MRC1 (mannose receptor C-type 1) - Rat Genome Database

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Gene: MRC1 (mannose receptor C-type 1) Homo sapiens
Analyze
Symbol: MRC1
Name: mannose receptor C-type 1
RGD ID: 1319655
HGNC Page HGNC:7228
Description: Enables cargo receptor activity. Involved in receptor-mediated endocytosis. Located in endosome membrane and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: bA541I19.1; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; CD206; CLEC13D; CLEC13DL; hMR; human mannose receptor; macrophage mannose receptor 1; macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; MGC181940; MMR; MRC1L1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: In the NCBI Build 37.2 reference assembly, MRC1 and MRC1L1 are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. Two of the clones on which MRC1L1 was based (AL928580, BX255924) will be removed from the reference assembly and only MRC1 will be present in the assembly. [13 Feb 2013]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381017,809,348 - 17,911,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1017,809,348 - 17,911,164 (+)EnsemblGRCh38hg38GRCh38
GRCh371018,098,337 - 18,200,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361018,138,358 - 18,240,097 (+)NCBINCBI36Build 36hg18NCBI36
Build 341018,138,357 - 18,240,096NCBI
Celera1017,784,841 - 17,886,612 (+)NCBICelera
Cytogenetic Map10p12.33NCBI
HuRef1017,764,080 - 17,866,209 (+)NCBIHuRef
CHM1_11018,109,965 - 18,199,387 (+)NCBICHM1_1
T2T-CHM13v2.01017,828,682 - 17,930,487 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
agathisflavone  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (EXP)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carveol  (ISO)
CGP 52608  (EXP)
choline  (ISO)
cocaine  (ISO)
corosolic acid  (ISO)
Cyclopamine  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
dichlorine  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
ethylparaben  (EXP)
etoposide  (ISO)
excitatory amino acid agonist  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
Gingerenone A  (ISO)
glyburide  (ISO)
Harpagide  (ISO)
HU-308  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
mechlorethamine  (ISO)
metformin  (ISO)
methidathion  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
Morroniside  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nevirapine  (ISO)
nickel atom  (EXP)
nickel subsulfide  (ISO)
nimesulide  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perindopril  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vinclozolin  (ISO)
WIN 55212-2  (ISO)
zinc sulfate  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IEA)
endosome  (IEA)
endosome membrane  (IDA,IEA)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
tuberculosis pathway  (IEA)

External Pathway Database Links

KEGG Pathway Phagosome
Tuberculosis

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
5. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:1294118   PMID:1730714   PMID:2258707   PMID:2373685   PMID:3611070   PMID:8001982   PMID:8940052   PMID:9038177   PMID:9677318   PMID:10779515   PMID:11120831   PMID:11222859  
PMID:11715017   PMID:11752456   PMID:11841552   PMID:12368450   PMID:12477932   PMID:14568928   PMID:15042510   PMID:15047828   PMID:15155616   PMID:15190005   PMID:15637102   PMID:15767290  
PMID:15955449   PMID:16000387   PMID:16203868   PMID:16385451   PMID:16547227   PMID:16615932   PMID:16672549   PMID:17020928   PMID:17077296   PMID:17255364   PMID:17360361   PMID:17502612  
PMID:18029348   PMID:18279703   PMID:18353434   PMID:19196802   PMID:19197942   PMID:19224860   PMID:19403625   PMID:19460752   PMID:19683778   PMID:19772890   PMID:19902202   PMID:20035344  
PMID:20139978   PMID:20554962   PMID:20610655   PMID:21029423   PMID:21331365   PMID:21416197   PMID:21873635   PMID:21922073   PMID:21943158   PMID:22132194   PMID:22289891   PMID:22314623  
PMID:22392581   PMID:22393309   PMID:22842622   PMID:22967244   PMID:23148569   PMID:23345393   PMID:23603511   PMID:23653008   PMID:23734186   PMID:23951013   PMID:24114918   PMID:24184555  
PMID:24498098   PMID:24969847   PMID:25057126   PMID:25146376   PMID:25182001   PMID:25614715   PMID:26169445   PMID:26202986   PMID:26209923   PMID:26352004   PMID:26352275   PMID:26682511  
PMID:26703454   PMID:27449998   PMID:27601670   PMID:27793384   PMID:27832191   PMID:28059035   PMID:28066953   PMID:28598681   PMID:28656201   PMID:29100978   PMID:29225077   PMID:29732570  
PMID:30021884   PMID:30177769   PMID:30521839   PMID:31143953   PMID:31242338   PMID:31491467   PMID:31822747   PMID:31825135   PMID:31982413   PMID:32690608   PMID:33192174   PMID:33545173  
PMID:34267749   PMID:34486997   PMID:34608184   PMID:34990410   PMID:36183584   PMID:36376784   PMID:37041007   PMID:38078733  


Genomics

Comparative Map Data
MRC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381017,809,348 - 17,911,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1017,809,348 - 17,911,164 (+)EnsemblGRCh38hg38GRCh38
GRCh371018,098,337 - 18,200,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361018,138,358 - 18,240,097 (+)NCBINCBI36Build 36hg18NCBI36
Build 341018,138,357 - 18,240,096NCBI
Celera1017,784,841 - 17,886,612 (+)NCBICelera
Cytogenetic Map10p12.33NCBI
HuRef1017,764,080 - 17,866,209 (+)NCBIHuRef
CHM1_11018,109,965 - 18,199,387 (+)NCBICHM1_1
T2T-CHM13v2.01017,828,682 - 17,930,487 (+)NCBIT2T-CHM13v2.0
Mrc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39214,234,225 - 14,336,834 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl214,234,203 - 14,336,868 (+)EnsemblGRCm39 Ensembl
GRCm38214,229,414 - 14,332,023 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl214,229,392 - 14,332,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv37214,151,041 - 14,253,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36214,147,168 - 14,249,543 (+)NCBIMGSCv36mm8
Celera214,132,507 - 14,234,218 (+)NCBICelera
Cytogenetic Map2A2NCBI
cM Map210.46NCBI
Mrc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81782,157,725 - 82,239,411 (+)NCBIGRCr8
mRatBN7.21777,249,187 - 77,330,857 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,249,187 - 77,330,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1780,698,196 - 80,779,156 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01784,533,598 - 84,614,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01778,581,501 - 78,662,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01781,352,700 - 81,433,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,352,700 - 81,433,743 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01783,099,574 - 83,180,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,411,265 - 88,492,622 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11788,422,190 - 88,503,040 (+)NCBI
Celera1776,583,460 - 76,664,122 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Mrc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542910,139,355 - 10,232,600 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542910,139,398 - 10,232,541 (-)NCBIChiLan1.0ChiLan1.0
MRC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2830,653,624 - 30,756,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11030,658,945 - 30,761,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01018,128,280 - 18,230,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11018,398,310 - 18,500,367 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1018,398,310 - 18,500,367 (+)Ensemblpanpan1.1panPan2
MRC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1219,090,580 - 19,185,943 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl219,069,120 - 19,185,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,192,173 - 16,287,442 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0219,382,161 - 19,474,894 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl219,382,822 - 19,474,835 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,582,950 - 16,678,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0217,418,222 - 17,513,475 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0218,038,475 - 18,133,728 (-)NCBIUU_Cfam_GSD_1.0
Mrc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934418,413,121 - 18,497,481 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365209,463,007 - 9,547,257 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365209,463,007 - 9,547,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1044,107,072 - 44,226,733 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11044,107,926 - 44,226,734 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21048,841,154 - 48,960,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1917,751,053 - 17,849,258 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl917,751,133 - 17,849,406 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605123,397,347 - 23,496,696 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479610,145,610 - 10,180,671 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla_female_1.0 EnsemblNW_00462479610,040,859 - 10,138,420 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479610,041,483 - 10,184,458 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MRC1
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002438.4(MRC1):c.1186G>A (p.Gly396Ser) single nucleotide variant Leprosy, susceptibility to, 1 [RCV002291554]|Susceptibility to leprosy and multibacillary leprosy [RCV000054833] Chr10:17849701 [GRCh38]
Chr10:18138630 [GRCh37]
Chr10:10p12.33
risk factor|uncertain risk allele
GRCh38/hg38 10p12.33(chr10:17839748-17920896)x3 copy number gain See cases [RCV000134387] Chr10:17839748..17920896 [GRCh38]
Chr10:17809523..17962915 [GRCh37]
Chr10:17849529..18002921 [NCBI36]
Chr10:10p12.33
benign
GRCh38/hg38 10p12.33(chr10:17767524-17839747)x3 copy number gain See cases [RCV000134394] Chr10:17767524..17839747 [GRCh38]
Chr10:17809523..17892239 [GRCh37]
Chr10:17849529..17932245 [NCBI36]
Chr10:10p12.33
likely benign
GRCh38/hg38 10p12.33(chr10:17767524-17839747)x1 copy number loss See cases [RCV000134395] Chr10:17767524..17839747 [GRCh38]
Chr10:17809523..17892239 [GRCh37]
Chr10:10p12.33
conflicting data from submitters
GRCh38/hg38 10p14-12.31(chr10:7428770-21587752)x1 copy number loss See cases [RCV000137307] Chr10:7428770..21587752 [GRCh38]
Chr10:7470732..21876681 [GRCh37]
Chr10:7510738..21916687 [NCBI36]
Chr10:10p14-12.31
pathogenic|uncertain significance
GRCh38/hg38 10p12.33(chr10:17632287-17934423)x1 copy number loss See cases [RCV000137899] Chr10:17632287..17934423 [GRCh38]
Chr10:17714292..18263358 [NCBI36]
Chr10:10p12.33
likely benign
GRCh38/hg38 10p15.3-12.1(chr10:90205-26339978)x3 copy number gain See cases [RCV000138428] Chr10:90205..26339978 [GRCh38]
Chr10:224406..26628907 [GRCh37]
Chr10:126145..26668913 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22
benign
GRCh38/hg38 10p15.3-12.31(chr10:54086-19336980)x1 copy number loss See cases [RCV000143703] Chr10:54086..19336980 [GRCh38]
Chr10:100026..19625909 [GRCh37]
Chr10:90026..19665915 [NCBI36]
Chr10:10p15.3-12.31
pathogenic|likely pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:69261-19184047)x3 copy number gain See cases [RCV000053507] Chr10:69261..19184047 [GRCh38]
Chr10:224406..19472976 [GRCh37]
Chr10:105201..19512982 [NCBI36]
Chr10:10p15.3-12.31
pathogenic
GRCh38/hg38 10p15.3-12.2(chr10:90221-22567425)x3 copy number gain See cases [RCV000053508] Chr10:90221..22567425 [GRCh38]
Chr10:224406..22856354 [GRCh37]
Chr10:126161..22896360 [NCBI36]
Chr10:10p15.3-12.2
pathogenic
GRCh38/hg38 10p15.3-12.1(chr10:90421-29058318)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|See cases [RCV000053512] Chr10:90421..29058318 [GRCh38]
Chr10:224406..29347247 [GRCh37]
Chr10:126361..29387253 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
NM_002438.4(MRC1):c.744A>G (p.Gln248=) single nucleotide variant not provided [RCV003417249] Chr10:17833781 [GRCh38]
Chr10:17875780 [GRCh37]
Chr10:10p12.33
likely benign
NM_002438.4(MRC1):c.1110C>T (p.Ala370=) single nucleotide variant not provided [RCV003417251] Chr10:17849625 [GRCh38]
Chr10:18138554 [GRCh37]
Chr10:10p12.33
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:252
Count of miRNA genes:213
Interacting mature miRNAs:233
Transcripts:ENST00000239761
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH11113  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,145,116 - 18,145,377UniSTSGRCh37
GRCh371017,898,197 - 17,898,458UniSTSGRCh37
Build 361017,938,203 - 17,938,464RGDNCBI36
Celera1017,831,630 - 17,831,891RGD
Cytogenetic Map10p12.33UniSTS
HuRef1017,811,193 - 17,811,454UniSTS
GeneMap99-GB4 RH Map10114.6UniSTS
NCBI RH Map10228.7UniSTS
RH121281  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,151,440 - 18,151,783UniSTSGRCh37
GRCh371017,904,521 - 17,904,864UniSTSGRCh37
Build 361017,944,527 - 17,944,870RGDNCBI36
Celera1017,837,954 - 17,838,297RGD
Cytogenetic Map10p12.33UniSTS
HuRef1017,817,517 - 17,817,860UniSTS
MRC1_1326  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,199,457 - 18,200,227UniSTSGRCh37
GRCh371017,952,544 - 17,953,314UniSTSGRCh37
Build 361017,992,550 - 17,993,320RGDNCBI36
Celera1017,885,978 - 17,886,748RGD
HuRef1017,865,575 - 17,866,345UniSTS
D10S2285  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,199,537 - 18,199,875UniSTSGRCh37
GRCh371017,952,624 - 17,952,962UniSTSGRCh37
Build 361017,992,630 - 17,992,968RGDNCBI36
Celera1017,886,058 - 17,886,396RGD
Cytogenetic Map10p12.33UniSTS
HuRef1017,865,655 - 17,865,993UniSTS
Stanford-G3 RH Map10841.0UniSTS
Whitehead-YAC Contig Map10 UniSTS
NCBI RH Map10240.4UniSTS
GeneMap99-G3 RH Map10841.0UniSTS
RH11193  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371017,952,889 - 17,953,038UniSTSGRCh37
Build 361017,992,895 - 17,993,044RGDNCBI36
Celera1017,886,323 - 17,886,472RGD
Cytogenetic Map10p12.33UniSTS
HuRef1017,865,920 - 17,866,069UniSTS
GeneMap99-GB4 RH Map10115.15UniSTS
NCBI RH Map10229.8UniSTS
STS-J05550  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,199,680 - 18,199,805UniSTSGRCh37
GRCh371017,952,767 - 17,952,892UniSTSGRCh37
Build 361017,992,773 - 17,992,898RGDNCBI36
Celera1017,886,201 - 17,886,326RGD
Cytogenetic Map10p12.33UniSTS
HuRef1017,865,798 - 17,865,923UniSTS
GeneMap99-GB4 RH Map10114.6UniSTS
NCBI RH Map10228.7UniSTS
STS-U10408  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,098,245 - 18,098,371UniSTSGRCh37
GRCh371017,851,255 - 17,851,381UniSTSGRCh37
Build 361017,891,261 - 17,891,387RGDNCBI36
Celera1017,784,734 - 17,784,860RGD
Cytogenetic Map10p12.33UniSTS
GeneMap99-GB4 RH Map10115.15UniSTS
RH11114  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371018,196,453 - 18,196,660UniSTSGRCh37
GRCh371017,949,540 - 17,949,747UniSTSGRCh37
Build 361017,989,546 - 17,989,753RGDNCBI36
Celera1017,882,974 - 17,883,181RGD
Cytogenetic Map10p12.33UniSTS
HuRef1017,862,571 - 17,862,778UniSTS
GeneMap99-GB4 RH Map10115.15UniSTS
NCBI RH Map10249.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1043 795 585 155 414 114 1312 462 359 37 204 844 42 1091 637 2
Low 1188 1807 868 257 519 139 2579 1454 2053 94 948 408 118 113 1995
Below cutoff 37 378 12 9 396 9 346 246 1199 17 42 78 7 156 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV659122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC142642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU198859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX255924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC296466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ663787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF444997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000569591   ⟹   ENSP00000455897
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1017,809,348 - 17,911,164 (+)Ensembl
RefSeq Acc Id: NM_002438   ⟹   NP_002429
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,809,348 - 17,911,164 (+)NCBI
GRCh371018,098,332 - 18,200,091 (+)NCBI
GRCh371017,851,251 - 17,953,180 (+)NCBI
Build 361018,138,358 - 18,240,097 (+)NCBI Archive
HuRef1017,764,080 - 17,866,209 (+)NCBI
CHM1_11017,851,292 - 17,953,118 (+)NCBI
T2T-CHM13v2.01017,828,682 - 17,930,487 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002429   ⟸   NM_002438
- Peptide Label: precursor
- UniProtKB: Q5VSJ2 (UniProtKB/Swiss-Prot),   A5PKW3 (UniProtKB/Swiss-Prot),   Q5VSK2 (UniProtKB/Swiss-Prot),   P22897 (UniProtKB/Swiss-Prot),   Q0Z8D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000455897   ⟸   ENST00000569591
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22897-F1-model_v2 AlphaFold P22897 1-1456 view protein structure

Promoters
RGD ID:7217099
Promoter ID:EPDNEW_H14295
Type:initiation region
Name:MRC1_2
Description:mannose receptor C-type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14294  EPDNEW_H14296  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,809,155 - 17,809,215EPDNEW
RGD ID:7217101
Promoter ID:EPDNEW_H14296
Type:multiple initiation site
Name:MRC1_1
Description:mannose receptor C-type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14294  EPDNEW_H14295  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381017,809,348 - 17,809,408EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7228 AgrOrtholog
COSMIC MRC1 COSMIC
Ensembl Genes ENSG00000260314 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000569591 ENTREZGENE
  ENST00000569591.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000260314 GTEx
HGNC ID HGNC:7228 ENTREZGENE
Human Proteome Map MRC1 Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ricin_B-like_lectins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4360 UniProtKB/Swiss-Prot
NCBI Gene 4360 ENTREZGENE
OMIM 153618 OMIM
PANTHER MACROPHAGE MANNOSE RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ricin_B_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30933 PharmGKB
PRINTS FNTYPEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RICIN_B_LECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RICIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A5PKW3 ENTREZGENE
  B9EJA8_HUMAN UniProtKB/TrEMBL
  L8E7Q9_HUMAN UniProtKB/TrEMBL
  MRC1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q0Z8D6 ENTREZGENE, UniProtKB/TrEMBL
  Q5VSJ2 ENTREZGENE
  Q5VSK2 ENTREZGENE
UniProt Secondary A5PKW3 UniProtKB/Swiss-Prot
  Q5VSJ2 UniProtKB/Swiss-Prot
  Q5VSK2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-06 MRC1  mannose receptor C-type 1    mannose receptor, C type 1  Symbol and/or name change 5135510 APPROVED
2016-03-29 MRC1  mannose receptor, C type 1  MRC1L1  mannose receptor, C type 1-like 1  Data merged from RGD:1345928 737654 PROVISIONAL