Gene: Il1a (interleukin 1 alpha)  Mus musculus Symbol: Il1a Name: interleukin 1 alpha Description: ENCODES a protein that exhibits copper ion binding (ortholog); cytokine activity (ortholog); INVOLVED IN positive regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation vascular endothelial growth factor production; PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; graft-versus-host disease pathway; ASSOCIATED WITH abnormal inflammatory response; abnormal tumor vascularization; decreased circulating corticosterone level; ASSOCIATED WITH Acute Kidney Injury; Alveolitis, Extrinsic Allergic; Diabetes Mellitus, Type 1; FOUND IN cell surface (ortholog); cytosol (ortholog); extracellular space (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-chloro-2,4-dinitrobenzene; 17beta-estradiol Type: protein-coding RefSeq Status: PROVISIONAL Also known as: IL-1 alpha; Il-1a; interleukin-1 alpha; OTTMUSP00000016430 Orthologs: Homo sapiens : IL1A (interleukin 1, alpha)  HGNC Rattus norvegicus : Il1a (interleukin 1 alpha) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 129,299,610 - 129,309,972 - NCBI Mouse cM Map 2 62.9   NCBI Mouse Celera Assembly 2 130,527,298 - 130,537,642 - NCBI Mouse Genome Assembly Build 37 2 129,125,346 - 129,135,708 - NCBI Mouse Genome Assembly Build 36.1 2 129,125,346 - 129,135,708 - NCBI Mouse Cytogenetic Map 2 F   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   IPM   6907069   RGD   Alveolitis, Extrinsic Allergic   IEP   4142832 protein:increased expression:Bronchoalveolar Lavage Fluid RGD   Alzheimer Disease   ISS   1358667   RGD   Arthritis, Experimental   ISS RGD:2890 6907373   RGD   Arthritis, Rheumatoid   ISS RGD:735707 4142818 associated with lung disease, interstitial RGD   Asthma   ISS RGD:735707 4142802 DNA:polymorphisms: : RGD   Brain Injuries   ISS RGD:2890 2311098 mRNA, protein:increased expression:cerebral cortex RGD   Carcinoma, Non-Small-Cell Lung   ISS RGD:735707 4142793 DNA:SNPs: : RGD   Cholestasis   ISS RGD:2890 2311076 protein:increased expression:liver RGD   Common Cold   ISS RGD:735707 4143183 protein:increased expression:nasal mucus RGD   Cystic Fibrosis Severity ISS RGD:735707 4142849 protein:increased expression:serum RGD   Diabetes Mellitus, Experimental   ISS RGD:2890 4142788 protein:increased expression:heart RGD   Diabetes Mellitus, Type 1   ISS RGD:735707 2311075   RGD   Diabetes Mellitus, Type 1   IEP   2311067 mRNA:increased expression:pancreatic islet, leukocyte RGD   Diabetes Mellitus, Type 1   ISS RGD:735707 2311064   RGD   Diabetes Mellitus, Type 1   ISS RGD:735707 2311065 protein:increased expression:small intestine mucosa RGD   Diabetic Retinopathy   ISS RGD:735707 2307061 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor RGD   Endotoxemia   IEP   6907109   RGD   Fabry Disease   ISS RGD:735707 6907117 DNA:SNP:promoter:-889C>T (human) RGD   Femoral Fractures   ISS RGD:2890 5131471 protein:increased expression:lung, serum RGD   Fetal Growth Retardation   ISS RGD:735707 2311066 mRNA:increased expression:placenta RGD   Glomerulonephritis   IEP   6907108 associated with Malaria RGD   Glomerulonephritis, IGA No_Association ISS RGD:735707 6907116 DNA:SNP:promoter:-889C>T (human) RGD   Heat Stroke   ISS RGD:2890 6907071 protein:increased expression:plasma RGD   Hyperglycemia   ISS RGD:735707 2311062 associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:plasma RGD   Influenza, Human   IEP   4142860 protein:increased expression:lung RGD   Kidney Failure, Chronic   ISS RGD:735707 6907105 DNA:SNP, insertion/deletion:intron, 3' utr:rs1516792-3, rs16347-2 (human) RGD   Kidney Failure, Chronic No_Association ISS RGD:735707 6907070 DNA:SNP RGD   Kidney Failure, Chronic   ISS RGD:735707 6907106 DNA:SNPs, deletion, haplotypes:3' utr:multiple (human) RGD   Lung Diseases   IEP   4142805 lung injury; more ... RGD   Lung Diseases   ISS RGD:735707 4142811 radiation pneumonitis; more ... RGD   Lung Diseases   IEP   4142809 lung injury; more ... RGD   Lung Diseases, Interstitial Susceptibility ISS RGD:735707 4142806 associated with sclerosis: DNA:SNPs:5' UTR, exon, intron: RGD   Nasal Polyps   ISS RGD:735707 4142855 DNA:SNPs:exon: RGD   Nasal Polyps Susceptibility ISS RGD:735707 4142804 associated with asthma; more ... RGD   Osteoporosis   ISS RGD:735707 6907107 associated with Arthritis, Rheumatoid RGD   Otitis Media   ISS RGD:2890 4891398 associated with Haemophilus Infections; more ... RGD   Pancreatic Neoplasms   ISS RGD:735707 2311069   RGD   Pancreatic Neoplasms   ISS RGD:735707 2317657   RGD   Periodontitis   ISS RGD:735707 6906881 mRNA:increased expression:gingiva RGD   Pneumonia, Aspiration   ISS RGD:2890 4142854 protein:increased expression:Bronchoalveolar Lavage Fluid RGD   Pulmonary Fibrosis   ISS RGD:2890 4142838 mRNA, protein:increased expression:alveolar macrophage: RGD   Pulmonary Fibrosis   ISS RGD:735707 4142803 idiopathic pulmonary fibrosis; more ... RGD   Radiation Pneumonitis Susceptibility ISS RGD:735707 5131286 associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1800587,rs17561(human) RGD   Reperfusion Injury   ISS RGD:2890 2314952 mRNA:increased expression:lung RGD   Reperfusion Injury   ISS RGD:2890 6907377 protein:increased expression:serum RGD   Respiratory Hypersensitivity   IPM   4143222   RGD   Rhinitis, Allergic, Perennial   ISS RGD:735707 4142859 DNA:polymorphism:exon:c.4845G>T (human) RGD   Sclerosis Susceptibility ISS RGD:735707 4142806 DNA:SNPs:5' UTR, exon, intron: RGD   Shock, Hemorrhagic   ISS RGD:2890 2311100 mRNA:increased expression:lung RGD   Tuberculosis, Pulmonary   IEP   4142835   RGD   Urinary Tract Infections   IEP   6907113   RGD   Urinary Tract Infections   ISS RGD:2890 2311084 protein:increased expression:urine RGD   Varicocele   ISS RGD:2890 2311094 protein:increased expression:testis RGD   Venous Thrombosis   ISS RGD:2890 2311092   RGD   Wounds and Injuries   ISS RGD:2890 2311088   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-alpha-tocopherol multiple interactions ISO RGD:2890 6480464 alpha-Tocopherol inhibits the reaction [Lindane results in increased expression of IL1A mRNA]; more ... CTD PMID:15025948 (-)-epigallocatechin 3-gallate multiple interactions EXP   6480464 epigallocatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:7665919 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:735707 6480464 epigallocatechin gallate results in decreased expression of IL1A mRNA CTD PMID:20706672 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735707 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL1A mRNA CTD PMID:22079256 (R)-mevalonic acid multiple interactions ISO RGD:735707 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] CTD PMID:15728660 (R)-mevalonic acid multiple interactions ISO RGD:2890 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; more ... CTD PMID:15705589 (S)-nicotine multiple interactions ISO RGD:735707 6480464 Nicotine results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 1,3-dinitrobenzene increases expression ISO RGD:2890 6480464 3-dinitrobenzene results in increased expression of IL1A mRNA CTD PMID:22841810 1-chloro-2,4-dinitrobenzene increases expression EXP   6480464 Dinitrochlorobenzene results in increased expression of IL1A mRNA; more ... CTD PMID:18652873 1-chloro-2,4-dinitrobenzene increases activity EXP   6480464 Dinitrochlorobenzene results in increased activity of IL1A protein CTD PMID:15840424 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:2890 6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IL1A mRNA CTD PMID:22940226 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:2890 6480464 guggulu extract inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IL1A mRNA] CTD PMID:22940226 17beta-estradiol multiple interactions ISO RGD:2890 6480464 Estradiol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1A protein] CTD PMID:21127968 17beta-estradiol multiple interactions ISO RGD:735707 6480464 Estradiol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to CCL2 promoter]]; more ... CTD PMID:10614622 17beta-estradiol decreases expression ISO RGD:735707 6480464 Estradiol results in decreased expression of IL1A mRNA CTD PMID:10731640 17beta-estradiol multiple interactions EXP   6480464 Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; more ... CTD PMID:12079510 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of IL1A mRNA CTD PMID:11473722 17beta-estradiol multiple interactions EXP   6480464 daidzein inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; more ... CTD PMID:11473722 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] decreases expression ISO RGD:735707 6480464 nebivolol results in decreased expression of IL1A mRNA CTD PMID:17467819 2,2,2-trichloroethanol increases expression ISO RGD:735707 6480464 2,2,2-trichloroethanol results in increased expression of IL1A protein CTD PMID:23041168 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735707 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of IL1A mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735707 6480464 Tetrachlorodibenzodioxin results in increased expression of IL1A mRNA CTD PMID:19684285 PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735707 6480464 Tetrachlorodibenzodioxin results in increased expression of IL1A mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735707 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL1A mRNA CTD PMID:16039398 2,4-dinitrotoluene affects expression ISO RGD:2890 6480464 2,4-dinitrotoluene affects the expression of IL1A mRNA CTD PMID:21346803 2,6-di-tert-butyl-4-methylphenol multiple interactions EXP   6480464 Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:2890 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of IL1A mRNA]; more ... CTD PMID:17109745 2-amino-2-deoxy-D-glucopyranose increases expression ISO RGD:2890 6480464 Glucosamine results in increased expression of IL1A mRNA CTD PMID:17109745 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:735707 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; more ... CTD PMID:15728660 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:2890 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; more ... CTD PMID:15705589 3-methylcholanthrene increases expression ISO RGD:735707 6480464 Methylcholanthrene results in increased expression of IL1A mRNA CTD PMID:14993811 3H-1,2-dithiole-3-thione decreases expression ISO RGD:2890 6480464 1,2-dithiol-3-thione results in decreased expression of IL1A mRNA CTD PMID:19162173 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP   6480464 Oxazolone results in increased expression of IL1A protein CTD PMID:18652873 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP   6480464 Oxazolone results in increased expression of IL1A protein CTD PMID:18652873 PMID:11851881 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP   6480464 Oxazolone results in increased expression of IL1A protein CTD PMID:11851881 PMID:18652873 4-(ethoxymethylene)-2-phenyloxazol-5-one multiple interactions EXP   6480464 Clofibrate inhibits the reaction [Oxazolone results in increased expression of IL1A protein] CTD PMID:11851881 4-hydroxynon-2-enal decreases expression EXP   6480464 4-hydroxy-2-nonenal results in decreased expression of IL1A mRNA CTD PMID:19191707 4-hydroxyphenyl retinamide decreases expression EXP   6480464 Fenretinide results in decreased expression of IL1A mRNA CTD PMID:16467112 8-bromo-3',5'-cyclic AMP multiple interactions ISO RGD:735707 6480464 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]] CTD PMID:11230753 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:735707 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL1A mRNA CTD PMID:22079614 acetylsalicylic acid multiple interactions ISO RGD:735707 6480464 [Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; more ... CTD PMID:14742690 afimoxifene decreases expression ISO RGD:735707 6480464 4-hydroxytamoxifen results in decreased expression of IL1A mRNA CTD PMID:23373633 albendazole multiple interactions ISO RGD:735707 6480464 [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 aldehydo-D-glucosamine multiple interactions ISO RGD:2890 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of IL1A mRNA]; more ... CTD PMID:17109745 aldehydo-D-glucosamine increases expression ISO RGD:2890 6480464 Glucosamine results in increased expression of IL1A mRNA CTD PMID:17109745 all-trans-retinoic acid multiple interactions ISO RGD:735707 6480464 Tretinoin inhibits the reaction [IL1A protein results in increased expression of IVL mRNA]; more ... CTD PMID:17214633 all-trans-retinoic acid multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Tretinoin CTD PMID:19362101 all-trans-retinoic acid multiple interactions EXP   6480464 Tretinoin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 all-trans-retinoic acid affects activity ISO RGD:2890 6480464 Tretinoin affects the activity of IL1A protein CTD PMID:16847438 aluminium oxide increases expression ISO RGD:735707 6480464 Aluminum Oxide results in increased expression of IL1A mRNA CTD PMID:15183442 amiodarone multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Amiodarone CTD PMID:19362101 amiodarone increases expression ISO RGD:735707 6480464 Amiodarone results in increased expression of IL1A mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:2890 6480464 Ammonium Chloride affects the expression of IL1A mRNA CTD PMID:16483693 aniline increases expression ISO RGD:2890 6480464 aniline results in increased expression of IL1A mRNA; more ... CTD PMID:15694462 PMID:18420242 aniline increases expression ISO RGD:2890 6480464 aniline results in increased expression of IL1A protein; more ... CTD PMID:18420242 PMID:15694462 anthracene-1,8,9-triol increases expression EXP   6480464 Anthralin results in increased expression of IL1A mRNA CTD PMID:7665919 PMID:8435107 anthracene-1,8,9-triol increases expression EXP   6480464 Anthralin results in increased expression of IL1A mRNA CTD PMID:8435107 PMID:7665919 anthracene-1,8,9-triol multiple interactions EXP   6480464 Plant Extracts inhibits the reaction [Anthralin results in increased expression of IL1A protein]; more ... CTD PMID:7665919 anthracene-1,8,9-triol increases expression EXP   6480464 Anthralin results in increased expression of IL1A protein CTD PMID:7665919 arachidonic acid multiple interactions EXP   6480464 [IL1A protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprostone CTD PMID:11351503 arsenic atom increases expression ISO RGD:735707 6480464 Arsenic results in increased expression of IL1A mRNA CTD PMID:19945496 arsenic atom decreases expression ISO RGD:735707 6480464 Arsenic results in decreased expression of IL1A mRNA CTD PMID:16835338 arsenite(3-) decreases expression ISO RGD:735707 6480464 arsenite results in decreased expression of IL1A mRNA CTD PMID:16085347 arsenite(3-) multiple interactions ISO RGD:735707 6480464 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL1A mRNA] CTD PMID:16085347 asbestos decreases expression ISO RGD:735707 6480464 Asbestos results in decreased expression of IL1A mRNA CTD PMID:22398240 asbestos increases expression ISO RGD:735707 6480464 Asbestos results in increased expression of IL1A mRNA CTD PMID:22398240 azathioprine multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Azathioprine CTD PMID:19362101 BAPTA multiple interactions EXP   6480464 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:9221826 benzbromarone multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Benzbromarone CTD PMID:19362101 benzene affects expression ISO RGD:735707 6480464 Benzene affects the expression of IL1A mRNA CTD PMID:21147609 benzene decreases cleavage EXP   6480464 Benzene results in decreased cleavage of IL1A protein CTD PMID:9118901 benzene increases expression ISO RGD:2890 6480464 Benzene results in increased expression of IL1A protein CTD PMID:15902427 benzene affects response to substance ISO RGD:735707 6480464 IL1A gene SNP affects the susceptibility to Benzene CTD PMID:16230423 benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:19152381 more ... benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:16002475 more ... benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:16002475 more ... benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:17879257 more ... benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:19152381 more ... benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:19152381 more ... benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:20464547 more ... benzo[a]pyrene multiple interactions ISO RGD:735707 6480464 chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1A mRNA] CTD PMID:19152381 benzo[a]pyrene increases expression ISO RGD:735707 6480464 Benzo(a)pyrene results in increased expression of IL1A mRNA CTD PMID:16002475 more ... benzo[a]pyrene multiple interactions ISO RGD:735707 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1A mRNA]; more ... CTD PMID:20464547 benzocaine increases activity EXP   6480464 Benzocaine results in increased activity of IL1A protein CTD PMID:15840424 beta-D-glucosamine multiple interactions ISO RGD:2890 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of IL1A mRNA]; more ... CTD PMID:17109745 beta-D-glucosamine increases expression ISO RGD:2890 6480464 Glucosamine results in increased expression of IL1A mRNA CTD PMID:17109745 bis(2-chloroethyl) sulfide increases expression ISO RGD:735707 6480464 Mustard Gas results in increased expression of IL1A protein CTD PMID:8603935 bis(2-chloroethyl) sulfide increases expression ISO RGD:2890 6480464 Mustard Gas results in increased expression of IL1A protein CTD PMID:18852015 bis(2-chloroethyl) sulfide affects expression ISO RGD:2890 6480464 Mustard Gas affects the expression of IL1A mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide increases expression EXP   6480464 Mustard Gas results in increased expression of IL1A protein CTD PMID:11428647 bisphenol A affects expression ISO RGD:735707 6480464 bisphenol A affects the expression of IL1A mRNA CTD PMID:20170705 bisphenol A multiple interactions ISO RGD:735707 6480464 bisphenol A inhibits the reaction [IL1A protein promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to CCL2 promoter]]; more ... CTD PMID:10614622 cadmium atom multiple interactions ISO RGD:735707 6480464 Cadmium results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 cadmium selenide multiple interactions ISO RGD:735707 6480464 [cadmium selenide co-treated with zinc sulfide] results in increased expression of IL1A mRNA CTD PMID:22342292 cadmium sulfate increases expression ISO RGD:735707 6480464 cadmium sulfate results in increased expression of IL1A mRNA CTD PMID:12064557 calcitriol decreases expression EXP   6480464 Calcitriol results in decreased expression of IL1A protein CTD PMID:2525134 capsaicin multiple interactions ISO RGD:2890 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; more ... CTD PMID:22150557 capsaicin decreases expression ISO RGD:2890 6480464 Capsaicin results in decreased expression of IL1A protein CTD PMID:22150557 carrageenan multiple interactions EXP   6480464 Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; more ... CTD PMID:12182845 carrageenan decreases expression EXP   6480464 Carrageenan results in decreased expression of IL1A protein CTD PMID:12182845 chlorogenic acid decreases expression ISO RGD:735707 6480464 Chlorogenic Acid results in decreased expression of IL1A mRNA CTD PMID:20706672 chloroquine increases expression ISO RGD:735707 6480464 Chloroquine results in increased expression of IL1A CTD PMID:15139008 chlorpromazine multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Chlorpromazine CTD PMID:19362101 ciprofloxacin multiple interactions ISO RGD:735707 6480464 wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 cisplatin increases expression EXP   6480464 Cisplatin results in increased expression of IL1A protein CTD PMID:20844023 clarithromycin multiple interactions ISO RGD:735707 6480464 [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Clarithromycin; more ... CTD PMID:19362101 clarithromycin multiple interactions ISO RGD:2890 6480464 [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Clarithromycin CTD PMID:19362101 clobetasol decreases secretion EXP   6480464 Clobetasol results in decreased secretion of IL1A protein CTD PMID:15086553 clofibrate multiple interactions EXP   6480464 Clofibrate inhibits the reaction [Oxazolone results in increased expression of IL1A protein]; more ... CTD PMID:11851881 clomipramine multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Clomipramine CTD PMID:19362101 clonidine multiple interactions ISO RGD:2890 6480464 Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]; more ... CTD PMID:16192389 clonidine (amino form) multiple interactions ISO RGD:2890 6480464 Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]; more ... CTD PMID:16192389 clonidine (imino form) multiple interactions ISO RGD:2890 6480464 Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]; more ... CTD PMID:16192389 cocaine affects expression ISO RGD:2890 6480464 Cocaine affects the expression of IL1A mRNA CTD PMID:20187946 copper atom multiple interactions ISO RGD:2890 6480464 [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of IL1A mRNA CTD PMID:20302851 copper atom increases secretion ISO RGD:2890 6480464 Copper results in increased secretion of IL1A protein CTD PMID:19635393 copper atom increases secretion EXP   6480464 Copper results in increased secretion of IL1A protein CTD PMID:19635393 copper(0) multiple interactions ISO RGD:2890 6480464 [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of IL1A mRNA CTD PMID:20302851 copper(0) increases secretion ISO RGD:2890 6480464 Copper results in increased secretion of IL1A protein CTD PMID:19635393 copper(0) increases secretion EXP   6480464 Copper results in increased secretion of IL1A protein CTD PMID:19635393 cortisol decreases expression ISO RGD:735707 6480464 Hydrocortisone results in decreased expression of IL1A mRNA CTD PMID:21980503 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein] CTD PMID:18719352 curcumin multiple interactions ISO RGD:2890 6480464 Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein] CTD PMID:19782127 cycloheximide multiple interactions ISO RGD:735707 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of IL1A mRNA CTD PMID:19684285 cycloheximide increases expression ISO RGD:735707 6480464 Cycloheximide results in increased expression of IL1A mRNA CTD PMID:19684285 cyclophosphamide increases expression EXP   6480464 Cyclophosphamide results in increased expression of IL1A mRNA CTD PMID:15331540 cyclophosphamide increases expression ISO RGD:2890 6480464 Cyclophosphamide results in increased expression of IL1A protein CTD PMID:18848347 cyclophosphamide affects response to substance ISO RGD:735707 6480464 IL1A promoter polymorphism affects the susceptibility to Cyclophosphamide CTD PMID:16636934 daidzein multiple interactions EXP   6480464 daidzein inhibits the reaction [Estradiol results in increased expression of IL1A mRNA] CTD PMID:11473722 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:735707 6480464 Tetrahydrocannabinol results in increased expression of IL1A mRNA CTD PMID:16039398 demeclocycline multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 desferrioxamine B multiple interactions ISO RGD:735707 6480464 Deferoxamine inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] CTD PMID:21703343 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; more ... CTD PMID:16880258 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [IL1A protein promotes the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]] CTD PMID:7540993 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; more ... CTD PMID:12182845 diarsenic trioxide decreases expression ISO RGD:735707 6480464 arsenic trioxide results in decreased expression of IL1A mRNA CTD PMID:17530438 diarsenic trioxide increases expression ISO RGD:735707 6480464 arsenic trioxide results in increased expression of IL1A mRNA CTD PMID:22521957 diclofenac multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Diclofenac CTD PMID:19362101 diethylstilbestrol increases expression EXP   6480464 Diethylstilbestrol results in increased expression of IL1A mRNA CTD PMID:15171707 diethylstilbestrol increases expression EXP   6480464 Diethylstilbestrol results in increased expression of IL1A protein CTD PMID:15794588 dimethyl sulfoxide multiple interactions ISO RGD:735707 6480464 Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA] CTD PMID:21878375 dodecane multiple interactions ISO RGD:735707 6480464 n-dodecane results in increased expression of and results in increased secretion of IL1A protein CTD PMID:19720135 enalapril multiple interactions ISO RGD:735707 6480464 Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; more ... CTD PMID:17299153 estriol decreases expression ISO RGD:735707 6480464 Estriol results in decreased expression of IL1A mRNA CTD PMID:10731640 estrone 3-sulfate decreases expression ISO RGD:735707 6480464 estrone sulfate results in decreased expression of IL1A mRNA CTD PMID:10731640 ethidium multiple interactions EXP   6480464 Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein] CTD PMID:10571731 ethidium multiple interactions EXP   6480464 Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956 ferroheme b increases expression EXP   6480464 Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 flufenamic acid multiple interactions ISO RGD:735707 6480464 Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] CTD PMID:10866999 formaldehyde multiple interactions ISO RGD:735707 6480464 Formaldehyde results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 fulvestrant multiple interactions ISO RGD:735707 6480464 fulvestrant inhibits the reaction [Estradiol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; more ... CTD PMID:10614622 furan decreases expression EXP   6480464 furan results in decreased expression of IL1A mRNA CTD PMID:20194422 gadodiamide hydrate increases expression ISO RGD:2890 6480464 gadodiamide results in increased expression of IL1A protein CTD PMID:20938346 gadolinium trichloride multiple interactions ISO RGD:2890 6480464 gadolinium chloride inhibits the reaction [Lindane results in increased expression of IL1A mRNA]; more ... CTD PMID:15025948 gamma-hexachlorocyclohexane multiple interactions ISO RGD:2890 6480464 alpha-Tocopherol inhibits the reaction [Lindane results in increased expression of IL1A mRNA]; more ... CTD PMID:15025948 gamma-hexachlorocyclohexane increases expression ISO RGD:2890 6480464 Lindane results in increased expression of IL1A mRNA; more ... CTD PMID:15025948 genistein multiple interactions EXP   6480464 Genistein inhibits the reaction [Estradiol results in increased expression of IL1A mRNA] CTD PMID:11473722 genistein decreases expression ISO RGD:735707 6480464 Genistein results in decreased expression of IL1A mRNA CTD PMID:20706672 gold atom multiple interactions EXP   6480464 [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein CTD PMID:22155353 gold atom increases secretion EXP   6480464 Gold results in increased secretion of IL1A protein CTD PMID:22155353 gold(0) multiple interactions EXP   6480464 [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein CTD PMID:22155353 gold(0) increases secretion EXP   6480464 Gold results in increased secretion of IL1A protein CTD PMID:22155353 hexadecane multiple interactions ISO RGD:735707 6480464 n-hexadecane results in increased expression of and results in increased secretion of IL1A protein CTD PMID:19720135 hyaluronic acid multiple interactions EXP   6480464 CASP1 gene mutant form inhibits the reaction [Hyaluronic Acid results in increased secretion of IL1A protein]; more ... CTD PMID:23010656 hyaluronic acid increases secretion EXP   6480464 Hyaluronic Acid results in increased secretion of IL1A protein CTD PMID:23010656 hydrogen peroxide increases expression ISO RGD:735707 6480464 Hydrogen Peroxide results in increased expression of IL1A mRNA CTD PMID:11378323 hydroquinone decreases cleavage EXP   6480464 hydroquinone results in decreased cleavage of IL1A protein CTD PMID:9118901 ibuprofen multiple interactions ISO RGD:735707 6480464 Ibuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein] CTD PMID:11230753 ibuprofen increases expression ISO RGD:735707 6480464 Ibuprofen results in increased expression of IL1A mRNA CTD PMID:17070997 indomethacin multiple interactions ISO RGD:735707 6480464 Indomethacin inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein] CTD PMID:11230753 iron atom multiple interactions ISO RGD:2890 6480464 [Iron co-treated with Diethylnitrosamine] results in increased expression of IL1A mRNA; more ... CTD PMID:20302851 isotretinoin decreases secretion ISO RGD:2890 6480464 Isotretinoin results in decreased secretion of IL1A protein CTD PMID:15972972 ivermectin multiple interactions ISO RGD:735707 6480464 [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 kojic acid multiple interactions ISO RGD:2890 6480464 [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1A mRNA CTD PMID:18544905 lenalidomide multiple interactions EXP   6480464 lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA] CTD PMID:16510725 losartan multiple interactions ISO RGD:735707 6480464 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; more ... CTD PMID:17299153 m-xylene increases expression ISO RGD:2890 6480464 3-xylene results in increased expression of IL1A protein CTD PMID:12717741 PMID:15902427 m-xylene increases expression ISO RGD:2890 6480464 3-xylene results in increased expression of IL1A protein CTD PMID:15902427 PMID:12717741 mangiferin decreases expression EXP   6480464 mangiferin results in decreased expression of IL1A mRNA CTD PMID:15135318 melatonin multiple interactions EXP   6480464 Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA] CTD PMID:21461237 melatonin decreases expression EXP   6480464 Melatonin results in decreased expression of IL1A mRNA CTD PMID:21461237 menadione multiple interactions ISO RGD:2890 6480464 Acetaminophen inhibits the reaction [Vitamin K 3 results in increased expression of IL1A mRNA]; more ... CTD PMID:19265712 menadione multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Vitamin K 3 CTD PMID:19362101 menadione increases secretion ISO RGD:2890 6480464 Vitamin K 3 results in increased secretion of IL1A protein CTD PMID:19265712 menadione increases expression ISO RGD:2890 6480464 Vitamin K 3 results in increased expression of IL1A mRNA CTD PMID:19265712 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL1A protein CTD PMID:21984480 methadone increases expression ISO RGD:2890 6480464 Methadone results in increased expression of IL1A protein CTD PMID:20178837 methotrexate increases expression ISO RGD:735707 6480464 Methotrexate results in increased expression of IL1A mRNA CTD PMID:19100307 methotrexate decreases expression ISO RGD:735707 6480464 Methotrexate results in decreased expression of IL1A mRNA CTD PMID:17400583 metoprolol increases expression ISO RGD:735707 6480464 Metoprolol results in increased expression of IL1A mRNA CTD PMID:17467819 metoprolol increases secretion ISO RGD:735707 6480464 Metoprolol results in increased secretion of IL1A protein CTD PMID:17467819 mevalonic acid multiple interactions ISO RGD:735707 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] CTD PMID:15728660 mevalonic acid multiple interactions ISO RGD:2890 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; more ... CTD PMID:15705589 mexiletine multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 mono(2-ethylhexyl) phthalate increases expression ISO RGD:2890 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of IL1A mRNA CTD PMID:16809437 morphine multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; more ... CTD PMID:12182845 morphine decreases expression EXP   6480464 Morphine results in decreased expression of IL1A protein CTD PMID:12182845 muramyl dipeptide increases response to substance EXP   6480464 IL1A protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine CTD PMID:19897531 N-nitrosodiethylamine multiple interactions EXP   6480464 Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]]; more ... CTD PMID:18691550 N-nitrosodiethylamine multiple interactions ISO RGD:2890 6480464 [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA CTD PMID:21295105 N-nitrosodiethylamine multiple interactions ISO RGD:2890 6480464 [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1A mRNA CTD PMID:18544905 N-nitrosodiethylamine multiple interactions ISO RGD:2890 6480464 [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in increased expression of IL1A mRNA; more ... CTD PMID:20302851 N-nitrosodiethylamine increases expression EXP   6480464 Diethylnitrosamine results in increased expression of IL1A protein CTD PMID:18691550 N-nitrosodimethylamine multiple interactions EXP   6480464 CSF3 protein affects the reaction [Dimethylnitrosamine affects the expression of IL1A mRNA] CTD PMID:17869372 N-nitrosodimethylamine affects expression EXP   6480464 Dimethylnitrosamine affects the expression of IL1A mRNA CTD PMID:17869372 naloxone multiple interactions EXP   6480464 Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; more ... CTD PMID:12182845 naproxen multiple interactions ISO RGD:2890 6480464 Naproxen inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; more ... CTD PMID:22150557 nefazodone multiple interactions ISO RGD:735707 6480464 [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to nefazodone CTD PMID:19362101 nefazodone multiple interactions ISO RGD:2890 6480464 [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to nefazodone CTD PMID:19362101 nickel dichloride increases expression ISO RGD:735707 6480464 nickel chloride results in increased expression of IL1A mRNA CTD PMID:11378323 PMID:17312168 nickel dichloride multiple interactions ISO RGD:735707 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1A protein CTD PMID:18437699 nickel sulfate multiple interactions ISO RGD:735707 6480464 IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; more ... CTD PMID:15679580 nickel sulfate increases secretion ISO RGD:735707 6480464 nickel sulfate results in increased secretion of IL1A protein CTD PMID:15679580 nimesulide multiple interactions ISO RGD:735707 6480464 [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to nimesulide CTD PMID:19362101 nitric oxide multiple interactions ISO RGD:735707 6480464 Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; more ... CTD PMID:16968468 nitric oxide multiple interactions ISO RGD:2890 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; more ... CTD PMID:15705589 nitric oxide increases abundance ISO RGD:2890 6480464 IL1A results in increased abundance of Nitric Oxide CTD PMID:15705589 nonanoic acid increases expression EXP   6480464 pelargonic acid results in increased expression of IL1A mRNA CTD PMID:18652873 nortriptyline multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 ozone increases expression EXP   6480464 Ozone results in increased expression of IL1A mRNA CTD PMID:17575079 ozone increases secretion EXP   6480464 Ozone results in increased secretion of IL1A protein CTD PMID:23010656 ozone multiple interactions EXP   6480464 CASP1 gene mutant form inhibits the reaction [Ozone results in increased secretion of IL1A protein]; more ... CTD PMID:23010656 ozone multiple interactions ISO RGD:2890 6480464 TNF protein promotes the reaction [Ozone results in increased expression of IL1A mRNA] CTD PMID:12377989 ozone increases expression ISO RGD:2890 6480464 Ozone results in increased expression of IL1A mRNA CTD PMID:12377989 paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of IL1A mRNA CTD PMID:11826401 more ... paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of IL1A mRNA CTD PMID:11826401 more ... paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of IL1A mRNA CTD PMID:14557383 more ... paracetamol multiple interactions EXP   6480464 TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL1A mRNA] CTD PMID:14557383 paracetamol multiple interactions ISO RGD:2890 6480464 Acetaminophen inhibits the reaction [Vitamin K 3 results in increased expression of IL1A mRNA]; more ... CTD PMID:19265712 paracetamol multiple interactions EXP   6480464 IL1A protein inhibits the reaction [Acetaminophen results in increased expression of CYP3A11 protein]; more ... CTD PMID:19002106 paracetamol multiple interactions EXP   6480464 IFNG protein promotes the reaction [Acetaminophen results in increased expression of IL1A mRNA] CTD PMID:12153990 paracetamol multiple interactions EXP   6480464 IL10 protein affects the reaction [Acetaminophen results in increased expression of IL1A mRNA] CTD PMID:11826401 paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of IL1A mRNA CTD PMID:12153990 more ... paraquat increases expression ISO RGD:735707 6480464 Paraquat results in increased expression of IL1A mRNA CTD PMID:20883675 paraquat increases expression EXP   6480464 Paraquat results in increased expression of IL1A mRNA CTD PMID:22938100 paricalcitol multiple interactions EXP   6480464 [Phosphorus co-treated with paricalcitol] results in increased expression of IL1A mRNA CTD PMID:17715259 phenethyl isothiocyanate multiple interactions EXP   6480464 phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA] CTD PMID:20423518 phenobarbital decreases expression ISO RGD:2890 6480464 Phenobarbital results in decreased expression of IL1A mRNA CTD PMID:19162173 phenol increases secretion ISO RGD:735707 6480464 Phenol results in increased secretion of IL1A protein CTD PMID:16522979 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA]; more ... CTD PMID:8435107 phorbol 13-acetate 12-myristate increases expression EXP   6480464 Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA CTD PMID:7665919 PMID:8435107 phorbol 13-acetate 12-myristate increases expression EXP   6480464 Tetradecanoylphorbol Acetate results in increased expression of IL1A protein CTD PMID:11851881 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A protein] CTD PMID:11851881 phorbol 13-acetate 12-myristate increases expression ISO RGD:735707 6480464 Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA CTD PMID:21045076 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:735707 6480464 SOD2 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:21045076 phorbol 13-acetate 12-myristate increases expression EXP   6480464 Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA CTD PMID:8435107 PMID:7665919 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 epicatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA]; more ... CTD PMID:7665919 phosphorus atom multiple interactions EXP   6480464 [Phosphorus co-treated with paricalcitol] results in increased expression of IL1A mRNA CTD PMID:17715259 phosphorus(.) multiple interactions EXP   6480464 [Phosphorus co-treated with paricalcitol] results in increased expression of IL1A mRNA CTD PMID:17715259 phthalic anhydride increases activity EXP   6480464 phthalic anhydride results in increased activity of IL1A protein CTD PMID:15840424 pirinixic acid decreases expression EXP   6480464 pirinixic acid results in decreased expression of IL1A protein CTD PMID:20131406 polymyxin B2 multiple interactions ISO RGD:735707 6480464 Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] CTD PMID:21703343 potassium dichromate increases secretion ISO RGD:735707 6480464 Potassium Dichromate results in increased secretion of IL1A protein CTD PMID:20619327 potassium dichromate increases expression ISO RGD:735707 6480464 Potassium Dichromate results in increased expression of IL1A mRNA CTD PMID:20619327 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:2890 6480464 Pregnenolone Carbonitrile results in decreased expression of IL1A mRNA CTD PMID:19162173 prostaglandin E2 increases abundance EXP   6480464 IL1A protein results in increased abundance of Dinoprostone CTD PMID:8218930 prostaglandin E2 multiple interactions EXP   6480464 [IL1A protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprostone CTD PMID:11351503 prostaglandin E2 increases abundance ISO RGD:735707 6480464 IL1A protein results in increased abundance of Dinoprostone CTD PMID:21513769 prostaglandin E2 increases secretion ISO RGD:2890 6480464 IL1A protein results in increased secretion of Dinoprostone CTD PMID:16169897 prostaglandin F2alpha increases abundance ISO RGD:735707 6480464 IL1A protein results in increased abundance of Dinoprost CTD PMID:21513769 prostaglandin I2 increases abundance ISO RGD:735707 6480464 IL1A protein results in increased abundance of Epoprostenol CTD PMID:21513769 quercetin multiple interactions ISO RGD:735707 6480464 Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA] CTD PMID:17929310 quercetin 3-O-beta-D-glucoside multiple interactions ISO RGD:2890 6480464 [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA CTD PMID:21295105 quinacrine multiple interactions EXP   6480464 Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 quinine multiple interactions ISO RGD:735707 6480464 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Quinine CTD PMID:19362101 ranitidine multiple interactions ISO RGD:2890 6480464 [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased susceptibility to Ranitidine CTD PMID:19362101 resveratrol multiple interactions ISO RGD:735707 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA] CTD PMID:17929310 resveratrol decreases expression ISO RGD:735707 6480464 resveratrol results in decreased expression of IL1A mRNA CTD PMID:20706672 resveratrol decreases expression EXP   6480464 resveratrol analog results in decreased expression of IL1A mRNA CTD PMID:15652768 rotenone multiple interactions EXP   6480464 Rotenone inhibits the reaction [sodium arsenate results in increased expression of IL1A protein] CTD PMID:10571731 rotenone multiple interactions EXP   6480464 Rotenone inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956 scopolamine decreases response to substance EXP   6480464 IL1A protein results in decreased susceptibility to Scopolamine Hydrobromide CTD PMID:8003924 silicon dioxide multiple interactions EXP   6480464 [Chromium Alloys co-treated with titanium alloy (TiAl6V4) co-treated with titanium nitride co-treated with Silicon Dioxide] results in increased expression of IL1A protein; more ... CTD PMID:12168658 silicon dioxide multiple interactions EXP   6480464 [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein CTD PMID:22155353 silicon dioxide increases expression ISO RGD:735707 6480464 Silicon Dioxide results in increased expression of IL1A mRNA CTD PMID:19428942 silver atom affects expression ISO RGD:735707 6480464 Silver affects the expression of IL1A mRNA CTD PMID:22342292 silver(0) affects expression ISO RGD:735707 6480464 Silver affects the expression of IL1A mRNA CTD PMID:22342292 simvastatin multiple interactions ISO RGD:735707 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; more ... CTD PMID:15728660 simvastatin multiple interactions ISO RGD:2890 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; more ... CTD PMID:15705589 sodium chloride increases expression ISO RGD:735707 6480464 Sodium Chloride results in increased expression of IL1A mRNA CTD PMID:11378323 sodium dichromate increases expression ISO RGD:2890 6480464 sodium bichromate results in increased expression of IL1A protein CTD PMID:22011396 sodium dodecyl sulfate multiple interactions ISO RGD:735707 6480464 IL1A protein affects the reaction [Sodium Dodecyl Sulfate results in increased secretion of CCL20 protein]; more ... CTD PMID:15679580 sodium dodecyl sulfate increases expression ISO RGD:735707 6480464 Sodium Dodecyl Sulfate results in increased expression of IL1A mRNA CTD PMID:11378323 sodium dodecyl sulfate increases secretion ISO RGD:735707 6480464 Sodium Dodecyl Sulfate results in increased secretion of IL1A protein CTD PMID:15679580 sulindac multiple interactions ISO RGD:2890 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL1A mRNA CTD PMID:20371263 sumatriptan multiple interactions ISO RGD:2890 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; more ... CTD PMID:22150557 testosterone affects expression EXP   6480464 Testosterone affects the expression of IL1A protein CTD PMID:20403060 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of IL1A mRNA CTD PMID:18395288 tetrachloromethane multiple interactions EXP   6480464 CD44 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL1A mRNA] CTD PMID:18395288 tetrachloromethane increases expression ISO RGD:2890 6480464 Carbon Tetrachloride results in increased expression of IL1A protein CTD PMID:17904177 tetradecane multiple interactions ISO RGD:735707 6480464 n-tetradecane results in increased expression of and results in increased secretion of IL1A protein CTD PMID:19720135 tetraphene increases expression ISO RGD:735707 6480464 benz(a)anthracene results in increased expression of IL1A mRNA CTD PMID:8156173 tetrathiomolybdate(2-) multiple interactions EXP   6480464 tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] CTD PMID:21724870 titanium dioxide affects expression ISO RGD:735707 6480464 titanium dioxide affects the expression of IL1A mRNA CTD PMID:19695317 titanium dioxide affects expression ISO RGD:735707 6480464 titanium dioxide affects the expression of IL1A mRNA CTD PMID:19695317 PMID:22342292 toluene 2,4-diisocyanate multiple interactions EXP   6480464 IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; more ... CTD PMID:16210060 toluene 2,4-diisocyanate increases secretion ISO RGD:735707 6480464 Toluene 2,4-Diisocyanate results in increased secretion of IL1A protein CTD PMID:1699434 toremifene multiple interactions EXP   6480464 Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; more ... CTD PMID:12079510 trans-resveratrol multiple interactions ISO RGD:735707 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA] CTD PMID:17929310 trans-resveratrol decreases expression ISO RGD:735707 6480464 resveratrol results in decreased expression of IL1A mRNA CTD PMID:20706672 trans-resveratrol decreases expression EXP   6480464 resveratrol analog results in decreased expression of IL1A mRNA CTD PMID:15652768 tributylstannane multiple interactions EXP   6480464 Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein]; more ... CTD PMID:8875956 tributylstannane increases expression EXP   6480464 tributyltin results in increased expression of IL1A protein CTD PMID:9221826 PMID:8875956 tributylstannane multiple interactions EXP   6480464 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:9221826 tributylstannane increases expression EXP   6480464 tributyltin results in increased expression of IL1A protein CTD PMID:8875956 PMID:9221826 tridecane multiple interactions ISO RGD:735707 6480464 tridecane results in increased expression of and results in increased secretion of IL1A protein CTD PMID:19720135 trimethyltin increases expression EXP   6480464 trimethyltin results in increased expression of IL1A mRNA CTD PMID:20833246 PMID:21435392 troglitazone decreases expression ISO RGD:735707 6480464 troglitazone results in decreased expression of IL1A mRNA CTD PMID:19631733 urethane multiple interactions ISO RGD:735707 6480464 Urethane results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 valproic acid affects expression EXP   6480464 Valproic Acid affects the expression of IL1A mRNA CTD PMID:17292431 vanadium atom increases expression ISO RGD:2890 6480464 Vanadium results in increased expression of IL1A mRNA CTD PMID:15159208 vanadium(0) increases expression ISO RGD:2890 6480464 Vanadium results in increased expression of IL1A mRNA CTD PMID:15159208 vanadyl sulfate increases expression ISO RGD:735707 6480464 vanadyl sulfate results in increased expression of IL1A mRNA CTD PMID:16330358 wortmannin multiple interactions ISO RGD:735707 6480464 wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 zidovudine increases expression ISO RGD:735707 6480464 Zidovudine results in increased expression of IL1A protein CTD PMID:7979221 zinc atom increases expression ISO RGD:2890 6480464 Zinc results in increased expression of IL1A mRNA CTD PMID:15159208 zinc atom multiple interactions ISO RGD:2890 6480464 [Zinc deficiency co-treated with IL1A protein] results in increased expression of NOS2 mRNA; more ... CTD PMID:12514266 zinc atom multiple interactions ISO RGD:735707 6480464 Zinc promotes the reaction [IL1A protein results in increased expression of MT2A mRNA] CTD PMID:1502195 zinc atom increases uptake ISO RGD:735707 6480464 IL1A protein results in increased uptake of Zinc CTD PMID:1502195 zinc atom affects metabolic processing ISO RGD:735707 6480464 IL1A protein affects the metabolism of Zinc CTD PMID:2458983 zinc atom multiple interactions ISO RGD:2890 6480464 IL1A protein inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA] CTD PMID:9278552 PMID:9649590 zinc atom multiple interactions ISO RGD:2890 6480464 [IL1A protein co-treated with Zinc deficiency] results in increased expression of NOS2 protein; more ... CTD PMID:9278552 zinc atom increases abundance ISO RGD:735707 6480464 IL1A protein results in increased abundance of Zinc CTD PMID:9278552 zinc dichloride multiple interactions EXP   6480464 NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; more ... CTD PMID:18509044 zinc dichloride increases expression EXP   6480464 zinc chloride results in increased expression of IL1A protein CTD PMID:18509044 zinc sulfate multiple interactions ISO RGD:735707 6480464 IL1A protein promotes the reaction [Zinc Sulfate results in increased expression of MT1G mRNA]; more ... CTD PMID:22722935 zinc sulfate decreases expression ISO RGD:735707 6480464 Zinc Sulfate results in decreased expression of IL1A mRNA CTD PMID:22722935 zinc(0) increases expression ISO RGD:2890 6480464 Zinc results in increased expression of IL1A mRNA CTD PMID:15159208 zinc(0) increases abundance ISO RGD:735707 6480464 IL1A protein results in increased abundance of Zinc CTD PMID:9278552 zinc(0) multiple interactions ISO RGD:2890 6480464 [IL1A protein co-treated with Zinc deficiency] results in increased expression of NOS2 protein; more ... CTD PMID:9278552 zinc(0) multiple interactions ISO RGD:2890 6480464 IL1A protein inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA] CTD PMID:9278552 PMID:9649590 zinc(0) affects metabolic processing ISO RGD:735707 6480464 IL1A protein affects the metabolism of Zinc CTD PMID:2458983 zinc(0) increases uptake ISO RGD:735707 6480464 IL1A protein results in increased uptake of Zinc CTD PMID:1502195 zinc(0) multiple interactions ISO RGD:735707 6480464 Zinc promotes the reaction [IL1A protein results in increased expression of MT2A mRNA] CTD PMID:1502195 zinc(0) multiple interactions ISO RGD:2890 6480464 [Zinc deficiency co-treated with IL1A protein] results in increased expression of NOS2 mRNA; more ... CTD PMID:12514266 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cellular response to heat   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cytokine-mediated signaling pathway   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 fever generation   IEA UniProtKB-KW:KW-0666 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 immune response   IEA InterPro:IPR003502|InterPro:IPR003295|InterPro:IPR003294 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 inflammatory response   IEA InterPro:IPR003502|InterPro:IPR003295|InterPro:IPR003294 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 inflammatory response   IEA UniProtKB-KW:KW-0395 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 keratinization   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of cell proliferation   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of angiogenesis   IMP   2290270 MGI:MGI:2652930|PMID:12598651 BHF-UCL MGI:MGI:2652930 PMID:12598651 positive regulation of cell division   IEA UniProtKB-KW:KW-0497 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 positive regulation of cytokine secretion   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of ERK1 and ERK2 cascade   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of I-kappaB kinase/NF-kappaB cascade   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of interleukin-2 biosynthetic process   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of interleukin-6 production   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of JNK cascade   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of mitosis   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of steroid biosynthetic process   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of stress-activated MAPK cascade   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of transcription from RNA polymerase II promoter   IGI MGI:MGI:96543|MGI:MGI:1932410 2290270 MGI:MGI:4355633|PMID:19666510 MGI MGI:MGI:4355633 PMID:19666510 positive regulation of transcription from RNA polymerase II promoter   IGI MGI:MGI:107364|MGI:MGI:96543 2290270 MGI:MGI:4355633|PMID:19666510 MGI MGI:MGI:4355633 PMID:19666510 positive regulation of transcription from RNA polymerase II promoter   IGI MGI:MGI:96543|MGI:MGI:1890474 2290270 MGI:MGI:4355633|PMID:19666510 MGI MGI:MGI:4355633 PMID:19666510 positive regulation vascular endothelial growth factor production   IMP   2290270 MGI:MGI:2652930|PMID:12598651 BHF-UCL MGI:MGI:2652930 PMID:12598651 regulation of sensory perception of pain   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 response to copper ion   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell surface   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytosol   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 extracellular region   IEA UniProtKB-KW:KW-0964 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 extracellular region   IEA InterPro:IPR003295|InterPro:IPR003294 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 extracellular space   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 extracellular space   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) copper ion binding   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cytokine activity   ISO UniProtKB:P16598 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytokine activity   ISO UniProtKB:P01583 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 interleukin-1 receptor binding   IEA InterPro:IPR003502|InterPro:IPR003295|InterPro:IPR003294 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) apoptotic cell death pathway   IEA RGD:10789 6907045   KEGG mmu:04210 graft-versus-host disease pathway   IEA RGD:10789 6907045   KEGG mmu:05332 influenza A virus infection pathway   IEA RGD:10789 6907045   KEGG mmu:05164 interleukin-1 signaling pathway   ISS RGD:735707 5490209   RGD   interleukin-1 signaling pathway   ISO RGD:735707 6484113   PID PID:200089 Leishmania infection pathway   IEA RGD:10789 6907045   KEGG mmu:05140 measles infection pathway   IEA RGD:10789 6907045   KEGG mmu:05162 mitogen activated protein kinase signaling pathway   IEA RGD:10789 6907045   KEGG mmu:04010 Mycobacterium tuberculosis infection pathway   IEA RGD:10789 6907045   KEGG mmu:05152 prion diseases pathway   IEA RGD:10789 6907045   KEGG mmu:05020 rheumatoid arthritis pathway   IEA RGD:10789 6907045   KEGG mmu:05323 type 1 diabetes mellitus pathway   IEA RGD:10789 6907045   KEGG mmu:04940 External Database Links KEGG Pathway Apoptosis Cytokine-cytokine receptor interaction Graft-versus-host disease Hematopoietic cell lineage Influenza A Leishmaniasis MAPK signaling pathway Measles Osteoclast differentiation Pertussis Prion diseases Rheumatoid arthritis Salmonella infection Tuberculosis Type I diabetes mellitus Pathway Interaction Database a6b1 and a6b4 Integrin signaling (PID:200190) IL1-mediated signaling events (PID:200089) Validated transcriptional targets of deltaNp63 isoforms (PID:200186) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal inflammatory response   IAGP   5509061   MGI PMID:23219391 abnormal tumor vascularization   IAGP   5509061   MGI PMID:12598651 decreased circulating corticosterone level   IAGP   5509061   MGI PMID:9565638 decreased circulating interleukin-1 alpha level   IAGP   5509061   MGI PMID:9565638 decreased circulating interleukin-1 beta level   IAGP   5509061   MGI PMID:9565638 decreased interleukin-1 beta secretion   IAGP   5509061   MGI PMID:9565638 decreased metastatic potential   IAGP   5509061   MGI PMID:12598651 decreased susceptibility to experimental autoimmune encephalomyelitis   IAGP   5509061   MGI PMID:20937871 decreased susceptibility to type IV hypersensitivity reaction   IAGP   5509061   MGI PMID:20937871 impaired febrile response   IAGP   5509061   MGI PMID:9565638 impaired neutrophil recruitment   IAGP   5509061   MGI PMID:9809553 increased neutrophil cell number   IAGP   5509061   MGI PMID:23219391 Disease Annotations Acute Kidney Injury  (IPM) Alveolitis, Extrinsic Allergic  (IEP) Alzheimer Disease  (ISS) Arthritis, Experimental  (ISS) Arthritis, Rheumatoid  (ISS) Asthma  (ISS) Brain Injuries  (ISS) Carcinoma, Non-Small-Cell Lung  (ISS) Cholestasis  (ISS) Common Cold  (ISS) Cystic Fibrosis  (ISS) Diabetes Mellitus, Experimental  (ISS) Diabetes Mellitus, Type 1  (IEP,ISS) Diabetic Retinopathy  (ISS) Endotoxemia  (IEP) Fabry Disease  (ISS) Femoral Fractures  (ISS) Fetal Growth Retardation  (ISS) Glomerulonephritis  (IEP) Glomerulonephritis, IGA  (ISS) Heat Stroke  (ISS) Hyperglycemia  (ISS) Influenza, Human  (IEP) Kidney Failure, Chronic  (ISS) Lung Diseases  (IEP,ISS) Lung Diseases, Interstitial  (ISS) Nasal Polyps  (ISS) Osteoporosis  (ISS) Otitis Media  (ISS) Pancreatic Neoplasms  (ISS) Periodontitis  (ISS) Pneumonia, Aspiration  (ISS) Pulmonary Fibrosis  (ISS) Radiation Pneumonitis  (ISS) Reperfusion Injury  (ISS) Respiratory Hypersensitivity  (IPM) Rhinitis, Allergic, Perennial  (ISS) Sclerosis  (ISS) Shock, Hemorrhagic  (ISS) Tuberculosis, Pulmonary  (IEP) Urinary Tract Infections  (IEP,ISS) Varicocele  (ISS) Venous Thrombosis  (ISS) Wounds and Injuries  (ISS) Gene-Chemical Interaction Annotations (+)-alpha-tocopherol  (ISO) (-)-epigallocatechin 3-gallate  (EXP,ISO) (R)-mevalonic acid  (ISO) (S)-nicotine  (ISO) 1,3-dinitrobenzene  (ISO) 1-chloro-2,4-dinitrobenzene  (EXP) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO) 17beta-estradiol  (EXP,ISO) 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]  (ISO) 2,2,2-trichloroethanol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2,4-dinitrotoluene  (ISO) 2,6-di-tert-butyl-4-methylphenol  (EXP) 2-amino-2-deoxy-D-glucopyranose  (ISO) 2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO) 3-methylcholanthrene  (ISO) 3H-1,2-dithiole-3-thione  (ISO) 4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP) 4-hydroxynon-2-enal  (EXP) 4-hydroxyphenyl retinamide  (EXP) 8-bromo-3',5'-cyclic AMP  (ISO) acetylsalicylic acid  (ISO) afimoxifene  (ISO) albendazole  (ISO) aldehydo-D-glucosamine  (ISO) all-trans-retinoic acid  (EXP,ISO) aluminium oxide  (ISO) amiodarone  (ISO) ammonium chloride  (ISO) aniline  (ISO) anthracene-1,8,9-triol  (EXP) arachidonic acid  (EXP) arsenic atom  (ISO) arsenite(3-)  (ISO) asbestos  (ISO) azathioprine  (ISO) BAPTA  (EXP) benzbromarone  (ISO) benzene  (EXP,ISO) benzo[a]pyrene  (ISO) benzocaine  (EXP) beta-D-glucosamine  (ISO) bis(2-chloroethyl) sulfide  (EXP,ISO) bisphenol A  (ISO) cadmium atom  (ISO) cadmium selenide  (ISO) cadmium sulfate  (ISO) calcitriol  (EXP) capsaicin  (ISO) carrageenan  (EXP) chlorogenic acid  (ISO) chloroquine  (ISO) chlorpromazine  (ISO) ciprofloxacin  (ISO) cisplatin  (EXP) clarithromycin  (ISO) clobetasol  (EXP) clofibrate  (EXP) clomipramine  (ISO) clonidine  (ISO) clonidine (amino form)  (ISO) clonidine (imino form)  (ISO) cocaine  (ISO) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) cortisol  (ISO) curcumin  (EXP,ISO) cycloheximide  (ISO) cyclophosphamide  (EXP,ISO) daidzein  (EXP) Delta(9)-tetrahydrocannabinol  (ISO) demeclocycline  (ISO) desferrioxamine B  (ISO) dexamethasone  (EXP) diarsenic trioxide  (ISO) diclofenac  (ISO) diethylstilbestrol  (EXP) dimethyl sulfoxide  (ISO) dodecane  (ISO) enalapril  (ISO) estriol  (ISO) estrone 3-sulfate  (ISO) ethidium  (EXP) ferroheme b  (EXP) flufenamic acid  (ISO) formaldehyde  (ISO) fulvestrant  (ISO) furan  (EXP) gadodiamide hydrate  (ISO) gadolinium trichloride  (ISO) gamma-hexachlorocyclohexane  (ISO) genistein  (EXP,ISO) gold atom  (EXP) gold(0)  (EXP) hexadecane  (ISO) hyaluronic acid  (EXP) hydrogen peroxide  (ISO) hydroquinone  (EXP) ibuprofen  (ISO) indomethacin  (ISO) iron atom  (ISO) isotretinoin  (ISO) ivermectin  (ISO) kojic acid  (ISO) lenalidomide  (EXP) losartan  (ISO) m-xylene  (ISO) mangiferin  (EXP) melatonin  (EXP) menadione  (ISO) mercury dichloride  (EXP) methadone  (ISO) methotrexate  (ISO) metoprolol  (ISO) mevalonic acid  (ISO) mexiletine  (ISO) mono(2-ethylhexyl) phthalate  (ISO) morphine  (EXP) muramyl dipeptide  (EXP) N-nitrosodiethylamine  (EXP,ISO) N-nitrosodimethylamine  (EXP) naloxone  (EXP) naproxen  (ISO) nefazodone  (ISO) nickel dichloride  (ISO) nickel sulfate  (ISO) nimesulide  (ISO) nitric oxide  (ISO) nonanoic acid  (EXP) nortriptyline  (ISO) ozone  (EXP,ISO) paracetamol  (EXP,ISO) paraquat  (EXP,ISO) paricalcitol  (EXP) phenethyl isothiocyanate  (EXP) phenobarbital  (ISO) phenol  (ISO) phorbol 13-acetate 12-myristate  (EXP,ISO) phosphorus atom  (EXP) phosphorus(.)  (EXP) phthalic anhydride  (EXP) pirinixic acid  (EXP) polymyxin B2  (ISO) potassium dichromate  (ISO) pregnenolone 16alpha-carbonitrile  (ISO) prostaglandin E2  (EXP,ISO) prostaglandin F2alpha  (ISO) prostaglandin I2  (ISO) quercetin  (ISO) quercetin 3-O-beta-D-glucoside  (ISO) quinacrine  (EXP) quinine  (ISO) ranitidine  (ISO) resveratrol  (EXP,ISO) rotenone  (EXP) scopolamine  (EXP) silicon dioxide  (EXP,ISO) silver atom  (ISO) silver(0)  (ISO) simvastatin  (ISO) sodium chloride  (ISO) sodium dichromate  (ISO) sodium dodecyl sulfate  (ISO) sulindac  (ISO) sumatriptan  (ISO) testosterone  (EXP) tetrachloromethane  (EXP,ISO) tetradecane  (ISO) tetraphene  (ISO) tetrathiomolybdate(2-)  (EXP) titanium dioxide  (ISO) toluene 2,4-diisocyanate  (EXP,ISO) toremifene  (EXP) trans-resveratrol  (EXP,ISO) tributylstannane  (EXP) tridecane  (ISO) trimethyltin  (EXP) troglitazone  (ISO) urethane  (ISO) valproic acid  (EXP) vanadium atom  (ISO) vanadium(0)  (ISO) vanadyl sulfate  (ISO) wortmannin  (ISO) zidovudine  (ISO) zinc atom  (ISO) zinc dichloride  (EXP) zinc sulfate  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process cellular response to heat  (ISO) cytokine-mediated signaling pathway  (ISO) fever generation  (IEA) immune response  (IEA) inflammatory response  (IEA) keratinization  (ISO) negative regulation of cell proliferation  (ISO) positive regulation of angiogenesis  (IMP) positive regulation of cell division  (IEA) positive regulation of cytokine secretion  (ISO) positive regulation of ERK1 and ERK2 cascade  (ISO) positive regulation of I-kappaB kinase/NF-kappaB cascade  (ISO) positive regulation of interleukin-2 biosynthetic process  (ISO) positive regulation of interleukin-6 production  (ISO) positive regulation of JNK cascade  (ISO) positive regulation of mitosis  (ISO) positive regulation of steroid biosynthetic process  (ISO) positive regulation of stress-activated MAPK cascade  (ISO) positive regulation of transcription from RNA polymerase II promoter  (IGI) positive regulation vascular endothelial growth factor production  (IMP) regulation of sensory perception of pain  (ISO) response to copper ion  (ISO) Cellular Component cell surface  (ISO) cytosol  (ISO) extracellular region  (IEA) extracellular space  (ISO) Molecular Function copper ion binding  (ISO) cytokine activity  (ISO) interleukin-1 receptor binding  (IEA) Molecular Pathway Annotations apoptotic cell death pathway  (IEA) graft-versus-host disease pathway  (IEA) influenza A virus infection pathway  (IEA) interleukin-1 signaling pathway  (ISO,ISS) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) mitogen activated protein kinase signaling pathway  (IEA) Mycobacterium tuberculosis infection pathway  (IEA) prion diseases pathway  (IEA) rheumatoid arthritis pathway  (IEA) type 1 diabetes mellitus pathway  (IEA) External Database Links KEGG Pathway Apoptosis Cytokine-cytokine receptor interaction Graft-versus-host disease Hematopoietic cell lineage Influenza A Leishmaniasis MAPK signaling pathway Measles Osteoclast differentiation Pertussis Prion diseases Rheumatoid arthritis Salmonella infection Tuberculosis Type I diabetes mellitus Pathway Interaction Database a6b1 and a6b4 Integrin signaling (PID:200190) IL1-mediated signaling events (PID:200089) Validated transcriptional targets of deltaNp63 isoforms (PID:200186) Phenotype Annotations abnormal inflammatory response  (IAGP) abnormal tumor vascularization  (IAGP) decreased circulating corticosterone level  (IAGP) decreased circulating interleukin-1 alpha level  (IAGP) decreased circulating interleukin-1 beta level  (IAGP) decreased interleukin-1 beta secretion  (IAGP) decreased metastatic potential  (IAGP) decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP) decreased susceptibility to type IV hypersensitivity reaction  (IAGP) impaired febrile response  (IAGP) impaired neutrophil recruitment  (IAGP) increased neutrophil cell number  (IAGP) References - curated 1. Anaya-Prado R, etal., J Trauma. 2004 Nov;57(5):980-8. 2. Appel JZ 3rd, etal., Respir Res. 2007 Nov 27;8:87. 3. Asada K, etal., Tokushima J Exp Med. 1996 Dec;43(3-4):79-86. 4. Basso D, etal., Int J Clin Lab Res. 1995;25(1):40-3. 5. Bensen JT, etal., Genomics. 2003 Aug;82(2):194-217. 6. Bensen JT, etal., Kidney Int. 2003 Apr;63(4):1211-9. 7. Bhalla DK, etal., Toxicol Sci. 2002 Oct;69(2):400-8. 8. Bohmova K, etal., Scand J Immunol. 2007 Nov;66(5):563-71. 9. Braosi AP, etal., Cytokine. 2012 Oct;60(1):76-82. Epub 2012 Jul 13. 10. Buckham TA, etal., Am J Nephrol. 2010;32(2):103-8. Epub 2010 Jun 16. 11. Cantatore FP, etal., J Rheumatol. 1999 Nov;26(11):2318-23. 12. Chen Y, etal., Semin Radiat Oncol. 2002 Jan;12(1 Suppl 1):26-33. 13. Coban S, etal., J Surg Res. 2008 Nov 24. 14. Eisenberg SP, etal., Proc Natl Acad Sci U S A 1991 Jun 15;88(12):5232-6. 15. Erbek SS, etal., Arch Otolaryngol Head Neck Surg. 2007 Jul;133(7):705-9. 16. Gorgi Y, etal., Tunis Med. 2010 Nov;88(11):789-93. 17. 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Epub 2011 Jun 1. 32. Lin XJ, etal., Shock. 2009 Nov;32(5):524-9. 33. Lowell CA and Berton G, Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7580-4. 34. Lu KT, etal., Neurosci Lett. 2005 Sep 23;386(1):40-5. 35. Mahdaviani SA, etal., J Clin Immunol. 2009 Jan;29(1):57-62. Epub 2008 Sep 2. 36. Maniwa K, etal., Respirology. 2000 Dec;5(4):315-20. 37. MGD and Homologene mouse data transfer 38. MGD data from the GO Consortium 39. MGD IEA 40. Nakae S, etal., Int Immunol. 2003 Apr;15(4):483-90. 41. Nicoll JA, etal., Ann Neurol 2000 Mar;47(3):365-8. 42. O'Shaughnessy RF, etal., Hum Mol Genet. 2010 Jul 1;19(13):2594-605. Epub 2010 Apr 12. 43. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 44. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 45. Pirnik Z, etal., Cell Mol Neurobiol. 2009 Sep;29(6-7):951-60. Epub 2009 Mar 13. 46. Rabinovitch A, etal., Endocrinology. 1996 May;137(5):2093-9. 47. Reverter JL, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1378-82. Epub 2008 Oct 31. 48. Reyes L, etal., BMC Infect Dis. 2009 Jan 26;9:9. 49. RGD automated import pipeline 50. RGD automated import pipeline for gene-chemical interactions 51. Rosa JS, etal., Pediatr Diabetes. 2008 Feb;9(1):9-16. 52. Safyan R, etal., Eur Cytokine Netw. 2006 Dec;17(4):271-5. 53. Sahin Z, etal., Fertil Steril. 2006 Apr;85 Suppl 1:1265-75. 54. Schuyler M, etal., J Lab Clin Med. 2000 Jul;136(1):29-38. 55. Sears BW, etal., J Inflamm Res. 2010 Aug 1;2010(3):105-114. 56. Setoguchi C, etal., Mod Rheumatol. 2010 Aug;20(4):381-8. Epub 2010 Apr 9. 57. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18. 58. Sinniah R, etal., Int J Exp Pathol. 1999 Apr;80(2):87-95. 59. Tong HH, etal., Int J Pediatr Otorhinolaryngol. 2008 Aug;72(8):1183-91. Epub 2008 Jun 3. 60. Van Dyke AL, etal., Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1829-40. 61. 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References - uncurated PubMed 10226804   10349636   10452974   10622417   10651053   10744718   10830786   11042159   11076861   11217851   11342576   11418636   11466424   11518254   11536012   11698278   11717188   11754748   11773602   11809690   11840457   11871152   11883745   11899425   11959104   11988319   11991723   12010793   12012430   12070778   12102659   12112371   12151598   12193704   12270723   12466851   12477932   12598651   12799211   1284644   12878687   12975454   1349539   1353383   1362103   1371115   1421760   14612453   14634130   14662844   14744933   14966082   15232066   15271886   1531270   15314695   15331419   1533388   15381720   15489334   1552283   1552482   15549727   15591249   15613243   15684062   1572101   1577194   15922486   16026578   16046471   1611993   16137777   16141072   16141073   16141396   16256210   16415102   1649220   16517748   16565512   16567518   16569679   16619190   16670337   1672162   16825293   1685143   1686838   16936270   17123788   17173923   17227914   17277081   17283139   17307724   17360358   17446350   17507369   17548042   17569781   17592750   17609389   17919942   17967442   17982084   18086816   18195026   18204848   18234967   1828262   18311808   18434191   18490713   18516292   18596024   18615110   18691550   18778283   18805969   18939951   19050234   19101514   19164472   19216058   19247983   19261731   19342666   19430902   19464323   19513570   19561099   19571816   19576795   19625606   19666510   19703244   1970329   1970330   19720838   19839011   19853894   19926874   20108252   20110570   20133797   20181656   20194588   20200351   20220089   20428172   20513002   20679512   20727790   20937871   20956342   20974980   21093494   21107352   21191074   21219852   21653679   2166945   21677750   21722729   21777484   21828249   21930960   22006336   22058415   22096246   22101928   22143786   22163019   22206014   22206506   22216303   22236482   22291094   22328525   22387558   22444631   22483094   2267629   22682244   22802353   22914048   22972933   23029241   23112187   23219391   2419912   2466396   2613234   2759422   2889668   3022289   3126184   3149717   6209582   7476020   7539003   7579389   7752808   7819439   7826951   7848516   7873879   7902327   7958862   7959775   8001745   8012118   8027056   8031998   8051414   8138038   8177505   8207122   8207237   8224251   8231109   8260598   8268655   8283046   8288218   8306498   8327661   8352883   8432536   8449520   8462855   8464030   8482578   8524866   8543912   8578682   8630372   8699818   8751373   8770556   8798439   8816919   8818542   8833235   8838580   8854867   8881659   8920166   8932996   8953518   9344502   9565638   9809553   9854157   9886396 RGD Disease Portals Il1a has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data Il1a   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 129,299,610 - 129,309,972 - NCBI Mouse cM Map 2 62.9   NCBI Mouse Celera Assembly 2 130,527,298 - 130,537,642 - NCBI Mouse Genome Assembly Build 37 2 129,125,346 - 129,135,708 - NCBI Mouse Genome Assembly Build 36.1 2 129,125,346 - 129,135,708 - NCBI Mouse Cytogenetic Map 2 F   NCBI IL1A   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 2 113,045,348 - 113,056,415 - NCBI Human Genome Assembly HuRef 2 105,986,068 - 105,997,547 - NCBI Human Genome Assembly GRCh37 2 113,531,492 - 113,542,971 - NCBI Human Genome Assembly Build 36 2 113,247,963 - 113,259,442 - NCBI Human Cytogenetic Map 2 q14   NCBI Human Genome Assembly 2 113,247,723 - 113,259,202   NCBI Il1a   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 3 q36   NCBI RGSC Genome Assembly v5.0 3 128,180,475 - 128,190,980 + NCBI RGSC Genome Assembly v3.4 3 116,913,612 - 116,924,114 - NCBI Rat Celera Assembly 3 115,352,857 - 115,362,929 - NCBI Genome Assembly 3.1 3 116,819,184 - 116,829,687 - NCBI Position Markers X01450   Map Chr Position Strand Source Mouse Whitehead_YAC 2     UniSTS Mouse Whitehead/MRC_RH 2 1595.87   UniSTS Mouse cM Map 2 73.0   UniSTS Mouse Celera Assembly 2 130,527,388 - 130,527,559   UniSTS Mouse Genome Assembly Build 37 2 129,126,065 - 129,126,199   UniSTS Mouse Cytogenetic Map 2 F   UniSTS PMC20149P2   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 129,300,159 - 129,300,314   UniSTS Mouse cM Map 2 73.0   UniSTS Mouse Celera Assembly 2 130,527,847 - 130,528,002   UniSTS Mouse Genome Assembly Build 37 2 129,125,895 - 129,126,050   UniSTS Mouse Cytogenetic Map 2 F   UniSTS Il1a   Map Chr Position Strand Source Mouse cM Map 2 73.0   UniSTS Mouse Cytogenetic Map 2 F   UniSTS Il1a   Map Chr Position Strand Source Mouse Cytogenetic Map 2 F   UniSTS Il1a   Map Chr Position Strand Source Mouse Cytogenetic Map 2 F   UniSTS X01450   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 129,300,329 - 129,300,463   UniSTS Mouse Whitehead/MRC_RH 2 1595.87   UniSTS Mouse Celera Assembly 2 130,528,017 - 130,528,151   UniSTS Mouse Genome Assembly Build 37 2 129,126,065 - 129,126,199   UniSTS Mouse Cytogenetic Map 2 F   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 4141854 T2dm2sa_m type 2 diabetes mellitus 2 in SMXA RI mice (mouse) Not determined 2 29273455 148358750 Mouse 1300871 Mob5_m multigenic obesity 5 (mouse) Not determined 2 65277459 162502742 Mouse 5491197 Mobq5_m multigenic obesity QTL 5 (mouse) Not determined 2 65277459 162502742 Mouse 4141155 Plast2b_m plasma plant sterol 2b (mouse) Not determined 2 84023011 148505991 Mouse 1301881 Trmq2_m T cell ratio modifier QTL 2 (mouse) Not determined 2 96285212 130285335 Mouse 1301048 Actre2_m activity response to ethanol 2 (mouse) Not determined 2 97118625 131118787 Mouse 1558825 Aabpr_m aberrant activation of B cell proliferation (mouse) Not determined 2 99028484 133028676 Mouse 4141802 Ignpq1_m IgA nephropathy QTL 1 (mouse) Not determined 2 100819315 134819524 Mouse 1302047 Fubi1_m failure of ureteric bud invasion 1 (mouse) Not determined 2 100819315 134819524 Mouse 1301179 Fembm4_m femoral bone morphometry 4 (mouse) Not determined 2 100819315 134819524 Mouse 1302071 Fembrs1_m femur breaking strength 1 (mouse) Not determined 2 100938185 134938345 Mouse 1301330 Tbbmd2_m total body bone mineral density 2 (mouse) Not determined 2 100938185 134938345 Mouse 1300840 Cdcs3_m cytokine deficiency colitis susceptibility 3 (mouse) Not determined 2 100938185 134938345 Mouse 1302203 Gvhd3_m graft-versus host disease 3 (mouse) Not determined 2 100938185 134938345 Mouse 1301415 Actre4_m activity response to ethanol 4 (mouse) Not determined 2 101267803 135267939 Mouse 4141386 Lctlp1_m lymph node cytotoxic T lymphocyte percentage 1 (mouse) Not determined 2 105652363 139652481 Mouse 1300838 Orgwq3_m organ weight QTL 3 (mouse) Not determined 2 106215789 140215931 Mouse 1301825 Pbrgcsf1_m peripheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse) Not determined 2 106217396 140217545 Mouse 4142058 Ctrq1_m C. trachomatis resistance QTL 1 (mouse) Not determined 2 106255831 140256107 Mouse 1357577 Trmq3_m T cell ratio modifier QTL 3 (mouse) Not determined 2 108551330 142551474 Mouse 1301075 Obq10_m obesity QTL 10 (mouse) Not determined 2 110941410 144941504 Mouse 1301755 Hrq1_m heart rate quantitative locus 1 (mouse) Not determined 2 111157520 145157637 Mouse 1300793 Pcfm2_m periosteal circumference and femur length 2 (mouse) Not determined 2 111157520 145157637 Mouse 1558744 Salpa1_m serum alkaline phosphatase activity 1 (mouse) Not determined 2 111157520 145157637 Mouse 4141405 Elda3_m ethanol induced low dose activation 3 (mouse) Not determined 2 111157520 145157637 Mouse 1301905 Lgth2_m body length 2 (mouse) Not determined 2 111157520 145157637 Mouse 1301201 Chab1_m cholesterol absorption 1 (mouse) Not determined 2 111534844 145534979 Mouse 1302033 Nsv1_m Neuroadapted Sindbis viral RNA level 1 (mouse) Not determined 2 111607202 145607342 Mouse 1300699 Daq18_m directional asymmetry QTL 18 (mouse) Not determined 2 112114208 146114321 Mouse 1301587 Rrodp2_m rotarod performance 2 (mouse) Not determined 2 112114208 146114321 Mouse 1301374 Cplaq7_m circadian period of locomotor activity 7 (mouse) Not determined 2 112114208 146114321 Mouse 1300852 Lmr14_m leishmaniasis resistance 14 (mouse) Not determined 2 112196562 146196821 Mouse 4141895 Dbmc1_m diabetes mRNA cluster 1 (mouse) Not determined 2 115697824 149697973 Mouse 1301295 Prdt1_m prion disease incubation time 1 (mouse) Not determined 2 116061439 150061557 Mouse 1558881 Ses7_m salmonella enteritidis susceptibility 7 (mouse) Not determined 2 116290146 150290290 Mouse 1301588 Hrec_m hemotopoietic response to early cytokines (mouse) Not determined 2 116907759 150907953 Mouse 4142497 Fatmq1_m total fat pad mass QTL 1 (mouse) Not determined 2 117813147 151813244 Mouse 1301618 Bglu1_m blood glucose level 1 (mouse) Not determined 2 117938185 174308571 Mouse 1300798 Actre3_m activity response to ethanol 3 (mouse) Not determined 2 121125171 155125370 Mouse 1300676 Prdt2_m prion disease incubation time 2 (mouse) Not determined 2 121731402 181608066 Mouse 1301294 Hrtfm5_m heart failure modifier 5 (mouse) Not determined 2 122866831 156866947 Mouse 1301822 Pgia2_m proteoglycan induced arthritis 2 (mouse) Not determined 2 123921127 157921240 Mouse 1357780 Alcrsp2_m alcohol response 2 (mouse) Not determined 2 125515683 159515951 Mouse 1302143 Bwq5_m body weight (mouse) Not determined 2 127647835 161647934 Mouse 1301031 Bdln3_m body length 3 (mouse) Not determined 2 127647835 161647934 Mouse 1558989 Gnf4_m growth and fatness 4 (mouse) Not determined 2 128157520 132697973 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_010554 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01020659 (Get FASTA) Search GEO for Microarray Profiles   AF010237 (Get FASTA) Search GEO for Microarray Profiles   AK156449 (Get FASTA) Search GEO for Microarray Profiles   AL772347 (Get FASTA) Search GEO for Microarray Profiles   AY902318 (Get FASTA) Search GEO for Microarray Profiles   BC003727 (Get FASTA) Search GEO for Microarray Profiles   CH466519 (Get FASTA) Search GEO for Microarray Profiles   M14639 (Get FASTA) Search GEO for Microarray Profiles   X01450 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_010554 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_034684 Peptide Label: precursor Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 129,299,610 - 129,309,972 - ENTREZGENE Mouse cM Map 2   - ENTREZGENE Mouse Celera Assembly 2 130,527,298 - 130,537,642 - RGD Mouse Genome Assembly Build 37 2 129,125,346 - 129,135,708 - RGD Protein Sequences Protein RefSeqs NP_034684 (Get FASTA) GenBank Protein AAA40058 (Get FASTA)   AAC28999 (Get FASTA)   AAH03727 (Get FASTA)   AAX90603 (Get FASTA)   BAE33715 (Get FASTA)   CAA25682 (Get FASTA)   EDL28236 (Get FASTA)   EDL28237 (Get FASTA)   P01582 (Get FASTA) Promoters RGD ID: 6831613 Promoter ID: MM_KWN:31691 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Liver Transcripts: UC008MHR.1 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 2 129,135,576 - 129,136,076 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000027399 ENTREZGENE Ensembl Protein ENSMUSP00000028882 ENTREZGENE Ensembl Transcript ENSMUST00000028882 ENTREZGENE Entrez Gene 16175 ENTREZGENE Germonline ENSMUSG00000027399 HomoloGene Group ID 480 ENTREZGENE InterPro Cytokine_IL1-like UniProtKB/Swiss-Prot   IL1_propep UniProtKB/Swiss-Prot   Interleukin-1_CS UniProtKB/Swiss-Prot   Interleukin_1 UniProtKB/Swiss-Prot   InterleukinIL1A UniProtKB/Swiss-Prot   InterleukinIL1AB UniProtKB/Swiss-Prot IPI IPI00136895 UniProtKB/Swiss-Prot KEGG Report mmu:16175 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:96542 ENTREZGENE PANTHER InterleukinIL1A UniProtKB/Swiss-Prot Pfam IL1 UniProtKB/Swiss-Prot   IL1_propep UniProtKB/Swiss-Prot PRINTS INTERLEUKIN1 UniProtKB/Swiss-Prot   INTRLEUKIN1A UniProtKB/Swiss-Prot   INTRLEUKN1AB UniProtKB/Swiss-Prot PROSITE INTERLEUKIN_1 UniProtKB/Swiss-Prot SMART IL1 UniProtKB/Swiss-Prot Superfamily-SCOP Cytok_IL1_like UniProtKB/Swiss-Prot UniGene Mm.15534 ENTREZGENE UniProt IL1A_MOUSE UniProtKB/Swiss-Prot   Q3U0Y6_MOUSE UniProtKB/TrEMBL   Q62161_MOUSE UniProtKB/TrEMBL

More on Il1a Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 10789 Created: 2000-05-25 Species: Mus musculus Last Modified: 2013-04-23 Status: ACTIVE