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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:enzalutamide
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Accession:CHEBI:68534 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.
Synonyms:exact_synonym: 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluoro-N-methylbenzamide
 related_synonym: Formula=C21H16F4N4O2S;   InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30);   InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N;   MDV 3100;   MDV3100;   SMILES=CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F;   XTANDI
 xref: CAS:915087-33-1;   Drug_Central:4628;   LINCS:LSM-6254
 xref_mesh: MESH:C540278
 xref: PMID:21986558;   PMID:22101903;   PMID:22113551;   PMID:22162475;   PMID:22229405;   PMID:22258371;   PMID:22258374;   PMID:22266222;   PMID:22310230;   PMID:22373838;   PMID:22393799;   PMID:22411952;   PMID:22429837;   PMID:22472508;   PMID:22516457;   PMID:22710436;   PMID:22815001;   PMID:22845410;   PMID:22852027;   PMID:22894553;   PMID:22956944;   PMID:22985411;   PMID:22987974;   Patent:US2007254933;   Patent:WO2006124118;   Patent:WO2011106570;   Reaxys:11718700;   Wikipedia:Enzalutamide


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enzalutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression ISO enzalutamide results in decreased expression of AADAT mRNA CTD PMID:29581250 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO enzalutamide results in decreased expression of ABCC4 mRNA CTD PMID:29581250 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO enzalutamide results in decreased expression of ACSM1 mRNA CTD PMID:29581250 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 affects expression ISO enzalutamide affects the expression of ADAM10 mRNA CTD PMID:30940724 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 affects expression ISO enzalutamide affects the expression of ADAM17 mRNA CTD PMID:30940724 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent decreases expression ISO enzalutamide results in decreased expression of ADPRM mRNA CTD PMID:29581250 NCBI chr10:51,732,073...51,744,635
Ensembl chr10:51,731,993...51,744,635 		JBrowse link
G Aff3 ALF transcription elongation factor 3 decreases expression ISO enzalutamide results in decreased expression of AFF3 mRNA CTD PMID:29581250 NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO enzalutamide results in decreased expression of ALDH1A3 mRNA CTD PMID:29581250 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Alpk2 alpha-kinase 2 decreases expression ISO enzalutamide results in decreased expression of ALPK2 mRNA CTD PMID:29581250 NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258 		JBrowse link
G Anxa4 annexin A4 affects expression ISO enzalutamide affects the expression of ANXA4 mRNA CTD PMID:30940724 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit affects expression ISO enzalutamide affects the expression of APH1A mRNA CTD PMID:30940724 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit affects expression ISO enzalutamide affects the expression of APH1B mRNA CTD PMID:30940724 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G App amyloid beta precursor protein affects expression ISO enzalutamide affects the expression of APP mRNA CTD PMID:30940724 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
decreases response to substance
decreases activity		 ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA alternative form; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein alternative form; [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of AR protein; enzalutamide binds to and results in decreased localization of and results in decreased activity of AR protein; enzalutamide inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; enzalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]
enzalutamide results in decreased expression of AR protein; enzalutamide results in decreased expression of AR protein alternative form
AR alternative form results in decreased susceptibility to enzalutamide; AR protein alternative form results in decreased susceptibility to enzalutamide; AR protein results in decreased susceptibility to enzalutamide
enzalutamide results in decreased activity of AR protein		 CTD PMID:19359544 PMID:24740322 PMID:24759320 PMID:25908785 PMID:25970160 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding decreases expression ISO enzalutamide results in decreased expression of AZGP1 mRNA CTD PMID:29581250 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein] CTD PMID:25970160 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO enzalutamide results in decreased expression of BMPR1B mRNA CTD PMID:29581250 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368 		JBrowse link
G C13h1orf116 similar to human chromosome 1 open reading frame 116 decreases expression ISO enzalutamide results in decreased expression of C1ORF116 mRNA CTD PMID:29581250 NCBI chr13:42,187,442...42,201,432
Ensembl chr13:42,188,609...42,201,426 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of CASP3 protein]
enzalutamide results in decreased expression of CASP3 protein		 CTD PMID:32184358 PMID:32805266 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO enzalutamide results in decreased expression of CASP8 protein CTD PMID:32805266 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO enzalutamide results in decreased expression of CCNB1 protein CTD PMID:32805266 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd46 CD46 molecule increases expression ISO enzalutamide results in increased expression of CD46 protein CTD PMID:30185663 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C protein CTD PMID:32184358 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO enzalutamide affects the expression of CDKN1B mRNA CTD PMID:30940724 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO enzalutamide affects the expression of CEBPA mRNA CTD PMID:30940724 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases activity
multiple interactions		 ISO enzalutamide results in decreased activity of CFLAR protein
enzalutamide promotes the reaction [lupeol results in decreased activity of CFLAR protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of CFLAR protein]		 CTD PMID:37777120 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Crebbp CREB binding protein affects expression ISO enzalutamide affects the expression of CREBBP mRNA CTD PMID:30940724 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Crisp3 cysteine-rich secretory protein 3 decreases expression ISO enzalutamide results in decreased expression of CRISP3 mRNA CTD PMID:29581250 NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658 		JBrowse link
G Crym crystallin, mu multiple interactions
decreases expression		 ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA] CTD PMID:29581250 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 decreases expression ISO enzalutamide results in decreased expression of CSGALNACT1 mRNA CTD PMID:29581250 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO enzalutamide results in decreased expression of DPP4 mRNA CTD PMID:29581250 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dtx2 deltex E3 ubiquitin ligase 2 affects expression ISO enzalutamide affects the expression of DTX2 mRNA CTD PMID:30940724 NCBI chr12:20,643,289...20,682,908
Ensembl chr12:20,643,297...20,682,885 		JBrowse link
G Dtx3 deltex E3 ubiquitin ligase 3 affects expression ISO enzalutamide affects the expression of DTX3 mRNA CTD PMID:30940724 NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 affects expression ISO enzalutamide affects the expression of DTX4 mRNA CTD PMID:30940724 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818 		JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 decreases expression ISO enzalutamide results in decreased expression of EDEM3 mRNA CTD PMID:29581250 NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523 		JBrowse link
G Eed embryonic ectoderm development multiple interactions
decreases expression		 ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of EED protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of EED protein] CTD PMID:32805266 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974 		JBrowse link
G Efcab12 EF-hand calcium binding domain 12 decreases expression ISO enzalutamide results in decreased expression of EFCAB12 mRNA CTD PMID:29581250 NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560 		JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 decreases expression ISO enzalutamide results in decreased expression of ELL2 mRNA CTD PMID:29581250 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781 		JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 decreases expression ISO enzalutamide results in decreased expression of ELOVL7 mRNA CTD PMID:29581250 NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845 		JBrowse link
G Ep300 E1A binding protein p300 affects expression ISO enzalutamide affects the expression of EP300 mRNA CTD PMID:30940724 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Ephb4 EPH receptor B4 affects response to substance
multiple interactions		 ISO EPHB4 protein affects the susceptibility to enzalutamide
enzalutamide promotes the reaction [EPHB4 protein affects the expression of KLK3 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]		 CTD PMID:32184358 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Epn1 Epsin 1 affects expression ISO enzalutamide affects the expression of EPN1 mRNA CTD PMID:30940724 NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression
multiple interactions		 ISO enzalutamide results in decreased expression of EZH2 protein
[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]		 CTD PMID:32805266 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression		 ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of FKBP5 mRNA; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of FKBP5 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of FKBP5 mRNA] CTD PMID:32184358 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Foxa1 forkhead box A1 affects expression ISO enzalutamide affects the expression of FOXA1 mRNA CTD PMID:30940724 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 affects expression ISO enzalutamide affects the expression of GALNT11 mRNA CTD PMID:30940724 NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase affects expression ISO enzalutamide affects the expression of GMDS mRNA CTD PMID:30940724 NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO enzalutamide results in decreased expression of GNMT mRNA CTD PMID:29581250 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression ISO enzalutamide affects the expression of GOT1 mRNA CTD PMID:30940724 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 decreases expression ISO enzalutamide results in decreased expression of GREB1 mRNA CTD PMID:29581250 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 affects expression ISO enzalutamide affects the expression of HES1 mRNA CTD PMID:30940724 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hnf1b HNF1 homeobox B affects expression ISO enzalutamide affects the expression of HNF1B mRNA CTD PMID:30940724 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888 		JBrowse link
G Ift172 intraflagellar transport 172 affects expression ISO enzalutamide affects the expression of IFT172 mRNA CTD PMID:30940724 NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860 		JBrowse link
G Ift74 intraflagellar transport 74 affects expression ISO enzalutamide affects the expression of IFT74 mRNA CTD PMID:30940724 NCBI chr 5:109,460,372...109,563,839
Ensembl chr 5:109,474,255...109,563,833 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO enzalutamide results in decreased expression of IGF1 mRNA CTD PMID:29581250 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO enzalutamide results in decreased expression of IGF1R mRNA CTD PMID:29581250 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases response to substance		 ISO Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide] CTD PMID:25970160 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 decreases expression ISO enzalutamide results in decreased expression of IQGAP2 mRNA CTD PMID:29581250 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase affects expression ISO enzalutamide affects the expression of ITCH mRNA CTD PMID:30940724 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 affects expression ISO enzalutamide affects the expression of ITGB1BP1 mRNA CTD PMID:30940724 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 affects expression ISO enzalutamide affects the expression of JAG1 mRNA CTD PMID:30940724 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 affects expression ISO enzalutamide affects the expression of JAG2 mRNA CTD PMID:30940724 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Kat2b lysine acetyltransferase 2B affects expression ISO enzalutamide affects the expression of KAT2B mRNA CTD PMID:30940724 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA] CTD PMID:29581250 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Kif5c kinesin family member 5C decreases expression ISO enzalutamide results in decreased expression of KIF5C mRNA CTD PMID:29581250 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression
multiple interactions
decreases expression		 ISO enzalutamide results in increased expression of KLK3 mRNA
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of KLK3 mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of KLK3 protein; [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of KLK3 protein; enzalutamide promotes the reaction [EPHB4 protein affects the expression of KLK3 protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of KLK3 protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of KLK3 mRNA]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of KLK3 protein]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]
enzalutamide results in decreased expression of KLK3 mRNA; enzalutamide results in decreased expression of KLK3 protein		 CTD PMID:19359544 PMID:23704919 PMID:25970160 PMID:29581250 PMID:30940724 More... NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Krt19 keratin 19 affects expression ISO enzalutamide affects the expression of KRT19 mRNA CTD PMID:30940724 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO enzalutamide results in decreased expression of LCK mRNA CTD PMID:29581250 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions
decreases expression		 ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA] CTD PMID:29581250 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO enzalutamide results in decreased expression of MAF mRNA CTD PMID:29581250 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 affects expression ISO enzalutamide affects the expression of MAML1 mRNA CTD PMID:30940724 NCBI chr10:34,588,639...34,623,024
Ensembl chr10:34,588,646...34,623,338 		JBrowse link
G Maml3 mastermind-like transcriptional coactivator 3 affects expression ISO enzalutamide affects the expression of MAML3 mRNA CTD PMID:30940724 NCBI chr 2:135,720,431...136,137,829
Ensembl chr 2:135,721,021...136,137,814 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [enzalutamide co-treated with GSK-2816126] results in increased expression of MAP1LC3B protein modified form CTD PMID:32805266 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
decreases expression		 ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA] CTD PMID:29581250 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mdk midkine affects expression ISO enzalutamide affects the expression of MDK mRNA CTD PMID:30940724 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 affects expression ISO enzalutamide affects the expression of MIB1 mRNA CTD PMID:30940724 NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689 		JBrowse link
G Mib2 MIB E3 ubiquitin protein ligase 2 affects expression ISO enzalutamide affects the expression of MIB2 mRNA CTD PMID:30940724 NCBI chr 5:166,243,776...166,259,944
Ensembl chr 5:166,243,776...166,259,650 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MKI67 protein] CTD PMID:32184358 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 decreases expression ISO enzalutamide results in decreased expression of MPC2 mRNA CTD PMID:29581250 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Msmb microseminoprotein, beta decreases expression ISO enzalutamide results in decreased expression of MSMB mRNA CTD PMID:33932781 NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
affects expression
multiple interactions
decreases activity		 ISO enzalutamide results in decreased expression of MYC protein
enzalutamide affects the expression of MYC mRNA
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of MYC protein; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MYC protein]
enzalutamide promotes the reaction [lupeol results in decreased activity of MYC protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of MYC protein]		 CTD PMID:24759320 PMID:25970160 PMID:30940724 PMID:32184358 PMID:37777120 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo1b myosin Ib multiple interactions
decreases expression		 ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA] CTD PMID:29581250 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798 		JBrowse link
G Ncstn nicastrin affects expression ISO enzalutamide affects the expression of NCSTN mRNA CTD PMID:30940724 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Neurl1b neuralized E3 ubiquitin protein ligase 1B affects expression ISO enzalutamide affects the expression of NEURL1B mRNA CTD PMID:30940724 NCBI chr10:16,754,002...16,785,049
Ensembl chr10:16,757,208...16,785,119 		JBrowse link
G Nkap NFKB activating protein affects expression ISO enzalutamide affects the expression of NKAP mRNA CTD PMID:30940724 NCBI chr  X:116,373,031...116,392,677
Ensembl chr  X:116,372,839...116,394,945 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression
multiple interactions		 ISO enzalutamide results in decreased expression of NKX3-1 mRNA
enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of NKX3-1 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of NKX3-1 mRNA]		 CTD PMID:29581250 PMID:32184358 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nle1 notchless homolog 1 affects expression ISO enzalutamide affects the expression of NLE1 mRNA CTD PMID:30940724 NCBI chr10:67,834,059...67,844,771
Ensembl chr10:67,834,062...67,842,658 		JBrowse link
G Notch1 notch receptor 1 affects response to substance
multiple interactions
affects expression		 ISO NOTCH1 protein affects the susceptibility to enzalutamide
[NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein
enzalutamide affects the expression of NOTCH1 mRNA		 CTD PMID:30940724 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch2 notch receptor 2 affects expression ISO enzalutamide affects the expression of NOTCH2 mRNA CTD PMID:30940724 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Notch3 notch receptor 3 affects expression ISO enzalutamide affects the expression of NOTCH3 mRNA CTD PMID:30940724 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases cleavage
multiple interactions		 ISO enzalutamide results in decreased cleavage of PARP1 protein
[enzalutamide co-treated with GSK-2816126] results in increased cleavage of PARP1 protein; [nirogacestat results in increased susceptibility to enzalutamide] which results in increased cleavage of PARP1 protein; [NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of PARP1 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]		 CTD PMID:30940724 PMID:32184358 PMID:32805266 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 affects expression ISO enzalutamide affects the expression of PERP mRNA CTD PMID:30940724 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO enzalutamide results in decreased expression of PLA2G5 mRNA CTD PMID:29581250 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of PLK1 mRNA] CTD PMID:32184358 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO enzalutamide results in decreased expression of PLOD2 mRNA CTD PMID:29581250 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 affects expression ISO enzalutamide affects the expression of POFUT1 mRNA CTD PMID:30940724 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
G Psen1 presenilin 1 affects expression ISO enzalutamide affects the expression of PSEN1 mRNA CTD PMID:30940724 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 affects expression ISO enzalutamide affects the expression of PSEN2 mRNA CTD PMID:30940724 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit affects expression ISO enzalutamide affects the expression of PSENEN mRNA CTD PMID:30940724 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO enzalutamide results in decreased expression of PTGER4 mRNA CTD PMID:29581250 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Rbm15 RNA binding motif protein 15 affects expression ISO enzalutamide affects the expression of RBM15 mRNA CTD PMID:30940724 NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region affects expression ISO enzalutamide affects the expression of RBPJ mRNA CTD PMID:30940724 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO enzalutamide results in decreased expression of RGS2 mRNA CTD PMID:29581250 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rhou ras homolog family member U decreases expression ISO enzalutamide results in decreased expression of RHOU mRNA CTD PMID:29581250 NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552 		JBrowse link
G Rps19 ribosomal protein S19 affects expression ISO enzalutamide affects the expression of RPS19 mRNA CTD PMID:30940724 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508 		JBrowse link
G Rps27a ribosomal protein S27a affects expression ISO enzalutamide affects the expression of RPS27A mRNA CTD PMID:30940724 NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 affects expression ISO enzalutamide affects the expression of S1PR3 mRNA CTD PMID:30940724 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase affects expression ISO enzalutamide affects the expression of SEL1L mRNA CTD PMID:30940724 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648 		JBrowse link
G Selenop selenoprotein P decreases expression ISO enzalutamide results in decreased expression of SELENOP mRNA CTD PMID:29581250 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases expression		 ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA] CTD PMID:29581250 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Snw1 SNW domain containing 1 affects expression ISO enzalutamide affects the expression of SNW1 mRNA CTD PMID:30940724 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO enzalutamide results in decreased expression of SOCS2 mRNA CTD PMID:29581250 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects expression ISO enzalutamide affects the expression of SOX9 mRNA CTD PMID:30940724 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Spen spen family transcriptional repressor affects expression ISO enzalutamide affects the expression of SPEN mRNA CTD PMID:30940724 NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811 		JBrowse link
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 decreases expression ISO enzalutamide results in decreased expression of SPOCK1 mRNA CTD PMID:29581250 NCBI chr17:6,741,504...7,221,685
Ensembl chr17:6,742,273...7,224,935 		JBrowse link
G St6galnac1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 decreases expression ISO enzalutamide results in decreased expression of ST6GALNAC1 mRNA CTD PMID:29581250 NCBI chr10:101,972,656...101,983,053
Ensembl chr10:101,972,668...101,983,053 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases response to substance		 ISO enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide] CTD PMID:25970160 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Susd5 sushi domain containing 5 affects expression ISO enzalutamide affects the expression of SUSD5 mRNA CTD PMID:30940724 NCBI chr 8:113,996,771...114,036,133
Ensembl chr 8:113,997,362...114,035,861 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions
decreases expression		 ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of SUZ12 protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of SUZ12 protein] CTD PMID:32805266 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738 		JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO enzalutamide results in decreased expression of TENM1 mRNA CTD PMID:29581250 NCBI chr  X:121,400,466...122,289,877
Ensembl chr  X:121,403,649...122,290,207 		JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 decreases expression
multiple interactions		 ISO enzalutamide results in decreased expression of TMCC3 mRNA
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA]		 CTD PMID:29581250 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926 		JBrowse link
G Tpd52 tumor protein D52 decreases expression ISO enzalutamide results in decreased expression of TPD52 mRNA CTD PMID:29581250 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 decreases expression ISO enzalutamide results in decreased expression of TRPM8 mRNA CTD PMID:29581250 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO enzalutamide affects the expression of UBA52 mRNA CTD PMID:30940724 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807 		JBrowse link
G Ubb ubiquitin B affects expression ISO enzalutamide affects the expression of UBB mRNA CTD PMID:30940724 NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333 		JBrowse link
G Ubc ubiquitin C affects expression ISO enzalutamide affects the expression of UBC mRNA CTD PMID:30940724 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of UBE2C mRNA CTD PMID:32184358 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Wdr12 WD repeat domain 12 affects expression ISO enzalutamide affects the expression of WDR12 mRNA CTD PMID:30940724 NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO enzalutamide results in decreased expression of WWTR1 mRNA CTD PMID:29581250 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      group 19849
        pseudohalo group 4588
          cyano group 4588
            nitrile 4588
              enzalutamide 129
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              monocarboxylic acid amide 15741
                                                arenecarboxamide 8257
                                                  benzamides 8257
                                                    enzalutamide 129
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