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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Liver Reperfusion Injury
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Accession:DOID:9002159 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the liver, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Hepatic Ischemia-Reperfusion Injury;   Hepatic Reperfusion Injury;   Liver Ischemia-Reperfusion Injury


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Liver Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:23762489 RGD:8695935 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ADM adrenomedullin treatment ISO
IDA		 mRNA,protein:increased expression:liver,plasma: RGD PMID:19212187 PMID:19212187 RGD:7364958, RGD:7364958 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO mRNA:increased expression:liver RGD PMID:21431875 RGD:10402078 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member treatment ISO protein:altered expression:liver (mouse)
protein:altered expression:liver (rat)		 RGD PMID:30671488 PMID:29589772 RGD:15036807, RGD:14975297 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ATF6 activating transcription factor 6 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574 		JBrowse link
G ATG13 autophagy related 13 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr11:46,617,553...46,674,518
Ensembl chr11:46,617,527...46,674,818 		JBrowse link
G ATG16L1 autophagy related 16 like 1 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 2:233,251,673...233,295,669
Ensembl chr 2:233,210,051...233,295,674 		JBrowse link
G ATG4D autophagy related 4D cysteine peptidase ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr19:10,543,904...10,553,418
Ensembl chr19:10,543,895...10,553,418 		JBrowse link
G ATG7 autophagy related 7 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO mRNA:increased expression:liver
associated with Non-alcoholic Fatty Liver Disease		 RGD PMID:22647552 PMID:22847887 RGD:10053673, RGD:10053710 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ameliorates
treatment		 ISO mRNA:increased expression:liver
associated with Non-alcoholic Fatty Liver Disease		 RGD PMID:22647552 PMID:34144219 PMID:21092002 PMID:22847887 RGD:10053673, RGD:329812011, RGD:5134995, RGD:10053710 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment
ameliorates		 ISO associated with Non-alcoholic Fatty Liver Disease RGD PMID:22847887 PMID:34144219 PMID:21092002 RGD:10053710, RGD:329812011, RGD:5134995 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 treatment ISO associated with Non-alcoholic Fatty Liver Disease RGD PMID:22847887 RGD:10053710 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BECN1 beclin 1 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G C3 complement C3 treatment ISO RGD PMID:19854450 RGD:11040888 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) treatment ISO RGD PMID:29428101 RGD:13782166 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP3 caspase 3 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:23423194 PMID:15300206 RGD:8661760, RGD:14695087 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 treatment
ameliorates		 ISO RGD PMID:23364428 PMID:34144219 RGD:13782358, RGD:329812011 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ameliorates
treatment
severity		 ISO mRNA, protein:increased expression:liver, serum (rat) RGD PMID:9500701 PMID:34400126 PMID:10630515 PMID:27229110 RGD:8549627, RGD:329902072, RGD:14995929, RGD:14995460 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 treatment
severity		 ISO RGD PMID:28623253 PMID:28623253 RGD:14995305, RGD:14995305 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCL7 C-C motif chemokine ligand 7 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242 		JBrowse link
G CCN1 cellular communication network factor 1 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 severity ISO RGD PMID:27229110 RGD:14995460 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CD14 CD14 molecule ISO RGD PMID:22564590 RGD:7183676 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:14741776 RGD:8547795 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CFH complement factor H treatment ISO
IDA		 mRNA,protein:decreased expression:liver,plasma: RGD PMID:19212187 PMID:19212187 RGD:7364958, RGD:7364958 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
G CS citrate synthase ISO RGD PMID:25416448 RGD:13504849 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G CST3 cystatin C ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ameliorates
treatment		 ISO RGD PMID:21092002 PMID:21092002 PMID:34400126 RGD:5134995, RGD:5134995, RGD:329902072 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 treatment
ameliorates		 ISO RGD PMID:18041715 PMID:34400126 RGD:27095942, RGD:329902072 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA:decreased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G ELANE elastase, neutrophil expressed ISO RGD PMID:10588515 RGD:10450560 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G EPO erythropoietin treatment IDA RGD PMID:25769561 RGD:15090809 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G EPOR erythropoietin receptor ISO protein:increased phosphorylation:liver: RGD PMID:25769561 RGD:15090809 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO RGD PMID:11750579 RGD:11341708 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G FADD Fas associated via death domain treatment ISO RGD PMID:23423194 RGD:8661760 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FAS Fas cell surface death receptor treatment ISO protein:increased expression:liver RGD PMID:17235585 PMID:18561025 PMID:16222447 RGD:2290283, RGD:14700680, RGD:1600351 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand treatment ISO RGD PMID:18561025 RGD:14700680 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FGA fibrinogen alpha chain ISO mRNA:increased expression:liver (rat) RGD PMID:23503399 RGD:9685021 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:12651615 RGD:7205470 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:22564598 PMID:13678701 RGD:329970282, RGD:329970285 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta treatment ISO associated with nonalcoholic fatty liver disease RGD PMID:28807209 RGD:13792730 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO mRNA:decreased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G H2AX H2A.X variant histone treatment ISO RGD PMID:23792534 RGD:8693718 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO mRNA, protein:increased expression, altered localization:serum, hepatocyte, cytoplasm
protein:increased oxidation:liver		 RGD PMID:24578610 PMID:21431875 PMID:22514737 RGD:10402068, RGD:10402078, RGD:10402175 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:20446775 RGD:10755725 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HP haptoglobin treatment ISO RGD PMID:17187421 PMID:21699906 RGD:1626366, RGD:11041815 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO associated with Intestinal Reperfusion Injury;protein:increased expression:liver RGD PMID:7884306 PMID:8780571 RGD:11520784, RGD:14402044 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 severity ISO RGD PMID:28938192 RGD:14985248 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment ISO RGD PMID:22381173 RGD:12791280 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:21911118 RGD:7364839 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:25919765 PMID:14999688 RGD:14696667, RGD:14696668 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL18BP interleukin 18 binding protein ISO mRNA,protein:increased expression:liver RGD PMID:25919765 RGD:14696667 NCBI chr11:71,998,909...72,008,200
Ensembl chr11:71,998,613...72,007,315 		JBrowse link
G IL1A interleukin 1 alpha treatment ISO mRNA:increased expression:lung
protein:increased expression:serum		 RGD PMID:19595018 PMID:9840148 PMID:19283466 RGD:2314952, RGD:11059517, RGD:6907377 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta ameliorates
treatment		 ISO associated with Cholestasis RGD PMID:21468628 PMID:34400126 PMID:32155285 RGD:7175318, RGD:329902072, RGD:155260323 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment IDA
ISO		 rat model treated with human protein RGD PMID:9000676 PMID:12451245 RGD:6909138, RGD:8551710 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL6 interleukin 6 treatment
ameliorates		 ISO RGD PMID:24752458 PMID:34400126 PMID:34144219 PMID:32155285 RGD:11062134, RGD:329902072, RGD:329812011, RGD:155260323 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF8 interferon regulatory factor 8 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,116...85,922,606 		JBrowse link
G ITGAM integrin subunit alpha M treatment
exacerbates		 ISO protein:increased expression:neutrophil (rat) RGD PMID:8387952 PMID:11447039 RGD:329901847, RGD:329901849 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G JAK2 Janus kinase 2 treatment ISO RGD PMID:22288937 RGD:10403073 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365 		JBrowse link
G LBP lipopolysaccharide binding protein ISO mRNA, protein:increased expression:liver RGD PMID:12134092 RGD:9685192 NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ameliorates
exacerbates		 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:30076625 PMID:30622220 RGD:155804280, RGD:155882441 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO protein:increased activity:liver: RGD PMID:11679968 RGD:10412680 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MFN2 mitofusin 2 treatment ISO mRNA, protein:decreased expression:liver (rat) RGD PMID:27363631 PMID:24898700 RGD:12910833, RGD:13204829 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MIR145 microRNA 145 ISO mRNA:decreased expression:small intestine (rat) RGD PMID:23166305 RGD:155230822 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733 		JBrowse link
G MIR155 microRNA 155 ISO RGD PMID:28640790 RGD:21079442 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR21 microRNA 21 ISO RNA:increased expression:liver RGD PMID:29187695 RGD:41410824 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR210 microRNA 210 treatment ISO RGD PMID:32155285 RGD:155260323 NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198 		JBrowse link
G MIR223 microRNA 223 ISO RNA:increased expression:liver
RNA:increased expression:serum,liver		 RGD PMID:19104939 PMID:28646120 RGD:13831297, RGD:21408574 NCBI chr  X:66,018,870...66,018,979
Ensembl chr  X:66,018,870...66,018,979 		JBrowse link
G MIR34A microRNA 34a ISO miRNA:increased expression:liver RGD PMID:28963950 RGD:14695005 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777 		JBrowse link
G MMP15 matrix metallopeptidase 15 ISO mRNA:increased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr16:58,025,754...58,046,901
Ensembl chr16:58,025,754...58,046,901 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO associated with Fatty Liver;mRNA, protein:decreased expression, decreased activity:liver RGD PMID:17255325 RGD:8547976 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO mRNA, protein:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916 		JBrowse link
G MUC17 mucin 17, cell surface associated ISO mRNA, protein:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr 7:101,020,081...101,058,859
Ensembl chr 7:101,020,072...101,058,859 		JBrowse link
G MUC4 mucin 4, cell surface associated ISO mRNA:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr 3:195,746,771...195,811,929
Ensembl chr 3:195,746,765...195,811,973 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 ISO mRNA,protein:increased expression:liver: RGD PMID:36092961 RGD:268357360 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:22288937 PMID:31952110 RGD:10403073, RGD:21201304 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO RGD PMID:28966130 RGD:13450941 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G PF4 platelet factor 4 exacerbates ISO RGD PMID:25440775 RGD:329901829 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment IEP
IDA		 RGD PMID:12605111 PMID:18507760 RGD:11100021, RGD:11100046 NCBI chr 2:127,418,427...127,429,242
Ensembl chr 2:127,418,427...127,429,242 		JBrowse link
G RAB10 RAB10, member RAS oncogene family ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 2:26,033,285...26,137,454
Ensembl chr 2:26,034,084...26,137,454 		JBrowse link
G RAB8B RAB8B, member RAS oncogene family ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr15:63,189,606...63,267,776
Ensembl chr15:63,189,560...63,267,776 		JBrowse link
G SELPLG selectin P ligand ameliorates ISO RGD PMID:16365457 RGD:401717523 NCBI chr12:108,621,895...108,633,894
Ensembl chr12:108,621,895...108,633,894 		JBrowse link
G SERPINC1 serpin family C member 1 treatment ISO
IDA		 RGD PMID:24726586 PMID:8589354 RGD:10450597, RGD:11038771 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,800...173,917,327 		JBrowse link
G SERPINE1 serpin family E member 1 ISO protein:increased activity:plasma (rat) RGD PMID:12353078 RGD:8547901 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPING1 serpin family G member 1 treatment IDA RGD PMID:16367929 RGD:1580273 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171 		JBrowse link
G SIRT1 sirtuin 1 treatment ISO RGD PMID:24557422 RGD:9497542 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor ISO RGD PMID:19595018 RGD:2314952 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564 		JBrowse link
G SOD1 superoxide dismutase 1 treatment IMP human gene in a rat model RGD PMID:16555330 PMID:11779401 RGD:8655889, RGD:1581095 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD3 superoxide dismutase 3 treatment IMP human gene in a rat model RGD PMID:11779401 RGD:1581095 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842 		JBrowse link
G TERT telomerase reverse transcriptase treatment IDA RGD PMID:19545665 RGD:11038676 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068 		JBrowse link
G TFPI tissue factor pathway inhibitor IDA RGD PMID:9921794 RGD:11062061 NCBI chr 2:187,464,230...187,554,435
Ensembl chr 2:187,464,230...187,565,760 		JBrowse link
G TLR2 toll like receptor 2 treatment ISO RGD PMID:16038046 PMID:25769561 RGD:15090805, RGD:15090809 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260 		JBrowse link
G TLR4 toll like receptor 4 treatment
severity		 ISO mRNA:increased expression:liver
protein:increased expression:membrane raft:		 RGD PMID:21431875 PMID:21693218 PMID:22797797 PMID:23395256 PMID:27064547 RGD:10402078, RGD:5685379, RGD:14697702, RGD:14697699, RGD:14697698 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor treatment ISO protein:increased expression:serum (rat) RGD PMID:24726586 PMID:32155285 PMID:11592783 PMID:19357028 PMID:11129814 More... RGD:10450597, RGD:155260323, RGD:2325259, RGD:15039406, RGD:14995473, RGD:14995447, RGD:14985258, RGD:14985257, RGD:14696803 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased localization:mitochondrion RGD PMID:23423194 RGD:8661760 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TRADD TNFRSF1A associated via death domain treatment ISO RGD PMID:23423194 RGD:8661760 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G UCP2 uncoupling protein 2 ISO mRNA:increased expression:liver RGD PMID:22195248 RGD:7175309 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:26451003 RGD:15036791 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G XDH xanthine dehydrogenase treatment ISO RGD PMID:24768926 RGD:13209011 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    Nutritional and Metabolic Diseases 10568
      disease of metabolism 10568
        acquired metabolic disease 3463
          Reperfusion Injury 820
            Liver Reperfusion Injury 109
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      gastrointestinal system disease 8167
        hepatobiliary disease 3236
          liver disease 3104
            Liver Injury 586
              Liver Reperfusion Injury 109
paths to the root