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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzaldehydes
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Accession:CHEBI:22698 term browser browse the term
Definition:Any arenecarbaldehyde that consists of a formyl substituted benzene ring and its substituted derivatives thereof.
Synonyms:xref_mesh: MESH:D001547


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benzaldehydes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 decreases activity EXP Benzaldehydes results in decreased activity of ALDH1A2 protein CTD PMID:22079344 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member decreases activity EXP Benzaldehydes results in decreased activity of ALDH2 protein CTD PMID:22079344 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
2,5-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member increases metabolic processing EXP ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
2-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR7A2 aldo-keto reductase family 7 member A2 increases reduction
affects reduction		 EXP
ISO		 AKR7A2 protein results in increased reduction of 2-nitrobenzaldehyde
2-nitrobenzaldehyde affects the reduction of AKR7A5 protein		 CTD PMID:10510318 PMID:12604212 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144 		JBrowse link
3,4-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions EXP protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of ACHE protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein] CTD PMID:29665407 PMID:29732668 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:25582705 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions EXP
ISO		 protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]		 CTD PMID:17597607 PMID:25582705 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G CAT catalase multiple interactions
increases activity		 EXP protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
protocatechualdehyde results in increased activity of CAT protein		 CTD PMID:29665407 PMID:29732668 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CDH1 cadherin 1 multiple interactions EXP protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:25582705 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP
ISO		 protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein]		 CTD PMID:25582705 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions EXP protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of G6PD protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein] CTD PMID:29665407 PMID:29732668 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GLO1 glyoxalase I multiple interactions EXP protocatechualdehyde inhibits the reaction [sodium arsenite results in increased activity of GLO1 protein] CTD PMID:29732668 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:29665407 PMID:29732668 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO
EXP		 protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]		 CTD PMID:25582705 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G S100B S100 calcium binding protein B multiple interactions EXP protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208 		JBrowse link
G SMAD2 SMAD family member 2 multiple interactions EXP protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:17597607 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 multiple interactions EXP protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP protocatechualdehyde inhibits the reaction [Potassium Dichromate results in increased activity of SOD1 protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein] CTD PMID:29665407 PMID:29732668 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:17597607 PMID:25582705 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G VIM vimentin multiple interactions EXP protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:25582705 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
3,5-di-tert-Butyl-4-hydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of ESR1 protein CTD PMID:27633901 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions EXP 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G PGR progesterone receptor multiple interactions EXP 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of THRB protein CTD PMID:27633901 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
3-hydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member increases metabolic processing EXP ALDH2 protein results in increased metabolism of 3-hydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
4-(diethylamino)benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 decreases activity
multiple interactions
increases oxidation		 ISO
EXP		 4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein
4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide]
ALDH1A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde		 CTD PMID:8662658 PMID:16316642 PMID:25512087 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 multiple interactions EXP 4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH1A2 protein CTD PMID:25512087 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member multiple interactions EXP 4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH2 protein CTD PMID:25512087 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 increases oxidation EXP ALDH3A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde CTD PMID:25512087 NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943 		JBrowse link
4-formylbenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 increases reduction EXP AKR1A1 protein results in increased reduction of 4-carboxybenzaladehyde CTD PMID:10510318 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
4-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 increases reduction EXP AKR1A1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases reduction EXP AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 increases metabolic processing EXP AKR1B15 protein results in increased metabolism of 4-nitrobenzaldehyde CTD PMID:21276782 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 multiple interactions
affects reduction		 ISO Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Indomethacin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Quercetin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Valproic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein] CTD PMID:12604212 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144 		JBrowse link
G DHRS7 dehydrogenase/reductase 7 increases reduction EXP DHRS7 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:24246760 NCBI chr14:60,144,119...60,169,889
Ensembl chr14:60,144,119...60,169,856 		JBrowse link
G DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 multiple interactions EXP [Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein CTD PMID:33617879 NCBI chr12:67,648,745...67,665,406
Ensembl chr12:67,648,338...67,665,406 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 4-nitrobenzaldehyde] CTD PMID:20932822 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases oxidation
increases metabolic processing		 ISO ALDH1A1 protein results in increased oxidation of benzaldehyde
ALDH1A1 protein results in increased metabolism of benzaldehyde		 CTD PMID:10998257 PMID:21256123 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member increases metabolic processing
multiple interactions		 EXP ALDH2 protein results in increased metabolism of benzaldehyde
benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]		 CTD PMID:10609638 PMID:11744614 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 multiple interactions
increases oxidation
increases metabolic processing		 EXP
ISO		 [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
ALDH3A1 protein results in increased metabolism of benzaldehyde		 CTD PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087 NCBI chr17:19,737,984...19,748,298
Ensembl chr17:19,737,984...19,748,943 		JBrowse link
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 affects binding EXP benzaldehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr11:68,008,547...68,029,276
Ensembl chr11:68,008,578...68,029,282 		JBrowse link
G AR androgen receptor multiple interactions ISO benzaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases chemical synthesis
decreases activity
multiple interactions		 EXP CYP2A6 protein results in increased chemical synthesis of benzaldehyde
benzaldehyde results in decreased activity of CYP2A6 protein
[[benzaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [benzaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin		 CTD PMID:10616189 PMID:32496054 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G OR8A1 olfactory receptor family 8 subfamily A member 1 multiple interactions ISO benzaldehyde binds to and results in increased activity of OR8A1 protein CTD PMID:11943806 NCBI chr11:124,569,997...124,571,374
Ensembl chr11:124,566,660...124,582,942 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases activity
multiple interactions		 ISO benzaldehyde results in increased activity of SLC2A1 protein
[benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein		 CTD PMID:20955755 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
decreases activity		 EXP [[ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G OR5D18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO [ethyl vanillin binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OR5D18 protein CTD PMID:15716417 NCBI chr11:55,819,630...55,820,571
Ensembl chr11:55,819,630...55,820,571 		JBrowse link
G TRPV3 transient receptor potential cation channel subfamily V member 3 increases activity ISO ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr17:3,510,502...3,557,812
Ensembl chr17:3,510,502...3,557,812 		JBrowse link
m-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity ISO 3-methylbenzaldehyde results in decreased activity of CYP2E1 protein CTD PMID:12791539 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP4B1 cytochrome P450 family 4 subfamily B member 1 affects activity ISO 3-methylbenzaldehyde affects the activity of CYP4B1 protein CTD PMID:12791539 NCBI chr 1:46,799,046...46,819,413
Ensembl chr 1:46,757,838...46,819,413 		JBrowse link
ortho-vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
p-methoxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPA1 transient receptor potential cation channel subfamily A member 1 increases activity EXP 4-anisaldehyde results in increased activity of TRPA1 protein CTD PMID:21591660 NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584 		JBrowse link
p-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of AHR protein CTD PMID:27633901 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AR androgen receptor multiple interactions EXP 4-methylbenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP 4-methylbenzaldehyde binds to and results in decreased activity of ESR2 protein CTD PMID:27633901 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IL1B protein] CTD PMID:27569861 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:27569861 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27569861 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27569861 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:27569861 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:27569861 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27569861 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PGR progesterone receptor multiple interactions EXP 4-methylbenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 4-methylbenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:27569861 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:27569861 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:27569861 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
phthalaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase affects expression ISO o-Phthalaldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 affects expression ISO o-Phthalaldehyde affects the expression of AKR1C18 mRNA CTD PMID:22302311 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G CCL15 C-C motif chemokine ligand 15 affects expression ISO o-Phthalaldehyde affects the expression of CCL6 mRNA CTD PMID:22302311 NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553 		JBrowse link
G CCNA2 cyclin A2 affects expression ISO o-Phthalaldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 affects expression ISO o-Phthalaldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCNE2 cyclin E2 affects expression ISO o-Phthalaldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CCR4 C-C motif chemokine receptor 4 affects expression ISO o-Phthalaldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 3:32,951,644...32,956,349
Ensembl chr 3:32,951,644...32,956,349 		JBrowse link
G CD207 CD207 molecule affects expression ISO o-Phthalaldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 2:70,824,130...70,835,816
Ensembl chr 2:70,830,211...70,835,816 		JBrowse link
G CD5L CD5 molecule like affects expression ISO o-Phthalaldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 1:157,827,068...157,841,808
Ensembl chr 1:157,830,911...157,898,256 		JBrowse link
G CD83 CD83 molecule affects expression ISO o-Phthalaldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918 		JBrowse link
G CDC20 cell division cycle 20 affects expression ISO o-Phthalaldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203 		JBrowse link
G CDC25C cell division cycle 25C affects expression ISO o-Phthalaldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355 		JBrowse link
G CDK1 cyclin dependent kinase 1 affects expression ISO o-Phthalaldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CLEC7A C-type lectin domain containing 7A affects expression ISO o-Phthalaldehyde affects the expression of CLEC7A mRNA CTD PMID:22302311 NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258 		JBrowse link
G COL8A1 collagen type VIII alpha 1 chain affects expression ISO o-Phthalaldehyde affects the expression of COL8A1 mRNA CTD PMID:22302311 NCBI chr 3:99,638,594...99,799,217
Ensembl chr 3:99,638,475...99,799,226 		JBrowse link
G CPHXL2 cytoplasmic polyadenylated homeobox like 2 affects expression ISO o-Phthalaldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr16:75,660,227...75,677,009
Ensembl chr16:75,660,227...75,677,009
Ensembl chr16:75,660,227...75,677,009 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 affects expression ISO o-Phthalaldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression ISO o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA CTD PMID:20112102 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression ISO o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA CTD PMID:20112102 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DIO1 iodothyronine deiodinase 1 decreases activity EXP o-Phthalaldehyde results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086 		JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases activity EXP o-Phthalaldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757 		JBrowse link
G DIO3 iodothyronine deiodinase 3 decreases activity EXP o-Phthalaldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452 		JBrowse link
G E2F1 E2F transcription factor 1 affects expression ISO o-Phthalaldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G FABP7 fatty acid binding protein 7 affects expression ISO o-Phthalaldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr 6:122,749,201...122,784,074
Ensembl chr 6:122,779,716...122,784,074 		JBrowse link
G FXYD4 FXYD domain containing ion transport regulator 4 affects expression ISO o-Phthalaldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr10:43,371,636...43,376,335
Ensembl chr10:43,371,636...43,376,335 		JBrowse link
G GZMB granzyme B affects expression ISO o-Phthalaldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267 		JBrowse link
G IFNG interferon gamma increases expression ISO o-Phthalaldehyde results in increased expression of IFNG mRNA CTD PMID:21785612 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 increases expression ISO o-Phthalaldehyde results in increased expression of IL10 mRNA CTD PMID:21785612 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B affects expression ISO o-Phthalaldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL13 interleukin 13 increases expression ISO o-Phthalaldehyde results in increased expression of IL13 mRNA CTD PMID:21785612 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL1B interleukin 1 beta increases expression ISO o-Phthalaldehyde results in increased expression of IL1B mRNA CTD PMID:21785612 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL21 interleukin 21 affects expression ISO o-Phthalaldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha affects expression ISO o-Phthalaldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370 		JBrowse link
G IL4 interleukin 4 affects expression
increases expression		 ISO o-Phthalaldehyde affects the expression of IL4 mRNA
o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein		 CTD PMID:19110043 PMID:20176622 PMID:21785612 PMID:22302311 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 increases expression ISO o-Phthalaldehyde results in increased expression of IL5 mRNA CTD PMID:19110043 PMID:21785612 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G ITGAV integrin subunit alpha V affects expression ISO o-Phthalaldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901 		JBrowse link
G IYD iodotyrosine deiodinase multiple interactions EXP o-Phthalaldehyde inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 6:150,369,012...150,405,969
Ensembl chr 6:150,368,892...150,405,969 		JBrowse link
G LGALS7 galectin 7 affects expression ISO o-Phthalaldehyde affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr19:38,770,968...38,773,517
Ensembl chr19:38,789,200...38,791,754
Ensembl chr19:38,789,200...38,791,754 		JBrowse link
G MKI67 marker of proliferation Ki-67 affects expression ISO o-Phthalaldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G NTS neurotensin affects expression ISO o-Phthalaldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992 		JBrowse link
G THBS1 thrombospondin 1 affects expression ISO o-Phthalaldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466 		JBrowse link
G THBS4 thrombospondin 4 affects expression ISO o-Phthalaldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 affects expression ISO o-Phthalaldehyde affects the expression of TIMP1 mRNA CTD PMID:22302311 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TNF tumor necrosis factor increases expression ISO o-Phthalaldehyde results in increased expression of TNF mRNA CTD PMID:21785612 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 affects activity EXP o-Phthalaldehyde affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TRPM6 transient receptor potential cation channel subfamily M member 6 affects expression ISO o-Phthalaldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr 9:74,722,495...74,887,921
Ensembl chr 9:74,722,495...74,888,094 		JBrowse link
vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein] CTD PMID:33823243 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP vanillin results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G CA1 carbonic anhydrase 1 decreases activity EXP vanillin results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014 		JBrowse link
G CA2 carbonic anhydrase 2 decreases activity EXP vanillin results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; vanillin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein] CTD PMID:29216766 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO
EXP		 vanillin inhibits the reaction [potassium bromate results in increased activity of CAT protein]
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]		 CTD PMID:26296324 PMID:33823243 PMID:37336463 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] CTD PMID:36416909 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCN2 cellular communication network factor 2 decreases expression EXP vanillin results in decreased expression of CCN2 mRNA CTD PMID:17178418 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CLK2 CDC like kinase 2 increases expression EXP vanillin results in increased expression of CLK2 mRNA CTD PMID:17178418 NCBI chr 1:155,262,868...155,273,504
Ensembl chr 1:155,262,868...155,278,491 		JBrowse link
G CST3 cystatin C multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of CST3 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of CST3 protein] CTD PMID:29216766 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions		 EXP vanillin results in increased expression of CXCL8 mRNA
vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]		 CTD PMID:20491607 PMID:21920952 PMID:36416909 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP vanillin results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
decreases activity		 EXP [[vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression EXP vanillin results in increased expression of DDIT4 mRNA CTD PMID:17178418 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP vanillin results in decreased expression of DNMT3B mRNA CTD PMID:17178418 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G DUSP6 dual specificity phosphatase 6 decreases expression EXP vanillin results in decreased expression of DUSP6 mRNA CTD PMID:17178418 NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501 		JBrowse link
G FASLG Fas ligand multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of FASLG protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of FASLG protein] CTD PMID:29216766 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FBP1 fructose-bisphosphatase 1 affects binding EXP vanillin binds to FBP1 protein CTD PMID:33823243 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression EXP vanillin results in decreased expression of FGFR2 mRNA CTD PMID:17178418 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G FZD2 frizzled class receptor 2 decreases expression EXP vanillin results in decreased expression of FZD2 mRNA CTD PMID:17178418 NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 affects binding EXP vanillin binds to G6PC1 protein CTD PMID:33823243 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions EXP vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:37336463 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GAPDH protein] CTD PMID:37336463 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP vanillin results in increased expression of GCLM mRNA CTD PMID:17178418 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GLO1 glyoxalase I multiple interactions EXP vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GLO1 protein] CTD PMID:37336463 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:37336463 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP vanillin results in increased expression of HMOX1 mRNA CTD PMID:17178418 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 decreases mutagenesis EXP vanillin results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B increases expression EXP vanillin results in increased expression of HSPA1B mRNA CTD PMID:17178418 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP vanillin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of IL18 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of IL18 protein] CTD PMID:29216766 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of IL1B mRNA] CTD PMID:26296324 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of IL6 mRNA] CTD PMID:26296324 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INSIG1 insulin induced gene 1 decreases expression EXP vanillin results in decreased expression of INSIG1 mRNA CTD PMID:17178418 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP vanillin results in decreased expression of JUND mRNA CTD PMID:17178418 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G LCN2 lipocalin 2 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of LCN2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of LCN2 protein] CTD PMID:29216766 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 decreases expression EXP vanillin results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MARK4 microtubule affinity regulating kinase 4 decreases expression EXP vanillin results in decreased expression of MARK4 mRNA CTD PMID:17178418 NCBI chr19:45,251,271...45,305,284
Ensembl chr19:45,079,288...45,305,284 		JBrowse link
G MT1X metallothionein 1X multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of MT1 mRNA] CTD PMID:27074584 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196 		JBrowse link
G MT2A metallothionein 2A increases expression
multiple interactions		 EXP
ISO		 vanillin results in increased expression of MT2A mRNA
vanillin inhibits the reaction [potassium bromate results in increased expression of MT2 mRNA]		 CTD PMID:20491607 PMID:27074584 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] CTD PMID:29216766 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PPP1R10 protein phosphatase 1 regulatory subunit 10 decreases expression EXP vanillin results in decreased expression of PPP1R10 mRNA CTD PMID:17178418 NCBI chr 6:30,600,413...30,617,243
Ensembl chr 6:30,600,413...30,618,612 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO vanillin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; vanillin inhibits the reaction [potassium bromate results in increased expression of PTGS2 mRNA] CTD PMID:17465205 PMID:26296324 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PYGL glycogen phosphorylase L affects binding EXP vanillin binds to PYGL protein CTD PMID:33823243 NCBI chr14:50,905,217...50,944,483
Ensembl chr14:50,857,891...50,944,483 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of RELA protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of RELA protein] CTD PMID:29216766 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC35D2 solute carrier family 35 member D2 decreases expression EXP vanillin results in decreased expression of SLC35D2 mRNA CTD PMID:17178418 NCBI chr 9:96,313,444...96,383,711
Ensembl chr 9:96,313,444...96,383,711 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP vanillin results in increased expression of SLC7A11 mRNA CTD PMID:17178418 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G TGFB1I1 transforming growth factor beta 1 induced transcript 1 decreases expression EXP vanillin results in decreased expression of TGFB1I1 mRNA CTD PMID:17178418 NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 vanillin inhibits the reaction [potassium bromate results in increased expression of TNF mRNA]
vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
vanillin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of TNF protein]		 CTD PMID:26296324 PMID:29216766 PMID:36416909 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 decreases expression EXP vanillin results in decreased expression of TP53 mRNA CTD PMID:17178418 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TRIM16 tripartite motif containing 16 increases expression EXP vanillin results in increased expression of TRIM16 mRNA CTD PMID:17178418 NCBI chr17:15,627,966...15,684,311
Ensembl chr17:15,627,960...15,684,311 		JBrowse link
G TRPV3 transient receptor potential cation channel subfamily V member 3 increases activity ISO vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr17:3,510,502...3,557,812
Ensembl chr17:3,510,502...3,557,812 		JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 increases expression EXP vanillin results in increased expression of UGP2 mRNA CTD PMID:17178418 NCBI chr 2:63,840,969...63,891,560
Ensembl chr 2:63,840,952...63,891,562 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    role 25966
      application 25188
        solvent 18747
          formic acid 10011
            formyl group 9973
              aldehyde 9973
                arenecarbaldehyde 144
                  benzaldehydes 139
                    10-epi-pyriculol 0
                    2',4',6'-trihydroxy-3'-formyldihydrochalcone 0
                    2-formylbenzoic acid 0
                    2-formylphenylformamide + 0
                    2-nitrobenzaldehyde 1
                    3-Acetyl-6-methoxybenzaldehyde 0
                    3-O-acetyl-4'-O-demethylpapaveroxine + 0
                    3-O-acetylpapaveroxine 0
                    3-allyl-2-[2-(diethylamino)ethoxy]benzaldehyde 0
                    3-bromo-4-(dimethylamino)benzaldehyde 0
                    3-fluorobenzaldehyde 0
                    3-methoxybenzaldehyde 0
                    3-methylsalicylaldehyde 0
                    4-(diethylamino)benzaldehyde 4
                    4-(dimethylamino)benzaldehyde 0
                    4-(trifluoromethyl)benzaldehyde 0
                    4-acetoxy benzaldehyde 0
                    4-chlorobenzaldehyde 0
                    4-cyanobenzaldehyde 0
                    4-formyl-2-methoxyphenyl L-menthyl glutarate 0
                    4-formylbenzoic acid 1
                    4-hydroxymethylsalicylaldehyde 0
                    4-nitrobenzaldehyde 7
                    5-aminosalicylaldehyde 0
                    5-formylsalicylic acid 0
                    5-methoxysalicylaldehyde 0
                    5-nitrovanillin + 0
                    Eutypine 0
                    TAN-931 0
                    benzaldehyde 8
                    cuminaldehyde 0
                    dihydroxybenzaldehyde + 17
                    ethyl vanillin 3
                    ethyl vanillin isobutyrate 0
                    eucalyptal A 0
                    eucalyptal B 0
                    eucalyptal C 0
                    helicin 0
                    hydroxybenzaldehyde + 11
                    ilicicolin B 0
                    isotetrahydroauroglaucin 0
                    isovanillin 0
                    ortho-vanillin 4
                    p-aminobenzaldehyde 0
                    p-methoxybenzaldehyde 1
                    phthalaldehyde 46
                    pyriculariol 0
                    pyriculol + 0
                    syringaldehyde acetate 0
                    tolualdehyde + 17
                    vanillin + 59
                    vanillin acetate 0
                    veratraldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            heteroorganic entity 24782
                              organochalcogen compound 24395
                                organooxygen compound 24072
                                  carbon oxoacid 22773
                                    carboxylic acid 22753
                                      carboacyl group 20068
                                        univalent carboacyl group 20068
                                          formyl group 9973
                                            aldehyde 9973
                                              arenecarbaldehyde 144
                                                benzaldehydes 139
                                                  10-epi-pyriculol 0
                                                  2',4',6'-trihydroxy-3'-formyldihydrochalcone 0
                                                  2-formylbenzoic acid 0
                                                  2-formylphenylformamide + 0
                                                  2-nitrobenzaldehyde 1
                                                  3-Acetyl-6-methoxybenzaldehyde 0
                                                  3-O-acetyl-4'-O-demethylpapaveroxine + 0
                                                  3-O-acetylpapaveroxine 0
                                                  3-allyl-2-[2-(diethylamino)ethoxy]benzaldehyde 0
                                                  3-bromo-4-(dimethylamino)benzaldehyde 0
                                                  3-fluorobenzaldehyde 0
                                                  3-methoxybenzaldehyde 0
                                                  3-methylsalicylaldehyde 0
                                                  4-(diethylamino)benzaldehyde 4
                                                  4-(dimethylamino)benzaldehyde 0
                                                  4-(trifluoromethyl)benzaldehyde 0
                                                  4-acetoxy benzaldehyde 0
                                                  4-chlorobenzaldehyde 0
                                                  4-cyanobenzaldehyde 0
                                                  4-formyl-2-methoxyphenyl L-menthyl glutarate 0
                                                  4-formylbenzoic acid 1
                                                  4-hydroxymethylsalicylaldehyde 0
                                                  4-nitrobenzaldehyde 7
                                                  5-aminosalicylaldehyde 0
                                                  5-formylsalicylic acid 0
                                                  5-methoxysalicylaldehyde 0
                                                  5-nitrovanillin + 0
                                                  Eutypine 0
                                                  TAN-931 0
                                                  benzaldehyde 8
                                                  cuminaldehyde 0
                                                  dihydroxybenzaldehyde + 17
                                                  ethyl vanillin 3
                                                  ethyl vanillin isobutyrate 0
                                                  eucalyptal A 0
                                                  eucalyptal B 0
                                                  eucalyptal C 0
                                                  helicin 0
                                                  hydroxybenzaldehyde + 11
                                                  ilicicolin B 0
                                                  isotetrahydroauroglaucin 0
                                                  isovanillin 0
                                                  ortho-vanillin 4
                                                  p-aminobenzaldehyde 0
                                                  p-methoxybenzaldehyde 1
                                                  phthalaldehyde 46
                                                  pyriculariol 0
                                                  pyriculol + 0
                                                  syringaldehyde acetate 0
                                                  tolualdehyde + 17
                                                  vanillin + 59
                                                  vanillin acetate 0
                                                  veratraldehyde 0
paths to the root