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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:reserpine
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Accession:CHEBI:28487 term browser browse the term
Definition:An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Synonyms:exact_synonym: methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
 related_synonym: (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;   3,4,5-trimethoxybenzoyl methyl reserpate;   Apoplon;   Formula=C33H40N2O9;   InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1;   InChIKey=QEVHRUUCFGRFIF-MDEJGZGSSA-N;   Reserpin;   SMILES=[H][C@]12C[C@@H](OC(=O)c3cc(OC)c(OC)c(OC)c3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCc3c1[nH]c1cc(OC)ccc31)C2;   Serpalan
 alt_id: CHEBI:26531;   CHEBI:8808
 xref: Beilstein:102014;   Beilstein:5326088;   CAS:50-55-5;   DrugBank:DB00206;   Drug_Central:2370;   HMDB:HMDB0014351;   KEGG:C06539;   KEGG:D00197;   KNApSAcK:C00001763;   LINCS:LSM-4162
 xref_mesh: MESH:D012110
 xref: PMID:20701244;   PMID:20825390;   PMID:24603678;   Reaxys:102014;   Wikipedia:Reserpine


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reserpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity		 ISO Reserpine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Reserpine results in decreased activity of ABCB11 protein		 CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases expression
decreases activity		 ISO
EXP		 Cycloheximide promotes the reaction [Reserpine results in increased expression of ABCB1 mRNA]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Reserpine results in increased expression of ABCB1 mRNA; Reserpine results in increased expression of ABCB1 protein
Reserpine results in decreased activity of ABCB1 protein
Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]		 CTD PMID:7476894 PMID:8632764 PMID:10617675 PMID:12235267 PMID:19528478 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of irinotecan] CTD PMID:12869632 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Ache acetylcholinesterase multiple interactions
affects activity		 ISO [Plant Extracts results in increased abundance of Dronabinol] inhibits the reaction [Reserpine affects the activity of ACHE protein] CTD PMID:28212939 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Adra1d adrenergic receptor, alpha 1d increases response to substance
increases expression		 ISO ADRA1D protein results in increased susceptibility to Reserpine
Reserpine results in increased expression of ADRA1D mRNA		 CTD PMID:15159276 PMID:17676312 NCBI chr 2:131,387,277...131,404,417
Ensembl chr 2:131,387,770...131,404,203 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a increases expression ISO Reserpine results in increased expression of ADRA2A mRNA CTD PMID:11264240 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Adrb1 adrenergic receptor, beta 1 increases expression
increases stability		 ISO Reserpine results in increased expression of ADRB1 mRNA; Reserpine results in increased expression of ADRB1 protein
Reserpine results in increased stability of ADRB1 mRNA		 CTD PMID:1336118 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases expression ISO Reserpine results in increased expression of ADRB2 mRNA CTD PMID:1664493 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression ISO Reserpine results in increased expression of AGTR2 mRNA; Reserpine results in increased expression of AGTR2 protein CTD PMID:20964730 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO Reserpine results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions		 EXP Reserpine results in decreased phosphorylation of AKT1 protein
arsenic trioxide promotes the reaction [Reserpine results in decreased phosphorylation of AKT1 protein]		 CTD PMID:26114099 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Amd1 S-adenosylmethionine decarboxylase 1 multiple interactions EXP Reserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein] CTD PMID:17371283 NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184 		JBrowse link
G Ar androgen receptor multiple interactions ISO Reserpine inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arc activity regulated cytoskeletal-associated protein multiple interactions ISO Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA] CTD PMID:7722525 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 ISO IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein] CTD PMID:19463876 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein] CTD PMID:19463876 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression
multiple interactions		 EXP
ISO		 Reserpine results in decreased expression of BDNF protein
arsenic trioxide promotes the reaction [Reserpine results in decreased expression of BDNF protein]
cerebrolysin inhibits the reaction [Reserpine results in decreased expression of BDNF protein]; Fluoxetine inhibits the reaction [Reserpine results in decreased expression of BDNF protein]		 CTD PMID:26114099 PMID:33279466 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Reserpine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G C3 complement component 3 affects expression ISO Reserpine affects the expression of C3 mRNA CTD PMID:18363858 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein] CTD PMID:19463876 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein] CTD PMID:19463876 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase multiple interactions
increases expression
decreases expression		 ISO Plant Extracts inhibits the reaction [Reserpine results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Reserpine results in decreased expression of CAT protein]
Reserpine results in increased expression of CAT protein		 CTD PMID:14685008 PMID:16444668 PMID:19109989 PMID:19761039 PMID:20628966 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Reserpine results in decreased expression of CCND1 mRNA; Reserpine results in decreased expression of CCND1 protein CTD PMID:19607803 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression		 EXP
ISO		 CHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]
Reserpine results in increased expression of CHGA mRNA		 CTD PMID:1907749 PMID:8189248 PMID:12799369 NCBI chr12:102,521,200...102,531,286
Ensembl chr12:102,521,228...102,531,287 		JBrowse link
G Chgb chromogranin B increases expression ISO Reserpine results in increased expression of CHGB mRNA; Reserpine results in increased expression of CHGB protein CTD PMID:1907749 PMID:8189248 PMID:8361347 NCBI chr 2:132,623,562...132,636,999
Ensembl chr 2:132,623,198...132,636,999 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS increases expression
decreases expression		 ISO Reserpine results in increased expression of CHRM1 mRNA
Reserpine results in decreased expression of CHRM1 protein		 CTD PMID:1506860 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951 		JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression ISO Reserpine results in decreased expression of CNR1 mRNA CTD PMID:11358453 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cpe carboxypeptidase E increases expression ISO Reserpine results in increased expression of CPE mRNA CTD PMID:8189248 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088 		JBrowse link
G Crem cAMP responsive element modulator multiple interactions
increases expression		 ISO Reserpine promotes the reaction [CREM protein binds to TH promoter]
Reserpine results in increased expression of CREM mRNA alternative form; Reserpine results in increased expression of CREM protein; Reserpine results in increased expression of CREM protein alternative form		 CTD PMID:8810303 PMID:11438978 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Reserpine results in increased expression of CRH mRNA; Reserpine results in increased expression of CRH protein CTD PMID:1850078 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Reserpine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15627480 PMID:18493746 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:16510159 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases expression ISO Reserpine results in increased expression of CYP3A5 protein CTD PMID:8632764 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dbh dopamine beta hydroxylase decreases activity
increases activity
increases stability
increases expression		 ISO Reserpine results in decreased activity of DBH protein
Reserpine results in increased activity of DBH protein
Reserpine results in increased stability of DBH protein
Reserpine results in increased expression of DBH mRNA		 CTD PMID:1359376 PMID:2325165 PMID:7984052 PMID:8189248 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212 		JBrowse link
G Ddc dopa decarboxylase increases expression ISO Reserpine results in increased expression of DDC mRNA CTD PMID:1359376 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Reserpine results in increased expression of DRD1 mRNA CTD PMID:8419537 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases expression		 EXP
ISO		 DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
Reserpine results in increased expression of DRD2 mRNA; Reserpine results in increased expression of DRD2 mRNA alternative form		 CTD PMID:1331675 PMID:8419537 PMID:11172060 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 ISO [Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA; eticlopride inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA]; Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]]
Reserpine results in increased expression of EGR1 mRNA; Reserpine results in increased expression of EGR1 protein		 CTD PMID:1347779 PMID:8063705 PMID:9729266 PMID:9890435 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases response to substance ISO ERBB2 protein results in increased susceptibility to Reserpine CTD PMID:8093862 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Fabp7 fatty acid binding protein 7, brain affects expression ISO Reserpine affects the expression of FABP7 mRNA CTD PMID:18363858 NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases phosphorylation
increases expression		 ISO 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine promotes the reaction [Reserpine results in increased expression of FOS protein]; 3,7-dimethyl-1-propargylxanthine inhibits the reaction [Reserpine results in increased expression of FOS protein]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; Reserpine promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein]; Reserpine promotes the reaction [Amphetamine results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]
Reserpine results in increased phosphorylation of FOS protein
Reserpine results in increased expression of FOS mRNA; Reserpine results in increased expression of FOS protein		 CTD PMID:1359376 PMID:1686849 PMID:2118661 PMID:7845612 PMID:7914358 More... NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions		 ISO Reserpine results in increased expression of GAD1 mRNA
Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]		 CTD PMID:8774452 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression
multiple interactions
increases expression		 ISO Reserpine results in decreased expression of GAL mRNA
Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA]		 CTD PMID:1279347 PMID:1698642 PMID:1705056 PMID:1717808 PMID:9512271 More... NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544 		JBrowse link
G Gast gastrin multiple interactions ISO Reserpine inhibits the reaction [Levodopa results in decreased cleavage of GAST protein] CTD PMID:10332097 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822 		JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Reserpine results in increased expression of GCH1 mRNA; Reserpine results in increased expression of GCH1 mRNA alternative form CTD PMID:8103077 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO Reserpine results in increased expression of GCNT3 mRNA CTD PMID:26198647 NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370 		JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression ISO Reserpine results in increased expression of GNAI1 protein CTD PMID:11264240 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353 		JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression ISO Reserpine results in increased expression of GNAI2 mRNA; Reserpine results in increased expression of GNAI2 protein CTD PMID:8419537 PMID:11264240 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression ISO Reserpine results in increased expression of GNAI3 protein CTD PMID:11264240 NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462 		JBrowse link
G Gnao1 guanine nucleotide binding protein, alpha O increases expression ISO Reserpine results in increased expression of GNAO1 mRNA; Reserpine results in increased expression of GNAO1 protein CTD PMID:8419537 PMID:11264240 NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016 		JBrowse link
G Gnas GNAS complex locus increases expression
decreases expression		 ISO Reserpine results in increased expression of GNAS mRNA; Reserpine results in increased expression of GNAS protein
Reserpine results in decreased expression of GNAS protein alternative form		 CTD PMID:1336118 PMID:8419537 PMID:11264240 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Grm5 glutamate receptor, metabotropic 5 decreases expression
increases expression		 ISO Reserpine results in decreased expression of GRM5 mRNA
Reserpine results in increased expression of GRM5 protein		 CTD PMID:16890937 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Reserpine results in increased expression of HGF protein CTD PMID:16081063 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hspg2 perlecan (heparan sulfate proteoglycan 2) multiple interactions EXP HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine] CTD PMID:20072119 NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A decreases expression EXP Reserpine results in decreased expression of HTR1A protein CTD PMID:26114099 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Iapp islet amyloid polypeptide multiple interactions ISO IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 6:142,244,151...142,249,546
Ensembl chr 6:142,244,149...142,249,687 		JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions		 ISO Reserpine results in decreased expression of IL10 mRNA; Reserpine results in decreased expression of IL10 protein
SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA]; SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein]		 CTD PMID:16985181 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il18 interleukin 18 increases expression ISO Reserpine results in increased expression of IL18 mRNA CTD PMID:8999896 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Jun jun proto-oncogene increases expression ISO Reserpine results in increased expression of JUN mRNA CTD PMID:1359376 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Junb jun B proto-oncogene multiple interactions ISO Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]] CTD PMID:1347779 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 decreases activity
multiple interactions		 ISO Reserpine results in decreased activity of KCNA3 protein
[Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 3:106,943,486...106,947,223
Ensembl chr 3:106,943,485...106,945,386 		JBrowse link
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 increases expression ISO Reserpine results in increased expression of KCNA5 mRNA CTD PMID:12606256 NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375 		JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 decreases expression ISO Reserpine results in decreased expression of KCND2 mRNA CTD PMID:12606256 NCBI chr 6:21,212,101...21,729,804
Ensembl chr 6:21,215,502...21,729,804 		JBrowse link
G Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 decreases expression ISO Reserpine results in decreased expression of KCND3 mRNA CTD PMID:12606256 NCBI chr 3:105,359,206...105,581,318
Ensembl chr 3:105,359,646...105,581,318 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions		 ISO Reserpine results in decreased activity of KCNH2 protein
[Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium		 CTD PMID:21362439 PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Lep leptin increases expression EXP Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Myc myelocytomatosis oncogene increases response to substance
decreases expression		 EXP
ISO		 MYC protein results in increased susceptibility to Reserpine
Reserpine results in decreased expression of MYC protein		 CTD PMID:8093862 PMID:19607803 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Reserpine results in increased expression of NCF1 mRNA; Reserpine results in increased expression of NCF1 protein CTD PMID:20964730 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases activity EXP Reserpine results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ngf nerve growth factor increases expression ISO Reserpine results in increased expression of NGF mRNA; Reserpine results in increased expression of NGF protein CTD PMID:1996081 PMID:8593794 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases expression ISO Reserpine results in increased expression of NOS1 mRNA; Reserpine results in increased expression of NOS1 protein CTD PMID:7533141 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Npy neuropeptide Y multiple interactions
decreases expression
increases expression		 ISO Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]; Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]
Reserpine results in decreased expression of NPY mRNA; Reserpine results in decreased expression of NPY protein
Reserpine results in increased expression of NPY mRNA; Reserpine results in increased expression of NPY protein		 CTD PMID:1671012 PMID:1676830 PMID:1687976 PMID:1698642 PMID:1713314 More... NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity		 ISO
EXP		 [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
Reserpine results in decreased activity of NR1I3 protein		 CTD PMID:17041008 PMID:30203046 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Reserpine results in increased expression of NR3C1 mRNA CTD PMID:7984052 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions
decreases expression		 EXP arsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Nts neurotensin increases expression ISO Reserpine results in increased expression of NTS mRNA CTD PMID:1850078 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression
multiple interactions		 ISO
EXP		 Reserpine results in decreased expression of ODC1 protein
Reserpine inhibits the reaction [CB 3717 results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [CB 3717 results in increased expression of ODC1 mRNA]; Reserpine inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA]		 CTD PMID:6519379 PMID:9194572 PMID:10354516 PMID:17371283 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase increases expression ISO Reserpine results in increased expression of PAM mRNA CTD PMID:8189248 NCBI chr 1:97,748,816...98,023,578
Ensembl chr 1:97,722,839...98,023,371 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Reserpine results in increased expression of PCSK2 mRNA CTD PMID:8189248 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Penk preproenkephalin multiple interactions
decreases expression
increases expression		 ISO Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA]
Reserpine results in decreased expression of PENK mRNA
Reserpine results in increased expression of PENK mRNA; Reserpine results in increased expression of PENK protein		 CTD PMID:1331675 PMID:1850078 PMID:3188958 PMID:3838946 PMID:4078631 More... NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase multiple interactions
decreases expression
increases expression		 ISO Chlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Dexamethasone inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Reserpine results in increased expression of and results in increased activity of PNMT protein
Reserpine results in increased expression of PNMT mRNA		 CTD PMID:1359376 PMID:1687976 PMID:1714554 PMID:2903502 PMID:8063705 More... NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007 		JBrowse link
G Pomc pro-opiomelanocortin-alpha increases expression
multiple interactions		 ISO Reserpine results in increased expression of POMC mRNA; Reserpine results in increased expression of POMC protein alternative form
POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]		 CTD PMID:8479280 PMID:20504635 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha decreases expression EXP Reserpine results in decreased expression of PRKACA protein CTD PMID:26114099 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Prl prolactin increases expression ISO Reserpine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Reserpine results in increased expression of PTGS2 protein CTD PMID:16081063 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase increases expression ISO Reserpine results in increased expression of PTS mRNA CTD PMID:7545485 NCBI chr 9:50,432,917...50,440,017
Ensembl chr 9:50,432,917...50,440,024 		JBrowse link
G Rasd2 RASD family, member 2 decreases expression ISO Reserpine results in decreased expression of RASD2 mRNA CTD PMID:16352400 NCBI chr 8:75,940,572...75,950,741
Ensembl chr 8:75,940,572...75,950,741 		JBrowse link
G Rgs10 regulator of G-protein signalling 10 decreases expression ISO Reserpine results in decreased expression of RGS10 mRNA CTD PMID:14505795 NCBI chr 7:127,975,345...128,020,993
Ensembl chr 7:127,975,345...128,020,482 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Reserpine results in decreased expression of RGS2 mRNA CTD PMID:14505795 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Reserpine results in decreased expression of RGS4 mRNA CTD PMID:14505795 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression ISO Reserpine results in decreased expression of RGS5 mRNA CTD PMID:14505795 NCBI chr 1:169,483,070...169,523,367
Ensembl chr 1:169,483,070...169,523,382 		JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression ISO Reserpine results in decreased expression of RGS8 mRNA CTD PMID:14505795 NCBI chr 1:153,528,612...153,573,415
Ensembl chr 1:153,528,771...153,576,069 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance
decreases expression		 EXP
ISO		 RGS9 affects the susceptibility to Reserpine
Reserpine results in decreased expression of RGS9 mRNA		 CTD PMID:14505795 PMID:15728856 NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955 		JBrowse link
G Scg2 secretogranin II increases expression ISO Reserpine results in increased expression of SCG2 mRNA CTD PMID:1907749 PMID:8189248 PMID:8361347 NCBI chr 1:79,412,083...79,417,743
Ensembl chr 1:79,412,386...79,417,837 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Siah1a siah E3 ubiquitin protein ligase 1A increases expression ISO Reserpine results in increased expression of SIAH1 mRNA CTD PMID:19607803 NCBI chr 8:87,442,450...87,472,634
Ensembl chr 8:87,450,635...87,472,562 		JBrowse link
G Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 decreases activity
multiple interactions		 EXP
ISO		 Reserpine results in decreased activity of SLC18A1 protein
Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]		 CTD PMID:8245983 PMID:21712771 NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 affects binding
decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases expression		 ISO
EXP		 Reserpine binds to SLC18A2 protein
SLC18A2 gene SNP results in decreased susceptibility to Reserpine
Reserpine results in decreased activity of SLC18A2 protein
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]
SLC18A2 affects the susceptibility to Reserpine
Reserpine results in increased expression of SLC18A2 mRNA
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]		 CTD PMID:1438304 PMID:7912402 PMID:8189248 PMID:9038139 PMID:15475732 More... NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 decreases expression ISO Reserpine results in decreased expression of SLC6A2 mRNA CTD PMID:7478180 PMID:7616203 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 decreases activity
affects response to substance		 EXP Reserpine results in decreased activity of SLC6A3 protein
SLC6A3 gene mutant form affects the susceptibility to Reserpine		 CTD PMID:17664021 PMID:19615345 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 decreases expression ISO Reserpine results in decreased expression of SLC6A4 mRNA CTD PMID:10027743 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Snca synuclein, alpha affects response to substance EXP SNCA protein mutant form affects the susceptibility to Reserpine CTD PMID:18622040 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Reserpine results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Syt7 synaptotagmin VII multiple interactions ISO [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr19:10,366,142...10,430,545
Ensembl chr19:10,366,454...10,430,544 		JBrowse link
G Tac1 tachykinin 1 multiple interactions
increases expression		 ISO [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine] results in increased expression of TAC1 mRNA; Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:9751140 PMID:17719177 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Reserpine results in increased expression of TFF1 mRNA CTD PMID:35307500 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
increases stability
affects activity
decreases expression
increases activity		 EXP
ISO		 Reserpine results in increased expression of TH mRNA
Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]; Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Reserpine promotes the reaction [CREM protein binds to TH promoter]; Reserpine results in increased expression of and results in increased activity of TH protein
Reserpine results in increased stability of TH mRNA
Reserpine results in decreased expression of TH mRNA
Reserpine results in increased expression of TH mRNA; Reserpine results in increased expression of TH protein
Reserpine results in increased activity of TH protein		 CTD PMID:1350653 PMID:1359376 PMID:1676830 PMID:1687822 PMID:1687976 More... NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Reserpine results in increased expression of TNF protein
cerebrolysin inhibits the reaction [Reserpine results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [Reserpine results in increased expression of TNF protein]		 CTD PMID:33279466 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions
increases expression		 ISO IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Tph1 tryptophan hydroxylase 1 increases activity
decreases activity		 ISO Reserpine results in increased activity of TPH1 protein
Reserpine results in decreased activity of TPH1 protein		 CTD PMID:8369965 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Try10 trypsin 10 decreases expression
increases expression		 ISO Reserpine results in decreased expression of PRSS1 protein
Reserpine results in increased expression of PRSS1 protein		 CTD PMID:8625754 NCBI chr 6:41,331,039...41,334,878
Ensembl chr 6:41,331,039...41,334,848 		JBrowse link
G Vgf VGF nerve growth factor inducible increases expression ISO Reserpine results in increased expression of VGF mRNA CTD PMID:8189248 NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205 		JBrowse link
G Vip vasoactive intestinal polypeptide increases expression ISO Reserpine results in increased expression of VIP mRNA CTD PMID:1850078 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        xenobiotic 19678
          reserpine 118
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            heteroorganic entity 21490
                              organonitrogen compound 19814
                                alkaloid 7893
                                  indole alkaloid 1949
                                    terpenoid indole alkaloid 1507
                                      monoterpenoid indole alkaloid 1489
                                        yohimban alkaloid 157
                                          reserpic acid 118
                                            reserpine 118
paths to the root