CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: arecoline
Accession: CHEBI:2814
browse the term
Definition: A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Synonyms: exact_synonym: methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
related_synonym: Formula=C8H13NO2; InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3; InChIKey=HJJPJSXJAXAIPN-UHFFFAOYSA-N; SMILES=COC(=O)C1=CCCN(C)C1; arecaidine methyl ester; arecaline; arecholine; arekolin; methylarecaiden; methylarecaidin
xref: CAS:63-75-2; DrugBank:DB04365; HMDB:HMDB0030353; KEGG:C10129; KNApSAcK:C00002020; LINCS:LSM-15214
xref_mesh: MESH:D001115
xref: PMID:21809341; PMID:22493525; PMID:23525646; PMID:23895157; Patent:CN101411705; Patent:CN102464607; Patent:US2506458; Reaxys:123045; Wikipedia:Arecoline
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Acta2
actin alpha 2, smooth muscle
multiple interactions increases expression
ISO
U 0126 inhibits the reaction [Arecoline results in increased expression of ACTA2 protein] Arecoline results in increased expression of ACTA2 mRNA; Arecoline results in increased expression of ACTA2 protein
CTD
PMID:32441858
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ahrr
aryl-hydrocarbon receptor repressor
multiple interactions
ISO
Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]
CTD
PMID:17234337
NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Akr1a1
aldo-keto reductase family 1 member A1
decreases expression
ISO
Arecoline results in decreased expression of AKR1A1 mRNA
CTD
PMID:17682004
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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Akt1
AKT serine/threonine kinase 1
multiple interactions affects phosphorylation
ISO EXP
[arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [AKT activator SC79 results in decreased phosphorylation of AKT1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein] Arecoline affects the phosphorylation of AKT1 protein
CTD
PMID:30910432 PMID:33929070
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldh9a1
aldehyde dehydrogenase 9 family, member A1
decreases expression
ISO
Arecoline results in decreased expression of ALDH9A1 mRNA
CTD
PMID:17682004
NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
decreases expression
ISO
Arecoline results in decreased expression of APEX1 mRNA
CTD
PMID:17682004
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Ar
androgen receptor
increases expression
EXP
Arecoline results in increased expression of AR mRNA; Arecoline results in increased expression of AR protein
CTD
PMID:21741983
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bak1
BCL2-antagonist/killer 1
increases expression
EXP
Arecoline results in increased expression of BAK1 protein
CTD
PMID:33929070
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO EXP
Arecoline results in decreased expression of BCL2 protein
CTD
PMID:22108589 PMID:33929070
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
increases expression
EXP
Arecoline results in increased expression of BCL2L1 protein
CTD
PMID:33929070
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bid
BH3 interacting domain death agonist
multiple interactions
EXP
Arecoline affects the expression of and results in increased cleavage of BID protein
CTD
PMID:33929070
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Brca1
BRCA1, DNA repair associated
decreases expression
ISO
Arecoline results in decreased expression of BRCA1 mRNA
CTD
PMID:17682004
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Casp3
caspase 3
increases activity increases cleavage
ISO EXP
Arecoline results in increased activity of CASP3 protein Arecoline results in increased cleavage of CASP3 protein
CTD
PMID:22108589 PMID:33929070
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases cleavage
EXP
Arecoline results in increased cleavage of CASP8 protein
CTD
PMID:33929070
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases cleavage
EXP
Arecoline results in increased cleavage of CASP9 protein
CTD
PMID:33929070
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases expression
EXP
Arecoline analog results in decreased expression of CAT
CTD
PMID:25056785
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl5
C-C motif chemokine ligand 5
increases secretion
ISO
Arecoline results in increased secretion of CCL5 protein
CTD
PMID:21297082
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccnd1
cyclin D1
increases expression multiple interactions
EXP ISO
Arecoline results in increased expression of CCND1 mRNA; Arecoline results in increased expression of CCND1 protein [arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [AKT activator SC79 results in decreased expression of CCND1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased expression of CCND1 protein
CTD
PMID:21741983 PMID:30910432
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnh
cyclin H
decreases expression
ISO
Arecoline results in decreased expression of CCNH mRNA
CTD
PMID:17682004
NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
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Cdc25c
cell division cycle 25C
multiple interactions decreases expression
ISO
[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein Arecoline results in decreased expression of CDC25C protein
CTD
PMID:22108589
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdh1
cadherin 1
multiple interactions decreases expression
ISO
U 0126 inhibits the reaction [Arecoline results in decreased expression of CDH1 protein]
CTD
PMID:32441858
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
increases expression
ISO
Arecoline results in increased expression of CDH2 protein
CTD
PMID:32441858
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdk1
cyclin-dependent kinase 1
decreases activity multiple interactions
ISO
Arecoline results in decreased activity of CDK1 protein [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
CTD
PMID:22108589
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk4
cyclin-dependent kinase 4
increases expression
EXP
Arecoline results in increased expression of CDK4 mRNA; Arecoline results in increased expression of CDK4 protein
CTD
PMID:21741983
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Chaf1a
chromatin assembly factor 1 subunit A
decreases expression
ISO
Arecoline results in decreased expression of CHAF1A mRNA
CTD
PMID:17682004
NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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Chaf1b
chromatin assembly factor 1 subunit B
decreases expression
ISO
Arecoline results in decreased expression of CHAF1B mRNA
CTD
PMID:17682004
NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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Chrm3
cholinergic receptor, muscarinic 3
affects binding multiple interactions
ISO
CHRM3 protein binds to Arecoline brucine promotes the reaction [Arecoline binds to CHRM3 protein]
CTD
PMID:9224827
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Col4a6
collagen type IV alpha 6 chain
increases expression
ISO
Arecoline results in increased expression of COL4A6 protein
CTD
PMID:32441858
NCBI chr X:104,766,463...105,117,499
Ensembl chr X:104,766,957...105,117,500
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Cryab
crystallin, alpha B
multiple interactions
ISO
[4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein
CTD
PMID:19840781
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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Ctnnb1
catenin beta 1
multiple interactions
ISO
[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of CTNNB1 protein
CTD
PMID:26464283
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD
PMID:17234337 PMID:17707585
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity
EXP
Arecoline analog results in increased activity of CYP1A2 protein
CTD
PMID:25056785
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
decreases expression
ISO
Arecoline results in decreased expression of CYP26B1 mRNA
CTD
PMID:17682004
NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases activity
EXP
Arecoline analog results in increased activity of CYP2E1 protein
CTD
PMID:25056785
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dclre1b
DNA cross-link repair 1B
decreases expression
ISO
Arecoline results in decreased expression of DCLRE1B mRNA
CTD
PMID:17682004
NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423
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Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
Arecoline results in increased expression of DDIT4 mRNA
CTD
PMID:17682004
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Ddr1
discoidin domain receptor tyrosine kinase 1
increases expression
ISO
arecoline increases expression of DDR1 mRNA and protein in human cancer cell line OKF4/hTERT
RGD
PMID:31253192
RGD:151347620
NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
increases expression
ISO
Arecoline results in increased expression of DNAJA1 mRNA
CTD
PMID:17682004
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
decreases expression
ISO
Arecoline results in decreased expression of EEF1E1 mRNA
CTD
PMID:17682004
NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of EGFR protein modified form; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein]
CTD
PMID:26464283
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of EIF4EBP1 protein
CTD
PMID:30910432
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
decreases expression
ISO
Arecoline results in decreased expression of ERCC2 mRNA
CTD
PMID:17682004
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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Fadd
Fas associated via death domain
increases expression
EXP
Arecoline results in increased expression of FADD protein
CTD
PMID:33929070
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fancg
FA complementation group G
decreases expression
ISO
Arecoline results in decreased expression of FANCG mRNA
CTD
PMID:17682004
NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
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Fas
Fas cell surface death receptor
increases expression
EXP
Arecoline results in increased expression of FAS protein
CTD
PMID:33929070
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
EXP
Arecoline results in increased expression of FASLG protein
CTD
PMID:33929070
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fat1
FAT atypical cadherin 1
increases expression
ISO
arecoline cotreated with dimethyl sulfoxide increases expression of Fat1 protein in tongue
RGD
PMID:30624777
RGD:151347668
NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107
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Fn1
fibronectin 1
increases expression
ISO
Arecoline results in increased expression of FN1 protein
CTD
PMID:26908192
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the expression of FOS protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of FOS protein
CTD
PMID:26464283
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fshb
follicle stimulating hormone subunit beta
increases expression
EXP
Arecoline results in increased expression of FSHB protein
CTD
PMID:21741983
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Gata4
GATA binding protein 4
increases expression
EXP
Arecoline results in increased expression of GATA4 protein
CTD
PMID:34999050
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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Gdf15
growth differentiation factor 15
increases expression
ISO
Arecoline results in increased expression of GDF15 mRNA
CTD
PMID:17682004
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gss
glutathione synthetase
decreases expression
ISO
Arecoline results in decreased expression of GSS mRNA
CTD
PMID:17682004
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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Gtf2h5
general transcription factor IIH subunit 5
decreases expression
ISO
Arecoline results in decreased expression of GTF2H5 mRNA
CTD
PMID:17682004
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
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Hes1
hes family bHLH transcription factor 1
increases expression
ISO
arecoline cotreated with dimethyl sulfoxide increases expression of Hes1 protein in tongue
RGD
PMID:30624777
RGD:151347668
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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Hspa14
heat shock protein family A (Hsp70) member 14
increases expression
ISO
Arecoline results in increased expression of HSPA14 mRNA
CTD
PMID:17682004
NCBI chr17:74,728,945...74,749,727
Ensembl chr17:74,728,899...74,749,727
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Hspb1
heat shock protein family B (small) member 1
multiple interactions
ISO
[4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein
CTD
PMID:19840781
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Il6
interleukin 6
decreases secretion increases expression decreases expression
ISO EXP
Arecoline results in decreased secretion of IL6 protein Arecoline results in increased expression of IL6 protein Arecoline results in decreased expression of IL6 mRNA
CTD
PMID:22108589 PMID:34999050
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ins1
insulin 1
multiple interactions
ISO
Arecoline inhibits the reaction [INS1 protein results in increased uptake of Glucose]
CTD
PMID:20406654
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Jak2
Janus kinase 2
increases phosphorylation
EXP
Arecoline results in increased phosphorylation of JAK2 protein
CTD
PMID:34999050
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Lcmt1
leucine carboxyl methyltransferase 1
decreases expression
ISO
Arecoline results in decreased expression of LCMT1 mRNA
CTD
PMID:17682004
NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
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Lhb
luteinizing hormone subunit beta
increases expression
EXP
Arecoline results in increased expression of LHB protein
CTD
PMID:21741983
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Maoa
monoamine oxidase A
decreases expression
ISO
Arecoline results in decreased expression of MAOA mRNA
CTD
PMID:17682004
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Map2k5
mitogen activated protein kinase kinase 5
increases expression
EXP
Arecoline results in increased expression of MAP2K5 protein
CTD
PMID:34999050
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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Mapk1
mitogen activated protein kinase 1
multiple interactions increases phosphorylation
ISO EXP
[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein] Arecoline results in increased phosphorylation of MAPK1 protein U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK1 protein]
CTD
PMID:26464283 PMID:32441858 PMID:34999050
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO EXP
[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein] Arecoline results in increased phosphorylation of MAPK3 protein U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK3 protein]
CTD
PMID:26464283 PMID:32441858 PMID:34999050
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk7
mitogen-activated protein kinase 7
increases phosphorylation
EXP
Arecoline results in increased phosphorylation of MAPK7 protein
CTD
PMID:34999050
NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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Mapk8
mitogen-activated protein kinase 8
increases phosphorylation
EXP
Arecoline results in increased phosphorylation of MAPK8 protein
CTD
PMID:34999050
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
increases phosphorylation
EXP
Arecoline results in increased phosphorylation of MAPK9 protein
CTD
PMID:34999050
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mir136
microRNA 136
increases expression
ISO
Arecoline results in increased expression of MIR136
CTD
PMID:21750350
NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177
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Mir143
microRNA 143
increases expression
ISO
Arecoline results in increased expression of MIR143
CTD
PMID:21750350
NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110
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Mir145
microRNA 145
increases expression
ISO
Arecoline results in increased expression of MIR145
CTD
PMID:21750350
NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
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Mir23a
microRNA 23a
increases expression
ISO
Arecoline results in increased expression of MIR23A
CTD
PMID:21750350
NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
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Mir26a
microRNA 26a
increases expression
ISO
Arecoline results in increased expression of MIR26A1
CTD
PMID:21750350
NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
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Mir26b
microRNA 26b
increases expression
ISO
Arecoline results in increased expression of MIR26B
CTD
PMID:21750350
NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
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Mir30a
microRNA 30a
increases expression
ISO
Arecoline results in increased expression of MIR30A
CTD
PMID:21750350
NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
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Mlh1
mutL homolog 1
decreases expression
ISO
Arecoline results in decreased expression of MLH1 mRNA
CTD
PMID:17682004
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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Mmp2
matrix metallopeptidase 2
decreases secretion increases expression
ISO EXP
Arecoline results in decreased secretion of MMP2 protein Arecoline results in increased expression of MMP2 protein
CTD
PMID:16311067 PMID:33929070
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
increases expression
EXP
Arecoline results in increased expression of MMP9 protein
CTD
PMID:33929070
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Msh2
mutS homolog 2
decreases expression
ISO
Arecoline results in decreased expression of MSH2 mRNA
CTD
PMID:17682004
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Mt1
metallothionein 1
increases expression multiple interactions
ISO
Arecoline results in increased expression of MT1A mRNA Benzo(a)pyrene promotes the reaction [Arecoline results in increased expression of MT1A mRNA]
CTD
PMID:17418620
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of MTOR protein
CTD
PMID:30910432
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Myog
myogenin
decreases expression
ISO
Arecoline results in decreased expression of MYOG protein
CTD
PMID:23933062
NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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Nat8
N-acetyltransferase 8
decreases expression
ISO
Arecoline results in decreased expression of NAT8 mRNA
CTD
PMID:17682004
NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763
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Nfatc3
nuclear factor of activated T-cells 3
increases expression
EXP
Arecoline results in increased expression of NFATC3 protein
CTD
PMID:34999050
NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
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Notch1
notch receptor 1
increases expression
ISO
arecoline cotreated with dimethyl sulfoxide increases expression of Notch1 protein in tongue
RGD
PMID:30624777
RGD:151347668
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Nppb
natriuretic peptide B
increases expression
EXP
Arecoline results in increased expression of NPPB protein
CTD
PMID:33929070 PMID:34999050
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Phlpp2
PH domain and leucine rich repeat protein phosphatase 2
multiple interactions
ISO
[arecoline hydrobromide results in increased abundance of Arecoline] which results in increased expression of PHLPP2 mRNA; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein]
CTD
PMID:30910432
NCBI chr19:37,835,125...37,901,804
Ensembl chr19:37,835,125...37,905,513
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
increases expression
EXP
Arecoline results in increased expression of PIK3R1 mRNA
CTD
PMID:20724125
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
increases expression
EXP
Arecoline results in increased expression of PPP3CA protein
CTD
PMID:34999050
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Prkdc
protein kinase, DNA-activated, catalytic subunit
decreases expression
ISO
Arecoline results in decreased expression of PRKDC mRNA
CTD
PMID:17682004
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression multiple interactions
ISO
Arecoline results in increased expression of PTGS2; Arecoline results in increased expression of PTGS2 mRNA [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein; Dinoprostone inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]
CTD
PMID:16311067 PMID:17682004 PMID:26464283
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rad1
RAD1 checkpoint DNA exonuclease
decreases expression
ISO
Arecoline results in decreased expression of RAD1 mRNA
CTD
PMID:17682004
NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689
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Rad50
RAD50 double strand break repair protein
increases expression
ISO
Arecoline results in increased expression of RAD50 mRNA
CTD
PMID:17682004
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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Serpine1
serpin family E member 1
increases expression
ISO
Arecoline results in increased expression of SERPINE1 protein
CTD
PMID:26908192
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc2a4
solute carrier family 2 member 4
increases expression
EXP
Arecoline results in increased expression of SLC2A4 mRNA
CTD
PMID:20724125
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Smc1a
structural maintenance of chromosomes 1A
decreases expression
ISO
Arecoline results in decreased expression of SMC1A mRNA
CTD
PMID:17682004
NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056
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Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Arecoline results in increased expression of STAT3 protein
CTD
PMID:34999050
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
Arecoline results in increased expression of TIMP1 mRNA; Arecoline results in increased expression of TIMP1 protein
CTD
PMID:16311067
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein Arecoline results in increased expression of TP53 protein
CTD
PMID:22108589
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Uggt1
UDP-glucose glycoprotein glucosyltransferase 1
decreases expression
ISO
Arecoline results in decreased expression of UGGT1 mRNA
CTD
PMID:17682004
NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467
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Vim
vimentin
increases expression multiple interactions
ISO
Arecoline results in increased expression of VIM protein U 0126 inhibits the reaction [Arecoline results in increased expression of VIM protein]
CTD
PMID:32441858
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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