Pnmt (phenylethanolamine-N-methyltransferase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Pnmt (phenylethanolamine-N-methyltransferase) Mus musculus
Analyze
Symbol: Pnmt
Name: phenylethanolamine-N-methyltransferase
RGD ID: 11126
MGI Page MGI
Description: Predicted to enable phenylethanolamine N-methyltransferase activity. Predicted to be involved in epinephrine biosynthetic process and norepinephrine metabolic process. Predicted to act upstream of or within catecholamine biosynthetic process and methylation. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; gonad; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; crocidolite asbestos.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: noradrenaline N-methyltransferase; Pe; Pent; phenylethanolamine N-methyltransferase; PNMTase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,277,449 - 98,279,006 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,277,276 - 98,279,007 (+)Ensembl
GRCm381198,386,623 - 98,388,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,386,450 - 98,388,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,247,946 - 98,249,411 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,202,722 - 98,204,187 (+)NCBImm8
Celera11108,040,856 - 108,042,321 (+)NCBICelera
Cytogenetic Map11DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1320721   PMID:1348741   PMID:7628695   PMID:7931317   PMID:8000434   PMID:8221886   PMID:10349636   PMID:10357937   PMID:10552930   PMID:11042159   PMID:11076861   PMID:11089558  
PMID:11217851   PMID:11784869   PMID:12096893   PMID:12361965   PMID:12438096   PMID:12438097   PMID:12466851   PMID:12477932   PMID:12591599   PMID:12933902   PMID:14681479   PMID:15517585  
PMID:15824970   PMID:16141072   PMID:16141073   PMID:16176945   PMID:16467531   PMID:16602821   PMID:16691441   PMID:17196587   PMID:17478475   PMID:17698731   PMID:17853069   PMID:18094025  
PMID:19120124   PMID:20118198   PMID:20351116   PMID:20619316   PMID:20875861   PMID:21267068   PMID:21818395   PMID:21873635   PMID:22580128   PMID:22706789   PMID:22962254   PMID:23204390  
PMID:23268986   PMID:23648511   PMID:24194600   PMID:24565998   PMID:25071457   PMID:25093893   PMID:25661788   PMID:25989220   PMID:26909542   PMID:27576662   PMID:27626380   PMID:28228269  
PMID:28700664   PMID:29879378   PMID:30319349   PMID:30850723   PMID:31677273   PMID:33192300   PMID:33500353  


Genomics

Comparative Map Data
Pnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,277,449 - 98,279,006 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,277,276 - 98,279,007 (+)Ensembl
GRCm381198,386,623 - 98,388,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,386,450 - 98,388,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,247,946 - 98,249,411 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,202,722 - 98,204,187 (+)NCBImm8
Celera11108,040,856 - 108,042,321 (+)NCBICelera
Cytogenetic Map11DNCBI
PNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1739,667,981 - 39,670,475 (+)EnsemblGRCh38hg38GRCh38
GRCh381739,668,019 - 39,670,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,824,272 - 37,826,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,078,033 - 35,080,254 (+)NCBINCBI36hg18NCBI36
Build 341735,078,032 - 35,080,254NCBI
Celera1734,484,236 - 34,486,457 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,618,165 - 33,620,658 (+)NCBIHuRef
CHM1_11738,060,055 - 38,062,549 (+)NCBICHM1_1
Pnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,383,019 - 83,386,557 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1083,384,923 - 83,386,556 (+)Ensembl
Rnor_6.01086,340,893 - 86,342,501 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,340,940 - 86,342,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,137,019 - 86,138,436 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1082,132,183 - 82,134,127 (+)NCBICelera
Cytogenetic Map10q31NCBI
Pnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,416,121 - 14,417,901 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,414,836 - 14,417,972 (+)NCBIChiLan1.0ChiLan1.0
PNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,835,277 - 17,837,180 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,835,277 - 17,837,180 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,618,399 - 17,620,691 (-)NCBIMhudiblu_PPA_v0panPan3
PNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,808,505 - 22,810,587 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,808,601 - 22,810,551 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,280,958 - 22,282,522 (-)NCBI
ROS_Cfam_1.0923,602,151 - 23,603,715 (-)NCBI
UMICH_Zoey_3.1922,374,797 - 22,376,361 (-)NCBI
UNSW_CanFamBas_1.0922,635,796 - 22,637,358 (-)NCBI
UU_Cfam_GSD_1.0922,760,897 - 22,762,461 (-)NCBI
Pnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,213,520 - 22,217,186 (-)NCBI
SpeTri2.0NW_00493649014,858,682 - 14,861,614 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,648,397 - 22,650,002 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,648,396 - 22,651,520 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,110,418 - 23,111,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,496,290 - 66,498,840 (-)NCBI
ChlSab1.1 Ensembl1666,496,027 - 66,499,111 (-)Ensembl
Vero_WHO_p1.0NW_02366607737,407,873 - 37,410,511 (-)NCBI
Pnmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247953,408,559 - 3,410,669 (-)NCBI

Position Markers
L12687  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,388,190 - 98,388,342UniSTSGRCm38
MGSCv371198,249,504 - 98,249,656UniSTSGRCm37
Celera11108,042,414 - 108,042,566UniSTS
Cytogenetic Map11DUniSTS
Whitehead_YAC11 UniSTS
AI503981  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,384,769 - 98,384,863UniSTSGRCm38
MGSCv371198,246,083 - 98,246,177UniSTSGRCm37
Celera11108,038,993 - 108,039,087UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111308.14UniSTS
Whitehead/MRC_RH111306.72UniSTS
UniSTS:491268  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,386,602 - 98,388,197UniSTSGRCm38
MGSCv371198,247,916 - 98,249,511UniSTSGRCm37
Celera11108,040,826 - 108,042,421UniSTS
Cytogenetic Map11DUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117768304799486994Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179922933104611872Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1181000000102000000Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187800372103383289Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118880876299190771Mouse
1301313Pas5a_mpulmonary adenoma susceptibility 5a (mouse)Not determined118907597898974942Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119700686799436202Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:381
Interacting mature miRNAs:417
Transcripts:ENSMUST00000041301, ENSMUST00000124527
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041301   ⟹   ENSMUSP00000035549
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,277,276 - 98,279,007 (+)Ensembl
GRCm38.p6 Ensembl1198,386,450 - 98,388,181 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124527
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1198,277,538 - 98,278,308 (+)Ensembl
GRCm38.p6 Ensembl1198,386,712 - 98,387,482 (+)Ensembl
RefSeq Acc Id: NM_008890   ⟹   NP_032916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,277,449 - 98,279,006 (+)NCBI
GRCm381198,386,623 - 98,388,180 (+)NCBI
MGSCv371198,247,946 - 98,249,411 (+)RGD
Celera11108,040,856 - 108,042,321 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032916 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA68934 (Get FASTA)   NCBI Sequence Viewer  
  AAI19080 (Get FASTA)   NCBI Sequence Viewer  
  AAI20790 (Get FASTA)   NCBI Sequence Viewer  
  EDL16137 (Get FASTA)   NCBI Sequence Viewer  
  P40935 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_032916   ⟸   NM_008890
- UniProtKB: P40935 (UniProtKB/Swiss-Prot),   Q0VB50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035549   ⟸   ENSMUST00000041301

Promoters
RGD ID:8676486
Promoter ID:EPDNEW_M16273
Type:multiple initiation site
Name:Pnmt_1
Description:Mus musculus phenylethanolamine-N-methyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,386,626 - 98,386,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97724 AgrOrtholog
Ensembl Genes ENSMUSG00000038216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035549 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041301 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro NNMT/PNMT/TEMT_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NNMT_TEMT_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18948 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97724 ENTREZGENE
NCBI Gene 18948 ENTREZGENE
PANTHER PTHR10867 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PNMT RGD
PhenoGen Pnmt PhenoGen
PIRSF PNMTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_MT_NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P40935 ENTREZGENE, UniProtKB/Swiss-Prot
  Q0VB50 ENTREZGENE, UniProtKB/TrEMBL