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Gene: DIO1 (iodothyronine deiodinase 1) Homo sapiens
Symbol: DIO1
Name: iodothyronine deiodinase 1
Description: Predicted to have thyroxine 5'-deiodinase activity. Predicted to be involved in thyroid hormone metabolic process. Predicted to localize to the plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DI; deiodinase, iodothyronine type I; deiodinase, iodothyronine, type I; DIOI; iodothyronine deiodinase type 1; MGC130050; MGC130051; thyroxine 5'-deiodinase; thyroxine deiodinase type I (selenoprotein); TXDI1; type 1 DI; type I iodothyronine deiodinase; type-I 5'-deiodinase; type-I 5'deiodinase
Mus musculus (house mouse) : Dio1 (deiodinase, iodothyronine, type I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dio1 (iodothyronine deiodinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio1 (iodothyronine deiodinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO1 (iodothyronine deiodinase 1)
Canis lupus familiaris (dog) : DIO1 (iodothyronine deiodinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio1 (iodothyronine deiodinase 1)
Sus scrofa (pig) : DIO1 (iodothyronine deiodinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38153,894,187 - 53,911,086 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37154,359,860 - 54,376,763 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36154,132,449 - 54,149,347 (+)NCBINCBI36hg18NCBI36
Build 34154,071,881 - 54,088,779NCBI
Celera152,647,532 - 52,664,449 (+)NCBI
Cytogenetic Map1p32.3NCBI
HuRef152,475,576 - 52,492,483 (+)NCBIHuRef
CHM1_1154,476,232 - 54,493,132 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DIO1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735269
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.