FGA (fibrinogen alpha chain) - Rat Genome Database

Name: FGA
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: FGA (fibrinogen alpha chain) Homo sapiens

Analyze

Symbol:

FGA

Name:

fibrinogen alpha chain

RGD ID:

737209

HGNC Page

HGNC

Description:

Exhibits structural molecule activity. Contributes to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of secretion by cell. Localizes to external side of plasma membrane; fibrinogen complex; and platelet alpha granule. Implicated in congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Biomarker of Crohn's disease; acute lymphoblastic leukemia; keratoconus; and type 2 diabetes mellitus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

Fib2; fibrinogen, A alpha polypeptide; fibrinogen, alpha polypeptide; MGC119422; MGC119423; MGC119425

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Fga (fibrinogen alpha chain)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Fga (fibrinogen alpha chain)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Fga (fibrinogen alpha chain)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	FGA (fibrinogen alpha chain)	NCBI	Ortholog
Canis lupus familiaris (dog):	FGA (fibrinogen alpha chain)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fga (fibrinogen alpha chain)	NCBI	Ortholog
Sus scrofa (pig):	FGA (fibrinogen alpha chain)	HGNC	EggNOG, NCBI, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (African green monkey):	FGA (fibrinogen alpha chain)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Fga (fibrinogen alpha chain)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Fga (fibrinogen alpha chain)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Fga (fibrinogen alpha chain)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	fga (fibrinogen alpha chain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|TreeFam\|ZFIN)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	154,583,128 - 154,590,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	154,583,126 - 154,590,742 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	155,504,278 - 155,511,894 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	155,723,730 - 155,731,347 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	155,864,033 - 155,869,470	NCBI
Celera	4	152,835,246 - 152,842,862 (-)	NCBI
Cytogenetic Map	4	q31.3	NCBI
HuRef	4	151,244,861 - 151,252,473 (-)	NCBI		HuRef
CHM1_1	4	155,482,199 - 155,489,839 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Acute Liver Failure (ISO)

Acute Lung Injury (ISO)

acute lymphoblastic leukemia (IEP)

acute pancreatitis (ISO)

asthma (ISO)

brain ischemia (ISO)

Burns (ISO)

Cerebral Small Vessel Diseases (IAGP)

Chemical and Drug Induced Liver Injury (EXP)

cholestasis (EXP)

congenital afibrinogenemia (EXP,IAGP)

Congenital Dysfibrinogenemia (IAGP)

Congenital Hypodysfibrinogenemia (IAGP)

Crohn's disease (IEP)

disseminated intravascular coagulation (ISO)

Endotoxemia (ISO)

Experimental Diabetes Mellitus (ISO)

Familial Amyloidosis (EXP,IAGP)

familial visceral amyloidosis (IAGP)

hemorrhagic disease (IAGP)

keratoconus (IEP)

kidney disease (EXP)

Kidney Reperfusion Injury (ISO)

Liver Reperfusion Injury (ISO)

Mouth Neoplasms (EXP)

osteoporosis (EXP)

pancreatitis (ISO)

pulmonary embolism (EXP,ISO)

pulmonary emphysema (ISO)

Seasonal Allergic Rhinitis (IDA)

Sepsis (ISO)

Stroke (EXP)

thrombocytopenia (IAGP,ISO)

thrombophilia (EXP,IAGP)

thrombosis (EXP)

type 2 diabetes mellitus (IEP)

Venous Thromboembolism (EXP,IAGP)

Venous Thrombosis (IAGP,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP,ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3H-1,2-dithiole-3-thione (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acetylsalicylic acid (EXP)

ADP (EXP)

aflatoxin B1 (EXP)

ammonium chloride (ISO)

arsane (EXP)

arsenic atom (EXP)

Azaspiracid (EXP)

azathioprine (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (EXP)

benzo[b]fluoranthene (EXP)

bexarotene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (ISO)

buta-1,3-diene (ISO)

butanal (EXP)

carbon nanotube (ISO)

chloroform (ISO)

chlorpromazine (EXP)

choline (ISO)

cisplatin (EXP)

clofibric acid (ISO)

cobalt dichloride (EXP,ISO)

copper(II) sulfate (EXP)

cycloheximide (ISO)

cyclosporin A (EXP,ISO)

cylindrospermopsin (EXP,ISO)

dabigatran (ISO)

decabromodiphenyl ether (ISO)

dibenz[a,h]anthracene (EXP)

dicrotophos (EXP)

dienogest (EXP)

diisopropyl fluorophosphate (ISO)

doxorubicin (ISO)

endosulfan (ISO)

erythromycin estolate (ISO)

fenofibrate (ISO)

flutamide (ISO)

folic acid (EXP,ISO)

furan (ISO)

genistein (ISO)

gestodene (EXP)

glafenine (ISO)

GW 4064 (ISO)

heparin (EXP)

hydrazine (ISO)

L-methionine (ISO)

lead diacetate (ISO)

levonorgestrel (EXP)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methimazole (ISO)

methotrexate (ISO)

methylmercury chloride (EXP)

morphine (ISO)

N-nitrosodiethylamine (ISO)

Natamycin (ISO)

nefazodone (ISO)

nickel atom (EXP)

nimesulide (ISO)

norethisterone (EXP)

norgestimate (EXP)

nystatin (ISO)

O-methyleugenol (EXP)

paracetamol (EXP,ISO)

pentanal (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (EXP)

propanal (EXP)

quercetin (EXP)

quinidine (ISO)

rotenone (ISO)

silicon dioxide (EXP,ISO)

silver atom (EXP)

silver(0) (EXP)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (ISO)

sulfasalazine (ISO)

tacrolimus hydrate (ISO)

tetrachloromethane (ISO)

tetracycline (ISO)

theophylline (ISO)

tolcapone (ISO)

tremolite asbestos (ISO)

tributylstannane (ISO)

Triptolide (ISO)

trovafloxacin (ISO)

urethane (EXP)

valproic acid (EXP)

vancomycin (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute-phase response (ISO)

adaptive immune response (IEA)

amyloid fibril formation (TAS)

blood coagulation (ISO,TAS)

blood coagulation, common pathway (IBA,IMP)

blood coagulation, fibrin clot formation (IDA)

cell-matrix adhesion (IDA)

cellular protein metabolic process (TAS)

cellular protein-containing complex assembly (IDA)

cellular response to granulocyte colony-stimulating factor (ISO)

cellular response to interleukin-6 (ISO)

cellular response to organic cyclic compound (ISO)

envenomation resulting in modulation of blood coagulation in other organism (ISO)

extracellular matrix organization (TAS)

fibrinolysis (IBA,IDA)

induction of bacterial agglutination (IDA)

innate immune response (IEA)

liver regeneration (ISO)

negative regulation of blood coagulation, common pathway (TAS)

negative regulation of endothelial cell apoptotic process (IBA,IDA)

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (IBA,IDA)

plasminogen activation (IDA)

platelet activation (IEA)

platelet aggregation (HMP,IBA,IDA)

platelet degranulation (TAS)

positive regulation of ERK1 and ERK2 cascade (IBA,IDA)

positive regulation of exocytosis (IDA)

positive regulation of heterotypic cell-cell adhesion (IBA,IDA)

positive regulation of peptide hormone secretion (IBA,IDA)

positive regulation of protein secretion (IDA)

positive regulation of smooth muscle cell migration (ISO)

positive regulation of substrate adhesion-dependent cell spreading (NAS)

positive regulation of vasoconstriction (IDA)

post-translational protein modification (TAS)

protein polymerization (IBA,IDA,IEA)

protein-containing complex assembly (IMP)

response to calcium ion (IDA)

response to cycloheximide (ISO)

response to estradiol (ISO)

response to genistein (ISO)

response to growth hormone (ISO)

response to insulin (ISO)

response to morphine (ISO)

response to thyroid hormone (ISO)

response to toxic substance (ISO)

response to X-ray (ISO)

toll-like receptor signaling pathway (TAS)

Cellular Component

blood microparticle (HDA,ISO)

cell cortex (IEA)

cell surface (IDA)

collagen-containing extracellular matrix (HDA)

cytoplasm (ISO)

endoplasmic reticulum lumen (TAS)

external side of plasma membrane (IDA)

extracellular exosome (HDA)

extracellular region (NAS,TAS)

extracellular space (IDA,ISO)

extracellular vesicle (HDA)

fibrinogen complex (IBA,IDA,IEA)

plasma membrane (TAS)

platelet alpha granule (IDA)

platelet alpha granule lumen (TAS)

rough endoplasmic reticulum (ISO)

synapse (IEA,ISO)

Molecular Function

cell adhesion molecule binding (IDA)

extracellular matrix structural constituent (HDA,RCA)

metal ion binding (IEA)

protein binding (IPI)

signaling receptor binding (IDA,IEA)

structural molecule activity (IDA,IMP)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (EXP)

alteplase pharmacodynamics pathway (EXP)

aminocaproic acid pharmacodynamics pathway (EXP)

anistreplase pharmacodynamics pathway (EXP)

aprotinin pharmacodynamics pathway (EXP)

argatroban pharmacodynamics pathway (EXP)

bivalirudin pharmacodynamics pathway (EXP)

coagulation cascade pathway (IEA,TAS)

complement system pathway (IEA)

dicoumarol pharmacodynamics pathway (EXP)

enoxaparin pharmacodynamics pathway (EXP)

ephrin - ephrin receptor bidirectional signaling axis (EXP)

fibrinolysis pathway (TAS)

fondaparinux pharmacodynamics pathway (EXP)

heparin pharmacodynamics pathway (EXP)

phenindione pharmacodynamics pathway (EXP)

reteplase pharmacodynamics pathway (EXP)

tranexamic acid pharmacodynamics pathway (EXP)

warfarin pharmacodynamics pathway (EXP)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Abnormal bleeding (IAGP)

Autosomal dominant inheritance (IAGP)

Autosomal recessive inheritance (IAGP)

Cerebral hemorrhage (IAGP)

Cholestasis (IAGP)

Dysfibrinogenemia (IAGP)

Edema (IAGP)

Epistaxis (IAGP)

Gastrointestinal hemorrhage (IAGP)

Generalized amyloid deposition (IAGP)

Gingival bleeding (IAGP)

Hematuria (IAGP)

Hepatomegaly (IAGP)

Hypertension (IAGP)

Hypofibrinogenemia (IAGP)

Joint swelling (IAGP)

Menometrorrhagia (IAGP)

Nephropathy (IAGP)

Nephrotic syndrome (IAGP)

Prolonged partial thromboplastin time (IAGP)

Proteinuria (IAGP)

Skin rash (IAGP)

Splenic rupture (IAGP)

Splenomegaly (IAGP)

Spontaneous abortion (IAGP)

Thrombocytopenia (IAGP)

Venous thrombosis (IAGP)

References

References - curated


1.	Ashour TH Adv Hematol. 2014;2014:705290. doi: 10.1155/2014/705290. Epub 2014 Apr 1.
2.	Bai J, etal., Proteome Sci. 2014 Sep 16;12(1):49. doi: 10.1186/s12953-014-0049-y. eCollection 2014.
3.	Balasubramanian SA, etal., Mol Vis. 2013 Oct 30;19:2124-34. eCollection 2013.
4.	Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
5.	Benson MD, etal., Nat Genet. 1993 Mar;3(3):252-5.
6.	Carter AM, etal., Blood. 2000 Aug 1;96(3):1177-9.
7.	Chen X, etal., J Proteome Res. 2010 Feb 5;9(2):885-96.
8.	Choi SA, etal., Mol Biol Rep. 2013 Feb;40(2):1753-65. doi: 10.1007/s11033-012-2229-0. Epub 2012 Oct 20.
9.	Dong F, etal., Evid Based Complement Alternat Med. 2014;2014:726740. doi: 10.1155/2014/726740. Epub 2014 Jan 2.
10.	Feng J, etal., PLoS One. 2010 Oct 6;5(10):e13201. doi: 10.1371/journal.pone.0013201.
11.	Iba T and Takayama T, Shock. 2009 Nov;32(5):530-4. doi: 10.1097/SHK.0b013e3181a2e279.
12.	Jiang X, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):170-2.
13.	Jiao J, etal., Shock. 2014 Jul;42(1):75-81. doi: 10.1097/SHK.0000000000000173.
14.	Jin Y, etal., Pulm Pharmacol Ther. 2013 Dec;26(6):661-5. doi: 10.1016/j.pupt.2013.03.013. Epub 2013 Mar 26.
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19.	Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
20.	Lotta LA, etal., BMC Med Genomics. 2012 Feb 21;5(1):7.
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24.	Nicholson NS, etal., J Pharmacol Exp Ther. 1991 Mar;256(3):876-82.
25.	OMIM Disease Annotation Pipeline
26.	Online Mendelian Inheritance in Man, OMIM (TM).
27.	Pipeline to import KEGG annotations from KEGG into RGD
28.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29.	Pipeline to import SMPDB annotations from SMPDB into RGD
30.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31.	RGD automated import pipeline for gene-chemical interactions
32.	RGD automated import pipeline for human HPO-to-gene-to-disease annotations
33.	Thukral SK, etal., Toxicol Pathol. 2005;33(3):343-55.
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Additional References at PubMed

PMID:518845	PMID:518846	PMID:632262	PMID:936108	PMID:1391954	PMID:1457396	PMID:1560020	PMID:1587268	PMID:1634621	PMID:1675636	PMID:1680863	PMID:1912564
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PMID:23056168	PMID:23061815	PMID:23224113	PMID:23238100	PMID:23303819	PMID:23314748	PMID:23376485	PMID:23382103	PMID:23533145	PMID:23551149	PMID:23612884	PMID:23639427
PMID:23725126	PMID:23750785	PMID:23852822	PMID:23877568	PMID:23894515	PMID:23958299	PMID:23969696	PMID:24040290	PMID:24041635	PMID:24048413	PMID:24122271	PMID:24192574
PMID:24337577	PMID:24367264	PMID:24627488	PMID:24769233	PMID:24803720	PMID:24821635	PMID:25037231	PMID:25163824	PMID:25182841	PMID:25241761	PMID:25275549	PMID:25280629
PMID:25347092	PMID:25393591	PMID:25555432	PMID:25569856	PMID:25896761	PMID:25914268	PMID:25923092	PMID:25981141	PMID:26083984	PMID:26091039	PMID:26139837	PMID:26186194
PMID:26228839	PMID:26256740	PMID:26354767	PMID:26496610	PMID:26540126	PMID:26581183	PMID:26871637	PMID:26951791	PMID:27044366	PMID:27099386	PMID:27105953	PMID:27164460
PMID:27221710	PMID:27231021	PMID:27266621	PMID:27519977	PMID:27555433	PMID:27738342	PMID:27760719	PMID:28119309	PMID:28192448	PMID:28203040	PMID:28219450	PMID:28269756
PMID:28344315	PMID:28350862	PMID:28359658	PMID:28425010	PMID:28514442	PMID:28675934	PMID:28750085	PMID:28816342	PMID:28851981	PMID:29016666	PMID:29021578	PMID:29089309
PMID:29240685	PMID:29509190	PMID:29540212	PMID:29662311	PMID:29748775	PMID:29791485	PMID:29874984	PMID:29932420	PMID:30039577	PMID:30106150	PMID:30838756	PMID:31041195
PMID:31180492	PMID:31253657	PMID:31260799	PMID:31295712	PMID:31343282	PMID:31443619	PMID:31511434	PMID:31515786	PMID:31625351	PMID:31713292	PMID:31725541	PMID:31740226
PMID:31992359	PMID:32126779	PMID:32286477	PMID:32296183	PMID:32638959	PMID:32877691	PMID:33317138	PMID:33472402

Genomics

Comparative Map Data

FGA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	154,583,128 - 154,590,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	154,583,126 - 154,590,742 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	155,504,278 - 155,511,894 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	155,723,730 - 155,731,347 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	155,864,033 - 155,869,470	NCBI
Celera	4	152,835,246 - 152,842,862 (-)	NCBI
Cytogenetic Map	4	q31.3	NCBI
HuRef	4	151,244,861 - 151,252,473 (-)	NCBI		HuRef
CHM1_1	4	155,482,199 - 155,489,839 (-)	NCBI		CHM1_1

Fga
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	82,933,460 - 82,940,934 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	3	82,933,383 - 82,940,934 (+)	Ensembl
GRCm38	3	83,026,153 - 83,033,627 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	83,026,076 - 83,033,627 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	82,830,075 - 82,837,549 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	83,112,081 - 83,118,197 (+)	NCBI			mm8
Celera	3	83,030,275 - 83,037,743 (+)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI
cM Map	3	36.96	NCBI

Fga
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	168,365,364 - 168,381,533 (+)	NCBI
Rnor_6.0 Ensembl	2	182,006,242 - 182,013,763 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	181,997,562 - 182,013,726 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	201,412,182 - 201,428,346 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	174,737,640 - 174,753,598 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	174,694,725 - 174,703,904 (+)	NCBI
Celera	2	162,392,064 - 162,408,023 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Fga
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	8,806,650 - 8,816,791 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955471	8,806,964 - 8,814,671 (+)	NCBI	ChiLan1.0	ChiLan1.0

FGA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	158,767,782 - 158,775,414 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	4	146,949,680 - 146,957,291 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

FGA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	52,238,305 - 52,247,017 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	52,236,198 - 52,246,975 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	52,584,628 - 52,591,483 (-)	NCBI
ROS_Cfam_1.0	15	52,924,743 - 52,933,990 (-)	NCBI
UMICH_Zoey_3.1	15	52,179,682 - 52,188,900 (-)	NCBI
UNSW_CanFamBas_1.0	15	52,283,995 - 52,293,478 (-)	NCBI
UU_Cfam_GSD_1.0	15	52,601,176 - 52,608,068 (-)	NCBI

Fga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	38,217,093 - 38,224,715 (+)	NCBI
SpeTri2.0	NW_004936576	1,322,406 - 1,329,743 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	74,574,882 - 74,584,202 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	74,574,870 - 74,584,202 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	78,935,842 - 78,938,718 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FGA
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	101,127,554 - 101,134,881 (-)	NCBI
ChlSab1.1 Ensembl	7	101,125,791 - 101,134,405 (-)	Ensembl

Fga
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624858	5,848,817 - 5,856,448 (+)	NCBI

Position Markers

D4S3286

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,504,351 - 155,504,480	UniSTS	GRCh37
Build 36	4	155,723,801 - 155,723,930	RGD	NCBI36
Celera	4	152,835,317 - 152,835,446	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,244,932 - 151,245,061	UniSTS
TNG Radiation Hybrid Map	4	93091.0	UniSTS
GeneMap99-G3 RH Map	4	8495.0	UniSTS

STS-H58121

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,092 - 155,507,239	UniSTS	GRCh37
Build 36	4	155,726,542 - 155,726,689	RGD	NCBI36
Celera	4	152,838,058 - 152,838,205	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,673 - 151,247,820	UniSTS
TNG Radiation Hybrid Map	4	93091.0	UniSTS
GeneMap99-GB4 RH Map	4	636.0	UniSTS
NCBI RH Map	4	1584.6	UniSTS

SHGC-59324

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,212 - 155,507,339	UniSTS	GRCh37
Build 36	4	155,726,662 - 155,726,789	RGD	NCBI36
Celera	4	152,838,178 - 152,838,305	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,793 - 151,247,920	UniSTS
GeneMap99-GB4 RH Map	4	635.41	UniSTS
Whitehead-RH Map	4	685.9	UniSTS
NCBI RH Map	4	1584.6	UniSTS

SHGC-34795

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,150 - 155,507,276	UniSTS	GRCh37
Build 36	4	155,726,600 - 155,726,726	RGD	NCBI36
Celera	4	152,838,116 - 152,838,242	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,731 - 151,247,857	UniSTS
Stanford-G3 RH Map	4	8523.0	UniSTS
GeneMap99-GB4 RH Map	4	632.82	UniSTS
Whitehead-RH Map	4	689.7	UniSTS
NCBI RH Map	4	1584.4	UniSTS
GeneMap99-G3 RH Map	4	8448.0	UniSTS

GDB:187393

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,786 - 155,507,984	UniSTS	GRCh37
Build 36	4	155,727,236 - 155,727,434	RGD	NCBI36
Celera	4	152,838,752 - 152,838,950	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,248,367 - 151,248,565	UniSTS

GDB:215015

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,508,767 - 155,509,040	UniSTS	GRCh37
Build 36	4	155,728,217 - 155,728,490	RGD	NCBI36
Celera	4	152,839,733 - 152,840,005	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,249,348 - 151,249,617	UniSTS

GDB:374018

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,505,122 - 155,506,052	UniSTS	GRCh37
Build 36	4	155,724,572 - 155,725,502	RGD	NCBI36
Celera	4	152,836,088 - 152,837,018	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,245,703 - 151,246,633	UniSTS

D4S2882

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,504,531 - 155,504,690	UniSTS	GRCh37
Build 36	4	155,723,981 - 155,724,140	RGD	NCBI36
Celera	4	152,835,497 - 152,835,656	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,245,112 - 151,245,271	UniSTS
Whitehead-YAC Contig Map	4		UniSTS

SHGC-59770

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,506,493 - 155,506,676	UniSTS	GRCh37
Build 36	4	155,725,943 - 155,726,126	RGD	NCBI36
Celera	4	152,837,459 - 152,837,642	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,074 - 151,247,257	UniSTS
GeneMap99-GB4 RH Map	4	634.17	UniSTS
NCBI RH Map	4	1613.3	UniSTS

RH18276

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,258 - 155,507,454	UniSTS	GRCh37
Build 36	4	155,726,708 - 155,726,904	RGD	NCBI36
Celera	4	152,838,224 - 152,838,420	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,839 - 151,248,035	UniSTS
GeneMap99-GB4 RH Map	4	635.9	UniSTS
NCBI RH Map	4	1584.6	UniSTS

STS-H72060

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,505,242 - 155,505,383	UniSTS	GRCh37
Build 36	4	155,724,692 - 155,724,833	RGD	NCBI36
Celera	4	152,836,208 - 152,836,349	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,245,823 - 151,245,964	UniSTS
TNG Radiation Hybrid Map	4	93091.0	UniSTS
GeneMap99-GB4 RH Map	4	636.0	UniSTS
NCBI RH Map	4	1584.6	UniSTS

SHGC-32984

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,815 - 155,507,940	UniSTS	GRCh37
Build 36	4	155,727,265 - 155,727,390	RGD	NCBI36
Celera	4	152,838,781 - 152,838,906	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,248,396 - 151,248,521	UniSTS
TNG Radiation Hybrid Map	4	93091.0	UniSTS
GeneMap99-GB4 RH Map	4	636.0	UniSTS
Whitehead-RH Map	4	685.9	UniSTS
NCBI RH Map	4	1584.6	UniSTS
GeneMap99-G3 RH Map	4	8482.0	UniSTS

D4S3155

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,506,414 - 155,506,638	UniSTS	GRCh37
Build 36	4	155,725,864 - 155,726,088	RGD	NCBI36
Celera	4	152,837,380 - 152,837,604	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,246,995 - 151,247,219	UniSTS
TNG Radiation Hybrid Map	4	93091.0	UniSTS
Whitehead-YAC Contig Map	4		UniSTS
GeneMap99-G3 RH Map	4	8495.0	UniSTS

SHGC-50337

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,506,465 - 155,506,745	UniSTS	GRCh37
Build 36	4	155,725,915 - 155,726,195	RGD	NCBI36
Celera	4	152,837,431 - 152,837,711	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,046 - 151,247,326	UniSTS
TNG Radiation Hybrid Map	4	93131.0	UniSTS

FGA

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,508,848 - 155,509,043	UniSTS	GRCh37
Build 36	4	155,728,298 - 155,728,493	RGD	NCBI36
Celera	4	152,839,814 - 152,840,008	RGD
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,249,429 - 151,249,620	UniSTS

FGA_3978

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,504,251 - 155,505,172	UniSTS	GRCh37
Build 36	4	155,723,701 - 155,724,622	RGD	NCBI36
Celera	4	152,835,217 - 152,836,138	RGD

GDB:633003

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	155,507,255 - 155,507,838	UniSTS	GRCh37
Celera	4	152,838,221 - 152,838,804	UniSTS
Cytogenetic Map	4	q28	UniSTS
HuRef	4	151,247,836 - 151,248,419	UniSTS

G33492

Human Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	4	q28	UniSTS

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR409	hsa-miR-409-3p	Mirtarbase	external_info	ELISA//Flow//Luciferase reporter assay	Non-Functional MTI	20570858
MIR29B1	hsa-miR-29b-3p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	20570858
MIR29A	hsa-miR-29a-3p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	20570858
MIR144	hsa-miR-144-3p	Mirtarbase	external_info	Luciferase reporter assay	Non-Functional MTI	20570858
MIR29B2	hsa-miR-29b-3p	Mirtarbase	external_info	Luciferase reporter assay	Functional MTI	20570858

Predicted Target Of

	Summary Value
Count of predictions:	558
Count of miRNA genes:	407
Interacting mature miRNAs:	434
Transcripts:	ENST00000302053, ENST00000403106
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

407

Medium

214

131

Low

572

671

388

428

710

372

455

127

665

593

230

451

Below cutoff

973

1281

546

529

1610

935

1605

110

375

447

530

1043

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_008832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_000508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_021871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB087996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC107385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF090936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF229198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF361104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK290559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL531808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL579998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG565064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ064506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX494953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB122305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD608675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CN393696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J00127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J00128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JB978078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	K02272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU178062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU178063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU178064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU178065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M26878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M64982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S82092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000403106 ⟹ ENSP00000385981

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	154,585,275 - 154,590,742 (-)	Ensembl

RefSeq Acc Id:

ENST00000622532 ⟹ ENSP00000478487

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	154,585,281 - 154,590,744 (-)	Ensembl

RefSeq Acc Id:

ENST00000651975 ⟹ ENSP00000498441

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	154,583,128 - 154,590,745 (-)	Ensembl

RefSeq Acc Id:

NM_000508 ⟹ NP_000499

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	154,583,126 - 154,590,742 (-)	NCBI
GRCh37	4	155,504,280 - 155,511,897 (-)	ENTREZGENE
Build 36	4	155,723,730 - 155,731,347 (-)	NCBI Archive
HuRef	4	151,244,861 - 151,252,473 (-)	ENTREZGENE
CHM1_1	4	155,482,199 - 155,489,839 (-)	NCBI

Sequence:

show sequence

AGGATGGGAACTAGGAGTGGCAGCAATCCTTTCTTTCAGCTGGAGTGCTCCTCAGGAGCCAGCC
CCACCCTTAGAAAAGATGTTTTCCATGAGGATCGTCTGCCTGGTCCTAAGTGTGGTGGGCACAG
CATGGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAG
GGTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGAC
TGGAACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATT
TTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAACAATAAGGATTC
TCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGT
GATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAG
TCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAATGTTAGAGCTCAGTTGGTTGATAT
GAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCT
TTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTG
CCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAATGAAACCAGTTCC
AGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTA
ACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAG
GCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAG
CTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACT
GGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTG
GGAGCTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGG
AACCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTA
TCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTG
GGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCC
AGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGG
ACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCG
TTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGA
AGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGAT
GGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGGAAAAACAT
TCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGA
ATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCT
TCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAG
ACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGA
AGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGACTGTGATGATGTC
CTCCAAACACATCCTTCAGGTACCCAAAGTGGCATTTTCAATATCAAGCTACCGGGATCCAGTA
AGATTTTTTCTGTTTATTGCGATCAAGAGACCAGTTTGGGAGGATGGCTTTTGATCCAGCAAAG
AATGGATGGATCACTGAATTTTAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAGCCTG
AATGACGAGGGGGAAGGAGAATTCTGGCTAGGCAATGACTACCTCCACTTACTAACCCAAAGGG
GCTCTGTTCTTAGGGTTGAATTAGAGGACTGGGCTGGGAATGAAGCTTATGCAGAATATCACTT
CCGGGTAGGCTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTATGAAGGCACTGCGGGT
GATGCTCTGATTGAGGGTTCCGTAGAGGAAGGGGCAGAGTACACCTCTCACAACAACATGCAGT
TCAGCACCTTTGACAGGGATGCAGACCAGTGGGAAGAGAACTGTGCAGAAGTCTATGGGGGAGG
CTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAATGGAATCTACTACCCTGGGGGCTCCTAT
GACCCAAGGAATAACAGTCCTTATGAGATTGAGAATGGAGTGGTCTGGGTTTCCTTTAGAGGGG
CAGATTATTCCCTCAGGGCTGTTCGCATGAAAATTAGGCCCCTTGTGACCCAATAGGCTGAAGA
AGTGGGAATGGGAGCACTCTGTCTTCTTTGCTAGAGAAGTGGAGAGAAAATACAAAAGGTAAAG
CAGTTGAGATTCTCTACAACCTAAAAAATTCCTAGGTGCTATTTTCTTATCCTTTGTACTGTAG
CTAAATGTACCTGAGACATATTAGTCTTTGAAAAATAAAGTTATGTAAGGTTTTTTTTATCTTT
AAATAGCTCTGTGGGTTTTAACATTTTTATAAAGATATACCAAGGGCCATTCAGTACATCAGGA
AAGTGGCAGACAGAAGCTTCTCTCTGCAACCTTGAAGACTATTGGTTTGAGAACTTCTCTTCCC
ATACCACCCAAAATCATAATGCCATTGGAAAGCAAAAAGTTGTTTTATCCATTTGATTTGAATT
GTTTTAAGCCAATATTTTAAGGTAAAACTCACTGAATCTAACCATAGCTGACCTTTGTAGTAGA
ATTTACAACTTATAATTACAATGCACAATTTATAATTACAATATGTATTTATGTCTTTTGCTAT
GGAGCAAATCCAGGAAGGCAAGAGAAACATTCTTTCCTAAATATAAATGAAAATCTATCCTTTA
AACTCTTCCACTAGACGTTGTAATGCACACTTATTTTTTTCCCAAGGAGTAACCAATTTCTTTC
TAAAACACATTTAAAATTTTAAAACTATTTATGAATATTAAAAAAAGACATAATTCACACATTA
ATAAACAATCTCCCAAGTATTGATTTAACTTCATTTTTCTAATAATCATAAACTATATTCTGTG
ACATGCTAATTATTATTAAATGTAAGTCGTTAGTTCGAAAGCCTCTCACTAAGTATGATCTATG
CTATATTCAAAATTCAACCCATTTACTTTGGTCAATATTTGATCTAAGTTGCATCTTTAATCCT
GGTGGTCTTGCCTTCTGATTTTTAATTTGTATCCTTTTCTATTAAGATATATTTGTCATTTTCT
CTTGAATATGTATTAAAATATCCCAAGCAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_021871 ⟹ NP_068657

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	154,585,275 - 154,590,742 (-)	NCBI
GRCh37	4	155,504,280 - 155,511,897 (-)	ENTREZGENE
Build 36	4	155,725,879 - 155,731,347 (-)	NCBI Archive
HuRef	4	151,244,861 - 151,252,473 (-)	ENTREZGENE
CHM1_1	4	155,484,333 - 155,489,839 (-)	NCBI

Sequence:

show sequence

AGGATGGGAACTAGGAGTGGCAGCAATCCTTTCTTTCAGCTGGAGTGCTCCTCAGGAGCCAGCC
CCACCCTTAGAAAAGATGTTTTCCATGAGGATCGTCTGCCTGGTCCTAAGTGTGGTGGGCACAG
CATGGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAG
GGTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGAC
TGGAACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATT
TTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAACAATAAGGATTC
TCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGT
GATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAG
TCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAATGTTAGAGCTCAGTTGGTTGATAT
GAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCT
TTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTG
CCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAATGAAACCAGTTCC
AGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTA
ACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAG
GCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAG
CTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACT
GGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTG
GGAGCTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGG
AACCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTA
TCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTG
GGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCC
AGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGG
ACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCG
TTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGA
AGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGAT
GGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGGAAAAACAT
TCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGA
ATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCT
TCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAG
ACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGA
AGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGGTATCCACACTTCT
CCTTTGGGGAAGCCTTCCCTGTCCCCCTAGACTAAGTTAAATATTTCTGCACAGTGTTCCCATG
GCCCCTTGCATTTCCTTCTTAACTCTCTGTTACACGTCATTGAAACTACACTTTTTTGGTCTGT
TTTTGTGCTAGACTGTAAGTTCCTTGGGGGCAGGGCCTTTGTCTGTCTCATCTCTGTATTCCCA
AATGCCTAACAGTACAGAGCCATGACTCAATAAATACATGTTAAATGGATGAATGAATTCCTCT
GAAACTCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_000499	(Get FASTA)	NCBI Sequence Viewer
	NP_068657	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA17055	(Get FASTA)	NCBI Sequence Viewer
	AAA17056	(Get FASTA)	NCBI Sequence Viewer
	AAA52426	(Get FASTA)	NCBI Sequence Viewer
	AAA52427	(Get FASTA)	NCBI Sequence Viewer
	AAA52428	(Get FASTA)	NCBI Sequence Viewer
	AAA52444	(Get FASTA)	NCBI Sequence Viewer
	AAB47117	(Get FASTA)	NCBI Sequence Viewer
	AAC97142	(Get FASTA)	NCBI Sequence Viewer
	AAC97143	(Get FASTA)	NCBI Sequence Viewer
	AAH20764	(Get FASTA)	NCBI Sequence Viewer
	AAH70246	(Get FASTA)	NCBI Sequence Viewer
	AAH98280	(Get FASTA)	NCBI Sequence Viewer
	AAH99706	(Get FASTA)	NCBI Sequence Viewer
	AAH99720	(Get FASTA)	NCBI Sequence Viewer
	AAI01936	(Get FASTA)	NCBI Sequence Viewer
	AAI05804	(Get FASTA)	NCBI Sequence Viewer
	AAK31372	(Get FASTA)	NCBI Sequence Viewer
	AAK31373	(Get FASTA)	NCBI Sequence Viewer
	ALQ33520	(Get FASTA)	NCBI Sequence Viewer
	ALQ33521	(Get FASTA)	NCBI Sequence Viewer
	ALQ33522	(Get FASTA)	NCBI Sequence Viewer
	ALQ33523	(Get FASTA)	NCBI Sequence Viewer
	BAC55116	(Get FASTA)	NCBI Sequence Viewer
	BAF83248	(Get FASTA)	NCBI Sequence Viewer
	CDL78900	(Get FASTA)	NCBI Sequence Viewer
	EAX04924	(Get FASTA)	NCBI Sequence Viewer
	EAX04925	(Get FASTA)	NCBI Sequence Viewer
	EAX04926	(Get FASTA)	NCBI Sequence Viewer
	EAX04927	(Get FASTA)	NCBI Sequence Viewer
	EAX04928	(Get FASTA)	NCBI Sequence Viewer
	P02671	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_000499 ⟸ NM_000508
- Peptide Label:	isoform alpha-E preproprotein
- UniProtKB:	P02671 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKC PSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREV DLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQ MRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTAT WKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTG QWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEK VTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHR HPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKS SSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHP SGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGE GEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIE GSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNN SPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ hide sequence

RefSeq Acc Id:	NP_068657 ⟸ NM_021871
- Peptide Label:	isoform alpha precursor
- UniProtKB:	P02671 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKC PSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREV DLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQ MRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTAT WKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTG QWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEK VTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHR HPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKS SSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRGIHTSPLGKP SLSP hide sequence

RefSeq Acc Id:

ENSP00000478487 ⟸ ENST00000622532

RefSeq Acc Id:

ENSP00000498441 ⟸ ENST00000651975

RefSeq Acc Id:

ENSP00000385981 ⟸ ENST00000403106

Protein Domains

Fib_alpha Fibrinogen C-terminal

Promoters

RGD ID:

6868708

Promoter ID:

EPDNEW_H7519

Type:

initiation region

Name:

FGA_1

Description:

fibrinogen alpha chain

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	154,590,742 - 154,590,802	EPDNEW

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_021871.4(FGA):c.104G>A (p.Arg35His)	single nucleotide variant	Abnormal bleeding [RCV000851971]\|Dysfibrinogenemia [RCV000030941]\|Hypofibrinogenemia [RCV000851581]	Chr4:154589513 [GRCh38] Chr4:155510665 [GRCh37] Chr4:4q31.3	pathogenic\|other
NM_000508.3(FGA):c.76G>A (p.Asp26Asn)	single nucleotide variant	FIBRINOGEN LILLE 1 [RCV000017823]	Chr4:154589541 [GRCh38] Chr4:155510693 [GRCh37] Chr4:4q31.3	other
NM_000508.3(FGA):c.92G>T (p.Gly31Val)	single nucleotide variant	FIBRINOGEN ROUEN 1 [RCV000017824]	Chr4:154589525 [GRCh38] Chr4:155510677 [GRCh37] Chr4:4q31.3	other
NM_000508.3(FGA):c.103C>T (p.Arg35Cys)	single nucleotide variant	Dysfibrinogenemia [RCV000017825]	Chr4:154589514 [GRCh38] Chr4:155510666 [GRCh37] Chr4:4q31.3	pathogenic\|other
FIBRINOGEN MUNICH 1	variation	FIBRINOGEN MUNICH 1 [RCV000017841]	Chr4:4q28	other
FIBRINOGEN DETROIT 1	variation	FIBRINOGEN DETROIT 1 [RCV000017842]	Chr4:4q28	other
NM_000508.3(FGA):c.112A>G (p.Arg38Gly)	single nucleotide variant	FIBRINOGEN AARHUS 1 [RCV000017843]\|Hypofibrinogenemia [RCV000851993]	Chr4:154589505 [GRCh38] Chr4:155510657 [GRCh37] Chr4:4q31.3	likely pathogenic\|other
NM_000508.3(FGA):c.110C>T (p.Pro37Leu)	single nucleotide variant	FIBRINOGEN KYOTO 2 [RCV000017844]	Chr4:154589507 [GRCh38] Chr4:155510659 [GRCh37] Chr4:4q31.3	other
NM_000508.3(FGA):c.1358G>A (p.Ser453Asn)	single nucleotide variant	FIBRINOGEN CARACAS 2 [RCV000017865]	Chr4:154586071 [GRCh38] Chr4:155507223 [GRCh37] Chr4:4q31.3	other
FIBRINOGEN LIMA	variation	FIBRINOGEN LIMA [RCV000017866]	Chr4:4q28	other
NM_000508.3(FGA):c.1438A>T (p.Lys480Ter)	single nucleotide variant	FIBRINOGEN MARBURG [RCV000017867]	Chr4:154585991 [GRCh38] Chr4:155507143 [GRCh37] Chr4:4q31.3	pathogenic\|other
NM_021871.4(FGA):c.1718G>T (p.Arg573Leu)	single nucleotide variant	Familial visceral amyloidosis, Ostertag type [RCV000017869]	Chr4:154585711 [GRCh38] Chr4:155506863 [GRCh37] Chr4:4q31.3	pathogenic
NM_021871.4(FGA):c.1622del (p.Val541fs)	deletion	Familial visceral amyloidosis, Ostertag type [RCV000017870]	Chr4:154585807 [GRCh38] Chr4:155506959 [GRCh37] Chr4:4q31.3	pathogenic
NM_021871.4(FGA):c.1634A>T (p.Glu545Val)	single nucleotide variant	Familial visceral amyloidosis, Ostertag type [RCV000017871]	Chr4:154585795 [GRCh38] Chr4:155506947 [GRCh37] Chr4:4q31.3	pathogenic
NM_000508.3(FGA):c.1717C>T (p.Arg573Cys)	single nucleotide variant	FIBRINOGEN DUSART [RCV000017872]	Chr4:154585712 [GRCh38] Chr4:155506864 [GRCh37] Chr4:4q31.3	other
NM_000508.3(FGA):c.116T>A (p.Val39Asp)	single nucleotide variant	FIBRINOGEN CANTERBURY [RCV000017874]	Chr4:154589501 [GRCh38] Chr4:155510653 [GRCh37] Chr4:4q31.3	other
NM_021871.4(FGA):c.1629del (p.Thr544fs)	deletion	Familial visceral amyloidosis, Ostertag type [RCV000017875]	Chr4:154585800 [GRCh38] Chr4:155506952 [GRCh37] Chr4:4q31.3	pathogenic
NC_000004.12:g.(154580323_154580329)_(154590210_154590216)del	deletion	Afibrinogenemia, congenital [RCV000017876]	Chr4:154580329..154590210 [GRCh38] Chr4:4q28	pathogenic
NM_021871.4(FGA):c.510+1G>T	single nucleotide variant	Afibrinogenemia, congenital [RCV000017877]\|Hypodysfibrinogenemia, congenital [RCV000030942]\|Hypofibrinogenemia [RCV000851811]	Chr4:154587511 [GRCh38] Chr4:155508663 [GRCh37] Chr4:4q31.3	pathogenic
FIBRINOGEN NIEUWEGEIN	insertion	FIBRINOGEN NIEUWEGEIN [RCV000017878]	Chr4:4q28	other
NM_021871.4(FGA):c.711dup (p.Lys238Ter)	duplication	Afibrinogenemia, congenital [RCV000017879]	Chr4:154586717..154586718 [GRCh38] Chr4:155507869..155507870 [GRCh37] Chr4:4q31.3	pathogenic
NM_000508.3(FGA):c.1039C>T (p.Gln347Ter)	single nucleotide variant	FIBRINOGEN KEOKUK [RCV000017880]	Chr4:154586390 [GRCh38] Chr4:155507542 [GRCh37] Chr4:4q31.3	other
NM_021871.4(FGA):c.991A>G (p.Thr331Ala)	single nucleotide variant	Afibrinogenemia, congenital [RCV000338448]\|Familial visceral amyloidosis, Ostertag type [RCV000405212]\|Venous thromboembolism, susceptibility to [RCV000017882]\|not specified [RCV000246757]	Chr4:154586438 [GRCh38] Chr4:155507590 [GRCh37] Chr4:4q31.3	risk factor\|benign
NM_000508.5(FGA):c.2153C>A (p.Thr718Asn)	single nucleotide variant	not provided [RCV000722728]	Chr4:154584572 [GRCh38] Chr4:155505724 [GRCh37] Chr4:4q31.3	uncertain significance
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3	copy number gain	See cases [RCV000051785]	Chr4:118065569..190042639 [GRCh38] Chr4:118986724..190828225 [GRCh37] Chr4:119206172..191200788 [NCBI36] Chr4:4q26-35.2	pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3	copy number gain	See cases [RCV000051786]	Chr4:121518223..190062270 [GRCh38] Chr4:122439378..190828225 [GRCh37] Chr4:122658828..191220419 [NCBI36] Chr4:4q27-35.2	pathogenic
GRCh38/hg38 4q31.22-34.1(chr4:147317283-173675559)x3	copy number gain	See cases [RCV000051788]	Chr4:147317283..173675559 [GRCh38] Chr4:148238435..174596710 [GRCh37] Chr4:148457885..174833285 [NCBI36] Chr4:4q31.22-34.1	pathogenic
GRCh38/hg38 4q31.23-35.2(chr4:148356485-189548183)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]\|See cases [RCV000051789]	Chr4:148356485..189548183 [GRCh38] Chr4:149277637..190469337 [GRCh37] Chr4:149497087..190706331 [NCBI36] Chr4:4q31.23-35.2	pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]\|See cases [RCV000051775]	Chr4:92913386..165299707 [GRCh38] Chr4:93834537..166220859 [GRCh37] Chr4:94053560..166440309 [NCBI36] Chr4:4q22.2-32.3	pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:153656785-154928773)x1	copy number loss	See cases [RCV000053324]	Chr4:153656785..154928773 [GRCh38] Chr4:154577937..155849925 [GRCh37] Chr4:154797387..156069375 [NCBI36] Chr4:4q31.3-32.1	pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:151299810-160314050)x1	copy number loss	See cases [RCV000135696]	Chr4:151299810..160314050 [GRCh38] Chr4:152220962..161235202 [GRCh37] Chr4:152440412..161454652 [NCBI36] Chr4:4q31.3-32.1	likely pathogenic
GRCh38/hg38 4q31.21-35.2(chr4:145042668-189975519)x3	copy number gain	See cases [RCV000135845]	Chr4:145042668..189975519 [GRCh38] Chr4:145963820..190828225 [GRCh37] Chr4:146183270..191133668 [NCBI36] Chr4:4q31.21-35.2	pathogenic
GRCh38/hg38 4q31.1-35.2(chr4:138510532-189963195)x3	copy number gain	See cases [RCV000136810]	Chr4:138510532..189963195 [GRCh38] Chr4:139431686..190828225 [GRCh37] Chr4:139651136..191121344 [NCBI36] Chr4:4q31.1-35.2	pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:131985253-190095391)x3	copy number gain	See cases [RCV000137721]	Chr4:131985253..190095391 [GRCh38] Chr4:132906408..190828225 [GRCh37] Chr4:133125858..191250527 [NCBI36] Chr4:4q28.3-35.2	pathogenic\|likely benign
GRCh38/hg38 4q28.1-35.1(chr4:125432943-185761887)x3	copy number gain	See cases [RCV000138578]	Chr4:125432943..185761887 [GRCh38] Chr4:126354098..186683041 [GRCh37] Chr4:126573548..186920035 [NCBI36] Chr4:4q28.1-35.1	pathogenic\|likely benign
GRCh38/hg38 4q28.3-35.2(chr4:134935616-190036318)x3	copy number gain	See cases [RCV000143559]	Chr4:134935616..190036318 [GRCh38] Chr4:135856771..190957473 [GRCh37] Chr4:136076221..191194467 [NCBI36] Chr4:4q28.3-35.2	pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:152500649-155788803)x3	copy number gain	See cases [RCV000143617]	Chr4:152500649..155788803 [GRCh38] Chr4:153421801..156709955 [GRCh37] Chr4:153641251..156929405 [NCBI36] Chr4:4q31.3-32.1	likely pathogenic
GRCh37/hg19 4q28.3-35.1(chr4:136912336-184253252)x3	copy number gain	See cases [RCV000240245]	Chr4:136912336..184253252 [GRCh37] Chr4:4q28.3-35.1	pathogenic
NM_021871.4(FGA):c.923G>A (p.Arg308Gln)	single nucleotide variant	Afibrinogenemia, congenital [RCV001148495]\|Familial visceral amyloidosis, Ostertag type [RCV001148496]\|not provided [RCV000224629]	Chr4:154586506 [GRCh38] Chr4:155507658 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.616C>G (p.Gln206Glu)	single nucleotide variant	Afibrinogenemia, congenital [RCV000279650]\|Familial visceral amyloidosis, Ostertag type [RCV000371491]	Chr4:154586813 [GRCh38] Chr4:155507965 [GRCh37] Chr4:4q31.3	likely benign\|uncertain significance
NM_021871.4(FGA):c.450G>A (p.Gln150=)	single nucleotide variant	Afibrinogenemia, congenital [RCV000340627]\|Familial visceral amyloidosis, Ostertag type [RCV000283016]	Chr4:154587572 [GRCh38] Chr4:155508724 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.904C>G (p.Pro302Ala)	single nucleotide variant	Afibrinogenemia, congenital [RCV000307705]\|Familial visceral amyloidosis, Ostertag type [RCV000268329]\|not provided [RCV000973688]	Chr4:154586525 [GRCh38] Chr4:155507677 [GRCh37] Chr4:4q31.3	benign\|likely benign
NM_000508.5(FGA):c.2586C>T (p.Pro862=)	single nucleotide variant	not provided [RCV000961585]\|not specified [RCV000241967]	Chr4:154584139 [GRCh38] Chr4:155505291 [GRCh37] Chr4:4q31.3	benign
NM_021871.4(FGA):c.1823G>C (p.Gly608Ala)	single nucleotide variant	Afibrinogenemia, congenital [RCV000328375]\|Familial visceral amyloidosis, Ostertag type [RCV000270905]	Chr4:154585606 [GRCh38] Chr4:155506758 [GRCh37] Chr4:4q31.3	likely benign\|uncertain significance
NM_000508.5(FGA):c.7_34dup	duplication	not specified [RCV000247066]	Chr4:154584089..154584090 [GRCh38] Chr4:155505241..155505242 [GRCh37] Chr4:4q31.3	benign
NM_021871.4(FGA):c.-14C>T	single nucleotide variant	not specified [RCV000250194]	Chr4:154590701 [GRCh38] Chr4:155511853 [GRCh37] Chr4:4q31.3	likely benign
NM_021871.4(FGA):c.*50T>G	single nucleotide variant	Afibrinogenemia, congenital [RCV000266418]\|Familial visceral amyloidosis, Ostertag type [RCV000358780]	Chr4:154585444 [GRCh38] Chr4:155506596 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3	copy number gain	See cases [RCV000240392]	Chr4:119437495..190904301 [GRCh37] Chr4:4q26-35.2	pathogenic
NM_021871.4(FGA):c.1199C>T (p.Ser400Phe)	single nucleotide variant	Afibrinogenemia, congenital [RCV000299895]\|Familial visceral amyloidosis, Ostertag type [RCV000404272]	Chr4:154586230 [GRCh38] Chr4:155507382 [GRCh37] Chr4:4q31.3	benign\|likely benign
NM_021871.4(FGA):c.919A>G (p.Asn307Asp)	single nucleotide variant	Afibrinogenemia, congenital [RCV000360629]\|Familial visceral amyloidosis, Ostertag type [RCV000303506]	Chr4:154586510 [GRCh38] Chr4:155507662 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.1542T>C (p.Pro514=)	single nucleotide variant	Afibrinogenemia, congenital [RCV000385254]\|Familial visceral amyloidosis, Ostertag type [RCV000293267]\|not provided [RCV000946817]	Chr4:154585887 [GRCh38] Chr4:155507039 [GRCh37] Chr4:4q31.3	benign\|likely benign
NM_021871.4(FGA):c.1838A>G (p.His613Arg)	single nucleotide variant	Afibrinogenemia, congenital [RCV000381748]\|Familial visceral amyloidosis, Ostertag type [RCV000323812]	Chr4:154585591 [GRCh38] Chr4:155506743 [GRCh37] Chr4:4q31.3	benign\|likely benign\|uncertain significance
NM_021871.4(FGA):c.244A>C (p.Thr82Pro)	single nucleotide variant	Afibrinogenemia, congenital [RCV000344051]\|Familial visceral amyloidosis, Ostertag type [RCV000404726]	Chr4:154588913 [GRCh38] Chr4:155510065 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.16A>G (p.Ile6Val)	single nucleotide variant	Afibrinogenemia, congenital [RCV000366318]\|Familial visceral amyloidosis, Ostertag type [RCV000309151]\|not provided [RCV000953503]	Chr4:154590672 [GRCh38] Chr4:155511824 [GRCh37] Chr4:4q31.3	benign
NM_021871.4(FGA):c.1417G>A (p.Asp473Asn)	single nucleotide variant	Afibrinogenemia, congenital [RCV000296696]\|Familial visceral amyloidosis, Ostertag type [RCV000334967]	Chr4:154586012 [GRCh38] Chr4:155507164 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.765G>A (p.Pro255=)	single nucleotide variant	Afibrinogenemia, congenital [RCV000386537]\|Familial visceral amyloidosis, Ostertag type [RCV000329775]	Chr4:154586664 [GRCh38] Chr4:155507816 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.3(FGA):c.-58A>G	single nucleotide variant	Afibrinogenemia, congenital [RCV000396755]\|Familial visceral amyloidosis, Ostertag type [RCV000312840]	Chr4:154590745 [GRCh38] Chr4:155511897 [GRCh37] Chr4:4q31.3	benign
NM_021871.4(FGA):c.1444G>A (p.Val482Met)	single nucleotide variant	Afibrinogenemia, congenital [RCV000388685]\|Familial visceral amyloidosis, Ostertag type [RCV000350523]	Chr4:154585985 [GRCh38] Chr4:155507137 [GRCh37] Chr4:4q31.3	likely benign
NM_021871.4(FGA):c.822C>T (p.Ser274=)	single nucleotide variant	Afibrinogenemia, congenital [RCV000364658]\|Familial visceral amyloidosis, Ostertag type [RCV000272340]	Chr4:154586607 [GRCh38] Chr4:155507759 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.666A>T (p.Pro222=)	single nucleotide variant	Afibrinogenemia, congenital [RCV000275684]\|Familial visceral amyloidosis, Ostertag type [RCV000333223]	Chr4:154586763 [GRCh38] Chr4:155507915 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.346G>A (p.Asp116Asn)	single nucleotide variant	Afibrinogenemia, congenital [RCV000402806]\|Familial visceral amyloidosis, Ostertag type [RCV000305519]	Chr4:154588811 [GRCh38] Chr4:155509963 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.614A>G (p.Glu205Gly)	single nucleotide variant	Afibrinogenemia, congenital [RCV000337081]\|Familial visceral amyloidosis, Ostertag type [RCV000375396]	Chr4:154586815 [GRCh38] Chr4:155507967 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.193C>A (p.Pro65Thr)	single nucleotide variant	not provided [RCV000722253]	Chr4:154588964 [GRCh38] Chr4:155510116 [GRCh37] Chr4:4q31.3	uncertain significance
NM_000508.5(FGA):c.2434T>C (p.Cys812Arg)	single nucleotide variant	not provided [RCV000722976]	Chr4:154584291 [GRCh38] Chr4:155505443 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.502C>T (p.Arg168Ter)	single nucleotide variant	Afibrinogenemia, congenital [RCV000454272]	Chr4:154587520 [GRCh38] Chr4:155508672 [GRCh37] Chr4:4q31.3	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3	copy number gain	See cases [RCV000446653]	Chr4:12440..190904441 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)	copy number gain	See cases [RCV000510453]	Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q31.3-35.2(chr4:153890440-190957473)x3	copy number gain	See cases [RCV000510713]	Chr4:153890440..190957473 [GRCh37] Chr4:4q31.3-35.2	pathogenic
GRCh37/hg19 4q31.3-32.2(chr4:153203431-162912359)x1	copy number loss	See cases [RCV000511404]	Chr4:153203431..162912359 [GRCh37] Chr4:4q31.3-32.2	pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3	copy number gain	See cases [RCV000511945]	Chr4:109199664..189752726 [GRCh37] Chr4:4q25-35.2	pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3	copy number gain	See cases [RCV000510970]	Chr4:93071152..190957473 [GRCh37] Chr4:4q22.1-35.2	pathogenic
NM_000508.5(FGA):c.2089G>A (p.Gly697Ser)	single nucleotide variant	AFib amyloidosis [RCV000627058]	Chr4:154584636 [GRCh38] Chr4:155505788 [GRCh37] Chr4:4q31.3	uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3	copy number gain	See cases [RCV000512241]	Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q31.3-32.1(chr4:154763131-158404825)x1	copy number loss	not provided [RCV000682474]	Chr4:154763131..158404825 [GRCh37] Chr4:4q31.3-32.1	likely pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3	copy number gain	not provided [RCV000743155]	Chr4:49450..190915650 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3	copy number gain	not provided [RCV000743156]	Chr4:49450..190963766 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3	copy number gain	not provided [RCV000743147]	Chr4:11525..191028879 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
NM_021871.4(FGA):c.*133G>A	single nucleotide variant	Afibrinogenemia, congenital [RCV001148383]\|Familial visceral amyloidosis, Ostertag type [RCV001148384]	Chr4:154585361 [GRCh38] Chr4:155506513 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.1025G>A (p.Gly342Glu)	single nucleotide variant	Afibrinogenemia, congenital [RCV001148494]\|Familial visceral amyloidosis, Ostertag type [RCV001148493]	Chr4:154586404 [GRCh38] Chr4:155507556 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.780G>A (p.Glu260=)	single nucleotide variant	not provided [RCV000879648]	Chr4:154586649 [GRCh38] Chr4:155507801 [GRCh37] Chr4:4q31.3	benign
NM_021871.4(FGA):c.811C>T (p.Arg271Ter)	single nucleotide variant	Afibrinogenemia, congenital [RCV000984799]	Chr4:154586618 [GRCh38] Chr4:155507770 [GRCh37] Chr4:4q31.3	pathogenic
NM_021871.4(FGA):c.1103del (p.Gly368fs)	deletion	FGA-Related Disorders [RCV000779433]	Chr4:154586326 [GRCh38] Chr4:155507478 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.300G>A (p.Lys100=)	single nucleotide variant	Afibrinogenemia, congenital [RCV001143942]\|Familial visceral amyloidosis, Ostertag type [RCV001143941]\|not provided [RCV000964974]	Chr4:154588857 [GRCh38] Chr4:155510009 [GRCh37] Chr4:4q31.3	benign\|likely benign
NM_021871.4(FGA):c.1155A>G (p.Gln385=)	single nucleotide variant	not provided [RCV000921628]	Chr4:154586274 [GRCh38] Chr4:155507426 [GRCh37] Chr4:4q31.3	likely benign
NM_021871.4(FGA):c.1366A>G (p.Thr456Ala)	single nucleotide variant	Abnormal bleeding [RCV001270514]\|Afibrinogenemia, congenital [RCV001145722]\|Familial visceral amyloidosis, Ostertag type [RCV001145723]\|not provided [RCV000964973]	Chr4:154586063 [GRCh38] Chr4:155507215 [GRCh37] Chr4:4q31.3	benign\|likely benign\|uncertain significance
NM_021871.4(FGA):c.532C>T (p.Arg178Ter)	single nucleotide variant	FGA-Related Disorders [RCV000779434]	Chr4:154586897 [GRCh38] Chr4:155508049 [GRCh37] Chr4:4q31.3	likely pathogenic
NM_021871.4(FGA):c.187A>T (p.Lys63Ter)	single nucleotide variant	FGA-Related Disorders [RCV000779435]	Chr4:154588970 [GRCh38] Chr4:155510122 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.103C>A (p.Arg35Ser)	single nucleotide variant	Hypofibrinogenemia [RCV000851968]	Chr4:154589514 [GRCh38] Chr4:155510666 [GRCh37] Chr4:4q31.3	pathogenic
GRCh37/hg19 4q31.3-32.1(chr4:154907679-159012980)x1	copy number loss	not provided [RCV000848578]	Chr4:154907679..159012980 [GRCh37] Chr4:4q31.3-32.1	uncertain significance
NM_021871.4(FGA):c.1912G>A (p.Gly638Arg)	single nucleotide variant	Afibrinogenemia, congenital [RCV001149944]\|Familial visceral amyloidosis, Ostertag type [RCV001149943]	Chr4:154585517 [GRCh38] Chr4:155506669 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.1207G>A (p.Ala403Thr)	single nucleotide variant	Afibrinogenemia, congenital [RCV001145724]\|Familial visceral amyloidosis, Ostertag type [RCV001145725]	Chr4:154586222 [GRCh38] Chr4:155507374 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.1918C>G (p.Pro640Ala)	single nucleotide variant	Afibrinogenemia, congenital [RCV001149941]\|Familial visceral amyloidosis, Ostertag type [RCV001149942]	Chr4:154585511 [GRCh38] Chr4:155506663 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.1072G>A (p.Gly358Arg)	single nucleotide variant	Afibrinogenemia, congenital [RCV001145727]\|Familial visceral amyloidosis, Ostertag type [RCV001145726]	Chr4:154586357 [GRCh38] Chr4:155507509 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
GRCh37/hg19 4q31.3-35.2(chr4:151174061-190957473)x3	copy number gain	not provided [RCV000849098]	Chr4:151174061..190957473 [GRCh37] Chr4:4q31.3-35.2	pathogenic
NM_021871.4(FGA):c.104G>C (p.Arg35Pro)	single nucleotide variant	Hypofibrinogenemia [RCV000851972]	Chr4:154589513 [GRCh38] Chr4:155510665 [GRCh37] Chr4:4q31.3	pathogenic
NM_021871.4(FGA):c.327_337del (p.Met110fs)	deletion	not provided [RCV001008940]	Chr4:154588820..154588830 [GRCh38] Chr4:155509972..155509982 [GRCh37] Chr4:4q31.3	pathogenic
NM_021871.4(FGA):c.922C>T (p.Arg308Ter)	single nucleotide variant	Hypofibrinogenemia [RCV000852248]	Chr4:154586507 [GRCh38] Chr4:155507659 [GRCh37] Chr4:4q31.3	likely pathogenic
NM_021871.4(FGA):c.1621G>C (p.Val541Leu)	single nucleotide variant	Familial visceral amyloidosis, Ostertag type [RCV000987481]	Chr4:154585808 [GRCh38] Chr4:155506960 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.1718G>A (p.Arg573His)	single nucleotide variant	Afibrinogenemia, congenital [RCV001145522]\|Familial visceral amyloidosis, Ostertag type [RCV001145521]	Chr4:154585711 [GRCh38] Chr4:155506863 [GRCh37] Chr4:4q31.3	benign\|uncertain significance
NM_021871.4(FGA):c.945del (p.Gly316fs)	deletion	Hypofibrinogenemia [RCV000851912]	Chr4:154586484 [GRCh38] Chr4:155507636 [GRCh37] Chr4:4q31.3	pathogenic
NM_021871.4(FGA):c.1472G>A (p.Cys491Tyr)	single nucleotide variant	Hypofibrinogenemia [RCV000852035]	Chr4:154585957 [GRCh38] Chr4:155507109 [GRCh37] Chr4:4q31.3	likely pathogenic
GRCh37/hg19 4q28.1-35.1(chr4:124873497-185278662)x3	copy number gain	not provided [RCV000849686]	Chr4:124873497..185278662 [GRCh37] Chr4:4q28.1-35.1	pathogenic
NM_021871.4(FGA):c.117del (p.Val40fs)	deletion	Hypofibrinogenemia [RCV000852003]	Chr4:154589500 [GRCh38] Chr4:155510652 [GRCh37] Chr4:4q31.3	likely pathogenic
NM_021871.4(FGA):c.1760C>G (p.Thr587Arg)	single nucleotide variant	Familial visceral amyloidosis, Ostertag type [RCV000855410]	Chr4:154585669 [GRCh38] Chr4:155506821 [GRCh37] Chr4:4q31.3	uncertain significance
NM_000508.5(FGA):c.2244T>C (p.Ala748=)	single nucleotide variant	not provided [RCV000886341]	Chr4:154584481 [GRCh38] Chr4:155505633 [GRCh37] Chr4:4q31.3	likely benign
NM_021871.4(FGA):c.1560C>T (p.Phe520=)	single nucleotide variant	not provided [RCV000933781]	Chr4:154585869 [GRCh38] Chr4:155507021 [GRCh37] Chr4:4q31.3	likely benign
NM_000508.5(FGA):c.2587del (p.Leu863_Val864insTer)	deletion	Familial visceral amyloidosis, Ostertag type [RCV000987480]	Chr4:154584138 [GRCh38] Chr4:155505290 [GRCh37] Chr4:4q31.3	benign
NM_021871.4(FGA):c.1113del (p.His372fs)	deletion	not provided [RCV001008260]	Chr4:154586316 [GRCh38] Chr4:155507468 [GRCh37] Chr4:4q31.3	likely pathogenic
NM_021871.4(FGA):c.181-14C>T	single nucleotide variant	Afibrinogenemia, congenital [RCV001145838]\|Familial visceral amyloidosis, Ostertag type [RCV001145837]	Chr4:154588990 [GRCh38] Chr4:155510142 [GRCh37] Chr4:4q31.3	benign\|likely benign
GRCh37/hg19 4q31.3-32.1(chr4:153061243-157994448)x1	copy number loss	not provided [RCV001005606]	Chr4:153061243..157994448 [GRCh37] Chr4:4q31.3-32.1	likely pathogenic
NM_021871.4(FGA):c.1615G>A (p.Glu539Lys)	single nucleotide variant	Familial visceral amyloidosis, Ostertag type [RCV001200879]	Chr4:154585814 [GRCh38] Chr4:155506966 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.215G>A (p.Gly72Glu)	single nucleotide variant	Familial visceral amyloidosis, Ostertag type [RCV001251021]	Chr4:154588942 [GRCh38] Chr4:155510094 [GRCh37] Chr4:4q31.3	uncertain significance
NM_021871.4(FGA):c.8C>T (p.Ser3Phe)	single nucleotide variant	not provided [RCV001338449]	Chr4:154590680 [GRCh38] Chr4:155511832 [GRCh37] Chr4:4q31.3	uncertain significance

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:3661	AgrOrtholog
COSMIC	FGA	COSMIC
Ensembl Genes	ENSG00000171560	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSP00000385981	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000478487	UniProtKB/TrEMBL
	ENSP00000498441	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000403106	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000622532	UniProtKB/TrEMBL
	ENST00000651975	ENTREZGENE, UniProtKB/Swiss-Prot
GTEx	ENSG00000171560	GTEx
HGNC ID	HGNC:3661	ENTREZGENE
Human Proteome Map	FGA	Human Proteome Map
InterPro	Fibrinogen-like_C	UniProtKB/Swiss-Prot
	Fibrinogen_a/b/g_C_dom	UniProtKB/Swiss-Prot
	Fibrinogen_a/b/g_coil_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibrinogen_aC	UniProtKB/Swiss-Prot
	Fibrinogen_alpha	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibrinogen_CS	UniProtKB/Swiss-Prot
KEGG Report	hsa:2243	UniProtKB/Swiss-Prot
NCBI Gene	2243	ENTREZGENE
OMIM	105200	OMIM
	134820	OMIM
	202400	OMIM
	616004	OMIM
PANTHER	PTHR47221	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Fib_alpha	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibrinogen_aC	UniProtKB/Swiss-Prot
	Fibrinogen_C	UniProtKB/Swiss-Prot
PharmGKB	PA429	PharmGKB
PROSITE	FIBRINOGEN_C_1	UniProtKB/Swiss-Prot
	FIBRINOGEN_C_2	UniProtKB/Swiss-Prot
SMART	FBG	UniProtKB/Swiss-Prot
	Fib_alpha	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56496	UniProtKB/Swiss-Prot
UniProt	A0A087WUA0_HUMAN	UniProtKB/TrEMBL
	A0A0S2Z3E8_HUMAN	UniProtKB/TrEMBL
	A0A0S2Z3E9_HUMAN	UniProtKB/TrEMBL
	A0A0S2Z3M3_HUMAN	UniProtKB/TrEMBL
	A0A0S2Z3P3_HUMAN	UniProtKB/TrEMBL
	FIBA_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q3KRA7_HUMAN	UniProtKB/TrEMBL
	Q6NSD8_HUMAN	UniProtKB/TrEMBL
	Q86Z09_HUMAN	UniProtKB/TrEMBL
	Q8WW76_HUMAN	UniProtKB/TrEMBL
UniProt Secondary	A8K3E4	UniProtKB/Swiss-Prot
	D3DP14	UniProtKB/Swiss-Prot
	D3DP15	UniProtKB/Swiss-Prot
	Q4QQH7	UniProtKB/Swiss-Prot
	Q9BX62	UniProtKB/Swiss-Prot
	Q9UCH2	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)