TLR2 (toll like receptor 2) - Rat Genome Database

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Gene: TLR2 (toll like receptor 2) Homo sapiens
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Symbol: TLR2
Name: toll like receptor 2
RGD ID: 1353654
HGNC Page HGNC:11848
Description: Enables several functions, including lipopolysaccharide binding activity; peptide binding activity; and peptidoglycan binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of defense response. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and response to molecule of bacterial origin. Located in several cellular components, including Golgi apparatus; Toll-like receptor 2-Toll-like receptor 6 protein complex; and membrane raft. Part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); middle ear disease (multiple); and nose disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD282; TIL4; toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC106865.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,684,280 - 153,710,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4153,684,070 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
T2T-CHM13v2.04157,008,777 - 157,030,716 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acne  (IAGP,IEP)
acute kidney failure  (EXP,ISO)
acute necrotizing pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (IAGP,IEP,ISO)
alveolar echinococcosis  (IEP)
anogenital venereal wart  (IEP)
anterior uveitis  (IDA)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aspergillosis  (ISO)
asthma  (IAGP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (IAGP,IDA)
atrial fibrillation  (IEP)
Bacterial Eye Infections  (EXP)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (IAGP,IEP)
Brain Abscess  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (EXP,ISO)
breast cancer  (IAGP)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP)
carotid artery thrombosis  (ISO)
carotid stenosis  (ISO)
cholangitis  (ISO)
cholestasis  (EXP)
cholesteatoma  (IEP)
cholesteatoma of middle ear  (IEP)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (IEP)
Chronic Pain  (IDA)
Chronic Periodontitis  (IEP)
clonorchiasis  (ISO)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
congestive heart failure  (EXP)
Cough  (IEP)
cutaneous leishmaniasis  (IEP)
cystic echinococcosis  (IAGP,IEP)
dermatomyositis  (IEP)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (IAGP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
dry eye syndrome  (IEP,ISO)
Dyslipidemias  (ISO)
end stage renal disease  (IEP)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (EXP)
Escherichia Coli Meningitis  (ISO)
essential hypertension  (EXP)
eumycotic mycetoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (IEP)
Fever  (ISO)
Fungal Eye Infections  (ISO)
gastroesophageal reflux disease  (IEP)
glomerulonephritis  (ISO)
Gram-Positive Bacterial Infections  (ISO)
Hearing Loss  (IAGP)
hepatitis B  (ISO)
hepatocellular carcinoma  (IAGP,ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (IEP)
Hyperalgesia  (ISO)
ileitis  (ISO)
Inflammation  (EXP,ISO)
invasive aspergillosis  (ISO)
keratitis  (EXP,IEP,ISO)
keratoconjunctivitis  (IEP)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (IEP)
leprosy  (EXP,IAGP)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IAGP,ISO)
mastoiditis  (IEP)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (IAGP)
mite infestation  (EXP)
molluscum contagiosum  (IEP)
myelodysplastic syndrome  (EXP)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (IEP)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
Oral Lichen Planus  (IEP)
otitis media  (IEP,ISO)
Otitis Media with Effusion  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Plaque, Atherosclerotic  (IEP)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
prostate cancer  (IAGP)
Pseudomonas Aeruginosa Keratitis  (IEP)
psoriasis  (IEP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (IEP,ISO)
pulmonary tuberculosis  (IAGP,IEP)
renal fibrosis  (ISO)
Reperfusion Injury  (EXP,ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (EXP)
rhinitis  (IAGP,IEP)
Rhinosinusitis  (IAGP,IEP)
sciatic neuropathy  (ISO)
seborrheic dermatitis  (IDA)
Sepsis  (ISO)
severe acute respiratory syndrome  (IEP)
sinusitis  (IEP)
skin papilloma  (IEP)
Staphylococcal Infections  (EXP)
Streptococcal Infections  (ISO)
suppurative otitis media  (IEP)
Transplant Rejection  (IAGP,IEP,ISO)
tuberculosis  (EXP,IAGP)
type 1 diabetes mellitus  (IAGP,IEP,ISO)
typhoid fever  (ISO)
urinary bladder cancer  (IAGP)
urinary tract infection  (IAGP)
visceral leishmaniasis  (ISO)
vitiligo  (IAGP)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-mercaptopropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
acetamide  (ISO)
adapalene  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (EXP)
alfacalcidol  (EXP)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
alpha-D-galactose  (ISO)
ammonium hexachloroplatinate  (EXP)
amphetamine  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
astaxanthin  (ISO)
astemizole  (ISO)
atorvastatin calcium  (EXP)
azathioprine  (EXP,ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (EXP)
butanal  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon atom  (EXP)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
cerium trichloride  (ISO)
CGP 52608  (EXP)
chitosan  (EXP)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cyproconazole  (ISO)
D-glucose  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
fenoldopam  (ISO)
ferric oxide  (ISO)
ferulic acid  (ISO)
fipronil  (ISO)
folic acid  (ISO)
fonofos  (EXP)
furan  (ISO)
galactose  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP)
glutathione  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphene oxide  (ISO)
hexamethylene diisocyanate  (EXP)
histamine  (EXP)
hyaluronic acid  (ISO)
hydroxycitronellal  (EXP)
icosanoid  (ISO)
indometacin  (EXP,ISO)
indoprofen  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoeugenol  (EXP)
ivermectin  (EXP)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levamisole  (ISO)
lipophosphoglycan  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lycopene  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methylseleninic acid  (EXP)
muramyl dipeptide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nitrites  (ISO)
nitroprusside  (ISO)
o-anisidine  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
peptidoglycan  (EXP,ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(I:C)  (EXP)
prednisolone  (EXP)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
prostaglandin E2  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium aurothiomalate  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sulfasalazine  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
tacrolimus hydrate  (ISO)
terbufos  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trans-isoeugenol  (EXP)
tributyrin  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
Tungsten carbide  (EXP)
vinclozolin  (ISO)
vitamin D  (EXP,ISO)
vorinostat  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (TAS)
cell activation  (IDA)
cell surface pattern recognition receptor signaling pathway  (ISO)
cellular response to bacterial lipopeptide  (ISO,TAS)
cellular response to diacyl bacterial lipopeptide  (IDA)
cellular response to lipoteichoic acid  (IDA,IMP)
cellular response to peptidoglycan  (ISO)
cellular response to triacyl bacterial lipopeptide  (IDA)
cellular response to type II interferon  (IDA)
central nervous system myelin formation  (IEA,ISO)
defense response  (ISO)
defense response to Gram-positive bacterium  (IDA,ISO)
defense response to virus  (IEP)
detection of diacyl bacterial lipopeptide  (IDA)
detection of triacyl bacterial lipopeptide  (IDA)
ERK1 and ERK2 cascade  (ISO)
I-kappaB phosphorylation  (IDA)
immune response  (IEA,TAS)
immune system process  (IEA)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IEA,NAS,TAS)
learning  (ISS)
leukocyte migration  (ISO)
leukotriene metabolic process  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA)
microglia development  (ISS)
microglial cell activation  (IEA,ISO)
MyD88-dependent toll-like receptor signaling pathway  (IEA,ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of phagocytosis  (ISS)
negative regulation of synapse assembly  (ISS)
neutrophil migration  (ISO)
NIK/NF-kappaB signaling  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide metabolic process  (IEA,ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (IDA)
positive regulation of chemokine production  (IDA,ISO)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (IC,IGI)
positive regulation of interferon-beta production  (ISS)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (ISS)
positive regulation of interleukin-18 production  (ISS)
positive regulation of interleukin-6 production  (IDA,IGI,ISO)
positive regulation of interleukin-8 production  (IDA,IGI)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of matrix metallopeptidase secretion  (IGI)
positive regulation of neutrophil migration  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of NIK/NF-kappaB signaling  (IDA,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISS)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
positive regulation of toll-like receptor signaling pathway  (IDA)
positive regulation of transcription by RNA polymerase II  (ISS)
positive regulation of tumor necrosis factor production  (ISO,ISS)
positive regulation of Wnt signaling pathway  (IMP)
positive regulation of xenophagy  (ISO)
regulation of cytokine production  (IEA)
regulation of dendritic cell cytokine production  (ISO)
response to bacterial lipoprotein  (IEA,ISO)
response to bacterium  (ISO)
response to fatty acid  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to insulin  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to molecule of bacterial origin  (IEA)
response to molecule of fungal origin  (ISO)
response to peptidoglycan  (ISO)
response to progesterone  (IEA,ISO)
response to toxic substance  (IEA,ISO)
signal transduction  (IEA,TAS)
toll-like receptor 2 signaling pathway  (IEA)
toll-like receptor signaling pathway  (IBA,IDA,IEA,ISO,ISS)
toll-like receptor TLR6:TLR2 signaling pathway  (IDA)
xenophagy  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Changes of Toll-like Receptor mRNA and Related Cytokines in Patients with Hepatic Alveolar Echinococcosis]. Abudusalamu A, etal., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2016 Dec;34(6):542-6.
2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Amura CR, etal., Mol Immunol. 2012 Oct;52(3-4):249-57. doi: 10.1016/j.molimm.2012.05.020. Epub 2012 Jun 27.
4. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
5. Immunolocalization of toll-like receptor 2 in viral warts and molluscum contagiosum. Bakry OA, etal., Anal Quant Cytol Histol. 2013 Dec;35(6):316-23.
6. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Balloy V, etal., Infect Immun. 2005 Sep;73(9):5420-5.
7. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
8. Toll-like-receptor gene polymorphisms in a Tunisian population with Behcet's disease. Ben Dhifallah I, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S58-62.
9. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
10. A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma. Bjornvold M, etal., Genes Immun. 2009 Mar;10(2):181-7. Epub 2009 Jan 15.
11. Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. Bochud PY, etal., J Infect Dis. 2008 Jan 15;197(2):253-61. doi: 10.1086/524688.
12. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76.
13. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
14. MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131.
15. A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators. Broen JC, etal., Arthritis Rheum. 2012 Jan;64(1):264-71. doi: 10.1002/art.33325.
16. TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31.
17. R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins. Brown RA, etal., Transplantation. 2010 Apr 15;89(7):811-5. doi: 10.1097/TP.0b013e3181cbac18.
18. Toll like receptor-2 modulates both innate and adaptive immune responses during chronic fungal asthma in mice. Buckland KF, etal., Inflamm Res. 2008 Aug;57(8):379-87.
19. Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. Caricilli AM, etal., J Endocrinol. 2008 Dec;199(3):399-406. Epub 2008 Sep 11.
20. TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24.
21. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Chang JH, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1711-7.
22. TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.
23. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74.
24. Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. Chen X, etal., J Infect Dis. 2009 Aug 1;200(3):399-408.
25. Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts. Chen YC, etal., BMC Med Genet. 2010 Jan 30;11:17.
26. Staphylococcus aureus accelerates an experimental allergic conjunctivitis by Toll-like receptor 2-dependent manner. Chung SH, etal., Clin Immunol. 2009 Apr;131(1):170-7.
27. Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators. Claeys S, etal., Clin Exp Allergy. 2005 Apr;35(4):467-72.
28. Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Cook EB, etal., Ann Allergy Asthma Immunol. 2005 Apr;94(4):486-97.
29. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14.
30. HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2. De Re V, etal., Oncotarget. 2016 Jun 21;7(25):37487-37497. doi: 10.18632/oncotarget.9303.
31. Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. Dessing MC, etal., PLoS One. 2009 Nov 24;4(11):e7993.
32. Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy. Devaraj S, etal., Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1796-804. doi: 10.1161/ATVBAHA.111.228924. Epub 2011 May 26.
33. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20.
34. Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM. Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17.
35. Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis. Ekman AK, etal., Int Arch Allergy Immunol. 2012;159(1):6-14. doi: 10.1159/000335196. Epub 2012 Apr 27.
36. Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population. Fang J, etal., Invest Ophthalmol Vis Sci. 2013 Dec 30;54(13):8384-92. doi: 10.1167/iovs.13-12878.
37. Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury. Farrar CA, etal., FASEB J. 2012 Feb;26(2):799-807. doi: 10.1096/fj.11-195396. Epub 2011 Oct 31.
38. Expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. Fathy A, etal., Egypt J Immunol. 2009;16(1):127-34.
39. Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells. Forte A, etal., Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8.
40. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
41. Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5.
42. A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. Fuchs B, etal., Int Arch Allergy Immunol. 2010;152(2):131-9. Epub 2009 Dec 16.
43. Choroidal neovascularization enhanced by Chlamydia pneumoniae via Toll-like receptor 2 in the retinal pigment epithelium. Fujimoto T, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4694-702. doi: 10.1167/iovs.09-4464. Epub 2010 Apr 14.
44. Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis. Gabrilovich MI, etal., Clin Exp Immunol. 2013 Sep;173(3):512-22. doi: 10.1111/cei.12138.
45. GSK-3beta inhibitor modulates TLR2/NF-kappaB signaling following myocardial ischemia-reperfusion. Gao HK, etal., Inflamm Res. 2009 Mar 10.
46. Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. Garcia-Rodriguez S, etal., J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50.
47. Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis. Gillette-Ferguson I, etal., Infect Immun. 2007 Dec;75(12):5908-15. Epub 2007 Sep 17.
48. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
49. Toll-like receptor 2 siRNA suppresses corneal inflammation and attenuates Aspergillus fumigatus keratitis in rats. Guo H, etal., Immunol Cell Biol. 2012 Mar;90(3):352-7. doi: 10.1038/icb.2011.49. Epub 2011 Jun 7.
50. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
51. Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. Hajishengallis G, etal., J Immunol. 2008 Sep 15;181(6):4141-9.
52. Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media. Han F, etal., Infect Immun. 2009 Jul;77(7):3100-8. doi: 10.1128/IAI.00204-09. Epub 2009 May 4.
53. Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. Hasannejad H, etal., J Allergy Clin Immunol. 2007 Jul;120(1):69-75. Epub 2007 May 25.
54. Toll-like receptor 2-mediated NF-kappaB inflammatory responses in dry eye associated with cGVHD. He C, etal., Mol Vis. 2011;17:2605-11. Epub 2011 Oct 5.
55. Tlr2 is critical for diet-induced metabolic syndrome in a murine model. Himes RW and Smith CW, FASEB J. 2010 Mar;24(3):731-9. doi: 10.1096/fj.09-141929. Epub 2009 Oct 19.
56. Expression of toll-like receptors in chronic otitis media and cholesteatoma. Hirai H, etal., Int J Pediatr Otorhinolaryngol. 2013 May;77(5):674-6. doi: 10.1016/j.ijporl.2013.01.010. Epub 2013 Feb 4.
57. Impact of Toll-like receptor 2 expression in renal allograft rejection. Hoffmann U, etal., Nephrol Dial Transplant. 2011 Mar;26(3):1080-7. doi: 10.1093/ndt/gfq420. Epub 2010 Jul 13.
58. Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy. Huang Z, etal., Antiviral Res. 2015 Jun;118:10-9. doi: 10.1016/j.antiviral.2015.03.004. Epub 2015 Mar 12.
59. Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. Hubschle T, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R180-7. Epub 2005 Sep 8.
60. Toll-like receptor 2 is highly expressed in lesions of acne inversa and colocalizes with C-type lectin receptor. Hunger RE, etal., Br J Dermatol. 2008 Apr;158(4):691-7. doi: 10.1111/j.1365-2133.2007.08425.x. Epub 2008 Jan 30.
61. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis. Hussein YM, etal., Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
62. The role of infection in the development of non-valvular atrial fibrillation: up-regulation of Toll-like receptor 2 expression levels on monocytes. Ichiki H, etal., J Cardiol. 2009 Feb;53(1):127-35. doi: 10.1016/j.jjcc.2008.09.008. Epub 2008 Nov 25.
63. Double blind clinical trial in a series of 115 patients with seborrheic dermatitis: prevention of relapses using a topical modulator of Toll like receptor 2. Ionescu MA, etal., G Ital Dermatol Venereol. 2011 Jun;146(3):185-9.
64. Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study. Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
65. Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways. Ji L, etal., FEBS Lett. 2014 Jun 5;588(12):2095-100. doi: 10.1016/j.febslet.2014.04.042. Epub 2014 May 8.
66. Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis. Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
67. Expression of toll-like receptors in the Fusarium solani infected cornea. Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
68. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
69. [Effects of intestinal trefoil factor on Toll-like receptors 2 and 4 expression in intestinal tissue in young rats with endotoxemia]. Jing K and Sun M, Zhongguo Dang Dai Er Ke Za Zhi. 2011 Dec;13(12):985-8.
70. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Jäckel S, etal., Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.
71. Toll-like receptor 2 expression level on monocytes in patients with viral infections: monitoring infection severity. Kajiya T, etal., J Infect. 2008 Sep;57(3):249-59. Epub 2008 Jul 26.
72. Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
73. TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients. Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
74. Beneficial effects of TLR-2/6 ligation in pulmonary bacterial infection and immunization with Pseudomonas aeruginosa. Kerber-Momot T, etal., Inflammation. 2010 Feb;33(1):58-64.
75. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
76. Delayed administration of pituitary adenylate cyclase-activating polypeptide 38 ameliorates renal ischemia/reperfusion injury in mice by modulating Toll-like receptors. Khan AM, etal., Peptides. 2012 Dec;38(2):395-403. doi: 10.1016/j.peptides.2012.09.023. Epub 2012 Sep 28.
77. Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Kielian T, etal., Infect Immun. 2005 Nov;73(11):7428-35.
78. Ischemia-reperfusion injury activates innate immunity in rat kidneys. Kim BS, etal., Transplantation. 2005 May 27;79(10):1370-7.
79. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. Kim D, etal., J Biol Chem. 2007 May 18;282(20):14975-83. Epub 2007 Mar 13.
80. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
81. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Kim HS, etal., Immunity. 2007 Aug;27(2):321-33. Epub 2007 Aug 16.
82. Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever. Knorr C, etal., Brain Res. 2008 Apr 18;1205:36-46. Epub 2008 Feb 21.
83. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
84. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
85. Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis. Kumar A, etal., J Infect Dis. 2010 Jan 15;201(2):255-63. doi: 10.1086/649589.
86. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
87. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Kurt-Jones EA, etal., Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1315-20. Epub 2004 Jan 22.
88. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
89. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. Leemans JC, etal., PLoS One. 2009 May 27;4(5):e5704. doi: 10.1371/journal.pone.0005704.
90. TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. Leendertse M, etal., J Immunol. 2008 Apr 1;180(7):4865-74.
91. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Leichtle A, etal., Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.
92. [Potential role of JAK/STAT in regulating Toll-like receptor 2 gene expression in rats with postburn Staphylococcus aureus sepsis] Li HY, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2003 Mar;15(3):139-42.
93. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
94. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways. Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
95. Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9.
96. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice. Lin H, etal., Hepatology. 2013 Jan;57(1):171-82. doi: 10.1002/hep.25991.
97. Pre-Activation of Toll-Like Receptor 2 Enhances CD8+ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models. Lin Y, etal., Front Immunol. 2018 Jun 29;9:1495. doi: 10.3389/fimmu.2018.01495. eCollection 2018.
98. MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice. Lin YC, etal., Biochem Biophys Res Commun. 2018 Feb 12;496(3):880-886. doi: 10.1016/j.bbrc.2018.01.132. Epub 2018 Jan 31.
99. Erythropoietin pretreatment exerts anti-inflammatory effects in hepatic ischemia/reperfusion-injured rats via suppression of the TLR2/NF-κB pathway. Liu QS, etal., Transplant Proc. 2015 Mar;47(2):283-9. doi: 10.1016/j.transproceed.2014.10.045.
100. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Liu X, etal., Atherosclerosis. 2008 Jan;196(1):146-54. Epub 2007 Apr 26.
101. Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. Liu X, etal., Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):6012-7. doi: 10.1167/iovs.13-12159.
102. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
103. Relationship between expression of toll-like receptors 2/4 in dendritic cells and chronic hepatitis B virus infection. Lu X, etal., Int J Clin Exp Pathol. 2014 Aug 15;7(9):6048-55. eCollection 2014.
104. [Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats] Lu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):138-41.
105. Gut microbiota translocation promotes autoimmune cholangitis. Ma HD, etal., J Autoimmun. 2018 Dec;95:47-57. doi: 10.1016/j.jaut.2018.09.010. Epub 2018 Oct 17.
106. Association of Toll-like receptor (TLR) 2, 3 and 9 genes polymorphism with prostate cancer risk in North Indian population. Mandal RK, etal., Mol Biol Rep. 2012 Jul;39(7):7263-9. doi: 10.1007/s11033-012-1556-5. Epub 2012 Feb 6.
107. In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
108. Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study. Mohamed IN, etal., Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.
109. A clinical association between Toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: A case control study. Moradkhani MA, etal., Comp Immunol Microbiol Infect Dis. 2019 Oct;66:101336. doi: 10.1016/j.cimid.2019.101336. Epub 2019 Jul 24.
110. Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain. Mottahedin A, etal., J Cereb Blood Flow Metab. 2017 Apr;37(4):1192-1198. doi: 10.1177/0271678X17691292. Epub 2017 Jan 1.
111. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
112. Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver. Murray HW, etal., Infect Immun. 2013 Jul;81(7):2318-26. doi: 10.1128/IAI.01468-12. Epub 2013 Apr 15.
113. Involvement of innate immunity in the pathogenesis of intestinal Behcet's disease. Nara K, etal., Clin Exp Immunol. 2008 May;152(2):245-51. doi: 10.1111/j.1365-2249.2008.03626.x. Epub 2008 Mar 10.
114. The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C. Nischalke HD, etal., Int J Cancer. 2012 Mar 15;130(6):1470-5. doi: 10.1002/ijc.26143. Epub 2011 Jun 18.
115. Role of Toll-like receptor (TLR) 2 in experimental Bacillus cereus endophthalmitis. Novosad BD, etal., PLoS One. 2011;6(12):e28619. doi: 10.1371/journal.pone.0028619. Epub 2011 Dec 6.
116. Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis. Oh DY, etal., Allergy. 2009 Nov;64(11):1608-15. doi: 10.1111/j.1398-9995.2009.02066.x. Epub 2009 Jul 21.
117. Enhanced expression of Toll-like receptor 2 in lesional tissues and peripheral blood monocytes of patients with oral lichen planus. Ohno S, etal., J Dermatol. 2011 Apr;38(4):335-44.
118. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
119. Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis. Park CS, etal., Otolaryngol Head Neck Surg. 2011 Jan;144(1):96-100. doi: 10.1177/0194599810390881.
120. Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility. Park Y, etal., Ann N Y Acad Sci. 2004 Dec;1037:170-4.
121. Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Paul-Clark MJ, etal., Am J Respir Crit Care Med. 2009 Feb 15;179(4):299-306. Epub 2008 Nov 14.
122. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
123. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
124. Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease. Puliti M, etal., Infect Immun. 2009 Apr;77(4):1524-31. doi: 10.1128/IAI.00965-08. Epub 2009 Jan 29.
125. Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. Qian FH, etal., J Investig Allergol Clin Immunol. 2010;20(4):340-6.
126. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
127. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
128. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
129. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
130. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
131. Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.
132. TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a multicenter study. Salpietro C, etal., Int J Immunopathol Pharmacol. 2011 Oct;24(4 Suppl):33-40.
133. No association of TLR2 and TLR4 polymorphisms with type I diabetes mellitus in the Basque population. Santin I, etal., Ann N Y Acad Sci. 2006 Oct;1079:268-72.
134. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
135. Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
136. TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
137. The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response. Shi XQ, etal., Glia. 2011 Feb;59(2):231-41. doi: 10.1002/glia.21093.
138. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
139. [Differential expression of toll-like receptors in chronic suppurative otitis media and cholesteatoma]. Si Y, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):388-93.
140. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
141. Single-nucleotide Polymorphisms in Genes Encoding Toll-like Receptor -2, -3, -4, and -9 in a Case-Control Study with Bladder Cancer Susceptibility in a North Indian Population. Singh V, etal., Arch Med Res. 2013 Jan;44(1):54-61. doi: 10.1016/j.arcmed.2012.10.008. Epub 2012 Nov 6.
142. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Smit LA, etal., Am J Respir Crit Care Med. 2009 Mar 1;179(5):363-8. Epub 2008 Dec 18.
143. Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis. Summers SA, etal., Arthritis Rheum. 2011 Apr;63(4):1124-35. doi: 10.1002/art.30208.
144. Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
145. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Sun Y, etal., Infect Immun. 2006 Sep;74(9):5325-32.
146. Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. Tabel Y, etal., Int J Immunogenet. 2007 Dec;34(6):399-405.
147. [Methylprednisolone enhances the expression of Toll-like receptor 2 on macrophages in induced sputum from patients with chronic cough]. Tang CW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Feb;34(2):123-7.
148. Assessment of Toll-like receptor 2 gene polymorphisms in severe chronic rhinosinusitis. Tewfik MA, etal., J Otolaryngol Head Neck Surg. 2008 Aug;37(4):552-8.
149. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Theodoropoulos GE, etal., Breast. 2012 Aug;21(4):534-8. doi: 10.1016/j.breast.2012.04.001. Epub 2012 May 2.
150. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Tian LM, etal., Dermatology. 2010;221(3):276-84. doi: 10.1159/000319851.
151. Enhanced immediate inflammatory response to Streptococcus pneumoniae in the lungs of mice with pulmonary emphysema. Tokairin Y, etal., Respirology. 2008 May;13(3):324-32.
152. Involvement of toll-like receptor 2 and 4 in association between dyslipidemia and osteoclast differentiation in apolipoprotein E deficient rat periodontium. Tomofuji T, etal., Lipids Health Dis. 2013 Jan 8;12(1):1.
153. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Tu CT, etal., Food Chem Toxicol. 2012 Sep;50(9):3343-51. doi: 10.1016/j.fct.2012.05.050. Epub 2012 Jun 7.
154. Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. Tullos NA, etal., Curr Eye Res. 2013 Oct;38(10):1036-48. doi: 10.3109/02713683.2013.804094. Epub 2013 Jul 10.
155. The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. Tuon FF, etal., J Dermatol Sci. 2010 Jul;59(1):55-7. doi: 10.1016/j.jdermsci.2010.04.009. Epub 2010 May 20.
156. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. van Well GT, etal., PLoS One. 2012;7(5):e35837. doi: 10.1371/journal.pone.0035837. Epub 2012 May 25.
157. Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
158. Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. Vanhinsbergh LJ, etal., Ann Allergy Asthma Immunol. 2007 Dec;99(6):509-16. doi: 10.1016/S1081-1206(10)60379-1.
159. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Velez DR, etal., Int J Tuberc Lung Dis. 2009 Sep;13(9):1068-76.
160. [Expression of toll-like receptor mRNA in epithelial cell of nasal mucosa]. Wang CS and Dong Z, Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):243-6.
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PMID:23534406   PMID:23555011   PMID:23565226   PMID:23578092   PMID:23589304   PMID:23593431   PMID:23599654   PMID:23606791   PMID:23614732   PMID:23616573   PMID:23619473   PMID:23626692  
PMID:23629653   PMID:23638011   PMID:23643268   PMID:23644137   PMID:23657466   PMID:23663325   PMID:23671673   PMID:23680675   PMID:23684765   PMID:23722608   PMID:23747679   PMID:23765228  
PMID:23786414   PMID:23787127   PMID:23796347   PMID:23817958   PMID:23819907   PMID:23821954   PMID:23826189   PMID:23830055   PMID:23855294   PMID:23861881   PMID:23864765   PMID:23866094  
PMID:23875738   PMID:23906542   PMID:23940075   PMID:23968377   PMID:23980810   PMID:23985798   PMID:23992203   PMID:23998736   PMID:24011352   PMID:24043886   PMID:24051092   PMID:24068346  
PMID:24074256   PMID:24080302   PMID:24112285   PMID:24116867   PMID:24120511   PMID:24124467   PMID:24143215   PMID:24144680   PMID:24240055   PMID:24242044   PMID:24265267   PMID:24277938  
PMID:24286242   PMID:24294367   PMID:24325722   PMID:24340055   PMID:24346141   PMID:24352680   PMID:24361386   PMID:24366499   PMID:24371373   PMID:24376595   PMID:24387801   PMID:24391778  
PMID:24412244   PMID:24440818   PMID:24466313   PMID:24493819   PMID:24508688   PMID:24511099   PMID:24512642   PMID:24524679   PMID:24533976   PMID:24558109   PMID:24558401   PMID:24578102  
PMID:24586537   PMID:24594065   PMID:24612386   PMID:24626284   PMID:24658140   PMID:24661005   PMID:24670381   PMID:24727508   PMID:24733511   PMID:24752463   PMID:24760207   PMID:24771848  
PMID:24773611   PMID:24790027   PMID:24795054   PMID:24801457   PMID:24813591   PMID:24863068   PMID:24872416   PMID:24882191   PMID:24882571   PMID:24902362   PMID:24912772   PMID:24918749  
PMID:24922103   PMID:24922578   PMID:24927726   PMID:24929142   PMID:24964964   PMID:24975964   PMID:24999538   PMID:25001940   PMID:25023285   PMID:25042766   PMID:25047402   PMID:25057020  
PMID:25068657   PMID:25115098   PMID:25121610   PMID:25123610   PMID:25152369   PMID:25172490   PMID:25179298   PMID:25180535   PMID:25180613   PMID:25200491   PMID:25208763   PMID:25214272  
PMID:25244363   PMID:25265071   PMID:25265998   PMID:25270212   PMID:25318894   PMID:25373689   PMID:25375272   PMID:25402006   PMID:25403387   PMID:25405275   PMID:25406630   PMID:25408375  
PMID:25427560   PMID:25431887   PMID:25465639   PMID:25466255   PMID:25466615   PMID:25467401   PMID:25482673   PMID:25487598   PMID:25530138   PMID:25531754   PMID:25541252   PMID:25542811  
PMID:25549591   PMID:25549945   PMID:25553878   PMID:25563498   PMID:25589072   PMID:25603825   PMID:25604476   PMID:25605403   PMID:25622945   PMID:25624047   PMID:25639337   PMID:25660311  
PMID:25675790   PMID:25679217   PMID:25689620   PMID:25706930   PMID:25716539   PMID:25765738   PMID:25784560   PMID:25790282   PMID:25796310   PMID:25846753   PMID:25862837   PMID:25870276  
PMID:25872171   PMID:25877355   PMID:25893499   PMID:25920454   PMID:25934696   PMID:25935862   PMID:25954926   PMID:25955717   PMID:25959254   PMID:25969543   PMID:25973005   PMID:26022377  
PMID:26023918   PMID:26055429   PMID:26055925   PMID:26071220   PMID:26079624   PMID:26082489   PMID:26132135   PMID:26167073   PMID:26177128   PMID:26188904   PMID:26191227   PMID:26208141  
PMID:26220088   PMID:26226614   PMID:26238371   PMID:26253933   PMID:26272943   PMID:26297794   PMID:26309029   PMID:26310831   PMID:26320741   PMID:26345801   PMID:26347747   PMID:26367274  
PMID:26386242   PMID:26388234   PMID:26398587   PMID:26426362   PMID:26440284   PMID:26476743   PMID:26490558   PMID:26497845   PMID:26498675   PMID:26548749   PMID:26563875   PMID:26568059  
PMID:26569074   PMID:26590148   PMID:26592460   PMID:26616674   PMID:26617949   PMID:26621243   PMID:26624894   PMID:26635448   PMID:26643105   PMID:26649771   PMID:26668319   PMID:26682905  
PMID:26689559   PMID:26695672   PMID:26695933   PMID:26709456   PMID:26722451   PMID:26738351   PMID:26759164   PMID:26778002   PMID:26785369   PMID:26794428   PMID:26841679   PMID:26866668  
PMID:26871637   PMID:26880585   PMID:26908090   PMID:26930710   PMID:26950997   PMID:26963509   PMID:26982743   PMID:26988751   PMID:26999096   PMID:27002100   PMID:27004566   PMID:27016001  
PMID:27029120   PMID:27077833   PMID:27079437   PMID:27084682   PMID:27090786   PMID:27095543   PMID:27108590   PMID:27124026   PMID:27142735   PMID:27150852   PMID:27151672   PMID:27155792  
PMID:27173229   PMID:27179140   PMID:27185658   PMID:27221282   PMID:27223696   PMID:27252945   PMID:27253707   PMID:27260411   PMID:27273576   PMID:27274225   PMID:27302665   PMID:27323068  
PMID:27326654   PMID:27364547   PMID:27365531   PMID:27371850   PMID:27373686   PMID:27375111   PMID:27380627   PMID:27381289   PMID:27470911   PMID:27492456   PMID:27495363   PMID:27503209  
PMID:27507606   PMID:27515449   PMID:27563808   PMID:27567430   PMID:27590684   PMID:27616304   PMID:27652268   PMID:27689189   PMID:27695100   PMID:27708357   PMID:27723526   PMID:27727278  
PMID:27755461   PMID:27783847   PMID:27793087   PMID:27793374   PMID:27805901   PMID:27849015   PMID:27882497   PMID:27888296   PMID:27902761   PMID:27909057   PMID:27909766   PMID:27917620  
PMID:27928019   PMID:27941651   PMID:27943385   PMID:27996041   PMID:28009434   PMID:28024924   PMID:28033388   PMID:28061318   PMID:28061462   PMID:28078022   PMID:28083607   PMID:28087373  
PMID:28088611   PMID:28118851   PMID:28122717   PMID:28202935   PMID:28220810   PMID:28255201   PMID:28256509   PMID:28296959   PMID:28327786   PMID:28329297   PMID:28332241   PMID:28341816  
PMID:28369600   PMID:28388655   PMID:28403045   PMID:28411360   PMID:28418842   PMID:28443596   PMID:28445304   PMID:28481875   PMID:28487240   PMID:28494727   PMID:28497211   PMID:28500897  
PMID:28502147   PMID:28514297   PMID:28514442   PMID:28518213   PMID:28536605   PMID:28560381   PMID:28622534   PMID:28624699   PMID:28665005   PMID:28667380   PMID:28703296   PMID:28729076  
PMID:28730622   PMID:28734965   PMID:28736863   PMID:28739342   PMID:28775078   PMID:28800779   PMID:28802400   PMID:28815701   PMID:28827637   PMID:28834234   PMID:28841215   PMID:28844021  
PMID:28844484   PMID:28858111   PMID:28887059   PMID:28911197   PMID:28986953   PMID:29021606   PMID:29030987   PMID:29066233   PMID:29084899   PMID:29085211   PMID:29112296   PMID:29160122  
PMID:29183333   PMID:29196459   PMID:29208238   PMID:29269299   PMID:29286178   PMID:29320990   PMID:29323102   PMID:29324261   PMID:29375116   PMID:29452169   PMID:29457581   PMID:29474374  
PMID:29486365   PMID:29543867   PMID:29553590   PMID:29566186   PMID:29634390   PMID:29658577   PMID:29672867   PMID:29675696   PMID:29686176   PMID:29689497   PMID:29695002   PMID:29712918  
PMID:29727015   PMID:29755012   PMID:29778672   PMID:29813046   PMID:29844243   PMID:29883450   PMID:29909409   PMID:29923769   PMID:29924447   PMID:29959987   PMID:29968427   PMID:29990310  
PMID:30028533   PMID:30029898   PMID:30043528   PMID:30049532   PMID:30070088   PMID:30111593   PMID:30118246   PMID:30134807   PMID:30196472   PMID:30215163   PMID:30218032   PMID:30230051  
PMID:30246618   PMID:30261531   PMID:30273064   PMID:30301709   PMID:30337494   PMID:30357962   PMID:30364936   PMID:30459192   PMID:30536754   PMID:30550567   PMID:30554285   PMID:30578304  
PMID:30596396   PMID:30618413   PMID:30631444   PMID:30647133   PMID:30684639   PMID:30702075   PMID:30728747   PMID:30733958   PMID:30806798   PMID:30808918   PMID:30853520   PMID:30888638  
PMID:30898699   PMID:30908604   PMID:30908938   PMID:30924423   PMID:30993517   PMID:31010815   PMID:31017904   PMID:31028612   PMID:31082340   PMID:31084431   PMID:31086276   PMID:31114588  
PMID:31125591   PMID:31132191   PMID:31153046   PMID:31154053   PMID:31162913   PMID:31183403   PMID:31221720   PMID:31304782   PMID:31336481   PMID:31347700   PMID:31379806   PMID:31383741  
PMID:31403268   PMID:31451010   PMID:31465768   PMID:31494992   PMID:31495224   PMID:31558608   PMID:31570693   PMID:31578573   PMID:31578587   PMID:31615295   PMID:31644579   PMID:31655342  
PMID:31656159   PMID:31658592   PMID:31662521   PMID:31667864   PMID:31678868   PMID:31710083   PMID:31734268   PMID:31734843   PMID:31781672   PMID:31843260   PMID:31930972   PMID:31936430  
PMID:31980649   PMID:31990466   PMID:31999637   PMID:32043507   PMID:32057259   PMID:32066304   PMID:32075760   PMID:32124394   PMID:32124747   PMID:32146682   PMID:32173651   PMID:32222425  
PMID:32224213   PMID:32233518   PMID:32240801   PMID:32281447   PMID:32284335   PMID:32349717   PMID:32424768   PMID:32426871   PMID:32449979   PMID:32461342   PMID:32470550   PMID:32486097  
PMID:32516401   PMID:32529494   PMID:32545403   PMID:32554157   PMID:32576819   PMID:32576967   PMID:32606656   PMID:32618365   PMID:32634389   PMID:32648572   PMID:32703481   PMID:32751735  
PMID:32799786   PMID:32827217   PMID:32831974   PMID:32842834   PMID:32867455   PMID:32883546   PMID:32909611   PMID:32912852   PMID:32950783   PMID:32988855   PMID:33035419   PMID:33040382  
PMID:33061818   PMID:33077622   PMID:33148838   PMID:33173103   PMID:33238997   PMID:33247673   PMID:33303547   PMID:33401590   PMID:33436266   PMID:33441663   PMID:33493738   PMID:33512337  
PMID:33512737   PMID:33522421   PMID:33570702   PMID:33576548   PMID:33605409   PMID:33655339   PMID:33686512   PMID:33711076   PMID:33725589   PMID:33863359   PMID:33903620   PMID:33961781  
PMID:33963333   PMID:33991642   PMID:34002664   PMID:34081998   PMID:34192627   PMID:34215822   PMID:34222495   PMID:34260774   PMID:34279173   PMID:34322122   PMID:34378353   PMID:34389559  
PMID:34398403   PMID:34400766   PMID:34426754   PMID:34546527   PMID:34710721   PMID:34768994   PMID:34814947   PMID:34817649   PMID:34819929   PMID:34891039   PMID:34928049   PMID:35020096  
PMID:35020525   PMID:35082281   PMID:35128637   PMID:35140704   PMID:35171696   PMID:35178710   PMID:35189144   PMID:35192530   PMID:35300329   PMID:35345353   PMID:35388602   PMID:35570080  
PMID:35679790   PMID:35715478   PMID:35758480   PMID:35820906   PMID:35840880   PMID:35926563   PMID:35994955   PMID:36142893   PMID:36164994   PMID:36260448   PMID:36264772   PMID:36334346  
PMID:36377984   PMID:36463168   PMID:36569197  


Genomics

Comparative Map Data
TLR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,684,280 - 153,710,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4153,684,070 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
T2T-CHM13v2.04157,008,777 - 157,030,716 (+)NCBIT2T-CHM13v2.0
Tlr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)EnsemblGRCm39 Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBIMGSCv36mm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
Tlr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKY
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
Tlr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBIChiLan1.0ChiLan1.0
TLR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14157,848,058 - 157,870,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,866,977 - 157,869,331 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04146,024,653 - 146,091,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TLR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,454,557 - 51,465,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,454,695 - 51,465,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,808,717 - 51,811,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,140,775 - 52,151,566 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11551,404,786 - 51,407,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,510,608 - 51,512,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,821,784 - 51,824,151 (+)NCBIUU_Cfam_GSD_1.0
Tlr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530139,016,995 - 39,024,812 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576527,434 - 529,788 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936576522,234 - 531,660 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,411,993 - 75,428,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,416,257 - 75,428,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,823,867 - 79,834,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,239,533 - 100,565,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,258,441 - 100,260,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,891,761 - 79,956,832 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248584,979,485 - 4,981,833 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TLR2
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001318789.2(TLR2):c.2258G>A (p.Arg753Gln) single nucleotide variant Mycobacterium tuberculosis, susceptibility to [RCV000033853] Chr4:153705165 [GRCh38]
Chr4:154626317 [GRCh37]
Chr4:4q31.3
risk factor
NM_001318789.2(TLR2):c.2029C>T (p.Arg677Trp) single nucleotide variant Leprosy, susceptibility to, 3 [RCV000007045] Chr4:153704936 [GRCh38]
Chr4:154626088 [GRCh37]
Chr4:4q31.3
risk factor
NG_016229.2:g.23486GT[26_43] microsatellite Colorectal cancer, susceptibility to [RCV000007046] Chr4:4q32 risk factor
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2
pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2
pathogenic
GRCh38/hg38 4q31.22-34.1(chr4:147317283-173675559)x3 copy number gain See cases [RCV000051788] Chr4:147317283..173675559 [GRCh38]
Chr4:148238435..174596710 [GRCh37]
Chr4:148457885..174833285 [NCBI36]
Chr4:4q31.22-34.1
pathogenic
GRCh38/hg38 4q31.23-35.2(chr4:148356485-189548183)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]|See cases [RCV000051789] Chr4:148356485..189548183 [GRCh38]
Chr4:149277637..190469337 [GRCh37]
Chr4:149497087..190706331 [NCBI36]
Chr4:4q31.23-35.2
pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:153656785-154928773)x1 copy number loss See cases [RCV000053324] Chr4:153656785..154928773 [GRCh38]
Chr4:154577937..155849925 [GRCh37]
Chr4:154797387..156069375 [NCBI36]
Chr4:4q31.3-32.1
pathogenic
NM_003264.3(TLR2):c.1192C>T (p.His398Tyr) single nucleotide variant Malignant melanoma [RCV000066299] Chr4:153704099 [GRCh38]
Chr4:154625251 [GRCh37]
Chr4:154844701 [NCBI36]
Chr4:4q31.3
not provided
NM_003264.3(TLR2):c.1886G>A (p.Arg629Lys) single nucleotide variant Malignant melanoma [RCV000066300] Chr4:153704793 [GRCh38]
Chr4:154625945 [GRCh37]
Chr4:154845395 [NCBI36]
Chr4:4q31.3
not provided
NM_003264.3(TLR2):c.1887G>A (p.Arg629=) single nucleotide variant Malignant melanoma [RCV000066301] Chr4:153704794 [GRCh38]
Chr4:154625946 [GRCh37]
Chr4:154845396 [NCBI36]
Chr4:4q31.3
not provided
NM_003264.3(TLR2):c.2051G>A (p.Trp684Ter) single nucleotide variant Malignant melanoma [RCV000066302] Chr4:153704958 [GRCh38]
Chr4:154626110 [GRCh37]
Chr4:154845560 [NCBI36]
Chr4:4q31.3
not provided
NM_003264.3(TLR2):c.2075C>T (p.Ser692Phe) single nucleotide variant Malignant melanoma [RCV000066303] Chr4:153704982 [GRCh38]
Chr4:154626134 [GRCh37]
Chr4:154845584 [NCBI36]
Chr4:4q31.3
not provided
NM_003264.3(TLR2):c.2239C>T (p.Gln747Ter) single nucleotide variant Malignant melanoma [RCV000066304] Chr4:153705146 [GRCh38]
Chr4:154626298 [GRCh37]
Chr4:154845748 [NCBI36]
Chr4:4q31.3
not provided
NM_001318789.2(TLR2):c.1906A>C (p.Ser636Arg) single nucleotide variant not provided [RCV000097469] Chr4:153704813 [GRCh38]
Chr4:154625965 [GRCh37]
Chr4:4q31.3
likely benign|not provided
NM_001318789.2(TLR2):c.265A>G (p.Asn89Asp) single nucleotide variant not provided [RCV000097470] Chr4:153703172 [GRCh38]
Chr4:154624324 [GRCh37]
Chr4:4q31.3
not provided
GRCh38/hg38 4q31.21-35.2(chr4:145042668-189975519)x3 copy number gain See cases [RCV000135845] Chr4:145042668..189975519 [GRCh38]
Chr4:145963820..190828225 [GRCh37]
Chr4:146183270..191133668 [NCBI36]
Chr4:4q31.21-35.2
pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:151299810-160314050)x1 copy number loss See cases [RCV000135696] Chr4:151299810..160314050 [GRCh38]
Chr4:152220962..161235202 [GRCh37]
Chr4:152440412..161454652 [NCBI36]
Chr4:4q31.3-32.1
likely pathogenic
GRCh38/hg38 4q31.1-35.2(chr4:138510532-189963195)x3 copy number gain See cases [RCV000136810] Chr4:138510532..189963195 [GRCh38]
Chr4:139431686..190828225 [GRCh37]
Chr4:139651136..191121344 [NCBI36]
Chr4:4q31.1-35.2
pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:131985253-190095391)x3 copy number gain See cases [RCV000137721] Chr4:131985253..190095391 [GRCh38]
Chr4:132906408..190828225 [GRCh37]
Chr4:133125858..191250527 [NCBI36]
Chr4:4q28.3-35.2
pathogenic|likely benign
GRCh38/hg38 4q28.1-35.1(chr4:125432943-185761887)x3 copy number gain See cases [RCV000138578] Chr4:125432943..185761887 [GRCh38]
Chr4:126354098..186683041 [GRCh37]
Chr4:126573548..186920035 [NCBI36]
Chr4:4q28.1-35.1
pathogenic|likely benign
GRCh38/hg38 4q28.3-35.2(chr4:134935616-190036318)x3 copy number gain See cases [RCV000143559] Chr4:134935616..190036318 [GRCh38]
Chr4:135856771..190957473 [GRCh37]
Chr4:136076221..191194467 [NCBI36]
Chr4:4q28.3-35.2
pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:152500649-155788803)x3 copy number gain See cases [RCV000143617] Chr4:152500649..155788803 [GRCh38]
Chr4:153421801..156709955 [GRCh37]
Chr4:153641251..156929405 [NCBI36]
Chr4:4q31.3-32.1
likely pathogenic
GRCh37/hg19 4q28.3-35.1(chr4:136912336-184253252)x3 copy number gain See cases [RCV000240245] Chr4:136912336..184253252 [GRCh37]
Chr4:4q28.3-35.1
pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.3-35.2(chr4:153890440-190957473)x3 copy number gain See cases [RCV000510713] Chr4:153890440..190957473 [GRCh37]
Chr4:4q31.3-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.3-32.2(chr4:153203431-162912359)x1 copy number loss See cases [RCV000511404] Chr4:153203431..162912359 [GRCh37]
Chr4:4q31.3-32.2
pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.3(chr4:154581208-154609523)x3 copy number gain not provided [RCV000744064] Chr4:154581208..154609523 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_001318789.2(TLR2):c.650T>C (p.Phe217Ser) single nucleotide variant not provided [RCV000882369] Chr4:153703557 [GRCh38]
Chr4:154624709 [GRCh37]
Chr4:4q31.3
benign
NM_001318789.2(TLR2):c.1722G>A (p.Gln574=) single nucleotide variant not provided [RCV000898430] Chr4:153704629 [GRCh38]
Chr4:154625781 [GRCh37]
Chr4:4q31.3
likely benign
NM_001318789.2(TLR2):c.1221G>A (p.Glu407=) single nucleotide variant not provided [RCV000927553] Chr4:153704128 [GRCh38]
Chr4:154625280 [GRCh37]
Chr4:4q31.3
likely benign
NM_001318789.2(TLR2):c.114C>A (p.Gly38=) single nucleotide variant not provided [RCV000968045] Chr4:153703021 [GRCh38]
Chr4:154624173 [GRCh37]
Chr4:4q31.3
benign
NM_001318789.2(TLR2):c.1736G>A (p.Arg579His) single nucleotide variant not provided [RCV000888096] Chr4:153704643 [GRCh38]
Chr4:154625795 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3-32.1(chr4:153061243-157994448)x1 copy number loss not provided [RCV001005606] Chr4:153061243..157994448 [GRCh37]
Chr4:4q31.3-32.1
likely pathogenic
GRCh37/hg19 4q28.1-35.1(chr4:124873497-185278662)x3 copy number gain not provided [RCV000849686] Chr4:124873497..185278662 [GRCh37]
Chr4:4q28.1-35.1
pathogenic
Single allele duplication not provided [RCV000845041] Chr4:154239914..155235547 [GRCh37]
Chr4:4q31.3
not provided
GRCh37/hg19 4q31.3-35.2(chr4:151174061-190957473)x3 copy number gain not provided [RCV000849098] Chr4:151174061..190957473 [GRCh37]
Chr4:4q31.3-35.2
pathogenic
NM_001318789.2(TLR2):c.639G>C (p.Leu213=) single nucleotide variant not provided [RCV000916761] Chr4:153703546 [GRCh38]
Chr4:154624698 [GRCh37]
Chr4:4q31.3
benign
NM_001318789.2(TLR2):c.489T>A (p.Thr163=) single nucleotide variant not provided [RCV000892175] Chr4:153703396 [GRCh38]
Chr4:154624548 [GRCh37]
Chr4:4q31.3
likely benign
NM_001318789.2(TLR2):c.1712G>A (p.Arg571His) single nucleotide variant not provided [RCV000897076] Chr4:153704619 [GRCh38]
Chr4:154625771 [GRCh37]
Chr4:4q31.3
likely benign
NM_001318789.2(TLR2):c.271A>G (p.Ile91Val) single nucleotide variant not provided [RCV000889528] Chr4:153703178 [GRCh38]
Chr4:154624330 [GRCh37]
Chr4:4q31.3
likely benign
NM_001318789.2(TLR2):c.1626C>G (p.Leu542=) single nucleotide variant Leprosy, susceptibility to, 3 [RCV002505430]|not provided [RCV000956261] Chr4:153704533 [GRCh38]
Chr4:154625685 [GRCh37]
Chr4:4q31.3
benign|likely benign
NM_001318789.2(TLR2):c.582G>C (p.Leu194Phe) single nucleotide variant Hereditary angioedema with normal C1Inh [RCV001027421] Chr4:153703489 [GRCh38]
Chr4:154624641 [GRCh37]
Chr4:4q31.3
not provided
GRCh37/hg19 4q31.3(chr4:154306552-154914180)x3 copy number gain not provided [RCV001259875] Chr4:154306552..154914180 [GRCh37]
Chr4:4q31.3
likely benign
NM_001318789.2(TLR2):c.1340G>A (p.Arg447Gln) single nucleotide variant Leprosy, susceptibility to, 3 [RCV001281049] Chr4:153704247 [GRCh38]
Chr4:154625399 [GRCh37]
Chr4:4q31.3
uncertain significance
NM_001318789.2(TLR2):c.119C>T (p.Ser40Leu) single nucleotide variant not provided [RCV001356108] Chr4:153703026 [GRCh38]
Chr4:154624178 [GRCh37]
Chr4:4q31.3
uncertain significance
GRCh37/hg19 4q28.3-32.3(chr4:131303317-168722402)x3 copy number gain not provided [RCV001537926] Chr4:131303317..168722402 [GRCh37]
Chr4:4q28.3-32.3
pathogenic
Single allele duplication not provided [RCV001357465] Chr4:153681398..153681399 [GRCh38]
Chr4:154602550..154602551 [GRCh37]
Chr4:4q31.3
uncertain significance
NM_001318789.2(TLR2):c.2296A>G (p.Met766Val) single nucleotide variant not provided [RCV001355091] Chr4:153705203 [GRCh38]
Chr4:154626355 [GRCh37]
Chr4:4q31.3
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR19Ahsa-miR-19a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22105995
MIR105-2hsa-miR-105-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19509287
MIR19B2hsa-miR-19b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22105995
MIR19B1hsa-miR-19b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22105995
MIR146Ahsa-miR-146a-5pTarbaseexternal_infoqPCRPOSITIVE
MIR146Ahsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//flow//Luciferase reporter assay//Western Functional MTI20375304

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:122
Interacting mature miRNAs:125
Transcripts:ENST00000260010
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G34296  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,501 - 154,626,693UniSTSGRCh37
Build 364154,845,951 - 154,846,143RGDNCBI36
Celera4151,950,988 - 151,951,180RGD
Cytogenetic Map4q32UniSTS
HuRef4150,357,526 - 150,357,718UniSTS
D4S660  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,618,362 - 154,618,518UniSTSGRCh37
Build 364154,837,812 - 154,837,968RGDNCBI36
Celera4151,942,849 - 151,943,005RGD
Cytogenetic Map4q32UniSTS
HuRef4150,349,379 - 150,349,535UniSTS
TNG Radiation Hybrid Map492560.0UniSTS
PMC128073P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,624,134 - 154,624,425UniSTSGRCh37
Build 364154,843,584 - 154,843,875RGDNCBI36
Celera4151,948,621 - 151,948,912RGD
Cytogenetic Map4q32UniSTS
HuRef4150,355,159 - 150,355,450UniSTS
PMC201071P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,015 - 154,626,090UniSTSGRCh37
GRCh374154,600,967 - 154,601,042UniSTSGRCh37
Build 364154,820,417 - 154,820,492RGDNCBI36
Celera4151,950,502 - 151,950,577UniSTS
Celera4151,925,453 - 151,925,528RGD
Cytogenetic Map4q32UniSTS
HuRef4150,331,976 - 150,332,051UniSTS
HuRef4150,357,040 - 150,357,115UniSTS
PMC37511P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,625,713 - 154,626,059UniSTSGRCh37
Build 364154,845,163 - 154,845,509RGDNCBI36
Celera4151,950,200 - 151,950,546RGD
Cytogenetic Map4q32UniSTS
HuRef4150,356,738 - 150,357,084UniSTS
PMC55404P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,624,284 - 154,624,539UniSTSGRCh37
Build 364154,843,734 - 154,843,989RGDNCBI36
Celera4151,948,771 - 151,949,026RGD
Cytogenetic Map4q32UniSTS
HuRef4150,355,309 - 150,355,564UniSTS
PMC97725P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,033 - 154,626,462UniSTSGRCh37
Build 364154,845,483 - 154,845,912RGDNCBI36
Celera4151,950,520 - 151,950,949RGD
Cytogenetic Map4q32UniSTS
HuRef4150,357,058 - 150,357,487UniSTS
PMC98129P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,624,250 - 154,624,615UniSTSGRCh37
Build 364154,843,700 - 154,844,065RGDNCBI36
Celera4151,948,737 - 151,949,102RGD
Cytogenetic Map4q32UniSTS
HuRef4150,355,275 - 150,355,640UniSTS
PMC98226P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,625,911 - 154,626,388UniSTSGRCh37
Build 364154,845,361 - 154,845,838RGDNCBI36
Celera4151,950,398 - 151,950,875RGD
Cytogenetic Map4q32UniSTS
HuRef4150,356,936 - 150,357,413UniSTS
PMC98510P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,037 - 154,626,419UniSTSGRCh37
Build 364154,845,487 - 154,845,869RGDNCBI36
Celera4151,950,524 - 151,950,906RGD
Cytogenetic Map4q32UniSTS
HuRef4150,357,062 - 150,357,444UniSTS
AF368419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,211 - 154,626,328UniSTSGRCh37
Build 364154,845,661 - 154,845,778RGDNCBI36
Celera4151,950,698 - 151,950,815RGD
HuRef4150,357,236 - 150,357,353UniSTS
TLR2_1084.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,625,906 - 154,626,740UniSTSGRCh37
Build 364154,845,356 - 154,846,190RGDNCBI36
Celera4151,950,393 - 151,951,227RGD
HuRef4150,356,931 - 150,357,765UniSTS
D4S841  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,618,109 - 154,618,277UniSTSGRCh37
Build 364154,837,559 - 154,837,727RGDNCBI36
Celera4151,942,596 - 151,942,764RGD
Cytogenetic Map4q32UniSTS
HuRef4150,349,126 - 150,349,294UniSTS
TNG Radiation Hybrid Map492556.0UniSTS
D4S575  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,618,800 - 154,618,948UniSTSGRCh37
Build 364154,838,250 - 154,838,398RGDNCBI36
Celera4151,943,287 - 151,943,435RGD
Cytogenetic Map4q32UniSTS
HuRef4150,349,817 - 150,349,965UniSTS
SHGC4-1535  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,528 - 154,626,690UniSTSGRCh37
Build 364154,845,978 - 154,846,140RGDNCBI36
Celera4151,951,015 - 151,951,177RGD
Cytogenetic Map4q32UniSTS
HuRef4150,357,553 - 150,357,715UniSTS
TNG Radiation Hybrid Map492564.0UniSTS
SHGC-33147  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,626,392 - 154,626,541UniSTSGRCh37
Build 364154,845,842 - 154,845,991RGDNCBI36
Celera4151,950,879 - 151,951,028RGD
Cytogenetic Map4q32UniSTS
HuRef4150,357,417 - 150,357,566UniSTS
TNG Radiation Hybrid Map492564.0UniSTS
Stanford-G3 RH Map48464.0UniSTS
GeneMap99-GB4 RH Map4638.84UniSTS
Whitehead-RH Map4686.3UniSTS
GeneMap99-G3 RH Map48389.0UniSTS
TLR2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374154,600,992 - 154,601,220UniSTSGRCh37
GRCh374154,626,040 - 154,626,268UniSTSGRCh37
Celera4151,925,478 - 151,925,706UniSTS
Celera4151,950,527 - 151,950,755UniSTS
HuRef4150,357,065 - 150,357,293UniSTS
HuRef4150,332,001 - 150,332,229UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 431 1685 406 195 1180 78 1574 146 852 123 287 817 120 898 987 1
Low 1919 1256 1293 411 527 368 2622 1860 2585 285 1114 663 51 306 1690 1
Below cutoff 28 43 15 12 146 13 132 165 229 4 23 61 111

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047416114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB445624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC106865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF502291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI493140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125659