Ccl5 (C-C motif chemokine ligand 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ccl5 (C-C motif chemokine ligand 5) Mus musculus
Analyze
Symbol: Ccl5
Name: C-C motif chemokine ligand 5 (Ensembl:chemokine (C-C motif) ligand 5)
RGD ID: 69127
MGI Page MGI
Description: Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; lung; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C motif chemokine 5; chemokine (C-C motif) ligand 5; MuRa; MuRantes; RA; RANTES; S; Scy; Scya5; SIS-delta; SISd; small inducible cytokine A5; small-inducible cytokine A5; T-cell-specific protein RANTES; TCP22; TCP228
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 Ensembl
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
Acute Liver Failure  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (IEP)
Alzheimer's disease  (ISO)
Animal Toxoplasmosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
arteriosclerosis  (IEP,IMP,ISO)
asthma  (IEP,ISO)
atherosclerosis  (IMP)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (IDA)
bronchiolitis obliterans  (ISO)
bronchopneumonia  (ISO)
cardiac arrest  (ISO)
Chagas disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (IEP)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
exercise-induced bronchoconstriction  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,IGI,IMP,ISO)
Experimental Seizures  (ISO)
extrinsic allergic alveolitis  (IEP,ISO)
Fever  (ISO)
genetic disease  (ISO)
genital herpes  (IDA)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
hepatitis B  (IMP,ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (IMP,ISO)
Hermansky-Pudlak syndrome  (ISO)
Herpesviridae Infections  (IEP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IEP,IMP)
Hyperalgesia  (ISO)
Hyperoxaluria  (ISO)
hypertension  (ISO)
Hypoventilation  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (IEP,ISO)
interstitial lung disease  (IEP)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
liver cirrhosis  (IMP,ISO)
Liver Metastasis  (IMP)
Liver Reperfusion Injury  (IDA,IMP)
lung disease  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (IEP)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IMP)
non-alcoholic fatty liver  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
orchitis  (ISO)
Ovarian Neoplasms  (IMP)
Pain  (ISO)
pancreatic cancer  (IMP)
pancreatitis  (ISO)
Paramyxoviridae Infections  (ISO)
peptic esophagitis  (ISO)
pleurisy  (IEP)
Pneumococcal Pneumonia  (IMP)
posterior uveitis  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Pseudomonas Infections  (IEP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (IEP,ISO)
Respiration Disorders  (IEP)
respiratory syncytial virus infectious disease  (IEP)
sciatic neuropathy  (ISO)
scrapie  (IEP)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (HEP,IEP,ISO)
Spinal Cord Injuries  (IEP)
Spontaneous Abortions  (ISO)
steatotic liver disease  (IEP,ISO)
stomach cancer  (ISO)
Tissue Adhesions  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitroquinoline N-oxide  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (EXP)
8-chloro-2'-deoxyguanosine  (EXP)
9,10-anthraquinone  (ISO)
9-hydroxycanthin-6-one  (ISO)
acetamide  (ISO)
acrolein  (EXP)
adenine  (EXP)
albuterol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (ISO)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (ISO)
atropine  (EXP)
Bardoxolone methyl  (EXP)
beclomethasone  (ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-Funaltrexamine  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Brevianamide A  (EXP)
budesonide  (ISO)
butanal  (ISO)
butenafine  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carrageenan  (EXP,ISO)
catechol  (ISO)
celecoxib  (EXP)
cephaeline  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP)
chloroquine  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
chrysene  (EXP)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
cobalt atom  (EXP)
codeine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cytidine  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP,ISO)
dequalinium  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichloromethane  (ISO)
Didecyldimethylammonium  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diflorasone  (EXP)
digitoxigenin  (ISO)
digoxin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (EXP,ISO)
diuron  (ISO)
doxorubicin  (ISO)
emetine  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
Erionite  (EXP)
ethambutol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethyl acetate  (ISO)
Ethyl icosapentate  (EXP)
ethylbenzene  (ISO)
ethylene glycol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (ISO)
flavonoids  (ISO)
flunisolide  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formoterol fumarate  (ISO)
fragrance  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gemfibrozil  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine betaine  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
graphene oxide  (EXP)
GW 1929  (ISO)
helenalin  (ISO)
heparan sulfate  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hyaluronic acid  (EXP)
hydrazines  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (EXP)
kaempferol  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
lanatoside C  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(II) chloride  (ISO)
leukotriene B4  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
Luliconazole  (ISO)
LY294002  (EXP)
lycopene  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
maraviroc  (ISO)
masoprocol  (ISO)
mechlorethamine  (ISO)
meclocycline  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
metam  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methionine sulfoximine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
Methylbenzethonium chloride  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP,ISO)
minocycline  (ISO)
monocrotaline  (ISO)
monodansylcadaverine  (EXP)
morphine  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naringin  (ISO)
neocuproine  (EXP)
neoechinulin A  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
nicotine  (ISO)
nitric oxide  (EXP,ISO)
nitrogen dioxide  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
oxytetracycline  (ISO)
ozone  (EXP,ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (EXP)
PCB138  (ISO)
PD123319  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
pevonedistat  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phytoestrogen  (EXP)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (EXP,ISO)
prazosin  (ISO)
procyanidin B3  (EXP)
progesterone  (ISO)
propanal  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
prostaglandin E2  (EXP,ISO)
purine-6-thiol  (ISO)
pyocyanine  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rofecoxib  (EXP)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
salubrinal  (EXP)
SB 203580  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (EXP,ISO)
sulforaphane  (EXP)
sulindac  (ISO)
sunitinib  (EXP)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (EXP,ISO)
taurocholic acid  (EXP)
telmisartan  (ISO)
temozolomide  (ISO)
terameprocol  (EXP)
terbinafine  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (EXP)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (ISO)
trametinib  (EXP)
tremolite asbestos  (EXP)
triadimefon  (ISO)
triamcinolone acetonide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
verteporfin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
wortmannin  (EXP)
WR-1065  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
calcium ion transport  (ISO)
cell chemotaxis  (IBA)
cell-cell signaling  (ISO)
cellular response to alkyl hydroperoxide  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipid  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to morphine  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cellular response to vitamin K  (ISO)
chemokine-mediated signaling pathway  (IBA,ISO)
chemotaxis  (IEA)
chronic inflammatory response  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
eosinophil chemotaxis  (ISO)
epithelial cell proliferation  (IMP)
exocytosis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
immune response  (IEA)
inflammatory response  (IBA,IMP)
intracellular calcium ion homeostasis  (ISO)
leukocyte cell-cell adhesion  (ISO)
lymphocyte chemotaxis  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of macrophage apoptotic process  (IMP)
negative regulation of T cell apoptotic process  (ISO)
negative regulation of viral genome replication  (ISO)
neutrophil activation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IBA,ISO)
positive regulation of cell-cell adhesion mediated by integrin  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (NAS)
positive regulation of defense response to virus by host  (IC)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of fever generation  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of homotypic cell-cell adhesion  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of mast cell chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (IDA,ISO)
positive regulation of natural killer cell chemotaxis  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of T cell chemotaxis  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
pseudopodium assembly  (ISO)
regulation of insulin secretion  (ISO)
regulation of programmed cell death  (ISO)
regulation of T cell activation  (ISO)
response to activity  (ISO)
response to alcohol  (ISO)
response to bacterium  (ISO)
response to cholesterol  (ISO)
response to cytokine  (IDA,ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to salt stress  (ISO)
response to toxic substance  (ISO)
response to tumor necrosis factor  (IDA)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (ISO)
T-helper 1 cell diapedesis  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model. Akyildiz H, etal., Surgery. 2008 Sep;144(3):404-9. Epub 2008 Jul 10.
2. RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population. Al-Qahtani A, etal., Genet Mol Res. 2012 Apr 10;11(2):855-62. doi: 10.4238/2012.April.10.1.
3. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. Barnes DA, etal., J Clin Invest. 1998 Jun 15;101(12):2910-9.
4. A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer. Bauer L, etal., Ann Oncol. 2018 Jan 1;29(1):127-132. doi: 10.1093/annonc/mdx685.
5. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Baumer W, etal., Br J Dermatol. 2004 Oct;151(4):823-30.
6. Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats. Benamar K, etal., Eur J Pharmacol. 2008 Sep 11;592(1-3):93-5. Epub 2008 Jul 11.
7. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Berres ML, etal., J Clin Invest. 2010 Nov;120(11):4129-40. doi: 10.1172/JCI41732. Epub 2010 Oct 18.
8. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
9. Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. Bogdanski P, etal., Int J Clin Pharmacol Ther. 2007 Oct;45(10):563-7.
10. CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. Bonaros N, etal., J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53. Epub 2008 Jul 7.
11. [Urinary excretion of proinflammatory cytokines and transforming growth factor beta at early stages of diabetic nephropathy]. Bondar' IA, etal., Ter Arkh. 2008;80(1):52-6.
12. Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome. Borel JC, etal., PLoS One. 2009 Aug 24;4(8):e6733.
13. Macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis (MS) lesions. Boven LA, etal., Clin Exp Immunol. 2000 Nov;122(2):257-63.
14. The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. Brattstrom A, etal., Phytomedicine. 2010 Jul;17(8-9):551-6. Epub 2010 Jan 22.
15. Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis. Camelo S, etal., J Ocul Pharmacol Ther. 2009 Feb;25(1):9-21.
16. IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice. Carrigan SO, etal., J Immunol. 2010 Sep 15;185(6):3602-9. Epub 2010 Aug 18.
17. Expression and secretion of RANTES (CCL5) in granulomatous calcified tissue before and after lipopolysaccharide treatment in vivo. Castellani ML, etal., Calcif Tissue Int. 2007 Jan;80(1):60-7. Epub 2006 Dec 8.
18. The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy. Cavalher-Machado SC, etal., Int Immunopharmacol. 2008 Nov;8(11):1552-60. Epub 2008 Jul 29.
19. SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
20. Chemokine RANTES promoter dimorphisms and hepatocellular carcinoma occurrence in patients with alcoholic or hepatitis C virus-related cirrhosis. Charni F, etal., Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1439-46. doi: 10.1158/1055-9965.EPI-11-0341. Epub 2011 May 24.
21. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
22. Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. Chen Y, etal., Gut. 2004 Dec;53(12):1772-80.
23. Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury. Colombo G, etal., Shock. 2007 Mar;27(3):326-33.
24. Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD. Di Stefano A, etal., Thorax. 2009 Nov;64(11):968-75. Epub 2009 Aug 23.
25. Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease. Dodd J, etal., J Immunol. 2009 Jan 15;182(2):1174-81.
26. CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis--an intravital microscopy study. dos Santos AC, etal., J Neuroimmunol. 2005 May;162(1-2):122-9.
27. Microvascular Reactivity and Inflammatory Cytokines in Painful and Painless Peripheral Diabetic Neuropathy. Doupis J, etal., J Clin Endocrinol Metab. 2009 Mar 10.
28. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Duell EJ, etal., Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):726-31.
29. Local production of inflammatory mediators during childhood parainfluenza virus infection. El Feghaly RE, etal., Pediatr Infect Dis J. 2010 Apr;29(4):e26-31.
30. Dietary fatty acid unsaturation levels, lipoprotein oxidation and circulating chemokine in experimentally induced atherosclerotic rats. El Seweidy MM, etal., J Pharm Pharmacol. 2005 Nov;57(11):1467-74.
31. The role of the beta chemokines in experimental obliterative bronchiolitis. Farivar AS, etal., Exp Mol Pathol. 2003 Dec;75(3):210-6.
32. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26.
33. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
34. Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome. Goodwill AG, etal., Microcirculation. 2009 Nov;16(8):667-84.
35. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. Harandi AM, etal., J Virol. 2003 Jan;77(2):953-62.
36. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
37. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Herder C, etal., Diabetes. 2005 Dec;54 Suppl 2:S11-7.
38. Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat. Hofstetter C, etal., Crit Care Med. 2005 Oct;33(10):2317-22.
39. Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages. Hoshino Y, etal., J Immunol. 2004 May 15;172(10):6251-8.
40. Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways. Hou Y, etal., Acta Pharm Sin B. 2016 May;6(3):212-21. doi: 10.1016/j.apsb.2016.03.002. Epub 2016 Mar 22.
41. A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. Huik K, etal., PLoS One. 2016 Jun 15;11(6):e0156850. doi: 10.1371/journal.pone.0156850. eCollection 2016.
42. Optimal ratio of 18α- and 18β-glycyrrhizic acid for preventing alcoholic hepatitis in rats. Huo X, etal., Exp Ther Med. 2019 Jul;18(1):172-178. doi: 10.3892/etm.2019.7572. Epub 2019 May 10.
43. Quantitative expression levels of regulated on activation, normal T cell expressed and secreted and eotaxin transcripts in toluene diisocyanate-induced allergic rats. Im GJ, etal., Acta Otolaryngol. 2005 Apr;125(4):370-7.
44. Comparison of the acute effects of anti-TNF-alpha drugs on a uveitis experimental model. Johnsen-Soriano S, etal., Ocul Immunol Inflamm. 2010 Jun;18(3):208-15.
45. A model of chronic lung allograft rejection in the rat. Jungraithmayr W, etal., Eur Respir J. 2010 Jun;35(6):1354-63. Epub 2009 Oct 19.
46. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
47. Targeting of myelin protein zero in a spontaneous autoimmune polyneuropathy. Kim HJ, etal., J Immunol. 2008 Dec 15;181(12):8753-60.
48. Increased upper airway cytokines and oxidative stress in severe obstructive sleep apnoea. Kimoff RJ, etal., Eur Respir J. 2010 Sep 16.
49. Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice. Kizu T, etal., Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G613-24. doi: 10.1152/ajpgi.00289.2014. Epub 2015 Jan 23.
50. The effect of Toxoplasma gondii infection on expression of chemokines by rat retinal vascular endothelial cells. Knight BC, etal., J Neuroimmunol. 2005 Mar;160(1-2):41-7. Epub 2004 Dec 19.
51. Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Koenen RR, etal., Nat Med. 2009 Jan;15(1):97-103. doi: 10.1038/nm.1898. Epub 2009 Jan 4.
52. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. Lau YL and Peiris JS, Hong Kong Med J. 2009 Feb;15 Suppl 2:43-6.
53. C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury. Lee CM, etal., Sci Rep. 2017 Jun 16;7(1):3698. doi: 10.1038/s41598-017-03956-7.
54. Early up-regulation of chemokine expression in fulminant hepatic failure. Leifeld L, etal., J Pathol. 2003 Mar;199(3):335-44. doi: 10.1002/path.1298.
55. Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress. Li BH, etal., Transl Res. 2017 Feb;180:103-117.e4. doi: 10.1016/j.trsl.2016.08.006. Epub 2016 Aug 31.
56. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
57. The migration of T cells in response to influenza virus is altered in neonatal mice. Lines JL, etal., J Immunol. 2010 Sep 1;185(5):2980-8. Epub 2010 Jul 23.
58. Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. Louboutin JP, etal., FASEB J. 2010 Oct 12.
59. Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients. Maier R, etal., Mol Vis. 2008 Mar 27;14:637-43.
60. Serum inflammatory markers in diabetic retinopathy. Meleth AD, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4295-301.
61. MGDs mouse GO annotations MGD data from the GO Consortium
62. MGD IEA MGD IEA
63. Functional role of CCL5/RANTES for HCC progression during chronic liver disease. Mohs A, etal., J Hepatol. 2017 Apr;66(4):743-753. doi: 10.1016/j.jhep.2016.12.011. Epub 2016 Dec 21.
64. Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation. Mukaino M, etal., Exp Neurol. 2010 Aug;224(2):403-14. Epub 2010 May 16.
65. RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects. Nakajima K, etal., Diabetes Care. 2003 Mar;26(3):892-8.
66. High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors. Naura AS, etal., Lab Invest. 2009 Nov;89(11):1243-51. Epub 2009 Sep 14.
67. Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury. Nellen A, etal., PLoS One. 2012;7(5):e36614. doi: 10.1371/journal.pone.0036614. Epub 2012 May 4.
68. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. Nesbeth YC, etal., J Immunol. 2010 May 15;184(10):5654-62. Epub 2010 Apr 16.
69. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
70. Gammaherpesvirus modulation of mouse adenovirus type 1 pathogenesis. Nguyen Y, etal., Virology. 2008 Oct 25;380(2):182-90. Epub 2008 Sep 2.
71. Semiquantitative analysis of intrahepatic CC-chemokine mRNas in chronic hepatitis C. Nischalke HD, etal., Mediators Inflamm. 2004 Dec;13(5-6):357-9. doi: 10.1080/09629350400003159.
72. Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. Nomura S, etal., Thromb Res. 2005;115(4):277-85.
73. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. Oh SB, etal., J Neurosci. 2001 Jul 15;21(14):5027-35.
74. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
75. Expression of C-C chemokines in bronchoalveolar lavage cells from patients with granulomatous lung diseases. Oshima M, etal., Lung. 1999;177(4):229-40.
76. Mast-cell activation augments the late phase reaction in experimental immune-mediated blepharoconjunctivitis. Ozaki A, etal., Graefes Arch Clin Exp Ophthalmol. 2003 May;241(5):394-402. Epub 2003 Apr 4.
77. CCL5 modulates pneumococcal immunity and carriage. Palaniappan R, etal., J Immunol. 2006 Feb 15;176(4):2346-56.
78. Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration. Pan HC, etal., Neurochem Res. 2009 Jul;34(7):1304-16. Epub 2009 Jan 17.
79. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. Patsouras MD, etal., J Autoimmun. 2015 Dec;65:30-7. doi: 10.1016/j.jaut.2015.08.001. Epub 2015 Aug 15.
80. Platelet activation in chronic cocaine users: effect of short term abstinence. Pereira J, etal., Platelets. 2011;22(8):596-601. doi: 10.3109/09537104.2011.578181. Epub 2011 Aug 2.
81. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
82. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
83. Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Promrat K, etal., Gastroenterology. 2003 Feb;124(2):352-60. doi: 10.1053/gast.2003.50061.
84. Tyrosine phosphorylation of vitreous inflammatory and angiogenic peptides and proteins in diabetic retinopathy. Reverter JL, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1378-82. Epub 2008 Oct 31.
85. Mouse MP Annotation Import Pipeline RGD automated import pipeline
86. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
87. Role of CCL3/MIP-1alpha and CCL5/RANTES during acute Trypanosoma cruzi infection in rats. Roffe E, etal., Microbes Infect. 2010 Aug;12(8-9):669-76. Epub 2010 May 7.
88. Alveolar macrophage dysregulation in Hermansky-Pudlak syndrome type 1. Rouhani FN, etal., Am J Respir Crit Care Med. 2009 Dec 1;180(11):1114-21. Epub 2009 Sep 3.
89. Therapeutic Effects of Evasin-1, a Chemokine Binding Protein, in Bleomycin-Induced Pulmonary Fibrosis. Russo RC, etal., Am J Respir Cell Mol Biol. 2010 Sep 10.
90. Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis. Samuel I, etal., J Gastrointest Surg. 2006 Jul-Aug;10(7):950-9.
91. Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain. Sanchez-Castanon M, etal., Int J Tuberc Lung Dis. 2009 Apr;13(4):480-5.
92. The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Schafer A, etal., Br J Pharmacol. 2008 Jul;154(5):1047-54. Epub 2008 May 12.
93. Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. Schaier M, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F769-80. Epub 2009 Jun 17.
94. Inhibition of transforming growth factor-beta signalling attenuates interleukin (IL)-18 plus IL-2-induced interstitial lung disease in mice. Segawa S, etal., Clin Exp Immunol. 2010 Jun;160(3):394-402. Epub 2010 Jan 19.
95. Regulated upon activation, normal T-cell expressed and secreted chemokine and interleukin-6 in rheumatic pulmonary hypertension, targets for therapeutic decisions. Serag AR, etal., Eur J Cardiothorac Surg. 2010 Apr;37(4):853-8. Epub 2009 Nov 20.
96. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Sharma AK, etal., Respir Res. 2009 Jun 26;10:58.
97. Activated protein C modulates chemokine response and tissue injury in experimental sepsis. Sharma GR, etal., Adv Exp Med Biol. 2008;614:83-91.
98. Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions. Soria G, etal., Cytokine. 2008 Oct;44(1):191-200. Epub 2008 Sep 13.
99. CCR5 deficiency enhances hepatic innate immune cell recruitment and inflammation in a murine model of acute hepatitis B infection. Stevens KE, etal., Immunol Cell Biol. 2019 Mar;97(3):317-325. doi: 10.1111/imcb.12221. Epub 2019 Jan 24.
100. Inhibition of metastasis by inhibition of tumor-derived CCL5. Stormes KA, etal., Breast Cancer Res Treat. 2005 Jan;89(2):209-12. doi: 10.1007/s10549-004-5328-3.
101. Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Stowell NC, etal., Respir Res. 2009 Jun 1;10:43.
102. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. Sugawa T, etal., Gut. 2008 May;57(5):575-81. Epub 2008 Jan 25.
103. The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection. Tagliabue C, etal., J Infect Dis. 2008 Oct 15;198(8):1180-8.
104. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. Tan MC, etal., J Immunol. 2009 Feb 1;182(3):1746-55.
105. Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. Tang M, etal., J Cereb Blood Flow Metab. 2010 Jan;30(1):119-29. Epub 2009 Sep 16.
106. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
107. Differential sensitivities of pyrogenic chemokine fevers to CC chemokine receptor 5 antibodies. Tavares E and Minano FJ, Fundam Clin Pharmacol. 2004 Apr;18(2):163-9.
108. Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. Thio CL, etal., J Immunol. 2008 Dec 1;181(11):7944-7. doi: 10.4049/jimmunol.181.11.7944.
109. Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice. Thorne PS, etal., Am J Respir Crit Care Med. 2006 Apr 1;173(7):759-68. Epub 2005 Dec 30.
110. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Tian M, etal., Eur J Pediatr. 2009 Aug;168(8):963-7. Epub 2008 Nov 13.
111. Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. Tinsley JH, etal., Am J Hypertens. 2009 Oct;22(10):1107-14. Epub 2009 Jul 16.
112. NF-kappaB and chemokine-cytokine expression in renal tubulointerstitium in experimental hyperoxaluria. Role of the renin-angiotensin system. Toblli JE, etal., Urol Res. 2005 Nov;33(5):358-67. Epub 2005 Nov 13.
113. Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. Tribouillard-Tanvier D, etal., J Virol. 2012 Oct;86(19):10377-83. doi: 10.1128/JVI.01340-12. Epub 2012 Jul 11.
114. Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis. Trinh L, etal., Mol Vis. 2008;14:2428-34. Epub 2008 Dec 19.
115. RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role. Tripathy D, etal., Neurobiol Aging. 2010 Jan;31(1):8-16. Epub 2008 Apr 28.
116. CCL5-28, CCL5-403, and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinoma. Tsai HT, etal., Med Oncol. 2012 Dec;29(4):2771-9. doi: 10.1007/s12032-012-0189-9. Epub 2012 Feb 29.
117. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Tyner JW, etal., Nat Med. 2005 Nov;11(11):1180-7. Epub 2005 Oct 2.
118. Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis. Uller L, etal., Respir Res. 2010 May 9;11(1):54.
119. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Umezawa M, etal., Cytokine. 2008 Aug;43(2):105-9. Epub 2008 Jul 1.
120. Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice. Veillard NR, etal., Circ Res. 2004 Feb 6;94(2):253-61. Epub 2003 Dec 1.
121. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
122. Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis. Wang Y, etal., Br J Pharmacol. 2009 Jul;157(6):1004-13. Epub 2009 Jun 5.
123. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
124. Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
125. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Wasmuth HE, etal., Hepatology. 2004 Aug;40(2):327-34. doi: 10.1002/hep.20322.
126. [Changes of RANTES levels in livers of patients with chronic hepatitis B: the clinical significance and the possible mechanisms]. Wei XQ, etal., Zhonghua Gan Zang Bing Za Zhi. 2007 Aug;15(8):585-8.
127. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Weigt SS, etal., Am J Transplant. 2008 Jul;8(7):1512-22.
128. Concentration of chemokines in peripheral blood in first trimester of diabetic pregnancy. Wender-Ozegowska E, etal., Acta Obstet Gynecol Scand. 2008;87(1):14-9.
129. Chemokine decoy receptor d6 plays a negative role in human breast cancer. Wu FY, etal., Mol Cancer Res. 2008 Aug;6(8):1276-88.
130. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Wu H, etal., Kidney Int. 2005 Jun;67(6):2178-86.
131. Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. Xie M, etal., Chin Med J (Engl). 2008 Jan 5;121(1):73-7.
132. Genetic variants in chemokine CC subfamily genes influence hepatitis C virus viral clearance. Yao Y, etal., J Hum Genet. 2018 Jul;63(7):831-839. doi: 10.1038/s10038-018-0452-9. Epub 2018 Apr 27.
133. Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Yao Z, etal., Aging (Albany NY). 2020 May 2;12(9):7639-7651. doi: 10.18632/aging.103101. Epub 2020 May 2.
134. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
135. [Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China]. Zhang C, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Dec;33(12):1279-82.
136. RANTES gene polymorphisms and asthma risk: A meta-analysis. Zhang YG, etal., Arch Med Res. 2010 Jan;41(1):50-8.
137. [Association of RANTES gene promoter -28C/G polymorphism with respiratory syncytial virus bronchiolitis]. Zhao DY, etal., Zhonghua Er Ke Za Zhi. 2008 Feb;46(2):89-93.
138. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Zhernakova A, etal., Genes Immun. 2006 Oct;7(7):544-9. Epub 2006 Jul 20.
139. RANTES in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction. Zietkowski Z, etal., Respiration. 2010;80(6):463-71. Epub 2009 Dec 7.
140. [Detection of ICAM-1 and RANTES in infants with bronchiolitis]. Zou LP and Zhang SL, Zhongguo Dang Dai Er Ke Za Zhi. 2010 Mar;12(3):181-3.
Additional References at PubMed
PMID:1375672   PMID:1376260   PMID:2456327   PMID:7507961   PMID:7513046   PMID:7542490   PMID:7594543   PMID:7594550   PMID:8981365   PMID:9311871   PMID:9365123   PMID:9730682  
PMID:10235110   PMID:10349636   PMID:10438970   PMID:10594742   PMID:10790402   PMID:10995569   PMID:11000125   PMID:11042159   PMID:11076861   PMID:11466387   PMID:11744622   PMID:11801530  
PMID:11818130   PMID:11890717   PMID:11893739   PMID:11911480   PMID:11972057   PMID:11987989   PMID:12077225   PMID:12080938   PMID:12093895   PMID:12112372   PMID:12126650   PMID:12234959  
PMID:12477932   PMID:12850812   PMID:12928419   PMID:14687724   PMID:14761932   PMID:15034013   PMID:15240757   PMID:15271961   PMID:15381731   PMID:15489334   PMID:15546955   PMID:15557190  
PMID:15718270   PMID:15748167   PMID:15860458   PMID:15890969   PMID:15905535   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16707500   PMID:16807117   PMID:16849492   PMID:16873271  
PMID:16940143   PMID:16982880   PMID:16983723   PMID:17220320   PMID:17244892   PMID:17641009   PMID:17641205   PMID:17893273   PMID:17978871   PMID:18287559   PMID:18388327   PMID:18624307  
PMID:18635850   PMID:18700040   PMID:18815890   PMID:18986535   PMID:19006696   PMID:19121387   PMID:19236348   PMID:19421418   PMID:19427874   PMID:19524301   PMID:19665464   PMID:19779041  
PMID:19853894   PMID:19923453   PMID:20038813   PMID:20046229   PMID:20371596   PMID:20442771   PMID:20573836   PMID:20720435   PMID:20864798   PMID:20886281   PMID:21074454   PMID:21148126  
PMID:21267068   PMID:21293018   PMID:21302497   PMID:21335555   PMID:21454528   PMID:21565393   PMID:21680945   PMID:21715689   PMID:21814510   PMID:21873635   PMID:22088941   PMID:22156592  
PMID:22178100   PMID:22205974   PMID:22214846   PMID:22289892   PMID:22297845   PMID:22385043   PMID:22425022   PMID:22447977   PMID:22494696   PMID:22494919   PMID:22679098   PMID:22797700  
PMID:22960654   PMID:23112334   PMID:23132945   PMID:23266888   PMID:23288157   PMID:23460747   PMID:23498790   PMID:23553711   PMID:23620790   PMID:23696660   PMID:23722213   PMID:23751821  
PMID:23810773   PMID:23900076   PMID:23918941   PMID:23935096   PMID:24030499   PMID:24171667   PMID:24244314   PMID:24244375   PMID:24252748   PMID:24464131   PMID:24711619   PMID:24882804  
PMID:24938715   PMID:25049356   PMID:25093679   PMID:25098295   PMID:25158055   PMID:25340820   PMID:25495686   PMID:25582888   PMID:25595646   PMID:26089223   PMID:26246404   PMID:26249173  
PMID:26406376   PMID:26626357   PMID:26647394   PMID:26725683   PMID:26733422   PMID:26799785   PMID:26873938   PMID:27183626   PMID:27226559   PMID:27279133   PMID:27318131   PMID:27337700  
PMID:27365293   PMID:27576490   PMID:27608599   PMID:27640148   PMID:27660294   PMID:27689697   PMID:27863423   PMID:27898058   PMID:28054838   PMID:28096401   PMID:28132854   PMID:28381538  
PMID:28416485   PMID:28550204   PMID:28574501   PMID:28674178   PMID:28782174   PMID:28813662   PMID:29138800   PMID:29216863   PMID:29374556   PMID:29477204   PMID:29558694   PMID:29632086  
PMID:29666472   PMID:29798841   PMID:30037996   PMID:30146158   PMID:30369865   PMID:30447270   PMID:30630119   PMID:30728174   PMID:30760705   PMID:30928429   PMID:30990165   PMID:31481754  
PMID:31557402   PMID:31809737   PMID:31995405   PMID:32218434   PMID:32324594   PMID:32358581   PMID:32948687   PMID:33027922   PMID:33239787   PMID:33744909   PMID:33781821   PMID:33789177  
PMID:33978316   PMID:34297038   PMID:34315111   PMID:34758342   PMID:35029290   PMID:35175938   PMID:35288960   PMID:35986378   PMID:36414671   PMID:36430701   PMID:36670424   PMID:36713454  
PMID:36908122   PMID:36918921   PMID:36946983   PMID:37093429   PMID:37185840   PMID:37275883   PMID:37789765   PMID:37974301   PMID:38003358   PMID:38091827   PMID:38240165   PMID:38492218  


Genomics

Comparative Map Data
Ccl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 Ensembl
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
CCL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,871,491 - 35,880,793 (-)EnsemblGRCh38hg38GRCh38
GRCh371734,198,495 - 34,207,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBINCBI36Build 36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
T2T-CHM13v2.01736,819,399 - 36,828,268 (-)NCBIT2T-CHM13v2.0
Ccl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,820,330 - 68,824,906 (-)NCBIGRCr8
mRatBN7.21068,322,826 - 68,327,380 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Celera1067,264,203 - 67,268,742 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ccl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,293,399 - 10,301,143 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,293,758 - 10,301,118 (-)NCBIChiLan1.0ChiLan1.0
CCL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,596,811 - 28,605,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)Ensemblpanpan1.1panPan2
CCL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,817,409 - 37,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,817,305 - 37,823,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,039,892 - 37,046,335 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,627,353 - 38,633,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,627,249 - 38,633,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,410,157 - 37,416,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,695,725 - 37,702,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,783,127 - 37,789,578 (+)NCBIUU_Cfam_GSD_1.0
Ccl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,815,103 - 36,821,857 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490253,034 - 259,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936490253,279 - 259,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,648,598 - 39,659,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,652,731 - 39,659,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,218,074 - 41,228,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,334,078 - 3,341,614 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,334,136 - 3,342,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccl5
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:183
Interacting mature miRNAs:203
Transcripts:ENSMUST00000035938, ENSMUST00000125015
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse

Markers in Region
Ccl5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1147.4UniSTS
cM Map1147.4UniSTS
Ccl5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
Ccl5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1147.4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB051897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF128187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY722103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE333205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M77747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S37648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000035938   ⟹   ENSMUSP00000039600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)Ensembl
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,419,554 - 83,421,339 (-)Ensembl
GRCm38.p6 Ensembl1183,528,728 - 83,530,513 (-)Ensembl
RefSeq Acc Id: NM_013653   ⟹   NP_038681
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,416,604 - 83,421,344 (-)NCBI
GRCm381183,525,778 - 83,530,518 (-)ENTREZGENE
MGSCv371183,339,280 - 83,344,020 (-)RGD
Celera1193,127,305 - 93,132,049 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_038681   ⟸   NM_013653
- Peptide Label: precursor
- UniProtKB: P30882 (UniProtKB/Swiss-Prot),   Q5XZF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039600   ⟸   ENSMUST00000035938
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30882-F1-model_v2 AlphaFold P30882 1-91 view protein structure

Promoters
RGD ID:6820571
Promoter ID:MM_KWN:8899
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000001951,   OTTMUST00000001952
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361183,343,631 - 83,344,131 (-)MPROMDB
RGD ID:8675908
Promoter ID:EPDNEW_M15985
Type:initiation region
Name:Ccl5_1
Description:Mus musculus chemokine (C-C motif) ligand 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381183,530,518 - 83,530,578EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98262 AgrOrtholog
Ensembl Genes ENSMUSG00000035042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035938 ENTREZGENE
  ENSMUST00000035938.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20304 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98262 ENTREZGENE
NCBI Gene 20304 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccl5 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCL5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XZF2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Ccl5  C-C motif chemokine ligand 5  Ccl5  chemokine (C-C motif) ligand 5  Symbol and/or name change 5135510 APPROVED