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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terpenoid indole alkaloid
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Accession:CHEBI:65321 term browser browse the term
Definition:An indole alkaloid which is biosynthesised from L-tryptophan and isoprenoid building blocks.
Synonyms:related_synonym: terpenoid indole alkaloids


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ajmalicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO raubasine results in decreased activity of CYP2D6 protein
raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CTD PMID:15930738 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
ajmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Ajmaline results in decreased activity of KCNH2 protein CTD PMID:15599706, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity
affects response to substance
ISO Ajmaline results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Ajmaline
CTD PMID:10662748, PMID:15520322, PMID:20174578 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
alpha-ergocryptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergocryptine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
brucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein multiple interactions EXP brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:24060683 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO brucine results in increased expression of BAX protein CTD PMID:16443926, PMID:21684292 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO brucine results in decreased expression of BCL2 protein CTD PMID:16443926 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO [brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP3 protein
brucine results in increased expression of CASP3 protein
brucine results in increased expression of and results in increased activity of CASP3 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]
CTD PMID:16442763, PMID:16443926, PMID:17449162, PMID:21684292 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO brucine results in increased activity of and results in increased cleavage of CASP9 protein; Cyclosporine inhibits the reaction [[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [brucine results in increased activity of and results in increased cleavage of CASP9 protein]
[brucine results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; brucine results in increased activity of CASP9 protein
CTD PMID:16443926, PMID:21684292 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP brucine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] CTD PMID:24060683 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO brucine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM1 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; brucine promotes the reaction [Bethanechol binds to CHRM1 protein]; brucine promotes the reaction [Carbachol binds to CHRM1 protein]; brucine promotes the reaction [furtrethonium binds to CHRM1 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM1 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]] CTD PMID:9224827, PMID:9495826, PMID:10069518, PMID:10101037, PMID:15294002, PMID:16439611 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
affects binding
ISO brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM2 protein]; brucine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
brucine binds to CHRM2 protein
CTD PMID:9495826, PMID:10069518, PMID:15647330 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding
ISO brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM3 protein]; brucine binds to and results in increased activity of CHRM3 protein mutant form; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM3 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Arecoline binds to CHRM3 protein]; brucine promotes the reaction [Bethanechol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; brucine promotes the reaction [furtrethonium binds to CHRM3 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM3 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
brucine binds to CHRM3 protein
CTD PMID:9224827, PMID:10069518, PMID:15647330, PMID:20466821 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM4 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM4 protein]; brucine promotes the reaction [Bethanechol binds to CHRM4 protein]; brucine promotes the reaction [Carbachol binds to CHRM4 protein]; brucine promotes the reaction [furtrethonium binds to CHRM4 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM4 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; WIN 62577 inhibits the reaction [brucine binds to CHRM4 protein] CTD PMID:9224827, PMID:10069518, PMID:16709648 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Ctsd cathepsin D decreases expression ISO brucine results in decreased expression of CTSD mRNA
brucine results in decreased expression of CTSD mRNA; brucine results in decreased expression of CTSD protein
CTD PMID:23933019 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein CTD PMID:21800547 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP brucine results in increased expression of CYP2B1 protein CTD PMID:7906730 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP brucine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression EXP brucine results in increased expression of CYP2B3 protein CTD PMID:8850324 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein; [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein
brucine results in increased activity of CYP2E1 protein
CTD PMID:21800547 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO brucine results in decreased expression of FN1 mRNA
brucine results in decreased expression of FN1 mRNA; brucine results in decreased expression of FN1 protein
CTD PMID:23933019 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO brucine analog binds to and results in decreased activity of GLRA1 protein; brucine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878, PMID:16687139 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO brucine results in increased expression of GPT protein CTD PMID:31284022 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Lox lysyl oxidase decreases expression ISO brucine results in decreased expression of LOX mRNA
brucine results in decreased expression of LOX mRNA; brucine results in decreased expression of LOX protein
CTD PMID:23933019 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Mbp myelin basic protein affects expression EXP brucine affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO brucine results in decreased expression of MMP2 mRNA
brucine results in decreased expression of MMP2 mRNA; brucine results in decreased expression of MMP2 protein
CTD PMID:23933019 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions ISO NPAS2 protein affects the metabolism of and affects the susceptibility to brucine CTD PMID:31284022 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP brucine inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:24060683 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO brucine results in decreased expression of PTGS2 protein CTD PMID:16442763, PMID:17449162 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO brucine results in decreased secretion of TNF protein CTD PMID:21684292 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
caracurine VII term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2 affects binding ISO caracurine binds to CHRM2 protein CTD PMID:15647330 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding ISO caracurine binds to CHRM3 protein CTD PMID:15647330 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
dihydroergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Dihydroergotamine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Dihydroergotamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
ISO
EXP
Dihydroergotamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Dihydroergotamine results in decreased activity of CYP1A1 protein
Dihydroergotamine results in increased activity of CYP1A1 protein
CTD PMID:18420780, PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Dihydroergotamine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Dihydroergotamine results in decreased activity of CYP2D6 protein
Dihydroergotamine results in decreased activity of CYP2D22 protein
CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dihydroergotamine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
ergocristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO ergocristine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ergocristine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Casp3 caspase 3 increases activity ISO ergocristine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
ergosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
ergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] CTD PMID:19121572 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 increases activity ISO Ergotamine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] CTD PMID:19121572 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Ergotamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions ISO Ergotamine binds to and results in increased activity of HTR2B protein CTD PMID:11104741 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
fumigaclavine C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO fumigaclavine C results in decreased expression of IFNG mRNA; fumigaclavine C results in decreased expression of IFNG protein CTD PMID:16023606 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12a interleukin 12A decreases expression ISO fumigaclavine C results in decreased expression of IL12A mRNA CTD PMID:16023606 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO fumigaclavine C results in decreased expression of IL1B mRNA CTD PMID:16023606 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression ISO fumigaclavine C results in decreased expression of IL2 mRNA; fumigaclavine C results in decreased expression of IL2 protein CTD PMID:16023606 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression
ISO fumigaclavine C results in decreased activity of MMP9 protein
fumigaclavine C results in decreased expression of MMP9 mRNA
CTD PMID:16023606 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO fumigaclavine C results in decreased expression of TNF mRNA CTD PMID:16023606 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
ibogaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Ibogaine results in decreased activity of KCNH2 protein CTD PMID:23707769, PMID:24307198 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Ibogaine results in decreased activity of SCN5A protein CTD PMID:23707769 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases response to substance ISO SEC24D protein results in increased susceptibility to Ibogaine CTD PMID:27555326 NCBI chr 2:227,455,704...227,562,801
Ensembl chr 2:227,455,722...227,562,319
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases expression
ISO Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein
CTD PMID:27555326 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
icajine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO icajine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2b 5-hydroxytryptamine receptor 2B affects binding
multiple interactions
ISO mesulergine binds to HTR2B protein
Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]
CTD PMID:11930908 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
ISO
EXP
mesulergine binds to HTR2C protein
N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein]
Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]
CTD PMID:18083778, PMID:19439326, PMID:19700373, PMID:29458138 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO mesulergine binds to HTR7 protein
[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406, PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Prl prolactin multiple interactions EXP mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein] CTD PMID:1421203 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
methysergide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Methysergide results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity EXP Methysergide affects the activity of CALCA protein CTD PMID:10075105 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP Methysergide binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
Mitragynine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects activity ISO mitragynine affects the activity of ABCG2 protein CTD PMID:30083819 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of mitragynine CTD PMID:25445008 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
ISO mitragynine results in increased activity of CYP1A2 protein
mitragynine results in increased expression of CYP1A2 mRNA; mitragynine results in increased expression of CYP1A2 protein
CTD PMID:23274770 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO mitragynine results in decreased activity of CYP2C19 protein CTD PMID:31707106 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression
decreases activity
ISO mitragynine results in increased expression of CYP2D6 protein
mitragynine results in decreased activity of CYP2D6 protein
CTD PMID:23274770, PMID:31707106 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression
multiple interactions
ISO mitragynine results in decreased expression of KCNH2 protein
mitragynine binds to and results in decreased activity of KCNH2 protein
CTD PMID:27260674 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding ISO mitragynine binds to OPRD1 protein CTD PMID:27192616 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
ISO mitragynine binds to OPRK1 protein
mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
CTD PMID:27192616 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO mitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; mitragynine binds to and results in increased activity of OPRM1 protein; mitragynine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]
mitragynine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
mitragynine binds to OPRM1 protein
CTD PMID:23608241, PMID:27192616 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO mitragynine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein] CTD PMID:21513785 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO mitragynine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; mitragynine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:21513785 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
rescinnamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO rescinnamine results in increased expression of ABCB1 mRNA CTD PMID:7476894 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO rescinnamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
reserpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Reserpine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Reserpine results in decreased activity of ABCB11 protein
CTD PMID:20829430, PMID:23956101, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases activity
ISO Cycloheximide promotes the reaction [Reserpine results in increased expression of ABCB1 mRNA]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
Reserpine results in increased expression of ABCB1 mRNA; Reserpine results in increased expression of ABCB1 protein
Reserpine results in decreased activity of ABCB1 protein
CTD PMID:7476894, PMID:8632764, PMID:10617675, PMID:12235267, PMID:19528478 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of Irinotecan] CTD PMID:12869632 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adra1d adrenoceptor alpha 1D increases response to substance
increases expression
EXP ADRA1D protein results in increased susceptibility to Reserpine
Reserpine results in increased expression of ADRA1D mRNA
CTD PMID:15159276, PMID:17676312 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP Reserpine results in increased expression of ADRA2A mRNA CTD PMID:11264240 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression
increases stability
EXP Reserpine results in increased expression of ADRB1 mRNA; Reserpine results in increased expression of ADRB1 protein
Reserpine results in increased stability of ADRB1 mRNA
CTD PMID:1336118 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Reserpine results in increased expression of ADRB2 mRNA CTD PMID:1664493 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Reserpine results in increased expression of AGTR2 mRNA; Reserpine results in increased expression of AGTR2 protein CTD PMID:20964730 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Reserpine results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Reserpine results in decreased phosphorylation of AKT1 protein
arsenic trioxide promotes the reaction [Reserpine results in decreased phosphorylation of AKT1 protein]
CTD PMID:26114099 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO Reserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein] CTD PMID:17371283 NCBI chr20:45,384,000...45,399,694
Ensembl chr20:45,384,000...45,399,694
JBrowse link
G Ar androgen receptor multiple interactions ISO Reserpine inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions EXP Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA] CTD PMID:7722525 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein] CTD PMID:19463876 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein] CTD PMID:19463876 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO Reserpine results in decreased expression of BDNF protein
arsenic trioxide promotes the reaction [Reserpine results in decreased expression of BDNF protein]
CTD PMID:26114099 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Reserpine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G C3 complement C3 affects expression EXP Reserpine affects the expression of C3 mRNA CTD PMID:18363858 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein] CTD PMID:19463876 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
EXP IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein] CTD PMID:19463876 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions
decreases expression
increases expression
EXP Plant Extracts inhibits the reaction [Reserpine results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Reserpine results in decreased expression of CAT protein]
Reserpine results in increased expression of CAT protein
CTD PMID:14685008, PMID:16444668, PMID:19109989, PMID:19761039, PMID:20628966 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Reserpine results in decreased expression of CCND1 mRNA; Reserpine results in decreased expression of CCND1 protein CTD PMID:19607803 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Chga chromogranin A multiple interactions
increases expression
increases activity
ISO
EXP
CHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]
Reserpine results in increased expression of CHGA mRNA
CTD PMID:1907749, PMID:8189248, PMID:12799369 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Chgb chromogranin B increases expression EXP Reserpine results in increased expression of CHGB mRNA; Reserpine results in increased expression of CHGB protein CTD PMID:1907749, PMID:8189248, PMID:8361347 NCBI chr 3:125,428,050...125,441,601
Ensembl chr 3:125,428,260...125,441,594
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression
decreases expression
EXP Reserpine results in increased expression of CHRM1 mRNA
Reserpine results in decreased expression of CHRM1 protein
CTD PMID:1506860 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Reserpine results in decreased expression of CNR1 mRNA CTD PMID:11358453 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cpe carboxypeptidase E increases expression EXP Reserpine results in increased expression of CPE mRNA CTD PMID:8189248 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Crem cAMP responsive element modulator multiple interactions
increases expression
EXP Reserpine promotes the reaction [CREM protein binds to TH promoter]
Reserpine results in increased expression of CREM mRNA alternative form; Reserpine results in increased expression of CREM protein; Reserpine results in increased expression of CREM protein alternative form
CTD PMID:8810303, PMID:11438978 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crh corticotropin releasing hormone increases expression EXP Reserpine results in increased expression of CRH mRNA; Reserpine results in increased expression of CRH protein CTD PMID:1850078 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Reserpine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15627480, PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:16510159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Reserpine results in increased expression of CYP3A5 protein CTD PMID:8632764 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyss cystatin S multiple interactions EXP Reserpine inhibits the reaction [Isoproterenol results in increased expression of CYSS mRNA] CTD PMID:9447264 NCBI chr 3:144,427,430...144,431,768
Ensembl chr 3:144,427,207...144,431,806
JBrowse link
G Dbh dopamine beta-hydroxylase decreases activity
increases expression
increases stability
increases activity
EXP Reserpine results in decreased activity of DBH protein
Reserpine results in increased expression of DBH mRNA
Reserpine results in increased stability of DBH protein
Reserpine results in increased activity of DBH protein
CTD PMID:1359376, PMID:2325165, PMID:7984052, PMID:8189248 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Ddc dopa decarboxylase increases expression EXP Reserpine results in increased expression of DDC mRNA CTD PMID:1359376 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Reserpine results in increased expression of DRD1 mRNA CTD PMID:8419537 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases expression
ISO
EXP
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
Reserpine results in increased expression of DRD2 mRNA; Reserpine results in increased expression of DRD2 mRNA alternative form
CTD PMID:1331675, PMID:8419537, PMID:11172060 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
EXP [Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA; eticlopride inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA]; Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]]
Reserpine results in increased expression of EGR1 mRNA; Reserpine results in increased expression of EGR1 protein
CTD PMID:1347779, PMID:8063705, PMID:9729266, PMID:9890435 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases response to substance EXP ERBB2 protein results in increased susceptibility to Reserpine CTD PMID:8093862 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression EXP Reserpine affects the expression of FABP7 mRNA CTD PMID:18363858 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases phosphorylation
EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine promotes the reaction [Reserpine results in increased expression of FOS protein]; 3,7-dimethyl-1-propargylxanthine inhibits the reaction [Reserpine results in increased expression of FOS protein]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; Reserpine promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein]; Reserpine promotes the reaction [Amphetamine results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]
Reserpine results in increased expression of FOS mRNA; Reserpine results in increased expression of FOS protein
Reserpine results in increased phosphorylation of FOS protein
CTD PMID:1359376, PMID:1686849, PMID:2118661, PMID:7845612, PMID:7914358, PMID:8100600, PMID:8102797, PMID:8577368, PMID:8864302, PMID:9210518 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions
EXP Reserpine results in increased expression of GAD1 mRNA
Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]
CTD PMID:8774452 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression
increases expression
multiple interactions
EXP Reserpine results in decreased expression of GAL mRNA
Reserpine results in increased expression of GAL mRNA
Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA]
CTD PMID:1279347, PMID:1698642, PMID:1705056, PMID:1717808, PMID:9512271, PMID:19598284 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gast gastrin multiple interactions EXP Reserpine inhibits the reaction [Levodopa results in decreased cleavage of GAST protein] CTD PMID:10332097 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Reserpine results in increased expression of GCH1 mRNA; Reserpine results in increased expression of GCH1 mRNA alternative form CTD PMID:8103077 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO Reserpine results in increased expression of GCNT3 mRNA CTD PMID:26198647 NCBI chr 8:76,449,078...76,459,431
Ensembl chr 8:76,449,081...76,452,554
JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression EXP Reserpine results in increased expression of GNAI1 protein CTD PMID:11264240 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression EXP Reserpine results in increased expression of GNAI2 mRNA; Reserpine results in increased expression of GNAI2 protein CTD PMID:8419537, PMID:11264240 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression EXP Reserpine results in increased expression of GNAI3 protein CTD PMID:11264240 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gnao1 G protein subunit alpha o1 increases expression EXP Reserpine results in increased expression of GNAO1 mRNA; Reserpine results in increased expression of GNAO1 protein CTD PMID:8419537, PMID:11264240 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Gnas GNAS complex locus increases expression
decreases expression
EXP Reserpine results in increased expression of GNAS mRNA; Reserpine results in increased expression of GNAS protein
Reserpine results in decreased expression of GNAS protein alternative form
CTD PMID:1336118, PMID:8419537, PMID:11264240 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Grm5 glutamate metabotropic receptor 5 decreases expression
increases expression
EXP Reserpine results in decreased expression of GRM5 mRNA
Reserpine results in increased expression of GRM5 protein
CTD PMID:16890937 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Reserpine results in increased expression of HGF protein CTD PMID:16081063 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 multiple interactions ISO HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine] CTD PMID:20072119 NCBI chr 5:155,812,096...155,913,751 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression ISO Reserpine results in decreased expression of HTR1A protein CTD PMID:26114099 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
ISO Reserpine results in decreased expression of IL10 mRNA; Reserpine results in decreased expression of IL10 protein
SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA]; SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein]
CTD PMID:16985181 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 increases expression EXP Reserpine results in increased expression of IL18 mRNA CTD PMID:8999896 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Reserpine results in increased expression of JUN mRNA CTD PMID:1359376 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]] CTD PMID:1347779 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions
ISO Reserpine results in decreased activity of KCNA3 protein
[Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 2:209,766,767...209,768,344
Ensembl chr 2:209,766,512...209,769,711
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression EXP Reserpine results in increased expression of KCNA5 mRNA CTD PMID:12606256 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 decreases expression EXP Reserpine results in decreased expression of KCND2 mRNA CTD PMID:12606256 NCBI chr 4:48,309,283...48,816,804 JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 decreases expression EXP Reserpine results in decreased expression of KCND3 mRNA CTD PMID:12606256 NCBI chr 2:207,923,775...208,140,727
Ensembl chr 2:207,923,775...208,140,727
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Reserpine results in decreased activity of KCNH2 protein
[Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium
CTD PMID:21362439, PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lep leptin increases expression ISO Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases response to substance
decreases expression
ISO MYC protein results in increased susceptibility to Reserpine
Reserpine results in decreased expression of MYC protein
CTD PMID:8093862, PMID:19607803 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression EXP Reserpine results in increased expression of NCF1 mRNA; Reserpine results in increased expression of NCF1 protein CTD PMID:20964730 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases activity ISO Reserpine results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor increases expression EXP Reserpine results in increased expression of NGF mRNA; Reserpine results in increased expression of NGF protein CTD PMID:1996081, PMID:8593794 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP Reserpine results in increased expression of NOS1 mRNA; Reserpine results in increased expression of NOS1 protein CTD PMID:7533141 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Npy neuropeptide Y multiple interactions
increases expression
decreases expression
EXP Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]; Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]
Reserpine results in increased expression of NPY mRNA; Reserpine results in increased expression of NPY protein
Reserpine results in decreased expression of NPY mRNA; Reserpine results in decreased expression of NPY protein
CTD PMID:1671012, PMID:1676830, PMID:1687976, PMID:1698642, PMID:1713314, PMID:1714554, PMID:1878751, PMID:1907749, PMID:2233698, PMID:2897091, PMID:2903502, PMID:3215285, PMID:3805164, PMID:7644023, PMID:7911764, PMID:8189248, PMID:20504635 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
ISO [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
Reserpine results in decreased activity of NR1I3 protein
CTD PMID:17041008, PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Reserpine results in increased expression of NR3C1 mRNA CTD PMID:7984052 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nts neurotensin increases expression EXP Reserpine results in increased expression of NTS mRNA CTD PMID:1850078 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression
multiple interactions
EXP
ISO
Reserpine results in decreased expression of ODC1 protein
Reserpine inhibits the reaction [CB 3717 results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [CB 3717 results in increased expression of ODC1 mRNA]; Reserpine inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA]
CTD PMID:6519379, PMID:9194572, PMID:10354516, PMID:17371283 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase increases expression EXP Reserpine results in increased expression of PAM mRNA CTD PMID:8189248 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression EXP Reserpine results in increased expression of PCSK2 mRNA CTD PMID:8189248 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Penk proenkephalin multiple interactions
increases expression
decreases expression
EXP Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA]
Reserpine results in increased expression of PENK mRNA; Reserpine results in increased expression of PENK protein
Reserpine results in decreased expression of PENK mRNA
CTD PMID:1331675, PMID:1850078, PMID:3188958, PMID:3838946, PMID:4078631, PMID:7494455, PMID:17719177 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase multiple interactions
increases expression
decreases expression
EXP Chlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Dexamethasone inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Reserpine results in increased expression of and results in increased activity of PNMT protein
Reserpine results in increased expression of PNMT mRNA
CTD PMID:1359376, PMID:1687976, PMID:1714554, PMID:2903502, PMID:8063705, PMID:8479280, PMID:20504635 NCBI chr10:86,340,893...86,342,501
Ensembl chr10:86,340,940...86,342,858
JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
EXP Reserpine results in increased expression of POMC mRNA; Reserpine results in increased expression of POMC protein alternative form
POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]
CTD PMID:8479280, PMID:20504635 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression ISO Reserpine results in decreased expression of PRKACA protein CTD PMID:26114099 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prl prolactin increases expression EXP Reserpine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prss1 serine protease 1 decreases expression
increases expression
EXP Reserpine results in decreased expression of PRSS1 protein
Reserpine results in increased expression of PRSS1 protein
CTD PMID:8625754 NCBI chr 4:70,776,046...70,779,249
Ensembl chr 4:70,776,046...70,779,249
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Reserpine results in increased expression of PTGS2 protein CTD PMID:16081063 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase increases expression EXP Reserpine results in increased expression of PTS mRNA CTD PMID:7545485 NCBI chr 8:54,954,261...54,961,271
Ensembl chr 8:54,954,226...54,961,265
JBrowse link
G Rasd2 RASD family, member 2 decreases expression EXP Reserpine results in decreased expression of RASD2 mRNA CTD PMID:16352400 NCBI chr19:14,653,198...14,663,914
Ensembl chr19:14,653,198...14,663,914
JBrowse link
G Rgs10 regulator of G-protein signaling 10 decreases expression EXP Reserpine results in decreased expression of RGS10 mRNA CTD PMID:14505795 NCBI chr 1:199,782,076...199,823,440
Ensembl chr 1:199,782,078...199,823,386
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Reserpine results in decreased expression of RGS2 mRNA CTD PMID:14505795 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression EXP Reserpine results in decreased expression of RGS4 mRNA CTD PMID:14505795 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression EXP Reserpine results in decreased expression of RGS5 mRNA CTD PMID:14505795 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression EXP Reserpine results in decreased expression of RGS8 mRNA CTD PMID:14505795 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075
JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance
decreases expression
ISO
EXP
RGS9 affects the susceptibility to Reserpine
Reserpine results in decreased expression of RGS9 mRNA
CTD PMID:14505795, PMID:15728856 NCBI chr10:97,509,971...97,582,188
Ensembl chr10:97,509,971...97,582,188
JBrowse link
G Scg2 secretogranin II increases expression EXP Reserpine results in increased expression of SCG2 mRNA CTD PMID:1907749, PMID:8189248, PMID:8361347 NCBI chr 9:85,237,460...85,243,024
Ensembl chr 9:85,237,458...85,243,001
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression ISO Reserpine results in increased expression of SIAH1 mRNA CTD PMID:19607803 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
JBrowse link
G Slc18a1 solute carrier family 18 member A1 decreases activity
multiple interactions
ISO Reserpine results in decreased activity of SLC18A1 protein
Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]
CTD PMID:8245983, PMID:21712771 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding
multiple interactions
decreases activity
increases expression
affects response to substance
decreases response to substance
ISO
EXP
Reserpine binds to SLC18A2 protein
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]
Reserpine results in decreased activity of SLC18A2 protein
SLC18A2 protein binds to Reserpine
Reserpine results in increased expression of SLC18A2 mRNA
SLC18A2 affects the susceptibility to Reserpine
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]
SLC18A2 gene SNP results in decreased susceptibility to Reserpine
CTD PMID:1438304, PMID:7912402, PMID:8189248, PMID:9038139, PMID:15475732, PMID:17664021, PMID:18287335, PMID:29908239 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression EXP Reserpine results in decreased expression of SLC6A2 mRNA CTD PMID:7478180, PMID:7616203 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases activity
affects response to substance
ISO Reserpine results in decreased activity of SLC6A3 protein
SLC6A3 gene mutant form affects the susceptibility to Reserpine
CTD PMID:17664021, PMID:19615345 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP Reserpine results in decreased expression of SLC6A4 mRNA CTD PMID:10027743 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Snca synuclein alpha affects response to substance ISO SNCA protein mutant form affects the susceptibility to Reserpine CTD PMID:18622040 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Reserpine results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Syt7 synaptotagmin 7 multiple interactions EXP [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr 1:226,435,816...226,498,008
Ensembl chr 1:226,435,979...226,493,377
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases expression
EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine] results in increased expression of TAC1 mRNA; Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:9751140, PMID:17719177 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Th tyrosine hydroxylase increases expression
increases activity
decreases expression
affects activity
increases stability
multiple interactions
ISO
EXP
Reserpine results in increased expression of TH mRNA
Reserpine results in increased activity of TH protein
Reserpine results in increased expression of TH mRNA; Reserpine results in increased expression of TH protein
Reserpine results in decreased expression of TH mRNA
Reserpine affects the activity of TH protein
Reserpine results in increased stability of TH mRNA
Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]; Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Reserpine promotes the reaction [CREM protein binds to TH promoter]; Reserpine results in increased expression of and results in increased activity of TH protein
CTD PMID:1350653, PMID:1359376, PMID:1676830, PMID:1687822, PMID:1687976, PMID:1698642, PMID:1705056, PMID:1714554, PMID:1717808, PMID:1970845, PMID:1976760, PMID:1978789, PMID:1981253, PMID:2568627, PMID:2862954, PMID:2863328, PMID:2872048, PMID:2881815, PMID:2882513, PMID:2883324, PMID:2903502, PMID:7478180, PMID:7532593, PMID:7545485, PMID:7616203, PMID:7911764, PMID:8369965, PMID:8666980, PMID:9210518, PMID:9691425, PMID:11161478, PMID:11438978, PMID:20504635 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression
EXP IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases activity
decreases activity
EXP Reserpine results in increased activity of TPH1 protein
Reserpine results in decreased activity of TPH1 protein
CTD PMID:8369965 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP Reserpine results in increased expression of VGF mRNA CTD PMID:8189248 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Vip vasoactive intestinal peptide increases expression EXP Reserpine results in increased expression of VIP mRNA CTD PMID:1850078 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
strychnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP Strychnine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions
ISO Strychnine binds to CHRM2 protein
Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD PMID:9495826, PMID:15647330 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP
ISO
Strychnine binds to CHRM3 protein CTD PMID:12435818, PMID:15647330 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9495826 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Strychnine results in increased expression of and results in increased degradation of CYP2B1 protein CTD PMID:7906730 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Strychnine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Strychnine results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions
decreases activity
ISO
EXP
Strychnine analog binds to and results in decreased activity of GLRA1 protein; Strychnine binds to and results in decreased activity of GLRA1 protein; Strychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]; Strychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]
Strychnine results in decreased activity of GLRA1 protein
Genistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]; Quercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]
CTD PMID:7752562, PMID:15081878, PMID:16687139, PMID:20719748 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Glra2 glycine receptor, alpha 2 decreases activity EXP Strychnine results in decreased activity of GLRA2 protein CTD PMID:7752562 NCBI chr  X:30,612,894...30,832,078
Ensembl chr  X:30,612,903...30,831,483
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Strychnine inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Strychnine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO Strychnine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Strychnine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
Syrosingopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO syrosingopine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
vincaleukoblastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 decreases response to substance
increases expression
ISO ABCA2 mRNA results in decreased susceptibility to Vinblastine
Vinblastine results in increased expression of ABCA2 mRNA
CTD PMID:16928819 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 decreases response to substance
increases expression
ISO ABCA3 mRNA results in decreased susceptibility to Vinblastine
Vinblastine results in increased expression of ABCA3 mRNA
CTD PMID:16928819 NCBI chr10:13,723,365...13,780,558
Ensembl chr10:13,723,405...13,779,963
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases uptake
decreases activity
multiple interactions
increases export
ISO ABCB11 protein results in decreased uptake of Vinblastine
Vinblastine results in decreased activity of ABCB11 protein
Vinblastine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ABCB11 protein results in increased export of Vinblastine
CTD PMID:10617675, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
increases secretion
increases activity
increases expression
affects binding
multiple interactions
affects uptake
increases transport
ISO
EXP
ABCB1 protein results in decreased susceptibility to Vinblastine
ABCB1A protein results in increased secretion of Vinblastine
Vinblastine results in increased activity of ABCB1 protein mutant form
Vinblastine results in increased expression of ABCB1 protein
Vinblastine binds to ABCB1 protein
[Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Vinblastine; [sodium arsenite results in increased expression of ABCB1 protein] which results in decreased susceptibility to Vinblastine; [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Amiodarone inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; cnidiadin inhibits the reaction [ABCB1 protein results in increased export of Vinblastine]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]
CTD PMID:1967174, PMID:8917702, PMID:9148857, PMID:11355955, PMID:11455017, PMID:12235267, PMID:12708479, PMID:12711602, PMID:15466210, PMID:15640379, PMID:15725475, PMID:15824923, PMID:16221533, PMID:17284363, PMID:20041327, PMID:23976943, PMID:26689174 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases secretion EXP ABCB1B protein results in increased secretion of Vinblastine CTD PMID:12235267 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance
decreases response to substance
ISO
EXP
ABCC1 protein affects the susceptibility to Vinblastine
ABCC1 protein results in decreased susceptibility to Vinblastine
CTD PMID:9334814, PMID:11455017, PMID:16156793 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
decreases response to substance
multiple interactions
ISO
EXP
ABCC2 protein affects the transport of Vinblastine
ABCC2 protein results in decreased susceptibility to Vinblastine
[isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]
CTD PMID:9525973, PMID:11455017, PMID:15849751, PMID:25844889 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Ablim1 actin-binding LIM protein 1 affects response to substance ISO ABLIM1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:277,853,877...278,043,096 JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 affects response to substance ISO ACAT2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acot13 acyl-CoA thioesterase 13 affects response to substance ISO ACOT13 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:42,241,141...42,253,611
Ensembl chr17:42,241,159...42,253,649
JBrowse link
G Acp1 acid phosphatase 1 affects response to substance ISO ACP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Add3 adducin 3 affects response to substance ISO ADD3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP Vinblastine results in decreased expression of AIF1 mRNA CTD PMID:20624997 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Ak1 adenylate kinase 1 decreases expression EXP Vinblastine results in decreased expression of AK1 mRNA CTD PMID:20624997 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Aox1 aldehyde oxidase 1 affects response to substance ISO AOX1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Apln apelin decreases expression EXP Vinblastine results in decreased expression of APLN mRNA CTD PMID:20624997 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Atp5me ATP synthase membrane subunit e affects response to substance ISO ATP5ME protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436
JBrowse link
G Atp5mf ATP synthase membrane subunit f affects response to substance ISO ATP5MF protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
JBrowse link
G Aurkb aurora kinase B affects response to substance ISO AURKB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Axl Axl receptor tyrosine kinase affects response to substance ISO AXL protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects response to substance ISO BIRC2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects response to substance ISO BIRC3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 decreases response to substance ISO BIRC7 protein results in decreased susceptibility to Vinblastine CTD PMID:17437058 NCBI chr 3:176,438,335...176,443,864
Ensembl chr 3:176,439,199...176,443,195
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase affects response to substance ISO BUB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
EXP
ISO
Vinblastine results in increased cleavage of CASP3 protein
CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]
CTD PMID:16545138, PMID:20624997 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Vinblastine results in increased expression of CCL2 mRNA CTD PMID:20624997 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn2 cellular communication network factor 2 affects response to substance ISO CCN2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnb1 cyclin B1 affects response to substance
increases response to substance
ISO CCNB1 protein affects the susceptibility to Vinblastine
CCNB1 protein results in increased susceptibility to Vinblastine
CTD PMID:16217747, PMID:16849574 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 affects response to substance ISO CCNB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cd14 CD14 molecule increases expression EXP Vinblastine results in increased expression of CD14 mRNA CTD PMID:20624997 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd40lg CD40 ligand decreases response to substance
multiple interactions
ISO CD40LG protein results in decreased susceptibility to Vinblastine
CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
CTD PMID:16545138 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP Vinblastine results in increased expression of CD44 mRNA CTD PMID:20624997 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdca8 cell division cycle associated 8 affects response to substance ISO CDCA8 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects response to substance ISO CDK1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects response to substance ISO CDK2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Vinblastine results in increased expression of CDKN1A mRNA CTD PMID:20624997 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects response to substance ISO CDKN2C protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Vinblastine results in decreased expression of CDKN3 mRNA CTD PMID:20624997 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cenpa centromere protein A affects response to substance ISO CENPA protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Ckap2 cytoskeleton associated protein 2 affects response to substance ISO CKAP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 affects response to substance ISO COX17 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A affects response to substance ISO COX5A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 affects response to substance ISO COX6B1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859
JBrowse link
G Cp ceruloplasmin increases expression EXP Vinblastine results in increased expression of CP mRNA CTD PMID:20624997 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 affects response to substance ISO CREG1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
JBrowse link
G Cript CXXC repeat containing interactor of PDZ3 domain affects response to substance ISO CRIPT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:10,594,147...10,602,103
Ensembl chr 6:10,594,122...10,602,085
JBrowse link
G Ctss cathepsin S increases expression EXP Vinblastine results in increased expression of CTSS mRNA CTD PMID:20624997 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Vinblastine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:11602686 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcps decapping enzyme, scavenger affects response to substance ISO DCPS protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:36,321,992...36,374,665
Ensembl chr 8:36,321,993...36,374,673
JBrowse link
G Ddx23 DEAD-box helicase 23 affects response to substance ISO DDX23 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:140,325,453...140,342,730
Ensembl chr 7:140,325,431...140,342,727
JBrowse link
G Dera deoxyribose-phosphate aldolase affects response to substance ISO DERA protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:171,748,254...171,826,414
Ensembl chr 4:171,748,273...171,826,409
JBrowse link
G Dffb DNA fragmentation factor subunit beta affects response to substance ISO DFFB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dipk1a divergent protein kinase domain 1A affects response to substance ISO DIPK1A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:2,789,699...2,860,354
Ensembl chr14:2,789,650...2,860,333
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 affects response to substance ISO DKK1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 affects response to substance ISO DKK3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Donson DNA replication fork stabilization factor DONSON affects response to substance ISO DONSON protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:31,834,608...31,847,751
Ensembl chr11:31,837,839...31,847,490
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 affects response to substance ISO DSCC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:94,759,076...94,774,787
Ensembl chr 7:94,758,800...94,774,569
JBrowse link
G E2f1 E2F transcription factor 1 increases response to substance ISO E2F1 protein results in increased susceptibility to Vinblastine CTD PMID:16849574 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Vinblastine results in increased expression of EDNRB mRNA CTD PMID:20624997 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Efcab7 EF-hand calcium binding domain 7 affects response to substance ISO EFCAB7 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:118,673,835...118,724,581
Ensembl chr 5:118,541,979...118,724,581
JBrowse link
G Emp2 epithelial membrane protein 2 affects response to substance ISO EMP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:5,433,248...5,467,840
Ensembl chr10:5,433,248...5,467,839
JBrowse link
G Epcam epithelial cell adhesion molecule affects response to substance ISO EPCAM protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression EXP Vinblastine results in increased expression of EPRS mRNA CTD PMID:20624997 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance ISO ERBB2 protein affects the susceptibility to Vinblastine CTD PMID:10327070 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ereg epiregulin affects response to substance ISO EREG protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esm1 endothelial cell-specific molecule 1 decreases expression EXP Vinblastine results in decreased expression of ESM1 mRNA CTD PMID:20624997 NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131
JBrowse link
G Etfb electron transfer flavoprotein subunit beta affects response to substance ISO ETFB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Exosc9 exosome component 9 affects response to substance ISO EXOSC9 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:123,264,679...123,275,623
Ensembl chr 2:123,264,694...123,294,880
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Vinblastine results in increased expression of F3 mRNA CTD PMID:20624997 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C affects response to substance ISO FAM3C protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:49,388,962...49,439,892
Ensembl chr 4:49,387,989...49,439,867
JBrowse link
G Fancl FA complementation group L affects response to substance ISO FANCL protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:110,675,306...110,740,880
Ensembl chr14:110,676,090...110,740,317
JBrowse link
G Faslg Fas ligand increases expression ISO Vinblastine results in increased expression of FASLG protein CTD PMID:11716366 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression EXP Vinblastine results in increased expression of FCGR2B mRNA CTD PMID:20624997 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fen1 flap structure-specific endonuclease 1 affects response to substance ISO FEN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A affects response to substance ISO FKBP1A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fli1 Fli-1 proto-oncogene, ETS transcription factor affects response to substance ISO FLI1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:33,541,932...33,661,111
Ensembl chr 8:33,543,258...33,661,049
JBrowse link
G Fn1 fibronectin 1 affects response to substance ISO FN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit affects response to substance ISO FOSL1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G G0s2 G0/G1switch 2 affects response to substance ISO G0S2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Vinblastine results in increased expression of GADD45A mRNA CTD PMID:20624997 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression EXP Vinblastine results in increased expression of GADD45B mRNA CTD PMID:20624997 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Vinblastine results in increased expression of GADD45G mRNA CTD PMID:20624997 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gas7 growth arrest specific 7 decreases expression EXP Vinblastine results in decreased expression of GAS7 mRNA CTD PMID:20624997 NCBI chr10:54,010,723...54,240,805
Ensembl chr10:54,126,486...54,236,476
JBrowse link
G Ggct gamma-glutamyl cyclotransferase affects response to substance ISO GGCT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:85,186,644...85,192,857
Ensembl chr 4:85,186,644...85,192,834
JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance ISO GGCX protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:100,277,345...100,293,097
Ensembl chr 4:100,277,391...100,293,250
JBrowse link
G Gmnn geminin, DNA replication inhibitor affects response to substance ISO GMNN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:42,302,523...42,310,783
Ensembl chr17:42,302,540...42,310,783
JBrowse link
G Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta affects response to substance ISO GNPTAB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:28,956,363...29,023,232
Ensembl chr 7:28,956,512...29,022,868
JBrowse link
G Gpr176 G protein-coupled receptor 176 affects response to substance ISO GPR176 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:110,042,853...110,140,756
Ensembl chr 3:110,042,853...110,140,756
JBrowse link
G Gpsm2 G-protein signaling modulator 2 affects response to substance ISO GPSM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:211,480,120...211,528,096
Ensembl chr 2:211,480,400...211,527,919
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases response to substance EXP GSTP1 protein results in decreased susceptibility to Vinblastine CTD PMID:11455017 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gtf2i general transcription factor II I affects response to substance ISO GTF2I protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:25,410,804...25,487,970
Ensembl chr12:25,411,207...25,488,156
JBrowse link
G Gtf3a general transcription factor III A affects response to substance ISO GTF3A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:9,856,841...9,864,791
Ensembl chr12:9,856,842...9,864,791
JBrowse link
G Gtse1 G-2 and S-phase expressed 1 affects response to substance ISO GTSE1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220
JBrowse link
G Gusb glucuronidase, beta affects response to substance ISO GUSB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G H1f2 H1.2 linker histone, cluster member affects response to substance ISO H1-2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase affects response to substance ISO HADH protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 affects response to substance ISO HCLS1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:66,736,966...66,759,402
Ensembl chr11:66,736,966...66,759,402
JBrowse link
G Hmgb1 high mobility group box 1 affects response to substance ISO HMGB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgb2 high mobility group box 2 affects response to substance ISO HMGB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgn3 high mobility group nucleosomal binding domain 3 affects response to substance ISO HMGN3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:90,628,203...90,665,055
Ensembl chr 8:90,628,209...90,664,554
JBrowse link
G Hmmr hyaluronan-mediated motility receptor affects response to substance ISO HMMR protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Vinblastine results in increased expression of HMOX1 mRNA CTD PMID:20624997 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Homer1 homer scaffold protein 1 affects response to substance ISO HOMER1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
decreases expression
EXP
ISO
Vinblastine results in increased expression of ICAM1 mRNA
Vinblastine results in decreased expression of ICAM1 mRNA; Vinblastine results in decreased expression of ICAM1 protein
CTD PMID:12649748, PMID:20624997 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 affects response to substance ISO ID2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 affects response to substance ISO IDH2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:78,744,683...78,879,457
Ensembl chr 4:78,746,547...78,879,294
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
ISO Vinblastine results in increased phosphorylation of IKBKB protein
Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 affects response to substance ISO IL13RA2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061
JBrowse link
G Il1b interleukin 1 beta affects response to substance
increases expression
ISO
EXP
IL1B protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of IL1B mRNA
CTD PMID:16217747, PMID:20624997 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Vinblastine results in decreased chemical synthesis of IL6 protein
Vinblastine results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP Vinblastine results in decreased expression of INHA mRNA CTD PMID:20624997 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Inhba inhibin subunit beta A affects response to substance ISO INHBA protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Vinblastine results in decreased expression of ITGAL mRNA; Vinblastine results in decreased expression of ITGAL protein CTD PMID:12649748 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 affects response to substance ISO ITGB1BP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein] CTD PMID:12221076 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 affects response to substance ISO KANK1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:243,201,073...243,398,531
Ensembl chr 1:243,276,403...243,398,536
JBrowse link
G Kazn kazrin, periplakin interacting protein affects response to substance ISO KAZN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:160,637,235...161,730,513
Ensembl chr 5:160,639,578...160,742,479
JBrowse link
G Kif11 kinesin family member 11 affects response to substance ISO KIF11 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Kif15 kinesin family member 15 affects response to substance ISO KIF15 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
JBrowse link
G Kif1b kinesin family member 1B affects response to substance ISO KIF1B protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Kif20a kinesin family member 20A affects response to substance ISO KIF20A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Kif23 kinesin family member 23 affects response to substance ISO KIF23 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kif4a kinesin family member 4A affects response to substance ISO KIF4A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:70,461,700...70,561,084
Ensembl chr  X:70,461,718...70,561,189
JBrowse link
G Kpna2 karyopherin subunit alpha 2 affects response to substance ISO KPNA2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Lmnb1 lamin B1 affects response to substance ISO LMNB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 affects response to substance ISO LPAR1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Lrrc1 leucine rich repeat containing 1 affects response to substance ISO LRRC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:84,721,621...84,835,074
Ensembl chr 8:84,720,551...84,835,060
JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated affects response to substance ISO LSM7 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:11,724,932...11,732,020
Ensembl chr 7:11,724,962...11,727,388
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 affects response to substance ISO LTBP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:108,500,114...108,596,653
Ensembl chr 6:108,500,112...108,596,569
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 affects response to substance ISO MAD2L1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Vinblastine results in increased phosphorylation of MAPK8 protein
TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein]
CTD PMID:12221076 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein] CTD PMID:12221076 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 affects response to substance ISO MAPKAPK5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Melk maternal embryonic leucine zipper kinase affects response to substance ISO MELK protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356
JBrowse link
G Mme membrane metallo-endopeptidase affects response to substance ISO MME protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp1 matrix metallopeptidase 1 affects response to substance ISO MMP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mok MOK protein kinase affects response to substance ISO MOK protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:135,228,755...135,259,645
Ensembl chr 6:135,228,803...135,259,603
JBrowse link
G Mrpl57 mitochondrial ribosomal protein L57 affects response to substance ISO MRPL57 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:38,096,994...38,097,856
Ensembl chr15:38,095,803...38,097,835
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
increases expression
ISO
EXP
MYC protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of MYC mRNA
CTD PMID:18802399, PMID:20624997 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mycbp Myc binding protein affects response to substance ISO MYCBP protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:141,560,192...141,567,399
Ensembl chr 5:141,560,192...141,567,399
JBrowse link
G Nbn nibrin increases expression EXP Vinblastine results in increased expression of NBN mRNA CTD PMID:20624997 NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G affects response to substance ISO NCAPG protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:69,898,268...69,927,885
Ensembl chr14:69,899,128...69,927,938
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H affects response to substance ISO NCAPH protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Ndc80 NDC80 kinetochore complex component affects response to substance ISO NDC80 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 affects response to substance ISO NDUFA1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 affects response to substance ISO NDUFA13 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:21,275,311...21,282,246
Ensembl chr16:21,275,311...21,282,246
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 affects response to substance ISO NDUFA3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:64,172,462...64,175,174
Ensembl chr 1:64,172,540...64,175,099
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 affects response to substance ISO NDUFA7 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:18,683,553...18,696,332
Ensembl chr 7:18,683,553...18,696,330
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 affects response to substance ISO NDUFB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:67,378,188...67,385,267
Ensembl chr 4:67,378,188...67,385,266
JBrowse link
G Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 affects response to substance ISO NDUFC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:140,460,749...140,464,588
Ensembl chr 2:140,462,900...140,464,607
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 affects response to substance ISO NDUFC2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 affects response to substance ISO NDUFS6 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:26,471,173...26,471,587
Ensembl chr 2:26,471,173...26,471,584
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 affects response to substance ISO NDUFV2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 decreases localization ISO Vinblastine results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Vinblastine results in increased phosphorylation of NFKBIA protein
Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor decreases response to substance EXP Vinblastine results in decreased susceptibility to NGF protein CTD PMID:9524088 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Npy neuropeptide Y decreases expression EXP Vinblastine results in decreased expression of NPY mRNA CTD PMID:1671012 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Vinblastine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein] CTD PMID:20041327 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor affects response to substance ISO NSMAF protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 5:19,499,111...19,560,308
Ensembl chr 5:19,499,480...19,559,393
JBrowse link
G Nudt15 nudix hydrolase 15 affects response to substance ISO NUDT15 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:55,417,774...55,456,698
Ensembl chr15:55,419,502...55,456,698
JBrowse link
G Nudt4 nudix hydrolase 4 affects response to substance ISO NUDT4 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:36,643,916...36,660,334
Ensembl chr 7:36,643,916...36,660,141
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 affects response to substance ISO NUSAP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 affects response to substance ISO OAZ1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:11,752,127...11,754,587
Ensembl chr 7:11,752,412...11,754,508
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Vinblastine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:9270009 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Oip5 Opa interacting protein 5 affects response to substance ISO OIP5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 3:111,413,662...111,422,320
Ensembl chr 3:111,416,536...111,422,203
JBrowse link
G Olr1087 olfactory receptor 1087 affects response to substance ISO OR1I1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:13,996,966...13,997,907
Ensembl chr 7:13,996,966...13,997,907
JBrowse link
G Orc6 origin recognition complex, subunit 6 affects response to substance ISO ORC6 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr19:27,457,541...27,464,804
Ensembl chr19:27,457,474...27,464,805
JBrowse link
G Osbpl10 oxysterol binding protein-like 10 affects response to substance ISO OSBPL10 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:123,029,722...123,303,553
Ensembl chr 8:123,126,667...123,293,562
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein] CTD PMID:16545138 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta affects response to substance ISO PDHB protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor affects response to substance ISO PELO protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:47,266,758...47,268,526
Ensembl chr 2:47,266,738...47,268,625
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 affects response to substance ISO PGRMC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Pir pirin affects response to substance ISO PIR protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plagl1 PLAG1 like zinc finger 1 increases expression EXP Vinblastine results in increased expression of PLAGL1 mRNA CTD PMID:20624997 NCBI chr 1:7,219,587...7,270,169
Ensembl chr 1:7,252,349...7,259,035
JBrowse link
G Plat plasminogen activator, tissue type increases expression EXP Vinblastine results in increased expression of PLAT mRNA CTD PMID:20624997 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase affects response to substance ISO PLAU protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Vinblastine results in increased expression of PLAUR mRNA CTD PMID:20624997 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Vinblastine results in increased expression of PPP1R15A mRNA CTD PMID:20624997 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prc1 protein regulator of cytokinesis 1 affects response to substance ISO PRC1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Vinblastine affects the localization of PRKCD protein CTD PMID:9852137 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 affects response to substance ISO PSMB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:57,470,878...57,491,359
Ensembl chr 1:57,470,632...57,489,727
JBrowse link
G Psme4 proteasome activator subunit 4 affects response to substance ISO PSME4 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptges3 prostaglandin E synthase 3 affects response to substance ISO PTGES3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin affects response to substance ISO PTTG1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Ptx3 pentraxin 3 affects response to substance ISO PTX3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Qrich1 glutamine-rich 1 increases phosphorylation ISO Vinblastine results in increased phosphorylation of QRICH1 protein CTD PMID:17510977 NCBI chr 8:117,305,803...117,346,738
Ensembl chr 8:117,307,339...117,346,736
JBrowse link
G Rab11fip1 RAB11 family interacting protein 1 affects response to substance ISO RAB11FIP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:69,048,739...69,079,332
Ensembl chr16:69,046,514...69,079,332
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 affects response to substance ISO RACGAP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Ranbp1 RAN binding protein 1 affects response to substance ISO RANBP1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rassf1 Ras association domain family member 1 increases expression EXP Vinblastine results in increased expression of RASSF1 mRNA CTD PMID:20624997 NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit affects response to substance ISO REV3L protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr20:44,803,664...44,961,362
Ensembl chr20:44,803,666...44,961,382
JBrowse link
G Rfc5 replication factor C subunit 5 affects response to substance ISO RFC5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324
JBrowse link
G RGD1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2 affects response to substance ISO C5ORF15 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:37,757,131...37,769,781
Ensembl chr10:37,757,146...37,769,776
JBrowse link
G Rpa3 replication protein A3 affects response to substance ISO RPA3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 affects response to substance ISO RRM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Vinblastine results in increased expression of S100A8 mRNA CTD PMID:20624997 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Vinblastine results in increased expression of S100A9 mRNA CTD PMID:20624997 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sele selectin E increases expression EXP Vinblastine results in increased expression of SELE mRNA CTD PMID:20624997 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinb2 serpin family B member 2 affects response to substance ISO SERPINB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpine1 serpin family E member 1 increases expression
affects response to substance
EXP
ISO
Vinblastine results in increased expression of SERPINE1 mRNA
SERPINE1 protein affects the susceptibility to Vinblastine
CTD PMID:16217747, PMID:20624997 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sfxn1 sideroflexin 1 affects response to substance ISO SFXN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr17:11,046,588...11,082,219
Ensembl chr17:11,045,761...11,082,047
JBrowse link
G Shtn1 shootin 1 affects response to substance ISO SHTN1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:280,129,228...280,233,873
Ensembl chr 1:280,130,504...280,233,929
JBrowse link
G Skp2 S-phase kinase associated protein 2 affects response to substance ISO SKP2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Slc22a3 solute carrier family 22 member 3 affects response to substance ISO SLC22A3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Snrnp25 small nuclear ribonucleoprotein U11/U12 subunit 25 affects response to substance ISO SNRNP25 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:15,685,999...15,689,338
Ensembl chr10:15,686,008...15,689,325
JBrowse link
G Snx10 sorting nexin 10 affects response to substance ISO SNX10 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:81,311,490...81,375,248
Ensembl chr 4:81,311,490...81,374,158
JBrowse link
G Sod1 superoxide dismutase 1 affects response to substance ISO SOD1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Cycloheximide promotes the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA] CTD PMID:9852137 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sort1 sortilin 1 affects response to substance ISO SORT1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Spon1 spondin 1 increases expression EXP Vinblastine results in increased expression of SPON1 mRNA CTD PMID:20624997 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 affects response to substance ISO SRD5A1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Srgn serglycin affects response to substance ISO SRGN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr20:32,120,317...32,158,071
Ensembl chr20:32,120,320...32,139,789
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Vinblastine deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Vinblastine deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stc2 stanniocalcin 2 affects response to substance ISO STC2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Stk26 serine/threonine kinase 26 affects response to substance ISO STK26 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr  X:138,032,356...138,096,632
Ensembl chr  X:138,046,494...138,096,669
JBrowse link
G Strn striatin affects response to substance ISO STRN protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:1,232,729...1,319,603
Ensembl chr 6:1,237,758...1,319,541
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta affects response to substance ISO SUCLA2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:55,461,695...55,516,954
Ensembl chr15:55,461,695...55,516,952
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha affects response to substance ISO SUCLG1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 4:101,181,315...101,210,692
Ensembl chr 4:101,180,404...101,210,746
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects response to substance ISO SULT1A1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Syde1 synapse defective Rho GTPase homolog 1 affects response to substance ISO SYDE1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:14,037,646...14,043,632
Ensembl chr 7:14,037,620...14,043,779
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 affects response to substance ISO TBC1D4 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
G Tdg thymine-DNA glycosylase affects response to substance ISO TDG protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:27,194,000...27,213,676
Ensembl chr 7:27,193,998...27,214,236
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 affects response to substance
increases expression
ISO
EXP
TFPI2 protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of TFPI2 mRNA
CTD PMID:16217747, PMID:20624997 NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
JBrowse link
G Thbd thrombomodulin increases expression EXP Vinblastine results in increased expression of THBD mRNA CTD PMID:20624997 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Vinblastine results in increased expression of THBS1 mRNA CTD PMID:20624997 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Vinblastine results in increased expression of TIMP1 mRNA CTD PMID:20624997 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmem134 transmembrane protein 134 affects response to substance ISO TMEM134 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:219,374,005...219,383,365
Ensembl chr 1:219,374,060...219,379,557
JBrowse link
G Tmem14a transmembrane protein 14A affects response to substance ISO TMEM14A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 9:27,333,956...27,345,612
NCBI chr 9:27,334,103...27,351,302
Ensembl chr 9:27,343,853...27,345,070
Ensembl chr 9:27,343,853...27,345,070
JBrowse link
G Tmem156 transmembrane protein 156 affects response to substance ISO TMEM156 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:44,888,902...44,918,377
Ensembl chr14:44,889,287...44,918,373
JBrowse link
G Tmem97 transmembrane protein 97 affects response to substance ISO TMEM97 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538
JBrowse link
G Tmpo thymopoietin affects response to substance ISO TMPO protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Top2a DNA topoisomerase II alpha affects response to substance ISO TOP2A protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein] CTD PMID:12221076 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpd52l1 TPD52 like 1 increases expression
affects response to substance
EXP
ISO
Vinblastine results in increased expression of TPD52L1 mRNA
TPD52L1 protein affects the susceptibility to Vinblastine
CTD PMID:16217747, PMID:20624997 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Trim2 tripartite motif-containing 2 affects response to substance ISO TRIM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:183,145,096...183,223,819
Ensembl chr 2:183,145,089...183,213,228
JBrowse link
G Trmt5 tRNA methyltransferase 5 affects response to substance ISO TRMT5 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:96,164,579...96,171,680
Ensembl chr 6:96,153,014...96,171,779
JBrowse link
G Tspan13 tetraspanin 13 affects response to substance ISO TSPAN13 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:55,497,659...55,524,415
Ensembl chr 6:55,497,658...55,524,436
JBrowse link
G Ttf2 transcription termination factor 2 affects response to substance ISO TTF2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 2:203,317,673...203,350,752
Ensembl chr 2:203,318,855...203,350,736
JBrowse link
G Ttk Ttk protein kinase affects response to substance ISO TTK protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression EXP Vinblastine results in decreased expression of TUBA1B mRNA CTD PMID:20624997 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression EXP Vinblastine results in decreased expression of TUBA4A mRNA CTD PMID:20624997 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression EXP Vinblastine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Vinblastine results in decreased expression of TUBB5 mRNA CTD PMID:20624997 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tubg1 tubulin, gamma 1 decreases expression EXP Vinblastine results in decreased expression of TUBG1 mRNA CTD PMID:20624997 NCBI chr10:89,030,865...89,037,455
Ensembl chr10:89,030,865...89,037,455
JBrowse link
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X affects response to substance ISO UQCR10 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr14:84,935,480...84,937,741
Ensembl chr14:84,935,486...84,937,725
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Vinblastine results in increased expression of VCAM1 mRNA CTD PMID:20624997 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Vinblastine results in decreased expression of VEGFA mRNA CTD PMID:20624997 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfc vascular endothelial growth factor C affects response to substance ISO VEGFC protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vwf von Willebrand factor increases expression EXP Vinblastine results in increased expression of VWF mRNA CTD PMID:20624997 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Wdr61 WD repeat domain 61 affects response to substance ISO WDR61 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 8:59,296,339...59,313,663
Ensembl chr 8:59,296,346...59,313,574
JBrowse link
G Wsb2 WD repeat and SOCS box-containing 2 affects response to substance ISO WSB2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr12:44,941,655...44,962,679
Ensembl chr12:44,942,443...44,962,656
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta affects response to substance ISO YWHAQ protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:43,463,294...43,493,816
Ensembl chr 6:43,463,294...43,493,816
JBrowse link
G Zdhhc11 zinc finger, DHHC-type containing 11 affects response to substance ISO ZDHHC11 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 1:31,906,049...31,936,603
Ensembl chr 1:31,906,064...31,936,537
JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 affects response to substance ISO ZFP36L2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr 6:7,417,416...7,423,447
Ensembl chr 6:7,417,425...7,421,456
JBrowse link
G Zwint ZW10 interacting kinetochore protein affects response to substance ISO ZWINT protein affects the susceptibility to Vinblastine CTD PMID:16217747 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766
JBrowse link
vincamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Vincamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aamdc adipogenesis associated, Mth938 domain containing increases expression ISO Vincristine results in increased expression of AAMDC mRNA CTD PMID:23649840 NCBI chr 1:162,519,513...162,549,211
Ensembl chr 1:162,519,521...162,533,893
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA1 mRNA CTD PMID:19944135 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abca12 ATP binding cassette subfamily A member 12 increases expression
multiple interactions
ISO Vincristine results in increased expression of ABCA12 mRNA
[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA12 mRNA
CTD PMID:19944135, PMID:23649840 NCBI chr 9:78,521,477...78,693,421
Ensembl chr 9:78,522,464...78,693,028
JBrowse link
G Abca4 ATP binding cassette subfamily A member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA4 mRNA CTD PMID:19944135 NCBI chr 2:225,645,539...225,783,288
Ensembl chr 2:225,645,568...225,783,287
JBrowse link
G Abca5 ATP binding cassette subfamily A member 5 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA5 mRNA CTD PMID:19944135 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA8 mRNA CTD PMID:19944135 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases expression
multiple interactions
increases transport
decreases uptake
decreases response to substance
affects uptake
ISO
EXP
ABCB1 protein affects the susceptibility to Vincristine
Vincristine results in increased expression of ABCB1A mRNA
Vincristine results in increased expression of ABCB1 protein
[Estradiol results in decreased expression of ABCB1 protein] which results in increased uptake of and results in increased susceptibility to Vincristine; [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Vincristine; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB1 mRNA; [Vincristine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Fenofibrate inhibits the reaction [ABCB1 protein results in increased transport of Vincristine]; Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; NR1I2 protein promotes the reaction [Vincristine results in increased expression of ABCB1 protein]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; zosuquidar trihydrochloride inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased uptake of Vincristine
ABCB1 protein affects the uptake of Vincristine
CTD PMID:7905786, PMID:10617675, PMID:11792417, PMID:11934808, PMID:15239124, PMID:15645438, PMID:16038730, PMID:16221289, PMID:16316932, PMID:16925584, PMID:19944135, PMID:20041327, PMID:21344920, PMID:21833476, PMID:25058526 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects uptake EXP ABCB1B protein affects the uptake of Vincristine CTD PMID:11934808 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB4 mRNA CTD PMID:19944135 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB6 mRNA CTD PMID:19944135 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases response to substance
increases expression
multiple interactions
decreases response to substance
affects transport
affects response to substance
affects export
ISO
EXP
ABCC1 gene SNP results in increased susceptibility to Vincristine
Vincristine results in increased expression of ABCC1 mRNA
[Genistein results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
ABCC1 protein results in decreased susceptibility to Vincristine; ABCC1 results in decreased susceptibility to Vincristine
[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC1 mRNA; ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine; Buthionine Sulfoximine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Doxorubicin inhibits the reaction [ABCC1 protein affects the transport of Vincristine]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Quercetin promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; zafirlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]
ABCC1 protein affects the transport of Vincristine; ABCC1 protein mutant form affects the transport of Vincristine
ABCC1 protein affects the susceptibility to Vincristine
CTD PMID:7954421, PMID:8649356, PMID:8968083, PMID:10348353, PMID:10685512, PMID:10900222, PMID:11278867, PMID:11306701, PMID:11778547, PMID:12067707, PMID:12731862, PMID:12893836, PMID:15044619, PMID:15180633, PMID:15581632, PMID:15896345, PMID:16042792, PMID:16221289, PMID:19232821, PMID:19944135, PMID:20864405, PMID:21918036, PMID:22095822 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 multiple interactions
decreases response to substance
ISO 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine]; Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine] CTD PMID:19841739 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
decreases response to substance
ISO ABCC2 protein affects the export of Vincristine
[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC2 mRNA; ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine; myricetin inhibits the reaction [ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC2 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC2 protein results in decreased susceptibility to Vincristine]
CTD PMID:15896345, PMID:19944135, PMID:22095822 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC3 mRNA CTD PMID:19944135 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC4 mRNA CTD PMID:19944135 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCC5 mRNA CTD PMID:19944135 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC6 mRNA CTD PMID:19944135 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCD3 mRNA CTD PMID:19944135 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG1 mRNA CTD PMID:19944135 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCG2 mRNA CTD PMID:19944135, PMID:21833476 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 multiple interactions ISO [Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG4 mRNA CTD PMID:19944135 NCBI chr 8:48,604,915...48,626,219
Ensembl chr 8:48,606,403...48,619,592
JBrowse link
G Abhd11 abhydrolase domain containing 11 decreases expression ISO Vincristine results in decreased expression of ABHD11 mRNA CTD PMID:23649840 NCBI chr12:24,722,277...24,725,760
Ensembl chr12:24,722,283...24,724,997
JBrowse link
G Abtb2 ankyrin repeat and BTB domain containing 2 increases expression ISO Vincristine results in increased expression of ABTB2 mRNA CTD PMID:23649840 NCBI chr 3:93,494,706...93,648,750
Ensembl chr 3:93,495,106...93,647,721
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 decreases expression ISO Vincristine results in decreased expression of ACAD9 mRNA CTD PMID:23649840 NCBI chr 2:122,782,051...122,806,166
Ensembl chr 2:122,782,060...122,805,768
JBrowse link
G Ache acetylcholinesterase decreases expression
multiple interactions
EXP Vincristine results in decreased expression of ACHE protein
xaliproden inhibits the reaction [Vincristine results in decreased expression of ACHE protein]
CTD PMID:8413926 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO Vincristine results in increased expression of ACKR3 mRNA CTD PMID:23649840 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Actr2 actin related protein 2 increases expression ISO Vincristine results in increased expression of ACTR2 mRNA CTD PMID:23649840 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
JBrowse link
G Adat2 adenosine deaminase, tRNA-specific 2 decreases expression ISO Vincristine results in decreased expression of ADAT2 mRNA CTD PMID:23649840 NCBI chr 1:7,726,447...7,743,112
Ensembl chr 1:7,726,529...7,742,484
JBrowse link
G Adgrf4 adhesion G protein-coupled receptor F4 increases expression ISO Vincristine results in increased expression of ADGRF4 mRNA CTD PMID:23649840 NCBI chr 9:20,951,249...20,982,493
Ensembl chr 9:20,951,260...20,982,487
JBrowse link
G Adrb1 adrenoceptor beta 1 decreases expression ISO Vincristine results in decreased expression of ADRB1 mRNA CTD PMID:23649840 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 increases response to substance ISO ADRB2 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agbl3 ATP/GTP binding protein-like 3 decreases expression ISO Vincristine results in decreased expression of AGBL3 mRNA CTD PMID:23649840 NCBI chr 4:62,293,158...62,377,740
Ensembl chr 4:62,299,044...62,376,533
JBrowse link
G Ahsa2 activator of HSP90 ATPase homolog 2 decreases expression ISO Vincristine results in decreased expression of AHSA2P mRNA CTD PMID:23649840 NCBI chr14:108,262,795...108,274,000
Ensembl chr14:108,265,207...108,273,938
JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Vincristine results in increased expression of AIM2 mRNA CTD PMID:23649840 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Ak1 adenylate kinase 1 decreases expression EXP Vincristine results in decreased expression of AK1 mRNA CTD PMID:20624997 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Ak3 adenylate kinase 3 decreases expression ISO Vincristine results in decreased expression of AK3 mRNA CTD PMID:23649840 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Akap10 A-kinase anchoring protein 10 increases expression ISO Vincristine results in increased expression of AKAP10 mRNA CTD PMID:23649840 NCBI chr10:48,150,902...48,210,074
Ensembl chr10:48,150,902...48,210,074
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Vincristine inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]
Vincristine promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]
CTD PMID:16740780, PMID:18590705 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO Vincristine results in decreased expression of ALDOC mRNA CTD PMID:23649840 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases expression ISO Vincristine results in decreased expression of ALMS1 mRNA CTD PMID:23649840 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198
JBrowse link
G Alpk2 alpha-kinase 2 increases expression ISO Vincristine results in increased expression of ALPK2 mRNA CTD PMID:23649840 NCBI chr18:60,960,009...61,072,116
Ensembl chr18:60,960,662...61,057,365
JBrowse link
G Amh anti-Mullerian hormone decreases secretion ISO Vincristine results in decreased secretion of AMH protein CTD PMID:30657998 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 increases expression ISO Vincristine results in increased expression of ANAPC5 mRNA CTD PMID:23649840 NCBI chr12:39,209,134...39,242,696
Ensembl chr12:39,209,129...39,242,690
JBrowse link
G Ankdd1a ankyrin repeat and death domain containing 1A decreases expression ISO Vincristine results in decreased expression of ANKDD1A mRNA CTD PMID:23649840 NCBI chr 8:71,034,630...71,057,265
Ensembl chr 8:71,035,309...71,055,969
JBrowse link
G Ankhd1 ankyrin repeat and KH domain containing 1 increases expression ISO Vincristine results in increased expression of ANKHD1 mRNA CTD PMID:23649840 NCBI chr18:29,386,906...29,485,611
Ensembl chr18:29,386,809...29,492,718
JBrowse link
G Ankra2 ankyrin repeat family A member 2 increases expression ISO Vincristine results in increased expression of ANKRA2 mRNA CTD PMID:23649840 NCBI chr  X:82,407,601...82,418,229
Ensembl chr  X:82,407,598...82,418,425
JBrowse link
G Ankrd13c ankyrin repeat domain 13C decreases expression ISO Vincristine results in decreased expression of ANKRD13C mRNA CTD PMID:23649840 NCBI chr 2:264,785,379...264,833,283
Ensembl chr 2:264,786,242...264,833,283
JBrowse link
G Ankrd33b ankyrin repeat domain 33B increases expression ISO Vincristine results in increased expression of ANKRD33B mRNA CTD PMID:23649840 NCBI chr 2:84,361,061...84,436,912
Ensembl chr 2:84,361,061...84,437,084
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Vincristine results in decreased expression of ANKRD37 mRNA CTD PMID:23649840 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Anp32e acidic nuclear phosphoprotein 32 family member E decreases expression ISO Vincristine results in decreased expression of ANP32E mRNA CTD PMID:23649840 NCBI chr 2:198,040,573...198,057,005
Ensembl chr 2:198,040,536...198,057,003
JBrowse link
G Anxa1 annexin A1 increases expression ISO Vincristine results in increased expression of ANXA1 mRNA CTD PMID:23649840 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 increases expression ISO Vincristine results in increased expression of ANXA2 mRNA CTD PMID:23649840 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Ap1s2 adaptor related protein complex 1 subunit sigma 2 decreases expression ISO Vincristine results in decreased expression of AP1S2 mRNA CTD PMID:23649840 NCBI chr  X:32,329,883...32,376,301
Ensembl chr  X:32,329,598...32,355,307
JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 decreases expression ISO Vincristine results in decreased expression of APEX2 mRNA CTD PMID:23649840 NCBI chr  X:23,146,085...23,166,676
Ensembl chr  X:23,146,085...23,166,675
JBrowse link
G Apln apelin decreases expression EXP Vincristine results in decreased expression of APLN mRNA CTD PMID:20624997 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Apod apolipoprotein D increases expression ISO Vincristine results in increased expression of APOD mRNA CTD PMID:23649840 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Apold1 apolipoprotein L domain containing 1 increases expression ISO Vincristine results in increased expression of APOLD1 mRNA CTD PMID:23649840 NCBI chr 4:168,752,142...168,755,024
Ensembl chr 4:168,752,133...168,755,023
JBrowse link
G Aqp9 aquaporin 9 increases expression ISO Vincristine results in increased expression of AQP9 mRNA CTD PMID:23649840 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 decreases expression ISO Vincristine results in decreased expression of ARAP2 mRNA CTD PMID:23649840 NCBI chr14:48,726,033...48,922,809
Ensembl chr14:48,726,045...48,922,983
JBrowse link
G Arf1 ADP-ribosylation factor 1 increases expression ISO Vincristine results in increased expression of ARF1 mRNA CTD PMID:23649840 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arhgap15 Rho GTPase activating protein 15 increases expression ISO Vincristine results in increased expression of ARHGAP15 mRNA CTD PMID:23649840 NCBI chr 3:28,626,987...29,236,225
Ensembl chr 3:28,627,084...29,236,219
JBrowse link
G Arhgap18 Rho GTPase activating protein 18 decreases expression ISO Vincristine results in decreased expression of ARHGAP18 mRNA CTD PMID:23649840 NCBI chr 1:19,227,115...19,463,139
Ensembl chr 1:19,227,121...19,376,301
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression ISO Vincristine results in decreased expression of ARHGAP5 mRNA CTD PMID:23649840 NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880
JBrowse link
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 increases expression ISO Vincristine results in increased expression of ARHGEF6 mRNA CTD PMID:23649840 NCBI chr  X:159,722,031...159,841,344
Ensembl chr  X:159,723,866...159,841,072
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 increases expression ISO Vincristine results in increased expression of ARHGEF7 mRNA CTD PMID:23649840 NCBI chr16:83,006,732...83,117,065
Ensembl chr16:83,006,718...83,132,785
JBrowse link
G Arid2 AT-rich interaction domain 2 increases expression ISO Vincristine results in increased expression of ARID2 mRNA CTD PMID:23649840 NCBI chr 7:137,680,564...137,798,329
Ensembl chr 7:137,680,530...137,795,655
JBrowse link
G Arid4b AT-rich interaction domain 4B increases expression ISO Vincristine results in increased expression of ARID4B mRNA CTD PMID:23649840 NCBI chr17:53,831,353...53,955,897
Ensembl chr17:53,833,023...53,915,076
JBrowse link
G Arl5a ADP-ribosylation factor like GTPase 5A decreases expression ISO Vincristine results in decreased expression of ARL5A mRNA CTD PMID:23649840 NCBI chr 3:37,922,544...37,947,434
Ensembl chr 3:37,924,793...37,947,283
JBrowse link
G Arl5b ADP-ribosylation factor like GTPase 5B increases expression ISO Vincristine results in increased expression of ARL5B mRNA CTD PMID:23649840 NCBI chr17:82,065,893...82,092,693
Ensembl chr17:82,065,937...82,091,362
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 decreases expression ISO Vincristine results in decreased expression of ARL6IP1 mRNA CTD PMID:23649840 NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675
JBrowse link
G Armc8 armadillo repeat containing 8 decreases expression ISO Vincristine results in decreased expression of ARMC8 mRNA CTD PMID:23649840 NCBI chr 8:107,723,359...107,819,208
Ensembl chr 8:107,723,359...107,819,050
JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO Vincristine results in increased expression of ASPM mRNA CTD PMID:17374387 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 increases expression ISO Vincristine results in increased expression of ASXL1 mRNA CTD PMID:23649840 NCBI chr 3:148,832,231...148,902,356
Ensembl chr 3:148,837,814...148,900,452
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 decreases expression ISO Vincristine results in decreased expression of ATAD2 mRNA CTD PMID:23649840 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Vincristine results in increased expression of ATF3 mRNA CTD PMID:23649840 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Vincristine results in increased expression of ATF5 mRNA CTD PMID:23649840 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 increases expression ISO Vincristine results in increased expression of ATP2B4 mRNA CTD PMID:23649840 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma decreases expression ISO Vincristine results in decreased expression of ATP5F1C mRNA CTD PMID:23649840 NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Atp6v0e1 ATPase H+ transporting V0 subunit e1 increases expression ISO Vincristine results in increased expression of ATP6V0E1 mRNA CTD PMID:23649840 NCBI chr10:16,769,857...16,792,930
Ensembl chr10:16,769,666...16,792,909
JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to Vincristine CTD PMID:17510416 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 decreases expression ISO Vincristine results in decreased expression of ATP8A1 mRNA CTD PMID:23649840 NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311
JBrowse link
G Aurka aurora kinase A increases response to substance
increases expression
ISO AURKA gene SNP results in increased susceptibility to Vincristine
Vincristine results in increased expression of AURKA mRNA
CTD PMID:17374387, PMID:20864405 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Vincristine results in decreased expression of AURKB mRNA CTD PMID:23649840 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Avp arginine vasopressin increases expression ISO Vincristine results in increased expression of AVP protein CTD PMID:4356234 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G B3galt6 Beta-1,3-galactosyltransferase 6 decreases expression ISO Vincristine results in decreased expression of B3GALT6 mRNA CTD PMID:23649840 NCBI chr 5:173,423,475...173,425,611
Ensembl chr 5:173,423,475...173,425,611
JBrowse link
G B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 increases expression ISO Vincristine results in increased expression of B3GNT5 mRNA CTD PMID:23649840 NCBI chr11:84,919,055...84,931,160
Ensembl chr11:84,919,066...84,931,160
JBrowse link
G Bak1 BCL2-antagonist/killer 1 affects response to substance ISO BAK1 protein affects the susceptibility to Vincristine CTD PMID:22178383 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Vincristine results in increased expression of BAMBI mRNA CTD PMID:23649840 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO Vincristine results in decreased expression of BARD1 mRNA CTD PMID:23649840 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO Vincristine results in increased expression of BASP1 mRNA CTD PMID:23649840 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G Batf basic leucine zipper ATF-like transcription factor increases expression ISO Vincristine results in increased expression of BATF mRNA CTD PMID:23649840 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
affects response to substance
multiple interactions
ISO Vincristine results in decreased expression of BAX mRNA
BAX protein affects the susceptibility to Vincristine
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein; Vincristine results in increased cleavage of and results in increased expression of BAX protein
CTD PMID:9815696, PMID:15131059, PMID:16001973, PMID:22178383 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression ISO Vincristine results in increased expression of BCAT1 mRNA CTD PMID:23649840 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
increases phosphorylation
multiple interactions
ISO BCL2 protein results in decreased susceptibility to Vincristine
Vincristine results in increased phosphorylation of BCL2 protein
[Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [MIR497 results in decreased expression of BCL2 protein] which results in increased susceptibility to Vincristine; TYMP inhibits the reaction [Vincristine results in increased phosphorylation of BCL2 protein]
CTD PMID:9815696, PMID:15907805, PMID:20162574, PMID:21182165, PMID:21258880 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO Vincristine results in increased expression of BCL2A1 mRNA CTD PMID:23649840 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
affects response to substance
ISO Vincristine results in increased expression of BCL2L1 mRNA
BCL2L1 protein affects the susceptibility to Vincristine
CTD PMID:22178383, PMID:23649840 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO Vincristine results in decreased expression of BCLAF1 mRNA CTD PMID:23649840 NCBI chr 1:15,799,753...15,828,838
Ensembl chr 1:15,782,477...15,860,624
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO Vincristine results in increased expression of BCOR mRNA CTD PMID:23649840 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP [HOE 140, desArg(10)- binds to and results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Vincristine CTD PMID:17989505 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Vincristine CTD PMID:17989505 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Vincristine results in increased expression of BIRC2 mRNA CTD PMID:23649840 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Vincristine results in increased expression of BIRC3 mRNA CTD PMID:23649840 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO Vincristine results in decreased expression of BLM mRNA CTD PMID:23649840 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO Vincristine results in increased expression of BMP2 mRNA CTD PMID:23649840 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression
multiple interactions
ISO Vincristine results in decreased expression of BNIP3 mRNA
Vincristine affects the reaction [Valproic Acid affects the localization of BNIP3 protein]
CTD PMID:23649840, PMID:25446377 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO Vincristine results in decreased expression of BNIP3L mRNA CTD PMID:23649840 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Borcs7 BLOC-1 related complex subunit 7 increases expression ISO Vincristine results in increased expression of BORCS7 mRNA CTD PMID:23649840 NCBI chr 1:266,451,021...266,464,903
Ensembl chr 1:266,451,021...266,464,903
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 decreases expression ISO Vincristine results in decreased expression of BRIP1 mRNA CTD PMID:23649840 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Brwd1 bromodomain and WD repeat domain containing 1 decreases expression ISO Vincristine results in decreased expression of BRWD1 mRNA CTD PMID:23649840 NCBI chr11:36,338,080...36,430,473
Ensembl chr11:36,337,635...36,430,413
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Vincristine results in increased expression of BTG1 mRNA CTD PMID:23649840 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Vincristine results in increased expression of BTG2 mRNA CTD PMID:23649840 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btg4 BTG anti-proliferation factor 4 increases expression ISO Vincristine results in increased expression of BTG4 mRNA CTD PMID:23649840 NCBI chr 8:55,408,917...55,508,100
Ensembl chr 8:55,504,359...55,508,259
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein decreases expression ISO Vincristine results in decreased expression of BUB3 mRNA CTD PMID:23649840 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
JBrowse link
G C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 decreases expression ISO Vincristine results in decreased expression of C1GALT1 mRNA CTD PMID:23649840 NCBI chr 4:33,890,353...33,943,219
Ensembl chr 4:33,890,349...33,943,211
JBrowse link
G Cables2 Cdk5 and Abl enzyme substrate 2 decreases expression ISO Vincristine results in decreased expression of CABLES2 mRNA CTD PMID:23649840 NCBI chr 3:175,630,266...175,644,994
Ensembl chr 3:175,631,881...175,644,988
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 increases expression ISO Vincristine results in increased expression of CACNB2 mRNA CTD PMID:23649840 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682
JBrowse link
G Cald1 caldesmon 1 increases expression ISO Vincristine results in increased expression of CALD1 mRNA CTD PMID:23649840 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Vincristine results in decreased expression of CALM2 mRNA CTD PMID:23649840 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calu calumenin increases expression ISO Vincristine results in increased expression of CALU mRNA CTD PMID:23649840 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression ISO Vincristine results in decreased expression of CAMK2D mRNA CTD PMID:23649840 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 increases response to substance ISO CAMKK1 gene SNP results in increased susceptibility to Vincristine CTD PMID:21245421 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165
JBrowse link
G Capg capping actin protein, gelsolin like increases expression ISO Vincristine results in increased expression of CAPG mRNA CTD PMID:23649840 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression ISO Vincristine results in decreased expression of CARHSP1 mRNA CTD PMID:23649840 NCBI chr10:7,041,510...7,055,107
Ensembl chr10:7,041,510...7,055,101
JBrowse link
G Casp1 caspase 1 increases expression ISO Vincristine results in increased expression of CASP1 mRNA CTD PMID:23649840 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
EXP Vincristine results in increased cleavage of CASP3 protein
Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
Vincristine results in increased expression of CASP3 mRNA; Vincristine results in increased expression of CASP3 protein
CTD PMID:20624997, PMID:29958920 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases expression ISO Vincristine results in increased expression of CASP6 mRNA CTD PMID:16001973 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases expression
increases response to substance
multiple interactions
ISO Vincristine results in increased expression of CASP8 mRNA
CASP8 protein results in increased susceptibility to Vincristine
Vincristine results in increased expression of and results in increased cleavage of CASP8 protein
CTD PMID:16001973, PMID:22010212 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase affects response to substance
decreases expression
multiple interactions
ISO
EXP
CAT protein affects the susceptibility to Vincristine
Vincristine results in decreased expression of CAT protein
tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
CTD PMID:11178967, PMID:24201307, PMID:25537132, PMID:26102012 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbx3 chromobox 3 decreases expression ISO Vincristine results in decreased expression of CBX3 mRNA CTD PMID:23649840 NCBI chr 4:81,243,809...81,257,898
Ensembl chr 4:81,244,469...81,257,897
JBrowse link
G Cbx5 chromobox 5 decreases expression ISO Vincristine results in decreased expression of CBX5 mRNA CTD PMID:23649840 NCBI chr 7:144,819,673...144,865,014
Ensembl chr 7:144,819,420...144,837,583
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 decreases expression ISO Vincristine results in decreased expression of CCAR1 mRNA CTD PMID:23649840 NCBI chr20:32,373,443...32,416,044
Ensembl chr20:32,373,443...32,416,044
JBrowse link
G Ccdc12 coiled-coil domain containing 12 decreases expression ISO Vincristine results in decreased expression of CCDC12 mRNA CTD PMID:23649840 NCBI chr 8:118,925,682...118,977,038
Ensembl chr 8:118,926,478...118,977,051
JBrowse link
G Ccdc186 coiled-coil domain containing 186 decreases expression ISO Vincristine results in decreased expression of CCDC186 mRNA CTD PMID:23649840 NCBI chr 1:277,603,601...277,635,379
Ensembl chr 1:277,606,995...277,629,196
JBrowse link
G Ccdc198 coiled-coil domain containing 198 decreases expression ISO Vincristine results in decreased expression of CCDC198 mRNA CTD PMID:23649840 NCBI chr15:26,090,458...26,106,523 JBrowse link
G Ccdc32 coiled-coil domain containing 32 decreases expression ISO Vincristine results in decreased expression of CCDC32 mRNA CTD PMID:23649840 NCBI chr 3:110,816,327...110,828,824
Ensembl chr 3:110,816,337...110,828,879
JBrowse link
G Ccdc82 coiled-coil domain containing 82 increases expression ISO Vincristine results in increased expression of CCDC82 mRNA CTD PMID:23649840 NCBI chr 8:11,888,460...11,927,920
Ensembl chr 8:11,888,591...11,927,919
JBrowse link
G Cchcr1 coiled-coil alpha-helical rod protein 1 decreases expression ISO Vincristine results in decreased expression of CCHCR1 mRNA CTD PMID:23649840 NCBI chr20:3,730,968...3,745,721
Ensembl chr20:3,730,955...3,740,009
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Vincristine results in increased expression of CCL1 mRNA CTD PMID:23649840 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO
EXP
Vincristine results in increased expression of CCL2 mRNA CTD PMID:20624997, PMID:23649840 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Vincristine results in increased expression of CCL20 mRNA CTD PMID:23649840 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Vincristine results in increased expression of CCL22 mRNA CTD PMID:23649840 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Vincristine results in increased expression of CCL4 mRNA CTD PMID:23649840 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Vincristine results in increased expression of CCL5 mRNA CTD PMID:23649840 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 decreases response to substance ISO CCN2 mRNA results in decreased susceptibility to Vincristine CTD PMID:24154679 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnb1 cyclin B1 affects response to substance
increases expression
ISO CCNB1 protein affects the susceptibility to Vincristine
Vincristine results in increased expression of CCNB1 mRNA
CTD PMID:22178383, PMID:23649840 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Vincristine results in increased expression of CCNB2 mRNA CTD PMID:23649840 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Vincristine results in decreased expression of CCNE1 mRNA CTD PMID:23649840 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Vincristine results in decreased expression of CCNE2 mRNA CTD PMID:23649840 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnl1 cyclin L1 decreases expression ISO Vincristine results in decreased expression of CCNL1 mRNA CTD PMID:23649840 NCBI chr 2:157,747,295...157,759,838
Ensembl chr 2:157,747,542...157,759,838
JBrowse link
G Cd109 CD109 molecule increases expression ISO Vincristine results in increased expression of CD109 mRNA CTD PMID:23649840 NCBI chr 8:85,951,420...86,065,411
Ensembl chr 8:85,951,191...86,065,409
JBrowse link
G Cd14 CD14 molecule increases expression EXP Vincristine results in increased expression of CD14 mRNA CTD PMID:20624997 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd200 Cd200 molecule increases expression ISO Vincristine results in increased expression of CD200 mRNA CTD PMID:23649840 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196
JBrowse link
G Cd274 CD274 molecule increases expression ISO Vincristine results in increased expression of CD274 mRNA CTD PMID:23649840 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd36 CD36 molecule increases expression EXP Vincristine results in increased expression of CD36 mRNA CTD PMID:20624997 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40 CD40 molecule increases expression ISO Vincristine results in increased expression of CD40 mRNA CTD PMID:23649840 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Vincristine results in increased expression of CD44 mRNA CTD PMID:23649840 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd48 Cd48 molecule increases expression ISO Vincristine results in increased expression of CD48 mRNA CTD PMID:23649840 NCBI chr13:90,116,601...90,140,371
Ensembl chr13:90,116,843...90,140,371
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Vincristine results in increased expression of CD55 mRNA CTD PMID:23649840 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd69 Cd69 molecule increases expression ISO Vincristine results in increased expression of CD69 mRNA CTD PMID:23649840 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Vincristine results in increased expression of CD80 mRNA CTD PMID:23649840 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule increases expression ISO Vincristine results in increased expression of CD83 mRNA CTD PMID:23649840 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule increases expression ISO Vincristine results in increased expression of CD86 mRNA CTD PMID:23649840 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression ISO Vincristine results in increased expression of CDC42EP3 mRNA CTD PMID:23649840 NCBI chr 6:1,922,500...1,942,972
Ensembl chr 6:1,922,500...1,942,972
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression ISO Vincristine results in increased expression of CDC42EP4 mRNA CTD PMID:23649840 NCBI chr10:102,244,680...102,269,272
Ensembl chr10:102,244,681...102,269,272
JBrowse link
G Cdc42se1 CDC42 small effector 1 increases expression ISO Vincristine results in increased expression of CDC42SE1 mRNA CTD PMID:23649840 NCBI chr 2:196,402,837...196,410,664
Ensembl chr 2:196,402,837...196,410,659
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Vincristine results in decreased expression of CDC6 mRNA CTD PMID:23649840 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression ISO Vincristine results in decreased expression of CDCA3 mRNA CTD PMID:23649840 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdca7 cell division cycle associated 7 decreases expression ISO Vincristine results in decreased expression of CDCA7 mRNA CTD PMID:23649840 NCBI chr 3:59,153,281...59,163,916
Ensembl chr 3:59,153,280...59,163,913
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Vincristine results in increased expression of CDH1 mRNA CTD PMID:23649840 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Vincristine results in decreased expression of CDK1 mRNA CTD PMID:23649840 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk10 cyclin-dependent kinase 10 decreases expression ISO Vincristine results in decreased expression of CDK10 mRNA CTD PMID:23649840 NCBI chr19:56,024,903...56,032,610
Ensembl chr19:56,024,903...56,032,605
JBrowse link
G Cdk19 cyclin-dependent kinase 19 decreases expression ISO Vincristine results in decreased expression of CDK19 mRNA CTD PMID:23649840 NCBI chr20:45,458,499...45,598,799
Ensembl chr20:45,458,558...45,598,798
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Vincristine results in decreased expression of CDK2 mRNA CTD PMID:23649840 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
EXP
ISO
Vincristine results in increased expression of CDKN1A mRNA
resveratrol inhibits the reaction [Vincristine results in increased expression of CDKN1A mRNA]
CTD PMID:20624997, PMID:23649840, PMID:26055805 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases response to substance ISO CDKN2A protein results in increased susceptibility to Vincristine CTD PMID:16786135 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO Vincristine results in decreased expression of CDKN2C mRNA CTD PMID:23649840 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Vincristine results in increased expression of CEACAM1 mRNA CTD PMID:23649840 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Vincristine results in increased expression of CEBPB mRNA CTD PMID:16001973 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Celf1 CUGBP, Elav-like family member 1 decreases expression ISO Vincristine results in decreased expression of CELF1 mRNA CTD PMID:23649840 NCBI chr 3:79,768,900...79,844,548
Ensembl chr 3:79,823,945...79,842,082
JBrowse link
G Cenpc centromere protein C decreases expression ISO Vincristine results in decreased expression of CENPC1 mRNA CTD PMID:23649840