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ONTOLOGY REPORT - ANNOTATIONS


Term:reserpine
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Accession:CHEBI:28487 term browser browse the term
Definition:An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Synonyms:exact_synonym: methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
 related_synonym: (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;   3,4,5-trimethoxybenzoyl methyl reserpate;   Apoplon;   Formula=C33H40N2O9;   InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1;   InChIKey=QEVHRUUCFGRFIF-MDEJGZGSSA-N;   Reserpin;   SMILES=[H][C@]12C[C@@H](OC(=O)c3cc(OC)c(OC)c(OC)c3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCc3c1[nH]c1cc(OC)ccc31)C2;   Serpalan
 alt_id: CHEBI:26531;   CHEBI:8808
 xref: Beilstein:102014 "Beilstein";   Beilstein:5326088 "Beilstein";   CAS:50-55-5 "ChemIDplus";   CAS:50-55-5 "KEGG COMPOUND";   CAS:50-55-5 "NIST Chemistry WebBook";   DrugBank:DB00206;   Drug_Central:2370 "DrugCentral";   HMDB:HMDB0014351;   KEGG:C06539;   KEGG:D00197;   KNApSAcK:C00001763;   LINCS:LSM-4162
 xref_mesh: MESH:D012110
 xref: PMID:20701244 "Europe PMC";   PMID:20825390 "Europe PMC";   PMID:24603678 "Europe PMC";   Reaxys:102014 "Reaxys";   Wikipedia:Reserpine


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reserpine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 JBrowse link 2 69,238,282 69,342,616 RGD:6480464
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 6 58,584,491 58,692,451 RGD:6480464
G Adra1d adrenergic receptor, alpha 1d JBrowse link 2 131,545,357 131,562,497 RGD:6480464
G Adra2a adrenergic receptor, alpha 2a JBrowse link 19 54,045,259 54,048,982 RGD:6480464
G Adrb1 adrenergic receptor, beta 1 JBrowse link 19 56,722,117 56,725,150 RGD:6480464
G Adrb2 adrenergic receptor, beta 2 JBrowse link 18 62,177,713 62,179,981 RGD:6480464
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 21,484,549 21,488,833 RGD:6480464
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) JBrowse link 6 34,384,247 34,396,949 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Amd1 S-adenosylmethionine decarboxylase 1 JBrowse link 10 40,287,458 40,302,188 RGD:6480464
G Ar androgen receptor JBrowse link X 98,148,757 98,323,218 RGD:6480464
G Arc activity regulated cytoskeletal-associated protein JBrowse link 15 74,669,081 74,672,570 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 11 117,849,237 117,855,743 RGD:6480464
G C3 complement component 3 JBrowse link 17 57,203,967 57,228,136 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:6480464
G Cdkn2a cyclin dependent kinase inhibitor 2A JBrowse link 4 89,274,473 89,294,619 RGD:6480464
G Chga chromogranin A JBrowse link 12 102,554,941 102,565,027 RGD:6480464
G Chgb chromogranin B JBrowse link 2 132,781,642 132,795,079 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1, CNS JBrowse link 19 8,664,005 8,683,606 RGD:6480464
G Cnr1 cannabinoid receptor 1 (brain) JBrowse link 4 33,923,171 33,948,831 RGD:6480464
G Cpe carboxypeptidase E JBrowse link 8 64,592,542 64,693,109 RGD:6480464
G Crem cAMP responsive element modulator JBrowse link 18 3,266,354 3,337,773 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 9 57,687,928 57,703,824 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 9 57,676,937 57,683,655 RGD:6480464
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 JBrowse link 7 25,897,658 25,926,624 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 JBrowse link 5 137,892,933 137,925,610 RGD:6480464
G Dbh dopamine beta hydroxylase JBrowse link 2 27,165,507 27,183,204 RGD:6480464
G Ddc dopa decarboxylase JBrowse link 11 11,814,101 11,898,144 RGD:6480464
G Drd1 dopamine receptor D1 JBrowse link 13 54,051,183 54,055,658 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 9 49,340,360 49,408,177 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 11 98,412,484 98,437,716 RGD:6480464
G Fabp7 fatty acid binding protein 7, brain JBrowse link 10 57,784,923 57,788,450 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Gad1 glutamate decarboxylase 1 JBrowse link 2 70,561,303 70,602,014 RGD:6480464
G Gal galanin and GMAP prepropeptide JBrowse link 19 3,409,915 3,414,544 RGD:6480464
G Gast gastrin JBrowse link 11 100,334,407 100,336,997 RGD:6480464
G Gch1 GTP cyclohydrolase 1 JBrowse link 14 47,153,895 47,189,413 RGD:6480464
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type JBrowse link 9 70,031,495 70,039,890 RGD:6480464
G Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 JBrowse link 5 18,265,135 18,360,413 RGD:6480464
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 JBrowse link 9 107,614,125 107,635,391 RGD:6480464
G Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 JBrowse link 3 108,107,275 108,146,152 RGD:6480464
G Gnao1 guanine nucleotide binding protein, alpha O JBrowse link 8 93,810,153 93,969,388 RGD:6480464
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus JBrowse link 2 174,284,320 174,346,744 RGD:6480464
G Grm5 glutamate receptor, metabotropic 5 JBrowse link 7 87,583,981 88,135,063 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 5 16,553,495 16,619,439 RGD:6480464
G Hspg2 perlecan (heparan sulfate proteoglycan 2) JBrowse link 4 137,468,751 137,570,630 RGD:6480464
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A JBrowse link 13 105,443,693 105,448,133 RGD:6480464
G Iapp islet amyloid polypeptide JBrowse link 6 142,298,425 142,303,820 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il18 interleukin 18 JBrowse link 9 50,554,700 50,581,841 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Junb jun B proto-oncogene JBrowse link 8 84,976,909 84,978,748 RGD:6480464
G Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 JBrowse link 3 107,036,162 107,038,129 RGD:6480464
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 JBrowse link 6 126,532,551 126,535,555 RGD:6480464
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 JBrowse link 6 21,215,346 21,729,805 RGD:6480464
G Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 JBrowse link 3 105,451,890 105,674,002 RGD:6480464
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 JBrowse link 5 24,319,589 24,351,684 RGD:6480464
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 5 134,220,053 134,229,628 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Ngf nerve growth factor JBrowse link 3 102,469,919 102,521,013 RGD:6480464
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:6480464
G Npy neuropeptide Y JBrowse link 6 49,822,710 49,829,507 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 16 38,248,349 38,294,849 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 1 171,213,934 171,218,845 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 39,410,545 39,519,421 RGD:6480464
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 JBrowse link 13 58,806,472 59,133,970 RGD:6480464
G Nts neurotensin JBrowse link 10 102,481,756 102,490,418 RGD:6480464
G Odc1 ornithine decarboxylase, structural 1 JBrowse link 12 17,544,808 17,551,502 RGD:6480464
G Pam peptidylglycine alpha-amidating monooxygenase JBrowse link 1 97,821,091 98,095,853 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 2 132,249,286 132,253,180 RGD:6480464
G Pcsk2 proprotein convertase subtilisin/kexin type 2 JBrowse link 2 143,546,133 143,816,284 RGD:6480464
G Penk preproenkephalin JBrowse link 4 4,133,536 4,138,815 RGD:6480464
G Pnmt phenylethanolamine-N-methyltransferase JBrowse link 11 98,386,623 98,388,180 RGD:6480464
G Pomc pro-opiomelanocortin-alpha JBrowse link 12 3,954,945 3,960,643 RGD:6480464
G Prkaca protein kinase, cAMP dependent, catalytic, alpha JBrowse link 8 83,972,978 83,996,444 RGD:6480464
G Prl prolactin JBrowse link 13 27,057,570 27,065,204 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Pts 6-pyruvoyl-tetrahydropterin synthase JBrowse link 9 50,521,617 50,528,716 RGD:6480464
G Rasd2 RASD family, member 2 JBrowse link 8 75,213,944 75,224,113 RGD:6480464
G Rgs10 regulator of G-protein signalling 10 JBrowse link 7 128,373,621 128,419,506 RGD:6480464
G Rgs2 regulator of G-protein signaling 2 JBrowse link 1 143,999,338 144,004,149 RGD:6480464
G Rgs4 regulator of G-protein signaling 4 JBrowse link 1 169,741,477 169,747,642 RGD:6480464
G Rgs5 regulator of G-protein signaling 5 JBrowse link 1 169,655,501 169,695,813 RGD:6480464
G Rgs8 regulator of G-protein signaling 8 JBrowse link 1 153,652,959 153,697,669 RGD:6480464
G Rgs9 regulator of G-protein signaling 9 JBrowse link 11 109,225,348 109,298,181 RGD:6480464
G Scg2 secretogranin II JBrowse link 1 79,434,366 79,440,026 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Siah1a siah E3 ubiquitin protein ligase 1A JBrowse link 8 86,720,454 86,746,006 RGD:6480464
G Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 JBrowse link 8 69,037,708 69,089,238 RGD:6480464
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 JBrowse link 19 59,260,878 59,296,012 RGD:6480464
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 JBrowse link 8 92,960,470 93,001,667 RGD:6480464
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 JBrowse link 13 73,536,128 73,578,672 RGD:6480464
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 JBrowse link 11 76,998,597 77,032,343 RGD:6480464
G Snca synuclein, alpha JBrowse link 6 60,731,573 60,829,855 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 11 50,200,152 50,210,820 RGD:6480464
G Syt7 synaptotagmin VII JBrowse link 19 10,388,802 10,453,181 RGD:6480464
G Tac1 tachykinin 1 JBrowse link 6 7,555,061 7,562,978 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 7 142,892,779 142,899,995 RGD:6480464
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 JBrowse link 3 27,317,077 27,339,665 RGD:6480464
G Tph1 tryptophan hydroxylase 1 JBrowse link 7 46,644,641 46,672,537 RGD:6480464
G Try10 trypsin 10 JBrowse link 6 41,354,105 41,357,944 RGD:6480464
G Vgf VGF nerve growth factor inducible JBrowse link 5 137,025,301 137,033,351 RGD:6480464
G Vip vasoactive intestinal polypeptide JBrowse link 10 5,639,193 5,647,617 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21021
    role 21002
      biological role 21000
        xenobiotic 18860
          reserpine 116
Path 2
Term Annotations click to browse term
  CHEBI ontology 21021
    subatomic particle 21015
      composite particle 21015
        hadron 21015
          baryon 21015
            nucleon 21015
              atomic nucleus 21015
                atom 21015
                  main group element atom 20858
                    p-block element atom 20858
                      carbon group element atom 20599
                        carbon atom 20576
                          organic molecular entity 20576
                            organic group 19171
                              cyclic organic group 1858
                                organic heterobicyclic ring 1858
                                  indole skeleton 1858
                                    indole alkaloid 1858
                                      terpenoid indole alkaloid 1487
                                        monoterpenoid indole alkaloid 1477
                                          yohimban alkaloid 157
                                            reserpic acid 116
                                              reserpine 116
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.