Gene: Lep (leptin)  Mus musculus Symbol: Lep Name: leptin Description: ENCODES a protein that exhibits growth factor activity; hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN adipose tissue development; adult feeding behavior; bile acid metabolic process; PARTICIPATES IN hypoxia inducible factor pathway; energy homeostasis pathway; Jak-Stat signaling pathway; ASSOCIATED WITH abnormal acute inflammation; abnormal adipocyte glucose uptake; abnormal adipose tissue amount; ASSOCIATED WITH Diabetes Mellitus, Experimental; Diabetic Nephropathies; Heart Failure; FOUND IN extracellular space; INTERACTS WITH (R)-lipoic acid; (R)-mevalonic acid; 17beta-estradiol Type: protein-coding RefSeq Status: VALIDATED Also known as: leptin; ob; obese; obesity factor; OTTMUSP00000050551 Orthologs: Homo sapiens : LEP (leptin)  HGNC Rattus norvegicus : Lep (leptin) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,060,221 - 29,073,876 + NCBI Mouse cM Map 6 12.3   NCBI Mouse Celera Assembly 6 29,063,769 - 29,077,429 + NCBI Mouse Genome Assembly Build 37 6 29,010,221 - 29,023,876 + NCBI Mouse Genome Assembly Build 36.1 6 29,010,221 - 29,023,876 + NCBI Mouse Cytogenetic Map 6 A3.3   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Asthma   ISS RGD:69123 5128781 protein:increased expression:plasma RGD   Body Weight Changes   ISS RGD:3000 5128513   RGD   Brain Injuries   ISS RGD:3000 5128517   RGD   Carcinoma, Non-Small-Cell Lung   ISS RGD:69123 5128815 protein:increased expression:serum RGD   Carcinoma, Renal Cell Resistance ISS RGD:69123 6907119   RGD   Cystic Fibrosis Severity ISS RGD:3000 5128819   RGD   Diabetes Mellitus, Experimental   ISS RGD:3000 2311124   RGD   Diabetes Mellitus, Experimental Onset ISS RGD:3000 5128579   RGD   Diabetes Mellitus, Experimental   IPM   2311126   RGD   Diabetes Mellitus, Type 2   ISS RGD:3000 2311130   RGD   Diabetes, Gestational   ISS RGD:69123 2311131 protein:increased expression:serum RGD   Diabetic Nephropathies   IAGP   6907074   RGD   Fatty Liver   ISS RGD:69123 2311137 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD   Femoral Fractures   ISS RGD:3000 5128517   RGD   Fetal Growth Retardation   ISS RGD:3000 5128507   RGD   Heart Failure   IPM   5128823   RGD   Huntington Disease   ISS RGD:3000 5128676 protein:decreased expression:serum RGD   Hypercapnia   ISS RGD:69123 5128875 associated with obesity RGD   Hypertension   ISS RGD:3000 5128597   RGD   Hypertension   ISS RGD:69123 5128788 DNA:SNPs: : RGD   Hypoventilation   ISS RGD:69123 5128870 Obesity Hypoventilation Syndrome RGD   Insulin Resistance   ISS RGD:69123 2311127 associated with Obesity RGD   Insulin Resistance   ISS RGD:3000 5128697 protein:increased expression:plasma RGD   Kidney Reperfusion Injury Resistance ISS RGD:3000 6909133   RGD   Liver Cirrhosis, Experimental   ISS RGD:3000 5128589   RGD   Liver Cirrhosis, Experimental Disease_progression IPM   5128713   RGD   Lung Diseases   IED   5128844 acute lung injury associated pancreatitis RGD   Metabolic Syndrome X   ISS RGD:69123 2311125   RGD   Myocardial Reperfusion Injury   ISS RGD:3000 5128547   RGD   Obesity   ISS RGD:3000 5128551 protein:increased expression:serum RGD   Obesity   ISS RGD:69123 7240710   OMIM   Obesity   IPM   2311134   RGD   Obesity   ISS RGD:69123 2311132 protein:increased expression:serum RGD   Obesity No_Association ISS RGD:69123 1643130   RGD   Obesity   ISS RGD:3000 5128629   RGD   Osteoporosis   ISS RGD:69123 5128771 associated with chronic obstructive pulmonary disease; more ... RGD   Pneumonia, Bacterial   IPM   5128871   RGD   Pneumonia, Pneumococcal   IPM   5128869   RGD   Pre-Eclampsia   ISS RGD:3000 5128718 protein:decreased expression:plasma RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:69123 5128772 protein:increased expression:plasma RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:69123 5128778 protein:decreased expression:serum RGD   Pulmonary Disease, Chronic Obstructive Severity ISS RGD:69123 5128777 DNA:polymorphism:promoter: -2548 G>A (human) RGD   Reperfusion Injury   ISS RGD:3000 5128549   RGD   Rhinitis   ISS RGD:69123 5128850   RGD   Sepsis   ISS RGD:3000 5128818   RGD   Short Bowel Syndrome   ISS RGD:3000 5128624   RGD   Sleep Apnea, Obstructive   ISS RGD:69123 5128817 protein:increased expression:plasma RGD   Spinal Cord Injuries   ISS RGD:3000 5128780   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-lipoic acid decreases secretion EXP   6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 (R)-lipoic acid decreases expression ISO RGD:3000 6480464 Thioctic Acid results in decreased expression of LEP mRNA; more ... CTD PMID:21351249 (R)-lipoic acid decreases expression EXP   6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 (R)-mevalonic acid multiple interactions EXP   6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; more ... CTD PMID:19254925 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:18359623 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:69123 6480464 Dihydrotestosterone results in decreased expression of LEP mRNA CTD PMID:18801408 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]; more ... CTD PMID:19063610 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of LEP mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:3000 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA; more ... CTD PMID:15977195 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA CTD PMID:19063610 2,6-di-tert-butyl-4-methylphenol multiple interactions EXP   6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP   6480464 Galactosamine promotes the reaction [LEP gene mutant form results in increased expression of SPP1 mRNA]; more ... CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose increases response to substance EXP   6480464 LEP gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 2-deoxy-D-glucose multiple interactions ISO RGD:3000 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 2-deoxy-D-glucose decreases secretion ISO RGD:3000 6480464 Deoxyglucose results in decreased secretion of LEP protein CTD PMID:10780946 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions EXP   6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; more ... CTD PMID:19254925 3',5'-cyclic AMP increases abundance ISO RGD:69123 6480464 LEP protein results in increased abundance of Cyclic AMP CTD PMID:11342529 3,4-methylenedioxymethamphetamine affects expression ISO RGD:3000 6480464 N-Methyl-3,4-methylenedioxyamphetamine affects the expression of LEP protein CTD PMID:17910739 3-chloropropane-1,2-diol decreases expression ISO RGD:3000 6480464 alpha-Chlorohydrin results in decreased expression of LEP mRNA CTD PMID:20409345 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LEP mRNA CTD PMID:19186324 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:69123 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 4-hydroxybenzoic acid decreases expression ISO RGD:69123 6480464 4-hydroxybenzoic acid results in decreased expression of LEP mRNA CTD PMID:22956630 5-aza-2'-deoxycytidine decreases methylation ISO RGD:69123 6480464 decitabine results in decreased methylation of LEP promoter CTD PMID:17502362 5-aza-2'-deoxycytidine multiple interactions ISO RGD:69123 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 5-aza-2'-deoxycytidine increases expression ISO RGD:69123 6480464 [decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA CTD PMID:17502362 9-cis-retinoic acid multiple interactions ISO RGD:3000 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 AACOCF3 multiple interactions EXP   6480464 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 acarbose decreases expression ISO RGD:3000 6480464 Acarbose results in decreased expression of LEP protein CTD PMID:18290871 acetaldehyde multiple interactions EXP   6480464 Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein]; more ... CTD PMID:17949463 acetaldehyde multiple interactions EXP   6480464 LEP protein affects the reaction [Acetaldehyde results in increased expression of TGFB1 protein]; more ... CTD PMID:15130784 acetylsalicylic acid multiple interactions ISO RGD:3000 6480464 [lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein CTD PMID:15024038 actinomycin D multiple interactions ISO RGD:3000 6480464 Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 aldehydo-D-glucosamine 6-phosphate decreases expression EXP   6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 all-trans-retinol multiple interactions ISO RGD:3000 6480464 LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 amlodipine decreases expression ISO RGD:69123 6480464 Amlodipine results in decreased expression of LEP CTD PMID:19059660 amlodipine decreases expression ISO RGD:69123 6480464 Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 ammonium chloride affects expression ISO RGD:3000 6480464 Ammonium Chloride affects the expression of LEP mRNA CTD PMID:16483693 anandamide decreases abundance ISO RGD:69123 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:16154199 anandamide decreases activity ISO RGD:69123 6480464 LEP protein results in decreased activity of anandamide CTD PMID:16154199 anandamide decreases transport ISO RGD:69123 6480464 LEP protein results in decreased transport of anandamide CTD PMID:16154199 apigenin increases expression EXP   6480464 Apigenin results in increased expression of LEP mRNA; more ... CTD PMID:18359623 apocynin multiple interactions EXP   6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; more ... CTD PMID:16380530 arachidonic acid multiple interactions EXP   6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 arsenic atom affects expression ISO RGD:69123 6480464 Arsenic affects the expression of LEP CTD PMID:20940111 aspartame decreases expression ISO RGD:3000 6480464 Aspartame results in decreased expression of LEP protein CTD PMID:11890951 ATP multiple interactions ISO RGD:3000 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein; more ... CTD PMID:10780946 bezafibrate decreases expression ISO RGD:69123 6480464 Bezafibrate results in decreased expression of LEP CTD PMID:10726910 bezafibrate decreases expression ISO RGD:3000 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11473052 PMID:11216866 bezafibrate decreases expression ISO RGD:3000 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11216866 PMID:11473052 bezafibrate decreases expression EXP   6480464 Bezafibrate results in decreased expression of LEP protein CTD PMID:21549692 bezafibrate multiple interactions ISO RGD:3000 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] CTD PMID:17379010 bis(2-ethylhexyl) phthalate increases expression EXP   6480464 Diethylhexyl Phthalate results in increased expression of LEP mRNA; more ... CTD PMID:22588786 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of LEP mRNA CTD PMID:18417718 PMID:18359623 bisphenol A multiple interactions EXP   6480464 bisphenol A promotes the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of LEP mRNA CTD PMID:18359623 PMID:18417718 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of LEP CTD PMID:20488778 bucladesine decreases expression EXP   6480464 Bucladesine results in decreased expression of LEP mRNA CTD PMID:9002984 calcitriol decreases abundance EXP   6480464 LEP protein results in decreased abundance of Calcitriol CTD PMID:14657008 calcium atom multiple interactions EXP   6480464 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium]; more ... CTD PMID:20107083 calcium atom multiple interactions ISO RGD:3000 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium atom affects secretion ISO RGD:3000 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium atom affects expression ISO RGD:3000 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium atom decreases abundance EXP   6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium atom affects abundance EXP   6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium atom multiple interactions EXP   6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]; more ... CTD PMID:16380530 calcium atom increases transport EXP   6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 calcium(0) multiple interactions EXP   6480464 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium]; more ... CTD PMID:20107083 calcium(0) multiple interactions ISO RGD:3000 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 calcium(0) affects secretion ISO RGD:3000 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 calcium(0) affects expression ISO RGD:3000 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 calcium(0) decreases abundance EXP   6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 calcium(0) affects abundance EXP   6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 calcium(0) multiple interactions EXP   6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]; more ... CTD PMID:16380530 calcium(0) increases transport EXP   6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 candesartan multiple interactions ISO RGD:69123 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP]; more ... CTD PMID:17483542 candesartan increases response to substance ISO RGD:3000 6480464 LEP protein results in increased susceptibility to candesartan CTD PMID:21287150 candesartan decreases expression ISO RGD:69123 6480464 candesartan results in decreased expression of LEP CTD PMID:19059660 capsaicin decreases expression EXP   6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 PMID:19798065 capsaicin decreases expression EXP   6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:19798065 PMID:17295509 capsaicin decreases expression EXP   6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 capsaicin multiple interactions ISO RGD:3000 6480464 Capsaicin inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA] CTD PMID:20359164 capsaicin multiple interactions ISO RGD:3000 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; more ... CTD PMID:22150557 capsaicin increases expression ISO RGD:3000 6480464 Capsaicin results in increased expression of LEP protein CTD PMID:22150557 capsaicin increases expression ISO RGD:3000 6480464 Capsaicin results in increased expression of LEP mRNA CTD PMID:16278290 CCCP decreases response to substance ISO RGD:69123 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein CTD PMID:11342529 CCCP multiple interactions ISO RGD:69123 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 cerulenin affects response to substance EXP   6480464 LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 chlorpromazine increases expression ISO RGD:3000 6480464 Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 chromium atom decreases expression ISO RGD:3000 6480464 Chromium results in decreased expression of LEP protein CTD PMID:17114815 clofibrate multiple interactions EXP   6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA; more ... CTD PMID:17585979 clofibrate multiple interactions ISO RGD:3000 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 clozapine affects response to substance ISO RGD:69123 6480464 LEP protein affects the susceptibility to Clozapine CTD PMID:17502770 clozapine increases expression ISO RGD:3000 6480464 Clozapine results in increased expression of LEP protein CTD PMID:16402076 cobalt dichloride increases expression ISO RGD:69123 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride increases expression ISO RGD:3000 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 cobalt dichloride increases secretion ISO RGD:3000 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion ISO RGD:69123 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 cobalt dichloride increases secretion EXP   6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:22019852 D-glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP protein CTD PMID:18627777 D-glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP mRNA CTD PMID:10780946 D-glucose increases secretion ISO RGD:3000 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 D-glucose multiple interactions ISO RGD:3000 6480464 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; more ... CTD PMID:10780946 D-glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 D-glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]; more ... CTD PMID:11342529 D-glucose multiple interactions ISO RGD:3000 6480464 LEP promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:9751766 DDE increases secretion EXP   6480464 Dichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein CTD PMID:21044676 desferrioxamine B increases expression ISO RGD:69123 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 desferrioxamine B increases secretion ISO RGD:3000 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases secretion ISO RGD:69123 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 desferrioxamine B increases expression ISO RGD:3000 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 dexamethasone multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LEP mRNA CTD PMID:19186324 dexamethasone increases expression ISO RGD:3000 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:23166830 dexamethasone multiple interactions EXP   6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 dexamethasone multiple interactions ISO RGD:69123 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 dexamethasone multiple interactions ISO RGD:69123 6480464 troglitazone inhibits the reaction [Dexamethasone results in increased expression of LEP mRNA]; more ... CTD PMID:10946865 dexamethasone increases secretion ISO RGD:69123 6480464 Dexamethasone results in increased secretion of LEP protein CTD PMID:10946865 dexamethasone increases expression ISO RGD:69123 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:10946865 dexamethasone multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein; more ... CTD PMID:11092516 dexamethasone increases expression ISO RGD:3000 6480464 Dexamethasone results in increased expression of LEP protein CTD PMID:15824971 dextran sulfate multiple interactions EXP   6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA; more ... CTD PMID:19931517 diazoxide decreases secretion ISO RGD:69123 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 diazoxide increases expression ISO RGD:3000 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 diazoxide multiple interactions ISO RGD:3000 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 diazoxide decreases secretion ISO RGD:3000 6480464 Diazoxide results in decreased secretion of LEP protein CTD PMID:10780946 diazoxide multiple interactions ISO RGD:3000 6480464 Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 diazoxide multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 diethylstilbestrol multiple interactions EXP   6480464 Diethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 dioxygen decreases expression EXP   6480464 Oxygen deficiency results in decreased expression of LEP mRNA CTD PMID:21531777 dioxygen increases secretion ISO RGD:69123 6480464 Oxygen deficiency results in increased secretion of LEP protein CTD PMID:12032628 dioxygen increases expression ISO RGD:69123 6480464 Oxygen deficiency results in increased expression of LEP mRNA CTD PMID:12032628 dipyridamole multiple interactions ISO RGD:3000 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 dipyridamole increases expression ISO RGD:3000 6480464 Dipyridamole results in increased expression of LEP protein CTD PMID:10746648 disodium selenite decreases expression EXP   6480464 Sodium Selenite results in decreased expression of LEP mRNA CTD PMID:23274088 dobutamine decreases secretion ISO RGD:69123 6480464 Dobutamine results in decreased secretion of LEP protein CTD PMID:11022189 dobutamine decreases expression EXP   6480464 Dobutamine results in decreased expression of LEP mRNA; more ... CTD PMID:9002984 DPCPX multiple interactions ISO RGD:3000 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 elemental selenium decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 enalapril increases response to substance EXP   6480464 LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 ethanol multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein; more ... CTD PMID:18227024 fenoterol decreases secretion ISO RGD:69123 6480464 Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 flufenamic acid multiple interactions EXP   6480464 Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 fonofos increases methylation ISO RGD:69123 6480464 Fonofos results in increased methylation of LEP promoter CTD PMID:22847954 fructose increases secretion ISO RGD:3000 6480464 Fructose results in increased secretion of LEP protein CTD PMID:19165636 fructose multiple interactions ISO RGD:3000 6480464 atorvastatin affects the reaction [Fructose results in increased expression of LEP protein] CTD PMID:21122807 fructose increases expression ISO RGD:3000 6480464 Fructose results in increased expression of LEP protein CTD PMID:18627777 PMID:21122807 fructose increases secretion ISO RGD:3000 6480464 Fructose results in increased secretion of LEP protein CTD PMID:10780946 PMID:19165636 fructose increases expression ISO RGD:3000 6480464 Fructose results in increased expression of LEP mRNA CTD PMID:19165636 PMID:11741341 fructose increases expression ISO RGD:3000 6480464 Fructose results in increased expression of LEP mRNA CTD PMID:11741341 PMID:19165636 fructose increases expression ISO RGD:3000 6480464 Fructose results in increased expression of LEP protein CTD PMID:18627777 gamma-hexachlorocyclohexane affects expression ISO RGD:3000 6480464 Lindane affects the expression of LEP mRNA CTD PMID:17785943 genistein decreases expression EXP   6480464 Genistein results in decreased expression of LEP protein; more ... CTD PMID:18359623 genistein decreases response to substance ISO RGD:69123 6480464 Genistein results in decreased susceptibility to LEP protein CTD PMID:11342529 genistein multiple interactions ISO RGD:69123 6480464 Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]; more ... CTD PMID:11342529 glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP protein CTD PMID:18627777 glucose increases expression ISO RGD:3000 6480464 Glucose results in increased expression of LEP mRNA CTD PMID:10780946 glucose increases secretion ISO RGD:3000 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 glucose multiple interactions ISO RGD:3000 6480464 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; more ... CTD PMID:10780946 glucose increases response to substance ISO RGD:69123 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 glucose multiple interactions ISO RGD:69123 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]; more ... CTD PMID:11342529 glucose multiple interactions ISO RGD:3000 6480464 LEP promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:9751766 hydrogen peroxide affects expression ISO RGD:69123 6480464 Hydrogen Peroxide affects the expression of LEP mRNA CTD PMID:21179406 indinavir multiple interactions ISO RGD:69123 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] CTD PMID:17668557 indinavir multiple interactions EXP   6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 indinavir decreases expression ISO RGD:69123 6480464 Indinavir results in decreased expression of LEP protein CTD PMID:17668557 indomethacin multiple interactions ISO RGD:3000 6480464 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein]; more ... CTD PMID:16280098 indomethacin multiple interactions ISO RGD:69123 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 indomethacin increases expression ISO RGD:3000 6480464 Indomethacin results in increased expression of LEP protein CTD PMID:16280098 indomethacin multiple interactions ISO RGD:3000 6480464 LEP protein inhibits the reaction [Indomethacin results in decreased activity of GSR protein] CTD PMID:18181030 isoprenaline decreases secretion ISO RGD:69123 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 isoprenaline increases expression ISO RGD:3000 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 isoprenaline multiple interactions ISO RGD:3000 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 isoprenaline multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 kainic acid decreases response to substance EXP   6480464 LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 lamivudine multiple interactions EXP   6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA; more ... CTD PMID:16931933 lanthanum atom multiple interactions EXP   6480464 Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 lipoic acid decreases secretion EXP   6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 lipoic acid decreases expression ISO RGD:3000 6480464 Thioctic Acid results in decreased expression of LEP mRNA; more ... CTD PMID:21351249 lipoic acid decreases expression EXP   6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 loganin affects expression EXP   6480464 loganin affects the expression of LEP protein CTD PMID:21864639 LY294002 decreases expression EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 LY294002 decreases secretion EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 PMID:21351249 LY294002 decreases expression EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 PMID:21351249 LY294002 decreases secretion EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 manganese atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 manganese(0) decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 melatonin decreases expression ISO RGD:69123 6480464 Melatonin results in decreased expression of LEP mRNA CTD PMID:20738756 melatonin decreases expression ISO RGD:3000 6480464 Melatonin results in decreased expression of LEP protein CTD PMID:19028472 menadione multiple interactions ISO RGD:69123 6480464 1,2-linoleoylphosphatidylcholine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]; more ... CTD PMID:16996477 menadione increases expression ISO RGD:69123 6480464 Vitamin K 3 results in increased expression of LEP mRNA CTD PMID:16996477 mercury dichloride decreases expression EXP   6480464 Mercuric Chloride results in decreased expression of LEP mRNA CTD PMID:22019852 mercury dichloride decreases secretion EXP   6480464 Mercuric Chloride results in decreased secretion of LEP protein CTD PMID:22019852 metformin increases expression EXP   6480464 Metformin results in increased expression of LEP protein CTD PMID:20869956 methadone increases expression ISO RGD:69123 6480464 Methadone results in increased expression of LEP protein CTD PMID:15717844 methotrexate affects expression EXP   6480464 Methotrexate affects the expression of LEP mRNA CTD PMID:18502557 mevalonic acid multiple interactions EXP   6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]; more ... CTD PMID:19254925 monocrotaline multiple interactions EXP   6480464 TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 N-methyl-N-nitrosurea multiple interactions EXP   6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; more ... CTD PMID:16822543 N-methyl-N-nitrosurea increases expression EXP   6480464 Methylnitrosourea results in increased expression of LEP protein CTD PMID:16822543 N-nitrosodimethylamine increases expression ISO RGD:3000 6480464 Dimethylnitrosamine results in increased expression of LEP mRNA; more ... CTD PMID:15798949 naproxen multiple interactions ISO RGD:3000 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; more ... CTD PMID:22150557 nevirapine increases expression ISO RGD:69123 6480464 Nevirapine results in increased expression of LEP mRNA CTD PMID:21619898 nickel dichloride multiple interactions ISO RGD:69123 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 nickel dichloride multiple interactions ISO RGD:3000 6480464 nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 nickel sulfate multiple interactions ISO RGD:69123 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA CTD PMID:18832182 nickel sulfate increases expression ISO RGD:69123 6480464 nickel sulfate results in increased expression of LEP mRNA CTD PMID:18832182 nicotinic acid increases expression EXP   6480464 Niacin results in increased expression of LEP mRNA CTD PMID:21236357 nicotinic acid increases expression ISO RGD:69123 6480464 Niacin results in increased expression of LEP protein CTD PMID:16887123 nitric oxide multiple interactions ISO RGD:69123 6480464 LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 olanzapine increases expression ISO RGD:69123 6480464 olanzapine results in increased expression of LEP protein CTD PMID:11927762 PMID:19512971 olanzapine increases expression ISO RGD:69123 6480464 olanzapine results in increased expression of LEP protein CTD PMID:19512971 PMID:11927762 oleanolic acid increases expression EXP   6480464 Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 oleic acid decreases expression EXP   6480464 Oleic Acid results in decreased expression of LEP mRNA CTD PMID:9002984 ozone multiple interactions EXP   6480464 LEP gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]; more ... CTD PMID:12794034 ozone increases response to substance EXP   6480464 LEP gene mutant form results in increased susceptibility to Ozone CTD PMID:12794034 PMID:16002559 ozone increases response to substance EXP   6480464 LEP protein results in increased susceptibility to Ozone CTD PMID:12794034 ozone increases response to substance EXP   6480464 LEP gene mutant form results in increased susceptibility to Ozone CTD PMID:16002559 PMID:12794034 paracetamol multiple interactions EXP   6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA; more ... CTD PMID:17585979 paracetamol affects expression EXP   6480464 Acetaminophen affects the expression of LEP mRNA CTD PMID:17562736 paraquat affects expression ISO RGD:3000 6480464 Paraquat affects the expression of LEP mRNA CTD PMID:18198484 parathion increases methylation ISO RGD:69123 6480464 Parathion results in increased methylation of LEP promoter CTD PMID:22847954 perindopril decreases expression ISO RGD:3000 6480464 Perindopril results in decreased expression of LEP protein CTD PMID:18083506 phencyclidine increases expression EXP   6480464 Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 phenobarbital multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA; more ... CTD PMID:14758566 pioglitazone increases expression ISO RGD:3000 6480464 pioglitazone results in increased expression of LEP protein CTD PMID:15655531 pirinixic acid multiple interactions EXP   6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 pitavastatin multiple interactions EXP   6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; more ... CTD PMID:18323514 pravastatin multiple interactions EXP   6480464 Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; more ... CTD PMID:18323514 progesterone decreases secretion ISO RGD:69123 6480464 Progesterone results in decreased secretion of LEP protein CTD PMID:16048798 progesterone increases expression EXP   6480464 Progesterone results in increased expression of LEP mRNA CTD PMID:15713686 propranolol multiple interactions ISO RGD:69123 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 propylparaben increases expression EXP   6480464 propylparaben results in increased expression of LEP mRNA CTD PMID:22956630 propylparaben decreases expression ISO RGD:69123 6480464 propylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 prostaglandin E2 increases secretion ISO RGD:3000 6480464 Dinoprostone results in increased secretion of LEP protein CTD PMID:11060898 prostaglandin E2 increases expression ISO RGD:3000 6480464 Dinoprostone results in increased expression of LEP protein CTD PMID:11060898 prostaglandin E2 increases abundance ISO RGD:3000 6480464 LEP protein results in increased abundance of Dinoprostone CTD PMID:16015682 pyruvic acid increases secretion ISO RGD:3000 6480464 Pyruvic Acid results in increased secretion of LEP protein CTD PMID:10780946 pyruvic acid multiple interactions ISO RGD:3000 6480464 INS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein] CTD PMID:10780946 quercetin multiple interactions EXP   6480464 Quercetin inhibits the reaction [Azoxymethane results in increased expression of LEP protein] CTD PMID:19914226 quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of LEP mRNA CTD PMID:19914226 quercetin decreases secretion EXP   6480464 Quercetin results in decreased secretion of LEP protein CTD PMID:19914226 ramipril multiple interactions ISO RGD:69123 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP]; more ... CTD PMID:17483542 ramipril decreases expression ISO RGD:69123 6480464 Ramipril results in decreased expression of LEP CTD PMID:19059660 reserpine increases expression EXP   6480464 Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 resveratrol decreases expression ISO RGD:69123 6480464 resveratrol results in decreased expression of LEP mRNA CTD PMID:21713995 rosiglitazone decreases expression ISO RGD:69123 6480464 rosiglitazone results in decreased expression of LEP mRNA CTD PMID:15949695 rosiglitazone multiple interactions EXP   6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 rosiglitazone multiple interactions ISO RGD:69123 6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA; more ... CTD PMID:23086663 rosiglitazone increases expression EXP   6480464 rosiglitazone results in increased expression of LEP mRNA CTD PMID:22763116 rosiglitazone increases expression ISO RGD:69123 6480464 rosiglitazone results in increased expression of LEP mRNA CTD PMID:12814394 PMID:22763116 rosiglitazone decreases expression ISO RGD:69123 6480464 rosiglitazone results in decreased expression of LEP mRNA CTD PMID:15949695 PMID:10548525 rosiglitazone decreases expression ISO RGD:3000 6480464 rosiglitazone results in decreased expression of LEP protein CTD PMID:15998575 rosiglitazone increases secretion ISO RGD:69123 6480464 rosiglitazone results in increased secretion of LEP protein CTD PMID:12814394 rosiglitazone increases expression ISO RGD:69123 6480464 rosiglitazone results in increased expression of LEP mRNA CTD PMID:12814394 rosiglitazone decreases expression ISO RGD:69123 6480464 rosiglitazone results in decreased expression of LEP mRNA CTD PMID:10548525 PMID:15949695 rosiglitazone increases expression ISO RGD:69123 6480464 rosiglitazone results in increased expression of LEP protein CTD PMID:18394743 rosiglitazone multiple interactions EXP   6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 rotenone decreases response to substance ISO RGD:69123 6480464 Rotenone results in decreased susceptibility to LEP protein CTD PMID:11342529 rotenone multiple interactions ISO RGD:69123 6480464 Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 roxarsone decreases expression ISO RGD:69123 6480464 Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 S-adenosyl-L-methionine multiple interactions ISO RGD:69123 6480464 S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]; more ... CTD PMID:16996477 saquinavir multiple interactions EXP   6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 selenium atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 simvastatin multiple interactions EXP   6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; more ... CTD PMID:19254925 simvastatin decreases secretion EXP   6480464 Simvastatin results in decreased secretion of LEP protein CTD PMID:19254925 simvastatin decreases expression EXP   6480464 Simvastatin results in decreased expression of LEP mRNA; more ... CTD PMID:19254925 stavudine decreases expression ISO RGD:69123 6480464 Stavudine results in decreased expression of LEP protein CTD PMID:17668557 sumatriptan multiple interactions ISO RGD:3000 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; more ... CTD PMID:22150557 superoxide multiple interactions EXP   6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; more ... CTD PMID:16380530 superoxide multiple interactions ISO RGD:69123 6480464 [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides CTD PMID:11342529 superoxide increases abundance EXP   6480464 LEP protein results in increased abundance of Superoxides CTD PMID:16380530 terbufos increases methylation ISO RGD:69123 6480464 terbufos results in increased methylation of LEP promoter CTD PMID:22847954 terbutaline decreases expression EXP   6480464 Terbutaline results in decreased expression of LEP mRNA; more ... CTD PMID:9002984 tetrachloromethane multiple interactions EXP   6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein]; more ... CTD PMID:12730884 tetrachloromethane multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA; more ... CTD PMID:14758566 tetrachloromethane multiple interactions ISO RGD:3000 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein; more ... CTD PMID:18227024 tetrachloromethane multiple interactions EXP   6480464 LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; more ... CTD PMID:11481614 tetrachloromethane multiple interactions EXP   6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:12586293 thioacetamide decreases response to substance EXP   6480464 LEP gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide increases expression ISO RGD:3000 6480464 Thioacetamide results in increased expression of LEP protein CTD PMID:17621560 thioacetamide multiple interactions ISO RGD:3000 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17621560 thioacetamide multiple interactions EXP   6480464 [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA CTD PMID:16097051 thioacetamide multiple interactions EXP   6480464 LEP protein promotes the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] CTD PMID:11481614 thioacetamide increases response to substance EXP   6480464 LEP protein results in increased susceptibility to Thioacetamide CTD PMID:12085344 thioacetamide multiple interactions EXP   6480464 LEP protein affects the reaction [Thioacetamide results in increased expression of ACTA2 protein]; more ... CTD PMID:12085344 trans-resveratrol decreases expression ISO RGD:69123 6480464 resveratrol results in decreased expression of LEP mRNA CTD PMID:21713995 trichostatin A increases expression ISO RGD:69123 6480464 trichostatin A results in increased expression of LEP mRNA CTD PMID:17502362 trichostatin A multiple interactions ISO RGD:69123 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 troglitazone decreases expression ISO RGD:3000 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:11909685 PMID:15824971 troglitazone decreases expression ISO RGD:69123 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:10946865 PMID:9727893 troglitazone decreases expression ISO RGD:3000 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:15824971 PMID:11909685 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:10753628 troglitazone decreases expression ISO RGD:3000 6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:9502777 troglitazone increases secretion ISO RGD:69123 6480464 troglitazone results in increased secretion of LEP protein CTD PMID:11092516 troglitazone decreases expression ISO RGD:69123 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:9727893 PMID:10946865 troglitazone multiple interactions ISO RGD:69123 6480464 troglitazone inhibits the reaction [Dexamethasone results in increased secretion of LEP protein]; more ... CTD PMID:10946865 troglitazone multiple interactions ISO RGD:69123 6480464 [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein CTD PMID:11092516 ursolic acid increases expression EXP   6480464 ursolic acid results in increased expression of LEP protein CTD PMID:20869956 vanadium atom multiple interactions ISO RGD:3000 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein]; more ... CTD PMID:16195403 vanadium(0) multiple interactions ISO RGD:3000 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein]; more ... CTD PMID:16195403 wortmannin decreases expression EXP   6480464 wortmannin results in decreased expression of LEP mRNA CTD PMID:19254925 wortmannin multiple interactions EXP   6480464 wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 wortmannin decreases secretion EXP   6480464 wortmannin results in decreased secretion of LEP protein CTD PMID:19254925 zidovudine decreases expression ISO RGD:69123 6480464 Zidovudine results in decreased expression of LEP protein CTD PMID:17668557 zidovudine multiple interactions EXP   6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA; more ... CTD PMID:16931933 zinc atom decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc atom increases expression ISO RGD:3000 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 zinc atom decreases expression ISO RGD:69123 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc atom multiple interactions ISO RGD:69123 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]; more ... CTD PMID:18316168 zinc dichloride increases expression ISO RGD:69123 6480464 zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 zinc sulfate decreases expression ISO RGD:3000 6480464 Zinc Sulfate deficiency results in decreased expression of LEP mRNA CTD PMID:11568307 zinc sulfate multiple interactions ISO RGD:3000 6480464 Zinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:11568307 zinc(0) decreases abundance ISO RGD:69123 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 zinc(0) multiple interactions ISO RGD:69123 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]; more ... CTD PMID:18316168 zinc(0) decreases expression ISO RGD:69123 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 zinc(0) increases expression ISO RGD:3000 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) adipose tissue development   IGI MGI:MGI:101761 2290270 MGI:MGI:1355047|PMID:10742101 MGI MGI:MGI:1355047 PMID:10742101 adult feeding behavior   IDA   2290270 MGI:MGI:1203479|PMID:9590691 HGNC MGI:MGI:1203479 PMID:9590691 bile acid metabolic process   IDA   2290270 MGI:MGI:2386518|PMID:12114517 MGI MGI:MGI:2386518 PMID:12114517 bone mineralization involved in bone maturation   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cardiac muscle hypertrophy   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 central nervous system neuron development   IMP MGI:MGI:1856424 2290270 MGI:MGI:1351081|PMID:10592285 MGI MGI:MGI:1351081 PMID:10592285 cholesterol metabolic process   IGI MGI:MGI:88049 2290270 MGI:MGI:3588626|PMID:15995171 MGI MGI:MGI:3588626 PMID:15995171 eating behavior   IGI MGI:MGI:98735 2290270 MGI:MGI:1855732|PMID:10802666 MGI MGI:MGI:1855732 PMID:10802666 energy reserve metabolic process   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 fatty acid catabolic process   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 glucose metabolic process   IMP MGI:MGI:1856424 2290270 MGI:MGI:2449716|PMID:12540600 MGI MGI:MGI:2449716 PMID:12540600 glycerol biosynthetic process   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 hormone metabolic process   IMP MGI:MGI:1856424 2290270 MGI:MGI:3769319|PMID:16513828 MGI MGI:MGI:3769319 PMID:16513828 insulin secretion   IGI MGI:MGI:1343180 2290270 MGI:MGI:3770192|PMID:16141392 MGI MGI:MGI:3770192 PMID:16141392 intracellular signal transduction   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 leptin-mediated signaling pathway   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 leukocyte tethering or rolling   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 lipid metabolic process   IMP MGI:MGI:1856424 2290270 MGI:MGI:2673743|PMID:12815040 MGI MGI:MGI:2673743 PMID:12815040 negative regulation of apoptotic process   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of appetite   IDA   2290270 MGI:MGI:1203479|PMID:9590691 HGNC MGI:MGI:1203479 PMID:9590691 negative regulation of cartilage development   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of glucagon secretion   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 negative regulation of glutamine transport   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of metabolic process   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of transcription from RNA polymerase II promoter   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 negative regulation of vasoconstriction   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 ovulation from ovarian follicle   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 placenta development   ISO UniProtKB:P41159 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cell proliferation   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of developmental growth   ISO UniProtKB:P41159 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of hepatic stellate cell activation   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of insulin receptor signaling pathway   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of ion transport   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of JAK-STAT cascade   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 positive regulation of JAK-STAT cascade   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of MAPK cascade   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of myeloid cell differentiation   IDA   2290270 MGI:MGI:86079|PMID:9057630 MGI MGI:MGI:86079 PMID:9057630 positive regulation of peroxisome proliferator activated receptor signaling pathway   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of protein import into nucleus   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 positive regulation of reactive oxygen species metabolic process   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of STAT protein import into nucleus   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 positive regulation of tyrosine phosphorylation of Stat3 protein   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of blood pressure   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of fat cell differentiation   IGI MGI:MGI:2652843 2290270 MGI:MGI:5444798|PMID:22927639 MGI MGI:MGI:5444798 PMID:22927639 regulation of gluconeogenesis   IMP MGI:MGI:1856424 2290270 MGI:MGI:3769319|PMID:16513828 MGI MGI:MGI:3769319 PMID:16513828 regulation of insulin secretion   IMP MGI:MGI:1856424 2290270 MGI:MGI:3769319|PMID:16513828 MGI MGI:MGI:3769319 PMID:16513828 regulation of intestinal cholesterol absorption   IDA   2290270 MGI:MGI:2386518|PMID:12114517 MGI MGI:MGI:2386518 PMID:12114517 regulation of lipoprotein lipid oxidation   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of metabolic process   IMP MGI:MGI:1856424 2290270 MGI:MGI:3521560|PMID:12925742 MGI MGI:MGI:3521560 PMID:12925742 regulation of protein phosphorylation   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 regulation of steroid biosynthetic process   IMP MGI:MGI:1856424 2290270 MGI:MGI:3769319|PMID:16513828 MGI MGI:MGI:3769319 PMID:16513828 response to dietary excess   IMP MGI:MGI:1856424 2290270 MGI:MGI:3770192|PMID:16141392 MGI MGI:MGI:3770192 PMID:16141392 response to dietary excess   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to dietary excess   IGI MGI:MGI:1343180 2290270 MGI:MGI:3721169|PMID:12177191 MGI MGI:MGI:3721169 PMID:12177191 response to insulin stimulus   IMP MGI:MGI:1856424 2290270 MGI:MGI:3770192|PMID:16141392 MGI MGI:MGI:3770192 PMID:16141392 signal transduction   IEA InterPro:IPR000065 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 tyrosine phosphorylation of STAT protein   IDA   2290270 MGI:MGI:4889014|PMID:21234744 BHF-UCL MGI:MGI:4889014 PMID:21234744 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular region   IEA InterPro:IPR000065 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 extracellular region   IEA UniProtKB-KW:KW-0964 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 extracellular space   IDA   2290270 MGI:MGI:3761982|PMID:17693256 MGI MGI:MGI:3761982 PMID:17693256 extracellular space   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 extracellular space   IDA   2290270 MGI:MGI:1203479|PMID:9590691 HGNC MGI:MGI:1203479 PMID:9590691 extracellular space   IDA   2290270 MGI:MGI:4868567|PMID:20952387 MGI MGI:MGI:4868567 PMID:20952387 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) growth factor activity   IDA   2290270 MGI:MGI:86079|PMID:9057630 MGI MGI:MGI:86079 PMID:9057630 hormone activity   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 peptide hormone receptor binding   ISO UniProtKB:P50596 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein binding   IPI UniProtKB:O89013 2290270 MGI:MGI:86341|PMID:9102398 MGI MGI:MGI:86341 PMID:9102398 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) energy homeostasis pathway   TAS   1625125   RGD   hypoxia inducible factor pathway   ISO RGD:69123 6484113   PID PID:200202 Jak-Stat signaling pathway   IEA RGD:69124 6907045   KEGG mmu:04630 leptin system pathway   TAS   1625125   RGD   External Database Links KEGG Pathway Adipocytokine signaling pathway Cytokine-cytokine receptor interaction Jak-STAT signaling pathway Neuroactive ligand-receptor interaction Pathway Interaction Database HIF-1-alpha transcription factor network (PID:200202) Signaling events mediated by PTP1B (PID:200042) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal acute inflammation   IAGP   5509061   MGI PMID:17023554 abnormal adipocyte glucose uptake   IAGP   5509061   MGI PMID:16804058 abnormal adipose tissue amount   IAGP   5509061   MGI PMID:12897241 abnormal adipose tissue amount   IAGP   5509061   MGI PMID:12453895 abnormal adipose tissue amount   IAGP   5509061   MGI PMID:12000791 abnormal adipose tissue amount   IAGP   5509061   MGI PMID:18682832 abnormal adipose tissue amount   IAGP   5509061   MGI PMID:7815168 abnormal adipose tissue morphology   IAGP   5509061   MGI PMID:10359811 abnormal arteriole morphology   IAGP   5509061   MGI PMID:19502550 abnormal behavior   IAGP   5509061   MGI PMID:16549076 abnormal body size   IAGP   5509061   MGI PMID:14578285 abnormal body temperature   IAGP   5509061   MGI PMID:14578285 abnormal body weight   IAGP   5509061   MGI PMID:9623983 abnormal body weight   IAGP   5509061   MGI PMID:10742101 abnormal body weight   IAGP   5509061   MGI PMID:14578285 abnormal body weight   IAGP   5509061   MGI PMID:17873059 abnormal body weight   IAGP   5509061   MGI PMID:18682832 abnormal body weight   IAGP   5509061   MGI PMID:7800681 abnormal body weight   IAGP   5509061   MGI PMID:7560100 abnormal bone marrow morphology   IAGP   5509061   MGI PMID:22958920 abnormal branching of the mammary ductal tree   IAGP   5509061   MGI PMID:12000791 abnormal cardiovascular system physiology   IAGP   5509061   MGI PMID:16246967 abnormal chemokine secretion   IAGP   5509061   MGI PMID:17023554 abnormal circulating cholesterol level   IAGP   5509061   MGI PMID:11445560 abnormal circulating cholesterol level   IAGP   5509061   MGI PMID:8177042 abnormal circulating corticosterone level   IAGP   5509061   MGI PMID:12897241 abnormal circulating glucose level   IAGP   5509061   MGI PMID:4588246 abnormal circulating glucose level   IAGP   5509061   MGI PMID:12453895 abnormal circulating glucose level   IAGP   5509061   MGI PMID:17873059 abnormal circulating hormone level   IAGP   5509061   MGI PMID:12000791 abnormal circulating insulin level   IAGP   5509061   MGI PMID:12453895 abnormal circulating pancreatic peptide level   IAGP   5509061   MGI PMID:12000791 abnormal circulating testosterone level   IAGP   5509061   MGI PMID:12000791 abnormal cortical plate morphology   IAGP   5509061   MGI PMID:16282354 abnormal corticosterone level   IEA   5509061   MGI   abnormal digestive system physiology   IAGP   5509061   MGI PMID:17023554 abnormal embryonic neuroepithelium morphology   IAGP   5509061   MGI PMID:16282354 abnormal energy expenditure   IAGP   5509061   MGI PMID:12244109 abnormal enzyme/ coenzyme level   IAGP   5509061   MGI PMID:12930764 abnormal epidermal layer morphology   IAGP   5509061   MGI PMID:17130477 abnormal epididymal fat pad morphology   IAGP   5509061   MGI PMID:7815168 abnormal estrous cycle   IAGP   5509061   MGI PMID:12000791 abnormal excitatory postsynaptic currents   IAGP   5509061   MGI PMID:15064421 abnormal fat cell morphology   IAGP   5509061   MGI PMID:15319454 abnormal fat cell morphology   IAGP   5509061   MGI PMID:6393185 abnormal fat cell morphology   IAGP   5509061   MGI PMID:5059196 abnormal fat cell morphology   IAGP   5509061   MGI PMID:17465682 abnormal fat pad morphology   IAGP   5509061   MGI PMID:10742101 abnormal fatty acid beta-oxidation   IAGP   5509061   MGI PMID:22958918 abnormal fatty acid level   IAGP   5509061   MGI PMID:14578285 abnormal fertility/fecundity   IAGP   5509061   MGI PMID:16407534 abnormal fertility/fecundity   IAGP   5509061   MGI PMID:12000791 abnormal food intake   IAGP   5509061   MGI PMID:17550780 abnormal food intake   IAGP   5509061   MGI PMID:14578285 abnormal frequency of paradoxical sleep   IAGP   5509061   MGI PMID:16293682 abnormal gland physiology   IAGP   5509061   MGI PMID:6393185 abnormal gluconeogenesis   IAGP   5509061   MGI PMID:16804058 abnormal gluconeogenesis   IAGP   5509061   MGI PMID:19289822 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:15201286 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:6393185 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:17465682 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:17003330 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:16804058 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:12244109 abnormal glucose homeostasis   IAGP   5509061   MGI PMID:12897241 abnormal glucose tolerance   IAGP   5509061   MGI PMID:12897241 abnormal glycogen homeostasis   IAGP   5509061   MGI PMID:16804058 abnormal gonadal fat pad morphology   IAGP   5509061   MGI PMID:18682832 abnormal gonadal fat pad morphology   IAGP   5509061   MGI PMID:21151569 abnormal gonadal fat pad morphology   IAGP   5509061   MGI PMID:17003330 abnormal hormone level   IAGP   5509061   MGI PMID:6393185 abnormal inhibitory postsynaptic currents   IAGP   5509061   MGI PMID:15064421 abnormal insulin secretion   IAGP   5509061   MGI PMID:7835283 abnormal insulin secretion   IAGP   5509061   MGI PMID:17465682 abnormal insulin secretion   IAGP   5509061   MGI PMID:8360782 abnormal interstitial cell of Cajal morphology   IAGP   5509061   MGI PMID:19917283 abnormal intestinal epithelium morphology   IAGP   5509061   MGI PMID:17023554 abnormal intestinal goblet cell morphology   IAGP   5509061   MGI PMID:16455789 abnormal intestinal mucosa morphology   IAGP   5509061   MGI PMID:16455789 abnormal intestine morphology   IAGP   5509061   MGI PMID:12453895 abnormal Leydig cell morphology   IAGP   5509061   MGI PMID:12000791 abnormal lipid homeostasis   IAGP   5509061   MGI PMID:12244109 abnormal lipid homeostasis   IAGP   5509061   MGI PMID:19883618 abnormal lipid homeostasis   IAGP   5509061   MGI PMID:17465682 abnormal lipid homeostasis   IAGP   5509061   MGI PMID:15319454 abnormal lipid level   IAGP   5509061   MGI PMID:17465682 abnormal liver morphology   IAGP   5509061   MGI PMID:17465682 abnormal liver size   IAGP   5509061   MGI PMID:14578285 abnormal liver weight   IAGP   5509061   MGI PMID:7815168 abnormal locomotor behavior   IAGP   5509061   MGI PMID:17465682 abnormal long bone epiphyseal plate morphology   IAGP   5509061   MGI PMID:16039170 abnormal long bone epiphyseal plate proliferative zone   IAGP   5509061   MGI PMID:16039170 abnormal long bone hypertrophic chondrocyte zone   IAGP   5509061   MGI PMID:16039170 abnormal maternal nurturing   IAGP   5509061   MGI PMID:16407534 abnormal metabolism   IAGP   5509061   MGI PMID:10359811 abnormal microglial cell physiology   IAGP   5509061   MGI PMID:12107823 abnormal muscle cell glucose uptake   IAGP   5509061   MGI PMID:16804058 abnormal muscle contractility   IAGP   5509061   MGI PMID:12355168 abnormal muscle morphology   IAGP   5509061   MGI PMID:19528970 abnormal myocardial fiber morphology   IAGP   5509061   MGI PMID:12885755 abnormal myocardial fiber morphology   IAGP   5509061   MGI PMID:16612592 abnormal myocardial fiber morphology   IAGP   5509061   MGI PMID:16394172 abnormal myocardial fiber physiology   IAGP   5509061   MGI PMID:16394172 abnormal neuron morphology   IAGP   5509061   MGI PMID:15064421 abnormal osteoclast differentiation   IAGP   5509061   MGI PMID:10660043 abnormal ovarian follicle morphology   IAGP   5509061   MGI PMID:12000791 abnormal ovarian folliculogenesis   IAGP   5509061   MGI PMID:12000791 abnormal oxygen consumption   IAGP   5509061   MGI PMID:7815168 abnormal oxygen consumption   IAGP   5509061   MGI PMID:12244109 abnormal oxygen consumption   IAGP   5509061   MGI PMID:7800681 abnormal pain threshold   IAGP   5509061   MGI PMID:19620723 abnormal pancreatic beta cell morphology   IAGP   5509061   MGI PMID:6393185 abnormal pancreatic beta cell physiology   IAGP   5509061   MGI PMID:4588246 abnormal pancreatic islet morphology   IAGP   5509061   MGI PMID:12136396 abnormal pancreatic islet morphology   IAGP   5509061   MGI PMID:17465682 abnormal podocyte morphology   IAGP   5509061   MGI PMID:20634301 abnormal postnatal growth   IAGP   5509061   MGI PMID:22232663 abnormal postnatal growth   IAGP   5509061   MGI PMID:508700 abnormal protein level   IAGP   5509061   MGI PMID:7800681 abnormal respiratory electron transport chain   IAGP   5509061   MGI PMID:16246967 abnormal retinal vasculature morphology   IAGP   5509061   MGI PMID:15331557 abnormal skeletal muscle fiber type ratio   IAGP   5509061   MGI PMID:19528970 abnormal skeletal muscle morphology   IAGP   5509061   MGI PMID:17003330 abnormal skeletal muscle morphology   IAGP   5509061   MGI PMID:17465682 abnormal skeleton development   IAGP   5509061   MGI PMID:10660043 abnormal sleep pattern   IAGP   5509061   MGI PMID:16293682 abnormal sperm number   IAGP   5509061   MGI PMID:12000791 abnormal sympathetic nervous system physiology   IAGP   5509061   MGI PMID:19103808 abnormal tumor necrosis factor level   IAGP   5509061   MGI PMID:11481248 abnormal urine catecholamine level   IAGP   5509061   MGI PMID:1382044 abnormal urine homeostasis   IAGP   5509061   MGI PMID:1382044 abnormal vagina orifice morphology   IAGP   5509061   MGI PMID:12000791 abnormal vascular wound healing   IAGP   5509061   MGI PMID:17095713 abnormal white adipose tissue amount   IAGP   5509061   MGI PMID:17003330 absent corpus luteum   IAGP   5509061   MGI PMID:12000791 albuminuria   IAGP   5509061   MGI PMID:20634301 allodynia   IAGP   5509061   MGI PMID:19620723 atherosclerotic lesions   IAGP   5509061   MGI PMID:11445560 decreased activity of thyroid   IAGP   5509061   MGI PMID:6393185 decreased adiponectin level   IAGP   5509061   MGI PMID:17003330 decreased adiponectin level   IAGP   5509061   MGI PMID:17465682 decreased body length   IAGP   5509061   MGI PMID:14824537 decreased body size   IAGP   5509061   MGI PMID:10742101 decreased body size   IAGP   5509061   MGI PMID:19289822 decreased body temperature   IAGP   5509061   MGI PMID:22232663 decreased body temperature   IAGP   5509061   MGI PMID:840297 decreased body temperature   IAGP   5509061   MGI PMID:21151569 decreased body temperature   IAGP   5509061   MGI PMID:16469807 decreased body weight   IAGP   5509061   MGI PMID:22232663 decreased body weight   IAGP   5509061   MGI PMID:22541436 decreased body weight   IAGP   5509061   MGI PMID:10742101 decreased body weight   IAGP   5509061   MGI PMID:21298050 decreased body weight   IAGP   5509061   MGI PMID:19883618 decreased body weight   IAGP   5509061   MGI PMID:17003330 decreased body weight   IAGP   5509061   MGI PMID:12126735 decreased body weight   IAGP   5509061   MGI PMID:16407534 decreased body weight   IAGP   5509061   MGI PMID:15064421 decreased body weight   IAGP   5509061   MGI PMID:12244109 decreased body weight   IAGP   5509061   MGI PMID:12447443 decreased body weight   IAGP   5509061   MGI PMID:21969596 decreased bone mass   IAGP   5509061   MGI PMID:6393185 decreased cardiac muscle contractility   IAGP   5509061   MGI PMID:16394172 decreased cardiac muscle contractility   IAGP   5509061   MGI PMID:16612592 decreased CD4-positive T cell number   IAGP   5509061   MGI PMID:20068132 decreased circulating cholesterol level   IAGP   5509061   MGI PMID:15319454 decreased circulating cholesterol level   IAGP   5509061   MGI PMID:19883618 decreased circulating cholesterol level   IAGP   5509061   MGI PMID:16804058 decreased circulating corticosterone level   IAGP   5509061   MGI PMID:12453895 decreased circulating free fatty acid level   IAGP   5509061   MGI PMID:18682832 decreased circulating free fatty acid level   IAGP   5509061   MGI PMID:12126735 decreased circulating glucose level   IAGP   5509061   MGI PMID:12897241 decreased circulating glucose level   IAGP   5509061   MGI PMID:16879220 decreased circulating glucose level   IAGP   5509061   MGI PMID:12126735 decreased circulating glucose level   IAGP   5509061   MGI PMID:17068142 decreased circulating glucose level   IAGP   5509061   MGI PMID:16407534 decreased circulating glucose level   IAGP   5509061   MGI PMID:16804058 decreased circulating glucose level   IAGP   5509061   MGI PMID:12540600 decreased circulating glucose level   IAGP   5509061   MGI PMID:12447443 decreased circulating glucose level   IAGP   5509061   MGI PMID:19103808 decreased circulating HDL cholesterol level   IAGP   5509061   MGI PMID:15319454 decreased circulating insulin level   IAGP   5509061   MGI PMID:21998599 decreased circulating insulin level   IAGP   5509061   MGI PMID:19289822 decreased circulating insulin level   IAGP   5509061   MGI PMID:16879220 decreased circulating insulin level   IAGP   5509061   MGI PMID:17465682 decreased circulating insulin level   IAGP   5509061   MGI PMID:16804058 decreased circulating insulin level   IAGP   5509061   MGI PMID:15319454 decreased circulating insulin level   IAGP   5509061   MGI PMID:18654634 decreased circulating insulin level   IAGP   5509061   MGI PMID:12244109 decreased circulating insulin level   IAGP   5509061   MGI PMID:12447443 decreased circulating insulin level   IAGP   5509061   MGI PMID:10359811 decreased circulating LDL cholesterol level   IAGP   5509061   MGI PMID:15319454 decreased circulating LDL cholesterol level   IAGP   5509061   MGI PMID:12126735 decreased circulating testosterone level   IAGP   5509061   MGI PMID:12000791 decreased circulating testosterone level   IAGP   5509061   MGI PMID:12453895 decreased circulating triglyceride level   IAGP   5509061   MGI PMID:18682832 decreased circulating triglyceride level   IAGP   5509061   MGI PMID:18941143 decreased circulating triglyceride level   IAGP   5509061   MGI PMID:16804058 decreased circulating tumor necrosis factor level   IAGP   5509061   MGI PMID:12107823 decreased core body temperature   IAGP   5509061   MGI PMID:17550780 decreased eating behavior   IAGP   5509061   MGI PMID:22232663 decreased epididymal fat pad weight   IAGP   5509061   MGI PMID:12453895 decreased epididymal fat pad weight   IAGP   5509061   MGI PMID:21298050 decreased fat cell size   IAGP   5509061   MGI PMID:17003330 decreased food intake   IAGP   5509061   MGI PMID:7560100 decreased food intake   IAGP   5509061   MGI PMID:15064421 decreased gonadal fat pad weight   IAGP   5509061   MGI PMID:21969596 decreased inguinal fat pad weight   IAGP   5509061   MGI PMID:21969596 decreased inguinal fat pad weight   IAGP   5509061   MGI PMID:10742101 decreased insulin secretion   IAGP   5509061   MGI PMID:19103808 decreased lean body mass   IAGP   5509061   MGI PMID:12453895 decreased length of long bones   IAGP   5509061   MGI PMID:16039170 decreased liver cholesterol level   IAGP   5509061   MGI PMID:15319454 decreased liver triglyceride level   IAGP   5509061   MGI PMID:15319454 decreased liver triglyceride level   IAGP   5509061   MGI PMID:19883618 decreased liver triglyceride level   IAGP   5509061   MGI PMID:17465682 decreased liver triglyceride level   IAGP   5509061   MGI PMID:16804058 decreased liver weight   IAGP   5509061   MGI PMID:19883618 decreased liver weight   IAGP   5509061   MGI PMID:21298050 decreased mesenteric fat pad weight   IAGP   5509061   MGI PMID:12453895 decreased mesenteric fat pad weight   IAGP   5509061   MGI PMID:10742101 decreased neuron number   IAGP   5509061   MGI PMID:22232663 decreased NK cell number   IAGP   5509061   MGI PMID:16998795 decreased oxygen consumption   IAGP   5509061   MGI PMID:7815168 decreased pancreatic beta cell mass   IAGP   5509061   MGI PMID:19289822 decreased pancreatic beta cell number   IAGP   5509061   MGI PMID:12136396 decreased pancreatic beta cell number   IAGP   5509061   MGI PMID:11078464 decreased pancreatic beta cell number   IAGP   5509061   MGI PMID:19289822 decreased pancreatic beta cell number   IAGP   5509061   MGI PMID:18654634 decreased respiratory quotient   IAGP   5509061   MGI PMID:17465682 decreased respiratory quotient   IAGP   5509061   MGI PMID:16469807 decreased retroperitoneal fat pad weight   IAGP   5509061   MGI PMID:21298050 decreased seminal vesicle weight   IAGP   5509061   MGI PMID:12000791 decreased skeletal muscle fiber size   IAGP   5509061   MGI PMID:19528970 decreased skeletal muscle mass   IAGP   5509061   MGI PMID:19528970 decreased splenocyte number   IAGP   5509061   MGI PMID:20068132 decreased susceptibility to diet-induced obesity   IAGP   5509061   MGI PMID:15319454 decreased susceptibility to hepatic steatosis   IAGP   5509061   MGI PMID:15319454 decreased susceptibility to hepatic steatosis   IAGP   5509061   MGI PMID:16804058 decreased T cell proliferation   IAGP   5509061   MGI PMID:20068132 decreased testis weight   IAGP   5509061   MGI PMID:12000791 decreased testis weight   IAGP   5509061   MGI PMID:12453895 decreased total body fat amount   IAGP   5509061   MGI PMID:17003330 decreased triglyceride level   IAGP   5509061   MGI PMID:17465682 disorganized pancreatic islets   IAGP   5509061   MGI PMID:17465682 disorganized pancreatic islets   IAGP   5509061   MGI PMID:11078464 enhanced fertility   IAGP   5509061   MGI PMID:22232663 enlarged kidney   IAGP   5509061   MGI PMID:20634301 enlarged myocardial fiber   IAGP   5509061   MGI PMID:16394172 enlarged pancreatic islets   IAGP   5509061   MGI PMID:4588246 enlarged pancreatic islets   IAGP   5509061   MGI PMID:17465682 expanded mesangial matrix   IAGP   5509061   MGI PMID:20634301 female infertility   IAGP   5509061   MGI PMID:22232663 female infertility   IAGP   5509061   MGI PMID:6393185 female infertility   IAGP   5509061   MGI PMID:12000791 female infertility   IAGP   5509061   MGI PMID:17550780 fragmentation of sleep/wake states   IAGP   5509061   MGI PMID:16293682 glomerulosclerosis   IAGP   5509061   MGI PMID:20634301 heart left ventricle hypertrophy   IAGP   5509061   MGI PMID:12885755 hepatic steatosis   IAGP   5509061   MGI PMID:17482547 hepatic steatosis   IAGP   5509061   MGI PMID:21151569 hepatic steatosis   IAGP   5509061   MGI PMID:17465682 hepatic steatosis   IAGP   5509061   MGI PMID:17003330 hepatic steatosis   IAGP   5509061   MGI PMID:12897241 hepatic steatosis   IAGP   5509061   MGI PMID:22958918 hyperalgesia   IAGP   5509061   MGI PMID:19620723 hyperglycemia   IAGP   5509061   MGI PMID:20634301 hyperglycemia   IAGP   5509061   MGI PMID:6393185 hyperglycemia   IAGP   5509061   MGI PMID:19917283 hyperglycemia   IAGP   5509061   MGI PMID:17465682 hyperglycemia   IAGP   5509061   MGI PMID:12453895 hyperglycemia   IAGP   5509061   MGI PMID:18654634 hyperglycemia   IAGP   5509061   MGI PMID:4588246 hyperglycemia   IAGP   5509061   MGI PMID:17550780 hyperglycemia   IAGP   5509061   MGI PMID:12136396 hyperglycemia   IAGP   5509061   MGI PMID:11078464 hyperglycemia   IAGP   5509061   MGI PMID:15201286 hyperlipidemia   IAGP   5509061   MGI PMID:11445560 hypersecretion of corticosterone   IAGP   5509061   MGI PMID:6393185 hypoactivity   IAGP   5509061   MGI PMID:12897241 hypoactivity   IAGP   5509061   MGI PMID:17465682 hypoactivity   IAGP   5509061   MGI PMID:17550780 hypoactivity   IAGP   5509061   MGI PMID:16293682 hypoglycemia   IAGP   5509061   MGI PMID:4588246 hypotension   IAGP   5509061   MGI PMID:20634301 impaired adaptive thermogenesis   IAGP   5509061   MGI PMID:12897241 impaired adaptive thermogenesis   IAGP   5509061   MGI PMID:16469807 impaired adaptive thermogenesis   IAGP   5509061   MGI PMID:840297 impaired adaptive thermogenesis   IAGP   5509061   MGI PMID:6393185 impaired glucose tolerance   IAGP   5509061   MGI PMID:14578285 impaired glucose tolerance   IAGP   5509061   MGI PMID:6393185 impaired glucose tolerance   IAGP   5509061   MGI PMID:21151569 impaired glucose tolerance   IAGP   5509061   MGI PMID:15319454 impaired glucose tolerance   IAGP   5509061   MGI PMID:18654634 impaired glucose tolerance   IAGP   5509061   MGI PMID:16326714 impaired glucose tolerance   IAGP   5509061   MGI PMID:16394172 impaired glucose tolerance   IAGP   5509061   MGI PMID:22958918 impaired glucose tolerance   IAGP   5509061   MGI PMID:11481248 improved glucose tolerance   IAGP   5509061   MGI PMID:22232663 improved glucose tolerance   IAGP   5509061   MGI PMID:22541436 improved glucose tolerance   IAGP   5509061   MGI PMID:19103808 improved glucose tolerance   IAGP   5509061   MGI PMID:16804058 improved glucose tolerance   IAGP   5509061   MGI PMID:12540600 improved glucose tolerance   IAGP   5509061   MGI PMID:18682832 increased adrenocorticotropin level   IAGP   5509061   MGI PMID:6393185 increased blood urea nitrogen level   IAGP   5509061   MGI PMID:20634301 increased body length   IAGP   5509061   MGI PMID:21151569 increased body weight   IAGP   5509061   MGI PMID:20634301 increased body weight   IAGP   5509061   MGI PMID:16879220 increased body weight   IAGP   5509061   MGI PMID:21151569 increased body weight   IAGP   5509061   MGI PMID:17465682 increased body weight   IAGP   5509061   MGI PMID:12453895 increased body weight   IAGP   5509061   MGI PMID:12000791 increased body weight   IAGP   5509061   MGI PMID:16804058 increased body weight   IAGP   5509061   MGI PMID:12897241 increased body weight   IAGP   5509061   MGI PMID:20368432 increased bone mass   IAGP   5509061   MGI PMID:10660043 increased bone mass   IAGP   5509061   MGI PMID:14978271 increased brown adipose tissue amount   IAGP   5509061   MGI PMID:21151569 increased brown fat cell lipid droplet size   IAGP   5509061   MGI PMID:21151569 increased cholesterol level   IAGP   5509061   MGI PMID:20634301 increased circulating cholesterol level   IAGP   5509061   MGI PMID:11445560 increased circulating cholesterol level   IAGP   5509061   MGI PMID:16879220 increased circulating cholesterol level   IAGP   5509061   MGI PMID:21151569 increased circulating cholesterol level   IAGP   5509061   MGI PMID:12453895 increased circulating cholesterol level   IAGP   5509061   MGI PMID:12126735 increased circulating cholesterol level   IAGP   5509061   MGI PMID:8177042 increased circulating corticosterone level   IAGP   5509061   MGI PMID:10660043 increased circulating corticosterone level   IAGP   5509061   MGI PMID:12453895 increased circulating corticosterone level   IAGP   5509061   MGI PMID:12000791 increased circulating free fatty acid level   IAGP   5509061   MGI PMID:12244109 increased circulating free fatty acid level   IAGP   5509061   MGI PMID:16879220 increased circulating free fatty acid level   IAGP   5509061   MGI PMID:17465682 increased circulating free fatty acid level   IAGP   5509061   MGI PMID:15319454 increased circulating glucose level   IAGP   5509061   MGI PMID:21998599 increased circulating glucose level   IAGP   5509061   MGI PMID:19289822 increased circulating glucose level   IAGP   5509061   MGI PMID:16879220 increased circulating glucose level   IAGP   5509061   MGI PMID:21151569 increased circulating glucose level   IAGP   5509061   MGI PMID:19883618 increased circulating glucose level   IAGP   5509061   MGI PMID:17465682 increased circulating glucose level   IAGP   5509061   MGI PMID:17003330 increased circulating glucose level   IAGP   5509061   MGI PMID:15319454 increased circulating glucose level   IAGP   5509061   MGI PMID:22958918 increased circulating glucose level   IAGP   5509061   MGI PMID:17482547 increased circulating HDL cholesterol level   IAGP   5509061   MGI PMID:11445560 increased circulating HDL cholesterol level   IAGP   5509061   MGI PMID:12126735 increased circulating HDL cholesterol level   IAGP   5509061   MGI PMID:8177042 increased circulating insulin level   IAGP   5509061   MGI PMID:15201286 increased circulating insulin level   IAGP   5509061   MGI PMID:16879220 increased circulating insulin level   IAGP   5509061   MGI PMID:6393185 increased circulating insulin level   IAGP   5509061   MGI PMID:21151569 increased circulating insulin level   IAGP   5509061   MGI PMID:19883618 increased circulating insulin level   IAGP   5509061   MGI PMID:17465682 increased circulating insulin level   IAGP   5509061   MGI PMID:12453895 increased circulating insulin level   IAGP   5509061   MGI PMID:12000791 increased circulating insulin level   IAGP   5509061   MGI PMID:17003330 increased circulating insulin level   IAGP   5509061   MGI PMID:12540600 increased circulating insulin level   IAGP   5509061   MGI PMID:4588246 increased circulating insulin level   IAGP   5509061   MGI PMID:19103808 increased circulating insulin level   IAGP   5509061   MGI PMID:17550780 increased circulating insulin level   IAGP   5509061   MGI PMID:16394172 increased circulating insulin level   IAGP   5509061   MGI PMID:12136396 increased circulating insulin level   IAGP   5509061   MGI PMID:12897241 increased circulating insulin level   IAGP   5509061   MGI PMID:11078464 increased circulating insulin level   IAGP   5509061   MGI PMID:11481248 increased circulating LDL cholesterol level   IAGP   5509061   MGI PMID:8177042 increased circulating leptin level   IAGP   5509061   MGI PMID:12000791 increased circulating leptin level   IAGP   5509061   MGI PMID:21151569 increased circulating triglyceride level   IAGP   5509061   MGI PMID:20634301 increased circulating triglyceride level   IAGP   5509061   MGI PMID:18941143 increased circulating triglyceride level   IAGP   5509061   MGI PMID:16879220 increased circulating triglyceride level   IAGP   5509061   MGI PMID:21151569 increased circulating triglyceride level   IAGP   5509061   MGI PMID:17465682 increased circulating triglyceride level   IAGP   5509061   MGI PMID:12453895 increased circulating triglyceride level   IAGP   5509061   MGI PMID:17003330 increased circulating triglyceride level   IAGP   5509061   MGI PMID:8177042 increased circulating triglyceride level   IAGP   5509061   MGI PMID:16394172 increased circulating triglyceride level   IAGP   5509061   MGI PMID:11445560 increased circulating VLDL cholesterol level   IAGP   5509061   MGI PMID:8177042 increased circulating VLDL cholesterol level   IAGP   5509061   MGI PMID:15319454 increased defecation   IAGP   5509061   MGI PMID:21151569 increased eating behavior   IAGP   5509061   MGI PMID:21151569 increased fat cell size   IAGP   5509061   MGI PMID:1013161 increased fat cell size   IAGP   5509061   MGI PMID:22958920 increased fat cell size   IAGP   5509061   MGI PMID:16879220 increased fat cell size   IAGP   5509061   MGI PMID:6393185 increased fatty acid level   IAGP   5509061   MGI PMID:16804058 increased fluid intake   IAGP   5509061   MGI PMID:17465682 increased food intake   IAGP   5509061   MGI PMID:12897241 increased food intake   IAGP   5509061   MGI PMID:15064421 increased food intake   IAGP   5509061   MGI PMID:16469807 increased glycogen level   IAGP   5509061   MGI PMID:15319454 increased growth rate   IAGP   5509061   MGI PMID:4588246 increased growth rate   IAGP   5509061   MGI PMID:14824537 increased heart weight   IAGP   5509061   MGI PMID:16246967 increased heart weight   IAGP   5509061   MGI PMID:21151569 increased inguinal fat pad weight   IAGP   5509061   MGI PMID:21151569 increased insulin secretion   IAGP   5509061   MGI PMID:19103808 increased insulin secretion   IAGP   5509061   MGI PMID:17465682 increased insulin sensitivity   IAGP   5509061   MGI PMID:18682832 increased insulin sensitivity   IAGP   5509061   MGI PMID:16804058 increased insulin sensitivity   IAGP   5509061   MGI PMID:12540600 increased interleukin-6 secretion   IAGP   5509061   MGI PMID:17023554 increased interscapular fat pad weight   IAGP   5509061   MGI PMID:7815168 increased kidney weight   IAGP   5509061   MGI PMID:20634301 increased kidney weight   IAGP   5509061   MGI PMID:21151569 increased kidney weight   IAGP   5509061   MGI PMID:12453895 increased lean body mass   IAGP   5509061   MGI PMID:17550780 increased liver cholesterol level   IAGP   5509061   MGI PMID:11445560 increased liver triglyceride level   IAGP   5509061   MGI PMID:22958918 increased liver triglyceride level   IAGP   5509061   MGI PMID:11445560 increased liver weight   IAGP   5509061   MGI PMID:17003330 increased liver weight   IAGP   5509061   MGI PMID:21151569 increased liver weight   IAGP   5509061   MGI PMID:12000791 increased liver weight   IAGP   5509061   MGI PMID:12453895 increased macrophage cell number   IAGP   5509061   MGI PMID:21151569 increased metastatic potential   IAGP   5509061   MGI PMID:16998795 increased oxygen consumption   IAGP   5509061   MGI PMID:12897241 increased oxygen consumption   IAGP   5509061   MGI PMID:16469807 increased oxygen consumption   IAGP   5509061   MGI PMID:7815168 increased pancreas weight   IAGP   5509061   MGI PMID:12453895 increased pancreatic alpha cell number   IAGP   5509061   MGI PMID:19289822 increased pancreatic beta cell mass   IAGP   5509061   MGI PMID:6393185 increased pancreatic beta cell number   IAGP   5509061   MGI PMID:12136396 increased pancreatic beta cell number   IAGP   5509061   MGI PMID:6393185 increased pancreatic islet number   IAGP   5509061   MGI PMID:17465682 increased percent body fat   IAGP   5509061   MGI PMID:17482547 increased percent body fat   IAGP   5509061   MGI PMID:17465682 increased percent body fat   IAGP   5509061   MGI PMID:17550780 increased renal glomerulus basement membrane thickness   IAGP   5509061   MGI PMID:20634301 increased seminal vesicle weight   IAGP   5509061   MGI PMID:12000791 increased sensitivity to induced morbidity/mortality   IAGP   5509061   MGI PMID:22232663 increased susceptibility to endotoxin shock   IAGP   5509061   MGI PMID:17023554 increased susceptibility to weight gain   IAGP   5509061   MGI PMID:12000791 increased thermal nociceptive threshold   IAGP   5509061   MGI PMID:17130477 increased total body fat amount   IAGP   5509061   MGI PMID:14978271 increased total body fat amount   IAGP   5509061   MGI PMID:21151569 increased total fat pad weight   IAGP   5509061   MGI PMID:9623983 increased triglyceride level   IAGP   5509061   MGI PMID:12244109 increased triglyceride level   IAGP   5509061   MGI PMID:12126735 increased urine glucose level   IAGP   5509061   MGI PMID:22958918 increased urine glucose level   IAGP   5509061   MGI PMID:17465682 increased urine glucose level   IAGP   5509061   MGI PMID:4588246 increased white adipose tissue amount   IAGP   5509061   MGI PMID:16804058 increased white adipose tissue amount   IAGP   5509061   MGI PMID:21151569 increased white adipose tissue amount   IAGP   5509061   MGI PMID:12000791 increased white fat cell number   IAGP   5509061   MGI PMID:21151569 increased white fat cell size   IAGP   5509061   MGI PMID:21151569 infertility   IAGP   5509061   MGI PMID:21151569 infertility   IAGP   5509061   MGI PMID:6393185 insulin resistance   IAGP   5509061   MGI PMID:22958918 insulin resistance   IAGP   5509061   MGI PMID:21151569 insulin resistance   IAGP   5509061   MGI PMID:17465682 insulin resistance   IAGP   5509061   MGI PMID:17003330 insulin resistance   IAGP   5509061   MGI PMID:15319454 insulin resistance   IAGP   5509061   MGI PMID:16394172 liver inflammation   IAGP   5509061   MGI PMID:17023554 lung inflammation   IAGP   5509061   MGI PMID:16373670 male infertility   IAGP   5509061   MGI PMID:12000791 male infertility   IAGP   5509061   MGI PMID:6393185 male infertility   IAGP   5509061   MGI PMID:12453895 mesangiolysis   IAGP   5509061   MGI PMID:20634301 obese   IAGP   5509061   MGI PMID:15201286 obese   IAGP   5509061   MGI PMID:21151569 obese   IAGP   5509061   MGI PMID:19917283 obese   IAGP   5509061   MGI PMID:14978271 obese   IAGP   5509061   MGI PMID:12540600 obese   IAGP   5509061   MGI PMID:12925742 obese   IAGP   5509061   MGI PMID:16394172 obese   IAGP   5509061   MGI PMID:12885755 obese   IAGP   5509061   MGI PMID:12136396 obese   IAGP   5509061   MGI PMID:9623983 osteopetrosis   IAGP   5509061   MGI PMID:10660043 oxidative stress   IAGP   5509061   MGI PMID:17465682 pale liver   IAGP   5509061   MGI PMID:21151569 pancreatic islet hyperplasia   IAGP   5509061   MGI PMID:11078464 polydipsia   IAGP   5509061   MGI PMID:19289822 polyphagia   IAGP   5509061   MGI PMID:9623983 polyphagia   IAGP   5509061   MGI PMID:6393185 polyphagia   IAGP   5509061   MGI PMID:17465682 polyphagia   IAGP   5509061   MGI PMID:12453895 polyphagia   IAGP   5509061   MGI PMID:17003330 polyphagia   IAGP   5509061   MGI PMID:12244109 polyphagia   IAGP   5509061   MGI PMID:17550780 polyuria   IAGP   5509061   MGI PMID:4588246 polyuria   IAGP   5509061   MGI PMID:19289822 polyuria   IAGP   5509061   MGI PMID:21151569 premature death   IAGP   5509061   MGI PMID:4588246 prolonged diestrus   IAGP   5509061   MGI PMID:12000791 prolonged estrous cycle   IAGP   5509061   MGI PMID:12000791 prolonged estrus   IAGP   5509061   MGI PMID:12000791 reduced female fertility   IAGP   5509061   MGI PMID:17550780 reduced male fertility   IAGP   5509061   MGI PMID:22232663 reduced male fertility   IAGP   5509061   MGI PMID:6393185 reduced nerve conduction velocity   IAGP   5509061   MGI PMID:17130477 renal glomerulus hypertrophy   IAGP   5509061   MGI PMID:20634301 renal interstitial fibrosis   IAGP   5509061   MGI PMID:20634301 short femur   IAGP   5509061   MGI PMID:16039170 short humerus   IAGP   5509061   MGI PMID:16039170 small liver   IAGP   5509061   MGI PMID:16804058 small pancreatic islets   IAGP   5509061   MGI PMID:4588246 weight loss   IAGP   5509061   MGI PMID:22232663 weight loss   IAGP   5509061   MGI PMID:16469807 white spotting   IAGP   5509061   MGI PMID:19917283 Disease Annotations Asthma  (ISS) Body Weight Changes  (ISS) Brain Injuries  (ISS) Carcinoma, Non-Small-Cell Lung  (ISS) Carcinoma, Renal Cell  (ISS) Cystic Fibrosis  (ISS) Diabetes Mellitus, Experimental  (IPM,ISS) Diabetes Mellitus, Type 2  (ISS) Diabetes, Gestational  (ISS) Diabetic Nephropathies  (IAGP) Fatty Liver  (ISS) Femoral Fractures  (ISS) Fetal Growth Retardation  (ISS) Heart Failure  (IPM) Huntington Disease  (ISS) Hypercapnia  (ISS) Hypertension  (ISS) Hypoventilation  (ISS) Insulin Resistance  (ISS) Kidney Reperfusion Injury  (ISS) Liver Cirrhosis, Experimental  (IPM,ISS) Lung Diseases  (IED) Metabolic Syndrome X  (ISS) Myocardial Reperfusion Injury  (ISS) Obesity  (IPM,ISS) Osteoporosis  (ISS) Pneumonia, Bacterial  (IPM) Pneumonia, Pneumococcal  (IPM) Pre-Eclampsia  (ISS) Pulmonary Disease, Chronic Obstructive  (ISS) Reperfusion Injury  (ISS) Rhinitis  (ISS) Sepsis  (ISS) Short Bowel Syndrome  (ISS) Sleep Apnea, Obstructive  (ISS) Spinal Cord Injuries  (ISS) Gene-Chemical Interaction Annotations (R)-lipoic acid  (EXP,ISO) (R)-mevalonic acid  (EXP) 17beta-estradiol  (EXP) 17beta-hydroxy-5alpha-androstan-3-one  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,6-di-tert-butyl-4-methylphenol  (EXP) 2-amino-2-deoxy-D-galactopyranose  (EXP) 2-deoxy-D-glucose  (ISO) 2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP) 3',5'-cyclic AMP  (ISO) 3,4-methylenedioxymethamphetamine  (ISO) 3-chloropropane-1,2-diol  (ISO) 3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO) 4-hydroxybenzoic acid  (ISO) 5-aza-2'-deoxycytidine  (ISO) 9-cis-retinoic acid  (ISO) AACOCF3  (EXP) acarbose  (ISO) acetaldehyde  (EXP) acetylsalicylic acid  (ISO) actinomycin D  (ISO) aldehydo-D-glucosamine 6-phosphate  (EXP) all-trans-retinol  (ISO) amlodipine  (ISO) ammonium chloride  (ISO) anandamide  (ISO) apigenin  (EXP) apocynin  (EXP) arachidonic acid  (EXP) arsenic atom  (ISO) aspartame  (ISO) ATP  (ISO) bezafibrate  (EXP,ISO) bis(2-ethylhexyl) phthalate  (EXP) bisphenol A  (EXP) bucladesine  (EXP) calcitriol  (EXP) calcium atom  (EXP,ISO) calcium(0)  (EXP,ISO) candesartan  (ISO) capsaicin  (EXP,ISO) CCCP  (ISO) cerulenin  (EXP) chlorpromazine  (ISO) chromium atom  (ISO) clofibrate  (EXP,ISO) clozapine  (ISO) cobalt dichloride  (EXP,ISO) D-glucose  (ISO) DDE  (EXP) desferrioxamine B  (ISO) dexamethasone  (EXP,ISO) dextran sulfate  (EXP) diazoxide  (ISO) diethylstilbestrol  (EXP) dioxygen  (EXP,ISO) dipyridamole  (ISO) disodium selenite  (EXP) dobutamine  (EXP,ISO) DPCPX  (ISO) elemental selenium  (ISO) enalapril  (EXP) ethanol  (ISO) fenoterol  (ISO) flufenamic acid  (EXP) fonofos  (ISO) fructose  (ISO) gamma-hexachlorocyclohexane  (ISO) genistein  (EXP,ISO) glucose  (ISO) hydrogen peroxide  (ISO) indinavir  (EXP,ISO) indomethacin  (ISO) isoprenaline  (ISO) kainic acid  (EXP) lamivudine  (EXP) lanthanum atom  (EXP) lipoic acid  (EXP,ISO) loganin  (EXP) LY294002  (EXP) manganese atom  (ISO) manganese(0)  (ISO) melatonin  (ISO) menadione  (ISO) mercury dichloride  (EXP) metformin  (EXP) methadone  (ISO) methotrexate  (EXP) mevalonic acid  (EXP) monocrotaline  (EXP) N-methyl-N-nitrosurea  (EXP) N-nitrosodimethylamine  (ISO) naproxen  (ISO) nevirapine  (ISO) nickel dichloride  (ISO) nickel sulfate  (ISO) nicotinic acid  (EXP,ISO) nitric oxide  (ISO) olanzapine  (ISO) oleanolic acid  (EXP) oleic acid  (EXP) ozone  (EXP) paracetamol  (EXP) paraquat  (ISO) parathion  (ISO) perindopril  (ISO) phencyclidine  (EXP) phenobarbital  (ISO) pioglitazone  (ISO) pirinixic acid  (EXP) pitavastatin  (EXP) pravastatin  (EXP) progesterone  (EXP,ISO) propranolol  (ISO) propylparaben  (EXP,ISO) prostaglandin E2  (ISO) pyruvic acid  (ISO) quercetin  (EXP) ramipril  (ISO) reserpine  (EXP) resveratrol  (ISO) rosiglitazone  (EXP,ISO) rotenone  (ISO) roxarsone  (ISO) S-adenosyl-L-methionine  (ISO) saquinavir  (EXP) selenium atom  (ISO) simvastatin  (EXP) stavudine  (ISO) sumatriptan  (ISO) superoxide  (EXP,ISO) terbufos  (ISO) terbutaline  (EXP) tetrachloromethane  (EXP,ISO) thioacetamide  (EXP,ISO) trans-resveratrol  (ISO) trichostatin A  (ISO) troglitazone  (EXP,ISO) ursolic acid  (EXP) vanadium atom  (ISO) vanadium(0)  (ISO) wortmannin  (EXP) zidovudine  (EXP,ISO) zinc atom  (ISO) zinc dichloride  (ISO) zinc sulfate  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process adipose tissue development  (IGI) adult feeding behavior  (IDA) bile acid metabolic process  (IDA) bone mineralization involved in bone maturation  (ISO) cardiac muscle hypertrophy  (ISO) central nervous system neuron development  (IMP) cholesterol metabolic process  (IGI) eating behavior  (IGI) energy reserve metabolic process  (ISO) fatty acid catabolic process  (ISO) glucose metabolic process  (IMP) glycerol biosynthetic process  (ISO) hormone metabolic process  (IMP) insulin secretion  (IGI) intracellular signal transduction  (ISO) leptin-mediated signaling pathway  (ISO) leukocyte tethering or rolling  (ISO) lipid metabolic process  (IMP) negative regulation of apoptotic process  (ISO) negative regulation of appetite  (IDA) negative regulation of cartilage development  (ISO) negative regulation of glucagon secretion  (IDA) negative regulation of glutamine transport  (ISO) negative regulation of metabolic process  (ISO) negative regulation of transcription from RNA polymerase II promoter  (IDA) negative regulation of vasoconstriction  (ISO) ovulation from ovarian follicle  (ISO) placenta development  (ISO) positive regulation of cell proliferation  (ISO) positive regulation of developmental growth  (ISO) positive regulation of hepatic stellate cell activation  (ISO) positive regulation of insulin receptor signaling pathway  (ISO) positive regulation of ion transport  (ISO) positive regulation of JAK-STAT cascade  (IDA,ISO) positive regulation of MAPK cascade  (ISO) positive regulation of myeloid cell differentiation  (IDA) positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO) positive regulation of protein import into nucleus  (IDA) positive regulation of reactive oxygen species metabolic process  (ISO) positive regulation of STAT protein import into nucleus  (IDA) positive regulation of tyrosine phosphorylation of Stat3 protein  (ISO) regulation of blood pressure  (ISO) regulation of fat cell differentiation  (IGI) regulation of gluconeogenesis  (IMP) regulation of insulin secretion  (IMP) regulation of intestinal cholesterol absorption  (IDA) regulation of lipoprotein lipid oxidation  (ISO) regulation of metabolic process  (IMP) regulation of protein phosphorylation  (IDA) regulation of steroid biosynthetic process  (IMP) response to dietary excess  (IGI,IMP,ISO) response to insulin stimulus  (IMP) signal transduction  (IEA) tyrosine phosphorylation of STAT protein  (IDA) Cellular Component extracellular region  (IEA) extracellular space  (IDA,ISO) Molecular Function growth factor activity  (IDA) hormone activity  (ISO) peptide hormone receptor binding  (ISO) protein binding  (IPI) Molecular Pathway Annotations energy homeostasis pathway  (TAS) hypoxia inducible factor pathway  (ISO) Jak-Stat signaling pathway  (IEA) leptin system pathway  (TAS) External Database Links KEGG Pathway Adipocytokine signaling pathway Cytokine-cytokine receptor interaction Jak-STAT signaling pathway Neuroactive ligand-receptor interaction Pathway Interaction Database HIF-1-alpha transcription factor network (PID:200202) Signaling events mediated by PTP1B (PID:200042) Phenotype Annotations abnormal acute inflammation  (IAGP) abnormal adipocyte glucose uptake  (IAGP) abnormal adipose tissue amount  (IAGP) abnormal adipose tissue morphology  (IAGP) abnormal arteriole morphology  (IAGP) abnormal behavior  (IAGP) abnormal body size  (IAGP) abnormal body temperature  (IAGP) abnormal body weight  (IAGP) abnormal bone marrow morphology  (IAGP) abnormal branching of the mammary ductal tree  (IAGP) abnormal cardiovascular system physiology  (IAGP) abnormal chemokine secretion  (IAGP) abnormal circulating cholesterol level  (IAGP) abnormal circulating corticosterone level  (IAGP) abnormal circulating glucose level  (IAGP) abnormal circulating hormone level  (IAGP) abnormal circulating insulin level  (IAGP) abnormal circulating pancreatic peptide level  (IAGP) abnormal circulating testosterone level  (IAGP) abnormal cortical plate morphology  (IAGP) abnormal corticosterone level  (IEA) abnormal digestive system physiology  (IAGP) abnormal embryonic neuroepithelium morphology  (IAGP) abnormal energy expenditure  (IAGP) abnormal enzyme/ coenzyme level  (IAGP) abnormal epidermal layer morphology  (IAGP) abnormal epididymal fat pad morphology  (IAGP) abnormal estrous cycle  (IAGP) abnormal excitatory postsynaptic currents  (IAGP) abnormal fat cell morphology  (IAGP) abnormal fat pad morphology  (IAGP) abnormal fatty acid beta-oxidation  (IAGP) abnormal fatty acid level  (IAGP) abnormal fertility/fecundity  (IAGP) abnormal food intake  (IAGP) abnormal frequency of paradoxical sleep  (IAGP) abnormal gland physiology  (IAGP) abnormal gluconeogenesis  (IAGP) abnormal glucose homeostasis  (IAGP) abnormal glucose tolerance  (IAGP) abnormal glycogen homeostasis  (IAGP) abnormal gonadal fat pad morphology  (IAGP) abnormal hormone level  (IAGP) abnormal inhibitory postsynaptic currents  (IAGP) abnormal insulin secretion  (IAGP) abnormal interstitial cell of Cajal morphology  (IAGP) abnormal intestinal epithelium morphology  (IAGP) abnormal intestinal goblet cell morphology  (IAGP) abnormal intestinal mucosa morphology  (IAGP) abnormal intestine morphology  (IAGP) abnormal Leydig cell morphology  (IAGP) abnormal lipid homeostasis  (IAGP) abnormal lipid level  (IAGP) abnormal liver morphology  (IAGP) abnormal liver size  (IAGP) abnormal liver weight  (IAGP) abnormal locomotor behavior  (IAGP) abnormal long bone epiphyseal plate morphology  (IAGP) abnormal long bone epiphyseal plate proliferative zone  (IAGP) abnormal long bone hypertrophic chondrocyte zone  (IAGP) abnormal maternal nurturing  (IAGP) abnormal metabolism  (IAGP) abnormal microglial cell physiology  (IAGP) abnormal muscle cell glucose uptake  (IAGP) abnormal muscle contractility  (IAGP) abnormal muscle morphology  (IAGP) abnormal myocardial fiber morphology  (IAGP) abnormal myocardial fiber physiology  (IAGP) abnormal neuron morphology  (IAGP) abnormal osteoclast differentiation  (IAGP) abnormal ovarian follicle morphology  (IAGP) abnormal ovarian folliculogenesis  (IAGP) abnormal oxygen consumption  (IAGP) abnormal pain threshold  (IAGP) abnormal pancreatic beta cell morphology  (IAGP) abnormal pancreatic beta cell physiology  (IAGP) abnormal pancreatic islet morphology  (IAGP) abnormal podocyte morphology  (IAGP) abnormal postnatal growth  (IAGP) abnormal protein level  (IAGP) abnormal respiratory electron transport chain  (IAGP) abnormal retinal vasculature morphology  (IAGP) abnormal skeletal muscle fiber type ratio  (IAGP) abnormal skeletal muscle morphology  (IAGP) abnormal skeleton development  (IAGP) abnormal sleep pattern  (IAGP) abnormal sperm number  (IAGP) abnormal sympathetic nervous system physiology  (IAGP) abnormal tumor necrosis factor level  (IAGP) abnormal urine catecholamine level  (IAGP) abnormal urine homeostasis  (IAGP) abnormal vagina orifice morphology  (IAGP) abnormal vascular wound healing  (IAGP) abnormal white adipose tissue amount  (IAGP) absent corpus luteum  (IAGP) albuminuria  (IAGP) allodynia  (IAGP) atherosclerotic lesions  (IAGP) decreased activity of thyroid  (IAGP) decreased adiponectin level  (IAGP) decreased body length  (IAGP) decreased body size  (IAGP) decreased body temperature  (IAGP) decreased body weight  (IAGP) decreased bone mass  (IAGP) decreased cardiac muscle contractility  (IAGP) decreased CD4-positive T cell number  (IAGP) decreased circulating cholesterol level  (IAGP) decreased circulating corticosterone level  (IAGP) decreased circulating free fatty acid level  (IAGP) decreased circulating glucose level  (IAGP) decreased circulating HDL cholesterol level  (IAGP) decreased circulating insulin level  (IAGP) decreased circulating LDL cholesterol level  (IAGP) decreased circulating testosterone level  (IAGP) decreased circulating triglyceride level  (IAGP) decreased circulating tumor necrosis factor level  (IAGP) decreased core body temperature  (IAGP) decreased eating behavior  (IAGP) decreased epididymal fat pad weight  (IAGP) decreased fat cell size  (IAGP) decreased food intake  (IAGP) decreased gonadal fat pad weight  (IAGP) decreased inguinal fat pad weight  (IAGP) decreased insulin secretion  (IAGP) decreased lean body mass  (IAGP) decreased length of long bones  (IAGP) decreased liver cholesterol level  (IAGP) decreased liver triglyceride level  (IAGP) decreased liver weight  (IAGP) decreased mesenteric fat pad weight  (IAGP) decreased neuron number  (IAGP) decreased NK cell number  (IAGP) decreased oxygen consumption  (IAGP) decreased pancreatic beta cell mass  (IAGP) decreased pancreatic beta cell number  (IAGP) decreased respiratory quotient  (IAGP) decreased retroperitoneal fat pad weight  (IAGP) decreased seminal vesicle weight  (IAGP) decreased skeletal muscle fiber size  (IAGP) decreased skeletal muscle mass  (IAGP) decreased splenocyte number  (IAGP) decreased susceptibility to diet-induced obesity  (IAGP) decreased susceptibility to hepatic steatosis  (IAGP) decreased T cell proliferation  (IAGP) decreased testis weight  (IAGP) decreased total body fat amount  (IAGP) decreased triglyceride level  (IAGP) disorganized pancreatic islets  (IAGP) enhanced fertility  (IAGP) enlarged kidney  (IAGP) enlarged myocardial fiber  (IAGP) enlarged pancreatic islets  (IAGP) expanded mesangial matrix  (IAGP) female infertility  (IAGP) fragmentation of sleep/wake states  (IAGP) glomerulosclerosis  (IAGP) heart left ventricle hypertrophy  (IAGP) hepatic steatosis  (IAGP) hyperalgesia  (IAGP) hyperglycemia  (IAGP) hyperlipidemia  (IAGP) hypersecretion of corticosterone  (IAGP) hypoactivity  (IAGP) hypoglycemia  (IAGP) hypotension  (IAGP) impaired adaptive thermogenesis  (IAGP) impaired glucose tolerance  (IAGP) improved glucose tolerance  (IAGP) increased adrenocorticotropin level  (IAGP) increased blood urea nitrogen level  (IAGP) increased body length  (IAGP) increased body weight  (IAGP) increased bone mass  (IAGP) increased brown adipose tissue amount  (IAGP) increased brown fat cell lipid droplet size  (IAGP) increased cholesterol level  (IAGP) increased circulating cholesterol level  (IAGP) increased circulating corticosterone level  (IAGP) increased circulating free fatty acid level  (IAGP) increased circulating glucose level  (IAGP) increased circulating HDL cholesterol level  (IAGP) increased circulating insulin level  (IAGP) increased circulating LDL cholesterol level  (IAGP) increased circulating leptin level  (IAGP) increased circulating triglyceride level  (IAGP) increased circulating VLDL cholesterol level  (IAGP) increased defecation  (IAGP) increased eating behavior  (IAGP) increased fat cell size  (IAGP) increased fatty acid level  (IAGP) increased fluid intake  (IAGP) increased food intake  (IAGP) increased glycogen level  (IAGP) increased growth rate  (IAGP) increased heart weight  (IAGP) increased inguinal fat pad weight  (IAGP) increased insulin secretion  (IAGP) increased insulin sensitivity  (IAGP) increased interleukin-6 secretion  (IAGP) increased interscapular fat pad weight  (IAGP) increased kidney weight  (IAGP) increased lean body mass  (IAGP) increased liver cholesterol level  (IAGP) increased liver triglyceride level  (IAGP) increased liver weight  (IAGP) increased macrophage cell number  (IAGP) increased metastatic potential  (IAGP) increased oxygen consumption  (IAGP) increased pancreas weight  (IAGP) increased pancreatic alpha cell number  (IAGP) increased pancreatic beta cell mass  (IAGP) increased pancreatic beta cell number  (IAGP) increased pancreatic islet number  (IAGP) increased percent body fat  (IAGP) increased renal glomerulus basement membrane thickness  (IAGP) increased seminal vesicle weight  (IAGP) increased sensitivity to induced morbidity/mortality  (IAGP) increased susceptibility to endotoxin shock  (IAGP) increased susceptibility to weight gain  (IAGP) increased thermal nociceptive threshold  (IAGP) increased total body fat amount  (IAGP) increased total fat pad weight  (IAGP) increased triglyceride level  (IAGP) increased urine glucose level  (IAGP) increased white adipose tissue amount  (IAGP) increased white fat cell number  (IAGP) increased white fat cell size  (IAGP) infertility  (IAGP) insulin resistance  (IAGP) liver inflammation  (IAGP) lung inflammation  (IAGP) male infertility  (IAGP) mesangiolysis  (IAGP) obese  (IAGP) osteopetrosis  (IAGP) oxidative stress  (IAGP) pale liver  (IAGP) pancreatic islet hyperplasia  (IAGP) polydipsia  (IAGP) polyphagia  (IAGP) polyuria  (IAGP) premature death  (IAGP) prolonged diestrus  (IAGP) prolonged estrous cycle  (IAGP) prolonged estrus  (IAGP) reduced female fertility  (IAGP) reduced male fertility  (IAGP) reduced nerve conduction velocity  (IAGP) renal glomerulus hypertrophy  (IAGP) renal interstitial fibrosis  (IAGP) short femur  (IAGP) short humerus  (IAGP) small liver  (IAGP) small pancreatic islets  (IAGP) weight loss  (IAGP) white spotting  (IAGP) References - curated 1. 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18984739   18996960   19008231   19017730   19020034   19020099   19023096   19025999   19036876   19038858   19041763   19049975   19052259   19066318   19074282   19074983   19095090   19100295   19103304   19103808   19107190   19114551   19114642   19117545   19117547   19136651   19136654   19136718   19139561   19156541   19156569   19179437   19188425   19188430   19193947   19204053   19211925   19214223   19219422   19223399   19233863   19254572   19286646   19289822   19338759   19356715   19373220   19390091   19401184   19401420   19408668   19409880   19433254   19435851   19436734   19457101   19460359   19468077   19478204   19490910   19491194   19491239   19494115   19502550   19505930   19509029   19513120   19528970   19531256   19535678   19576209   19589781   19619509   19620723   19622746   19628573   19633656   19633657   19636528   19651818   19656487   19675137   19688337   19706524   19706786   19730740   19737523   19738035   19749180   19751733   19752026   19773811   19790050   19808894   19828684   19834009   19838201   19840239   19850873   19864403   19875640   19883618   19885945   19887048   19888448   19898815   19917283   19929143   19940178   19955656   19961738   19966187   19996103   20007767   20032483   20060009   20068132   20068135   20074524   20074527   20097762   20100487   20103702   20107083   20122948   20157577   20164094   20185765   20200319   20200981   20223942   20227394   20231468   20348926   20354157   20363835   20364085   20368432   20371609   20410123   20413511   20424269   20427662   20445103   20447400   20448152   20488786   20501669   20506495   20522600   20532036   20534724   20538900   20592471   20595619   20601111   20603014   20613882   20616094   20624962   20627936   20634301   20634488   20649970   20660304   20660733   20664173   20702576   20707912   20727362   20739548   20798332   20807840   20808781   20808936   20813965   20824498   20842343   20851881   20851886   20876580   20881244   20926971   20929976   20929977   20952387   20953578   20967535   21031339   21035758   21056997   21062956   21068004   21078910   21084751   21086065   21109190   21109192   21119198   21123564   21134353   21135134   21139688   21145759   21151569   21169216   21183787   21187319   21209012   21209019   21216976   21233451   21234744   212501   21266330   21267068   21270263   21278136   21285316   21289197   21298050   21325051   21325106   21325649   21334313   21338489   21356196   21382979   21386087   21427219   21427359   21427410   21436399   21437243   21441440   21444625   21459326   21464907   21520064   21520275   21521746   21532591   21533112   21550356   21555864   21557698   21572010   21576825   21593203   21606595   21616110   21623172   21640075   21669879   21670064   21673305   21704006   21731759   21737754   21743466   21745644   21804540   21852673   21853117   21856284   21865462   21885868   21892182   21900603   21907142   21908604   21911492   21933985   21949859   21954068   21969596   21971349   21978495   21997794   21998599   22000926   22009939   22037453   22037645   22037765   22042484   22051061   22067317   22075916   22078933   22080103   22083962   22094601   22095235   22135239   22144677   22152304   22160191   22166979   22167524   22187378   22197240   22201680   22202803   22205566   22207628   22210924   22225875   22227600   22232663   22253420   22253718   22259190   22268099   22275362   22279186   22287654   22291185   22310664   223169   22326225   22326952   22326958   22327204   22328591   22341640   22345430   22381575   22383686   22395110   22396530   22405860   22427681   22434078   22466652   22493092   22503562   22504909   22522563   22535963   22541436   22570438   22581287   22581458   22610169   22621923   22628617   22647282   22669248   22682244   22692856   22699504   22700774   22703581   22719268   22722451   22722857   22759970   22761160   22768838   22815920   22829877   22833425   22841822   22848520   22849606   22868909   22904304   22927639   22958918   22958920   22969086   22975078   22993381   23024263   23024365   23028821   23040070   23064363   23071089   23099119   23115649   23117929   23149622   23149942   23178931   23185367   23201226   23220275   23248313   23274884   23312282   23417423   2912985   3044893   350680   3976886   4588246   4767369   5059196   508700   5412353   565045   6393185   6971254   7053993   7075918   7485473   7487925   7490107   7499416   7508208   7560100   7564879   7566150   7568067   7584987   7593267   7593268   760211   7608151   7616850   7624352   7624777   7624778   7635205   7651535   7661115   7669033   7706460   7733267   7735347   7784267   7800681   7815168   7824540   7835283   7876925   7876929   7889367   7891022   7906968   7914350   7928642   7968588   7984236   7985012   7987248   8023896   8089731   8145074   8150231   8166263   8177042   8177043   8200619   8253133   834144   8344641   8348338   8349816   8360782   8371149   8386184   8392795   840297   8467860   8498501   8559786   8566229   8570651   8576190   8589726   8597582   8603777   8609847   8614460   8621378   8621612   8621615   8622953   8625929   8632796   8633022   8643634   8643697   8645274   8647948   8650171   8653144   8661738   8661739   8662239   8663251   8680474   8687445   8687512   8729088   8760093   8782827   8817099   8856397   8856925   8866547   8886745   8898192   8920957   8939859   8962136   8965809   8973143   8974400   8990120   8996253   9002984   9007565   9011250   9013734   9013739   9022071   9027475   9036533   9037192   9054925   9090387   9099705   9102398   9119224   9133562   9139806   9166685   9173544   9177239   9177786   9192391   9200670   9202206   9207125   9225721   9231663   9245710   9249548   9254055   9271234   9275075   9276726   9276734   9278578   9294198   9299448   9305858   9311966   9345027   9367912   9374468   9374549   9380761   9388507   9389733   9389736   9389742   9389752   9392508   9398609   9399964   9405382   9421367   9421392   9421394   9438411   9447943   9464852   9486972   9500540   9504329   9509396   9511737   9517901   9519731   9559948   9564880   9568684   9575960   9575979   9590691   9618302   9623983   9627357   9636194   9654348   9660946   9726234   9732873   9748302   9751754   9763877   9826672   9826706   9832419   9868202   9874578   9885188   9886818   9886838   9887187   9892232   9892692   9916873   9924185   9927300   9927310   9933608   9934817   9950766   9950797 RGD Disease Portals Lep has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cancer Phenotypes Biological Process Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Biological Process Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Biological Process Neurological Diseases Neurological Pathways Neurological Phenotypes Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Biological Process Respiratory Diseases Respiratory Pathways Respiratory Phenotypes Genomics Comparative Map Data Lep   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,060,221 - 29,073,876 + NCBI Mouse cM Map 6 12.3   NCBI Mouse Celera Assembly 6 29,063,769 - 29,077,429 + NCBI Mouse Genome Assembly Build 37 6 29,010,221 - 29,023,876 + NCBI Mouse Genome Assembly Build 36.1 6 29,010,221 - 29,023,876 + NCBI Mouse Cytogenetic Map 6 A3.3   NCBI LEP   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 7 131,224,516 - 131,240,864 + NCBI Human Alternate Assembly CRA_TCAGchr7v2 7 127,264,455 - 127,280,803 + NCBI Human Genome Assembly HuRef 7 122,242,298 - 122,258,647 + NCBI Human Genome Assembly GRCh37 7 127,881,331 - 127,897,682 + NCBI Human Genome Assembly Build 36 7 127,668,567 - 127,684,917 + NCBI Human Cytogenetic Map 7 q31.3   NCBI Human Genome Assembly 7 127,475,281 - 127,491,632   NCBI Lep   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 4 q22   NCBI RGSC Genome Assembly v5.0 4 56,085,079 - 56,099,209 + NCBI RGSC Genome Assembly v3.4 4 55,943,837 - 55,945,938 + NCBI Rat Celera Assembly 4 52,770,132 - 52,784,148 + NCBI Genome Assembly 3.1 4 56,185,364 - 56,197,221 + NCBI RH 3.4 4 309.5   RGD Position Markers PMC187774P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,070,970 - 29,071,082   UniSTS Mouse Celera Assembly 6 29,074,523 - 29,074,635   UniSTS Mouse Genome Assembly Build 37 6 29,020,970 - 29,021,082   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS PMC23608P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,070,959 - 29,071,100   UniSTS Mouse Celera Assembly 6 29,074,512 - 29,074,653   UniSTS Mouse Genome Assembly Build 37 6 29,020,959 - 29,021,100   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS PMC316374P2   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,059,370 - 29,060,180   UniSTS Mouse Celera Assembly 6 29,062,918 - 29,063,728   UniSTS Mouse Genome Assembly Build 37 6 29,009,370 - 29,010,180   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS Lep   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,070,887 - 29,071,077   UniSTS Mouse cM Map 6 10.5   UniSTS Mouse Celera Assembly 6 29,074,440 - 29,074,630   UniSTS Mouse Genome Assembly Build 37 6 29,020,887 - 29,021,077   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS Lep   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,070,975 - 29,071,075   UniSTS Mouse cM Map 6 10.5   UniSTS Mouse Celera Assembly 6 29,074,528 - 29,074,628   UniSTS Mouse Genome Assembly Build 37 6 29,020,975 - 29,021,075   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS Lep   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,070,975 - 29,071,075   UniSTS Mouse cM Map 6 10.5   UniSTS Mouse Celera Assembly 6 29,074,528 - 29,074,628   UniSTS Mouse Genome Assembly Build 37 6 29,020,975 - 29,021,075   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS Lep   Map Chr Position Strand Source Mouse cM Map 6 10.5   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS Lep   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,073,189 - 29,073,394   UniSTS Mouse cM Map 6 10.5   UniSTS Mouse Celera Assembly 6 29,076,742 - 29,076,947   UniSTS Mouse Genome Assembly Build 37 6 29,023,189 - 29,023,394   UniSTS Mouse Cytogenetic Map 6 A3.3   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1302024 Skull7_m skull morphology 7 (mouse) Not determined 6 1 32094496 Mouse 1301131 Chol2_m cholesterol 2 (mouse) Not determined 6 1 32094496 Mouse 1301145 Mob2_m multigenic obesity 2 (mouse) Not determined 6 1 32094496 Mouse 1302168 Imgt1_m impaired glucose tolerance 1 (mouse) Not determined 6 1 32094496 Mouse 5491191 Mobq2_m multigenic obesity QTL 2 (mouse) Not determined 6 1 32094496 Mouse 1558761 Nsila5_m novelty/stress induced locomotor activation 5 (mouse) Not determined 6 1 33619037 Mouse 1357848 Brmth5_m behavioral response to methamphetamines 5 (mouse) Not determined 6 503004 34503097 Mouse 1300731 Smdq3_m segregation of mitochondrial DNA QTL 3 (mouse) Not determined 6 4199207 38199326 Mouse 1302051 Sluc7_m susceptibility to lung cancer 7 (mouse) Not determined 6 9247075 43247169 Mouse 1301137 Cocia8_m cocaine induced activation 8 (mouse) Not determined 6 12701222 46701334 Mouse 1301998 Bts2_m bladder tumor susceptibility 2 (mouse) Not determined 6 12701222 46701334 Mouse 1301850 Fglu_m fasting glucose (mouse) Not determined 6 17684663 51684784 Mouse 1301724 Pcd4ts1_m p-glycoprotein positive CD4 T cell subset 1 (mouse) Not determined 6 17684663 51684784 Mouse 1357748 Grv_m granule cell layer volume (mouse) Not determined 6 27415870 61416015 Mouse 4142062 Wtlr1_m weight loss response 1 (mouse) Not determined 6 28264058 62264180 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_008493 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01052310 (Get FASTA) Search GEO for Microarray Profiles   AC072048 (Get FASTA) Search GEO for Microarray Profiles   AK030984 (Get FASTA) Search GEO for Microarray Profiles   AK142589 (Get FASTA) Search GEO for Microarray Profiles   BC038162 (Get FASTA) Search GEO for Microarray Profiles   BC125245 (Get FASTA) Search GEO for Microarray Profiles   CH466533 (Get FASTA) Search GEO for Microarray Profiles   FJ374142 (Get FASTA) Search GEO for Microarray Profiles   HQ166716 (Get FASTA) Search GEO for Microarray Profiles   U18812 (Get FASTA) Search GEO for Microarray Profiles   U22421 (Get FASTA) Search GEO for Microarray Profiles   U52147 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_008493 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_032519 Peptide Label: precursor Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 6 29,060,221 - 29,073,876 + ENTREZGENE Mouse cM Map 6   + ENTREZGENE Mouse Celera Assembly 6 29,063,769 - 29,077,429 + RGD Mouse Genome Assembly Build 37 6 29,010,221 - 29,023,876 + RGD Protein Sequences Protein RefSeqs NP_032519 (Get FASTA) GenBank Protein AAA64213 (Get FASTA)   AAA64564 (Get FASTA)   AAI25246 (Get FASTA)   ACJ09173 (Get FASTA)   ADM72802 (Get FASTA)   BAC27202 (Get FASTA)   BAE25117 (Get FASTA)   EDL13794 (Get FASTA)   EDL13795 (Get FASTA)   P41160 (Get FASTA) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000059201 ENTREZGENE Ensembl Protein ENSMUSP00000067046 ENTREZGENE Ensembl Transcript ENSMUST00000069789 ENTREZGENE Entrez Gene 16846 ENTREZGENE Gene3D-CATH 4_helix_cytokine_core UniProtKB/Swiss-Prot Germonline ENSMUSG00000059201 HomoloGene Group ID 193 ENTREZGENE InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot   4_helix_cytokine_core UniProtKB/Swiss-Prot   Leptin UniProtKB/Swiss-Prot IPI IPI00111526 UniProtKB/Swiss-Prot   IPI00986712 UniProtKB/TrEMBL KEGG Report mmu:16846 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:104663 ENTREZGENE PANTHER Leptin UniProtKB/Swiss-Prot Pfam Leptin UniProtKB/Swiss-Prot PharmGKB LEP RGD PIRSF Leptin UniProtKB/Swiss-Prot PRINTS LEPTIN UniProtKB/Swiss-Prot ProDom Leptin UniProtKB/Swiss-Prot Superfamily-SCOP 4_helix_cytokine UniProtKB/Swiss-Prot UniGene Mm.277072 ENTREZGENE UniProt E9M0G2_MOUSE UniProtKB/TrEMBL   E9Q7Z0_MOUSE UniProtKB/TrEMBL   LEP_MOUSE UniProtKB/Swiss-Prot   Q544U0_MOUSE UniProtKB/TrEMBL

More on Lep Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 69124 Created: 2001-11-08 Species: Mus musculus Last Modified: 2013-05-14 Status: ACTIVE