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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vanillin
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Accession:CHEBI:18346 term browser browse the term
Definition:A member of the class of benzaldehydes carrying methoxy and hydroxy substituents at positions 3 and 4 respectively.
Synonyms:related_synonym: 3-methoxy-4-hydroxybenzaldehyde;   4-Hydroxy-3-methoxy-benzaldehyde;   4-Hydroxy-3-methoxybenzaldehyde;   4-formyl-2-methoxyphenol;   4-hydroxy-m-anisaldehyde;   Formula=C8H8O3;   InChI=1S/C8H8O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-5,10H,1H3;   InChIKey=MWOOGOJBHIARFG-UHFFFAOYSA-N;   SMILES=[H]C(=O)C1=CC(OC)=C(O)C=C1;   Vanillaldehyde;   methylprotocatechuic aldehyde;   p-hydroxy-m-methoxybenzaldehyde;   p-vanillin;   vaniline;   vanillic aldehyde
 alt_id: CHEBI:15302;   CHEBI:1842;   CHEBI:20380;   CHEBI:48387
 xref: Beilstein:472792;   CAS:121-33-5;   FooDB:FDB000838;   Gmelin:3596;   HMDB:HMDB0012308;   KEGG:C00755;   KEGG:D00091;   KNApSAcK:C00002683;   KNApSAcK:C00029531
 xref_mesh: MESH:C100058
 xref: MetaCyc:VANILLIN;   PDBeChem:V55;   PMCID:PMC7790484;   PMCID:PMC8235570;   PMID:18479250;   PMID:19238838;   PMID:19812218;   PMID:21417387;   PMID:21542597;   PMID:21846089;   PMID:22308371;   PMID:29950589;   PMID:31661600;   PMID:33477040;   PMID:33938405;   PMID:34013088;   PMID:34035660;   UM-BBD_compID:c0193;   Wikipedia:Vanillin



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vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO vanillin results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO vanillin results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO vanillin results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Cat catalase multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased activity of CAT protein] CTD PMID:26296324 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO vanillin results in decreased expression of CCN2 mRNA CTD PMID:17178418 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Clk2 CDC-like kinase 2 increases expression ISO vanillin results in increased expression of CLK2 mRNA CTD PMID:17178418 NCBI chr 2:174,570,614...174,582,645 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO vanillin results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO vanillin results in increased expression of DDIT4 mRNA CTD PMID:17178418 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO vanillin results in decreased expression of DNMT3B mRNA CTD PMID:17178418 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO vanillin results in decreased expression of DUSP6 mRNA CTD PMID:17178418 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO vanillin results in decreased expression of FGFR2 mRNA CTD PMID:17178418 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO vanillin results in decreased expression of FZD2 mRNA CTD PMID:17178418 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO vanillin results in increased expression of GCLM mRNA CTD PMID:17178418 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO vanillin results in increased expression of HMOX1 mRNA CTD PMID:17178418 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases mutagenesis ISO vanillin results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO vanillin results in increased expression of HSPA1B mRNA CTD PMID:17178418 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of IL1B mRNA] CTD PMID:26296324 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of IL6 mRNA] CTD PMID:26296324 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO vanillin results in decreased expression of INSIG1 mRNA CTD PMID:17178418 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO vanillin results in decreased expression of JUND mRNA CTD PMID:17178418 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO vanillin results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mark4 microtubule affinity regulating kinase 4 decreases expression ISO vanillin results in decreased expression of MARK4 mRNA CTD PMID:17178418 NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of MT1 mRNA] CTD PMID:27074584 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A increases expression
multiple interactions
ISO vanillin results in increased expression of MT2A mRNA
vanillin inhibits the reaction [potassium bromate results in increased expression of MT2 mRNA]
CTD PMID:20491607 PMID:27074584 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO vanillin results in decreased expression of PPP1R10 mRNA CTD PMID:17178418 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO vanillin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; vanillin inhibits the reaction [potassium bromate results in increased expression of PTGS2 mRNA] CTD PMID:17465205 PMID:26296324 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc35d2 solute carrier family 35 member D2 decreases expression ISO vanillin results in decreased expression of SLC35D2 mRNA CTD PMID:17178418 NCBI chr17:987,899...1,019,747
Ensembl chr17:988,157...1,019,743
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO vanillin results in increased expression of SLC7A11 mRNA CTD PMID:17178418 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 decreases expression ISO vanillin results in decreased expression of TGFB1I1 mRNA CTD PMID:17178418 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of TNF mRNA] CTD PMID:26296324 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO vanillin results in decreased expression of TP53 mRNA CTD PMID:17178418 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO vanillin results in increased expression of TRIM16 mRNA CTD PMID:17178418 NCBI chr10:47,485,982...47,509,010 JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO vanillin results in increased expression of UGP2 mRNA CTD PMID:17178418 NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 9:88,727,094...88,808,465 JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC686683 similar to olfactory receptor 73 multiple interactions ISO [ethyl vanillin binds to and results in increased activity of OLFR73 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OLFR73 protein CTD PMID:15716417 NCBI chr 3:73,516,522...73,517,463 JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      chemical role 19330
        antioxidant 14450
          vanillin 38
            5-nitrovanillin + 0
            ethyl vanillin 2
            vanillin acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        carboacyl group 17487
                                          univalent carboacyl group 17487
                                            formyl group 8799
                                              aldehyde 8799
                                                arenecarbaldehyde 128
                                                  benzaldehydes 125
                                                    vanillin 38
                                                      5-nitrovanillin + 0
                                                      ethyl vanillin 2
                                                      vanillin acetate 0
paths to the root