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N-sulfonylurea - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-sulfonylurea
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Accession:CHEBI:76983 term browser browse the term
Definition:A urea in which one of the hydrogens attached to a nitrogen of the urea group is replaced by a sulfonyl group. The N-sulfonylurea moiety is a key group in various herbicides, as well as in a number of antidiabetic drugs used in the management of type 2 diabetis mellitus.
Synonyms:related_synonym: Formula=CN2O3SR4;   N-sulfonylureas;   SMILES=[*]S(=O)(=O)N([*])C(=O)N([*])[*];   sulfonylurea;   sulfonylureas
 xref: PMID:23237384;   PMID:23594109;   PMID:23609875;   Wikipedia:Sulfonylurea


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acetohexamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP Acetohexamide binds to ALB protein; Acetohexamide binds to ALB protein modified form CTD PMID:20435530 PMID:20829128 PMID:20956006 PMID:20974553 PMID:21612784 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G DHRS3 dehydrogenase/reductase 3 increases metabolic processing EXP DHRS3 protein results in increased metabolism of Acetohexamide CTD PMID:25451588 NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,909...12,620,133
JBrowse link
bensulfuron-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP methyl bensulfuron results in increased activity of NR1I2 protein CTD PMID:22206814 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
chlorpropamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Chlorpropamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G AVP arginine vasopressin decreases secretion EXP Chlorpropamide results in decreased secretion of AVP protein modified form CTD PMID:5029389 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Chlorpropamide results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190
JBrowse link
G INS insulin decreases expression
increases expression
multiple interactions
EXP Chlorpropamide results in decreased expression of INS protein
Chlorpropamide results in increased expression of INS mRNA
Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]
CTD PMID:15642492 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331
JBrowse link
gliclazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP Gliclazide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G ALB albumin affects binding
multiple interactions
EXP
ISO
Gliclazide binds to ALB protein
Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein]
CTD PMID:14871415 PMID:20974553 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP Gliclazide inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:18088078 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
EXP
ISO
Gliclazide inhibits the reaction [Glucose results in increased expression of CASP3 protein]
Gliclazide results in decreased expression of CASP3 mRNA
Gliclazide inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]
CTD PMID:18088078 PMID:32045587 PMID:33652124 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions ISO Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A mRNA] CTD PMID:12646174 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Gliclazide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28330423 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GLO1 glyoxalase I multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein] CTD PMID:21439372 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein] CTD PMID:20307516 PMID:21439372 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTM3 glutathione S-transferase mu 3 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA] CTD PMID:21439372 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]
Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein]
CTD PMID:12646174 PMID:21439372 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of ICAM1 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of ICAM1 protein] CTD PMID:14871415 PMID:32045587 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL10 interleukin 10 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein] CTD PMID:32045587 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL1B protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 PMID:32045587 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Gliclazide inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:28330423 PMID:28625491 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:32045587 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:32045587 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:32045587 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased activity of MPO protein] CTD PMID:32045587 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of NCF1 protein] CTD PMID:14871415 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein] CTD PMID:21439372 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression ISO Gliclazide results in increased expression of NOS3 protein CTD PMID:14871415 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of PPARG protein] CTD PMID:32045587 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 protein] CTD PMID:14871415 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of TNF protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Gliclazide results in decreased expression of TNF protein
CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions ISO Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA] CTD PMID:12646174 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314
JBrowse link
G TP53 tumor protein p53 increases expression EXP Gliclazide results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
glimepiride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
EXP glimepiride results in decreased activity of ABCB11 protein
glimepiride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 decreases activity EXP glimepiride results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP glimepiride results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G CAPN1 calpain 1 increases expression EXP glimepiride results in increased expression of CAPN1 mRNA CTD PMID:33652124 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN10 calpain 10 increases expression EXP glimepiride results in increased expression of CAPN10 mRNA CTD PMID:33652124 NCBI chr 2:240,586,734...240,599,104
Ensembl chr 2:240,586,734...240,617,705
JBrowse link
G CAPN2 calpain 2 increases expression EXP glimepiride results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP3 caspase 3 increases expression
increases activity
EXP glimepiride results in increased expression of CASP3 mRNA
glimepiride results in increased activity of CASP3 protein
CTD PMID:33652124 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP [glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G HLA-G major histocompatibility complex, class I, G affects expression EXP glimepiride affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125
JBrowse link
G INS insulin decreases expression EXP glimepiride results in decreased expression of INS protein CTD PMID:15642492 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO [Plant Extracts co-treated with glimepiride] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; glimepiride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:26721197 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP glimepiride results in increased activity of NR1I2 protein
[glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP glimepiride affects the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 multiple interactions EXP glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
G TP53 tumor protein p53 increases expression EXP glimepiride results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
EXP Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 decreases activity EXP Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 decreases activity EXP Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases metabolic processing
decreases metabolic processing
EXP CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide
CTD PMID:10208645 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression
decreases activity
EXP
ISO
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Glyburide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of ABCB11 mRNA
Glyburide results in increased expression of ABCB11 mRNA
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium
CTD PMID:11343252 PMID:15465654 PMID:15618715 PMID:19853032 PMID:20147439 More... NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 increases expression ISO Glyburide results in increased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases activity EXP Glyburide results in decreased activity of ABCC1 protein CTD PMID:15652236 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO Glyburide results in increased expression of ABCC2 mRNA CTD PMID:27765674 PMID:35708773 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO Glyburide results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) increases expression ISO Glyburide results in increased expression of ABCC4 mRNA CTD PMID:35708773 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 increases response to substance
affects binding
multiple interactions
ISO ABCC8 protein results in increased susceptibility to Glyburide
Glyburide binds to ABCC8 protein; Glyburide binds to ABCC8 protein mutant form
Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]; resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]
CTD PMID:17138562 PMID:19095654 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 affects binding
decreases activity
multiple interactions
ISO Glyburide binds to ABCC9 protein mutant form
Glyburide results in decreased activity of ABCC9 protein
[Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein; Estradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]; resveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]
CTD PMID:17138562 PMID:19095654 PMID:22622455 PMID:28842488 NCBI chr12:21,797,389...21,941,426
Ensembl chr12:21,797,389...21,942,543
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) decreases export
multiple interactions
increases export
EXP ABCG2 protein polymorphism results in decreased export of Glyburide
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]; Genistein inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]
CTD PMID:26850786 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 increases expression ISO Glyburide results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Glyburide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]] CTD PMID:35305975 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP Glyburide inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:10799337 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]
CTD PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 decreases activity EXP Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 decreases activity EXP Glyburide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP Glyburide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein] CTD PMID:21800153 PMID:26286522 PMID:33724628 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G ALB albumin affects binding
multiple interactions
EXP
ISO
Glyburide binds to ALB protein
Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of ALB protein]
CTD PMID:20974553 PMID:36510688 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions EXP Glyburide promotes the reaction [1,2-linoleoylphosphatidylcholine results in increased secretion of APOA1 protein]; Glyburide promotes the reaction [Clofibrate results in increased secretion of APOA1 protein] CTD PMID:19717637 NCBI chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G ARG1 arginase 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]
CTD PMID:32522579 PMID:32860822 PMID:34052309 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of BAX protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:33724628 PMID:36510688 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of BCL2 protein]; Glyburide inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:21800153 PMID:33724628 PMID:36510688 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CAPN2 calpain 2 increases expression EXP Glyburide results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP1 caspase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Ozone results in increased cleavage of CASP1 protein]
CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Glyburide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of CASP3 protein]; Glyburide inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP3 protein]]; Glyburide inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]]
Glyburide results in increased expression of CASP3 mRNA
Glyburide results in increased activity of CASP3 protein
CTD PMID:16310184 PMID:33030052 PMID:33652124 PMID:35305975 PMID:36504472 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP9 caspase 9 multiple interactions ISO Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of CASP9 protein]; Glyburide inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP9 protein]] CTD PMID:33030052 PMID:36510688 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]]
CTD PMID:23716880 PMID:24760747 PMID:26286522 PMID:26700463 PMID:26748309 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions
decreases activity
EXP
ISO
Glyburide binds to and results in decreased activity of CFTR protein; Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]
Glyburide results in decreased activity of CFTR protein
Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]
Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]; Glyburide inhibits the reaction [CFTR protein affects the transport of Chlorides]
CTD PMID:14502435 PMID:14967738 PMID:15131065 PMID:15236628 PMID:15371258 More... NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression ISO Glyburide results in decreased expression of COL1A1 mRNA CTD PMID:35708773 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G CP ceruloplasmin multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein] CTD PMID:26748309 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CST3 cystatin C multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA; Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]; pyrvinium inhibits the reaction [[Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]] CTD PMID:35305975 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein] CTD PMID:32375810 PMID:34052309 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10799337 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]] CTD PMID:27890915 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]] CTD PMID:35305975 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions ISO Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:25641191 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PC3 glucose-6-phosphatase catalytic subunit 3 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] CTD PMID:31345080 NCBI chr17:44,070,673...44,076,344
Ensembl chr17:44,070,620...44,082,151
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 PMID:31345080 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSDMD gasdermin D multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of GSR protein] CTD PMID:26748309 PMID:33724628 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of HMOX1 mRNA]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:30817903 PMID:36510688 PMID:36999408 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G IFNG interferon gamma multiple interactions ISO Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL12B interleukin 12B multiple interactions ISO Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863
JBrowse link
G IL17A interleukin 17A multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]] CTD PMID:35305975 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]
Glyburide inhibits the reaction [Ozone results in increased expression of IL18 protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]
CTD PMID:25338942 PMID:32167222 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
JBrowse link
G IL1B interleukin 1 beta affects secretion
multiple interactions
ISO
EXP
Glyburide affects the secretion of IL1B protein
Glyburide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased secretion of IL1B protein]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Ozone results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
CTD PMID:15578659 PMID:25338942 PMID:30817903 PMID:32167222 PMID:32375810 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
CTD PMID:24760747 PMID:24849676 PMID:26748309 PMID:30817903 PMID:33724628 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions
increases response to substance
increases secretion
increases expression
decreases expression
EXP
ISO
[Glyburide co-treated with Glucose] results in increased expression of INS protein; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]
[Glyburide co-treated with Streptozocin] results in increased secretion of INS protein
Glyburide results in increased susceptibility to INS protein
Glyburide results in increased expression of INS mRNA
Glyburide results in decreased expression of INS protein
CTD PMID:3116364 PMID:10430617 PMID:11305519 PMID:15066220 PMID:15642492 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions
increases secretion
ISO Glyburide inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Glyburide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
Glyburide results in increased secretion of INS1 protein
Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]
CTD PMID:26286522 PMID:26700463 PMID:26748309 PMID:29658312 PMID:30445784 More... NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G INSR insulin receptor multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of INSR protein] CTD PMID:26286522 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions EXP
ISO
IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]
Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]
CTD PMID:10430617 PMID:26286522 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:26286522 PMID:33724628 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein] CTD PMID:32522579 PMID:32860822 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Glyburide results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions
decreases response to substance
ISO Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]
KCNJ11 protein mutant form results in decreased susceptibility to Glyburide
CTD PMID:15949470 PMID:28842488 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331
JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 decreases activity
decreases response to substance
EXP
ISO
Glyburide results in decreased activity of KCNJ8 protein
KCNJ8 protein mutant form results in decreased susceptibility to Glyburide
CTD PMID:20050851 PMID:28842488 NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600
JBrowse link
G KCNK18 potassium two pore domain channel subfamily K member 18 multiple interactions EXP Glyburide inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr10:117,197,489...117,210,299
Ensembl chr10:117,197,489...117,210,299
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of KEAP1 mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 PMID:36510688 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LYZ lysozyme increases secretion
decreases secretion
EXP Glyburide results in increased secretion of LYZ protein
Glyburide results in decreased secretion of LYZ protein
CTD PMID:15194485 PMID:15234967 NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases expression
ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK1 protein modified form] CTD PMID:20860660 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases expression
ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK3 protein modified form] CTD PMID:20860660 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MBP myelin basic protein multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
JBrowse link
G MIR146A microRNA 146a multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased activity of MPO protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of MPO protein] CTD PMID:25338942 PMID:35305975 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NCF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:32375810 PMID:34052309 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NEFL neurofilament light chain multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein] CTD PMID:32522579 PMID:32860822 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO Glyburide inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]] CTD PMID:27246103 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 mRNA]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 PMID:36510688 PMID:36999408 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Ozone results in increased expression of NLRP3 protein]
CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; KN 93 inhibits the reaction [Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of NOS2 mRNA]
CTD PMID:16257489 PMID:27246103 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]] CTD PMID:27890915 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 decreases expression ISO Glyburide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G PKLR pyruvate kinase L/R multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] CTD PMID:29223569 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of PTGS2 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:30817903 PMID:36510688 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:25338942 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of RELA protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:33724628 PMID:36504472 PMID:36510688 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression
multiple interactions
ISO Glyburide results in decreased expression of SLC10A1 mRNA
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of SLC10A1 mRNA
CTD PMID:27765674 PMID:28391356 PMID:35708773 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein] CTD PMID:33724628 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:26286522 PMID:29223569 PMID:33724628 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions ISO Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:16725203 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP Glyburide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 multiple interactions EXP Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
G SNCA synuclein alpha multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein] CTD PMID:32375810 PMID:34052309 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]] CTD PMID:35305975 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:16725203 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP Glyburide results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]]
CTD PMID:16257489 PMID:24760747 PMID:26748309 PMID:30817903 PMID:32375810 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]] CTD PMID:35305975 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 protein]
Glyburide results in increased expression of TP53 mRNA
CTD PMID:30817903 PMID:33387473 PMID:33652124 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 decreases activity ISO Glyburide results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr19:49,157,792...49,211,836
Ensembl chr19:49,157,741...49,211,836
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO [Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein CTD PMID:22622455 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
metsulfuron methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO metsulfuron methyl binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ODC1 ornithine decarboxylase 1 decreases expression ISO metsulfuron methyl results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
tolazamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS-IGF2 INS-IGF2 readthrough increases response to substance ISO Tolazamide results in increased susceptibility to INS1 protein CTD PMID:6337899 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
tolbutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity
multiple interactions
EXP Tolbutamide results in decreased activity of ABCB1 protein
Tolbutamide inhibits the reaction [ABCB1 protein results in increased uptake of quinidinium]
CTD PMID:32305507 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] CTD PMID:9568693 PMID:18025464 PMID:22209866 NCBI chr11:17,392,498...17,476,845
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G ALB albumin affects binding EXP Tolbutamide binds to ALB protein CTD PMID:19596536 PMID:20435530 PMID:20956006 PMID:20974553 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G CCND1 cyclin D1 increases expression ISO Tolbutamide results in increased expression of CCND1 protein CTD PMID:16718685 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND3 cyclin D3 increases expression ISO Tolbutamide results in increased expression of CCND3 protein CTD PMID:16718685 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein] CTD PMID:16718685 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression ISO Tolbutamide results in increased expression of CDKN1B protein CTD PMID:16718685 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 increases metabolic processing EXP CYP2C18 results in increased metabolism of Tolbutamide CTD PMID:15301741 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases metabolic processing
increases hydroxylation
multiple interactions
EXP CYP2C19 protein results in increased metabolism of Tolbutamide
CYP2C19 protein results in increased hydroxylation of Tolbutamide
[CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:18511451 PMID:30500380 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C23P cytochrome P450 family 2 subfamily C member 23, pseudogene multiple interactions
increases metabolic processing
ISO [CYP2C23 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr10:100,105,754...100,140,151
Ensembl chr10:100,105,754...100,140,151
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases hydroxylation EXP CYP2C8 protein results in increased hydroxylation of Tolbutamide CTD PMID:15843491 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases metabolic processing
increases hydroxylation
increases chemical synthesis
affects metabolic processing
affects hydroxylation
decreases hydroxylation
decreases metabolic processing
increases hydrolysis
EXP
ISO
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C65 protein results in increased metabolism of Tolbutamide
[CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 More... NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G GCG glucagon increases secretion ISO Tolbutamide results in increased secretion of GCG protein CTD PMID:15919803 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions
increases expression
ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein]; Tolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]
Tolbutamide results in increased expression of GJA1 protein
CTD PMID:11741589 PMID:16718685 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G HK1 hexokinase 1 increases expression ISO Tolbutamide results in increased expression of HK1 protein CTD PMID:11835228 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884
JBrowse link
G INS insulin multiple interactions
increases secretion
EXP ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9032110 PMID:9568693 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INS-IGF2 INS-IGF2 readthrough affects secretion
multiple interactions
ISO Tolbutamide affects the secretion of INS1 protein
[Tolbutamide co-treated with FR900359] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Tolbutamide inhibits the reaction [arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [methylarsonite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide promotes the reaction [Glucose results in increased secretion of INS1 protein]
CTD PMID:9366569 PMID:31332465 PMID:37217659 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions
decreases activity
EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]
Tolbutamide results in decreased activity of KCNJ11 protein
CTD PMID:18025464 PMID:22209866 NCBI chr11:17,385,248...17,389,346
Ensembl chr11:17,365,172...17,389,331
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression ISO Tolbutamide results in decreased expression of MKI67 protein CTD PMID:16718685 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G PDCD4 programmed cell death 4 decreases expression
increases expression
EXP Tolbutamide results in decreased expression of PDCD4 mRNA
Tolbutamide results in increased expression of PDCD4 mRNA
CTD PMID:21873647 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tolbutamide results in decreased phosphorylation of RB1 protein CTD PMID:16718685 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression ISO Tolbutamide results in increased expression of SLC2A1 mRNA; Tolbutamide results in increased expression of SLC2A1 protein CTD PMID:2682625 PMID:11835228 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP Tolbutamide results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 decreases expression EXP Tolbutamide results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314
JBrowse link
G TP53 tumor protein p53 increases expression ISO Tolbutamide results in increased expression of TP53 mRNA CTD PMID:16426753 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TPD52 tumor protein D52 decreases expression
increases expression
EXP Tolbutamide results in decreased expression of TPD52 mRNA
Tolbutamide results in increased expression of TPD52 mRNA
CTD PMID:21873647 NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase decreases expression ISO Tolbutamide results in decreased expression of UGDH protein CTD PMID:4270849 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases expression ISO Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 affects expression ISO Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 affects metabolic processing ISO CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions
increases metabolic processing
EXP Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]
CYP2C8 protein results in increased metabolism of Torsemide
CTD PMID:15304522 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases hydroxylation
increases metabolic processing
EXP CYP2C9 protein results in increased hydroxylation of Torsemide
CYP2C9 protein results in increased metabolism of Torsemide
CTD PMID:9110362 PMID:19082874 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G NPPA natriuretic peptide A decreases expression ISO Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions ISO Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G REN renin increases expression ISO Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC12A2 solute carrier family 12 member 2 multiple interactions
decreases activity
EXP Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Torsemide results in decreased activity of SLC12A2 protein
CTD PMID:29959396 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
G TGFB1 transforming growth factor beta 1 affects expression
decreases expression
ISO Torsemide affects the expression of TGFB1 protein
Torsemide results in decreased expression of TGFB1 protein
CTD PMID:18001696 PMID:18154949 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
triflusulfuron-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions EXP [prochloraz co-treated with Chlorpyrifos co-treated with triflusulfuron-methyl] results in increased expression of CYP19A1 mRNA CTD PMID:25233012 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26827
    role 26655
      application 25676
        agrochemical 18593
          fertilizer 16201
            urea 6502
              ureas 6500
                N-sulfonylurea 150
                  1-(4-chlorobenzenesulfonyl)-3-(2-oxopropyl)urea 0
                  3-[(2-adamantylamino)-oxomethyl]-1-methylsulfonyl-1-pentylurea 0
                  3-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-4-(5-methyl-5,6-dihydro-1,4,2-dioxazin-3-yl)-1H-pyrazole-5-sulfonamide + 0
                  4'-hydroxy torasemide 0
                  5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}-2-hydroxypropyl)-2-methoxybenzamide 0
                  5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}propyl)-2-methoxybenzamide 0
                  Cinosulfuron 0
                  MCC950 0
                  acetohexamide 2
                  azimsulfuron 0
                  bensulfuron + 1
                  bensulfuron-methyl 1
                  chlorimuron + 0
                  chlorimuron-ethyl 0
                  chlorimuron-ethyl(1-) 0
                  chlorpropamide 6
                  chlorsulfuron 0
                  ethametsulfuron + 0
                  ethametsulfuron-methyl 0
                  flucarbazone 0
                  gliclazide 33
                  glimepiride 18
                  glipizide 5
                  glyburide 106
                  hydroxy torasemide 0
                  iofensulfuron 0
                  metsulfuron methyl 2
                  nicosulfuron 0
                  orthosulfamuron 0
                  rimsulfuron 0
                  sulfometuron + 0
                  sulfometuron methyl 0
                  thiencarbazone + 0
                  thiencarbazone-methyl 0
                  thifensulfuron + 0
                  thifensulfuron-methyl 0
                  tolazamide 1
                  tolbutamide 27
                  torasemide + 10
                  torasemide carboxylic acid 0
                  triasulfuron 0
                  tribenuron + 0
                  tribenuron methyl 0
                  triflusulfuron + 1
                  triflusulfuron-methyl 1
                  tritosulfuron 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26827
    subatomic particle 26803
      composite particle 26803
        hadron 26803
          baryon 26803
            nucleon 26803
              atomic nucleus 26803
                atom 26803
                  main group element atom 26554
                    p-block element atom 26554
                      carbon group element atom 26035
                        carbon atom 25998
                          organic molecular entity 25998
                            heteroorganic entity 25379
                              organochalcogen compound 24991
                                organooxygen compound 24621
                                  carbon oxoacid 22985
                                    carboxylic acid 22972
                                      carboacyl group 20181
                                        univalent carboacyl group 20181
                                          carbamoyl group 19703
                                            carboxamide 19703
                                              monocarboxylic acid amide 17095
                                                urea 6502
                                                  ureas 6500
                                                    N-sulfonylurea 150
                                                      1-(4-chlorobenzenesulfonyl)-3-(2-oxopropyl)urea 0
                                                      3-[(2-adamantylamino)-oxomethyl]-1-methylsulfonyl-1-pentylurea 0
                                                      3-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-4-(5-methyl-5,6-dihydro-1,4,2-dioxazin-3-yl)-1H-pyrazole-5-sulfonamide + 0
                                                      4'-hydroxy torasemide 0
                                                      5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}-2-hydroxypropyl)-2-methoxybenzamide 0
                                                      5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}propyl)-2-methoxybenzamide 0
                                                      Cinosulfuron 0
                                                      MCC950 0
                                                      acetohexamide 2
                                                      azimsulfuron 0
                                                      bensulfuron + 1
                                                      bensulfuron-methyl 1
                                                      chlorimuron + 0
                                                      chlorimuron-ethyl 0
                                                      chlorimuron-ethyl(1-) 0
                                                      chlorpropamide 6
                                                      chlorsulfuron 0
                                                      ethametsulfuron + 0
                                                      ethametsulfuron-methyl 0
                                                      flucarbazone 0
                                                      gliclazide 33
                                                      glimepiride 18
                                                      glipizide 5
                                                      glyburide 106
                                                      hydroxy torasemide 0
                                                      iofensulfuron 0
                                                      metsulfuron methyl 2
                                                      nicosulfuron 0
                                                      orthosulfamuron 0
                                                      rimsulfuron 0
                                                      sulfometuron + 0
                                                      sulfometuron methyl 0
                                                      thiencarbazone + 0
                                                      thiencarbazone-methyl 0
                                                      thifensulfuron + 0
                                                      thifensulfuron-methyl 0
                                                      tolazamide 1
                                                      tolbutamide 27
                                                      torasemide + 10
                                                      torasemide carboxylic acid 0
                                                      triasulfuron 0
                                                      tribenuron + 0
                                                      tribenuron methyl 0
                                                      triflusulfuron + 1
                                                      triflusulfuron-methyl 1
                                                      tritosulfuron 0
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