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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arenecarbaldehyde
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Accession:CHEBI:33855 term browser browse the term
Definition:Any aldehyde in which the carbonyl group is attached to an aromatic moiety.
Synonyms:related_synonym: Aromatic aldehyde;   Formula=CHOR;   SMILES=*C(=O)[H];   an aromatic aldehyde;   arenecarbaldehydes;   aryl aldehyde;   aryl aldehydes
 alt_id: CHEBI:13819;   CHEBI:22621;   CHEBI:2832;   CHEBI:87908
 xref: KEGG:C00193;   MetaCyc:Aryl-Aldehyde


show annotations for term's descendants           Sort by:
1-naphthaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions EXP 1-naphthaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
2,5-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
2-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a2 aldo-keto reductase family 7, member A2 increases reduction
affects reduction 		ISO AKR7A2 protein results in increased reduction of 2-nitrobenzaldehyde
2-nitrobenzaldehyde affects the reduction of AKR7A5 protein 		CTD PMID:10510318 PMID:12604212 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
3,4-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of ACHE protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein] CTD PMID:29665407 PMID:29732668 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:25582705 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO
EXP 		protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein] 		CTD PMID:17597607 PMID:25582705 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Cat catalase multiple interactions
increases activity 		ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
protocatechualdehyde results in increased activity of CAT protein 		CTD PMID:29665407 PMID:29732668 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:25582705 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP 		protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein] 		CTD PMID:25582705 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of G6PD protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein] CTD PMID:29665407 PMID:29732668 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [sodium arsenite results in increased activity of GLO1 protein] CTD PMID:29732668 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:29665407 PMID:29732668 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO 		protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein] 		CTD PMID:25582705 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:17597607 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in increased activity of SOD1 protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein] CTD PMID:29665407 PMID:29732668 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:17597607 PMID:25582705 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Vim vimentin multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:25582705 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
3,5-di-tert-Butyl-4-hydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of THRB protein CTD PMID:27633901 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
3-hydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing ISO ALDH2 protein results in increased metabolism of 3-hydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
3-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 3-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of 3-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 affects reduction ISO 3-nitrobenzaldehyde affects the reduction of AKR7A5 protein; 3-nitrobenzaldehyde analog affects the reduction of AKR7A5 protein CTD PMID:12604212 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
4-(diethylamino)benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases activity
multiple interactions
increases oxidation 		ISO 4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein
4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide]
ALDH1A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde 		CTD PMID:8662658 PMID:16316642 PMID:25512087 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions ISO 4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH1A2 protein CTD PMID:25512087 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO 4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH2 protein CTD PMID:25512087 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases oxidation ISO ALDH3A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde CTD PMID:25512087 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
4-chlorobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c13 aldo-keto reductase family 1, member C13 increases reduction
multiple interactions 		EXP AKR1C13 protein results in increased reduction of 4-chlorobenzaldehyde
AKR1C13 protein results in increased metabolism of [4-chlorobenzaldehyde co-treated with NAD] 		CTD PMID:16788056 NCBI chr17:65,964,186...65,997,598
Ensembl chr17:65,964,975...65,997,591 		JBrowse link
4-formylbenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 4-carboxybenzaladehyde CTD PMID:10510318 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
4-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases metabolic processing
multiple interactions 		ISO
EXP 		AKR1B15 protein results in increased metabolism of 4-nitrobenzaldehyde
[AKR1B8 protein co-treated with NADP] affects the reduction of 4-nitrobenzaldehyde 		CTD PMID:18845131 PMID:21276782 NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions
affects reduction 		ISO Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Indomethacin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Quercetin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Valproic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein] CTD PMID:12604212 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 multiple interactions ISO [Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein CTD PMID:33617879 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 4-nitrobenzaldehyde] CTD PMID:20932822 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
5-hydroxymethylfurfural term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin decreases expression EXP 5-hydroxymethylfurfural co-treated with 3,4-dideoxyglucosone co-treated with Glyoxal co-treated with Methylglyoxal cotreated with 3-deoxyglucosone co-treated with Formaldehyde co-treated with acetaldehyde decreases expression of Nphs1 protein in kidneys RGD PMID:18346151 RGD:38599007 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects metabolic processing
increases metabolic processing
increases activity
multiple interactions
affects activity 		ISO
EXP 		SULT1A1 protein affects the metabolism of 5-hydroxymethylfurfural
SULT1A1 protein results in increased metabolism of 5-hydroxymethylfurfural
SULT1A1 protein results in increased activity of 5-hydroxymethylfurfural
[SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural
5-hydroxymethylfurfural affects the activity of SULT1A1 protein 		CTD PMID:22006426 PMID:22349055 PMID:22563731 PMID:25370010 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
ascofuranone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO ascofuranone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of BRAF protein] CTD PMID:17114644 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ascofuranone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein] CTD PMID:17114644 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ascofuranone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased phosphorylation of MAPK1 protein] CTD PMID:17114644 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ascofuranone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased phosphorylation of MAPK3 protein] CTD PMID:17114644 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP 		ascofuranone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 mRNA]; ascofuranone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; ascofuranone inhibits the reaction [TNF protein results in increased secretion of MMP9 protein] CTD PMID:17114644 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ascofuranone inhibits the reaction [TNF protein results in increased secretion of MMP9 protein] CTD PMID:17114644 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of benzaldehyde CTD PMID:18845131 NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases oxidation
increases metabolic processing 		EXP
ISO 		ALDH1A1 protein results in increased oxidation of benzaldehyde
ALDH1A1 protein results in increased metabolism of benzaldehyde 		CTD PMID:10998257 PMID:21256123 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases oxidation EXP ALDH1A7 protein results in increased oxidation of benzaldehyde CTD PMID:10998257 NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:218,201,472...218,248,906 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing
multiple interactions 		ISO ALDH2 protein results in increased metabolism of benzaldehyde
benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein] 		CTD PMID:10609638 PMID:11744614 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions
increases oxidation
increases metabolic processing 		ISO [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
ALDH3A1 protein results in increased metabolism of benzaldehyde 		CTD PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding ISO benzaldehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921 		JBrowse link
G Ar androgen receptor multiple interactions EXP benzaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Or8a1b olfactory receptor family 8 subfamily A member 1B multiple interactions ISO benzaldehyde binds to and results in increased activity of OR8A1 protein CTD PMID:11943806 NCBI chr 8:37,434,903...37,435,832
Ensembl chr 8:37,434,551...37,439,746 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases activity
multiple interactions 		ISO benzaldehyde results in increased activity of SLC2A1 protein
[benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein 		CTD PMID:20955755 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
benzaldehydes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases activity ISO Benzaldehydes results in decreased activity of ALDH1A2 protein CTD PMID:22079344 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity ISO Benzaldehydes results in decreased activity of ALDH2 protein CTD PMID:22079344 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO [ethyl vanillin binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OR5D18 protein CTD PMID:15716417 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
m-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP 3-methylbenzaldehyde results in decreased activity of CYP2B1 protein CTD PMID:12791539 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP 3-methylbenzaldehyde results in decreased activity of CYP2E1 protein CTD PMID:12791539 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects activity EXP 3-methylbenzaldehyde affects the activity of CYP4B1 protein CTD PMID:12791539 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
oncrasin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein mutant form results in increased susceptibility to oncrasin-1 CTD PMID:21443218 NCBI chr 4:179,916,255...179,949,613 JBrowse link
ortho-vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
p-methoxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 4-anisaldehyde results in increased activity of TRPA1 protein CTD PMID:21591660 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
p-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of AHR protein CTD PMID:27633901 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of ESR2 protein CTD PMID:27633901 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IL1B protein] CTD PMID:27569861 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:27569861 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27569861 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27569861 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:27569861 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:27569861 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27569861 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:27569861 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:27569861 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:27569861 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
phthalaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression ISO o-Phthalaldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects expression ISO o-Phthalaldehyde affects the expression of AKR1C18 mRNA CTD PMID:22302311 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 affects expression ISO o-Phthalaldehyde affects the expression of CCL6 mRNA CTD PMID:22302311 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO o-Phthalaldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO o-Phthalaldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne2 cyclin E2 affects expression ISO o-Phthalaldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression ISO o-Phthalaldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Cd207 CD207 molecule affects expression ISO o-Phthalaldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518 		JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO o-Phthalaldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cd83 CD83 molecule affects expression ISO o-Phthalaldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cdc20 cell division cycle 20 affects expression ISO o-Phthalaldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdc25c cell division cycle 25C affects expression ISO o-Phthalaldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO o-Phthalaldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Clec7a C-type lectin domain containing 7A affects expression ISO o-Phthalaldehyde affects the expression of CLEC7A mRNA CTD PMID:22302311 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Col8a1 collagen type VIII alpha 1 chain affects expression ISO o-Phthalaldehyde affects the expression of COL8A1 mRNA CTD PMID:22302311 NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424 		JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression ISO o-Phthalaldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr16:1,533,883...1,537,248
Ensembl chr16:1,528,440...1,537,082 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression ISO o-Phthalaldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA CTD PMID:20112102 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA CTD PMID:20112102 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO o-Phthalaldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO o-Phthalaldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression ISO o-Phthalaldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637 		JBrowse link
G Gzmb granzyme B affects expression ISO o-Phthalaldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Ifng interferon gamma increases expression ISO o-Phthalaldehyde results in increased expression of IFNG mRNA CTD PMID:21785612 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression ISO o-Phthalaldehyde results in increased expression of IL10 mRNA CTD PMID:21785612 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B affects expression ISO o-Phthalaldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 increases expression ISO o-Phthalaldehyde results in increased expression of IL13 mRNA CTD PMID:21785612 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO o-Phthalaldehyde results in increased expression of IL1B mRNA CTD PMID:21785612 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il21 interleukin 21 affects expression ISO o-Phthalaldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha affects expression ISO o-Phthalaldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il4 interleukin 4 affects expression
increases expression 		ISO o-Phthalaldehyde affects the expression of IL4 mRNA
o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein 		CTD PMID:19110043 PMID:20176622 PMID:21785612 PMID:22302311 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases expression ISO o-Phthalaldehyde results in increased expression of IL5 mRNA CTD PMID:19110043 PMID:21785612 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Itgav integrin subunit alpha V affects expression ISO o-Phthalaldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO o-Phthalaldehyde inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Lgals7 galectin 7 affects expression ISO o-Phthalaldehyde affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015 		JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO o-Phthalaldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nts neurotensin affects expression ISO o-Phthalaldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO o-Phthalaldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO o-Phthalaldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:23,983,158...24,026,313 		JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO o-Phthalaldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO o-Phthalaldehyde affects the expression of TIMP1 mRNA CTD PMID:22302311 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO o-Phthalaldehyde results in increased expression of TNF mRNA CTD PMID:21785612 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO o-Phthalaldehyde affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression ISO o-Phthalaldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520 		JBrowse link
vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein] CTD PMID:33823243 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO vanillin results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO vanillin results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO vanillin results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; vanillin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein] CTD PMID:29216766 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO
EXP 		vanillin inhibits the reaction [potassium bromate results in increased activity of CAT protein]
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein] 		CTD PMID:26296324 PMID:33823243 PMID:37336463 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] CTD PMID:36416909 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO vanillin results in decreased expression of CCN2 mRNA CTD PMID:17178418 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Clk2 CDC-like kinase 2 increases expression ISO vanillin results in increased expression of CLK2 mRNA CTD PMID:17178418 NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985 		JBrowse link
G Cst3 cystatin C multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased expression of CST3 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of CST3 protein] CTD PMID:29216766 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO vanillin results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO vanillin results in increased expression of DDIT4 mRNA CTD PMID:17178418 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO vanillin results in decreased expression of DNMT3B mRNA CTD PMID:17178418 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO vanillin results in decreased expression of DUSP6 mRNA CTD PMID:17178418 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Faslg Fas ligand multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased expression of FASLG protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of FASLG protein] CTD PMID:29216766 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 affects binding ISO vanillin binds to FBP1 protein CTD PMID:33823243 NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO vanillin results in decreased expression of FGFR2 mRNA CTD PMID:17178418 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO vanillin results in decreased expression of FZD2 mRNA CTD PMID:17178418 NCBI chr10:88,061,988...88,063,898
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects binding ISO vanillin binds to G6PC1 protein CTD PMID:33823243 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:37336463 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GAPDH protein] CTD PMID:37336463 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO vanillin results in increased expression of GCLM mRNA CTD PMID:17178418 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GLO1 protein] CTD PMID:37336463 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:37336463 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO vanillin results in increased expression of HMOX1 mRNA CTD PMID:17178418 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases mutagenesis ISO vanillin results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO vanillin results in increased expression of HSPA1B mRNA CTD PMID:17178418 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO vanillin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased expression of IL18 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of IL18 protein] CTD PMID:29216766 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of IL1B mRNA] CTD PMID:26296324 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of IL6 mRNA] CTD PMID:26296324 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO vanillin results in decreased expression of INSIG1 mRNA CTD PMID:17178418 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO vanillin results in decreased expression of JUND mRNA CTD PMID:17178418 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased expression of LCN2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of LCN2 protein] CTD PMID:29216766 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects lipidation ISO vanillin affects the lipidation of MAP1LC3B protein CTD PMID:38608998 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO vanillin results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mark4 microtubule affinity regulating kinase 4 decreases expression ISO vanillin results in decreased expression of MARK4 mRNA CTD PMID:17178418 NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO vanillin inhibits the reaction [potassium bromate results in increased expression of MT1 mRNA] CTD PMID:27074584 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mt2 metallothionein 2 increases expression
multiple interactions 		ISO vanillin results in increased expression of MT2A mRNA
vanillin inhibits the reaction [potassium bromate results in increased expression of MT2 mRNA] 		CTD PMID:20491607 PMID:27074584 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] CTD PMID:29216766 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO vanillin results in decreased expression of PPP1R10 mRNA CTD PMID:17178418 NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase affects expression ISO vanillin affects the expression of PRKN protein CTD PMID:38608998 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO vanillin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; vanillin inhibits the reaction [potassium bromate results in increased expression of PTGS2 mRNA] CTD PMID:17465205 PMID:26296324 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pygl glycogen phosphorylase L affects binding ISO vanillin binds to PYGL protein CTD PMID:33823243 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP vanillin inhibits the reaction [Cisplatin results in increased expression of RELA protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of RELA protein] CTD PMID:29216766 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc35d2 solute carrier family 35 member D2 decreases expression ISO vanillin results in decreased expression of SLC35D2 mRNA CTD PMID:17178418 NCBI chr17:987,899...1,019,747
Ensembl chr17:988,157...1,019,743 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO vanillin results in increased expression of SLC7A11 mRNA CTD PMID:17178418 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 decreases expression ISO vanillin results in decreased expression of TGFB1I1 mRNA CTD PMID:17178418 NCBI chr 1:192,258,992...192,265,903
Ensembl chr 1:182,828,544...182,837,080 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		vanillin inhibits the reaction [potassium bromate results in increased expression of TNF mRNA]
vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
vanillin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of TNF protein] 		CTD PMID:26296324 PMID:29216766 PMID:36416909 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO vanillin results in decreased expression of TP53 mRNA CTD PMID:17178418 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO vanillin results in increased expression of TRIM16 mRNA CTD PMID:17178418 NCBI chr10:47,485,982...47,509,010
Ensembl chr10:47,486,297...47,551,907 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO vanillin results in increased expression of UGP2 mRNA CTD PMID:17178418 NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        solvent 17470
          formic acid 9446
            formyl group 9407
              aldehyde 9407
                arenecarbaldehyde 146
                  1,3-Dimethyl-1H-pyrazole-4-carbaldehyde 0
                  1,3-thiazole-2-carbaldehyde + 0
                  1-Ethyl-1H-pyrrole-2-carboxaldehyde 0
                  1-Methyl-2-pyrrolecarboxaldehyde 0
                  1-acetylindole-3-carboxaldehyde 0
                  2,5-diformylfuran 0
                  2,5-dimethyl-1-(phenylmethyl)pyrrole-3,4-dicarboxaldehyde 0
                  2-(dihydroxymethyl)-5-formylfuran 0
                  4'-methyl-2,2'-bipyridine-4-carboxaldehyde 0
                  4-(phosphooxymethyl)-2-furancarboxaldehyde 0
                  4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde 0
                  4-ethylpyrrole-2-carboxaldehyde 0
                  5-(\{5-[(5-(hydroxymethyl)furan-2-yl)methoxy(methoxymethyl)]furan-2-yl\}methoxy(methoxymethyl))furan-2-carbaldehyde 0
                  5-Methoxymethyl furfural 0
                  5-Sulfoxymethylfurfural 0
                  5-[(5-hydroxymethyl-furan-2-yl)methoxy-methoxymethyl]-furan-2-carbaldehyde 0
                  5-formyl-2-furoic acid 0
                  5-hydroxymethylfurfural 2
                  8-formyl-8-demethylriboflavin 5'-phosphate 0
                  Baldrinal 0
                  Ganoine 0
                  Irpexlacte B 0
                  Irpexlacte C 0
                  Jiangrine E 0
                  N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide 0
                  N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide 0
                  Phlebopine A 0
                  Phlebopine B 0
                  Viburtinal 0
                  aromatic (S)-hydroxynitrile 0
                  benzaldehydes + 143
                  cyathusal A 0
                  cyathusal B 0
                  cyathusal C 0
                  demethylzeylasteral 0
                  grixazone A 0
                  kadsurenin M 0
                  mycobilin a 0
                  mycobilin b 0
                  naphthaldehydes + 1
                  oncrasin-1 1
                  piperonal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          formyl group 9407
                                            aldehyde 9407
                                              arenecarbaldehyde 146
                                                1,3-Dimethyl-1H-pyrazole-4-carbaldehyde 0
                                                1,3-thiazole-2-carbaldehyde + 0
                                                1-Ethyl-1H-pyrrole-2-carboxaldehyde 0
                                                1-Methyl-2-pyrrolecarboxaldehyde 0
                                                1-acetylindole-3-carboxaldehyde 0
                                                2,5-diformylfuran 0
                                                2,5-dimethyl-1-(phenylmethyl)pyrrole-3,4-dicarboxaldehyde 0
                                                2-(dihydroxymethyl)-5-formylfuran 0
                                                4'-methyl-2,2'-bipyridine-4-carboxaldehyde 0
                                                4-(phosphooxymethyl)-2-furancarboxaldehyde 0
                                                4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde 0
                                                4-ethylpyrrole-2-carboxaldehyde 0
                                                5-(\{5-[(5-(hydroxymethyl)furan-2-yl)methoxy(methoxymethyl)]furan-2-yl\}methoxy(methoxymethyl))furan-2-carbaldehyde 0
                                                5-Methoxymethyl furfural 0
                                                5-Sulfoxymethylfurfural 0
                                                5-[(5-hydroxymethyl-furan-2-yl)methoxy-methoxymethyl]-furan-2-carbaldehyde 0
                                                5-formyl-2-furoic acid 0
                                                5-hydroxymethylfurfural 2
                                                8-formyl-8-demethylriboflavin 5'-phosphate 0
                                                Baldrinal 0
                                                Ganoine 0
                                                Irpexlacte B 0
                                                Irpexlacte C 0
                                                Jiangrine E 0
                                                N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide 0
                                                N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide 0
                                                Phlebopine A 0
                                                Phlebopine B 0
                                                Viburtinal 0
                                                aromatic (S)-hydroxynitrile 0
                                                benzaldehydes + 143
                                                cyathusal A 0
                                                cyathusal B 0
                                                cyathusal C 0
                                                demethylzeylasteral 0
                                                grixazone A 0
                                                kadsurenin M 0
                                                mycobilin a 0
                                                mycobilin b 0
                                                naphthaldehydes + 1
                                                oncrasin-1 1
                                                piperonal 0
paths to the root