CCN1 (cellular communication network factor 1) - Rat Genome Database
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Gene: CCN1 (cellular communication network factor 1) Homo sapiens
Analyze
Symbol: CCN1
Name: cellular communication network factor 1
RGD ID: 731720
HGNC Page HGNC
Description: Predicted to have heparin binding activity and integrin binding activity. Involved in several processes, including positive regulation of ossification; positive regulation of osteoblast proliferation; and regulation of protein phosphorylation. Localizes to collagen-containing extracellular matrix.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCN family member 1; CYR61; cysteine rich angiogenic inducer 61; cysteine rich protein 61; cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP-10; IGFBP10; insulin-like growth factor-binding protein 10
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl185,580,761 - 85,584,589 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl185,580,761 - 85,583,950 (+)EnsemblGRCh38hg38GRCh38
GRCh38185,580,761 - 85,583,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37186,046,444 - 86,049,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,819,048 - 85,821,978 (+)NCBINCBI36hg18NCBI36
Build 34185,758,480 - 85,761,410NCBI
Celera184,290,551 - 84,293,757 (+)NCBI
Cytogenetic Map1p22.3NCBI
HuRef184,157,232 - 84,160,438 (+)NCBIHuRef
CHM1_1186,161,864 - 86,165,070 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (EXP)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
ampicillin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
avobenzone  (EXP)
azathioprine  (EXP)
bacitracin  (ISO)
bazedoxifene  (EXP)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
calciol  (ISO)
calcitriol  (EXP)
capecitabine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
casticin  (ISO)
chelerythrine  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cumene  (ISO)
cyanidin cation  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (EXP)
doxifluridine  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (EXP)
estriol  (ISO)
ethanol  (EXP)
fenamidone  (ISO)
fenofibrate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geranylgeraniol  (EXP)
glucose  (ISO)
glycidol  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
indole-3-methanol  (ISO)
irinotecan  (EXP)
jaspamide  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
menadione  (EXP)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
nickel atom  (EXP,ISO)
nicotine  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (EXP)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP)
piroxicam  (EXP)
potassium dichromate  (EXP)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
rifampicin  (EXP)
ritodrine  (ISO)
rotenone  (ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
succimer  (EXP,ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
torcetrapib  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
troglitazone  (EXP)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
verteporfin  (EXP,ISO)
vinclozolin  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process involved in heart morphogenesis  (IEA)
atrial septum morphogenesis  (IEA)
atrioventricular valve morphogenesis  (IEA)
cell adhesion  (IBA)
cell-cell adhesion  (ISO)
cellular protein metabolic process  (TAS)
chemotaxis  (IEA)
chondroblast differentiation  (IEA)
chorio-allantoic fusion  (IEA)
extracellular matrix organization  (IEA)
intussusceptive angiogenesis  (IEA)
labyrinthine layer blood vessel development  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cell death  (IBA)
osteoblast differentiation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of BMP signaling pathway  (IGI)
positive regulation of bone mineralization  (IDA)
positive regulation of cartilage development  (IEA)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (IDA)
positive regulation of cell-substrate adhesion  (IEA)
positive regulation of ceramide biosynthetic process  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of osteoblast proliferation  (IDA)
positive regulation of phospholipase activity  (IEA)
positive regulation of protein kinase activity  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
post-translational protein modification  (TAS)
reactive oxygen species metabolic process  (IEA)
regulation of ERK1 and ERK2 cascade  (IDA)
signal transduction  (IBA)
ventricular septum development  (IEA)
wound healing, spreading of cells  (IDA)

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8125298   PMID:8635876   PMID:9135077   PMID:9446626   PMID:9488038   PMID:9528960   PMID:9536281   PMID:9600969   PMID:10446209   PMID:10821835   PMID:10852911   PMID:11120741  
PMID:11287419   PMID:11584015   PMID:11600415   PMID:11751417   PMID:11810026   PMID:11840342   PMID:12036876   PMID:12217894   PMID:12364323   PMID:12374462   PMID:12444554   PMID:12477932  
PMID:12736251   PMID:12826661   PMID:12831056   PMID:12899698   PMID:12939282   PMID:14702039   PMID:14988385   PMID:15041728   PMID:15044484   PMID:15044605   PMID:15053922   PMID:15077166  
PMID:15389821   PMID:15471875   PMID:15489334   PMID:15526358   PMID:15564459   PMID:15592521   PMID:15782120   PMID:15878827   PMID:15961723   PMID:16243794   PMID:16344560   PMID:16581771  
PMID:16675545   PMID:16804865   PMID:16877350   PMID:17056474   PMID:17234971   PMID:17314511   PMID:17361185   PMID:17429007   PMID:17437852   PMID:17579708   PMID:17601910   PMID:17626014  
PMID:17673559   PMID:17699553   PMID:17718860   PMID:17765657   PMID:18004727   PMID:18025257   PMID:18058471   PMID:18089610   PMID:18202125   PMID:18212329   PMID:18575751   PMID:18599605  
PMID:18687805   PMID:18800188   PMID:18819928   PMID:18936953   PMID:18941464   PMID:18950845   PMID:19007976   PMID:19147534   PMID:19180570   PMID:19244129   PMID:19288017   PMID:19364818  
PMID:19542562   PMID:19584265   PMID:19632997   PMID:19950293   PMID:20010302   PMID:20043874   PMID:20056838   PMID:20097175   PMID:20195466   PMID:20233866   PMID:20237132   PMID:20237496  
PMID:20360068   PMID:20531301   PMID:20628624   PMID:20641097   PMID:20675382   PMID:21081514   PMID:21138874   PMID:21153366   PMID:21159247   PMID:21212405   PMID:21232118   PMID:21249313  
PMID:21312266   PMID:21349946   PMID:21393426   PMID:21397653   PMID:21447598   PMID:21488975   PMID:21505992   PMID:21601497   PMID:21618249   PMID:21628462   PMID:21711965   PMID:21873635  
PMID:21976359   PMID:21995436   PMID:22023263   PMID:22025384   PMID:22056874   PMID:22160564   PMID:22253074   PMID:22363611   PMID:22401280   PMID:22527715   PMID:22532143   PMID:22540002  
PMID:22547695   PMID:22551568   PMID:22566095   PMID:22692860   PMID:22694338   PMID:22752926   PMID:23027863   PMID:23045290   PMID:23141184   PMID:23196056   PMID:23259998   PMID:23316072  
PMID:23504324   PMID:23528710   PMID:23618859   PMID:23623839   PMID:23658023   PMID:23667531   PMID:23744557   PMID:23798676   PMID:24009013   PMID:24037310   PMID:24084383   PMID:24317814  
PMID:24430538   PMID:24449575   PMID:24485923   PMID:24517278   PMID:24595148   PMID:24606730   PMID:24711643   PMID:24767859   PMID:24780075   PMID:24895995   PMID:24909560   PMID:24973403  
PMID:25048722   PMID:25059387   PMID:25061178   PMID:25104090   PMID:25135600   PMID:25326651   PMID:25329584   PMID:25421497   PMID:25501701   PMID:25536346   PMID:25620088   PMID:25709087  
PMID:25728492   PMID:25773758   PMID:25822023   PMID:25854342   PMID:25974135   PMID:25980494   PMID:26028023   PMID:26201842   PMID:26203933   PMID:26424659   PMID:26459773   PMID:26496610  
PMID:26498181   PMID:26630293   PMID:26744771   PMID:26760575   PMID:26884454   PMID:26923924   PMID:27105510   PMID:27113745   PMID:27286449   PMID:27456070   PMID:27465842   PMID:27509825  
PMID:27583562   PMID:27585710   PMID:27604902   PMID:27633176   PMID:27644084   PMID:27653023   PMID:27665942   PMID:27666419   PMID:27684187   PMID:27705906   PMID:27725691   PMID:27743169  
PMID:27856305   PMID:27889647   PMID:27911269   PMID:28035364   PMID:28116298   PMID:28263504   PMID:28322825   PMID:28327460   PMID:28341837   PMID:28476813   PMID:28514442   PMID:28548552  
PMID:28602508   PMID:28638955   PMID:28647210   PMID:28750181   PMID:28785028   PMID:28824319   PMID:29055676   PMID:29286082   PMID:29287201   PMID:29345157   PMID:29414775   PMID:29510193  
PMID:30045012   PMID:30142763   PMID:30142822   PMID:30178386   PMID:30361094   PMID:30376856   PMID:30471916   PMID:30535449   PMID:30642298   PMID:30685604   PMID:30787177   PMID:31073040  
PMID:31111478   PMID:31113467   PMID:31118064   PMID:31262999   PMID:31281518   PMID:31317175   PMID:31429823   PMID:31478661   PMID:31586073   PMID:31606201   PMID:31672144   PMID:31766991  
PMID:32081971   PMID:32296183   PMID:32740993  


Genomics

Comparative Map Data
CCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl185,580,761 - 85,584,589 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl185,580,761 - 85,583,950 (+)EnsemblGRCh38hg38GRCh38
GRCh38185,580,761 - 85,583,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37186,046,444 - 86,049,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,819,048 - 85,821,978 (+)NCBINCBI36hg18NCBI36
Build 34185,758,480 - 85,761,410NCBI
Celera184,290,551 - 84,293,757 (+)NCBI
Cytogenetic Map1p22.3NCBI
HuRef184,157,232 - 84,160,438 (+)NCBIHuRef
CHM1_1186,161,864 - 86,165,070 (+)NCBICHM1_1
Ccn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393145,352,726 - 145,355,740 (-)NCBIGRCm39mm39
GRCm383145,646,971 - 145,649,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3145,646,976 - 145,649,981 (-)EnsemblGRCm38mm10GRCm38
MGSCv373145,309,935 - 145,312,949 (-)NCBIGRCm37mm9NCBIm37
MGSCv363145,584,362 - 145,587,367 (-)NCBImm8
Celera3152,099,713 - 152,102,726 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map370.18NCBI
Ccn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02251,529,354 - 251,532,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,529,354 - 251,532,312 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,055,954 - 270,058,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42243,824,303 - 243,827,262 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12243,811,042 - 243,814,002 (-)NCBI
Celera2226,551,241 - 226,554,210 (-)NCBICelera
Cytogenetic Map2q44NCBI
Ccn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554238,413,725 - 8,419,166 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554238,416,498 - 8,419,029 (-)NCBIChiLan1.0ChiLan1.0
CCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1186,994,296 - 86,997,147 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl186,994,296 - 86,997,147 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01118,138,739 - 118,141,681 (+)NCBIMhudiblu_PPA_v0panPan3
CCN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl662,443,675 - 62,445,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1662,443,285 - 62,446,246 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ccn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936608152,174 - 155,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4130,392,404 - 130,395,150 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14130,392,404 - 130,395,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24142,924,666 - 142,927,450 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12047,783,270 - 47,786,216 (-)NCBI
ChlSab1.1 Ensembl2047,783,935 - 47,785,997 (-)Ensembl
Ccn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474211,882,815 - 11,885,686 (-)NCBI

Position Markers
D1S3544  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37186,049,149 - 86,049,298UniSTSGRCh37
Build 36185,821,737 - 85,821,886RGDNCBI36
Celera184,293,256 - 84,293,405RGD
Cytogenetic Map1p22.3UniSTS
HuRef184,159,937 - 84,160,086UniSTS
TNG Radiation Hybrid Map148781.0UniSTS
Stanford-G3 RH Map14205.0UniSTS
GeneMap99-GB4 RH Map1241.06UniSTS
NCBI RH Map1566.2UniSTS
GeneMap99-G3 RH Map14161.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR30Ahsa-miR-30a-3pTarbaseexternal_infoWesternblitPOSITIVE
MIR205hsa-miR-205-5pOncomiRDBexternal_infoNANA23056551
MIR205hsa-miR-205-5pMirtarbaseexternal_infoWestern blotFunctional MTI23056551
MIR155hsa-miR-155-3pMirecordsexternal_info{changed}NA20452491
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20452491

Predicted Target Of
Summary Value
Count of predictions:630
Count of miRNA genes:464
Interacting mature miRNAs:516
Transcripts:ENST00000451137, ENST00000480413
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 126 543 168 3 18 5 600 45 126 23 112 343 1 433 347
Medium 2230 1658 1497 591 541 435 3707 2052 2436 371 1312 1203 166 771 2409 3
Low 73 555 56 28 617 25 47 96 1149 24 33 60 7 1 32 3
Below cutoff 8 225 1 563 2 2 7 1 2 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF003114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF003594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF031385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF307860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY443495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP387218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA764894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z50168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z97068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z98053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z98054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000451137   ⟹   ENSP00000398736
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl185,580,761 - 85,583,950 (+)Ensembl
RefSeq Acc Id: ENST00000480413
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl185,581,200 - 85,582,099 (+)Ensembl
RefSeq Acc Id: ENST00000674743
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl185,580,922 - 85,583,930 (+)Ensembl
RefSeq Acc Id: ENST00000674818
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl185,580,915 - 85,584,589 (+)Ensembl
RefSeq Acc Id: ENST00000675083   ⟹   ENSP00000502303
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl185,581,463 - 85,583,930 (+)Ensembl
RefSeq Acc Id: ENST00000676007
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl185,580,900 - 85,583,653 (+)Ensembl
RefSeq Acc Id: NM_001554   ⟹   NP_001545
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38185,580,761 - 85,583,950 (+)NCBI
GRCh37186,046,444 - 86,049,650 (+)ENTREZGENE
Build 36185,819,048 - 85,821,978 (+)NCBI Archive
HuRef184,157,232 - 84,160,438 (+)ENTREZGENE
CHM1_1186,161,864 - 86,165,070 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001545   ⟸   NM_001554
- Peptide Label: precursor
- UniProtKB: O00622 (UniProtKB/Swiss-Prot),   Q6FI18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000398736   ⟸   ENST00000451137
RefSeq Acc Id: ENSP00000502303   ⟸   ENST00000675083
Protein Domains
CTCK   IGFBP N-terminal   TSP type-1   VWFC

Promoters
RGD ID:6856070
Promoter ID:EPDNEW_H1199
Type:initiation region
Name:CYR61_1
Description:cysteine rich angiogenic inducer 61
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38185,580,761 - 85,580,821EPDNEW
RGD ID:6784994
Promoter ID:HG_KWN:3485
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_001554,   OTTHUMT00000029188,   UC001DLG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36185,819,046 - 85,819,547 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|See cases [RCV000051825] Chr1:72661709..107456880 [GRCh38]
Chr1:73127392..107999502 [GRCh37]
Chr1:72899980..107801025 [NCBI36]
Chr1:1p31.1-13.3
pathogenic
GRCh38/hg38 1p31.1-21.1(chr1:83457325-104273917)x3 copy number gain See cases [RCV000135654] Chr1:83457325..104273917 [GRCh38]
Chr1:83923008..104816539 [GRCh37]
Chr1:83695596..104618062 [NCBI36]
Chr1:1p31.1-21.1
pathogenic
GRCh38/hg38 1p32.1-22.3(chr1:58819605-86098611)x1 copy number loss See cases [RCV000136913] Chr1:58819605..86098611 [GRCh38]
Chr1:59285277..86564294 [GRCh37]
Chr1:59057865..86336882 [NCBI36]
Chr1:1p32.1-22.3
pathogenic
GRCh38/hg38 1p31.1-22.2(chr1:76419302-88628464)x1 copy number loss See cases [RCV000138957] Chr1:76419302..88628464 [GRCh38]
Chr1:76884987..89094147 [GRCh37]
Chr1:76657575..88866735 [NCBI36]
Chr1:1p31.1-22.2
pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p31.1-22.1(chr1:72044544-92505091)x1 copy number loss See cases [RCV000510161] Chr1:72044544..92505091 [GRCh37]
Chr1:1p31.1-22.1
pathogenic
GRCh37/hg19 1p22.3(chr1:85761564-86703902)x1 copy number loss See cases [RCV000511645] Chr1:85761564..86703902 [GRCh37]
Chr1:1p22.3
uncertain significance
GRCh37/hg19 1p22.3(chr1:86027015-86606921)x3 copy number gain See cases [RCV000511358] Chr1:86027015..86606921 [GRCh37]
Chr1:1p22.3
uncertain significance
GRCh37/hg19 1p31.3-22.3(chr1:64321264-88153669)x1 copy number loss See cases [RCV000511392] Chr1:64321264..88153669 [GRCh37]
Chr1:1p31.3-22.3
pathogenic
GRCh37/hg19 1p22.3(chr1:86006704-86727751)x3 copy number gain See cases [RCV000511205] Chr1:86006704..86727751 [GRCh37]
Chr1:1p22.3
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p22.3(chr1:85765619-86697145)x1 copy number loss not provided [RCV000749056] Chr1:85765619..86697145 [GRCh37]
Chr1:1p22.3
benign
NM_001554.5(CCN1):c.947C>G (p.Ser316Cys) single nucleotide variant not provided [RCV000884967] Chr1:85582843 [GRCh38]
Chr1:86048526 [GRCh37]
Chr1:1p22.3
likely benign
NM_001554.5(CCN1):c.900C>T (p.Tyr300=) single nucleotide variant not provided [RCV000882494] Chr1:85582796 [GRCh38]
Chr1:86048479 [GRCh37]
Chr1:1p22.3
benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
Single allele deletion not provided [RCV000844927] Chr1:66085524..88429789 [GRCh37]
Chr1:1p31.3-22.2
not provided
GRCh37/hg19 1p31.3-22.3(chr1:67851233-86101340)x1 copy number loss not provided [RCV000846441] Chr1:67851233..86101340 [GRCh37]
Chr1:1p31.3-22.3
pathogenic
GRCh37/hg19 1p31.1-22.2(chr1:80804502-89490384)x3 copy number gain not provided [RCV001259073] Chr1:80804502..89490384 [GRCh37]
Chr1:1p31.1-22.2
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2654 AgrOrtholog
COSMIC CCN1 COSMIC
Ensembl Genes ENSG00000142871 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000398736 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000502303 UniProtKB/TrEMBL
Ensembl Transcript ENST00000451137 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000675083 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000142871 GTEx
HGNC ID HGNC:2654 ENTREZGENE
Human Proteome Map CCN1 Human Proteome Map
InterPro Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3491 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3491 ENTREZGENE
OMIM 602369 OMIM
Pfam Cys_knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27126 PharmGKB
PIRSF IGFBP_rP_CNN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6Q8PGQ1_HUMAN UniProtKB/TrEMBL
  CYR61_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FI18 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3DT19 UniProtKB/TrEMBL
  O14934 UniProtKB/Swiss-Prot
  O43775 UniProtKB/Swiss-Prot
  Q9BZL7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-16 CCN1  cellular communication network factor 1  CYR61  cysteine rich angiogenic inducer 61  Symbol and/or name change 5135510 APPROVED
2016-01-19 CYR61  cysteine rich angiogenic inducer 61    cysteine-rich, angiogenic inducer, 61  Symbol and/or name change 5135510 APPROVED