Kcna3 (potassium voltage-gated channel, shaker-related subfamily, member 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Kcna3 (potassium voltage-gated channel, shaker-related subfamily, member 3) Mus musculus
Analyze
Symbol: Kcna3
Name: potassium voltage-gated channel, shaker-related subfamily, member 3
RGD ID: 736591
MGI Page MGI
Description: Predicted to enable delayed rectifier potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Located in axon. Is expressed in brain and heart. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kca1-; Kca1-3; Kv1.; Kv1.3; Mk-3; MK3; potassium voltage gated channel, shaker related subfamily, member 3; potassium voltage-gated channel subfamily A member 3; Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3); voltage-gated potassium channel subunit Kv1.3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,943,486 - 106,947,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,943,485 - 106,945,386 (+)EnsemblGRCm39 Ensembl
GRCm383107,036,162 - 107,038,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,036,169 - 107,038,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,839,080 - 106,841,047 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,164,479 - 107,166,065 (+)NCBIMGSCv36mm8
Celera3109,365,430 - 109,367,397 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. [Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh]. Zhang QB, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1020-4.
Additional References at PubMed
PMID:1383027   PMID:2251283   PMID:2305265   PMID:2333511   PMID:7829094   PMID:7905852   PMID:8034307   PMID:9286706   PMID:9488722   PMID:12477932   PMID:12588802   PMID:12878608  
PMID:12923194   PMID:14686897   PMID:14766178   PMID:14981264   PMID:15304346   PMID:16141072   PMID:16403947   PMID:16985003   PMID:17038323   PMID:17157812   PMID:18022950   PMID:18218624  
PMID:18542083   PMID:18818304   PMID:19166614   PMID:19458242   PMID:19477198   PMID:19707551   PMID:20299686   PMID:20308249   PMID:20393063   PMID:20575068   PMID:20691762   PMID:20884640  
PMID:21233214   PMID:21267068   PMID:21282332   PMID:21575593   PMID:21586699   PMID:21859894   PMID:21873635   PMID:21966386   PMID:22383699   PMID:22435906   PMID:22581856   PMID:22978806  
PMID:23063513   PMID:23478133   PMID:23485739   PMID:23729813   PMID:23821603   PMID:23933188   PMID:24244345   PMID:24249731   PMID:24344200   PMID:24828650   PMID:25644777   PMID:26150529  
PMID:26213925   PMID:26354506   PMID:26542799   PMID:26748289   PMID:26795234   PMID:27242550   PMID:27439875   PMID:27507650   PMID:27568555   PMID:27696527   PMID:27798109   PMID:27802162  
PMID:28283561   PMID:28671696   PMID:29615878   PMID:29947924   PMID:30043400   PMID:31646751   PMID:31661467   PMID:32597830   PMID:32787516   PMID:32910509   PMID:32956412   PMID:33230847  
PMID:33649184   PMID:33669857   PMID:33881519   PMID:34321999   PMID:36100082   PMID:36455670   PMID:36604605   PMID:36808153   PMID:37591369  


Genomics

Comparative Map Data
Kcna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,943,486 - 106,947,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,943,485 - 106,945,386 (+)EnsemblGRCm39 Ensembl
GRCm383107,036,162 - 107,038,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,036,169 - 107,038,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,839,080 - 106,841,047 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,164,479 - 107,166,065 (+)NCBIMGSCv36mm8
Celera3109,365,430 - 109,367,397 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.59NCBI
KCNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,653,560 - 110,674,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,653,560 - 110,674,940 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,196,182 - 111,217,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,015,833 - 111,019,178 (-)NCBINCBI36Build 36hg18NCBI36
Build 341110,926,351 - 110,929,697NCBI
Celera1109,461,411 - 109,464,756 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1109,085,699 - 109,089,044 (-)NCBIHuRef
CHM1_11111,329,439 - 111,332,784 (-)NCBICHM1_1
T2T-CHM13v2.01110,668,304 - 110,689,683 (-)NCBIT2T-CHM13v2.0
Kcna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,320,324 - 197,322,277 (+)NCBIGRCr8
mRatBN7.22194,632,106 - 194,634,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,632,196 - 194,650,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,264,409 - 202,265,986 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,158,435 - 200,160,012 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02194,975,390 - 194,976,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,766,767 - 209,768,344 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,766,512 - 209,769,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,233,084 - 229,234,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,472,638 - 202,474,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,435,391 - 202,436,969 (+)NCBI
Celera2187,293,280 - 187,294,857 (+)NCBICelera
Cytogenetic Map2q34NCBI
Kcna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,147,454 - 14,148,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,132,877 - 14,148,911 (-)NCBIChiLan1.0ChiLan1.0
KCNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,366,047 - 116,384,339 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,513,619 - 115,531,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,304,340 - 113,323,367 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,021,508 - 127,042,481 (+)NCBIpanpan1.1PanPan1.1panPan2
KCNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,343,613 - 41,363,076 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,120,679 - 44,140,399 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,675,464 - 41,695,170 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,675,383 - 41,677,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,395,369 - 41,415,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,366,130 - 41,385,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,801,395 - 41,821,138 (+)NCBIUU_Cfam_GSD_1.0
Kcna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,028,223 - 18,047,417 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,084,436 - 2,085,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,083,037 - 2,085,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,495,350 - 109,497,116 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,495,220 - 109,498,548 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,860,978 - 119,877,340 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,869,388 - 22,885,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,870,880 - 22,872,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,569,291 - 35,590,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,364,325 - 6,376,208 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,360,169 - 6,376,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcna3
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:100
Interacting mature miRNAs:106
Transcripts:ENSMUST00000052718
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse

Markers in Region
Kcna1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386126,643,102 - 126,643,216UniSTSGRCm38
GRCm383107,036,622 - 107,036,737UniSTSGRCm38
MGSCv376126,593,120 - 126,593,234UniSTSGRCm37
MGSCv373106,839,540 - 106,839,655UniSTSGRCm37
Celera6128,312,702 - 128,312,816UniSTS
Celera3109,365,890 - 109,366,005UniSTS
Cytogenetic Map3F2.3UniSTS
Cytogenetic Map6F1-F3UniSTS
cM Map661.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000052718   ⟹   ENSMUSP00000050680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3106,943,485 - 106,945,386 (+)Ensembl
GRCm38.p6 Ensembl3107,036,169 - 107,038,070 (+)Ensembl
RefSeq Acc Id: NM_008418   ⟹   NP_032444
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393106,943,486 - 106,947,223 (+)NCBI
GRCm383107,036,162 - 107,038,129 (+)ENTREZGENE
MGSCv373106,839,080 - 106,841,047 (+)RGD
Celera3109,365,430 - 109,367,397 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA39716 (Get FASTA)   NCBI Sequence Viewer  
  AAI32350 (Get FASTA)   NCBI Sequence Viewer  
  AAI37668 (Get FASTA)   NCBI Sequence Viewer  
  EDL01888 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000050680
  ENSMUSP00000050680.4
GenBank Protein P16390 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032444   ⟸   NM_008418
- UniProtKB: A3KMM2 (UniProtKB/Swiss-Prot),   P16390 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000050680   ⟸   ENSMUST00000052718

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16390-F1-model_v2 AlphaFold P16390 1-528 view protein structure

Promoters
RGD ID:6833991
Promoter ID:MM_KWN:35697
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   Spleen
Transcripts:NM_008418
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363106,839,116 - 106,839,962 (+)MPROMDB
RGD ID:6881990
Promoter ID:EPDNEW_M4446
Type:multiple initiation site
Name:Kcna3_1
Description:Mus musculus potassium voltage-gated channel, shaker-relatedsubfamily, member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383107,036,170 - 107,036,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96660 AgrOrtholog
Ensembl Genes ENSMUSG00000047959 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052718 ENTREZGENE
  ENSMUST00000052718.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv1.3 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:16491 UniProtKB/Swiss-Prot
MGD MGI:96660 ENTREZGENE
NCBI Gene 16491 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 3 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Kcna3 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV13CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHAKERCHANEL UniProtKB/Swiss-Prot
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A3KMM2 ENTREZGENE
  KCNA3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A3KMM2 UniProtKB/Swiss-Prot