170   23147039   23151845   23162016   23184990   23188082   23201091   23203928   23207150   23209313   23209321   23212905   23223360   23241411   23264656   23269975   23275600   23297396   23316068   23319736   23322736   23348507   23365080   23413427   23436933   2509612   2572648   2631797   2848174   2998065   325138   326565   326955   333293   3397181   342603   342667   359704   368244   3884708   3886795   478638   4877918   501093   627714   6491291   681749   6985638   7365261   7521367   7622247   7650365   7822029   7829969   7849398   792337   7927709   8037746   8330899   8335946   8428530   8606102   8654505   8765479   8838309   8890215   8921956   8982246   9043949   9108410   915285   9177560   9321479   9403730   9403834   9596750   9851930   9989976 RGD Disease Portals Tlr4 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cancer Phenotypes Biological Process Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Neurological Diseases Neurological Pathways Neurological Phenotypes Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Biological Process Respiratory Diseases Respiratory Pathways Respiratory Phenotypes Genomics Comparative Map Data Tlr4   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,827,811 - 66,842,797 + NCBI Mouse cM Map 4 34.66   NCBI Mouse Celera Assembly 4 65,431,141 - 65,446,127 + NCBI Mouse Genome Assembly Build 37 4 66,488,845 - 66,503,831 + NCBI Mouse Genome Assembly Build 36.1 4 66,488,845 - 66,503,831 + NCBI Mouse Cytogenetic Map 4 C1   NCBI TLR4   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 9 120,478,618 - 120,491,936 + NCBI Human Genome Assembly HuRef 9 90,084,535 - 90,097,850 + NCBI Human Genome Assembly GRCh37 9 120,466,453 - 120,479,769 + NCBI Human Genome Assembly Build 36 9 119,506,431 - 119,519,589 + NCBI Human Cytogenetic Map 9 q33.1   NCBI Human Genome Assembly 9 117,546,137 - 117,556,781   NCBI Tlr4   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 5 q24   NCBI RGSC Genome Assembly v5.0 5 86,690,670 - 86,704,302 + NCBI RGSC Genome Assembly v3.4 5 83,564,100 - 83,577,735 + NCBI Rat Celera Assembly 5 79,045,293 - 79,058,928 + NCBI Genome Assembly 3.1 5 83,569,212 - 83,582,848 + NCBI RH 3.4 5 643.7   RGD Position Markers AF095353   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,841,570 - 66,841,654   UniSTS Mouse Whitehead/MRC_RH 4 1010.8   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse Celera Assembly 4 65,444,900 - 65,444,984   UniSTS Mouse Genome Assembly Build 37 4 66,502,604 - 66,502,688   UniSTS Mouse Cytogenetic Map 4 C1   UniSTS UniSTS:234941   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,841,636 - 66,841,856   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse Celera Assembly 4 65,444,966 - 65,445,186   UniSTS Mouse Genome Assembly Build 37 4 66,502,670 - 66,502,890   UniSTS Mouse Cytogenetic Map 4 C1   UniSTS PMC289161P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,841,119 - 66,841,421   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse Celera Assembly 4 65,444,449 - 65,444,751   UniSTS Mouse Genome Assembly Build 37 4 66,502,153 - 66,502,455   UniSTS Mouse Cytogenetic Map 4 C1   UniSTS Tlr4   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,841,186 - 66,841,371   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse Celera Assembly 4 65,444,516 - 65,444,701   UniSTS Mouse Genome Assembly Build 37 4 66,502,097 - 66,502,216   UniSTS Mouse Cytogenetic Map 4 C1   UniSTS Tlr4   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,841,063 - 66,841,182   UniSTS Mouse cM Map 4 33.0   UniSTS Mouse Celera Assembly 4 65,444,393 - 65,444,512   UniSTS Mouse Genome Assembly Build 37 4 66,502,097 - 66,502,216   UniSTS Mouse Cytogenetic Map 4 C1   UniSTS Tlr4   Map Chr Position Strand Source Mouse cM Map 4 33.0   UniSTS Mouse Cytogenetic Map 4 C1   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1301792 Hdlq10_m HDL QTL 10 (mouse) Not determined 4 35872579 69872725 Mouse 1357501 Manln4_m mandible length 4 (mouse) Not determined 4 36324953 70325088 Mouse 1300977 Mopkd1_m modifier of polycystic kidney disease progression 1 (mouse) Not determined 4 36563711 70563839 Mouse 1357904 Hdl36_m HDL level 36 (mouse) Not determined 4 36563711 70563839 Mouse 1357672 Marif1_m macrophage-associated risk inflammatory factor 1 (mouse) Not determined 4 37696597 71696723 Mouse 4141475 Dbsq6_m diabetes susceptibility QTL 6 (mouse) Not determined 4 38263802 72263950 Mouse 1301040 Remslp1_m rapid eye movement sleep 1 (mouse) Not determined 4 39782251 73782366 Mouse 4141718 Imraq1_m immune response to AAV2 QTL 1 (mouse) Not determined 4 42415112 76415253 Mouse 1301786 Bpq3_m blood pressure QTL 3 (mouse) Not determined 4 42415112 76415253 Mouse 4141282 Bwtq9_m body weight QTL 9 (mouse) Not determined 4 42565384 76565529 Mouse 1558948 Ath8_m atherosclerosis 8 (mouse) Not determined 4 45671314 104972403 Mouse 1357486 Bmch2_m bone mechanical trait 2 (mouse) Not determined 4 45722797 102244445 Mouse 1357895 Ctrcts_m cataract severity (mouse) Not determined 4 45722797 138171357 Mouse 1301941 Mmtg1_m modifier of mammary tumor growth 1 (mouse) Not determined 4 46026328 80026475 Mouse 1301625 Tshp5_m tooth shape 5 (mouse) Not determined 4 46026328 80026475 Mouse 1357578 Manln5_m mandible length 5 (mouse) Not determined 4 46026328 80026475 Mouse 1301194 Manz3_m mandible size 3 (mouse) Not determined 4 46026328 80026475 Mouse 1302077 Bglq4_m body growth late QTL 4 (mouse) Not determined 4 46026328 80026475 Mouse 4141810 Ccmp4_m cerebellar cAMP 4 (mouse) Not determined 4 49843059 83843205 Mouse 1301871 Frp1_m free running period 1 (mouse) Not determined 4 49843059 83843205 Mouse 1301213 Lgth3_m body length 3 (mouse) Not determined 4 49843059 83843205 Mouse 1301995 Lprm1_m lymphoproliferation modifier 1 (mouse) Not determined 4 49843059 83843205 Mouse 4141900 Skts-fp1_m skin tumor susceptibility in FVB and PWK 1 (mouse) Not determined 4 53563711 123838630 Mouse 1357507 Synch2_m synechia 2 (mouse) Not determined 4 59872944 93873091 Mouse 1301190 Cd4ts2_m CD4 T cell subset 2 (mouse) Not determined 4 59872944 93873091 Mouse 4141746 Vms3_m viral myocarditis susceptibility locus 3 (mouse) Not determined 4 63347193 97347352 Mouse 1357870 Pfat1_m predicted fat percentage 1 (mouse) Not determined 4 63347193 97347352 Mouse 1300697 Sle2_m systemic lupus erythmatosus susceptibility 2 (mouse) Not determined 4 65636691 99636827 Mouse 1301757 Tlsr4_m thymic lymphoma suppressor region 4 (mouse) Not determined 4 66484797 100484925 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_021297 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01036550 (Get FASTA) Search GEO for Microarray Profiles   AF095353 (Get FASTA) Search GEO for Microarray Profiles   AF110133 (Get FASTA) Search GEO for Microarray Profiles   AF177767 (Get FASTA) Search GEO for Microarray Profiles   AF185285 (Get FASTA) Search GEO for Microarray Profiles   AK014533 (Get FASTA) Search GEO for Microarray Profiles   AK030348 (Get FASTA) Search GEO for Microarray Profiles   AK154297 (Get FASTA) Search GEO for Microarray Profiles   AK170566 (Get FASTA) Search GEO for Microarray Profiles   AL805946 (Get FASTA) Search GEO for Microarray Profiles   BC029856 (Get FASTA) Search GEO for Microarray Profiles   BX649609 (Get FASTA) Search GEO for Microarray Profiles   CH466527 (Get FASTA) Search GEO for Microarray Profiles   JX878358 (Get FASTA) Search GEO for Microarray Profiles   JX878359 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_021297 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_067272 Peptide Label: precursor Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 66,827,811 - 66,842,797 + ENTREZGENE Mouse cM Map 4   + ENTREZGENE Mouse Celera Assembly 4 65,431,141 - 65,446,127 + RGD Mouse Genome Assembly Build 37 4 66,488,845 - 66,503,831 + RGD Protein Sequences Protein RefSeqs NP_067272 (Get FASTA) GenBank Protein AAC99411 (Get FASTA)   AAD29272 (Get FASTA)   AAF04278 (Get FASTA)   AAF05317 (Get FASTA)   AAH29856 (Get FASTA)   AGA16685 (Get FASTA)   AGA16686 (Get FASTA)   BAE32498 (Get FASTA)   CAD83014 (Get FASTA)   EDL31078 (Get FASTA)   Q9QUK6 (Get FASTA) Promoters RGD ID: 6836519 Promoter ID: MM_KWN:38040 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: 3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen Transcripts: OTTMUST00000000668,   OTTMUST00000000669,   OTTMUST00000000670,   OTTMUST00000020618 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 4 66,488,456 - 66,488,956 + MPROMDB RGD ID: 6877216 Promoter ID: EPDNEW_M2059 Type: preliminary Name: Tlr4_1 Description: toll-like receptor 4 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 4 66,488,643 - 66,488,703   EPDNEW Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000039005 ENTREZGENE Ensembl Protein ENSMUSP00000045770 ENTREZGENE Ensembl Transcript ENSMUST00000048096 ENTREZGENE Entrez Gene 21898 ENTREZGENE Germonline ENSMUSG00000039005 HomoloGene Group ID 41317 ENTREZGENE InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot   TIR_dom UniProtKB/Swiss-Prot   TLR4 UniProtKB/Swiss-Prot   Toll-like_receptor UniProtKB/Swiss-Prot IPI IPI00131730 UniProtKB/Swiss-Prot KEGG Report mmu:21898 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:96824 ENTREZGENE PANTHER PTHR24365:SF9 UniProtKB/Swiss-Prot Pfam TIR UniProtKB/Swiss-Prot PharmGKB TLR4 RGD PIRSF Toll-like_receptor UniProtKB/Swiss-Prot PROSITE TIR UniProtKB/Swiss-Prot SMART LRRCT UniProtKB/Swiss-Prot   TIR UniProtKB/Swiss-Prot Superfamily-SCOP TIR UniProtKB/Swiss-Prot UniGene Mm.38049 ENTREZGENE UniProt A2BHU8_MOUSE UniProtKB/TrEMBL   L0CL36_MOUSE UniProtKB/TrEMBL   Q3U4D4_MOUSE UniProtKB/TrEMBL   Q8K2T5_MOUSE UniProtKB/TrEMBL   TLR4_MOUSE UniProtKB/Swiss-Prot

More on Tlr4 Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 737014 Created: 2004-02-06 Species: Mus musculus Last Modified: 2013-05-14 Status: ACTIVE