Gene: Ctsl (cathepsin L)  Mus musculus Symbol: Ctsl Name: cathepsin L Description: ENCODES a protein that exhibits aminopeptidase activity (ortholog); cysteine-type endopeptidase activity (ortholog); kininogen binding (ortholog); INVOLVED IN proteolysis; cell communication (ortholog); PARTICIPATES IN antigen processing and presentation pathway; rheumatoid arthritis pathway; ASSOCIATED WITH abnormal cartilage morphology; abnormal coat appearance; abnormal coat/ hair morphology; ASSOCIATED WITH Atherosclerosis; Colitis; Diabetes Mellitus, Type 1; FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol Type: protein-coding RefSeq Status: PROVISIONAL Also known as: 1190035F06Rik; Cat L; cathepsin L1; Ctsl1; fs; furless; major excreted protein; MEP; nackt; nkt; p39 cysteine proteinase Orthologs: Homo sapiens : CTSL2 (cathepsin L2)  HGNC Rattus norvegicus : Ctsl1 (cathepsin L1) Related Pseudogenes: Gm17885   Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,363,214 - 64,370,306 - NCBI Mouse cM Map 13 33.26   NCBI Mouse Celera Assembly 13 66,025,830 - 66,032,878 - NCBI Mouse Genome Assembly Build 37 13 64,464,522 - 64,471,614 - NCBI Mouse Genome Assembly Build 36.1 13 64,464,522 - 64,471,614 - NCBI Mouse Cytogenetic Map 13 B3   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Albuminuria   ISS RGD:2448 2315726 associated with Hypertension RGD   Atherosclerosis   IGI RGD:733604 5687152   RGD   Brain Ischemia   ISS RGD:2448 2315571 protein:increased activity:cerebrum (rat) RGD   Carcinoma, Hepatocellular   ISS RGD:2448 2315605   RGD   Cardiomyopathy, Hypertrophic   ISS RGD:736036 2315555   RGD   Colitis   IEP   5686873 protein:increased activity:cecum, colon, spinal cord RGD   Diabetes Mellitus, Experimental   ISS RGD:2448 1641826 mRNA:increased expression:gastrocnemius muscle (rat) RGD   Diabetes Mellitus, Type 1 Susceptibility IPM   2315524   RGD   Diabetes Mellitus, Type 2 Susceptibility IEP   2315625 mRNA:increased expression:gastrocnemius muscle (mouse) RGD   Diabetes Mellitus, Type 2   ISS RGD:736036 2315622 protein:increased expression:right auricular appendage (human) RGD   Hyperthyroidism   ISS RGD:2448 2315547 mRNA:increased expression:extensor digitorum longus (rat) RGD   Intervertebral Disc Displacement   ISS RGD:2448 2315595 protein:increased expression:annulus fibrosus (rat) RGD   Multiple Sclerosis   IEP   5686392   RGD   Muscular Atrophy   ISS RGD:2448 2315576 mRNA:increased expression:soleus (rat) RGD   Myasthenia Gravis, Autoimmune, Experimental   ISS RGD:2448 2315588 mRNA:increased expression:quadriceps (rat) RGD   Nephrotic Syndrome   ISS RGD:2448 1304337 mRNA, protein:increased expression:glomerulus (rat) RGD   Otitis Media   ISS RGD:2448 1342442 mRNA:decreased expression:middle ear mucosa (rat) RGD   Pancreatitis   ISS RGD:2448 2315546 protein:altered processing:pancreas (rat) RGD   Reoviridae Infections   IPM   5686877   RGD   Sprains and Strains   ISS RGD:2448 2315597 mRNA:increased expression:ligament (rat) RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (S)-nicotine multiple interactions EXP   6480464 Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA]; more ... CTD PMID:20230807 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:736036 6480464 Dinitrochlorobenzene results in increased expression of CTSL mRNA CTD PMID:17374397 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression EXP   6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP   6480464 Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA]; more ... CTD PMID:20230807 1-naphthyl isothiocyanate increases expression ISO RGD:2448 6480464 1-Naphthylisothiocyanate results in increased expression of CTSL mRNA CTD PMID:17522070 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of CTSL mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:2448 6480464 Ethinyl Estradiol results in increased expression of CTSL mRNA CTD PMID:17557909 17alpha-ethynylestradiol multiple interactions EXP   6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTSL mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP   6480464 Ethinyl Estradiol affects the expression of CTSL mRNA CTD PMID:17555576 17beta-estradiol affects expression EXP   6480464 Estradiol affects the expression of CTSL mRNA CTD PMID:15598610 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSL mRNA CTD PMID:15289156 17beta-hydroxy-5alpha-androstan-3-one decreases expression EXP   6480464 Dihydrotestosterone results in decreased expression of CTSL mRNA CTD PMID:17023530 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSL protein] CTD PMID:18172886 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2448 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:16960034 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2448 6480464 Tetrachlorodibenzodioxin affects the expression of CTSL1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:16114106 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL protein CTD PMID:18172213 PMID:18172886 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:16960034 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2448 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:19692669 PMID:16960034 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2448 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:16960034 PMID:19692669 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:16960034 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of CTSL mRNA CTD PMID:18343893 PMID:16611356 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2448 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:16960034 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2448 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL1 mRNA CTD PMID:18465118 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL protein CTD PMID:18172886 PMID:18172213 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of CTSL mRNA CTD PMID:20159946 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CTSL mRNA CTD PMID:18172213 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CTSL mRNA] CTD PMID:15667827 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTSL mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of CTSL mRNA CTD PMID:16611356 PMID:18343893 2-methoxyethanol increases expression ISO RGD:2448 6480464 methyl cellosolve results in increased expression of CTSL1 mRNA CTD PMID:21061450 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases response to substance EXP   6480464 CTSL gene mutant form results in decreased susceptibility to Puromycin Aminonucleoside CTD PMID:15197181 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions ISO RGD:2448 6480464 Puromycin Aminonucleoside results in increased activity of and results in increased expression of CTSL protein CTD PMID:15197181 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases activity ISO RGD:2448 6480464 Puromycin Aminonucleoside results in decreased activity of CTSL protein CTD PMID:10394110 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression ISO RGD:2448 6480464 Puromycin Aminonucleoside affects the expression of CTSL mRNA; more ... CTD PMID:15197181 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:2448 6480464 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CTSL mRNA CTD PMID:19692669 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:2448 6480464 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CTSL mRNA CTD PMID:19692669 PMID:20959002 3H-1,2-dithiole-3-thione decreases expression ISO RGD:2448 6480464 1,2-dithiol-3-thione results in decreased expression of CTSL mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane affects expression EXP   6480464 4,4'-diaminodiphenylmethane affects the expression of CTSL mRNA CTD PMID:18648102 4-hydroxynon-2-enal decreases expression ISO RGD:736036 6480464 4-hydroxy-2-nonenal results in decreased expression of CTSL1 mRNA CTD PMID:12419474 5-aza-2'-deoxycytidine increases expression ISO RGD:736036 6480464 decitabine results in increased expression of CTSL mRNA CTD PMID:16367923 aflatoxin B1 decreases expression EXP   6480464 Aflatoxin B1 results in decreased expression of CTSL mRNA CTD PMID:19770486 albendazole multiple interactions ISO RGD:736036 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL1 mRNA CTD PMID:16861626 all-trans-retinoic acid decreases expression ISO RGD:736036 6480464 Tretinoin results in decreased expression of CTSL protein CTD PMID:15059897 ammonium chloride affects expression ISO RGD:2448 6480464 Ammonium Chloride affects the expression of CTSL1 mRNA CTD PMID:16483693 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of CTSL mRNA CTD PMID:22228805 beryllium sulfate increases expression ISO RGD:736036 6480464 beryllium sulfate results in increased expression of CTSL mRNA CTD PMID:16314022 bis(2-chloroethyl) sulfide affects expression ISO RGD:2448 6480464 Mustard Gas affects the expression of CTSL mRNA CTD PMID:15651846 bromobenzene increases expression ISO RGD:2448 6480464 bromobenzene results in increased expression of CTSL mRNA CTD PMID:12628495 cadmium dichloride decreases methylation ISO RGD:2448 6480464 Cadmium Chloride results in decreased methylation of CTSL1 promoter CTD PMID:22457795 cadmium dichloride multiple interactions EXP   6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CTSL mRNA CTD PMID:19840844 cadmium dichloride increases expression ISO RGD:2448 6480464 Cadmium Chloride results in increased expression of CTSL1 protein CTD PMID:15618353 cadmium dichloride affects expression ISO RGD:2448 6480464 Cadmium Chloride affects the expression of CTSL1 mRNA CTD PMID:22110744 caffeine multiple interactions EXP   6480464 Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA]; more ... CTD PMID:20230807 carmustine increases expression ISO RGD:2448 6480464 Carmustine results in increased expression of CTSL mRNA CTD PMID:16005536 CCCP increases expression EXP   6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CTSL mRNA CTD PMID:15978749 chloroform increases expression ISO RGD:2448 6480464 Chloroform results in increased expression of CTSL mRNA CTD PMID:17522070 chloroquine increases expression ISO RGD:2448 6480464 Chloroquine results in increased expression of CTSL1 protein CTD PMID:2759144 choline affects expression ISO RGD:736036 6480464 Choline affects the expression of CTSL mRNA CTD PMID:17616785 cimetidine decreases activity ISO RGD:2448 6480464 Cimetidine results in decreased activity of CTSL1 protein CTD PMID:12903910 ciprofibrate increases expression EXP   6480464 ciprofibrate results in increased expression of CTSL mRNA CTD PMID:12771043 clofibrate multiple interactions EXP   6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CTSL mRNA; more ... CTD PMID:17585979 clofibrate decreases expression EXP   6480464 Clofibrate results in decreased expression of CTSL mRNA CTD PMID:17585979 cobalt dichloride increases expression ISO RGD:736036 6480464 cobaltous chloride results in increased expression of CTSL mRNA CTD PMID:19320972 copper atom increases expression ISO RGD:2448 6480464 Copper results in increased expression of CTSL mRNA CTD PMID:22465980 copper atom multiple interactions EXP   6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CTSL mRNA CTD PMID:15467011 copper(0) increases expression ISO RGD:2448 6480464 Copper results in increased expression of CTSL mRNA CTD PMID:22465980 copper(0) multiple interactions EXP   6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CTSL mRNA CTD PMID:15467011 copper(2+) sulfate increases expression ISO RGD:736036 6480464 Copper Sulfate results in increased expression of CTSL1 mRNA CTD PMID:19549813 cyclophosphamide increases expression ISO RGD:736036 6480464 Cyclophosphamide results in increased expression of CTSL mRNA CTD PMID:17403535 cyclosporin A decreases activity ISO RGD:736036 6480464 Cyclosporine results in decreased activity of CTSL1 protein CTD PMID:10914799 cyclosporin A increases expression ISO RGD:736036 6480464 Cyclosporine results in increased expression of CTSL1 mRNA CTD PMID:10914799 PMID:20106945 cyclosporin A increases expression ISO RGD:2448 6480464 Cyclosporine results in increased expression of CTSL1 mRNA CTD PMID:21865292 cyclosporin A increases expression ISO RGD:736036 6480464 Cyclosporine results in increased expression of CTSL1 mRNA CTD PMID:20106945 PMID:10914799 cytarabine decreases expression ISO RGD:736036 6480464 Cytarabine results in decreased expression of CTSL1 mRNA CTD PMID:21198554 dexamethasone increases expression ISO RGD:2448 6480464 Dexamethasone results in increased expression of CTSL mRNA CTD PMID:17522070 dexamethasone increases expression ISO RGD:2448 6480464 Dexamethasone results in increased expression of CTSL1 mRNA CTD PMID:20032058 PMID:14618091 dexamethasone multiple interactions ISO RGD:2448 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of CTSL1 mRNA] CTD PMID:20032058 dexamethasone increases expression ISO RGD:2448 6480464 Dexamethasone results in increased expression of CTSL1 mRNA CTD PMID:14618091 PMID:20032058 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of CTSL mRNA CTD PMID:20003209 dibutyl phthalate increases expression ISO RGD:2448 6480464 Dibutyl Phthalate results in increased expression of CTSL1 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP   6480464 Dibutyl Phthalate results in decreased expression of CTSL mRNA CTD PMID:21266533 dichlorine increases expression ISO RGD:2448 6480464 Chlorine results in increased expression of CTSL mRNA CTD PMID:18636392 dichlorine multiple interactions ISO RGD:2448 6480464 [Ozone co-treated with Chlorine] results in decreased expression of CTSL mRNA CTD PMID:18636392 diethylstilbestrol increases expression EXP   6480464 Diethylstilbestrol results in increased expression of CTSL mRNA CTD PMID:15289156 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of CTSL mRNA CTD PMID:19001878 doxorubicin multiple interactions EXP   6480464 PARP1 protein promotes the reaction [Doxorubicin results in increased expression of CTSL mRNA] CTD PMID:19001878 erythromycin estolate increases expression ISO RGD:2448 6480464 Erythromycin Estolate results in increased expression of CTSL mRNA CTD PMID:17522070 eugenol increases expression ISO RGD:736036 6480464 Eugenol results in increased expression of CTSL mRNA CTD PMID:17374397 fumonisin B1 increases expression EXP   6480464 fumonisin B1 results in increased expression of CTSL mRNA CTD PMID:16221962 genistein increases expression EXP   6480464 Genistein results in increased expression of CTSL mRNA CTD PMID:15289156 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of CTSL mRNA CTD PMID:20003209 ivermectin multiple interactions ISO RGD:736036 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL1 mRNA CTD PMID:16861626 methotrexate increases expression ISO RGD:2448 6480464 Methotrexate results in increased expression of CTSL mRNA CTD PMID:16005536 microcystin-LR increases expression EXP   6480464 cyanoginosin LR results in increased expression of CTSL mRNA CTD PMID:17654400 mono(2-ethylhexyl) phthalate increases expression ISO RGD:2448 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of CTSL mRNA CTD PMID:16809437 N-methyl-4-phenylpyridinium increases expression ISO RGD:2448 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CTSL mRNA CTD PMID:16026605 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP   6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CTSL mRNA; more ... CTD PMID:19840844 N-nitrosodiethylamine increases expression EXP   6480464 Diethylnitrosamine results in increased expression of CTSL mRNA CTD PMID:12771043 N-nitrosodiethylamine increases expression ISO RGD:2448 6480464 Diethylnitrosamine results in increased expression of CTSL1 mRNA CTD PMID:20360939 naloxone increases expression ISO RGD:2448 6480464 Naloxone results in increased expression of CTSL mRNA CTD PMID:17522070 nickel sulfate decreases expression ISO RGD:736036 6480464 nickel sulfate results in decreased expression of CTSL1 mRNA CTD PMID:16780908 nickel sulfate increases expression ISO RGD:736036 6480464 nickel sulfate results in increased expression of CTSL mRNA CTD PMID:17374397 nickel sulfate increases expression ISO RGD:736036 6480464 nickel sulfate results in increased expression of CTSL1 mRNA CTD PMID:16780908 okadaic acid multiple interactions EXP   6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CTSL mRNA CTD PMID:19840844 ozone multiple interactions ISO RGD:2448 6480464 [Ozone co-treated with Chlorine] results in decreased expression of CTSL mRNA CTD PMID:18636392 paclitaxel increases response to substance ISO RGD:736036 6480464 CTSL1 mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 paracetamol multiple interactions EXP   6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CTSL mRNA; more ... CTD PMID:17585979 paracetamol affects expression EXP   6480464 Acetaminophen affects the expression of CTSL mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:2448 6480464 Acetaminophen results in increased expression of CTSL mRNA CTD PMID:17522070 phenobarbital increases expression ISO RGD:2448 6480464 Phenobarbital results in increased expression of CTSL mRNA CTD PMID:19162173 phenytoin decreases activity ISO RGD:736036 6480464 Phenytoin results in decreased activity of CTSL1 protein CTD PMID:10914799 phenytoin increases expression ISO RGD:736036 6480464 Phenytoin results in increased expression of CTSL1 mRNA CTD PMID:10914799 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CTSL mRNA CTD PMID:19840844 pirimiphos-methyl increases activity ISO RGD:2448 6480464 pirimiphos methyl results in increased activity of CTSL protein CTD PMID:9204212 pirinixic acid decreases expression EXP   6480464 pirinixic acid results in decreased expression of CTSL mRNA CTD PMID:16221962 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of CTSL mRNA CTD PMID:18445702 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:2448 6480464 Pregnenolone Carbonitrile results in decreased expression of CTSL mRNA CTD PMID:19162173 propiconazole increases expression EXP   6480464 propiconazole results in increased expression of CTSL mRNA CTD PMID:22334560 ranitidine multiple interactions ISO RGD:2448 6480464 [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CTSL mRNA CTD PMID:16415329 sevoflurane affects expression ISO RGD:2448 6480464 sevoflurane affects the expression of CTSL1 mRNA CTD PMID:15967596 simvastatin increases expression ISO RGD:2448 6480464 Simvastatin results in increased expression of CTSL mRNA CTD PMID:19001041 tacrolimus hydrate multiple interactions EXP   6480464 Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSL protein] CTD PMID:18172886 tacrolimus hydrate increases expression ISO RGD:2448 6480464 Tacrolimus results in increased expression of CTSL1 mRNA CTD PMID:21865292 tamoxifen affects expression EXP   6480464 Tamoxifen affects the expression of CTSL mRNA CTD PMID:17555576 tert-butyl hydroperoxide decreases expression ISO RGD:736036 6480464 tert-Butylhydroperoxide results in decreased expression of CTSL1 mRNA CTD PMID:12419474 tert-butyl hydroperoxide increases expression ISO RGD:736036 6480464 tert-Butylhydroperoxide results in increased expression of CTSL1 mRNA CTD PMID:15336504 testosterone decreases expression EXP   6480464 Testosterone results in decreased expression of CTSL mRNA CTD PMID:20403060 testosterone multiple interactions ISO RGD:2448 6480464 Testosterone inhibits the reaction [Dexamethasone results in increased expression of CTSL1 mRNA] CTD PMID:20032058 tetrachloromethane increases expression ISO RGD:2448 6480464 Carbon Tetrachloride results in increased expression of CTSL mRNA CTD PMID:17522070 tetracycline increases expression ISO RGD:2448 6480464 Tetracycline results in increased expression of CTSL mRNA CTD PMID:17522070 theophylline decreases expression ISO RGD:2448 6480464 Theophylline results in decreased expression of CTSL mRNA CTD PMID:17522070 tioguanine increases expression ISO RGD:2448 6480464 Thioguanine results in increased expression of CTSL mRNA CTD PMID:16005536 topotecan affects response to substance ISO RGD:736036 6480464 CTSL1 protein affects the susceptibility to Topotecan CTD PMID:16217747 trichloroethene increases expression EXP   6480464 Trichloroethylene results in increased expression of CTSL mRNA CTD PMID:19254012 valproic acid affects expression EXP   6480464 Valproic Acid affects the expression of CTSL mRNA CTD PMID:17963808 vancomycin decreases expression EXP   6480464 Vancomycin results in decreased expression of CTSL mRNA CTD PMID:18930951 zinc atom increases expression ISO RGD:2448 6480464 Zinc results in increased expression of CTSL mRNA CTD PMID:17074742 zinc atom decreases expression ISO RGD:736036 6480464 Zinc results in decreased expression of CTSL mRNA CTD PMID:18316168 zinc sulfate increases expression ISO RGD:2448 6480464 Zinc Sulfate results in increased expression of CTSL mRNA CTD PMID:17074742 zinc(0) increases expression ISO RGD:2448 6480464 Zinc results in increased expression of CTSL mRNA CTD PMID:17074742 zinc(0) decreases expression ISO RGD:736036 6480464 Zinc results in decreased expression of CTSL mRNA CTD PMID:18316168 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell communication   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 epithelial tube branching involved in lung morphogenesis NOT IMP   2290270 MGI:MGI:3722010|PMID:17500053 UniProtKB MGI:MGI:3722010 PMID:17500053 metabolic process   TAS   2290270 MGI:MGI:3037364|PMID:14681235 GOC MGI:MGI:3037364 PMID:14681235 proteolysis   IDA   2290270 MGI:MGI:5009377|PMID:18957203 BHF-UCL MGI:MGI:5009377 PMID:18957203 stem cell differentiation   NAS   2290270 MGI:MGI:5009377|PMID:18957203 BHF-UCL MGI:MGI:5009377 PMID:18957203 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) apical part of cell colocalizes_with ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytoplasm   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 external side of plasma membrane   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 lysosome   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 microvillus   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 neuron projection   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleolus   NAS   2290270 MGI:MGI:5009356|PMID:20338168 BHF-UCL MGI:MGI:5009356 PMID:20338168 perikaryon   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 secretory granule colocalizes_with ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 vacuole   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) aminopeptidase activity   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cysteine-type endopeptidase activity   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cysteine-type peptidase activity   TAS   2290270 MGI:MGI:3037364|PMID:14681235 MGI MGI:MGI:3037364 PMID:14681235 histone binding   NAS   2290270 MGI:MGI:5009377|PMID:18957203 BHF-UCL MGI:MGI:5009377 PMID:18957203 hydrolase activity   IEA UniProtKB-KW:KW-0378 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 kininogen binding   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 peptidase activity   IEA UniProtKB-KW:KW-0645 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 peptide binding   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein binding   IPI UniProtKB:P12400 2290270 MGI:MGI:3037364|PMID:14681235 MGI MGI:MGI:3037364 PMID:14681235 protein complex binding   ISO RGD:2448 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) antigen processing and presentation pathway   IEA RGD:10424 6907045   KEGG mmu:04612 rheumatoid arthritis pathway   IEA RGD:10424 6907045   KEGG mmu:05323 External Database Links KEGG Pathway Antigen processing and presentation Lysosome Phagosome Rheumatoid arthritis Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal cartilage morphology   IAGP   5509061   MGI PMID:15154914 abnormal coat appearance   IAGP   5509061   MGI PMID:15154914 abnormal coat/ hair morphology   IAGP   5509061   MGI PMID:10199917 abnormal coat/ hair morphology   IAGP   5509061   MGI PMID:12163394 abnormal coat/ hair morphology   IAGP   5509061   MGI PMID:15154914 abnormal epidermis stratum basale morphology   IAGP   5509061   MGI PMID:11023992 abnormal external auditory canal morphology   IAGP   5509061   MGI PMID:12163394 abnormal hair cycle   IAGP   5509061   MGI PMID:11023992 abnormal hair cycle   IAGP   5509061   MGI PMID:15154914 abnormal hair cycle catagen phase   IAGP   5509061   MGI PMID:12163394 abnormal hair follicle development   IAGP   5509061   MGI PMID:11023992 abnormal hair follicle development   IAGP   5509061   MGI PMID:12163394 abnormal hair follicle morphology   IAGP   5509061   MGI PMID:10199917 abnormal hair follicle morphology   IAGP   5509061   MGI PMID:15154914 abnormal hair follicle orientation   IAGP   5509061   MGI PMID:15154914 abnormal hair growth   IAGP   5509061   MGI PMID:10199917 abnormal hair growth   IAGP   5509061   MGI PMID:12163394 abnormal hair growth   IAGP   5509061   MGI PMID:15154914 abnormal hair shaft morphology   IAGP   5509061   MGI PMID:11023992 abnormal hair shaft morphology   IAGP   5509061   MGI PMID:12163394 abnormal hair shaft morphology   IAGP   5509061   MGI PMID:15154914 abnormal hippocampus pyramidal cell layer   IAGP   5509061   MGI PMID:12048238 abnormal immune system organ morphology   IAGP   5509061   MGI PMID:10199917 abnormal immune system organ morphology   IAGP   5509061   MGI PMID:12163394 abnormal keratinocyte physiology   IAGP   5509061   MGI PMID:15154914 abnormal leukocyte cell number   IAGP   5509061   MGI PMID:15905545 abnormal lymph node cortex morphology   IAGP   5509061   MGI PMID:15905545 abnormal lymph node morphology   IAGP   5509061   MGI PMID:15905545 abnormal motor coordination/ balance   IAGP   5509061   MGI PMID:12048238 abnormal neuron apoptosis   IAGP   5509061   MGI PMID:12048238 abnormal osteoclast physiology   IAGP   5509061   MGI PMID:15154914 abnormal periodontal ligament morphology   IAGP   5509061   MGI PMID:12163394 abnormal pulp cavity morphology   IAGP   5509061   MGI PMID:12163394 abnormal seminiferous tubule morphology   IAGP   5509061   MGI PMID:12533435 abnormal spermatogenesis   IAGP   5509061   MGI PMID:12533435 abnormal thymus cortex morphology   IAGP   5509061   MGI PMID:15905545 abnormal thymus corticomedullary boundary morphology   IAGP   5509061   MGI PMID:15905545 abnormal thymus lobule morphology   IAGP   5509061   MGI PMID:15905545 abnormal thymus morphology   IAGP   5509061   MGI PMID:15905545 abnormal thyroid follicle morphology   IAGP   5509061   MGI PMID:12782676 abnormal thyroid gland morphology   IAGP   5509061   MGI PMID:12782676 abnormal thyroid hormone level   IAGP   5509061   MGI PMID:12782676 abnormal trabecular bone morphology   IAGP   5509061   MGI PMID:15154914 absent vibrissae   IAGP   5509061   MGI PMID:11023992 acanthosis   IAGP   5509061   MGI PMID:10199917 acanthosis   IAGP   5509061   MGI PMID:12163394 acanthosis   IAGP   5509061   MGI PMID:11023992 alopecia   IAGP   5509061   MGI PMID:10199917 alopecia   IAGP   5509061   MGI PMID:12163394 alopecia   IAGP   5509061   MGI PMID:15154914 alopecia   IAGP   5509061   MGI PMID:11023992 amyloidosis   IAGP   5509061   MGI PMID:17068745 cachexia   IAGP   5509061   MGI PMID:10199917 corneal opacity   IAGP   5509061   MGI PMID:12163394 decreased body size   IAGP   5509061   MGI PMID:12163394 decreased CD4-positive T cell number   IAGP   5509061   MGI PMID:10199917 decreased CD4-positive T cell number   IAGP   5509061   MGI PMID:19664906 decreased CD4-positive T cell number   IAGP   5509061   MGI PMID:15905545 decreased circulating thyroxine level   IAGP   5509061   MGI PMID:12782676 decreased long bone epiphyseal plate size   IAGP   5509061   MGI PMID:15154914 decreased osteoclast cell number   IAGP   5509061   MGI PMID:15154914 decreased susceptibility to autoimmune diabetes   IAGP   5509061   MGI PMID:19664906 decreased testis weight   IAGP   5509061   MGI PMID:12533435 decreased thyroxine level   IAGP   5509061   MGI PMID:12782676 decreased vertical activity   IAGP   5509061   MGI PMID:12048238 delayed hair appearance   IAGP   5509061   MGI PMID:11023992 delayed hair appearance   IAGP   5509061   MGI PMID:12163394 delayed hair appearance   IAGP   5509061   MGI PMID:12048238 dermatitis   IAGP   5509061   MGI PMID:10199917 dermatitis   IAGP   5509061   MGI PMID:12163394 dermatitis   IAGP   5509061   MGI PMID:15154914 dilated lymph node medullary sinus   IAGP   5509061   MGI PMID:15905545 enlarged lymph nodes   IAGP   5509061   MGI PMID:12163394 enlarged lymph nodes   IAGP   5509061   MGI PMID:15905545 enlarged sebaceous gland   IAGP   5509061   MGI PMID:10199917 enlarged sebaceous gland   IAGP   5509061   MGI PMID:12163394 epidermal hyperplasia   IAGP   5509061   MGI PMID:10199917 epidermal hyperplasia   IAGP   5509061   MGI PMID:12163394 epidermal hyperplasia   IAGP   5509061   MGI PMID:15154914 epidermal hyperplasia   IAGP   5509061   MGI PMID:11023992 excessive scratching   IAGP   5509061   MGI PMID:10199917 excessive scratching   IAGP   5509061   MGI PMID:12163394 focal dorsal hair loss   IAGP   5509061   MGI PMID:15154914 folliculitis   IAGP   5509061   MGI PMID:15154914 gliosis   IAGP   5509061   MGI PMID:12048238 granulomatous inflammation   IAGP   5509061   MGI PMID:15154914 hair follicle degeneration   IAGP   5509061   MGI PMID:11023992 hair follicle outer rooth sheath hyperplasia   IAGP   5509061   MGI PMID:11023992 hyperglycemia   IAGP   5509061   MGI PMID:19664906 hypergranulosis   IAGP   5509061   MGI PMID:10199917 hyperkeratosis   IAGP   5509061   MGI PMID:11023992 increased CD8-positive T cell number   IAGP   5509061   MGI PMID:15905545 increased inflammatory response   IAGP   5509061   MGI PMID:10199917 increased keratinocyte proliferation   IAGP   5509061   MGI PMID:11023992 increased regulatory T cell number   IAGP   5509061   MGI PMID:19664906 insulitis   IAGP   5509061   MGI PMID:19664906 liver inflammation   IAGP   5509061   MGI PMID:10199917 lymph node hyperplasia   IAGP   5509061   MGI PMID:10199917 lymph node inflammation   IAGP   5509061   MGI PMID:10199917 neuron degeneration   IAGP   5509061   MGI PMID:12048238 orthokeratosis   IAGP   5509061   MGI PMID:10199917 orthokeratosis   IAGP   5509061   MGI PMID:12163394 partial postnatal lethality   IAGP   5509061   MGI PMID:5563943 partial postnatal lethality   IAGP   5509061   MGI PMID:12048238 partial postnatal lethality   IAGP   5509061   MGI PMID:10199917 partial postnatal lethality   IAGP   5509061   MGI PMID:11023992 postnatal growth retardation   IAGP   5509061   MGI PMID:10199917 postnatal growth retardation   IAGP   5509061   MGI PMID:12048238 Purkinje cell degeneration   IAGP   5509061   MGI PMID:12048238 rough coat   IAGP   5509061   MGI PMID:10199917 salivary gland inflammation   IAGP   5509061   MGI PMID:19664906 scaly skin   IAGP   5509061   MGI PMID:11023992 shiny skin   IAGP   5509061   MGI PMID:11023992 short hair   IAGP   5509061   MGI PMID:15154914 short vibrissae   IAGP   5509061   MGI PMID:15154914 skin lesions   IAGP   5509061   MGI PMID:10199917 skin lesions   IAGP   5509061   MGI PMID:12163394 sparse hair   IAGP   5509061   MGI PMID:10199917 sparse hair   IAGP   5509061   MGI PMID:12163394 sparse vibrissae   IAGP   5509061   MGI PMID:15154914 thick dermal layer   IAGP   5509061   MGI PMID:11023992 thick dermal layer   IAGP   5509061   MGI PMID:12163394 thick epidermis   IAGP   5509061   MGI PMID:11023992 thick epidermis   IAGP   5509061   MGI PMID:12163394 thick epidermis   IAGP   5509061   MGI PMID:15154914 thick epidermis   IAGP   5509061   MGI PMID:12048238 thick skin   IAGP   5509061   MGI PMID:11023992 thymus atrophy   IAGP   5509061   MGI PMID:10199917 tremors   IAGP   5509061   MGI PMID:12048238 underdeveloped hair follicles   IAGP   5509061   MGI PMID:11023992 Disease Annotations Albuminuria  (ISS) Atherosclerosis  (IGI) Brain Ischemia  (ISS) Carcinoma, Hepatocellular  (ISS) Cardiomyopathy, Hypertrophic  (ISS) Colitis  (IEP) Diabetes Mellitus, Experimental  (ISS) Diabetes Mellitus, Type 1  (IPM) Diabetes Mellitus, Type 2  (IEP,ISS) Hyperthyroidism  (ISS) Intervertebral Disc Displacement  (ISS) Multiple Sclerosis  (IEP) Muscular Atrophy  (ISS) Myasthenia Gravis, Autoimmune, Experimental  (ISS) Nephrotic Syndrome  (ISS) Otitis Media  (ISS) Pancreatitis  (ISS) Reoviridae Infections  (IPM) Sprains and Strains  (ISS) Gene-Chemical Interaction Annotations (S)-nicotine  (EXP) 1-chloro-2,4-dinitrobenzene  (ISO) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP) 1-naphthyl isothiocyanate  (ISO) 17alpha-ethynylestradiol  (EXP,ISO) 17beta-estradiol  (EXP) 17beta-hydroxy-5alpha-androstan-3-one  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2-methoxyethanol  (ISO) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO) 3,3',4,4',5-pentachlorobiphenyl  (ISO) 3H-1,2-dithiole-3-thione  (ISO) 4,4'-diaminodiphenylmethane  (EXP) 4-hydroxynon-2-enal  (ISO) 5-aza-2'-deoxycytidine  (ISO) aflatoxin B1  (EXP) albendazole  (ISO) all-trans-retinoic acid  (ISO) ammonium chloride  (ISO) benzo[a]pyrene  (EXP) beryllium sulfate  (ISO) bis(2-chloroethyl) sulfide  (ISO) bromobenzene  (ISO) cadmium dichloride  (EXP,ISO) caffeine  (EXP) carmustine  (ISO) CCCP  (EXP) chloroform  (ISO) chloroquine  (ISO) choline  (ISO) cimetidine  (ISO) ciprofibrate  (EXP) clofibrate  (EXP) cobalt dichloride  (ISO) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) copper(2+) sulfate  (ISO) cyclophosphamide  (ISO) cyclosporin A  (ISO) cytarabine  (ISO) dexamethasone  (ISO) diazoxide  (EXP) dibutyl phthalate  (EXP,ISO) dichlorine  (ISO) diethylstilbestrol  (EXP) doxorubicin  (EXP) erythromycin estolate  (ISO) eugenol  (ISO) fumonisin B1  (EXP) genistein  (EXP) isoprenaline  (EXP) ivermectin  (ISO) methotrexate  (ISO) microcystin-LR  (EXP) mono(2-ethylhexyl) phthalate  (ISO) N-methyl-4-phenylpyridinium  (ISO) N-methyl-N'-nitro-N-nitrosoguanidine  (EXP) N-nitrosodiethylamine  (EXP,ISO) naloxone  (ISO) nickel sulfate  (ISO) okadaic acid  (EXP) ozone  (ISO) paclitaxel  (ISO) paracetamol  (EXP,ISO) phenobarbital  (ISO) phenytoin  (ISO) phorbol 13-acetate 12-myristate  (EXP) pirimiphos-methyl  (ISO) pirinixic acid  (EXP) pregnenolone 16alpha-carbonitrile  (ISO) propiconazole  (EXP) ranitidine  (ISO) sevoflurane  (ISO) simvastatin  (ISO) tacrolimus hydrate  (EXP,ISO) tamoxifen  (EXP) tert-butyl hydroperoxide  (ISO) testosterone  (EXP,ISO) tetrachloromethane  (ISO) tetracycline  (ISO) theophylline  (ISO) tioguanine  (ISO) topotecan  (ISO) trichloroethene  (EXP) valproic acid  (EXP) vancomycin  (EXP) zinc atom  (ISO) zinc sulfate  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process cell communication  (ISO) epithelial tube branching involved in lung morphogenesis  (IMP) metabolic process  (TAS) proteolysis  (IDA) stem cell differentiation  (NAS) Cellular Component apical part of cell  (ISO) cytoplasm  (ISO) external side of plasma membrane  (ISO) lysosome  (ISO) microvillus  (ISO) neuron projection  (ISO) nucleolus  (NAS) perikaryon  (ISO) secretory granule  (ISO) vacuole  (ISO) Molecular Function aminopeptidase activity  (ISO) cysteine-type endopeptidase activity  (ISO) cysteine-type peptidase activity  (TAS) histone binding  (NAS) hydrolase activity  (IEA) kininogen binding  (ISO) peptidase activity  (IEA) peptide binding  (ISO) protein binding  (IPI) protein complex binding  (ISO) Molecular Pathway Annotations antigen processing and presentation pathway  (IEA) rheumatoid arthritis pathway  (IEA) External Database Links KEGG Pathway Antigen processing and presentation Lysosome Phagosome Rheumatoid arthritis Phenotype Annotations abnormal cartilage morphology  (IAGP) abnormal coat appearance  (IAGP) abnormal coat/ hair morphology  (IAGP) abnormal epidermis stratum basale morphology  (IAGP) abnormal external auditory canal morphology  (IAGP) abnormal hair cycle  (IAGP) abnormal hair cycle catagen phase  (IAGP) abnormal hair follicle development  (IAGP) abnormal hair follicle morphology  (IAGP) abnormal hair follicle orientation  (IAGP) abnormal hair growth  (IAGP) abnormal hair shaft morphology  (IAGP) abnormal hippocampus pyramidal cell layer  (IAGP) abnormal immune system organ morphology  (IAGP) abnormal keratinocyte physiology  (IAGP) abnormal leukocyte cell number  (IAGP) abnormal lymph node cortex morphology  (IAGP) abnormal lymph node morphology  (IAGP) abnormal motor coordination/ balance  (IAGP) abnormal neuron apoptosis  (IAGP) abnormal osteoclast physiology  (IAGP) abnormal periodontal ligament morphology  (IAGP) abnormal pulp cavity morphology  (IAGP) abnormal seminiferous tubule morphology  (IAGP) abnormal spermatogenesis  (IAGP) abnormal thymus cortex morphology  (IAGP) abnormal thymus corticomedullary boundary morphology  (IAGP) abnormal thymus lobule morphology  (IAGP) abnormal thymus morphology  (IAGP) abnormal thyroid follicle morphology  (IAGP) abnormal thyroid gland morphology  (IAGP) abnormal thyroid hormone level  (IAGP) abnormal trabecular bone morphology  (IAGP) absent vibrissae  (IAGP) acanthosis  (IAGP) alopecia  (IAGP) amyloidosis  (IAGP) cachexia  (IAGP) corneal opacity  (IAGP) decreased body size  (IAGP) decreased CD4-positive T cell number  (IAGP) decreased circulating thyroxine level  (IAGP) decreased long bone epiphyseal plate size  (IAGP) decreased osteoclast cell number  (IAGP) decreased susceptibility to autoimmune diabetes  (IAGP) decreased testis weight  (IAGP) decreased thyroxine level  (IAGP) decreased vertical activity  (IAGP) delayed hair appearance  (IAGP) dermatitis  (IAGP) dilated lymph node medullary sinus  (IAGP) enlarged lymph nodes  (IAGP) enlarged sebaceous gland  (IAGP) epidermal hyperplasia  (IAGP) excessive scratching  (IAGP) focal dorsal hair loss  (IAGP) folliculitis  (IAGP) gliosis  (IAGP) granulomatous inflammation  (IAGP) hair follicle degeneration  (IAGP) hair follicle outer rooth sheath hyperplasia  (IAGP) hyperglycemia  (IAGP) hypergranulosis  (IAGP) hyperkeratosis  (IAGP) increased CD8-positive T cell number  (IAGP) increased inflammatory response  (IAGP) increased keratinocyte proliferation  (IAGP) increased regulatory T cell number  (IAGP) insulitis  (IAGP) liver inflammation  (IAGP) lymph node hyperplasia  (IAGP) lymph node inflammation  (IAGP) neuron degeneration  (IAGP) orthokeratosis  (IAGP) partial postnatal lethality  (IAGP) postnatal growth retardation  (IAGP) Purkinje cell degeneration  (IAGP) rough coat  (IAGP) salivary gland inflammation  (IAGP) scaly skin  (IAGP) shiny skin  (IAGP) short hair  (IAGP) short vibrissae  (IAGP) skin lesions  (IAGP) sparse hair  (IAGP) sparse vibrissae  (IAGP) thick dermal layer  (IAGP) thick epidermis  (IAGP) thick skin  (IAGP) thymus atrophy  (IAGP) tremors  (IAGP) underdeveloped hair follicles  (IAGP) References - curated 1. Aricha R, etal., FASEB J. 2006 Feb;20(2):374-6. Epub 2005 Dec 19. 2. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28. 3. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351. 4. Durmaz R, etal., Neurochem Res. 2008 Sep;33(9):1683-91. Epub 2008 Apr 11. 5. Hilliard LM, etal., Am J Nephrol. 2009;29(5):454-64. Epub 2008 Nov 21. 6. Hsing LC, etal., J Autoimmun. 2009 Aug 5. 7. Huang X, etal., Diabetes. 2003 Sep;52(9):2411-8. 8. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29. 9. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45. 10. Judge AR, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C372-82. Epub 2006 Aug 23. 11. Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. 12. Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51. 13. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6. 14. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4. 15. Mareninova OA, etal., J Clin Invest. 2009 Nov;119(11):3340-55. doi: 10.1172/JCI38674. Epub 2009 Oct 1. 16. Meng W, etal., J Musculoskelet Neuronal Interact. 2001 Dec;2(2):171-6. 17. MGD and Homologene mouse data transfer 18. MGD data from the GO Consortium 19. MGD IEA 20. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94. 21. O'Neal P, etal., J Cell Biochem. 2009 Nov 1;108(4):963-73. 22. Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. 23. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 24. Provenzano PP, etal., Matrix Biol. 2005 Jan;23(8):543-55. Epub 2004 Dec 1. 25. Reiser J, etal., J Biol Chem 2004 Aug 13;279(33):34827-32. Epub 2004 Jun 14. 26. RGD automated import pipeline 27. RGD automated import pipeline for gene-chemical interactions 28. Sebzda T, etal., World J Gastroenterol. 2005 Jan 28;11(4):587-92. 29. Sodha NR, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H428-34. Epub 2008 Dec 12. 30. Sol-Church K, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):23-9. 31. Sol-Church K, etal., Biochim Biophys Acta 2000 Apr 25;1491(1-3):289-94. 32. Sriraman V and Richards JS, Endocrinology 2004 Feb;145(2):582-91. Epub 2003 Oct 16. 33. Stypmann J, etal., Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6234-9. Epub 2002 Apr 23. 34. Sukhova GK, etal., J Clin Invest. 1998 Aug 1;102(3):576-83. 35. Tang Q, etal., J Mol Med. 2009 Mar;87(3):249-60. Epub 2008 Dec 19. References - uncurated PubMed 10199917   10349636   10395917   10516062   10600178   10633857   10748235   10922068   11022031   11023992   11042159   11076861   11119260   11398968   11483509   11829493   11830565   11884425   11929604   11978977   11986312   12000732   12014504   12021314   12048238   12163394   12186844   12368909   12417635   12466121   12477932   12533435   12676526   12775715   12782676   12815617   12867662   12869695   12904583   14681235   14681479   15099520   15154914   15308097   15489334   15582152   15665831   15679121   15782199   15831716   15860733   15905545   15905550   16079282   16140986   16141072   16141073   16170054   16184198   16314482   16393949   16481467   16508006   16602821   16621972   16636100   16705169   16731916   16895486   16939398   17068745   17222401   17404153   17500053   1751032   17519890   17622569   17643114   17671649   17697143   17765022   17942402   18292516   18362148   18410501   18450756   18469859   18591414   18776147   18829740   18849346   18957203   19028686   19589362   19801522   19837164   19900452   20017393   20023699   20075068   20080943   20304958   20338168   2034277   20428172   20495178   20497254   20536383   20562862   20877570   21147810   21251246   21292981   21434350   21750527   21868704   21956111   21972973   22126332   22245096   22451661   22668694   2275556   23315080   2826441   2835398   3533924   3689328   3755373   5563943   7774911   8043949   8419312   8554545   9096102   9310336   9507200   9545226 RGD Disease Portals Ctsl has been annotated in the following RGD Disease Portals. Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Neurological Diseases Neurological Pathways Neurological Phenotypes Obesity Diseases Obesity Phenotypes Respiratory Pathways Genomics Comparative Map Data Ctsl   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,363,214 - 64,370,306 - NCBI Mouse cM Map 13 33.26   NCBI Mouse Celera Assembly 13 66,025,830 - 66,032,878 - NCBI Mouse Genome Assembly Build 37 13 64,464,522 - 64,471,614 - NCBI Mouse Genome Assembly Build 36.1 13 64,464,522 - 64,471,614 - NCBI Mouse Cytogenetic Map 13 B3   NCBI CTSL2   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 9 99,808,429 - 99,818,395 - NCBI Human Genome Assembly HuRef 9 69,392,607 - 69,402,573 - NCBI Human Genome Assembly GRCh37 9 99,791,959 - 99,801,925 - NCBI Human Genome Assembly Build 36 9 98,834,758 - 98,841,360 - NCBI Human Cytogenetic Map 9 q22.2   NCBI Human Genome Assembly 9 96,874,491 - 96,881,094   NCBI Ctsl1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 17 p14   NCBI RGSC Genome Assembly v5.0 17 1,861,403 - 1,867,564 - NCBI RGSC Genome Assembly v3.4 17 6,288,013 - 6,294,174 + NCBI Rat Celera Assembly 17 1,745,833 - 1,751,993 - NCBI Genome Assembly 3.1 17 6,288,015 - 6,294,173 + NCBI RH 3.4 17 16.0   RGD Position Markers Ctsl   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,364,077 - 64,365,302   UniSTS Mouse cM Map 13 30.0   UniSTS Mouse Celera Assembly 13 66,026,692 - 66,027,919   UniSTS Mouse Genome Assembly Build 37 13 64,465,385 - 64,466,610   UniSTS Mouse Cytogenetic Map 13 B3   UniSTS MGI:6430   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,369,188 - 64,370,170   UniSTS Mouse cM Map 13 30.0   UniSTS Mouse Celera Assembly 13 66,031,760 - 66,032,742   UniSTS Mouse Genome Assembly Build 37 13 64,470,496 - 64,471,478   UniSTS Mouse Cytogenetic Map 13 B3   UniSTS MGI:6402   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,363,870 - 64,363,972   UniSTS Mouse cM Map 13 30.0   UniSTS Mouse Celera Assembly 13 66,026,485 - 66,026,587   UniSTS Mouse Genome Assembly Build 37 13 64,465,178 - 64,465,280   UniSTS Mouse Cytogenetic Map 13 B3   UniSTS Ctsl   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,366,581 - 64,366,990   UniSTS Mouse Celera Assembly 13 66,029,178 - 66,029,587   UniSTS Mouse Genome Assembly Build 37 13 64,467,889 - 64,468,298   UniSTS Mouse Cytogenetic Map 13 B3   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 4142009 Pregq3_m pregnancy QTL 3 (mouse) Not determined 13 20523211 72374518 Mouse 1357719 Hipp3_m hippocampal weight 3 (mouse) Not determined 13 30811017 64811164 Mouse 1558954 Hypism_m hyperinsulinemia (mouse) Not determined 13 34863276 68863414 Mouse 1357795 Hdlcl2_m HDL cholesterol level 2 (mouse) Not determined 13 34863276 68863414 Mouse 1301299 Sluc23_m susceptibility to lung cancer 23 (mouse) Not determined 13 34863276 68863414 Mouse 1301734 Acsns2_m Angiostrongylus costaricensis nematode susceptibility 2 (mouse) Not determined 13 36042863 70042973 Mouse 1357587 Pfat3_m predicted fat percentage 3 (mouse) Not determined 13 36042863 70042973 Mouse 1300561 Heal7_m wound healing/regeneration 7 (mouse) Not determined 13 36086153 70086237 Mouse 1300972 Cocia11_m cocaine induced activation 11 (mouse) Not determined 13 37579545 71579665 Mouse 1300862 Cfbw5_m cystic fibrosis body weight 5 (mouse) Not determined 13 38673906 72674065 Mouse 4141331 Cplaq11_m circadian period of locomotor activity 11 (mouse) Not determined 13 38673906 72674065 Mouse 1302157 Bwem2_m body weight day 30 males 2 (mouse) Not determined 13 39582797 73582945 Mouse 1301801 Cpfd5_m cerebellum pattern fissures (mouse) Not determined 13 39582797 73582945 Mouse 1558810 Crhtaq3_m Crh transcript abundance QTL 3 (mouse) Not determined 13 39786703 73786834 Mouse 1300668 Pas10_m pulmonary adenoma susceptibility 10 (mouse) Not determined 13 41442589 75442705 Mouse 1300916 Mobe2_m modifier of obesity 2 (mouse) Not determined 13 50271283 84271431 Mouse 1301666 Eae13_m susceptibility to experimental allergic encephalomyelitis 13 (mouse) Not determined 13 50271283 84271431 Mouse 1302073 Pgct1_m primordial germ cell tumor locus 1 (mouse) Not determined 13 53811542 87811656 Mouse 1300686 C10bw4_m castaneus 10 week body weight 4 (mouse) Not determined 13 55374309 89374469 Mouse 1357563 Bmch6_m bone mechanical trait 6 (mouse) Not determined 13 55374309 89374469 Mouse 1300705 Lipq2_m lipoprotein QTL 2 (mouse) Not determined 13 56132906 90133052 Mouse 1301949 Skull20_m skull morphology 20 (mouse) Not determined 13 64241701 98241825 Mouse 1357654 Manln14_m mandible length 14 (mouse) Not determined 13 64241701 98241825 Mouse 1300941 Skl6_m skeletal size (tail length) 6 (mouse) Not determined 13 64241701 98241825 Mouse 1301665 Bglq10_m body growth late QTL 10 (mouse) Not determined 13 64241701 98241825 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_009984 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01107115 (Get FASTA) Search GEO for Microarray Profiles   AF121837 (Get FASTA) Search GEO for Microarray Profiles   AF121838 (Get FASTA) Search GEO for Microarray Profiles   AF121839 (Get FASTA) Search GEO for Microarray Profiles   AK002221 (Get FASTA) Search GEO for Microarray Profiles   AK011589 (Get FASTA) Search GEO for Microarray Profiles   AK028038 (Get FASTA) Search GEO for Microarray Profiles   AK040402 (Get FASTA) Search GEO for Microarray Profiles   AK049466 (Get FASTA) Search GEO for Microarray Profiles   AK136341 (Get FASTA) Search GEO for Microarray Profiles   AK145051 (Get FASTA) Search GEO for Microarray Profiles   AK147142 (Get FASTA) Search GEO for Microarray Profiles   AK150452 (Get FASTA) Search GEO for Microarray Profiles   AK151169 (Get FASTA) Search GEO for Microarray Profiles   AK153076 (Get FASTA) Search GEO for Microarray Profiles   AK153417 (Get FASTA) Search GEO for Microarray Profiles   AK159511 (Get FASTA) Search GEO for Microarray Profiles   AK160100 (Get FASTA) Search GEO for Microarray Profiles   AK161538 (Get FASTA) Search GEO for Microarray Profiles   AK165397 (Get FASTA) Search GEO for Microarray Profiles   AK169394 (Get FASTA) Search GEO for Microarray Profiles   AK169712 (Get FASTA) Search GEO for Microarray Profiles   AK190042 (Get FASTA) Search GEO for Microarray Profiles   AK190644 (Get FASTA) Search GEO for Microarray Profiles   BC068163 (Get FASTA) Search GEO for Microarray Profiles   CH466631 (Get FASTA) Search GEO for Microarray Profiles   CT030159 (Get FASTA) Search GEO for Microarray Profiles   J02583 (Get FASTA) Search GEO for Microarray Profiles   M20495 (Get FASTA) Search GEO for Microarray Profiles   X04392 (Get FASTA) Search GEO for Microarray Profiles   X06086 (Get FASTA) Search GEO for Microarray Profiles   Y18465 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_009984 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_034114 Peptide Label: preproprotein Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 64,363,214 - 64,370,306 - ENTREZGENE Mouse cM Map 13   - ENTREZGENE Mouse Celera Assembly 13 66,025,830 - 66,032,878 - RGD Mouse Genome Assembly Build 37 13 64,464,522 - 64,471,614 - RGD Protein Sequences Protein RefSeqs NP_034114 (Get FASTA) GenBank Protein AAA37445 (Get FASTA)   AAA39984 (Get FASTA)   AAD32136 (Get FASTA)   AAD32137 (Get FASTA)   AAD32138 (Get FASTA)   AAH68163 (Get FASTA)   BAB21945 (Get FASTA)   BAB27719 (Get FASTA)   BAC33761 (Get FASTA)   BAE22939 (Get FASTA)   BAE26206 (Get FASTA)   BAE27712 (Get FASTA)   BAE29572 (Get FASTA)   BAE30172 (Get FASTA)   BAE31701 (Get FASTA)   BAE31977 (Get FASTA)   BAE35143 (Get FASTA)   BAE35627 (Get FASTA)   BAE36450 (Get FASTA)   BAE38161 (Get FASTA)   BAE41141 (Get FASTA)   BAE41323 (Get FASTA)   CAA27980 (Get FASTA)   CAA29470 (Get FASTA)   CAA77183 (Get FASTA)   EDL16242 (Get FASTA)   P06797 (Get FASTA) Promoters RGD ID: 6847029 Promoter ID: MM_ACW:13632 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: BoneMarrow_0Hour,   BoneMarrow_4Hour,   MEF_B6 Transcripts: CTSL.ESEP07-UNSPLICED Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 13 64,465,131 - 64,465,631 - MPROMDB RGD ID: 6823791 Promoter ID: MM_KWN:14476 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: 3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen Transcripts: NM_009984 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 13 64,471,466 - 64,471,966 - MPROMDB RGD ID: 6887514 Promoter ID: EPDNEW_M7207 Type: preliminary Name: Ctsl_1 Description: cathepsin L SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 13 64,471,614 - 64,471,674   EPDNEW Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000021477 ENTREZGENE Ensembl Protein ENSMUSP00000021933 ENTREZGENE Ensembl Transcript ENSMUST00000021933 ENTREZGENE Entrez Gene 13039 ENTREZGENE Germonline ENSMUSG00000021477 HomoloGene Group ID 76699 ENTREZGENE InterPro Pept_asp_AS UniProtKB/Swiss-Prot   Pept_cys_AS UniProtKB/Swiss-Prot   Pept_his_AS UniProtKB/Swiss-Prot   Peptidase_C1A UniProtKB/Swiss-Prot   Peptidase_C1A_C UniProtKB/Swiss-Prot   Prot_inhib_I29 UniProtKB/Swiss-Prot KEGG Report mmu:13039 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:88564 ENTREZGENE PANTHER Peptidase_C1A UniProtKB/Swiss-Prot Pfam Inhibitor_I29 UniProtKB/Swiss-Prot   Peptidase_C1 UniProtKB/Swiss-Prot PharmGKB CTSL1 RGD PRINTS PAPAIN UniProtKB/Swiss-Prot PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot   THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot   THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot SMART Inhibitor_I29 UniProtKB/Swiss-Prot   Pept_C1 UniProtKB/Swiss-Prot UniGene Mm.930 ENTREZGENE UniProt CATL1_MOUSE UniProtKB/Swiss-Prot   Q3TNC8_MOUSE UniProtKB/TrEMBL   Q3TT75_MOUSE UniProtKB/TrEMBL   Q3TVJ1_MOUSE UniProtKB/TrEMBL   Q3U5U9_MOUSE UniProtKB/TrEMBL   Q3UHZ4_MOUSE UniProtKB/TrEMBL   Q3UWH6_MOUSE UniProtKB/TrEMBL   Q543M3_MOUSE UniProtKB/TrEMBL   Q6LAF5_MOUSE UniProtKB/TrEMBL   Q9D0C0_MOUSE UniProtKB/TrEMBL

More on Ctsl Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 10424 Created: 2000-05-25 Species: Mus musculus Last Modified: 2013-04-02 Status: ACTIVE