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Gene: IRS2 (insulin receptor substrate 2) Homo sapiens
Symbol: IRS2
Name: insulin receptor substrate 2
Description: Predicted to have insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to insulin stimulus; positive regulation of small molecule metabolic process; and regulation of transmembrane transport. Predicted to localize to the cytosol and plasma membrane. Implicated in type 2 diabetes mellitus. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IRS-2
Mus musculus (house mouse) : Irs2 (insulin receptor substrate 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irs2 (insulin receptor substrate 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs2 (insulin receptor substrate 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS2 (insulin receptor substrate 2)
Canis lupus familiaris (dog) : IRS2 (insulin receptor substrate 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs2 (insulin receptor substrate 2)
Sus scrofa (pig) : IRS2 (insulin receptor substrate 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl13109,752,695 - 109,786,583 (-)Ensembl
GRCh3813109,752,695 - 109,786,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713110,406,184 - 110,438,914 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613109,204,185 - 109,236,915 (-)NCBINCBI36hg18NCBI36
Build 3413109,204,186 - 109,236,915NCBI
Celera1391,250,464 - 91,283,200 (-)NCBI
Cytogenetic Map13q34NCBI
HuRef1391,005,522 - 91,037,072 (-)NCBIHuRef
CHM1_113110,375,378 - 110,407,600 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRS2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736204
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.