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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydroxybenzaldehyde
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Accession:CHEBI:50196 term browser browse the term
Definition:Any member of the class of benzaldehydes in which the phenyl ring is substituted by two hydroxy groups.
Synonyms:related_synonym: Formula=C7H6O3


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2,5-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
3,4-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of ACHE protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein] CTD PMID:29665407, PMID:29732668 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:25582705 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO
EXP
protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]
CTD PMID:17597607, PMID:25582705 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Cat catalase multiple interactions
increases activity
ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
protocatechualdehyde results in increased activity of CAT protein
CTD PMID:29665407, PMID:29732668 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:25582705 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein]
CTD PMID:25582705 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of G6PD protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein] CTD PMID:29665407, PMID:29732668 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [sodium arsenite results in increased activity of GLO1 protein] CTD PMID:29732668 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:29665407, PMID:29732668 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]
CTD PMID:25582705 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:17597607 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in increased activity of SOD1 protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein] CTD PMID:29665407, PMID:29732668 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:17597607, PMID:25582705 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Vim vimentin multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:25582705 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        solvent 16456
          formic acid 7879
            formyl group 7845
              aldehyde 7845
                arenecarbaldehyde 124
                  benzaldehydes 122
                    dihydroxybenzaldehyde 17
                      2,3-dihydroxybenzaldehyde 0
                      2,4-dihydroxy-3,5,6-trimethylbenzaldehyde 0
                      2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 0
                      2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde 0
                      2,4-dihydroxy-5,6-dimethylbenzaldehyde 0
                      2,4-dihydroxy-6-methylbenzaldehyde 0
                      2,4-dihydroxybenzaldehyde 0
                      2,5-dihydroxybenzaldehyde 1
                      2,6-dihydroxybenzaldehyde 0
                      3,4-dihydroxybenzaldehyde 16
                      3,5-dihydroxybenzaldehyde 0
                      6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde 0
                      6-ethyl-2,4-dihydroxy-3,5-dimethylbenzaldehyde 0
                      FK17-P2a 0
                      ascochlorin 0
                      ascofuranol 0
                      ascofuranone 0
                      guangsangon L 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            formyl group 7845
                                              aldehyde 7845
                                                arenecarbaldehyde 124
                                                  benzaldehydes 122
                                                    dihydroxybenzaldehyde 17
                                                      2,3-dihydroxybenzaldehyde 0
                                                      2,4-dihydroxy-3,5,6-trimethylbenzaldehyde 0
                                                      2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 0
                                                      2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde 0
                                                      2,4-dihydroxy-5,6-dimethylbenzaldehyde 0
                                                      2,4-dihydroxy-6-methylbenzaldehyde 0
                                                      2,4-dihydroxybenzaldehyde 0
                                                      2,5-dihydroxybenzaldehyde 1
                                                      2,6-dihydroxybenzaldehyde 0
                                                      3,4-dihydroxybenzaldehyde 16
                                                      3,5-dihydroxybenzaldehyde 0
                                                      6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde 0
                                                      6-ethyl-2,4-dihydroxy-3,5-dimethylbenzaldehyde 0
                                                      FK17-P2a 0
                                                      ascochlorin 0
                                                      ascofuranol 0
                                                      ascofuranone 0
                                                      guangsangon L 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.