INSR (insulin receptor) - Rat Genome Database

Name: INSR
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: INSR (insulin receptor) Homo sapiens

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Symbol:

INSR

Name:

insulin receptor

RGD ID:

69029

HGNC Page

HGNC:6091

Description:

Enables several functions, including insulin-like growth factor binding activity; peptide binding activity; and purine ribonucleoside triphosphate binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in caveola. Part of insulin receptor complex. Colocalizes with nuclear envelope and nuclear lumen. Implicated in Donohue syndrome; glucose metabolism disease (multiple); and reproductive organ cancer (multiple). Biomarker of Alzheimer's disease; breast cancer; hepatocellular carcinoma; renal cell carcinoma; and seminoma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

CD220; HHF5; IR

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Insr (insulin receptor)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Insr (insulin receptor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Chinchilla lanigera (long-tailed chinchilla):	Insr (insulin receptor)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	INSR (insulin receptor)	NCBI	Ortholog
Canis lupus familiaris (dog):	INSR (insulin receptor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Insr (insulin receptor)	NCBI	Ortholog
Sus scrofa (pig):	INSR (insulin receptor)	HGNC	EggNOG, Ensembl, NCBI, OrthoDB
Chlorocebus sabaeus (green monkey):	INSR (insulin receptor)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Insr (insulin receptor)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Igf1r (insulin-like growth factor I receptor)	HGNC	OrthoMCL
Mus musculus (house mouse):	Insrr (insulin receptor-related receptor)	HGNC	OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Insr (insulin receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Insr (insulin receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	insrb (insulin receptor b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	insra (insulin receptor a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	daf-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	InR	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	insr.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	insr	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	insr.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	7,112,265 - 7,294,414 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	7,112,255 - 7,294,414 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	7,112,276 - 7,294,425 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	7,063,266 - 7,245,011 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	7,067,637 - 7,245,011	NCBI
Celera	19	7,049,684 - 7,205,258 (-)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	6,846,024 - 7,028,322 (-)	NCBI		HuRef
CHM1_1	19	7,111,894 - 7,294,424 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	7,103,362 - 7,286,608 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Imported Human Phenotype Annotations - HPO

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