Tlr4 (toll-like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll-like receptor 4) Mus musculus
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Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 737014
MGI Page MGI
Description: Enables lipopolysaccharide immune receptor activity. Involved in several processes, including positive regulation of defense response; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of cellular biosynthetic process; and response to bacterium. Located in plasma membrane. Part of receptor complex. Is expressed in several structures, including early embryo; genitourinary system; inner cell mass; intestine; and skin. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: lipopolysaccharide response; Lps; Ly87; Ran/M1; Ras; Rasl2-8; Toll like receptor 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)EnsemblGRCm39 Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBIMGSCv36mm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (ISO)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IEP,IMP,ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
acute pancreatitis  (IEP)
Acute Tubulointerstitial Nephritis  (IMP)
Acute-On-Chronic Liver Failure  (ISO)
Alcoholic Fatty Liver  (IMP)
allergic conjunctivitis  (IMP,ISO)
allergic contact dermatitis  (IMP,ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (IMP,ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (IDA,IMP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (IMP)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (IMP)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IMP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (IMP,ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (IEP,ISO)
Dysbiosis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP,IMP,ISO)
Entamoebiasis  (IMP)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (IEP)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (IEP)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial mediterranean fever  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (ISO)
Fungal Keratitis  (IMP)
genetic disease  (ISO)
glomerulonephritis  (IDA,IMP)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IMP)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (IMP,ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (IAGP,ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (IEP,IMP,ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (IEP,IMP,ISO)
learning disability  (ISO)
leptospirosis  (IMP)
liver cirrhosis  (ISO)
Liver Injury  (IMP)
Liver Reperfusion Injury  (IEP,IMP,ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (IEP,IMP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (IEP)
meningococcal meningitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IMP,ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
obesity  (IAGP,ISO)
Ocular Onchocerciasis  (IMP)
Optic Nerve Injuries  (IEP)
Oral Lichen Planus  (ISO)
otitis media  (IMP,ISO)
Otitis Media with Effusion  (IMP)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Painful Neuropathy  (IMP)
pancreatitis  (IMP,ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (IEP)
pneumonia  (IMP,ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (IMP,ISO)
psoriasis  (ISO)
pulmonary edema  (IMP)
pulmonary emphysema  (IAGP,IMP)
pulmonary fibrosis  (IMP)
pulmonary hypertension  (IMP)
pulmonary tuberculosis  (ISO)
pulpitis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (IMP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (IMP,ISO)
Retina Reperfusion Injury  (IMP)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
severe COVID-19  (ISO)
sinusitis  (IMP,ISO)
Spinal Cord Injuries  (IMP)
Spinal Cord Reperfusion Injury  (ISO)
sporotrichosis  (IMP)
squamous cell carcinoma  (ISO)
Stable Angina  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (IMP)
temporal arteritis  (ISO)
Transplant Rejection  (IMP)
tuberculosis  (IMP)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (IMP)
urinary tract infection  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (IEP)
vitiligo  (ISO)
Wallerian Degeneration  (IAGP)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7alpha-hydroxycholesterol  (ISO)
acetamide  (ISO)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
Alternaramide  (EXP)
aluminium hydroxide  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
ampicillin  (EXP)
anethole  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
artesunate  (ISO)
aspalathin  (ISO)
astaxanthin  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP)
atrazine  (EXP)
auranofin  (EXP)
azathioprine  (EXP)
baicalin  (EXP,ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (EXP)
berberine  (EXP,ISO)
Bergenin  (EXP)
Besigomsin  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
Bisibuthiamine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP,ISO)
boldenone  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
casticin  (ISO)
catalpol  (EXP)
ceftaroline  (ISO)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chaetoglobosin A  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (ISO)
chrysin  (ISO)
cirsilineol  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
crocin-1  (ISO)
cudratricusxanthone A  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
D-glucose  (EXP,ISO)
DAPT  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dienogest  (ISO)
dihydrogen  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
erythromycin A  (EXP)
esculetin  (EXP)
ethanol  (EXP,ISO)
ethion  (EXP)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
euxanthone  (ISO)
Fargesin  (EXP)
ferric oxide  (EXP)
ferroheme b  (EXP)
ferulic acid  (EXP)
fisetin  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (EXP)
fructose  (EXP,ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
galangin  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
ganglioside GM1  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
genkwanin  (ISO)
gentamycin  (ISO)
geraniol  (EXP)
Ginkgolide A  (EXP)
ginsenoside Re  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycerol  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
halothane  (EXP)
Harpagide  (EXP)
helenalin  (EXP)
heme b  (EXP)
hexadecanoic acid  (EXP)
hyaluronic acid  (EXP,ISO)
hydrogen cyanide  (EXP)
hydroquinone  (EXP)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
irinotecan  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoamylol  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
Kukoamine B  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactulose  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lidocaine  (ISO)
linsidomine  (EXP)
lipophosphoglycan  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithium chloride  (ISO)
LY294002  (EXP)
lycopene  (EXP,ISO)
magnesium dihydroxide  (EXP)
malathion  (EXP)
melatonin  (EXP,ISO)
melittin  (EXP)
melphalan  (ISO)
mesalamine  (EXP)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
metronidazole  (EXP)
mirabegron  (ISO)
mirtazapine  (ISO)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (EXP)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (ISO)
Morroniside  (EXP)
muramyl dipeptide  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenol  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
neomycin  (EXP)
nerolidol  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicorandil  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (EXP)
omeprazole  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (ISO)
perampanel  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (EXP)
phosphoramide mustard  (ISO)
picropodophyllotoxin  (EXP)
pipoxolan  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP)
procyanidin B1  (ISO)
progesterone  (ISO)
propofol  (EXP)
puerarin  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (ISO)
SB 431542  (ISO)
scoparone  (EXP)
scopoletin  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium propionate  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
tartrazine  (ISO)
tectorigenin  (EXP)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thiamine(1+) chloride  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
Timosaponin b ii  (EXP)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP)
toluene  (EXP)
trans-anethole  (ISO)
trichloroethene  (EXP)
tropisetron  (ISO)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
Vinpocetine  (ISO)
vitamin D  (EXP,ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IMP)
astrocyte development  (IMP)
B cell proliferation  (IMP)
B cell proliferation involved in immune response  (IMP)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (IDA,IMP,ISO,TAS)
cellular response to lipoteichoic acid  (IMP)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IGI,ISO)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to retinoic acid  (ISO)
cellular response to type II interferon  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (IBA,IMP)
detection of lipopolysaccharide  (IBA,IDA,ISO,TAS)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
ERK1 and ERK2 cascade  (IDA)
gene expression  (IMP)
immune response  (IEA)
immune system process  (IEA)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (IBA,IMP)
innate immune response  (TAS)
innate immune response-activating signaling pathway  (ISO)
intestinal epithelial structure maintenance  (IMP)
JNK cascade  (IDA,IGI)
leukotriene metabolic process  (ISO)
lipopolysaccharide-mediated signaling pathway  (IDA,IGI,ISO)
lymphocyte proliferation  (IMP)
macrophage activation  (ISO,ISS,TAS)
mast cell activation  (NAS)
MHC class II biosynthetic process  (IMP)
microglia differentiation  (IMP)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IBA,IGI,ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of interleukin-17 production  (IMP)
negative regulation of interleukin-23 production  (IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of tumor necrosis factor production  (IMP)
negative regulation of type II interferon production  (IMP)
neurogenesis  (IMP)
nitric oxide biosynthetic process  (IMP)
nitric oxide production involved in inflammatory response  (IMP)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA)
phagocytosis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IDA,ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (IDA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IGI,ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (IGI)
positive regulation of gene expression  (IGI,IMP,ISO)
positive regulation of inflammatory response  (IGI,ISO)
positive regulation of interferon-alpha production  (IDA)
positive regulation of interferon-beta production  (IDA,IMP)
positive regulation of interleukin-1 beta production  (IDA,ISO)
positive regulation of interleukin-1 production  (IDA,NAS)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (IDA,ISO)
positive regulation of interleukin-13 production  (NAS)
positive regulation of interleukin-6 production  (IDA,IMP,ISO,NAS)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA,IGI)
positive regulation of lymphocyte proliferation  (IMP)
positive regulation of macrophage activation  (IGI)
positive regulation of macrophage cytokine production  (IDA,IMP)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of MHC class II biosynthetic process  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (IGI,IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA)
positive regulation of NLRP3 inflammasome complex assembly  (IDA)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of platelet activation  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress-activated MAPK cascade  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (IDA,IMP,ISO)
positive regulation of type II interferon production  (IMP)
regulation of dendritic cell cytokine production  (IDA)
regulation of inflammatory response  (IMP)
regulation of tumor necrosis factor production  (ISO)
response to activity  (ISO)
response to bacterium  (IMP)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to gold nanoparticle  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (IGI,IMP,ISO)
response to oxidative stress  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to toxic substance  (ISO)
signal transduction  (IEA)
skeletal muscle contraction  (ISO)
stress-activated MAPK cascade  (IDA)
toll-like receptor 4 signaling pathway  (IBA,IDA,ISO)
toll-like receptor signaling pathway  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (IGI)
wound healing involved in inflammatory response  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal airway responsiveness  (IAGP)
abnormal artery morphology  (IAGP)
abnormal bile salt level  (IAGP)
abnormal bone structure  (IAGP)
abnormal cecum morphology  (IEA)
abnormal chemokine secretion  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating leptin level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal enterocyte differentiation  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal fibroblast proliferation  (IAGP)
abnormal gas homeostasis  (IAGP)
abnormal glial cell apoptosis  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulocyte physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle cell glucose uptake  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal phagocyte morphology  (IAGP)
abnormal proximal convoluted tubule brush border morphology  (IAGP)
abnormal pulmonary alveolar duct morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary elastic fiber morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina progenitor cell morphology  (IAGP)
abnormal retina rod bipolar cell morphology  (IAGP)
abnormal retina rod cell morphology  (IAGP)
abnormal spleen weight  (IAGP)
abnormal susceptibility to atherosclerosis  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal uterus morphology  (IEA)
abnormal vascular wound healing  (IAGP)
atherosclerotic lesions  (IAGP)
brain ischemia  (IAGP)
cellular necrosis  (IEA)
colitis  (IAGP)
decreased acute inflammation  (IAGP)
decreased angiogenesis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased colon length  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased eye pigmentation  (IEA)
decreased fat cell size  (IAGP)
decreased hemoglobin content  (IAGP)
decreased hepatocyte apoptosis  (IAGP)
decreased IgG3 level  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-beta secretion  (IEA)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased macrophage apoptosis  (IEA)
decreased macrophage cytokine production  (IEA)
decreased memory B cell number  (IEA)
decreased neuron apoptosis  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bone fracture  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to Orthomyxoviridae infection  (IAGP)
decreased susceptibility to weight loss  (IAGP)
decreased tail pigmentation  (IEA)
decreased tumor necrosis factor secretion  (IAGP)
dilated pulmonary alveolar duct  (IAGP)
dilated renal tubule  (IAGP)
diluted coat color  (IEA)
enlarged cecum  (IEA)
enlarged lung  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged uterus  (IEA)
focal hepatic necrosis  (IAGP)
hyperoxia  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
improved glucose tolerance  (IAGP)
increased adiponectin level  (IAGP)
increased apoptosis  (IAGP)
increased B-1 B cell number  (IAGP)
increased bone mass  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased cell death  (IEA)
increased circulating interleukin-6 level  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased lung compliance  (IAGP)
increased oxygen consumption  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to Poxviridae infection induced morbidity/mortality  (IAGP)
increased thermal nociceptive threshold  (IAGP)
large intestinal inflammation  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IEA)
polyphagia  (IAGP)
pulmonary edema  (IAGP)
rectal hemorrhage  (IAGP)
renal cast  (IAGP)
renal tubular necrosis  (IAGP)
References

References - curated
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63. Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis. Halfhide CP, etal., Thorax. 2009 Sep;64(9):798-805. Epub 2009 Jun 3.
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65. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
66. Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo. He D, etal., Int Immunopharmacol. 2016 Jun;35:201-209. doi: 10.1016/j.intimp.2016.03.032. Epub 2016 Apr 16.
67. Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study. He Z, etal., Respir Res. 2009 Dec 18;10:126.
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69. Expression of toll-like receptors in chronic otitis media and cholesteatoma. Hirai H, etal., Int J Pediatr Otorhinolaryngol. 2013 May;77(5):674-6. doi: 10.1016/j.ijporl.2013.01.010. Epub 2013 Feb 4.
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74. Potential role of macrophages in experimental keratomycosis. Hu J, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2087-94. doi: 10.1167/iovs.07-1237. Epub 2008 Dec 13.
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86. Inhibition of Toll-like receptor 4 with vasoactive intestinal peptide attenuates liver ischemia-reperfusion injury. Jiang W, etal., Transplant Proc. 2011 Jun;43(5):1462-7.
87. A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population. Jiang ZC, etal., Tumour Biol. 2014 Dec;35(12):12345-52. doi: 10.1007/s13277-014-2547-z. Epub 2014 Sep 2.
88. Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis. Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
89. Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea. Jin X, etal., Cornea. 2007 Aug;26(7):847-52.
90. Expression of toll-like receptors in the Fusarium solani infected cornea. Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
91. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
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93. Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
94. TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients. Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
95. Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques. Katsargyris A, etal., Expert Opin Ther Targets. 2010 Jan;14(1):1-10. doi: 10.1517/14728220903401294.
96. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
97. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
98. Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts. Kim K, etal., Clin Nutr. 2013 Oct;32(5):855-62. doi: 10.1016/j.clnu.2012.11.026. Epub 2013 Jan 23.
99. Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia? Kim YM, etal., Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):921-7.
100. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
101. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
102. Salvage effect of E5564, Toll-like receptor 4 antagonist on d-galactosamine and lipopolysaccharide-induced acute liver failure in rats. Kitazawa T, etal., J Gastroenterol Hepatol. 2010 May;25(5):1009-12. doi: 10.1111/j.1440-1746.2009.06145.x.
103. Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
104. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
105. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Kolek MJ, etal., Am Heart J. 2004 Dec;148(6):1034-40.
106. TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. Koreck A, etal., Dermatology. 2006;213(3):267-9.
107. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. Kuang X, etal., Eur J Pharmacol. 2012 Feb 15;676(1-3):51-6. doi: 10.1016/j.ejphar.2011.11.037. Epub 2011 Dec 7.
108. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
109. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
110. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. Lartigue A, etal., J Immunol. 2009 Nov 15;183(10):6207-16. doi: 10.4049/jimmunol.0803219. Epub 2009 Oct 19.
111. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. Lauriello M, etal., Int J Otolaryngol. 2012;2012:925164. doi: 10.1155/2012/925164. Epub 2012 Apr 10.
112. Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. Leal SM Jr, etal., PLoS Pathog. 2010 Jul 1;6:e1000976. doi: 10.1371/journal.ppat.1000976.
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115. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
116. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. Li DQ, etal., J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2. doi: 10.1016/j.jaci.2011.06.041. Epub 2011 Aug 6.
117. Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Li H, etal., Anesthesiology. 2010 Sep;113(3):619-29.
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119. Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats. Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
120. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways. Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
121. Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
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129. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Lubbad A, etal., Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11.
130. Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma. Lun SW, etal., J Clin Immunol. 2009 May;29(3):330-42. Epub 2008 Dec 6.
131. Evaluation of importance of Toll-like receptor 4 in acute Streptococcus pneumoniae sinusitis in mice. Luxameechanporn T, etal., Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):1001-6.
132. Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage. Ma CX, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1575-81.
133. The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4. Maldonado-Bernal C, etal., Parasite Immunol. 2005 Apr;27(4):127-37.
134. Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles. Mano SS, etal., Int J Mol Sci. 2013 Jun 26;14(7):13154-70. doi: 10.3390/ijms140713154.
135. Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. Martin SF, etal., J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.
136. Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. Meguro A, etal., Ann Rheum Dis. 2008 May;67(5):725-7. doi: 10.1136/ard.2007.079871.
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138. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
139. MGDs mouse GO annotations MGD data from the GO Consortium
140. MGD IEA MGD IEA
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142. In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
143. Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma. Minmin S, etal., PLoS One. 2011 Apr 29;6(4):e19466. doi: 10.1371/journal.pone.0019466.
144. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Minoretti P, etal., Neurosci Lett. 2006 Jan 2;391(3):147-9. Epub 2005 Sep 12.
145. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Mohammad MK, etal., Int Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25.
146. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
147. Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population. Najmi N, etal., Tissue Antigens. 2010 Aug;76(2):102-9. Epub 2010 Apr 8.
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149. Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation. Ohara K, etal., J Neuroinflammation. 2013 Nov 23;10:139. doi: 10.1186/1742-2094-10-139.
150. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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156. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
157. Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis. Peng Y, etal., Surgery. 2008 May;143(5):679-85. doi: 10.1016/j.surg.2008.01.005.
158. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
159. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Poggi M, etal., Diabetologia. 2007 Apr 11;.
160. TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid. Prabha C, etal., Immunol Lett. 2008 Apr 15;117(1):26-34. Epub 2007 Dec 3.
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162. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
163. Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia. Reismann P, etal., J Neurol. 2004 Jul;251(7):853-8.
164. Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. Ren MY and Wu XY, Parasite Immunol. 2011 Jan;33(1):25-33. doi: 10.1111/j.1365-3024.2010.01247.x.
165. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Reyna SM, etal., Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.
166. Mouse MP Annotation Import Pipeline RGD automated import pipeline
167. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
168. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
169. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
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171. Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Rudofsky G Jr, etal., Diabetes Care. 2004 Jan;27(1):179-83.
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174. Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients. Sadik NA, etal., Arch Virol. 2015 Sep;160(9):2181-95. doi: 10.1007/s00705-015-2493-0. Epub 2015 Jun 23.
175. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
176. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
177. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Saraswathy S, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3680-6. doi: 10.1167/iovs.09-4575. Epub 2010 Mar 5.
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179. Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
180. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Schmidt M, etal., Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.
181. Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy. Senthilselvan A, etal., Ann Allergy Asthma Immunol. 2008 May;100(5):463-8.
182. Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
183. TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
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185. TLR4 links innate immunity and fatty acid-induced insulin resistance. Shi H, etal., J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.
186. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
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188. Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis. Shirai Y, etal., J Gastroenterol Hepatol. 2013 Apr;28(4):723-30. doi: 10.1111/jgh.12112.
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190. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
191. Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients. Singh K, etal., Biomed Res Int. 2013;2013:318686. doi: 10.1155/2013/318686. Epub 2013 Jul 11.
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196. Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population. Suh W, etal., Mol Vis. 2011;17:2343-8. Epub 2011 Aug 31.
197. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Summers SA, etal., Kidney Int. 2010 Sep 15.
198. Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
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200. Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. Takano Y, etal., Am J Ophthalmol. 2012 Nov;154(5):825-832.e1. doi: 10.1016/j.ajo.2012.03.050. Epub 2012 Jul 24.
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PMID:30541786   PMID:30550933   PMID:30555556   PMID:30562386   PMID:30575775   PMID:30575787   PMID:30626747   PMID:30635238   PMID:30650348   PMID:30661789   PMID:30664156   PMID:30671932  
PMID:30672380   PMID:30689886   PMID:30710046   PMID:30718548   PMID:30720218   PMID:30729183   PMID:30733282   PMID:30737385   PMID:30753099   PMID:30753344   PMID:30756214   PMID:30785200  
PMID:30794438   PMID:30811271   PMID:30814309   PMID:30824326   PMID:30830879   PMID:30848676   PMID:30850533   PMID:30862819   PMID:30873007   PMID:30909920   PMID:30915370   PMID:30922122  
PMID:30928727   PMID:30952815   PMID:30953645   PMID:30958891   PMID:30979817   PMID:30992366   PMID:31065973   PMID:31067461   PMID:31081244   PMID:31086261   PMID:31090056   PMID:31091120  
PMID:31092437   PMID:31110312   PMID:31115903   PMID:31118418   PMID:31119834   PMID:31132191   PMID:31141808   PMID:31142629   PMID:31173169   PMID:31189722   PMID:31201418   PMID:31225947  
PMID:31226171   PMID:31228609   PMID:31236964   PMID:31270160   PMID:31271872   PMID:31284755   PMID:31293597   PMID:31302461   PMID:31309100   PMID:31328162   PMID:31348811   PMID:31350848  
PMID:31369614   PMID:31375667   PMID:31382038   PMID:31388087   PMID:31395343   PMID:31433296   PMID:31433298   PMID:31442262   PMID:31451099   PMID:31462144   PMID:31467416   PMID:31489613  
PMID:31489644   PMID:31495009   PMID:31507610   PMID:31526567   PMID:31539158   PMID:31590042   PMID:31590685   PMID:31601454   PMID:31607480   PMID:31611307   PMID:31649671   PMID:31650683  
PMID:31676858   PMID:31696221   PMID:31700009   PMID:31717470   PMID:31729371   PMID:31732468   PMID:31733121   PMID:31733580   PMID:31736414   PMID:31756421   PMID:31771613   PMID:31784084  
PMID:31785241   PMID:31796334   PMID:31796867   PMID:31802434   PMID:31822562   PMID:31825829   PMID:31827178   PMID:31836429   PMID:31851905   PMID:31857157   PMID:31865791   PMID:31884387  
PMID:31898723   PMID:31901258   PMID:31907354   PMID:31971040   PMID:31980634   PMID:31983426   PMID:31989925   PMID:31993047   PMID:32003008   PMID:32007503   PMID:32014896   PMID:32046403  
PMID:32059688   PMID:32073735   PMID:32094297   PMID:32128893   PMID:32130574   PMID:32135028   PMID:32144270   PMID:32150572   PMID:32151799   PMID:32162777   PMID:32170061   PMID:32172666  
PMID:32173863   PMID:32182218   PMID:32205424   PMID:32210480   PMID:32212902   PMID:32234476   PMID:32244316   PMID:32259563   PMID:32268093   PMID:32298648   PMID:32321985   PMID:32341377  
PMID:32343455   PMID:32347583   PMID:32372402   PMID:32375035   PMID:32378734   PMID:32403973   PMID:32403975   PMID:32412103   PMID:32415675   PMID:32424099   PMID:32424365   PMID:32429710  
PMID:32435246   PMID:32436368   PMID:32437795   PMID:32438368   PMID:32459842   PMID:32464206   PMID:32484881   PMID:32503644   PMID:32515223   PMID:32515732   PMID:32521253   PMID:32529819  
PMID:32538139   PMID:32554809   PMID:32555351   PMID:32567013   PMID:32580932   PMID:32580945   PMID:32610084   PMID:32611241   PMID:32632165   PMID:32662520   PMID:32662806   PMID:32678947  
PMID:32708537   PMID:32726591   PMID:32726802   PMID:32731255   PMID:32732870   PMID:32745117   PMID:32755994   PMID:32758588   PMID:32763359   PMID:32780740   PMID:32788720   PMID:32796317  
PMID:32799375   PMID:32814631   PMID:32826878   PMID:32889432   PMID:32894580   PMID:32905776   PMID:32910992   PMID:32912327   PMID:32912899   PMID:32914937   PMID:32924602   PMID:32932915  
PMID:32939611   PMID:32958053   PMID:32964428   PMID:32972755   PMID:32973091   PMID:32975614   PMID:32979744   PMID:32988867   PMID:32989649   PMID:33002664   PMID:33008952   PMID:33042124  
PMID:33060562   PMID:33093516   PMID:33123130   PMID:33123170   PMID:33123905   PMID:33127391   PMID:33128793   PMID:33132187   PMID:33140555   PMID:33148715   PMID:33156707   PMID:33174138  
PMID:33193308   PMID:33193406   PMID:33199767   PMID:33207218   PMID:33212011   PMID:33214151   PMID:33216117   PMID:33229758   PMID:33234677   PMID:33236134   PMID:33239787   PMID:33274576  
PMID:33279598   PMID:33283918   PMID:33308902   PMID:33314778   PMID:33318075   PMID:33334791   PMID:33344654   PMID:33369167   PMID:33412104   PMID:33422341   PMID:33469517   PMID:33479745  
PMID:33487119   PMID:33495514   PMID:33508081   PMID:33519799   PMID:33542720   PMID:33549727   PMID:33567279   PMID:33589625   PMID:33601314   PMID:33655339   PMID:33687949   PMID:33711076  
PMID:33727039   PMID:33746957   PMID:33752705   PMID:33760172   PMID:33763070   PMID:33763386   PMID:33789141   PMID:33792561   PMID:33797542   PMID:33802409   PMID:33846230   PMID:33860064  
PMID:33895168   PMID:33907855   PMID:33931988   PMID:33938125   PMID:33949057   PMID:33958642   PMID:33963333   PMID:33970188   PMID:33971268   PMID:33989718   PMID:33990675   PMID:34014921  
PMID:34020266   PMID:34025643   PMID:34031144   PMID:34034779   PMID:34047945   PMID:34072916   PMID:34076894   PMID:34078799   PMID:34087422   PMID:34102854   PMID:34139379   PMID:34167455  
PMID:34174335   PMID:34206257   PMID:34215697   PMID:34216140   PMID:34223915   PMID:34233151   PMID:34261477   PMID:34291735   PMID:34321536   PMID:34329381   PMID:34360700   PMID:34367191  
PMID:34373761   PMID:34376755   PMID:34395439   PMID:34397115   PMID:34400677   PMID:34405787   PMID:34429343   PMID:34462225   PMID:34504172   PMID:34529751   PMID:34568976   PMID:34592238  
PMID:34613696   PMID:34613801   PMID:34622466   PMID:34659265   PMID:34675215   PMID:34678150   PMID:34689797   PMID:34704575   PMID:34732321   PMID:34745132   PMID:34755600   PMID:34760891  
PMID:34769252   PMID:34780278   PMID:34822994   PMID:34830071   PMID:34867973   PMID:34884634   PMID:34896544   PMID:34943932   PMID:34961984   PMID:34965421   PMID:34965485   PMID:34973395  
PMID:35011620   PMID:35041723   PMID:35043940   PMID:35044724   PMID:35065706   PMID:35082281   PMID:35131445   PMID:35163799   PMID:35169163   PMID:35170388   PMID:35182483   PMID:35237256  
PMID:35245124   PMID:35247611   PMID:35257279   PMID:35263589   PMID:35276460   PMID:35303419   PMID:35314006   PMID:35343654   PMID:35369030   PMID:35385339   PMID:35394816   PMID:35404176  
PMID:35405301   PMID:35417681   PMID:35422759   PMID:35493520   PMID:35568203   PMID:35584674   PMID:35647205   PMID:35648750   PMID:35663944   PMID:35681486   PMID:35690624   PMID:35702793  
PMID:35727636   PMID:35735109   PMID:35761415   PMID:35775122   PMID:35778649   PMID:35787402   PMID:35812397   PMID:35838047   PMID:35840613   PMID:35844541   PMID:35881547   PMID:35883634  
PMID:35896747   PMID:35903022   PMID:35926455   PMID:35982604   PMID:35989413   PMID:36058417   PMID:36076559   PMID:36079861   PMID:36088483   PMID:36103821   PMID:36115635   PMID:36119026  
PMID:36121866   PMID:36227676   PMID:36233127   PMID:36271559   PMID:36301036   PMID:36377658   PMID:36378153   PMID:36385232   PMID:36400339   PMID:36402251   PMID:36405698   PMID:36415950  
PMID:36426935   PMID:36450338   PMID:36460345   PMID:36461933   PMID:36482445   PMID:36505926   PMID:36555322   PMID:36574533   PMID:36603009   PMID:36603072   PMID:36658449   PMID:36674890  
PMID:36698311   PMID:36701109   PMID:36705251   PMID:36719418   PMID:36736217   PMID:36739425   PMID:36740319   PMID:36764277   PMID:36766838   PMID:36779805   PMID:36801437   PMID:36801998  
PMID:36857178   PMID:36868208   PMID:36876136   PMID:36911699   PMID:36916435   PMID:37028769   PMID:37034342   PMID:37059259   PMID:37085277   PMID:37102696   PMID:37115935   PMID:37150251  
PMID:37150279   PMID:37153546   PMID:37197666   PMID:37283745   PMID:37349313   PMID:37364329   PMID:37463445   PMID:37515333   PMID:37563282   PMID:37567012   PMID:37596575   PMID:37605037  
PMID:37662857   PMID:37664927   PMID:37691112   PMID:37700342   PMID:37715390   PMID:37720226   PMID:37733587   PMID:37752945   PMID:37772812   PMID:37773690   PMID:37819761   PMID:37820669  
PMID:37838079   PMID:37863130   PMID:37975259   PMID:37991487   PMID:38001534   PMID:38102579   PMID:38140398   PMID:38159556   PMID:38182816   PMID:38190982   PMID:38280374   PMID:38299349  
PMID:38326029   PMID:38332381   PMID:38363110   PMID:38422177   PMID:38491103   PMID:38516845  


Genomics

Comparative Map Data
Tlr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)EnsemblGRCm39 Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBIMGSCv36mm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
TLR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9117,704,175 - 117,724,735 (+)EnsemblGRCh38hg38GRCh38
GRCh379120,466,681 - 120,487,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36Build 36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
T2T-CHM13v2.09129,898,286 - 129,918,621 (+)NCBIT2T-CHM13v2.0
Tlr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8585,161,247 - 85,174,882 (+)NCBIGRCr8
mRatBN7.2580,145,867 - 80,159,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl580,145,826 - 80,159,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx582,524,918 - 82,538,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0584,342,217 - 84,355,831 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0584,317,856 - 84,331,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0582,587,424 - 82,601,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl582,587,420 - 82,601,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0586,690,670 - 86,704,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4583,564,100 - 83,577,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1583,569,212 - 83,582,848 (+)NCBI
Celera579,045,293 - 79,058,928 (+)NCBICelera
RH 3.4 Map5643.7RGD
Cytogenetic Map5q24NCBI
Tlr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541910,191,120 - 10,202,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541910,190,937 - 10,201,896 (-)NCBIChiLan1.0ChiLan1.0
TLR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21121,637,696 - 21,650,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1921,630,343 - 21,652,922 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0988,827,495 - 88,840,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19117,180,250 - 117,193,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9117,180,550 - 117,190,711 (+)Ensemblpanpan1.1panPan2
TLR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11171,356,390 - 71,367,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1171,356,390 - 71,367,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1169,768,502 - 69,779,281 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01172,483,514 - 72,494,289 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1172,483,210 - 72,494,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11171,012,889 - 71,023,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01171,034,981 - 71,045,756 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01171,767,611 - 71,778,394 (+)NCBIUU_Cfam_GSD_1.0
Tlr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947186,750,688 - 186,763,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364876,518,441 - 6,533,095 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364876,519,140 - 6,532,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,044,610 - 258,058,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,044,610 - 258,054,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21289,775,816 - 289,785,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11221,873,762 - 21,885,562 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1221,871,773 - 21,885,515 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603521,002,852 - 21,019,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476017,598,630 - 17,609,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476017,596,516 - 17,608,955 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr4
528 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:769
Count of miRNA genes:531
Interacting mature miRNAs:615
Transcripts:ENSMUST00000048096, ENSMUST00000107365, ENSMUST00000143580, ENSMUST00000147008
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45010026284100408Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45010026284100408Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588510637Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
13524838Hbasrq1a_mhabituation of the acoustic startle response QTL 1a (mouse)45447158988471589Mouse
13524841Hbasrq1_mhabituation of the acoustic startle response QTL 1 (mouse)45447158988471589Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094788237Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
10043964Obq26_mobesity QTL 26 (mouse)Not determined45904725193047251Mouse
1357507Synch2_msynechia 2 (mouse)Not determined46014527794145424Mouse
1301190Cd4ts2_mCD4 T cell subset 2 (mouse)Not determined46014527794145424Mouse
1357443Lhyp_mlung hyperpermeability (mouse)Not determined46045401166764818Mouse
25394561Skmw53_mskeletal muscle weight 53, TA (mouse)46213829369838031Mouse
1357870Pfat1_mpredicted fat percentage 1 (mouse)Not determined46361952697619685Mouse
12879903Berr8_mberghei resistance locus 8 (mouse)46422246098222460Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
13506251Cytrq1_mcytokine response QTL 1 (mouse)46571808699718086Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12880404Embq1_memotional behavior QTL 1 (mouse)46575720395921546Mouse
27095938Ulnl6_mulna length 6, 10 week (mouse)46671823798588237Mouse
10450540Yprl2_mYersinia pestis resistance locus 2 (mouse)46674578866764818Mouse
1301757Tlsr4_mthymic lymphoma suppressor region 4 (mouse)Not determined466757130100757258Mouse

Markers in Region
AF095353  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38466,841,570 - 66,841,654UniSTSGRCm38
MGSCv37466,502,604 - 66,502,688UniSTSGRCm37
Celera465,444,900 - 65,444,984UniSTS
Cytogenetic Map4C1UniSTS
cM Map433.0UniSTS
Whitehead/MRC_RH41010.8UniSTS
UniSTS:234941  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38466,841,636 - 66,841,856UniSTSGRCm38
MGSCv37466,502,670 - 66,502,890UniSTSGRCm37
Celera465,444,966 - 65,445,186UniSTS
Cytogenetic Map4C1UniSTS
cM Map433.0UniSTS
PMC289161P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38466,841,119 - 66,841,421UniSTSGRCm38
MGSCv37466,502,153 - 66,502,455UniSTSGRCm37
Celera465,444,449 - 65,444,751UniSTS
Cytogenetic Map4C1UniSTS
cM Map433.0UniSTS
Tlr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38466,841,186 - 66,841,371UniSTSGRCm38
MGSCv37466,502,097 - 66,502,216UniSTSGRCm37
Celera465,444,516 - 65,444,701UniSTS
Cytogenetic Map4C1UniSTS
cM Map433.0UniSTS
cM Map433.0UniSTS
cM Map433.0UniSTS
Tlr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38466,841,063 - 66,841,182UniSTSGRCm38
MGSCv37466,502,097 - 66,502,216UniSTSGRCm37
Celera465,444,393 - 65,444,512UniSTS
Cytogenetic Map4C1UniSTS
cM Map433.0UniSTS
Tlr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C1UniSTS
cM Map433.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF095353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF110133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF185285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI450864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL805946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX514079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD544295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX878358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX878359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC811657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF696967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000048096   ⟹   ENSMUSP00000045770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl466,745,821 - 66,761,037 (+)Ensembl
GRCm38.p6 Ensembl466,827,584 - 66,842,800 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107365   ⟹   ENSMUSP00000102988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl466,745,850 - 66,848,521 (+)Ensembl
GRCm38.p6 Ensembl466,827,613 - 66,930,284 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl466,745,856 - 66,757,666 (+)Ensembl
GRCm38.p6 Ensembl466,827,619 - 66,839,429 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147008
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl466,746,439 - 66,757,855 (+)Ensembl
GRCm38.p6 Ensembl466,828,202 - 66,839,618 (+)Ensembl
RefSeq Acc Id: NM_021297   ⟹   NP_067272
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39466,745,788 - 66,764,818 (+)NCBI
GRCm38466,827,551 - 66,846,581 (+)NCBI
MGSCv37466,488,845 - 66,503,831 (+)RGD
Celera465,431,141 - 65,446,127 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036163964   ⟹   XP_036019857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39466,745,819 - 66,765,338 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_067272 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019857 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC99411 (Get FASTA)   NCBI Sequence Viewer  
  AAD29272 (Get FASTA)   NCBI Sequence Viewer  
  AAF04278 (Get FASTA)   NCBI Sequence Viewer  
  AAF05317 (Get FASTA)   NCBI Sequence Viewer  
  AAH29856 (Get FASTA)   NCBI Sequence Viewer  
  AGA16685 (Get FASTA)   NCBI Sequence Viewer  
  AGA16686 (Get FASTA)   NCBI Sequence Viewer  
  AGX25444 (Get FASTA)   NCBI Sequence Viewer  
  AGX25445 (Get FASTA)   NCBI Sequence Viewer  
  AGX25446 (Get FASTA)   NCBI Sequence Viewer  
  AGX25447 (Get FASTA)   NCBI Sequence Viewer  
  AGX25448 (Get FASTA)   NCBI Sequence Viewer  
  AGX25449 (Get FASTA)   NCBI Sequence Viewer  
  AGX25450 (Get FASTA)   NCBI Sequence Viewer  
  AGX25451 (Get FASTA)   NCBI Sequence Viewer  
  AGX25452 (Get FASTA)   NCBI Sequence Viewer  
  AGY29656 (Get FASTA)   NCBI Sequence Viewer  
  AGY29657 (Get FASTA)   NCBI Sequence Viewer  
  AGY29658 (Get FASTA)   NCBI Sequence Viewer  
  AGY29659 (Get FASTA)   NCBI Sequence Viewer  
  AGY29660 (Get FASTA)   NCBI Sequence Viewer  
  AGY29661 (Get FASTA)   NCBI Sequence Viewer  
  AGY29662 (Get FASTA)   NCBI Sequence Viewer  
  AGY29663 (Get FASTA)   NCBI Sequence Viewer  
  AGY29664 (Get FASTA)   NCBI Sequence Viewer  
  AGY29665 (Get FASTA)   NCBI Sequence Viewer  
  AGY29666 (Get FASTA)   NCBI Sequence Viewer  
  AGY29667 (Get FASTA)   NCBI Sequence Viewer  
  AGY29668 (Get FASTA)   NCBI Sequence Viewer  
  AGY29669 (Get FASTA)   NCBI Sequence Viewer  
  AGY29670 (Get FASTA)   NCBI Sequence Viewer  
  AGY29671 (Get FASTA)   NCBI Sequence Viewer  
  AGY29672 (Get FASTA)   NCBI Sequence Viewer  
  AGY29673 (Get FASTA)   NCBI Sequence Viewer  
  AGY29674 (Get FASTA)   NCBI Sequence Viewer  
  AGY29675 (Get FASTA)   NCBI Sequence Viewer  
  AGY29676 (Get FASTA)   NCBI Sequence Viewer  
  AGY29677 (Get FASTA)   NCBI Sequence Viewer  
  AGY29678 (Get FASTA)   NCBI Sequence Viewer  
  AGY29679 (Get FASTA)   NCBI Sequence Viewer  
  AGY29680 (Get FASTA)   NCBI Sequence Viewer  
  AGY29681 (Get FASTA)   NCBI Sequence Viewer  
  AGY29682 (Get FASTA)   NCBI Sequence Viewer  
  AGY29683 (Get FASTA)   NCBI Sequence Viewer  
  AGY29684 (Get FASTA)   NCBI Sequence Viewer  
  AGY29685 (Get FASTA)   NCBI Sequence Viewer  
  AGY29686 (Get FASTA)   NCBI Sequence Viewer  
  AGY29687 (Get FASTA)   NCBI Sequence Viewer  
  AGY29688 (Get FASTA)   NCBI Sequence Viewer  
  AGY29689 (Get FASTA)   NCBI Sequence Viewer  
  AGY29690 (Get FASTA)   NCBI Sequence Viewer  
  AGY29691 (Get FASTA)   NCBI Sequence Viewer  
  AGY29692 (Get FASTA)   NCBI Sequence Viewer  
  AGY29693 (Get FASTA)   NCBI Sequence Viewer  
  AGY29694 (Get FASTA)   NCBI Sequence Viewer  
  AGY29695 (Get FASTA)   NCBI Sequence Viewer  
  AGY29696 (Get FASTA)   NCBI Sequence Viewer  
  AGY29697 (Get FASTA)   NCBI Sequence Viewer  
  AGY29698 (Get FASTA)   NCBI Sequence Viewer  
  AGY29699 (Get FASTA)   NCBI Sequence Viewer  
  AGY29700 (Get FASTA)   NCBI Sequence Viewer  
  AGY29701 (Get FASTA)   NCBI Sequence Viewer  
  AGY29702 (Get FASTA)   NCBI Sequence Viewer  
  AGY29703 (Get FASTA)   NCBI Sequence Viewer  
  AGY29704 (Get FASTA)   NCBI Sequence Viewer  
  AGY29705 (Get FASTA)   NCBI Sequence Viewer  
  AGY29706 (Get FASTA)   NCBI Sequence Viewer  
  AGY29707 (Get FASTA)   NCBI Sequence Viewer  
  AGY29708 (Get FASTA)   NCBI Sequence Viewer  
  AGY29709 (Get FASTA)   NCBI Sequence Viewer  
  AGY29710 (Get FASTA)   NCBI Sequence Viewer  
  AGY29711 (Get FASTA)   NCBI Sequence Viewer  
  AGY29712 (Get FASTA)   NCBI Sequence Viewer  
  AGY29713 (Get FASTA)   NCBI Sequence Viewer  
  AGY29714 (Get FASTA)   NCBI Sequence Viewer  
  AGY29715 (Get FASTA)   NCBI Sequence Viewer  
  AGY29716 (Get FASTA)   NCBI Sequence Viewer  
  AGY29717 (Get FASTA)   NCBI Sequence Viewer  
  AGY29718 (Get FASTA)   NCBI Sequence Viewer  
  AGY29719 (Get FASTA)   NCBI Sequence Viewer  
  AGY29720 (Get FASTA)   NCBI Sequence Viewer  
  AGY29721 (Get FASTA)   NCBI Sequence Viewer  
  AGY29722 (Get FASTA)   NCBI Sequence Viewer  
  AGY29723 (Get FASTA)   NCBI Sequence Viewer  
  AGY29724 (Get FASTA)   NCBI Sequence Viewer  
  AGY29725 (Get FASTA)   NCBI Sequence Viewer  
  AGY29726 (Get FASTA)   NCBI Sequence Viewer  
  AGY29727 (Get FASTA)   NCBI Sequence Viewer  
  AGY29728 (Get FASTA)   NCBI Sequence Viewer  
  AGY29729 (Get FASTA)   NCBI Sequence Viewer  
  AGY29730 (Get FASTA)   NCBI Sequence Viewer  
  AGY29731 (Get FASTA)   NCBI Sequence Viewer  
  AGY29732 (Get FASTA)   NCBI Sequence Viewer  
  AGY29733 (Get FASTA)   NCBI Sequence Viewer  
  AGY29734 (Get FASTA)   NCBI Sequence Viewer  
  AGY29735 (Get FASTA)   NCBI Sequence Viewer  
  AGY29736 (Get FASTA)   NCBI Sequence Viewer  
  AGY29737 (Get FASTA)   NCBI Sequence Viewer  
  AGY29738 (Get FASTA)   NCBI Sequence Viewer  
  AGY29739 (Get FASTA)   NCBI Sequence Viewer  
  AGY29740 (Get FASTA)   NCBI Sequence Viewer  
  AGY29741 (Get FASTA)   NCBI Sequence Viewer  
  AGY29742 (Get FASTA)   NCBI Sequence Viewer  
  AGY29743 (Get FASTA)   NCBI Sequence Viewer  
  AGY29744 (Get FASTA)   NCBI Sequence Viewer  
  AGY29745 (Get FASTA)   NCBI Sequence Viewer  
  AGY29746 (Get FASTA)   NCBI Sequence Viewer  
  AGY29747 (Get FASTA)   NCBI Sequence Viewer  
  AGY29748 (Get FASTA)   NCBI Sequence Viewer  
  AGY29749 (Get FASTA)   NCBI Sequence Viewer  
  AGY29750 (Get FASTA)   NCBI Sequence Viewer  
  AGY29751 (Get FASTA)   NCBI Sequence Viewer  
  AGY29752 (Get FASTA)   NCBI Sequence Viewer  
  AGY29753 (Get FASTA)   NCBI Sequence Viewer  
  AGY29754 (Get FASTA)   NCBI Sequence Viewer  
  AGY29755 (Get FASTA)   NCBI Sequence Viewer  
  AGY29756 (Get FASTA)   NCBI Sequence Viewer  
  BAE32498 (Get FASTA)   NCBI Sequence Viewer  
  CAD83014 (Get FASTA)   NCBI Sequence Viewer  
  EDL31078 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000045770
  ENSMUSP00000045770.6
  ENSMUSP00000102988.3
GenBank Protein Q9QUK6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_067272   ⟸   NM_021297
- Peptide Label: precursor
- UniProtKB: Q9QZF5 (UniProtKB/Swiss-Prot),   Q9D691 (UniProtKB/Swiss-Prot),   Q9Z203 (UniProtKB/Swiss-Prot),   Q9QUK6 (UniProtKB/Swiss-Prot),   L0CL36 (UniProtKB/TrEMBL),   Q3U4D4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000102988   ⟸   ENSMUST00000107365
RefSeq Acc Id: ENSMUSP00000045770   ⟸   ENSMUST00000048096
RefSeq Acc Id: XP_036019857   ⟸   XM_036163964
- Peptide Label: isoform X1
- UniProtKB: V9PC11 (UniProtKB/TrEMBL)
Protein Domains
LRRCT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUK6-F1-model_v2 AlphaFold Q9QUK6 1-835 view protein structure

Promoters
RGD ID:6836519
Promoter ID:MM_KWN:38040
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000000668,   OTTMUST00000000669,   OTTMUST00000000670,   OTTMUST00000020618
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36466,488,456 - 66,488,956 (+)MPROMDB
RGD ID:6883678
Promoter ID:EPDNEW_M5290
Type:initiation region
Name:Tlr4_1
Description:Mus musculus toll-like receptor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5291  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38466,827,611 - 66,827,671EPDNEW
RGD ID:6883680
Promoter ID:EPDNEW_M5291
Type:initiation region
Name:Tlr4_2
Description:Mus musculus toll-like receptor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5290  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38466,827,781 - 66,827,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96824 AgrOrtholog
Ensembl Genes ENSMUSG00000039005 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048096 ENTREZGENE
  ENSMUST00000048096.12 UniProtKB/Swiss-Prot
  ENSMUST00000107365.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21898 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96824 ENTREZGENE
NCBI Gene 21898 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TLR4 RGD
PhenoGen Tlr4 PhenoGen
PIRSF Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2BHU8_MOUSE UniProtKB/TrEMBL
  L0CL36 ENTREZGENE, UniProtKB/TrEMBL
  L0CMZ8_MOUSE UniProtKB/TrEMBL
  Q3U4D4 ENTREZGENE, UniProtKB/TrEMBL
  Q8K2T5_MOUSE UniProtKB/TrEMBL
  Q9D691 ENTREZGENE
  Q9QUK6 ENTREZGENE
  Q9QZF5 ENTREZGENE
  Q9Z203 ENTREZGENE
  TLR4_MOUSE UniProtKB/Swiss-Prot
  U5LHT6_MOUSE UniProtKB/TrEMBL
  U5LIT9_MOUSE UniProtKB/TrEMBL
  U5LL15_MOUSE UniProtKB/TrEMBL
  U5LL67_MOUSE UniProtKB/TrEMBL
  V9PC11 ENTREZGENE
UniProt Secondary Q9D691 UniProtKB/Swiss-Prot
  Q9QZF5 UniProtKB/Swiss-Prot
  Q9Z203 UniProtKB/Swiss-Prot