RGD Reference Report - Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. - Rat Genome Database

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Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia.

Authors: Choi, ES  Jakubzick, C  Carpenter, KJ  Kunkel, SL  Evanoff, H  Martinez, FJ  Flaherty, KR  Toews, GB  Colby, TV  Kazerooni, EA  Gross, BH  Travis, WD  Hogaboam, CM 
Citation: Choi ES, etal., Am J Respir Crit Care Med. 2004 Sep 1;170(5):508-15. Epub 2004 Jun 10.
RGD ID: 5130985
Pubmed: PMID:15191918   (View Abstract at PubMed)
DOI: DOI:10.1164/rccm.200401-002OC   (Journal Full-text)

Chemokines are increased and may exert effects on both inflammatory and remodeling events in idiopathic pulmonary pneumonia (IIP). Accordingly, we examined the concomitant expression of inflammatory CC chemotactic cytokines or chemokines and their corresponding receptors in surgical lung biopsies obtained at the time of disease diagnosis and pulmonary fibroblasts grown from these biopsies. By gene array analysis, upper and lower lobe biopsies and primary fibroblast lines from patients with usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia, and respiratory bronchiolitis-interstitial lung disease, but not patients without IIP, exhibited CCL7 gene expression. TAQMAN, immunohistochemical, and ELISA analyses confirmed that CCL7 was expressed at significantly higher levels in UIP lung biopsies compared with biopsies from patients with nonspecific interstitial pneumonia, respiratory bronchiolitis-interstitial lung disease, and from patients without IIP. Higher levels of CCL7 were present in cultures of IIP fibroblasts compared with non-IIP fibroblasts, and CCL5, a CCR5 agonist, significantly increased the synthesis of CCL7 by UIP fibroblasts. Together, these data suggest that CCL7 is highly expressed in biopsies and pulmonary fibroblast lines obtained from patients with UIP relative to patients with other IIP and patients without IIP, and that this CC chemokine may have a major role in the progression of fibrosis in this IIP patient group.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pneumonia  IEP 5130985 RGD 
pneumonia  ISOCCL7 (Homo sapiens)5130985; 5130985 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl7  (C-C motif chemokine ligand 7)

Genes (Mus musculus)
Ccl7  (C-C motif chemokine ligand 7)

Genes (Homo sapiens)
CCL7  (C-C motif chemokine ligand 7)


Additional Information