Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | decreases activity | ISO | RGD:70927 | 6480464 | epigallocatechin gallate results in decreased activity of MGST1 protein | CTD | PMID:23010222 | (S)-amphetamine | increases expression | ISO | RGD:70927 | 6480464 | Dextroamphetamine results in increased expression of MGST1 mRNA | CTD | PMID:16715494 | 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | increases expression | EXP | | 6480464 | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of MGST1 mRNA | CTD | PMID:11509743 | 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of MGST1 mRNA | CTD | PMID:11509743 | 1-chloro-2,4-dinitrobenzene | increases expression | ISO | RGD:737343 | 6480464 | Dinitrochlorobenzene results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of MGST1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of MGST1 mRNA | CTD | PMID:16174780 PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:70927 | 6480464 | Ethinyl Estradiol results in decreased expression of MGST1 mRNA | CTD | PMID:12075121 PMID:16174780 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:70927 | 6480464 | Ethinyl Estradiol results in increased expression of MGST1 mRNA | CTD | PMID:17108234 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:70927 | 6480464 | Ethinyl Estradiol results in decreased expression of MGST1 mRNA | CTD | PMID:16174780 PMID:12075121 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MGST1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of MGST1 mRNA | CTD | PMID:17942748 PMID:16174780 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of MGST1 mRNA; more ... | CTD | PMID:11509743 | 17beta-estradiol | decreases expression | ISO | RGD:737343 | 6480464 | Estradiol results in decreased expression of MGST1 mRNA | CTD | PMID:17982697 | 17beta-estradiol | multiple interactions | ISO | RGD:737343 | 6480464 | [Parathion co-treated with Estradiol] results in increased expression of MGST1 mRNA | CTD | PMID:17982697 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of MGST1 mRNA | CTD | PMID:11509743 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:737343 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MGST1 mRNA | CTD | PMID:17101203 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA | CTD | PMID:15034205 PMID:19474220 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:737343 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MGST1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MGST1 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA | CTD | PMID:19474220 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA] | CTD | PMID:16054899 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MGST1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:737343 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA] | CTD | PMID:19474220 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:737343 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MGST1 mRNA | CTD | PMID:21703328 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA; more ... | CTD | PMID:16054899 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of MGST1 mRNA | CTD | PMID:18648102 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:737343 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MGST1 mRNA | CTD | PMID:22079614 | all-trans-retinoic acid | decreases expression | ISO | RGD:737343 | 6480464 | Tretinoin results in decreased expression of MGST1 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | decreases expression | ISO | RGD:70927 | 6480464 | Tretinoin results in decreased expression of MGST1 mRNA | CTD | PMID:20488242 | alpha-hexylcinnamaldehyde | increases expression | ISO | RGD:737343 | 6480464 | hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | amiodarone | increases expression | ISO | RGD:737343 | 6480464 | Amiodarone results in increased expression of MGST1 mRNA | CTD | PMID:19774075 | ammonium chloride | affects expression | ISO | RGD:70927 | 6480464 | Ammonium Chloride affects the expression of MGST1 mRNA | CTD | PMID:16483693 | arsenic atom | increases expression | ISO | RGD:737343 | 6480464 | Arsenic results in increased expression of MGST1 mRNA | CTD | PMID:19945496 | Bandrowski's base | increases expression | ISO | RGD:737343 | 6480464 | Bandrowski's base results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | benzo[a]pyrene | increases expression | ISO | RGD:737343 | 6480464 | Benzo(a)pyrene results in increased expression of MGST1 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of MGST1 mRNA | CTD | PMID:15034205 PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:737343 | 6480464 | Benzo(a)pyrene results in increased expression of MGST1 mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of MGST1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:737343 | 6480464 | Benzo(a)pyrene results in increased expression of MGST1 mRNA | CTD | PMID:20106945 PMID:22316170 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of MGST1 mRNA | CTD | PMID:18955075 PMID:15674843 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of MGST1 mRNA | CTD | PMID:15674843 PMID:18955075 | bisphenol A | decreases expression | ISO | RGD:70927 | 6480464 | bisphenol A results in decreased expression of MGST1 mRNA | CTD | PMID:12075121 | bisphenol A | increases methylation | ISO | RGD:737343 | 6480464 | bisphenol A results in increased methylation of MGST1 gene | CTD | PMID:22576693 | bisphenol A | decreases expression | ISO | RGD:737343 | 6480464 | bisphenol A results in decreased expression of MGST1 mRNA | CTD | PMID:22576693 | caffeine | decreases expression | ISO | RGD:737343 | 6480464 | Caffeine results in decreased expression of MGST1 mRNA | CTD | PMID:11793227 | cinnamyl alcohol | increases expression | ISO | RGD:737343 | 6480464 | cinnamyl alcohol results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | ciprofibrate | increases expression | EXP | | 6480464 | ciprofibrate results in increased expression of MGST1 mRNA | CTD | PMID:18723825 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of MGST1 mRNA | CTD | PMID:21151649 | cisplatin | decreases response to substance | ISO | RGD:737343 | 6480464 | MGST1 protein results in decreased susceptibility to Cisplatin | CTD | PMID:20727966 | clofibrate | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of MGST1 mRNA; more ... | CTD | PMID:17585979 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of MGST1 mRNA | CTD | PMID:18723825 | cobalt dichloride | increases expression | ISO | RGD:737343 | 6480464 | cobaltous chloride results in increased expression of MGST1 mRNA | CTD | PMID:17553155 | curcumin | increases expression | ISO | RGD:70927 | 6480464 | Curcumin results in increased expression of MGST1 mRNA | CTD | PMID:18299980 | cyclophosphamide | decreases expression | ISO | RGD:70927 | 6480464 | Cyclophosphamide results in decreased expression of MGST1 mRNA | CTD | PMID:11906922 | cyclosporin A | multiple interactions | ISO | RGD:70927 | 6480464 | Cyclosporine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] | CTD | PMID:19111564 | dexamethasone | multiple interactions | EXP | | 6480464 | EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]; more ... | CTD | PMID:16054899 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of MGST1 mRNA | CTD | PMID:18723825 | diazinon | increases expression | ISO | RGD:70927 | 6480464 | Diazinon results in increased expression of MGST1 mRNA | CTD | PMID:19440498 | diazoxide | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of MGST1 mRNA | CTD | PMID:20003209 | diazoxide | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of MGST1 mRNA | CTD | PMID:20003209 PMID:21335049 | dibutyl phthalate | decreases expression | ISO | RGD:70927 | 6480464 | Dibutyl Phthalate results in decreased expression of MGST1 mRNA | CTD | PMID:21266533 | dichlorine | decreases expression | ISO | RGD:70927 | 6480464 | Chlorine results in decreased expression of MGST1 mRNA | CTD | PMID:18636392 | dichlorine | multiple interactions | ISO | RGD:70927 | 6480464 | [Ozone co-treated with Chlorine] affects the expression of MGST1 mRNA | CTD | PMID:18636392 | dimethylarsinic acid | increases expression | ISO | RGD:70927 | 6480464 | Cacodylic Acid results in increased expression of MGST1 mRNA | CTD | PMID:16122865 | dioxygen | increases expression | EXP | | 6480464 | Oxygen results in increased expression of MGST1 mRNA; more ... | CTD | PMID:23337360 | dioxygen | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Oxygen results in increased expression of MGST1 protein] | CTD | PMID:23337360 | disodium selenite | increases expression | ISO | RGD:737343 | 6480464 | Sodium Selenite results in increased expression of MGST1 mRNA | CTD | PMID:18175754 | disodium selenite | decreases expression | ISO | RGD:737343 | 6480464 | Sodium Selenite results in decreased expression of MGST1 mRNA | CTD | PMID:16705456 | disulfiram | increases expression | ISO | RGD:737343 | 6480464 | Disulfiram results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | doxorubicin | increases expression | ISO | RGD:70927 | 6480464 | Doxorubicin results in increased expression of MGST1 mRNA | CTD | PMID:19915844 | eugenol | increases expression | ISO | RGD:737343 | 6480464 | Eugenol results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of MGST1 mRNA | CTD | PMID:11509743 | furan | increases methylation | ISO | RGD:70927 | 6480464 | furan results in increased methylation of MGST1 gene | CTD | PMID:22079235 | gallic acid | increases activity | ISO | RGD:70927 | 6480464 | Gallic Acid results in increased activity of MGST1 protein | CTD | PMID:19111564 | gallic acid | multiple interactions | ISO | RGD:70927 | 6480464 | Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; more ... | CTD | PMID:19111564 | genistein | decreases expression | ISO | RGD:70927 | 6480464 | Genistein results in decreased expression of MGST1 mRNA | CTD | PMID:12075121 | glutathione | multiple interactions | ISO | RGD:70927 | 6480464 | Glutathione binds to and results in increased activity of MGST1 protein; more ... | CTD | PMID:9890956 | glutathione | multiple interactions | ISO | RGD:70927 | 6480464 | MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; more ... | CTD | PMID:12470677 | hemin | multiple interactions | ISO | RGD:70927 | 6480464 | Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] | CTD | PMID:19111564 | hydrogen peroxide | decreases response to substance | ISO | RGD:70927 | 6480464 | MGST1 results in decreased susceptibility to Hydrogen Peroxide | CTD | PMID:17306223 | hydroquinone | increases expression | ISO | RGD:737343 | 6480464 | hydroquinone results in increased expression of MGST1 mRNA | CTD | PMID:15452088 | isoeugenol | increases expression | ISO | RGD:737343 | 6480464 | isoeugenol results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | isoprenaline | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of MGST1 mRNA | CTD | PMID:20003209 | isoprenaline | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of MGST1 mRNA | CTD | PMID:20003209 PMID:21335049 | kojic acid | multiple interactions | ISO | RGD:70927 | 6480464 | [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MGST1 mRNA; more ... | CTD | PMID:18544905 | L-ascorbic acid | increases expression | ISO | RGD:70927 | 6480464 | Ascorbic Acid results in increased expression of MGST1 mRNA | CTD | PMID:15372504 | lead diacetate | increases expression | ISO | RGD:70927 | 6480464 | lead acetate results in increased expression of MGST1 mRNA | CTD | PMID:11578147 | lead diacetate | increases expression | ISO | RGD:70927 | 6480464 | lead acetate results in increased expression of MGST1 mRNA | CTD | PMID:11578147 PMID:22641619 | leukotriene B4 | decreases activity | ISO | RGD:70927 | 6480464 | Leukotriene B4 results in decreased activity of MGST1 protein | CTD | PMID:9890956 | leukotriene C4 | multiple interactions | ISO | RGD:70927 | 6480464 | Leukotriene C4 binds to and results in decreased activity of MGST1 protein; more ... | CTD | PMID:9890956 | leukotriene D4 | decreases activity | ISO | RGD:70927 | 6480464 | Leukotriene D4 results in decreased activity of MGST1 protein | CTD | PMID:9890956 | leukotriene E4 | decreases activity | ISO | RGD:70927 | 6480464 | Leukotriene E4 results in decreased activity of MGST1 protein | CTD | PMID:9890956 | methimazole | increases expression | ISO | RGD:737343 | 6480464 | Methimazole results in increased expression of MGST1 mRNA | CTD | PMID:20144635 | methoxychlor | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of MGST1 mRNA | CTD | PMID:11509743 | methoxychlor | increases expression | EXP | | 6480464 | Methoxychlor metabolite results in increased expression of MGST1 mRNA | CTD | PMID:11509743 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of MGST1 mRNA | CTD | PMID:20061341 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:70927 | 6480464 | [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MGST1 mRNA; more ... | CTD | PMID:18544905 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:70927 | 6480464 | [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MGST1 protein | CTD | PMID:20935162 | nickel sulfate | increases expression | ISO | RGD:737343 | 6480464 | nickel sulfate results in increased expression of MGST1 mRNA | CTD | PMID:20566472 | ochratoxin A | decreases expression | ISO | RGD:70927 | 6480464 | ochratoxin A results in decreased expression of MGST1 mRNA | CTD | PMID:22124623 | ochratoxin A | decreases expression | ISO | RGD:70927 | 6480464 | ochratoxin A results in decreased expression of MGST1 mRNA | CTD | PMID:17483316 more ... | ochratoxin A | decreases expression | ISO | RGD:70927 | 6480464 | ochratoxin A results in decreased expression of MGST1 mRNA | CTD | PMID:17483316 PMID:22124623 | ochratoxin A | decreases expression | ISO | RGD:70927 | 6480464 | ochratoxin A results in decreased expression of MGST1 mRNA | CTD | PMID:22124623 PMID:17483316 | ozone | multiple interactions | ISO | RGD:70927 | 6480464 | [Ozone co-treated with Chlorine] affects the expression of MGST1 mRNA | CTD | PMID:18636392 | paracetamol | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of MGST1 mRNA; more ... | CTD | PMID:17585979 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MGST1 protein | CTD | PMID:21329376 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of MGST1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:737343 | 6480464 | Acetaminophen results in decreased expression of MGST1 mRNA | CTD | PMID:11793227 | paraquat | increases expression | ISO | RGD:70927 | 6480464 | Paraquat results in increased expression of MGST1 mRNA | CTD | PMID:17935786 | parathion | multiple interactions | ISO | RGD:737343 | 6480464 | [Parathion co-treated with Estradiol] results in increased expression of MGST1 mRNA | CTD | PMID:17982697 | parathion | increases expression | ISO | RGD:737343 | 6480464 | Parathion results in increased expression of MGST1 mRNA | CTD | PMID:17982697 | phenobarbital | multiple interactions | ISO | RGD:70927 | 6480464 | [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MGST1 protein | CTD | PMID:20935162 | phlorizin | increases expression | EXP | | 6480464 | Phlorhizin results in increased expression of MGST1 mRNA | CTD | PMID:22538082 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of MGST1 mRNA | CTD | PMID:17426115 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of MGST1 mRNA | CTD | PMID:21278054 | pyrimidin-2-amine | affects binding | ISO | RGD:70927 | 6480464 | 2-aminopyrimidine analog binds to MGST1 protein | CTD | PMID:19317514 | quercetin | affects expression | ISO | RGD:70927 | 6480464 | Quercetin affects the expression of MGST1 mRNA | CTD | PMID:18178720 | rosiglitazone | multiple interactions | EXP | | 6480464 | EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]; more ... | CTD | PMID:16054899 | S-nitrosoglutathione | affects metabolic processing | ISO | RGD:70927 | 6480464 | S-Nitrosoglutathione affects the metabolism of MGST1 protein | CTD | PMID:16899233 | spironolactone | increases expression | EXP | | 6480464 | Spironolactone results in increased expression of MGST1 mRNA | CTD | PMID:18723825 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of MGST1 mRNA | CTD | PMID:17555576 | tetrachloromethane | affects expression | ISO | RGD:70927 | 6480464 | Carbon Tetrachloride affects the expression of MGST1 mRNA | CTD | PMID:12734012 PMID:17805973 | tetrachloromethane | affects expression | ISO | RGD:70927 | 6480464 | Carbon Tetrachloride affects the expression of MGST1 mRNA | CTD | PMID:17805973 PMID:12734012 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of MGST1 mRNA | CTD | PMID:15056808 | thioacetamide | decreases expression | ISO | RGD:737343 | 6480464 | Thioacetamide results in decreased expression of MGST1 mRNA | CTD | PMID:11793227 | trimellitic anhydride | decreases expression | EXP | | 6480464 | trimellitic anhydride results in decreased expression of MGST1 mRNA | CTD | PMID:19042947 | tunicamycin | decreases expression | EXP | | 6480464 | Tunicamycin results in decreased expression of MGST1 mRNA | CTD | PMID:17127020 | zinc atom | decreases expression | ISO | RGD:70927 | 6480464 | Zinc deficiency results in decreased expression of MGST1 mRNA | CTD | PMID:11717422 | zinc(0) | decreases expression | ISO | RGD:70927 | 6480464 | Zinc deficiency results in decreased expression of MGST1 mRNA | CTD | PMID:11717422 | |
Gene Ontology AnnotationsBiological Process








