Amd1 (S-adenosylmethionine decarboxylase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Amd1 (S-adenosylmethionine decarboxylase 1) Mus musculus
Analyze
Symbol: Amd1
Name: S-adenosylmethionine decarboxylase 1
RGD ID: 10151
MGI Page MGI
Description: Enables adenosylmethionine decarboxylase activity. Acts upstream of or within in utero embryonic development; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1); PARTICIPATES IN biogenic amines and polyamines metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1; AdoMet; AdoMetDC; adoMetDC 1; adoMetDC1; Amd-; Amd-1; MGC102468; MGC91044; S-adenosylmethionine decarboxylase proenzyme 1; SAM; SAMDC; SAMDC 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Amd-ps1   Amd-ps2   Amd-ps3   Amd-ps4   Amd-ps5   Amd-ps6   Amd-ps7   Gm18982   Gm19005   Gm19020  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,163,454 - 40,178,184 (-)NCBIGRCm39mm39
GRCm39 Ensembl1040,163,454 - 40,178,184 (-)Ensembl
GRCm381040,287,458 - 40,302,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,287,458 - 40,302,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv371040,007,265 - 40,021,992 (-)NCBIGRCm37mm9NCBIm37
MGSCv361039,976,874 - 39,991,588 (-)NCBImm8
Celera1036,613,234 - 36,615,716 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1374235   PMID:1449493   PMID:1958536   PMID:8344293   PMID:8889548   PMID:10349636   PMID:10570962   PMID:10829027   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11741992  
PMID:12466851   PMID:12477932   PMID:14681479   PMID:15102471   PMID:15489334   PMID:15917810   PMID:16141072   PMID:16141073   PMID:16153183   PMID:16751776   PMID:17967808   PMID:18583422  
PMID:19131104   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22391449   PMID:28637295   PMID:32968282   PMID:33203990  


Genomics

Comparative Map Data
Amd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,163,454 - 40,178,184 (-)NCBIGRCm39mm39
GRCm39 Ensembl1040,163,454 - 40,178,184 (-)Ensembl
GRCm381040,287,458 - 40,302,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,287,458 - 40,302,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv371040,007,265 - 40,021,992 (-)NCBIGRCm37mm9NCBIm37
MGSCv361039,976,874 - 39,991,588 (-)NCBImm8
Celera1036,613,234 - 36,615,716 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.85NCBI
AMD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6110,874,770 - 110,898,879 (+)EnsemblGRCh38hg38GRCh38
GRCh386110,814,617 - 110,895,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376111,135,820 - 111,216,916 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,302,680 - 111,323,606 (+)NCBINCBI36hg18NCBI36
Build 346111,302,680 - 111,323,599NCBI
Celera6111,942,595 - 111,963,525 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6108,767,311 - 108,788,282 (+)NCBIHuRef
CHM1_16111,459,114 - 111,480,041 (+)NCBICHM1_1
Amd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22043,695,783 - 43,711,476 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2043,697,237 - 43,711,476 (-)Ensembl
Rnor_6.02045,384,000 - 45,399,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,384,000 - 45,399,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02047,103,749 - 47,119,386 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,452,475 - 44,468,111 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12044,475,485 - 44,491,122 (-)NCBI
Celera2044,399,688 - 44,415,381 (-)NCBICelera
Cytogenetic Map20q12NCBI
Amd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541135,541,517 - 35,563,209 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541135,541,517 - 35,563,209 (+)NCBIChiLan1.0ChiLan1.0
AMD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16112,761,072 - 112,782,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6112,761,072 - 112,782,074 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06108,678,741 - 108,699,695 (+)NCBIMhudiblu_PPA_v0panPan3
AMD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11267,432,871 - 67,453,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1267,448,141 - 67,451,696 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,251,123 - 67,272,026 (+)NCBI
ROS_Cfam_1.01268,311,059 - 68,331,965 (+)NCBI
UMICH_Zoey_3.11267,662,003 - 67,682,902 (+)NCBI
UNSW_CanFamBas_1.01267,507,932 - 67,528,835 (+)NCBI
UU_Cfam_GSD_1.01267,786,118 - 67,807,019 (+)NCBI
Amd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946102,381,927 - 102,400,701 (+)NCBI
SpeTri2.0NW_0049365646,656,789 - 6,675,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,839,731 - 76,863,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1176,839,448 - 76,863,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,399,564 - 86,423,858 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11362,977,659 - 62,999,150 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604035,281,244 - 35,302,558 (-)NCBIVero_WHO_p1.0
Amd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249161,837,258 - 1,855,450 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Amd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B2UniSTS
Cytogenetic Map10B1UniSTS
cM Map1021.85UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208561Wght8_mweight 8 (mouse)10500000044000000Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10620194558857699Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10864910542649228Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined101001426844014395Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined101001426844014395Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined101001426844014395Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
10755518Chol16_mcholesterol 16 (mouse)101903904753039047Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102040743956155127Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102250000051200000Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102701426846844387Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:608
Count of miRNA genes:391
Interacting mature miRNAs:471
Transcripts:ENSMUST00000099945
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB025024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC142273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ567245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z14986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000099945   ⟹   ENSMUSP00000097528
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,163,454 - 40,178,182 (-)Ensembl
GRCm38.p6 Ensembl1040,287,458 - 40,302,186 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,165,320 - 40,178,182 (-)Ensembl
GRCm38.p6 Ensembl1040,289,324 - 40,302,186 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214698   ⟹   ENSMUSP00000151015
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,166,214 - 40,177,572 (-)Ensembl
GRCm38.p6 Ensembl1040,290,218 - 40,301,576 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216993
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,170,005 - 40,178,053 (-)Ensembl
GRCm38.p6 Ensembl1040,294,009 - 40,302,057 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238953   ⟹   ENSMUSP00000158947
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,163,454 - 40,178,182 (-)Ensembl
GRCm38.p6 Ensembl1040,287,458 - 40,302,186 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238969   ⟹   ENSMUSP00000159133
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,163,454 - 40,178,184 (-)Ensembl
GRCm38.p6 Ensembl1040,287,458 - 40,302,188 (-)Ensembl
RefSeq Acc Id: NM_009665   ⟹   NP_033795
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391040,163,454 - 40,178,184 (-)NCBI
GRCm381040,287,458 - 40,302,188 (-)ENTREZGENE
MGSCv371040,007,265 - 40,021,992 (-)RGD
Celera1036,613,233 - 36,615,716 (-)NCBI
Celera1041,174,072 - 41,188,801 (-)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033795   ⟸   NM_009665
- UniProtKB: P0DMN7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097528   ⟸   ENSMUST00000099945
RefSeq Acc Id: ENSMUSP00000159133   ⟸   ENSMUST00000238969
RefSeq Acc Id: ENSMUSP00000158947   ⟸   ENSMUST00000238953
RefSeq Acc Id: ENSMUSP00000151015   ⟸   ENSMUST00000214698

Promoters
RGD ID:8671844
Promoter ID:EPDNEW_M13952
Type:single initiation site
Name:Amd1_1
Description:Mus musculus S-adenosylmethionine decarboxylase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381040,302,185 - 40,302,245EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88004 AgrOrtholog
Ensembl Genes ENSMUSG00000075232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000097528 UniProtKB/Swiss-Prot
  ENSMUSP00000151015 UniProtKB/TrEMBL
  ENSMUSP00000158947 UniProtKB/TrEMBL
  ENSMUSP00000159133 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000099945 UniProtKB/Swiss-Prot
  ENSMUST00000214698 UniProtKB/TrEMBL
  ENSMUST00000238953 UniProtKB/TrEMBL
  ENSMUST00000238969 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro S-AdoMet_decarboxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_deCO2ase_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_deCO2ase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11702 UniProtKB/Swiss-Prot
MGD MGI:88004 ENTREZGENE
NCBI Gene 11702 ENTREZGENE
PANTHER PTHR11570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAM_decarbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Amd1 PhenoGen
PIRSF S-AdenosylMet_decarboxylase UniProtKB/Swiss-Prot
PROSITE ADOMETDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56276 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs SAM_DCase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SV28_MOUSE UniProtKB/TrEMBL
  A0A5F8MPF5_MOUSE UniProtKB/TrEMBL
  DCAM1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TJI4_MOUSE UniProtKB/TrEMBL
UniProt Secondary P31154 UniProtKB/Swiss-Prot
  P82184 UniProtKB/Swiss-Prot
  Q58E47 UniProtKB/Swiss-Prot