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Gene: CST3 (cystatin C) Homo sapiens
Symbol: CST3
Name: cystatin C
Description: Exhibits several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of catabolic process; and negative regulation of extracellular matrix disassembly. Localizes to Golgi apparatus; extracellular space; and plasma membrane. Implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of the nervous system (multiple); brain ischemia; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARMD11; bA218C14.4 (cystatin C); cystatin 3; cystatin C (amyloid angiopathy and cerebral hemorrhage); cystatin-3; cystatin-C; epididymis secretory protein Li 2; gamma-trace; HEL-S-2; MGC117328; neuroendocrine basic polypeptide; post-gamma-globulin
Mus musculus (house mouse) : Cst3 (cystatin C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cst3 (cystatin C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cst3 (cystatin C)
Pan paniscus (bonobo/pygmy chimpanzee) : CST3 (cystatin C)
Canis lupus familiaris (dog) : LOC607874 (cystatin-C-like)
Sus scrofa (pig) : CST3 (cystatin C)
Chlorocebus sabaeus (African green monkey) : CST3 (cystatin C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2023,626,706 - 23,638,473 (-)EnsemblGRCh38hg38GRCh38
GRCh382023,626,706 - 23,637,955 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372023,608,534 - 23,618,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,562,294 - 23,566,574 (-)NCBINCBI36hg18NCBI36
Build 342023,562,293 - 23,566,574NCBI
Celera2023,687,561 - 23,691,841 (-)NCBI
Cytogenetic Map20p11.21NCBI
HuRef2023,574,763 - 23,578,930 (-)NCBIHuRef
CHM1_12023,608,570 - 23,618,721 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CST3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736914
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.