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Gene: MBP (myelin basic protein) Homo sapiens
Symbol: MBP
Name: myelin basic protein
Description: Exhibits calmodulin binding activity. Involved in several processes, including maintenance of permeability of blood-brain barrier; negative regulation of heterotypic cell-cell adhesion; and positive regulation of cytokine secretion. Localizes to the myelin sheath and protein-containing complex. Implicated in multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Golli-MBP; MGC99675; myelin A1 protein; myelin membrane encephalitogenic protein; proline-rich proteoglycan 2
Mus musculus (house mouse) : Mbp (myelin basic protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mbp (myelin basic protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mbp (myelin basic protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MBP (myelin basic protein)
Canis lupus familiaris (dog) : MBP (myelin basic protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mbp (myelin basic protein)
Sus scrofa (pig) : MBP (myelin basic protein)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   MULTSCL1_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MBP (Gene ID: 4155) and MBL2 (Gene ID: 4153) share the MBP symbol/alias in common. MBP is a widely used alternative name for mannose binding lectin 2 (MBL2), which can be confused with the official symbol for MBP (myelin basic protein, GeneID 4155). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381876,978,833 - 77,133,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371874,690,789 - 74,844,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361872,819,777 - 72,973,762 (-)NCBINCBI36hg18NCBI36
Build 341872,820,710 - 72,857,962NCBI
Celera1871,507,828 - 71,661,692 (-)NCBI
Cytogenetic Map18q23NCBI
HuRef1871,371,431 - 71,525,606 (-)NCBIHuRef
CHM1_11874,686,498 - 74,841,139 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MBP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736262
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.