Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1343569 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNFRSF12A mRNA | CTD | PMID:22079256 | 1,3-dinitrobenzene | increases expression | ISO | RGD:631329 | 6480464 | 3-dinitrobenzene results in increased expression of TNFRSF12A mRNA | CTD | PMID:22841810 | 1-chloro-2,4-dinitrobenzene | increases expression | EXP | | 6480464 | Dinitrochlorobenzene results in increased expression of TNFRSF12A mRNA | CTD | PMID:19647056 | 17beta-estradiol | multiple interactions | ISO | RGD:1343569 | 6480464 | Estradiol inhibits the reaction [Etoposide results in increased expression of TNFRSF12A mRNA] | CTD | PMID:19426747 | 17beta-estradiol | increases expression | ISO | RGD:1343569 | 6480464 | Estradiol results in increased expression of TNFRSF12A mRNA | CTD | PMID:20106945 | 17beta-estradiol | decreases expression | ISO | RGD:1343569 | 6480464 | Estradiol results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19426747 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1343569 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNFRSF12A mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TNFRSF12A mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1343569 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNFRSF12A mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:631329 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNFRSF12A mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19465110 PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19933214 PMID:19465110 | 2,4-dinitrotoluene | affects expression | ISO | RGD:631329 | 6480464 | 2,4-dinitrotoluene affects the expression of TNFRSF12A mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | RGD:631329 | 6480464 | 2,6-dinitrotoluene affects the expression of TNFRSF12A mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | EXP | | 6480464 | n-butoxyethanol results in increased expression of TNFRSF12A mRNA | CTD | PMID:19812364 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of TNFRSF12A mRNA | CTD | PMID:18648102 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:1343569 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TNFRSF12A mRNA | CTD | PMID:22079614 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1343569 | 6480464 | [Tretinoin co-treated with zoledronic acid] results in increased expression of TNFRSF12A mRNA | CTD | PMID:20349282 | ammonium chloride | affects expression | ISO | RGD:631329 | 6480464 | Ammonium Chloride affects the expression of TNFRSF12A mRNA | CTD | PMID:16483693 | arachidonic acid | increases expression | ISO | RGD:1343569 | 6480464 | Arachidonic Acid results in increased expression of TNFRSF12A mRNA | CTD | PMID:16704987 | arsenite(3-) | increases expression | EXP | | 6480464 | arsenite results in increased expression of TNFRSF12A mRNA | CTD | PMID:18191166 | arsenite(3-) | increases expression | ISO | RGD:1343569 | 6480464 | arsenite results in increased expression of TNFRSF12A mRNA | CTD | PMID:18585952 | arsenite(3-) | multiple interactions | ISO | RGD:1343569 | 6480464 | XPA protein affects the reaction [arsenite results in increased expression of TNFRSF12A mRNA] | CTD | PMID:18585952 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of TNFRSF12A mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF12A mRNA | CTD | PMID:22228805 PMID:22610609 | benzo[a]pyrene | increases expression | ISO | RGD:1343569 | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF12A mRNA | CTD | PMID:21632981 PMID:22316170 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF12A mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:1343569 | 6480464 | Benzo(a)pyrene results in increased expression of TNFRSF12A mRNA | CTD | PMID:22316170 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19770486 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:631329 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TNFRSF12A promoter | CTD | PMID:23359474 | bisphenol A | multiple interactions | ISO | RGD:631329 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TNFRSF12A promoter | CTD | PMID:23359474 | cadmium atom | increases expression | ISO | RGD:1343569 | 6480464 | Cadmium results in increased expression of TNFRSF12A mRNA | CTD | PMID:22562489 | cadmium dichloride | decreases methylation | ISO | RGD:631329 | 6480464 | Cadmium Chloride results in decreased methylation of TNFRSF12A promoter | CTD | PMID:22457795 | cadmium dichloride | increases expression | ISO | RGD:631329 | 6480464 | Cadmium Chloride results in increased expression of TNFRSF12A mRNA | CTD | PMID:19010381 | cadmium dichloride | affects expression | ISO | RGD:631329 | 6480464 | Cadmium Chloride affects the expression of TNFRSF12A mRNA | CTD | PMID:22110744 | calcitriol | increases expression | ISO | RGD:1343569 | 6480464 | Calcitriol results in increased expression of TNFRSF12A mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:1343569 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of TNFRSF12A mRNA | CTD | PMID:21592394 | cefaloridine | increases expression | ISO | RGD:631329 | 6480464 | Cephaloridine results in increased expression of TNFRSF12A mRNA | CTD | PMID:18500788 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF12A mRNA | CTD | PMID:20938992 | ciglitazone | increases expression | ISO | RGD:631329 | 6480464 | ciglitazone results in increased expression of TNFRSF12A mRNA | CTD | PMID:22193206 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of TNFRSF12A mRNA | CTD | PMID:21151649 | clofibric acid | affects expression | ISO | RGD:631329 | 6480464 | Clofibric Acid affects the expression of TNFRSF12A mRNA | CTD | PMID:17602206 | cobalt dichloride | decreases expression | ISO | RGD:1343569 | 6480464 | cobaltous chloride results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19376846 | copper(2+) sulfate | increases expression | ISO | RGD:1343569 | 6480464 | Copper Sulfate results in increased expression of TNFRSF12A mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1343569 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | RGD:1343569 | 6480464 | Asbestos, Crocidolite results in increased expression of TNFRSF12A mRNA | CTD | PMID:18687144 | cyclosporin A | increases expression | ISO | RGD:1343569 | 6480464 | Cyclosporine results in increased expression of TNFRSF12A mRNA | CTD | PMID:20106945 | diarsenic trioxide | decreases expression | ISO | RGD:1343569 | 6480464 | arsenic trioxide results in decreased expression of TNFRSF12A mRNA | CTD | PMID:19128835 | diazoxide | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of TNFRSF12A mRNA | CTD | PMID:21335049 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of TNFRSF12A mRNA | CTD | PMID:21266533 | dibutyl phthalate | multiple interactions | ISO | RGD:631329 | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TNFRSF12A promoter | CTD | PMID:23359474 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of TNFRSF12A mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:631329 | 6480464 | Dibutyl Phthalate results in increased expression of TNFRSF12A mRNA | CTD | PMID:21266533 | dimethyl sulfoxide | increases expression | ISO | RGD:631329 | 6480464 | Dimethyl Sulfoxide results in increased expression of TNFRSF12A mRNA | CTD | PMID:22193206 | elemental selenium | increases expression | ISO | RGD:1343569 | 6480464 | Selenium results in increased expression of TNFRSF12A mRNA | CTD | PMID:19244175 | etoposide | multiple interactions | ISO | RGD:1343569 | 6480464 | Estradiol inhibits the reaction [Etoposide results in increased expression of TNFRSF12A mRNA] | CTD | PMID:19426747 | etoposide | increases expression | ISO | RGD:1343569 | 6480464 | Etoposide results in increased expression of TNFRSF12A mRNA | CTD | PMID:19426747 | folic acid | increases expression | EXP | | 6480464 | Folic Acid results in increased expression of TNFRSF12A mRNA; more ... | CTD | PMID:17003819 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF12A mRNA | CTD | PMID:20938992 | formaldehyde | increases expression | ISO | RGD:631329 | 6480464 | Formaldehyde results in increased expression of TNFRSF12A mRNA | CTD | PMID:20884683 PMID:18499655 | formaldehyde | increases expression | ISO | RGD:631329 | 6480464 | Formaldehyde results in increased expression of TNFRSF12A mRNA | CTD | PMID:18499655 PMID:20884683 | furan | increases methylation | ISO | RGD:631329 | 6480464 | furan results in increased methylation of TNFRSF12A gene | CTD | PMID:22079235 | genistein | decreases expression | ISO | RGD:1343569 | 6480464 | Genistein results in decreased expression of TNFRSF12A mRNA | CTD | PMID:16705744 | hydrogen peroxide | affects expression | ISO | RGD:1343569 | 6480464 | Hydrogen Peroxide affects the expression of TNFRSF12A mRNA | CTD | PMID:20044591 | indole-3-methanol | affects expression | ISO | RGD:631329 | 6480464 | indole-3-carbinol affects the expression of TNFRSF12A mRNA | CTD | PMID:21396975 | indole-3-methanol | multiple interactions | ISO | RGD:631329 | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TNFRSF12A mRNA | CTD | PMID:22129741 | isoprenaline | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of TNFRSF12A mRNA | CTD | PMID:21335049 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFRSF12A mRNA | CTD | PMID:20938992 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of TNFRSF12A mRNA | CTD | PMID:17467022 | mechlorethamine | decreases expression | EXP | | 6480464 | Mechlorethamine results in decreased expression of TNFRSF12A mRNA | CTD | PMID:17107856 | melamine | increases expression | ISO | RGD:631329 | 6480464 | melamine results in increased expression of TNFRSF12A | CTD | PMID:23052191 | menadione | affects expression | ISO | RGD:1343569 | 6480464 | Vitamin K 3 affects the expression of TNFRSF12A mRNA | CTD | PMID:20044591 | methylmercury(1+) | increases expression | ISO | RGD:631329 | 6480464 | methylmercury II results in increased expression of TNFRSF12A mRNA | CTD | PMID:17905399 | microcystin-LR | increases expression | EXP | | 6480464 | cyanoginosin LR results in increased expression of TNFRSF12A mRNA | CTD | PMID:17654400 | mono(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of TNFRSF12A mRNA | CTD | PMID:22401849 | N-methyl-N-nitrosurea | increases expression | ISO | RGD:631329 | 6480464 | Methylnitrosourea results in increased expression of TNFRSF12A mRNA | CTD | PMID:17412507 | N-nitrosodiethylamine | increases expression | ISO | RGD:1343569 | 6480464 | Diethylnitrosamine results in increased expression of TNFRSF12A mRNA | CTD | PMID:21527772 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:631329 | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TNFRSF12A mRNA | CTD | PMID:22129741 | N-nitrosodiethylamine | increases expression | ISO | RGD:631329 | 6480464 | Diethylnitrosamine results in increased expression of TNFRSF12A mRNA | CTD | PMID:19638242 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:631329 | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF12A mRNA | CTD | PMID:18164116 | naphthalene | increases expression | EXP | | 6480464 | naphthalene results in increased expression of TNFRSF12A mRNA | CTD | PMID:18978301 | nickel sulfate | increases expression | EXP | | 6480464 | nickel sulfate results in increased expression of TNFRSF12A mRNA | CTD | PMID:16100012 | ofloxacin | increases expression | ISO | RGD:631329 | 6480464 | Ofloxacin results in increased expression of TNFRSF12A mRNA | CTD | PMID:20688128 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of TNFRSF12A mRNA | CTD | PMID:17095637 PMID:19555225 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of TNFRSF12A mRNA | CTD | PMID:19555225 PMID:17095637 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of TNFRSF12A mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1343569 | 6480464 | Acetaminophen results in increased expression of TNFRSF12A mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of TNFRSF12A mRNA | CTD | PMID:18544908 | paracetamol | increases expression | ISO | RGD:631329 | 6480464 | Acetaminophen results in increased expression of TNFRSF12A mRNA | CTD | PMID:17202762 | phenobarbital | affects expression | ISO | RGD:1343569 | 6480464 | Phenobarbital affects the expression of TNFRSF12A mRNA | CTD | PMID:19159669 | phenylephrine | increases expression | ISO | RGD:631329 | 6480464 | Phenylephrine results in increased expression of TNFRSF12A mRNA | CTD | PMID:18158353 | phosgene | affects expression | EXP | | 6480464 | Phosgene affects the expression of TNFRSF12A mRNA | CTD | PMID:16300373 | quercetin | increases expression | ISO | RGD:1343569 | 6480464 | Quercetin results in increased expression of TNFRSF12A mRNA | CTD | PMID:21632981 | ranitidine | multiple interactions | ISO | RGD:631329 | 6480464 | Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF12A mRNA] | CTD | PMID:16415329 | selenium atom | increases expression | ISO | RGD:1343569 | 6480464 | Selenium results in increased expression of TNFRSF12A mRNA | CTD | PMID:19244175 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of TNFRSF12A mRNA | CTD | PMID:19073995 | sodium fluoride | increases expression | EXP | | 6480464 | Sodium Fluoride results in increased expression of TNFRSF12A mRNA | CTD | PMID:21340527 | testosterone | multiple interactions | ISO | RGD:1343569 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of TNFRSF12A mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | RGD:1343569 | 6480464 | Testosterone results in increased expression of TNFRSF12A mRNA | CTD | PMID:21592394 | testosterone | increases expression | EXP | | 6480464 | Testosterone results in increased expression of TNFRSF12A mRNA | CTD | PMID:20403060 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of TNFRSF12A mRNA; more ... | CTD | PMID:18038451 | tetrachloromethane | multiple interactions | EXP | | 6480464 | PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF12A mRNA] | CTD | PMID:18038451 PMID:18622026 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of TNFRSF12A mRNA | CTD | PMID:18038451 PMID:18622026 | tetrachloromethane | multiple interactions | EXP | | 6480464 | PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF12A protein]; more ... | CTD | PMID:18038451 | toluene 2,4-diisocyanate | increases expression | EXP | | 6480464 | Toluene 2,4-Diisocyanate results in increased expression of TNFRSF12A mRNA | CTD | PMID:19647056 | trichloroethene | increases expression | ISO | RGD:631329 | 6480464 | Trichloroethylene results in increased expression of TNFRSF12A mRNA | CTD | PMID:17905399 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of TNFRSF12A mRNA | CTD | PMID:17963808 | vancomycin | decreases expression | EXP | | 6480464 | Vancomycin results in decreased expression of TNFRSF12A mRNA | CTD | PMID:18930951 | zinc atom | multiple interactions | ISO | RGD:1343569 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF12A mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1343569 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF12A mRNA | CTD | PMID:18593933 | zoledronic acid | multiple interactions | ISO | RGD:1343569 | 6480464 | [Tretinoin co-treated with zoledronic acid] results in increased expression of TNFRSF12A mRNA | CTD | PMID:20349282 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process








