Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arecoline
go back to main search page
Accession:CHEBI:2814 term browser browse the term
Definition:A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Synonyms:exact_synonym: methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
 related_synonym: Formula=C8H13NO2;   InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3;   InChIKey=HJJPJSXJAXAIPN-UHFFFAOYSA-N;   SMILES=COC(=O)C1=CCCN(C)C1;   arecaidine methyl ester;   arecaline;   arecholine;   arekolin;   methylarecaiden;   methylarecaidin
 xref: CAS:63-75-2;   DrugBank:DB04365;   HMDB:HMDB0030353;   KEGG:C10129;   KNApSAcK:C00002020;   LINCS:LSM-15214
 xref_mesh: MESH:D001115
 xref: PMID:21809341;   PMID:22493525;   PMID:23525646;   PMID:23895157;   Patent:CN101411705;   Patent:CN102464607;   Patent:US2506458;   Reaxys:123045;   Wikipedia:Arecoline


show annotations for term's descendants           Sort by:
arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 ISO U 0126 inhibits the reaction [Arecoline results in increased expression of ACTA2 protein]
Arecoline results in increased expression of ACTA2 mRNA; Arecoline results in increased expression of ACTA2 protein		 CTD PMID:32441858 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:17234337 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 decreases expression ISO Arecoline results in decreased expression of AKR1A1 mRNA CTD PMID:17682004 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation		 ISO
EXP		 [arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [AKT activator SC79 results in decreased phosphorylation of AKT1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein]
Arecoline affects the phosphorylation of AKT1 protein		 CTD PMID:30910432 PMID:33929070 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression ISO Arecoline results in decreased expression of ALDH9A1 mRNA CTD PMID:17682004 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO Arecoline results in decreased expression of APEX1 mRNA CTD PMID:17682004 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Ar androgen receptor increases expression EXP Arecoline results in increased expression of AR mRNA; Arecoline results in increased expression of AR protein CTD PMID:21741983 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP Arecoline results in increased expression of BAK1 protein CTD PMID:33929070 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP		 Arecoline results in decreased expression of BCL2 protein CTD PMID:22108589 PMID:33929070 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Arecoline results in increased expression of BCL2L1 protein CTD PMID:33929070 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP Arecoline affects the expression of and results in increased cleavage of BID protein CTD PMID:33929070 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Arecoline results in decreased expression of BRCA1 mRNA CTD PMID:17682004 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO
EXP		 Arecoline results in increased activity of CASP3 protein
Arecoline results in increased cleavage of CASP3 protein		 CTD PMID:22108589 PMID:33929070 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage EXP Arecoline results in increased cleavage of CASP8 protein CTD PMID:33929070 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage EXP Arecoline results in increased cleavage of CASP9 protein CTD PMID:33929070 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression EXP Arecoline analog results in decreased expression of CAT CTD PMID:25056785 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO Arecoline results in increased secretion of CCL5 protein CTD PMID:21297082 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 EXP
ISO		 Arecoline results in increased expression of CCND1 mRNA; Arecoline results in increased expression of CCND1 protein
[arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [AKT activator SC79 results in decreased expression of CCND1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased expression of CCND1 protein		 CTD PMID:21741983 PMID:30910432 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnh cyclin H decreases expression ISO Arecoline results in decreased expression of CCNH mRNA CTD PMID:17682004 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression		 ISO [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
Arecoline results in decreased expression of CDC25C protein		 CTD PMID:22108589 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression		 ISO U 0126 inhibits the reaction [Arecoline results in decreased expression of CDH1 protein] CTD PMID:32441858 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 increases expression ISO Arecoline results in increased expression of CDH2 protein CTD PMID:32441858 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases activity
multiple interactions		 ISO Arecoline results in decreased activity of CDK1 protein
[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein		 CTD PMID:22108589 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Arecoline results in increased expression of CDK4 mRNA; Arecoline results in increased expression of CDK4 protein CTD PMID:21741983 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO Arecoline results in decreased expression of CHAF1A mRNA CTD PMID:17682004 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO Arecoline results in decreased expression of CHAF1B mRNA CTD PMID:17682004 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding
multiple interactions		 ISO CHRM3 protein binds to Arecoline
brucine promotes the reaction [Arecoline binds to CHRM3 protein]		 CTD PMID:9224827 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Col4a6 collagen type IV alpha 6 chain increases expression ISO Arecoline results in increased expression of COL4A6 protein CTD PMID:32441858 NCBI chr  X:104,766,463...105,117,499
Ensembl chr  X:104,766,957...105,117,500 		JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of CTNNB1 protein CTD PMID:26464283 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:17234337 PMID:17707585 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity EXP Arecoline analog results in increased activity of CYP1A2 protein CTD PMID:25056785 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO Arecoline results in decreased expression of CYP26B1 mRNA CTD PMID:17682004 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP Arecoline analog results in increased activity of CYP2E1 protein CTD PMID:25056785 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dclre1b DNA cross-link repair 1B decreases expression ISO Arecoline results in decreased expression of DCLRE1B mRNA CTD PMID:17682004 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Arecoline results in increased expression of DDIT4 mRNA CTD PMID:17682004 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 increases expression ISO arecoline increases expression of DDR1 mRNA and protein in human cancer cell line OKF4/hTERT RGD PMID:31253192 RGD:151347620 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO Arecoline results in increased expression of DNAJA1 mRNA CTD PMID:17682004 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO Arecoline results in decreased expression of EEF1E1 mRNA CTD PMID:17682004 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of EGFR protein modified form; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein] CTD PMID:26464283 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30910432 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO Arecoline results in decreased expression of ERCC2 mRNA CTD PMID:17682004 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Fadd Fas associated via death domain increases expression EXP Arecoline results in increased expression of FADD protein CTD PMID:33929070 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fancg FA complementation group G decreases expression ISO Arecoline results in decreased expression of FANCG mRNA CTD PMID:17682004 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Arecoline results in increased expression of FAS protein CTD PMID:33929070 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression EXP Arecoline results in increased expression of FASLG protein CTD PMID:33929070 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO arecoline cotreated with dimethyl sulfoxide increases expression of Fat1 protein in tongue RGD PMID:30624777 RGD:151347668 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Arecoline results in increased expression of FN1 protein CTD PMID:26908192 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the expression of FOS protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of FOS protein CTD PMID:26464283 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Arecoline results in increased expression of FSHB protein CTD PMID:21741983 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP Arecoline results in increased expression of GATA4 protein CTD PMID:34999050 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Arecoline results in increased expression of GDF15 mRNA CTD PMID:17682004 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gss glutathione synthetase decreases expression ISO Arecoline results in decreased expression of GSS mRNA CTD PMID:17682004 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 decreases expression ISO Arecoline results in decreased expression of GTF2H5 mRNA CTD PMID:17682004 NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO arecoline cotreated with dimethyl sulfoxide increases expression of Hes1 protein in tongue RGD PMID:30624777 RGD:151347668 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hspa14 heat shock protein family A (Hsp70) member 14 increases expression ISO Arecoline results in increased expression of HSPA14 mRNA CTD PMID:17682004 NCBI chr17:74,728,945...74,749,727
Ensembl chr17:74,728,899...74,749,727 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il6 interleukin 6 decreases secretion
increases expression
decreases expression		 ISO
EXP		 Arecoline results in decreased secretion of IL6 protein
Arecoline results in increased expression of IL6 protein
Arecoline results in decreased expression of IL6 mRNA		 CTD PMID:22108589 PMID:34999050 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Arecoline inhibits the reaction [INS1 protein results in increased uptake of Glucose] CTD PMID:20406654 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation EXP Arecoline results in increased phosphorylation of JAK2 protein CTD PMID:34999050 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases expression ISO Arecoline results in decreased expression of LCMT1 mRNA CTD PMID:17682004 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Arecoline results in increased expression of LHB protein CTD PMID:21741983 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Maoa monoamine oxidase A decreases expression ISO Arecoline results in decreased expression of MAOA mRNA CTD PMID:17682004 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 increases expression EXP Arecoline results in increased expression of MAP2K5 protein CTD PMID:34999050 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein]
Arecoline results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK1 protein]		 CTD PMID:26464283 PMID:32441858 PMID:34999050 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein]
Arecoline results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK3 protein]		 CTD PMID:26464283 PMID:32441858 PMID:34999050 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 increases phosphorylation EXP Arecoline results in increased phosphorylation of MAPK7 protein CTD PMID:34999050 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Arecoline results in increased phosphorylation of MAPK8 protein CTD PMID:34999050 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Arecoline results in increased phosphorylation of MAPK9 protein CTD PMID:34999050 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mir136 microRNA 136 increases expression ISO Arecoline results in increased expression of MIR136 CTD PMID:21750350 NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177 		JBrowse link
G Mir143 microRNA 143 increases expression ISO Arecoline results in increased expression of MIR143 CTD PMID:21750350 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir145 microRNA 145 increases expression ISO Arecoline results in increased expression of MIR145 CTD PMID:21750350 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir23a microRNA 23a increases expression ISO Arecoline results in increased expression of MIR23A CTD PMID:21750350 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir26a microRNA 26a increases expression ISO Arecoline results in increased expression of MIR26A1 CTD PMID:21750350 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir26b microRNA 26b increases expression ISO Arecoline results in increased expression of MIR26B CTD PMID:21750350 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680 		JBrowse link
G Mir30a microRNA 30a increases expression ISO Arecoline results in increased expression of MIR30A CTD PMID:21750350 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO Arecoline results in decreased expression of MLH1 mRNA CTD PMID:17682004 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases secretion
increases expression		 ISO
EXP		 Arecoline results in decreased secretion of MMP2 protein
Arecoline results in increased expression of MMP2 protein		 CTD PMID:16311067 PMID:33929070 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP Arecoline results in increased expression of MMP9 protein CTD PMID:33929070 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Arecoline results in decreased expression of MSH2 mRNA CTD PMID:17682004 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions		 ISO Arecoline results in increased expression of MT1A mRNA
Benzo(a)pyrene promotes the reaction [Arecoline results in increased expression of MT1A mRNA]		 CTD PMID:17418620 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of MTOR protein CTD PMID:30910432 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myog myogenin decreases expression ISO Arecoline results in decreased expression of MYOG protein CTD PMID:23933062 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Nat8 N-acetyltransferase 8 decreases expression ISO Arecoline results in decreased expression of NAT8 mRNA CTD PMID:17682004 NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 increases expression EXP Arecoline results in increased expression of NFATC3 protein CTD PMID:34999050 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Notch1 notch receptor 1 increases expression ISO arecoline cotreated with dimethyl sulfoxide increases expression of Notch1 protein in tongue RGD PMID:30624777 RGD:151347668 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nppb natriuretic peptide B increases expression EXP Arecoline results in increased expression of NPPB protein CTD PMID:33929070 PMID:34999050 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in increased expression of PHLPP2 mRNA; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein] CTD PMID:30910432 NCBI chr19:37,835,125...37,901,804
Ensembl chr19:37,835,125...37,905,513 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP Arecoline results in increased expression of PIK3R1 mRNA CTD PMID:20724125 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression EXP Arecoline results in increased expression of PPP3CA protein CTD PMID:34999050 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO Arecoline results in decreased expression of PRKDC mRNA CTD PMID:17682004 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Arecoline results in increased expression of PTGS2; Arecoline results in increased expression of PTGS2 mRNA
[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein; Dinoprostone inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]		 CTD PMID:16311067 PMID:17682004 PMID:26464283 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease decreases expression ISO Arecoline results in decreased expression of RAD1 mRNA CTD PMID:17682004 NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689 		JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO Arecoline results in increased expression of RAD50 mRNA CTD PMID:17682004 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Arecoline results in increased expression of SERPINE1 protein CTD PMID:26908192 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Arecoline results in increased expression of SLC2A4 mRNA CTD PMID:20724125 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression ISO Arecoline results in decreased expression of SMC1A mRNA CTD PMID:17682004 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Arecoline results in increased expression of STAT3 protein CTD PMID:34999050 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Arecoline results in increased expression of TIMP1 mRNA; Arecoline results in increased expression of TIMP1 protein CTD PMID:16311067 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
Arecoline results in increased expression of TP53 protein		 CTD PMID:22108589 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 decreases expression ISO Arecoline results in decreased expression of UGGT1 mRNA CTD PMID:17682004 NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467 		JBrowse link
G Vim vimentin increases expression
multiple interactions		 ISO Arecoline results in increased expression of VIM protein
U 0126 inhibits the reaction [Arecoline results in increased expression of VIM protein]		 CTD PMID:32441858 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19589
          metabolite 19575
            arecoline 102
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      chalcogen 19603
                        oxygen atom 19575
                          oxygen molecular entity 19575
                            hydroxides 19379
                              organic hydroxy compound 18986
                                alcohol 15733
                                  aliphatic alcohol 11894
                                    alkyl alcohol 11801
                                      methanol 3969
                                        methyl ester 3915
                                          arecoline 102
paths to the root