INSR (insulin receptor) - Rat Genome Database
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Gene: INSR (insulin receptor) Homo sapiens
Symbol: INSR
Name: insulin receptor
RGD ID: 69029
Description: Exhibits several functions, including insulin-like growth factor binding activity; peptide binding activity; and purine ribonucleoside triphosphate binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of glucose import; and protein phosphorylation. Localizes to caveola and insulin receptor complex. Colocalizes with nuclear envelope and nuclear lumen. Implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Biomarker of Alzheimer's disease; breast cancer; hepatocellular carcinoma; renal cell carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD220; HHF5; IR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl197,112,255 - 7,294,414 (-)EnsemblGRCh38hg38GRCh38
GRCh38197,112,257 - 7,294,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,112,266 - 7,294,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,063,266 - 7,245,011 (-)NCBINCBI36hg18NCBI36
Build 34197,067,637 - 7,245,011NCBI
Celera197,049,684 - 7,205,258 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef196,846,024 - 7,028,322 (-)NCBIHuRef
CHM1_1197,111,894 - 7,294,726 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxan  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
AP20187  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP)
benzoic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
dipyridamole  (EXP)
doxorubicin  (EXP)
duvoglustat  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
glucose  (EXP,ISO)
hexachlorobenzene  (EXP,ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
isoliquiritigenin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
magnesium atom  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
molybdate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel atom  (EXP,ISO)
nicotine  (ISO)
nitrofen  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP)
orientin  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylarsine oxide  (ISO)
phenytoin  (EXP)
picolinic acid  (ISO)
potassium chromate  (EXP)
progesterone  (EXP,ISO)
puerarin  (ISO)
quercetin  (ISO)
quercitrin  (EXP)
raffinose  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rutamarin  (ISO)
rutin  (ISO)
SB 203580  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP)
taurine  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
thiazolidines  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vildagliptin  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (IMP)
activation of protein kinase activity  (IMP)
activation of protein kinase B activity  (IDA)
adrenal gland development  (ISO)
alternative mRNA splicing, via spliceosome  (ISO)
amyloid-beta clearance  (ISS)
animal organ morphogenesis  (ISO)
carbohydrate metabolic process  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to insulin stimulus  (IDA)
cerebellum development  (ISO)
dendritic spine maintenance  (ISS)
embryonic liver development  (ISO)
epidermis development  (ISO)
exocrine pancreas development  (ISO)
fat cell differentiation  (ISO)
G protein-coupled receptor signaling pathway  (IDA)
glucose homeostasis  (IBA,IMP)
heart morphogenesis  (IMP)
hippocampus development  (ISO)
insulin receptor signaling pathway  (IDA,ISS,TAS)
learning  (TAS)
liver development  (ISO)
liver regeneration  (ISO)
male gonad development  (ISO)
male sex determination  (ISO)
memory  (TAS)
multicellular organism development  (IBA)
negative regulation of feeding behavior  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of transporter activity  (ISO)
neuron projection maintenance  (ISS)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IC,IDA,IMP)
positive regulation of developmental growth  (IMP)
positive regulation of glucose import  (IDA,NAS)
positive regulation of glycogen biosynthetic process  (IDA)
positive regulation of glycolytic process  (IMP)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA,IDA,IMP)
positive regulation of meiotic cell cycle  (ISO)
positive regulation of mitotic nuclear division  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (IBA,IMP)
positive regulation of protein phosphorylation  (IDA)
positive regulation of protein-containing complex disassembly  (ISS)
positive regulation of receptor internalization  (IDA)
positive regulation of respiratory burst  (IDA)
positive regulation of transcription, DNA-templated  (ISO)
protein autophosphorylation  (IDA,IMP)
protein phosphorylation  (TAS)
receptor-mediated endocytosis  (ISS)
regulation of embryonic development  (IMP)
regulation of female gonad development  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of hydrogen peroxide metabolic process  (ISO)
regulation of transcription, DNA-templated  (IMP)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to manganese ion  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to resveratrol  (ISO)
response to testosterone  (ISO)
response to tumor necrosis factor  (ISO)
response to vanadate(3-)  (ISO)
response to vitamin D  (ISO)
transformation of host cell by virus  (IMP)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
transport across blood-brain barrier  (NAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal distention  (IAGP)
Abnormal C-peptide level  (IAGP)
Abnormality of the abdominal wall  (IAGP)
Acanthosis nigricans  (IAGP)
Accelerated skeletal maturation  (IAGP)
Adipose tissue loss  (IAGP)
Advanced eruption of teeth  (IAGP)
Anteverted nares  (IAGP)
Atrial septal defect  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Cardiomyopathy  (IAGP)
Central hypothyroidism  (IAGP)
Cholestasis  (IAGP)
Clitoral hypertrophy  (IAGP)
CNS demyelination  (IAGP)
Coarse facial features  (IAGP)
Coma  (IAGP)
Delayed puberty  (IAGP)
Delayed skeletal maturation  (IAGP)
Dental crowding  (IAGP)
Diabetic ketoacidosis  (IAGP)
Dry skin  (IAGP)
Elfin facies  (IAGP)
Enlarged kidney  (IAGP)
Enlarged ovaries  (IAGP)
Facial hypertrichosis  (IAGP)
Failure to thrive  (IAGP)
Fasting hyperinsulinemia  (IAGP)
Fasting hypoglycemia  (IAGP)
Fatigue  (IAGP)
Furrowed tongue  (IAGP)
Generalized hirsutism  (IAGP)
Generalized hyperpigmentation  (IAGP)
Gingival overgrowth  (IAGP)
Global developmental delay  (IAGP)
Hepatic fibrosis  (IAGP)
Hepatomegaly  (IAGP)
Heterogeneous  (IAGP)
High palate  (IAGP)
Hirsutism  (IAGP)
Hyperaldosteronism  (IAGP)
Hypercalciuria  (IAGP)
Hyperextensible skin  (IAGP)
Hyperglycemia  (IAGP)
Hyperinsulinemia  (IAGP)
Hyperinsulinemic hypoglycemia  (IAGP)
Hyperkeratosis  (IAGP)
Hypermelanotic macule  (IAGP)
Hypertelorism  (IAGP)
Hypertrichosis  (IAGP)
Hypertrophic cardiomyopathy  (IAGP)
Hypoglycemic coma  (IAGP)
Hypoglycemic seizures  (IAGP)
Hypokalemia  (IAGP)
Hypothyroidism  (IAGP)
Impaired glucose tolerance  (IAGP)
Increased C-peptide level  (IAGP)
Increased circulating renin level  (IAGP)
Increased pineal volume  (IAGP)
Increased serum testosterone level  (IAGP)
Insulin resistance  (IAGP)
Insulin-resistant diabetes mellitus  (IAGP)
Intellectual disability  (IAGP)
Intrauterine growth retardation  (IAGP)
Labial hypertrophy  (IAGP)
Large hands  (IAGP)
Lichenoid skin lesion  (IAGP)
Long foot  (IAGP)
Long penis  (IAGP)
Low anterior hairline  (IAGP)
Low-set ears  (IAGP)
Macroglossia  (IAGP)
Macrotia  (IAGP)
Mandibular prognathia  (IAGP)
Megarectum  (IAGP)
Microcephaly  (IAGP)
Muscular hypotonia of the trunk  (IAGP)
Nail dysplasia  (IAGP)
Nephrocalcinosis  (IAGP)
Onychauxis  (IAGP)
Ovarian cyst  (IAGP)
Overgrowth of external genitalia  (IAGP)
Pancreatic islet-cell hyperplasia  (IAGP)
Peripheral neuropathy  (IAGP)
Pointed chin  (IAGP)
Polydactyly  (IAGP)
Polydipsia  (IAGP)
Postnatal growth retardation  (IAGP)
Postprandial hyperglycemia  (IAGP)
Precocious puberty  (IAGP)
Premature graying of hair  (IAGP)
Prominent nasal bridge  (IAGP)
Prominent nipples  (IAGP)
Proptosis  (IAGP)
Protruding ear  (IAGP)
Rectal prolapse  (IAGP)
Recurrent hypoglycemia  (IAGP)
Recurrent infantile hypoglycemia  (IAGP)
Recurrent infections  (IAGP)
Reduced subcutaneous adipose tissue  (IAGP)
Retinopathy  (IAGP)
Seizure  (IAGP)
Severe failure to thrive  (IAGP)
Severe global developmental delay  (IAGP)
Severe intrauterine growth retardation  (IAGP)
Severe postnatal growth retardation  (IAGP)
Short stature  (IAGP)
Skeletal muscle atrophy  (IAGP)
Small face  (IAGP)
Small for gestational age  (IAGP)
Subcutaneous nodule  (IAGP)
Thick hair  (IAGP)
Thick lower lip vermilion  (IAGP)
Thick vermilion border  (IAGP)
Type II diabetes mellitus  (IAGP)
Ventricular septal defect  (IAGP)
Wide mouth  (IAGP)
Wide nose  (IAGP)

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Additional References at PubMed
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PMID:1993068   PMID:2002058   PMID:2033070   PMID:2040394   PMID:2121734   PMID:2168397   PMID:2210055   PMID:2211730   PMID:2280779   PMID:2365819   PMID:2369896   PMID:2460770  
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PMID:7626603   PMID:7657032   PMID:7659087   PMID:7693131   PMID:7794689   PMID:7806540   PMID:7815442   PMID:7836419   PMID:7860063   PMID:7895674   PMID:7906861   PMID:7926007  
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