Gene: Fbxw7 (F-box and WD-40 domain protein 7)
Mus musculus
Symbol:
Fbxw7
Name:
F-box and WD-40 domain protein 7
Description:
ENCODES a protein that exhibits sequence-specific DNA binding transcription factor activity; INVOLVED IN lung development; Notch signaling pathway; regulation of transcription, DNA-dependent; PARTICIPATES IN Notch signaling pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal blood vessel morphology; abnormal brain development; abnormal brain vasculature morphology; FOUND IN endoplasmic reticulum; Golgi apparatus; nucleus; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1110001A17Rik; AGO; Cdc4; F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; OTTMUSP00000025916; OTTMUSP00000025917; OTTMUSP00000025918; OTTMUSP00000025919; SEL-10
Orthologs:
Homo sapiens : FBXW7
(F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase)
HGNC
Rattus norvegicus : Fbxw7
(F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 84,815,577 - 84,979,198 + NCBI Mouse cM Map 3 37.7 NCBI Mouse Celera Assembly 3 84,827,347 - 84,997,996 + NCBI Mouse Genome Assembly Build 37 3 84,619,499 - 84,783,120 + NCBI Mouse Genome Assembly Build 36.1 3 84,756,133 - 84,781,556 + NCBI Mouse Cytogenetic Map 3 E3.3 NCBI
Model
Gene Ontology Annotations
Biological Process
cellular response to UV ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 lung development IMP MGI:MGI:5007620 2290270 MGI:MGI:5005005|PMID:21503901 MGI MGI:MGI:5005005 PMID:21503901 negative regulation of DNA endoreduplication ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Notch signaling pathway IDA 2290270 MGI:MGI:2150244|PMID:11425854 MGI MGI:MGI:2150244 PMID:11425854 positive regulation of epidermal growth factor-activated receptor activity ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of ERK1 and ERK2 cascade ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein stabilization ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein ubiquitination ISA UniProtKB:Q969H0 2290270 MGI:MGI:2386816|PMID:12354302 MGI MGI:MGI:2386816 PMID:12354302 protein ubiquitination ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transcription, DNA-dependent IDA 2290270 MGI:MGI:2150244|PMID:11425854 GOC MGI:MGI:2150244 PMID:11425854 response to DNA damage stimulus ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sister chromatid cohesion ISO UniProtKB:Q969H0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 vasculogenesis IMP 2290270 MGI:MGI:5005005|PMID:21503901 MGI MGI:MGI:5005005 PMID:21503901
1301272 Cfsw1_m cystic fibrosis survival to weaning 1 (mouse) Not determined 3 83779519 117779651 Mouse 1301388 Hdlq21_m HDL QTL 21 (mouse) Not determined 3 83360598 117360744 Mouse 1300752 Ap6q_m alcohol preference 6 QTL (mouse) Not determined 3 83360598 117360744 Mouse 1302181 Lvic2_m liver iron content 2 (mouse) Not determined 3 83269519 117269667 Mouse 1301862 Tchol1_m total cholesterol level 1 (mouse) Not determined 3 83269519 117269667 Mouse 1301904 Iba2_m induction of brown adipocytes 2 (mouse) Not determined 3 82043650 116043791 Mouse 1301947 Pcfm3_m periosteal circumference and femur length 3 (mouse) Not determined 3 80981259 114981404 Mouse 1301277 nctm1_m Nakano cataract modifier 1 (mouse) Not determined 3 80083059 114083208 Mouse 1357629 Ssta5_m susceptibility to Salmonella typhimurium antigens 5 (mouse) Not determined 3 79885628 113885768 Mouse 4142423 Prtia1_m pristane induced arthritis 1 (mouse) Not determined 3 79885628 113885768 Mouse 1301392 Eae3_m susceptibility to experimental allergic encephalomyelitis 3 (mouse) Not determined 3 79445337 113445444 Mouse 1300595 Tmevd2_m Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse) Not determined 3 75359917 109360164 Mouse 1301422 Sle11_m systematic lupus erythematosus susceptibility 11 (mouse) Not determined 3 70105519 104105657 Mouse 1357796 Trmq5_m T cell ratio modifier QTL 5 (mouse) Not determined 3 70067069 104067190 Mouse 4142498 Hctq1_m hematocrit QTL 1 (mouse) Not determined 3 68985423 102985534 Mouse 4141669 Vmmt18_m vertebral morphology and mechanical traits 18 (mouse) Not determined 3 68203118 102203263 Mouse 1301971 Cia5_m collagen induced arthritis QTL 5 (mouse) Not determined 3 65943273 99943410 Mouse 1558843 Ecla_m epistatic circling A C57L/J 1 (mouse) Not determined 3 65366294 99366439 Mouse 1301705 Sles3_m systemic lupus erythmatosus suppressor 3 (mouse) Not determined 3 61636676 95636856 Mouse 4141294 Bmd24_m bone mineral density 24 (mouse) Not determined 3 61636676 95636856 Mouse 1301398 Rapop3_m radiation-induced apoptosis 3 (mouse) Not determined 3 59902079 93902202 Mouse 1357585 Manln3_m mandible length 3 (mouse) Not determined 3 52522098 86522334 Mouse 1301917 Tshp4_m tooth shape 4 (mouse) Not determined 3 52522098 86522334 Mouse 1300593 Skull4_m skull morphology 4 (mouse) Not determined 3 52522098 86522334 Mouse 1301442 Pltpq1_m phospholipid transfer protein activity QTL 1 (mouse) Not determined 3 52522098 86522334 Mouse