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Gene: MBP (myelin basic protein) Homo sapiens
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Symbol: MBP
Name: myelin basic protein
Description: Exhibits calmodulin binding activity. Involved in several processes, including maintenance of permeability of blood-brain barrier; negative regulation of heterotypic cell-cell adhesion; and positive regulation of cytokine secretion. Localizes to the myelin sheath and protein-containing complex. Implicated in multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Golli-MBP; MGC99675; myelin A1 protein; myelin membrane encephalitogenic protein; proline-rich proteoglycan 2
Orthologs:
Mus musculus (house mouse) : Mbp (myelin basic protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mbp (myelin basic protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mbp (myelin basic protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MBP (myelin basic protein)
Canis lupus familiaris (dog) : MBP (myelin basic protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mbp (myelin basic protein)
Sus scrofa (pig) : MBP (myelin basic protein)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   MULTSCL1_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MBP (Gene ID: 4155) and MBL2 (Gene ID: 4153) share the MBP symbol/alias in common. MBP is a widely used alternative name for mannose binding lectin 2 (MBL2), which can be confused with the official symbol for MBP (myelin basic protein, GeneID 4155). [01 Jun 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381876,978,833 - 77,133,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371874,690,789 - 74,844,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361872,819,777 - 72,973,762 (-)NCBINCBI36hg18NCBI36
Build 341872,820,710 - 72,857,962NCBI
Celera1871,507,828 - 71,661,692 (-)NCBI
Cytogenetic Map18q23NCBI
HuRef1871,371,431 - 71,525,606 (-)NCBIHuRef
CHM1_11874,686,498 - 74,841,139 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MBP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736262
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.