CCL7 (C-C motif chemokine ligand 7) - Rat Genome Database

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Gene: CCL7 (C-C motif chemokine ligand 7) Homo sapiens
Analyze
Symbol: CCL7
Name: C-C motif chemokine ligand 7
RGD ID: 1352377
HGNC Page HGNC:10634
Description: Enables CCR1 chemokine receptor binding activity and chemokine activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of natural killer cell chemotaxis; and regulation of cell shape. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in multiple sclerosis. Biomarker of several diseases, including autoimmune disease (multiple); lung disease (multiple); nose disease (multiple); periapical periodontitis (multiple); and viral infectious disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C motif chemokine 7; chemokine (C-C motif) ligand 7; FIC; MARC; MCP-3; MCP3; MGC138463; MGC138465; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; NC28; SCYA6; SCYA7; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7
RGD Orthologs
Mouse
Rat
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,270,221 - 34,272,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,597,240 - 32,599,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,621,353 - 29,623,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,621,352 - 29,623,368NCBI
Celera1729,507,053 - 29,509,069 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,782,528 - 28,784,554 (+)NCBIHuRef
CHM1_11732,661,096 - 32,663,122 (+)NCBICHM1_1
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
CCL7Humanallergic conjunctivitis  IEP 6483824protein:increased expression:conjunctivaRGD 
CCL7Humanasthma  ISOCcl7 (Mus musculus)5130979 RGD 
CCL7Humanasthma  IEP 5130983Promoter polymorphismRGD 
CCL7HumanBronchial Hyperreactivity  ISOCcl7 (Mus musculus)5130980 RGD 
CCL7Humanbronchiolitis obliterans  ISOCcl7 (Rattus norvegicus)6483763protein:increased expression:bronchoalveolar Lavage fluidRGD 
CCL7Humanbronchopulmonary dysplasia  ISOCcl7 (Mus musculus)5130981 RGD 
CCL7Humanchronic obstructive pulmonary disease  IEP 6483765mRNA and protein:increased expression:macrophageRGD 
CCL7HumanChronic Periodontitis disease_progressionIEP 6483776protein:increased expression:gingival crevicular fluid and gingviaRGD 
CCL7HumanCOVID-19  HEP 30296672mRNA:increased expression:bronchoalveolar lavage (human)RGD 
CCL7HumanCOVID-19 severityIEP 30309209protein:increased expression:plasma (human)RGD 
CCL7Humanethmoid sinusitis  IEP 6483785protein:increased expression:ethmoid sinusRGD 
CCL7HumanExperimental Arthritis onsetISOCcl7 (Mus musculus)6483780 RGD 
CCL7HumanExperimental Liver Cirrhosis  ISOCcl7 (Rattus norvegicus)6483766 RGD 
CCL7Humanextrinsic allergic alveolitis  ISOCcl7 (Mus musculus)5130978 RGD 
CCL7HumanFungal Lung Diseases  ISOCcl7 (Mus musculus)5129686 RGD 
CCL7Humanglomerulonephritis  ISOCcl7 (Rattus norvegicus)8693624 RGD 
CCL7HumanLiver Reperfusion Injury amelioratesISOCcl7 (Mus musculus)329902072 RGD 
CCL7Humanmultiple sclerosis  IEP 6483814mRNA and protein:increased expression:brainRGD 
CCL7Humanmultiple sclerosis  IAGP 6483818DNA:polymorphism:promoterRGD 
CCL7Humanmyocarditis  ISOCcl7 (Mus musculus)6483771 RGD 
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Original Reference(s)
CCL7HumanNeurodevelopmental Disorders  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
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Original Reference(s)
CCL7Humanallergic disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
CCL7Humancholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21224055
CCL7Humanglomerulonephritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:10385480
CCL7Humaninterstitial nephritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:10385480
CCL7Humanmalignant mesothelioma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25162674
CCL7Humanmiddle cerebral artery infarction  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12374626
CCL7Humanpneumonia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544

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Original Reference(s)
CCL7Human1,2-dimethylhydrazine increases expressionISOCcl7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of CCL7 mRNACTDPMID:22206623
CCL7Human1,4-phenylenediamine increases expressionEXP 64804644-phenylenediamine results in increased expression of CCL7 mRNACTDPMID:27585668
CCL7Human1-chloro-2,4-dinitrobenzene increases expressionISOCcl7 (Rattus norvegicus)6480464Dinitrochlorobenzene results in increased expression of CCL7 mRNACTDPMID:21893156
CCL7Human1-chloro-2,4-dinitrobenzene increases expressionISOCcl7 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of CCL7 mRNACTDPMID:19647056 and PMID:21404309
CCL7Human15-acetyldeoxynivalenol increases expressionISOCcl7 (Mus musculus)648046415-acetyldeoxynivalenol results in increased expression of CCL7 mRNACTDPMID:24793808
CCL7Human17alpha-ethynylestradiol affects expressionISOCcl7 (Rattus norvegicus)6480464Ethinyl Estradiol affects the expression of CCL7 mRNACTDPMID:15212814
CCL7Human17beta-estradiol affects expressionISOCcl7 (Mus musculus)6480464Estradiol affects the expression of CCL7 mRNACTDPMID:15598610
CCL7Human17beta-estradiol multiple interactionsISOCcl7 (Rattus norvegicus)6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCL7 mRNACTDPMID:32741896
CCL7Human17beta-estradiol increases expressionISOCcl7 (Mus musculus)6480464Estradiol results in increased expression of CCL7 mRNACTDPMID:19484750
CCL7Human17beta-estradiol increases expressionISOCcl7 (Rattus norvegicus)6480464Estradiol results in increased expression of CCL7 mRNACTDPMID:17010207
CCL7Human17beta-estradiol 3-benzoate multiple interactionsISOCcl7 (Rattus norvegicus)6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCL7 mRNACTDPMID:32741896
CCL7Human2,2',4,4',5,5'-hexachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:23146750
CCL7Human2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:23146750
CCL7Human2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOCcl7 (Rattus norvegicus)64804642 more ...CTDPMID:27291303
CCL7Human2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:36804509
CCL7Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCcl7 (Mus musculus)6480464Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CCL7 mRNA]CTDPMID:15667827
CCL7Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCcl7 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of CCL7 mRNACTDPMID:33387578 and PMID:34747641
CCL7Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCcl7 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CCL7 mRNACTDPMID:29673856
CCL7Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCcl7 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CCL7 mRNACTDPMID:21570461
CCL7Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CCL7 mRNACTDPMID:21296121

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Biological Process
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Original Reference(s)
CCL7Humanantimicrobial humoral immune response mediated by antimicrobial peptide involved_inIBAPANTHER:PTN000245709 more ...150520179 GO_CentralGO_REF:0000033
CCL7Humancell-cell signaling involved_inTAS 150520179 PMID:7916328PINCPMID:7916328
CCL7Humancellular response to ethanol  ISOCcl7 (Rattus norvegicus)9068941 RGDPMID:12235260 and REF_RGD_ID:6483767
CCL7Humancellular response to ethanol involved_inIEAUniProtKB:Q9QXY8 and ensembl:ENSRNOP00000000256150520179 EnsemblGO_REF:0000107
CCL7Humanchemokine-mediated signaling pathway involved_inIBAMGI:1349183 more ...150520179 GO_CentralGO_REF:0000033
CCL7Humanchemotaxis involved_inTAS 150520179 PMID:9780207PINCPMID:9780207
CCL7Humanchemotaxis involved_inIEAUniProtKB-KW:KW-0145150520179 UniProtGO_REF:0000043
CCL7Humancytoskeleton organization involved_inIDA 150520179 PMID:10072545UniProtPMID:10072545
CCL7Humaneosinophil chemotaxis involved_inIDA 150520179 PMID:10072545UniProtPMID:10072545
CCL7Humaneosinophil chemotaxis involved_inIBAPANTHER:PTN008532501 more ...150520179 GO_CentralGO_REF:0000033
CCL7Humanimmune response involved_inIEAInterPro:IPR000827 more ...150520179 InterProGO_REF:0000002
CCL7Humaninflammatory response involved_inIEAUniProtKB-KW:KW-0395150520179 UniProtGO_REF:0000043
CCL7Humaninflammatory response involved_inIBAMGI:108224 more ...150520179 GO_CentralGO_REF:0000033
CCL7Humanintracellular calcium ion homeostasis involved_inTAS 150520179 PMID:10770925PINCPMID:10770925
CCL7Humanmonocyte chemotaxis involved_inICGO:0031726150520179 PMID:10660125UniProtPMID:10660125
CCL7Humanpositive regulation of cell migration involved_inIDA 150520179 PMID:7545673UniProtPMID:7545673
CCL7Humanpositive regulation of cell migration involved_inIBAMGI:104593 more ...150520179 GO_CentralGO_REF:0000033
CCL7Humanpositive regulation of natural killer cell chemotaxis involved_inIDA 150520179 PMID:7545673UniProtPMID:7545673
CCL7Humanregulation of cell shape involved_inIDA 150520179 PMID:10072545UniProtPMID:10072545
CCL7Humanresponse to gamma radiation involved_inIEAUniProtKB:Q9QXY8 and ensembl:ENSRNOP00000000256150520179 EnsemblGO_REF:0000107
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Cellular Component

  
Object Symbol
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Original Reference(s)
CCL7Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
CCL7Humanextracellular region located_inIEAInterPro:IPR000827 more ...150520179 InterProGO_REF:0000002
CCL7Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
CCL7Humanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-443986
CCL7Humanextracellular space located_inIEAUniProtKB:Q03366 and ensembl:ENSMUSP00000021011150520179 EnsemblGO_REF:0000107
CCL7Humanextracellular space is_active_inIBAMGI:101878 more ...150520179 GO_CentralGO_REF:0000033
CCL7Humanextracellular space located_inTAS 150520179 PMID:7916328PINCPMID:7916328
CCL7Humanextracellular space located_inIEAUniProtKB-KW:KW-0202150520179 UniProtGO_REF:0000043

Molecular Function
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Reference Title
Reference Citation
1. Chemokines in the limbal form of vernal keratoconjunctivitis. Abu El-Asrar AM, etal., Br J Ophthalmol. 2000 Dec;84(12):1360-6.
2. Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis. Adarichev VA, etal., Autoimmunity. 2006 Dec;39(8):663-73.
3. Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population. Batra J, etal., J Allergy Clin Immunol. 2011 Mar 8.
4. IL-1beta disrupts postnatal lung morphogenesis in the mouse. Bry K, etal., Am J Respir Cell Mol Biol. 2007 Jan;36(1):32-42. Epub 2006 Aug 3.
5. Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Choi ES, etal., Am J Respir Crit Care Med. 2004 Sep 1;170(5):508-15. Epub 2004 Jun 10.
6. Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis. Dezerega A, etal., Int Endod J. 2010 Oct;43(10):902-8. doi: 10.1111/j.1365-2591.2010.01764.x. Epub 2010 Jul 15.
7. Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis. Dezerega A, etal., J Periodontol. 2010 Feb;81(2):267-76.
8. Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma. Dharajiya N, etal., PLoS One. 2009 Dec 21;4(12):e8172.
9. Chemokine expression by small sputum macrophages in COPD. Frankenberger M, etal., Mol Med. 2011;17(7-8):762-70. doi: 10.2119/molmed.2010.00202. Epub 2011 Feb 9.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation. Gu N, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L290-6. Epub 2009 Dec 4.
12. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
13. Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis. Langley RJ, etal., J Toxicol Environ Health A. 2011;74(19):1261-79.
14. Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Luesink M, etal., Blood. 2009 Dec 24;114(27):5512-21. Epub 2009 Oct 14.
15. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study. McManus C, etal., J Neuroimmunol. 1998 Jun 1;86(1):20-9.
16. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. Morgan DL, etal., Toxicol Pathol. 2012 Apr;40(3):448-65. Epub 2012 Jan 3.
17. Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis. Nelissen I, etal., J Neurol Sci. 2002 Aug 15;200(1-2):43-8.
18. Effective methylprednisolone dose in experimental crescentic glomerulonephritis. Ou ZL, etal., Am J Kidney Dis. 2001 Feb;37(2):411-7.
19. Transient and sequential expression of chemokine mRNA in glomeruli in puromycin aminonucleoside nephrosis. Ou ZL, etal., Nephron. 2000 Jul;85(3):254-7.
20. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. Patsouras MD, etal., J Autoimmun. 2015 Dec;65:30-7. doi: 10.1016/j.jaut.2015.08.001. Epub 2015 Aug 15.
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PMID:1613466   PMID:7545673   PMID:7916328   PMID:8318676   PMID:8461011   PMID:8530354   PMID:8580362   PMID:8642344   PMID:8898111   PMID:9109648   PMID:9346360   PMID:9364936  
PMID:9405404   PMID:9780207   PMID:9789057   PMID:10072545   PMID:10201901   PMID:10205198   PMID:10477718   PMID:10525044   PMID:10570327   PMID:10660125   PMID:10734104   PMID:10770925  
PMID:10947989   PMID:11146155   PMID:11781181   PMID:12098517   PMID:12149192   PMID:12477932   PMID:12539042   PMID:12847692   PMID:13679391   PMID:14571188   PMID:14733956   PMID:15067078  
PMID:15194816   PMID:15340161   PMID:15381085   PMID:15489334   PMID:15715950   PMID:16002730   PMID:16169070   PMID:17023422   PMID:17364026   PMID:17703412   PMID:18469140   PMID:18533557  
PMID:18660381   PMID:19253530   PMID:19258923   PMID:19322201   PMID:19403065   PMID:19423540   PMID:19424580   PMID:19526283   PMID:19865101   PMID:19898927   PMID:19937793   PMID:20056178  
PMID:20237496   PMID:20406964   PMID:20438785   PMID:20503287   PMID:20570966   PMID:20628624   PMID:21072187   PMID:21102463   PMID:21148795   PMID:21279498   PMID:21536288   PMID:21873635  
PMID:22412388   PMID:22468089   PMID:22614322   PMID:23762028   PMID:23764760   PMID:24327013   PMID:24578274   PMID:24727473   PMID:24742347   PMID:25193015   PMID:25261323   PMID:25416956  
PMID:26095031   PMID:26756352   PMID:27044744   PMID:28381538   PMID:28475003   PMID:30764543   PMID:31034889   PMID:32060844   PMID:32217106   PMID:32296183   PMID:32694731   PMID:33257678  
PMID:33318472   PMID:33876413   PMID:35715847   PMID:36118415   PMID:36274485   PMID:36398464   PMID:36585204   PMID:38316963   PMID:38914803   PMID:39231238  



CCL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,270,221 - 34,272,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,597,240 - 32,599,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,621,353 - 29,623,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,621,352 - 29,623,368NCBI
Celera1729,507,053 - 29,509,069 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,782,528 - 28,784,554 (+)NCBIHuRef
CHM1_11732,661,096 - 32,663,122 (+)NCBICHM1_1
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBIT2T-CHM13v2.0
Ccl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,936,538 - 81,938,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,936,538 - 81,938,351 (+)EnsemblGRCm39 Ensembl
GRCm381182,045,712 - 82,047,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,045,712 - 82,047,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,859,214 - 81,861,027 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,861,909 - 81,863,720 (+)NCBIMGSCv36mm8
Celera1191,659,161 - 91,660,974 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.83NCBI
Ccl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,514,095 - 67,515,945 (+)NCBIGRCr8
mRatBN7.21067,016,446 - 67,018,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,016,446 - 67,018,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,637,651 - 71,639,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,143,000 - 71,144,850 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,604,125 - 66,605,975 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,423,083 - 69,424,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,423,086 - 69,424,979 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,058,109 - 69,059,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,267,281 - 70,269,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,280,903 - 70,282,754 (+)NCBI
Celera1065,963,980 - 65,965,830 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,994,638 - 38,996,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,993,911 - 39,010,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,217,925 - 38,219,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,808,818 - 39,810,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,808,231 - 39,824,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1938,595,171 - 38,596,636 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,875,478 - 38,879,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,963,214 - 38,964,679 (-)NCBIUU_Cfam_GSD_1.0
CCL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,777,795 - 27,780,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660752,239,664 - 2,241,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in CCL7
8 total Variants

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Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 17q12(chr17:33642695-34549211)x3 copy number gain See cases [RCV000054013] Chr17:33642695..34549211 [GRCh38]
Chr17:31969714..32876230 [GRCh37]
Chr17:28993827..29900343 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33670906-34596087)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|See cases [RCV000054042] Chr17:33670906..34596087 [GRCh38]
Chr17:31997925..32923106 [GRCh37]
Chr17:29022038..29947219 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33715517-34301601)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|See cases [RCV000054043] Chr17:33715517..34301601 [GRCh38]
Chr17:32042536..32628620 [GRCh37]
Chr17:29066649..29652733 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33777728-34301601)x3 copy number gain See cases [RCV000135956] Chr17:33777728..34301601 [GRCh38]
Chr17:32104747..32628620 [GRCh37]
Chr17:29128860..29652733 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33671097-34595982)x3 copy number gain See cases [RCV000139003] Chr17:33671097..34595982 [GRCh38]
Chr17:31998116..32923001 [GRCh37]
Chr17:29022229..29947114 [NCBI36]
Chr17:17q12
likely benign
GRCh38/hg38 17q12(chr17:33671106-34595887)x3 copy number gain See cases [RCV000140285] Chr17:33671106..34595887 [GRCh38]
Chr17:31998125..32922906 [GRCh37]
Chr17:29022238..29947019 [NCBI36]
Chr17:17q12
likely benign
GRCh37/hg19 17q12(chr17:31982779-32917705)x3 copy number gain See cases [RCV000449299] Chr17:31982779..32917705 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000445952] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000511904] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:32064314-32643063)x3 copy number gain See cases [RCV000511568] Chr17:32064314..32643063 [GRCh37]
Chr17:17q12
uncertain significance
1 to 10 of 29 rows

Predicted Target Of
Summary Value
Count of predictions:713
Count of miRNA genes:202
Interacting mature miRNAs:216
Transcripts:ENST00000200307, ENST00000378569, ENST00000394627, ENST00000394630
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298406BP16_HBlood pressure QTL 16 (human)0.0004Blood pressurehypertension susceptibility171477864740778647Human

GDB:607772  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,597,319 - 32,597,613UniSTSGRCh37
Build 361729,621,432 - 29,621,726RGDNCBI36
Celera1729,507,132 - 29,507,426RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,782,612 - 28,782,906UniSTS
PMC115222P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,598,235 - 32,598,778UniSTSGRCh37
Build 361729,622,348 - 29,622,891RGDNCBI36
Celera1729,508,048 - 29,508,591RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,783,528 - 28,784,071UniSTS
D17S2013  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,599,123 - 32,599,236UniSTSGRCh37
Build 361729,623,236 - 29,623,349RGDNCBI36
Celera1729,508,936 - 29,509,049RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,784,416 - 28,784,529UniSTS
GeneMap99-GB4 RH Map17289.14UniSTS
Whitehead-RH Map17307.0UniSTS
Whitehead-YAC Contig Map17 UniSTS
CCL7_3334  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,598,720 - 32,599,304UniSTSGRCh37
Build 361729,622,833 - 29,623,417RGDNCBI36
Celera1729,508,533 - 29,509,117RGD
HuRef1728,784,013 - 28,784,597UniSTS
UniSTS:480900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,597,260 - 32,598,871UniSTSGRCh37
Celera1729,507,073 - 29,508,684UniSTS
HuRef1728,782,553 - 28,784,164UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
757 963 600 909 946 747 1212 3 210 391 141 829 2592 2608 20 480 458 661 911 72



Ensembl Acc Id: ENST00000378569   ⟹   ENSP00000367832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)Ensembl
Ensembl Acc Id: ENST00000394627   ⟹   ENSP00000378124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,270,224 - 34,272,078 (+)Ensembl
Ensembl Acc Id: ENST00000394630   ⟹   ENSP00000378126
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,270,224 - 34,272,240 (+)Ensembl
RefSeq Acc Id: NM_006273   ⟹   NP_006264
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,270,221 - 34,272,242 (+)NCBI
GRCh371732,597,235 - 32,599,261 (+)NCBI
Build 361729,621,353 - 29,623,369 (+)NCBI Archive
HuRef1728,782,528 - 28,784,554 (+)NCBI
CHM1_11732,661,096 - 32,663,122 (+)NCBI
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBI
Sequence:
RefSeq Acc Id: NP_006264   ⟸   NM_006273
- Peptide Label: precursor
- UniProtKB: Q569J6 (UniProtKB/Swiss-Prot),   P80098 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000367832   ⟸   ENST00000378569
Ensembl Acc Id: ENSP00000378124   ⟸   ENST00000394627
Ensembl Acc Id: ENSP00000378126   ⟸   ENST00000394630

Name Modeler Protein Id AA Range Protein Structure
AF-P80098-F1-model_v2 AlphaFold P80098 1-99 view protein structure

RGD ID:7234585
Promoter ID:EPDNEW_H23038
Type:multiple initiation site
Name:CCL7_1
Description:C-C motif chemokine ligand 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,270,221 - 34,270,281EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
COSMIC CCL7 COSMIC
Ensembl Genes ENSG00000108688 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000378569 ENTREZGENE
  ENST00000378569.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000108688 GTEx
HGNC ID HGNC:10634 ENTREZGENE
Human Proteome Map CCL7 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:6354 UniProtKB/Swiss-Prot
NCBI Gene 6354 ENTREZGENE
OMIM 158106 OMIM
PANTHER C-C MOTIF CHEMOKINE 7 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35566 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A8MVH1_HUMAN UniProtKB/TrEMBL
  A8MX17_HUMAN UniProtKB/TrEMBL
  CCL7_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q569J6 ENTREZGENE
UniProt Secondary Q569J6 UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL7  C-C motif chemokine ligand 7  CCL7  chemokine (C-C motif) ligand 7  Symbol and/or name change 5135510 APPROVED