Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FNDC3A mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of FNDC3A mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of FNDC3A mRNA | CTD | PMID:29097150 | 17beta-estradiol | increases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of FNDC3A mRNA | CTD | PMID:32145629 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of FNDC3A mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of FNDC3A mRNA | CTD | PMID:26251327 | 5-aza-2'-deoxycytidine | decreases methylation | EXP | | 6480464 | Decitabine results in decreased methylation of FNDC3A gene | CTD | PMID:27923600 | acetamide | decreases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of FNDC3A mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases methylation | ISO | FNDC3A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of FNDC3A gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | decreases methylation | ISO | FNDC3A (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of FNDC3A intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Tretinoin results in increased expression of FNDC3A mRNA | CTD | PMID:33167477 | aristolochic acid A | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of FNDC3A mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | Benzo(a)pyrene results in increased expression of FNDC3A mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases methylation | ISO | FNDC3A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of FNDC3A promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of FNDC3A mRNA | CTD | PMID:25047013 | bisphenol A | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of FNDC3A gene | CTD | PMID:31601247 | bisphenol A | affects methylation | ISO | FNDC3A (Homo sapiens) | 6480464 | bisphenol A affects the methylation of FNDC3A gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of FNDC3A mRNA | CTD | PMID:30816183 and PMID:34947998 | bisphenol A | increases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of FNDC3A mRNA | CTD | PMID:25181051 and PMID:32145629 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of FNDC3A mRNA | CTD | PMID:24982889 | caffeine | decreases phosphorylation | ISO | FNDC3A (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of FNDC3A protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to FNDC3A gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of FNDC3A mRNA | CTD | PMID:37019170 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of FNDC3A mRNA | CTD | PMID:19770486 | cyclosporin A | increases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of FNDC3A mRNA | CTD | PMID:20106945 more ... | dorsomorphin | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of FNDC3A mRNA | CTD | PMID:29803840 | entinostat | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | entinostat results in decreased expression of FNDC3A mRNA | CTD | PMID:27188386 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of FNDC3A mRNA | CTD | PMID:30319688 | flutamide | decreases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of FNDC3A mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of FNDC3A mRNA | CTD | PMID:21867686 | FR900359 | affects phosphorylation | ISO | FNDC3A (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of FNDC3A protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of FNDC3A gene | CTD | PMID:31601247 | hydrogen peroxide | affects expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of FNDC3A mRNA | CTD | PMID:20044591 | ivermectin | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of FNDC3A protein | CTD | PMID:32959892 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of FNDC3A mRNA | CTD | PMID:22609695 | menadione | affects expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of FNDC3A mRNA | CTD | PMID:20044591 | methapyrilene | decreases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of FNDC3A mRNA | CTD | PMID:30467583 | mitoxantrone | affects response to substance | ISO | FNDC3A (Homo sapiens) | 6480464 | FNDC3A protein affects the susceptibility to Mitoxantrone | CTD | PMID:16217747 | nickel sulfate | increases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | nickel sulfate results in increased expression of FNDC3A mRNA | CTD | PMID:11114790 | paracetamol | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of FNDC3A mRNA | CTD | PMID:21420995 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of FNDC3A mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of FNDC3A mRNA | CTD | PMID:27153767 | phenytoin | increases expression | ISO | Fndc3a (Rattus norvegicus) | 6480464 | Phenytoin results in increased expression of FNDC3A mRNA | CTD | PMID:20345932 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of FNDC3A mRNA | CTD | PMID:18445702 | potassium chromate | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of FNDC3A mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FNDC3A mRNA | CTD | PMID:22079256 | progesterone | increases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Progesterone results in increased expression of FNDC3A mRNA | CTD | PMID:18037150 | resveratrol | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of FNDC3A mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of FNDC3A mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of FNDC3A mRNA | CTD | PMID:28595984 and PMID:34032870 | sodium arsenite | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [FNDC3A protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | tacrolimus hydrate | increases expression | EXP | | 6480464 | Tacrolimus results in increased expression of FNDC3A mRNA | CTD | PMID:25270620 | testosterone | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Testosterone results in decreased expression of FNDC3A mRNA | CTD | PMID:33359661 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of FNDC3A mRNA | CTD | PMID:31919559 | trichostatin A | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of FNDC3A mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FNDC3A mRNA | CTD | PMID:27188386 | valproic acid | decreases methylation | ISO | FNDC3A (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of FNDC3A gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of FNDC3A mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | FNDC3A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of FNDC3A mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | FNDC3A (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FNDC3A mRNA | CTD | PMID:27188386 | vinclozolin | increases methylation | ISO | Fndc3a (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of FNDC3A gene | CTD | PMID:31079544 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 5. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:1759682 | PMID:2037301 | PMID:2045113 | PMID:2164218 | PMID:7558022 | PMID:8889548 | PMID:10087302 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:12477932 |
| PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:14621295 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:16904100 | PMID:17967808 | PMID:18799693 | PMID:21267068 | PMID:21873635 |
| PMID:24952961 | PMID:30787437 | PMID:32554809 | PMID:32591430 | PMID:38355793 |
Genomics
Comparative Map Data
| Fndc3a (Mus musculus - house mouse) |
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| FNDC3A (Homo sapiens - human) |
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| Fndc3a (Rattus norvegicus - Norway rat) |
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| Fndc3a (Chinchilla lanigera - long-tailed chinchilla) |
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| FNDC3A (Pan paniscus - bonobo/pygmy chimpanzee) |
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| FNDC3A (Canis lupus familiaris - dog) |
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| Fndc3a (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| FNDC3A (Sus scrofa - pig) |
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| FNDC3A (Chlorocebus sabaeus - green monkey) |
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| Fndc3a (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Fndc3a
5770 total Variants 
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