Gene: Acvr1b (activin A receptor, type 1B)
Mus musculus
Symbol:
Acvr1b
Name:
activin A receptor, type 1B
Description:
ENCODES a protein that exhibits activin binding; protein serine/threonine kinase activity; activin receptor activity, type I (ortholog); INVOLVED IN activin receptor signaling pathway; embryo development; hair follicle development; PARTICIPATES IN activin signaling pathway; ASSOCIATED WITH abnormal cell differentiation; abnormal distal visceral endoderm morphology; abnormal embryonic epiblast morphology; ASSOCIATED WITH Myocardial Ischemia (ortholog); Pancreatic Neoplasms (ortholog); FOUND IN cell surface (ortholog); integral to plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; methotrexate
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
6820432J04; activin receptor type IB; activin receptor type-1B; activin receptor-like kinase 4; ActR-IB; ActRIB; Acvrlk4; ALK-4; Alk4; serine/threonine-protein kinase receptor R2; SKR2
Orthologs:
Homo sapiens : ACVR1B
(activin A receptor, type IB)
HGNC
Rattus norvegicus : Acvr1b
(activin A receptor, type IB)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 15 101,174,125 - 101,212,601 + NCBI Mouse cM Map 15 56.48 NCBI Mouse Celera Assembly 15 103,342,168 - 103,360,926 + NCBI Mouse Genome Assembly Build 37 15 101,004,556 - 101,043,032 + NCBI Mouse Genome Assembly Build 36.1 15 101,004,556 - 101,043,032 + NCBI Mouse Cytogenetic Map 15 F2 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol decreases expression ISO RGD:1349804 6480464 Ethinyl Estradiol results in decreased expression of ACVR1B mRNA CTD PMID:18936297 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACVR1B mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735207 6480464 Tetrachlorodibenzodioxin affects the expression of ACVR1B mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of ACVR1B gene CTD PMID:21212295 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ACVR1B mRNA CTD PMID:20188158 amiodarone increases expression ISO RGD:1349804 6480464 Amiodarone results in increased expression of ACVR1B mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:735207 6480464 Ammonium Chloride affects the expression of ACVR1B mRNA CTD PMID:16483693 cadmium dichloride increases methylation ISO RGD:735207 6480464 Cadmium Chloride results in increased methylation of ACVR1B promoter CTD PMID:22457795 methotrexate affects expression EXP 6480464 Methotrexate affects the expression of ACVR1B mRNA CTD PMID:18502557 nickel sulfate increases expression ISO RGD:1349804 6480464 nickel sulfate results in increased expression of ACVR1B mRNA CTD PMID:18651567 paracetamol decreases expression ISO RGD:1349804 6480464 Acetaminophen results in decreased expression of ACVR1B mRNA CTD PMID:21420995 tacrolimus hydrate multiple interactions ISO RGD:1349804 6480464 [Tacrolimus inhibits the reaction [FKBP1A protein binds to ACVR1B protein]] which results in decreased ubiquitination of ACVR1B protein; more ... CTD PMID:16720724
Biological Process
activin receptor signaling pathway ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 activin receptor signaling pathway IDA 2290270 MGI:MGI:3619747|PMID:16115198 MGI MGI:MGI:3619747 PMID:16115198 cell surface receptor signaling pathway TAS 2290270 MGI:MGI:1201715|PMID:9512518 MGI MGI:MGI:1201715 PMID:9512518 embryo development IMP MGI:MGI:1857710 2290270 MGI:MGI:1201715|PMID:9512518 MGI MGI:MGI:1201715 PMID:9512518 G1/S transition of mitotic cell cycle ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 hair follicle development IMP 2290270 MGI:MGI:3589310|PMID:16127153 MGI MGI:MGI:3589310 PMID:16127153 in utero embryonic development IMP MGI:MGI:1857710 2290270 MGI:MGI:3511374|PMID:15485907 MGI MGI:MGI:3511374 PMID:15485907 in utero embryonic development IMP MGI:MGI:1857710 2290270 MGI:MGI:3624594|PMID:16564040 MGI MGI:MGI:3624594 PMID:16564040 induction of apoptosis ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 mesoderm development ISA EMBL:X94119 2290270 MGI:MGI:85075|PMID:9012495 MGI MGI:MGI:85075 PMID:9012495 negative regulation of cell growth ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 nodal signaling pathway ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 peptidyl-threonine phosphorylation IDA 2290270 MGI:MGI:3813431|PMID:18039968 UniProtKB MGI:MGI:3813431 PMID:18039968 peptidyl-threonine phosphorylation ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 phosphorylation IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 positive regulation of activin receptor signaling pathway ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of erythrocyte differentiation ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of pathway-restricted SMAD protein phosphorylation ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of transcription from RNA polymerase II promoter ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of trophoblast cell migration ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein autophosphorylation ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein phosphorylation ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein phosphorylation TAS 2290270 MGI:MGI:1201715|PMID:9512518 GOC MGI:MGI:1201715 PMID:9512518 protein phosphorylation IEA InterPro:IPR000472 2290270 MGI:MGI:2152098 GOC MGI:MGI:2152098 protein phosphorylation ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of signal transduction IDA 2290270 MGI:MGI:3763867|PMID:17936261 MGI MGI:MGI:3763867 PMID:17936261 regulation of transcription, DNA-dependent ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 signal transduction ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 signal transduction by phosphorylation ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transmembrane receptor protein serine/threonine kinase signaling pathway TAS 2290270 MGI:MGI:1201715|PMID:9512518 GOC MGI:MGI:1201715 PMID:9512518 transmembrane receptor protein serine/threonine kinase signaling pathway IEA InterPro:IPR000472 2290270 MGI:MGI:2152098 GOC MGI:MGI:2152098
Cellular Component
cell surface ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 integral to membrane IEA UniProtKB-KW:KW-0812 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 integral to plasma membrane TAS 2290270 MGI:MGI:1201715|PMID:9512518 MGI MGI:MGI:1201715 PMID:9512518 integral to plasma membrane ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 membrane IEA InterPro:IPR000472|InterPro:IPR003605 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 membrane IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 plasma membrane IEA UniProtKB-KW:KW-1003 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Molecular Function
activin binding IPI UniProtKB:Q04998 2290270 MGI:MGI:75241|PMID:7577669 MGI MGI:MGI:75241 PMID:7577669 activin receptor activity, type I ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 activin receptor activity, type I ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 ATP binding ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 inhibin binding ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 kinase activity IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 protein binding IPI UniProtKB:O95551 2290270 MGI:MGI:3813431|PMID:18039968 UniProtKB MGI:MGI:3813431 PMID:18039968 protein kinase activity IEA InterPro:IPR000719 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 protein serine/threonine kinase activity IDA 2290270 MGI:MGI:3813431|PMID:18039968 UniProtKB MGI:MGI:3813431 PMID:18039968 protein serine/threonine kinase activity ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 receptor signaling protein serine/threonine kinase activity ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 SMAD binding ISO UniProtKB:P80202 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 SMAD binding ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transferase activity IEA UniProtKB-KW:KW-0808 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transferase activity, transferring phosphorus-containing groups IEA InterPro:IPR011009 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 transforming growth factor beta-activated receptor activity IEA InterPro:IPR000472 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 transmembrane receptor protein serine/threonine kinase activity TAS 2290270 MGI:MGI:1201715|PMID:9512518 MGI MGI:MGI:1201715 PMID:9512518 ubiquitin protein ligase binding ISO UniProtKB:P36896 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
1301918 Skull22_m skull morphology 22 (mouse) Not determined 15 85823545 103440060 Mouse 1357614 Bmca_m bile mucin accumulation (mouse) Not determined 15 85818436 103440060 Mouse 4140981 Mpvq1_m mean platelet volume locus 1 (mouse) Not determined 15 85818436 103440060 Mouse 4142083 Ignpq3_m IgA nephropathy QTL 3 (mouse) Not determined 15 81887016 103440060 Mouse 4141902 Cia37_m collagen induced arthritis 37 (mouse) Not determined 15 80817483 103440060 Mouse 1300974 Pgia9_m proteoglycan induced arthritis 9 (mouse) Not determined 15 80817483 103440060 Mouse 1357579 Dmyaq3_m darker modification of yellow agouti QTL 3 (mouse) Not determined 15 80772190 103440060 Mouse 1301284 Cosz3_m cocaine seizure 3 (mouse) Not determined 15 80246184 103440060 Mouse 1301185 Hdlq4_m HDL QTL 4 (mouse) Not determined 15 79095961 103440060 Mouse 1300851 Heal4_m wound healing/regeneration 4 (mouse) Not determined 15 77460142 103440060 Mouse 4141515 Blmpf4_m bleomycin-induced pulmonary fibrosis 4 (mouse) Not determined 15 76461597 103440060 Mouse 1558995 Tsiq3_m T-cell secretion of IL-4 QTL 3 (mouse) Not determined 15 73583806 103440060 Mouse 1357569 Fmgty13_m femur geometry 13 (mouse) Not determined 15 72887788 103440060 Mouse 1558785 Ablp_m absorbance of eye lens protein (mouse) Not determined 15 72887788 103440060 Mouse 4141363 Nhdlq9_m non-HDL QTL 9 (mouse) Not determined 15 72887788 103440060 Mouse 1301721 Lipq3_m lipoprotein QTL 3 (mouse) Not determined 15 70295500 103440060 Mouse 1300726 Pitm4_m prion incubation time 4 (mouse) Not determined 15 70295500 103440060 Mouse 1300648 Dbsty4_m diabesity 4 (mouse) Not determined 15 70295500 103440060 Mouse 1300627 Sluc26_m susceptibility to lung cancer 26 (mouse) Not determined 15 70291882 103440060 Mouse 1558848 Marq5_m methamphetamine response QTL 5 (mouse) Not determined 15 67545799 101545941 Mouse 4141921 Pstc3_m periosteal circumference 3 (mouse) Not determined 15 67216927 101217076 Mouse 4141870 Dbsq2_m diabetes susceptibility QTL 2 (mouse) Not determined 15 67216927 101217076 Mouse 1302074 Bmd4_m bone mineral density 4 (mouse) Not determined 15 56154867 103347903 Mouse