Spry3 (sprouty RTK signaling antagonist 3) - Rat Genome Database

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Gene: Spry3 (sprouty RTK signaling antagonist 3) Mus musculus
Analyze
Symbol: Spry3
Name: sprouty RTK signaling antagonist 3
RGD ID: 1614155
MGI Page MGI
Description: Involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of neuron projection arborization. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in brain; head; pancreas; and testis. Orthologous to human SPRY3 (sprouty RTK signaling antagonist 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm1409; Gm391; protein sprouty homolog 3; spro; sprouty homolog 3; sprouty homolog 3 (Drosophila); sprouty3; spry-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic MapX NCBI


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10498682   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11238463   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16339969   PMID:16651541  
PMID:16877379   PMID:20934536   PMID:21062861   PMID:21267068   PMID:21873635   PMID:23074222   PMID:26089202   PMID:27046834   PMID:28027321   PMID:30878395   PMID:31275178   PMID:35297995  
PMID:38466355  


Genomics

Comparative Map Data
Spry3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic MapX NCBI
SPRY3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y56,923,423 - 56,968,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X155,612,586 - 155,782,459 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,612,572 - 155,782,459 (+)EnsemblGRCh38hg38GRCh38
GRCh37Y59,069,571 - 59,115,127 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37X154,842,247 - 155,012,121 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X154,650,645 - 154,665,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 36Y57,509,845 - 57,524,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 34Y57,438,581 - 57,453,248NCBI
CeleraX155,151,125 - 155,165,835 (+)NCBICelera
Cytogenetic MapXq28 and Yq12NCBI
HuRefX143,477,606 - 143,492,323 (+)NCBIHuRef
CHM1_1X154,909,069 - 154,923,770 (+)NCBICHM1_1
T2T-CHM13v2.0Y62,159,112 - 62,204,700 (+)NCBIT2T-CHM13v2.0
T2T-CHM13v2.0X153,837,809 - 154,007,734 (+)NCBIT2T-CHM13v2.0
Spry3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,777,090 - 21,786,280 (+)NCBIGRCr8
mRatBN7.21216,663,188 - 16,673,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,663,389 - 16,672,531 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,500,117 - 17,502,029 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,123,840 - 18,125,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,177,231 - 17,179,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,930,087 - 18,940,622 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,931,477 - 18,940,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,923,714 - 20,933,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,343,080 - 17,344,990 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1218,607,973 - 18,609,883 (+)NCBICelera
Cytogenetic Map12q11NCBI
Spry3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594151,117 - 158,627 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955594151,117 - 158,627 (-)NCBIChiLan1.0ChiLan1.0
SPRY3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,579,315 - 155,743,571 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,582,921 - 155,747,148 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X145,080,299 - 145,239,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X155,125,484 - 155,134,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX155,131,596 - 155,132,462 (+)Ensemblpanpan1.1panPan2
SPRY3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,436,201 - 123,624,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,620,920 - 123,621,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,425,110 - 108,612,073 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,568,537 - 126,761,891 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,568,352 - 126,761,910 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X122,307,070 - 122,494,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,829,781 - 125,016,753 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,560,893 - 124,747,839 (+)NCBIUU_Cfam_GSD_1.0
Spry3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X120,329,720 - 120,451,847 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936958225,179 - 232,564 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936958225,179 - 232,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,754,671 - 125,763,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,744,643 - 125,764,342 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,637,587 - 142,728,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,727,879 - 129,840,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,838,996 - 129,839,862 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,816,067 - 67,935,491 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spry3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624980211,744 - 311,252 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624980209,271 - 311,332 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Markers in Region
UniSTS:224692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,968 - 102,164UniSTSGRCm38
MGSCv37X101,968 - 102,164UniSTSGRCm37
Spry3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM MapUN UniSTS


Expression


Sequence


Protein Domains
SPR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UUD2-F1-model_v2 AlphaFold Q3UUD2 1-288 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1345188 AgrOrtholog
InterPro Sprouty UniProtKB/Swiss-Prot
KEGG Report mmu:236576 UniProtKB/Swiss-Prot
MGD MGI:1345188 ENTREZGENE
NCBI Gene 236576 ENTREZGENE
PANTHER PTHR12365:SF9 UniProtKB/Swiss-Prot
  SPROUTY UniProtKB/Swiss-Prot
Pfam Sprouty UniProtKB/Swiss-Prot
PhenoGen Spry3 PhenoGen
PROSITE SPR UniProtKB/Swiss-Prot
UniProt Q3UUD2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Spry3  sprouty RTK signaling antagonist 3    sprouty homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED