Iqgap2 (IQ motif containing GTPase activating protein 2) - Rat Genome Database

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Gene: Iqgap2 (IQ motif containing GTPase activating protein 2) Rattus norvegicus
Analyze
Symbol: Iqgap2
Name: IQ motif containing GTPase activating protein 2
RGD ID: 2321734
Description: Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and thrombin-activated receptor signaling pathway. Predicted to be located in several cellular components, including filopodium; lamellipodium; and microvillus. Predicted to be active in cell cortex. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100360623; ras GTPase-activating-like protein IQGAP2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,629,558 - 28,904,649 (-)NCBIGRCr8
mRatBN7.2226,894,836 - 27,170,270 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,894,825 - 27,170,279 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0226,161,628 - 26,439,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,167,199 - 26,438,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,295,534 - 45,569,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,039,689 - 26,147,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera222,958,327 - 23,102,329 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenol red  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
Tungsten carbide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12515716   PMID:18504258   PMID:18604197   PMID:19056867   PMID:21299499   PMID:21525035   PMID:22493426   PMID:23376485  


Genomics

Comparative Map Data
Iqgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,629,558 - 28,904,649 (-)NCBIGRCr8
mRatBN7.2226,894,836 - 27,170,270 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,894,825 - 27,170,279 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0226,161,628 - 26,439,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,167,199 - 26,438,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,295,534 - 45,569,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,039,689 - 26,147,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera222,958,327 - 23,102,329 (-)NCBICelera
Cytogenetic Map2q12NCBI
IQGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,403,285 - 76,708,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,403,285 - 76,708,132 (+)EnsemblGRCh38hg38GRCh38
GRCh37575,699,110 - 76,003,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36575,734,905 - 76,039,713 (+)NCBINCBI36Build 36hg18NCBI36
Build 34575,734,904 - 76,039,711NCBI
Celera571,592,826 - 71,897,903 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef570,906,692 - 71,211,466 (+)NCBIHuRef
CHM1_1575,131,847 - 75,437,149 (+)NCBICHM1_1
T2T-CHM13v2.0576,885,042 - 77,189,993 (+)NCBIT2T-CHM13v2.0
Iqgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,763,685 - 96,028,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,763,682 - 96,028,991 (-)EnsemblGRCm39 Ensembl
GRCm381395,627,177 - 95,892,280 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,627,174 - 95,892,483 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,397,132 - 96,661,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,397,132 - 96,661,877 (-)NCBIMGSCv36mm8
Celera1399,243,963 - 99,510,431 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.26NCBI
Iqgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542524,167,104 - 24,385,146 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542524,167,985 - 24,384,912 (-)NCBIChiLan1.0ChiLan1.0
IQGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,597,137 - 38,902,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,750,767 - 37,056,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,593,574 - 38,900,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1539,137,539 - 39,516,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,138,359 - 39,516,596 (-)Ensemblpanpan1.1panPan2
IQGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,894,192 - 30,134,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,894,870 - 30,174,259 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,132,907 - 31,420,147 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,818,056 - 30,105,892 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,818,467 - 30,106,093 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,749,579 - 30,036,702 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,730,444 - 30,016,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,099,810 - 30,387,253 (-)NCBIUU_Cfam_GSD_1.0
Iqgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,317,091 - 190,603,571 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549255,303 - 541,917 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549256,097 - 541,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,294,530 - 85,633,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,294,423 - 85,633,645 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2286,916,946 - 87,086,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IQGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,672,171 - 70,979,766 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,672,553 - 70,979,763 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,502,207 - 19,811,126 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqgap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624869889,091 - 1,171,983 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624869888,868 - 1,172,747 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iqgap2
2066 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:23
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000035017
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat

Markers in Region
D2Rat73  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,999,571 - 26,999,741 (+)MAPPERmRatBN7.2
Rnor_6.0226,267,995 - 26,268,162NCBIRnor6.0
Rnor_5.0245,399,390 - 45,399,557UniSTSRnor5.0
RGSC_v3.4226,101,089 - 26,101,256UniSTSRGSC3.4
RGSC_v3.4226,101,088 - 26,101,256RGDRGSC3.4
RGSC_v3.1226,021,458 - 26,021,625RGD
Celera223,061,384 - 23,061,537UniSTS
RH 3.4 Map213.3RGD
RH 3.4 Map213.3UniSTS
RH 2.0 Map281.9RGD
FHH x ACI Map214.1699RGD
D2Rat124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,917,817 - 26,918,153 (+)MAPPERmRatBN7.2
mRatBN7.28116,760,064 - 116,760,124 (-)MAPPERmRatBN7.2
mRatBN7.2226,917,948 - 26,918,153 (+)MAPPERmRatBN7.2
Rnor_6.0226,186,318 - 26,186,520NCBIRnor6.0
Rnor_6.0226,186,097 - 26,186,520NCBIRnor6.0
Rnor_5.0245,317,834 - 45,318,036UniSTSRnor5.0
Rnor_5.0245,317,613 - 45,318,036UniSTSRnor5.0
Celera222,980,838 - 22,981,040UniSTS
RH 3.4 Map213.3RGD
RH 3.4 Map213.3UniSTS
RH 2.0 Map278.1RGD
SHRSP x BN Map27.2098RGD
FHH x ACI Map212.9999RGD
RH131126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,977,529 - 26,977,729 (+)MAPPERmRatBN7.2
Rnor_6.0226,245,965 - 26,246,164NCBIRnor6.0
Rnor_5.0245,377,360 - 45,377,559UniSTSRnor5.0
RGSC_v3.4226,079,050 - 26,079,249UniSTSRGSC3.4
Celera223,039,410 - 23,039,609UniSTS
RH 3.4 Map213.3UniSTS
RH136887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,572,462 - 55,572,661 (+)MAPPERmRatBN7.2
mRatBN7.2226,894,929 - 26,895,128 (+)MAPPERmRatBN7.2
Rnor_6.01857,443,806 - 57,444,004NCBIRnor6.0
Rnor_6.0226,161,722 - 26,161,920NCBIRnor6.0
Rnor_5.01856,670,004 - 56,670,202UniSTSRnor5.0
Rnor_5.0245,295,628 - 45,295,826UniSTSRnor5.0
RGSC_v3.41858,104,962 - 58,105,160UniSTSRGSC3.4
Celera1853,719,920 - 53,720,118UniSTS
Celera222,958,421 - 22,958,619UniSTS
RH138303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2227,086,080 - 27,086,255 (+)MAPPERmRatBN7.2
Rnor_6.0226,354,528 - 26,354,702NCBIRnor6.0
Rnor_5.0245,485,581 - 45,485,755UniSTSRnor5.0
RGSC_v3.4226,187,047 - 26,187,221UniSTSRGSC3.4
Celera223,147,197 - 23,147,371UniSTS
RH 3.4 Map213.3UniSTS
AI014006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,905,548 - 26,905,708 (+)MAPPERmRatBN7.2
Rnor_6.0226,172,398 - 26,172,557NCBIRnor6.0
Rnor_5.0245,306,304 - 45,306,463UniSTSRnor5.0
Celera222,969,037 - 22,969,196UniSTS
RH 3.4 Map213.3UniSTS
F2rl2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,975,969 - 26,976,089 (+)MAPPERmRatBN7.2
Rnor_6.0226,244,405 - 26,244,524NCBIRnor6.0
Rnor_5.0245,375,800 - 45,375,919UniSTSRnor5.0
Celera223,037,850 - 23,037,969UniSTS
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 56 41 11 41 31 35 31 9
Low 1 43 1 8 8 9 43 10 2 8
Below cutoff 2

Sequence


RefSeq Acc Id: ENSRNOT00000035017   ⟹   ENSRNOP00000029373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,903,297 - 27,118,445 (-)Ensembl
Rnor_6.0 Ensembl226,167,199 - 26,438,790 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107205   ⟹   ENSRNOP00000089989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,894,825 - 27,170,279 (-)Ensembl
RefSeq Acc Id: NM_001427125   ⟹   NP_001414054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,629,558 - 28,904,649 (-)NCBI
RefSeq Acc Id: XM_008760685   ⟹   XP_008758907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,629,558 - 28,723,785 (-)NCBI
mRatBN7.2226,895,560 - 26,989,107 (-)NCBI
Rnor_6.0226,161,628 - 26,257,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103457   ⟹   XP_038959385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,629,558 - 28,723,779 (-)NCBI
mRatBN7.2226,895,560 - 26,989,063 (-)NCBI
RefSeq Acc Id: XM_039103458   ⟹   XP_038959386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,629,558 - 28,723,523 (-)NCBI
mRatBN7.2226,895,560 - 26,988,912 (-)NCBI
RefSeq Acc Id: XM_063281081   ⟹   XP_063137151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,629,558 - 28,775,325 (-)NCBI
RefSeq Acc Id: XP_008758907   ⟸   XM_008760685
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000029373   ⟸   ENSRNOT00000035017
RefSeq Acc Id: XP_038959385   ⟸   XM_039103457
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038959386   ⟸   XM_039103458
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000089989   ⟸   ENSRNOT00000107205
RefSeq Acc Id: NP_001414054   ⟸   NM_001427125
- UniProtKB: A0A8I6AM38 (UniProtKB/TrEMBL),   F1LW74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137151   ⟸   XM_063281081
- Peptide Label: isoform X1
Protein Domains
Calponin-homology (CH)   Ras-GAP   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LW74-F1-model_v2 AlphaFold F1LW74 1-1425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691082
Promoter ID:EPDNEW_R1604
Type:initiation region
Name:Iqgap2_1
Description:IQ motif containing GTPase activating protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0226,438,750 - 26,438,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321734 AgrOrtholog
BioCyc Gene G2FUF-54802 BioCyc
Ensembl Genes ENSRNOG00000025406 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035017.7 UniProtKB/TrEMBL
  ENSRNOT00000107205.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
NCBI Gene 100360623 ENTREZGENE
PANTHER RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2 UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
PhenoGen Iqgap2 PhenoGen
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025406 RatGTEx
SMART RasGAP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  RGC domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
UniProt A0A8I6AM38 ENTREZGENE, UniProtKB/TrEMBL
  F1LW74 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Iqgap2  IQ motif containing GTPase activating protein 2  LOC100360623  IQ motif containing GTPase activating protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360623  IQ motif containing GTPase activating protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL