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Gene: IRF8 (interferon regulatory factor 8) Homo sapiens
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Symbol: IRF8
Name: interferon regulatory factor 8
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in cellular response to interferon-gamma; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Localizes to the cytoplasm and nucleoplasm. Implicated in primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; interferon consensus sequence-binding protein; IRF-8
Orthologs:
Mus musculus (house mouse) : Irf8 (interferon regulatory factor 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf8 (interferon regulatory factor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf8 (interferon regulatory factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF8 (interferon regulatory factor 8)
Canis lupus familiaris (dog) : IRF8 (interferon regulatory factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf8 (interferon regulatory factor 8)
Sus scrofa (pig) : IRF8 (interferon regulatory factor 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,899,162 - 85,922,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371685,932,774 - 85,956,212 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361684,490,275 - 84,513,713 (+)NCBINCBI36hg18NCBI36
Build 341684,490,274 - 84,513,710NCBI
Celera1670,235,758 - 70,259,207 (+)NCBI
Cytogenetic Map16q24.1NCBI
HuRef1671,673,680 - 71,697,160 (+)NCBIHuRef
CHM1_11687,344,316 - 87,367,790 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on IRF8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351360
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.