DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) - Rat Genome Database

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Gene: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) Homo sapiens
Analyze
Symbol: DYRK2
Name: dual specificity tyrosine phosphorylation regulated kinase 2
RGD ID: 1323814
HGNC Page HGNC:3093
Description: Enables ion binding activity and protein kinase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and positive regulation of glycogen biosynthetic process. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; FLJ21217; FLJ21365
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381267,648,745 - 67,665,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1267,648,338 - 67,665,406 (+)EnsemblGRCh38hg38GRCh38
GRCh371268,042,525 - 68,059,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,328,779 - 66,342,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 341266,329,020 - 66,340,410NCBI
Celera1267,706,515 - 67,720,446 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,093,416 - 65,107,347 (+)NCBIHuRef
CHM1_11268,010,112 - 68,024,043 (+)NCBICHM1_1
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2-methylcholine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nitrobenzaldehyde  (EXP)
5-iodotubercidin  (EXP)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (EXP)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
DDT  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
endosulfan  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
hexestrol  (EXP)
indometacin  (EXP)
inulin  (ISO)
irinotecan  (EXP,ISO)
maneb  (ISO)
menadione  (EXP)
mestranol  (EXP)
methapyrilene  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (EXP)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP)
mitoxantrone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
pyrazinecarboxamide  (ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
Soman  (ISO)
tetrachloromethane  (ISO)
troglitazone  (ISO)
urethane  (EXP)
valproic acid  (EXP)
valsartan  (EXP)
vinclozolin  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9748265   PMID:11311121   PMID:12477932   PMID:12588975   PMID:14593110   PMID:15146197   PMID:15489334   PMID:16189514   PMID:16344560   PMID:16511445   PMID:17349958   PMID:18029348  
PMID:18455992   PMID:19287380   PMID:19596956   PMID:19818968   PMID:19965871   PMID:21244100   PMID:21832049   PMID:21873635   PMID:22307329   PMID:22878263   PMID:22939624   PMID:23362280  
PMID:23602568   PMID:23791882   PMID:24162774   PMID:24438055   PMID:25095982   PMID:25416956   PMID:25712377   PMID:26341817   PMID:26407194   PMID:26804244   PMID:27173435   PMID:27532268  
PMID:27721402   PMID:27721409   PMID:27746162   PMID:28194753   PMID:28242748   PMID:28502078   PMID:28514442   PMID:28677030   PMID:29193658   PMID:29507117   PMID:29513927   PMID:29724823  
PMID:30590706   PMID:30851422   PMID:30862715   PMID:31209060   PMID:31505048   PMID:31815665   PMID:32236621   PMID:32707033   PMID:33368138   PMID:33376136   PMID:33961781   PMID:34373451  
PMID:35347031   PMID:35439114   PMID:35559673   PMID:36622366   PMID:36736316   PMID:36931259   PMID:36934104  


Genomics

Comparative Map Data
DYRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381267,648,745 - 67,665,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1267,648,338 - 67,665,406 (+)EnsemblGRCh38hg38GRCh38
GRCh371268,042,525 - 68,059,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,328,779 - 66,342,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 341266,329,020 - 66,340,410NCBI
Celera1267,706,515 - 67,720,446 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,093,416 - 65,107,347 (+)NCBIHuRef
CHM1_11268,010,112 - 68,024,043 (+)NCBICHM1_1
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBIT2T-CHM13v2.0
Dyrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,691,507 - 118,725,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,691,508 - 118,706,114 (-)EnsemblGRCm39 Ensembl
GRCm3810118,855,602 - 118,889,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,855,603 - 118,870,209 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710118,296,405 - 118,305,959 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610118,262,342 - 118,271,896 (-)NCBIMGSCv36mm8
Celera10121,236,125 - 121,244,887 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
Dyrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,235,276 - 56,265,741 (-)NCBIGRCr8
mRatBN7.2754,348,724 - 54,381,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,349,610 - 54,380,106 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx756,256,148 - 56,268,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,459,275 - 58,471,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,237,109 - 58,249,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,785,423 - 61,816,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,786,309 - 61,798,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,775,902 - 61,807,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4758,114,127 - 58,126,547 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1758,138,697 - 58,149,260 (-)NCBI
Celera751,116,337 - 51,128,757 (-)NCBICelera
Cytogenetic Map7q22NCBI
Dyrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,193,303 - 14,218,957 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,199,912 - 14,201,712 (+)NCBIChiLan1.0ChiLan1.0
DYRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21026,689,217 - 26,704,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11226,685,982 - 26,701,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01221,241,325 - 21,260,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,751,119 - 21,766,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,757,436 - 21,767,505 (-)Ensemblpanpan1.1panPan2
DYRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1109,982,245 - 9,994,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl109,980,080 - 9,991,934 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha109,915,768 - 9,929,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,099,203 - 10,112,645 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,098,813 - 10,108,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1109,974,467 - 9,987,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,221,581 - 10,234,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,343,266 - 10,356,687 (+)NCBIUU_Cfam_GSD_1.0
Dyrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494548,553,639 - 48,567,246 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365455,542,803 - 5,554,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365455,542,873 - 5,555,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,047,643 - 32,064,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,047,614 - 32,064,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,120,816 - 110,124,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,294,035 - 63,308,008 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,294,444 - 63,304,080 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dyrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624802650,119 - 660,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624802643,783 - 660,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DYRK2
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q14.2-15(chr12:64368308-69123358)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052815]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052815]|See cases [RCV000052815] Chr12:64368308..69123358 [GRCh38]
Chr12:64762088..69517138 [GRCh37]
Chr12:63048355..67803405 [NCBI36]
Chr12:12q14.2-15
pathogenic
GRCh38/hg38 12q14.3-15(chr12:65958499-69057308)x1 copy number loss See cases [RCV000052816] Chr12:65958499..69057308 [GRCh38]
Chr12:66352279..69451088 [GRCh37]
Chr12:64638546..67737355 [NCBI36]
Chr12:12q14.3-15
pathogenic|likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q14.3-15(chr12:65445176-71026337)x1 copy number loss See cases [RCV000142445] Chr12:65445176..71026337 [GRCh38]
Chr12:65838956..71420117 [GRCh37]
Chr12:64125223..69706384 [NCBI36]
Chr12:12q14.3-15
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q14.1-15(chr12:59495114-70574966)x1 copy number loss See cases [RCV000447164] Chr12:59495114..70574966 [GRCh37]
Chr12:12q14.1-15
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_006482.3(DYRK2):c.33C>T (p.Pro11=) single nucleotide variant not provided [RCV000973496] Chr12:67649166 [GRCh38]
Chr12:68042946 [GRCh37]
Chr12:12q15
benign
NM_006482.3(DYRK2):c.386G>A (p.Ser129Asn) single nucleotide variant Inborn genetic diseases [RCV003247963] Chr12:67657293 [GRCh38]
Chr12:68051073 [GRCh37]
Chr12:12q15
uncertain significance
GRCh37/hg19 12q14.3-21.1(chr12:65251705-75263379)x1 copy number loss not provided [RCV001537907] Chr12:65251705..75263379 [GRCh37]
Chr12:12q14.3-21.1
pathogenic
GRCh37/hg19 12q14.3-15(chr12:66045645-68872343)x1 copy number loss not provided [RCV001832934] Chr12:66045645..68872343 [GRCh37]
Chr12:12q14.3-15
pathogenic
GRCh37/hg19 12q14.2-15(chr12:64609458-70352103)x1 copy number loss not provided [RCV002511748] Chr12:64609458..70352103 [GRCh37]
Chr12:12q14.2-15
pathogenic
NM_006482.3(DYRK2):c.616G>A (p.Asp206Asn) single nucleotide variant Inborn genetic diseases [RCV002771928] Chr12:67657523 [GRCh38]
Chr12:68051303 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.599A>G (p.Asn200Ser) single nucleotide variant Inborn genetic diseases [RCV002685233] Chr12:67657506 [GRCh38]
Chr12:68051286 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1362T>G (p.Asn454Lys) single nucleotide variant Inborn genetic diseases [RCV002859940] Chr12:67658269 [GRCh38]
Chr12:68052049 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.197C>A (p.Thr66Lys) single nucleotide variant Inborn genetic diseases [RCV002859232] Chr12:67649944 [GRCh38]
Chr12:68043724 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1325C>T (p.Ser442Leu) single nucleotide variant Inborn genetic diseases [RCV002732580] Chr12:67658232 [GRCh38]
Chr12:68052012 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1441C>T (p.Arg481Cys) single nucleotide variant Inborn genetic diseases [RCV002882845] Chr12:67658348 [GRCh38]
Chr12:68052128 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.176A>G (p.Asn59Ser) single nucleotide variant Inborn genetic diseases [RCV002785079] Chr12:67649923 [GRCh38]
Chr12:68043703 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.742G>A (p.Val248Met) single nucleotide variant Inborn genetic diseases [RCV002949853] Chr12:67657649 [GRCh38]
Chr12:68051429 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.820C>T (p.Arg274Trp) single nucleotide variant Inborn genetic diseases [RCV002787674] Chr12:67657727 [GRCh38]
Chr12:68051507 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1250C>T (p.Thr417Met) single nucleotide variant Inborn genetic diseases [RCV002936755] Chr12:67658157 [GRCh38]
Chr12:68051937 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1496C>T (p.Ala499Val) single nucleotide variant Inborn genetic diseases [RCV002989120] Chr12:67658403 [GRCh38]
Chr12:68052183 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1494C>A (p.Asn498Lys) single nucleotide variant Inborn genetic diseases [RCV002680609] Chr12:67658401 [GRCh38]
Chr12:68052181 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1427T>C (p.Val476Ala) single nucleotide variant Inborn genetic diseases [RCV003217427] Chr12:67658334 [GRCh38]
Chr12:68052114 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.193C>T (p.His65Tyr) single nucleotide variant Inborn genetic diseases [RCV003184715] Chr12:67649940 [GRCh38]
Chr12:68043720 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1193G>C (p.Arg398Thr) single nucleotide variant Inborn genetic diseases [RCV003220450] Chr12:67658100 [GRCh38]
Chr12:68051880 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.1702C>T (p.Pro568Ser) single nucleotide variant Inborn genetic diseases [RCV003363603] Chr12:67658609 [GRCh38]
Chr12:68052389 [GRCh37]
Chr12:12q15
uncertain significance
NM_006482.3(DYRK2):c.374G>A (p.Arg125Gln) single nucleotide variant Inborn genetic diseases [RCV003378273] Chr12:67657281 [GRCh38]
Chr12:68051061 [GRCh37]
Chr12:12q15
uncertain significance
GRCh37/hg19 12q14.1-15(chr12:61755618-70035424)x1 copy number loss not provided [RCV003483154] Chr12:61755618..70035424 [GRCh37]
Chr12:12q14.1-15
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3546
Count of miRNA genes:1256
Interacting mature miRNAs:1631
Transcripts:ENST00000319833, ENST00000344096, ENST00000393555, ENST00000537632, ENST00000542503, ENST00000543747
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D12S1170E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,053,268 - 68,053,476UniSTSGRCh37
Build 361266,339,535 - 66,339,743RGDNCBI36
Celera1267,717,270 - 67,717,478RGD
Cytogenetic Map12q15UniSTS
HuRef1265,104,171 - 65,104,379UniSTS
STS-C14973  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,054,916 - 68,055,109UniSTSGRCh37
Build 361266,341,183 - 66,341,376RGDNCBI36
Celera1267,718,918 - 67,719,111RGD
Cytogenetic Map12q15UniSTS
HuRef1265,105,819 - 65,106,012UniSTS
GeneMap99-GB4 RH Map12279.5UniSTS
NCBI RH Map12532.2UniSTS
G20468  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,056,159 - 68,056,354UniSTSGRCh37
Build 361266,342,426 - 66,342,621RGDNCBI36
Celera1267,720,161 - 67,720,356RGD
Cytogenetic Map12q15UniSTS
HuRef1265,107,062 - 65,107,257UniSTS
A005S37  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,056,159 - 68,056,354UniSTSGRCh37
Build 361266,342,426 - 66,342,621RGDNCBI36
Celera1267,720,161 - 67,720,356RGD
Cytogenetic Map12q15UniSTS
HuRef1265,107,062 - 65,107,257UniSTS
GeneMap99-GB4 RH Map12277.77UniSTS
NCBI RH Map12534.4UniSTS
RH44483  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,056,166 - 68,056,321UniSTSGRCh37
Build 361266,342,433 - 66,342,588RGDNCBI36
Celera1267,720,168 - 67,720,323RGD
Cytogenetic Map12q15UniSTS
HuRef1265,107,069 - 65,107,224UniSTS
GeneMap99-GB4 RH Map12277.77UniSTS
NCBI RH Map12534.4UniSTS
STS-Y09216  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,052,494 - 68,052,588UniSTSGRCh37
Build 361266,338,761 - 66,338,855RGDNCBI36
Celera1267,716,496 - 67,716,590RGD
Cytogenetic Map12q15UniSTS
HuRef1265,103,397 - 65,103,491UniSTS
GeneMap99-GB4 RH Map12279.18UniSTS
NCBI RH Map12512.2UniSTS
D12S1545  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,050,712 - 68,050,824UniSTSGRCh37
Build 361266,336,979 - 66,337,091RGDNCBI36
Celera1267,714,714 - 67,714,826RGD
Cytogenetic Map12q15UniSTS
HuRef1265,101,615 - 65,101,727UniSTS
DYRK2__4797  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371268,051,983 - 68,052,834UniSTSGRCh37
Build 361266,338,250 - 66,339,101RGDNCBI36
Celera1267,715,985 - 67,716,836RGD
HuRef1265,102,886 - 65,103,737UniSTS
STS-R26535  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q15UniSTS
HuRef1265,105,292 - 65,105,461UniSTS
GeneMap99-GB4 RH Map12279.5UniSTS
NCBI RH Map12519.0UniSTS
WI-14800  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q15UniSTS
GeneMap99-GB4 RH Map12288.69UniSTS
Whitehead-RH Map12387.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1170 995 186 50 827 53 1383 562 214 170 501 656 9 356 825 3
Low 1268 1946 1537 570 1076 410 2973 1632 3468 249 953 957 165 1 848 1963 3
Below cutoff 49 3 2 47 2 2 48 5 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC078777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN303286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA768075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB461362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000319833   ⟹   ENSP00000324733
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1267,649,682 - 67,657,407 (+)Ensembl
RefSeq Acc Id: ENST00000344096   ⟹   ENSP00000342105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1267,648,745 - 67,665,406 (+)Ensembl
RefSeq Acc Id: ENST00000393555   ⟹   ENSP00000377186
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1267,648,778 - 67,658,909 (+)Ensembl
RefSeq Acc Id: ENST00000537632
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1267,649,121 - 67,652,700 (+)Ensembl
RefSeq Acc Id: ENST00000542503   ⟹   ENSP00000443314
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1267,651,469 - 67,657,475 (+)Ensembl
RefSeq Acc Id: ENST00000543747   ⟹   ENSP00000440839
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1267,648,338 - 67,657,596 (+)Ensembl
RefSeq Acc Id: NM_003583   ⟹   NP_003574
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381267,648,745 - 67,665,406 (+)NCBI
GRCh371268,042,512 - 68,056,444 (+)ENTREZGENE
Build 361266,328,779 - 66,342,711 (+)NCBI Archive
HuRef1265,093,416 - 65,107,347 (+)ENTREZGENE
CHM1_11268,010,112 - 68,024,043 (+)NCBI
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006482   ⟹   NP_006473
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381267,648,745 - 67,665,406 (+)NCBI
GRCh371268,042,512 - 68,056,444 (+)ENTREZGENE
Build 361266,328,779 - 66,342,711 (+)NCBI Archive
HuRef1265,093,416 - 65,107,347 (+)ENTREZGENE
CHM1_11268,010,112 - 68,024,043 (+)NCBI
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017020032   ⟹   XP_016875521
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381267,649,877 - 67,665,406 (+)NCBI
Sequence:
RefSeq Acc Id: NP_006473   ⟸   NM_006482
- Peptide Label: isoform 2
- UniProtKB: B2R9V9 (UniProtKB/Swiss-Prot),   Q9BRB5 (UniProtKB/Swiss-Prot),   Q92630 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003574   ⟸   NM_003583
- Peptide Label: isoform 1
- UniProtKB: Q92630 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016875521   ⟸   XM_017020032
- Peptide Label: isoform X1
- UniProtKB: Q92630 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000443314   ⟸   ENST00000542503
RefSeq Acc Id: ENSP00000440839   ⟸   ENST00000543747
RefSeq Acc Id: ENSP00000377186   ⟸   ENST00000393555
RefSeq Acc Id: ENSP00000324733   ⟸   ENST00000319833
RefSeq Acc Id: ENSP00000342105   ⟸   ENST00000344096
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q92630-F1-model_v2 AlphaFold Q92630 1-601 view protein structure

Promoters
RGD ID:6789877
Promoter ID:HG_KWN:16102
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_003583,   NM_006482
Position:
Human AssemblyChrPosition (strand)Source
Build 361266,328,086 - 66,328,937 (+)MPROMDB
RGD ID:6814519
Promoter ID:HG_XEF:1959
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_001108100
Position:
Human AssemblyChrPosition (strand)Source
Build 361266,329,406 - 66,330,312 (+)MPROMDB
RGD ID:6810269
Promoter ID:HG_ACW:17689
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:DYRK2.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361266,330,846 - 66,331,346 (+)MPROMDB
RGD ID:6789880
Promoter ID:HG_KWN:16103
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC009ZQU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361266,336,111 - 66,336,611 (+)MPROMDB
RGD ID:7224737
Promoter ID:EPDNEW_H18114
Type:initiation region
Name:DYRK2_1
Description:dual specificity tyrosine phosphorylation regulated kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381267,648,760 - 67,648,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3093 AgrOrtholog
COSMIC DYRK2 COSMIC
Ensembl Genes ENSG00000127334 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000319833.6 UniProtKB/TrEMBL
  ENST00000344096 ENTREZGENE
  ENST00000344096.4 UniProtKB/Swiss-Prot
  ENST00000393555 ENTREZGENE
  ENST00000393555.3 UniProtKB/Swiss-Prot
  ENST00000542503.1 UniProtKB/TrEMBL
  ENST00000543747.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000127334 GTEx
HGNC ID HGNC:3093 ENTREZGENE
Human Proteome Map DYRK2 Human Proteome Map
InterPro DYRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report hsa:8445 UniProtKB/Swiss-Prot
NCBI Gene 8445 ENTREZGENE
OMIM 603496 OMIM
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/Swiss-Prot
  DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB PA27550 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0A0MR56_HUMAN UniProtKB/TrEMBL
  B2R9V9 ENTREZGENE
  DYRK2_HUMAN UniProtKB/Swiss-Prot
  F5GXG1_HUMAN UniProtKB/TrEMBL
  F5H5L5_HUMAN UniProtKB/TrEMBL
  L8ECA4_HUMAN UniProtKB/TrEMBL
  Q92630 ENTREZGENE
  Q9BRB5 ENTREZGENE
UniProt Secondary B2R9V9 UniProtKB/Swiss-Prot
  Q9BRB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-16 DYRK2  dual specificity tyrosine phosphorylation regulated kinase 2    dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2  Symbol and/or name change 5135510 APPROVED
2015-11-24 DYRK2  dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2  Symbol and/or name change 5135510 APPROVED