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Gene: Dclre1b (DNA cross-link repair 1B) Rattus norvegicus

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Symbol:

Dclre1b

Name:

DNA cross-link repair 1B

RGD ID:

1310343

Description:

Predicted to enable several functions, including 5'-3' DNA exonuclease activity; beta-lactamase activity; and protein homodimerization activity. Predicted to be involved in DNA metabolic process. Predicted to be located in centrosome; chromosome, telomeric region; and nuclear body. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B); INTERACTS WITH 17beta-estradiol; bisphenol A; fenvalerate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

5' exonuclease Apollo; beta-lactamase MBLAC2; DNA cross-link repair 1B protein; DNA cross-link repair 1B, PSO2 homolog; DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae); LOC310745; MGC114481; SNM1 homolog B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DCLRE1B (DNA cross-link repair 1B)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dclre1b (DNA cross-link repair 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dclre1b (DNA cross-link repair 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DCLRE1B (DNA cross-link repair 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DCLRE1B (DNA cross-link repair 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DCLRE1B (DNA cross-link repair 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DCLRE1B (DNA cross-link repair 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DCLRE1C (DNA cross-link repair 1C)	HGNC	Inparanoid
Homo sapiens (human):	NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DCLRE1B (DNA cross-link repair 1B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dclre1b (DNA cross-link repair 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dclre1b (DNA cross-link repair 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mrt-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dclre1b	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	193,998,350 - 194,006,873 (-)	NCBI		GRCr8
mRatBN7.2	2	191,309,909 - 191,318,399 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	191,309,913 - 191,318,423 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	198,906,905 - 198,915,386 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	196,779,634 - 196,788,115 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	191,596,608 - 191,605,089 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	206,285,085 - 206,293,599 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	206,285,089 - 206,293,599 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	225,708,795 - 225,717,309 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	199,025,718 - 199,034,230 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	198,988,471 - 198,996,984 (-)	NCBI
Celera	2	183,781,669 - 183,790,181 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Dyskeratosis Congenita (ISO)

Autosomal Recessive Dyskeratosis Congenita 8 (ISO)

Fanconi anemia complementation group C (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 47 (ISO)

Hoyeraal Hreidarsson Syndrome (ISO)

RASopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

all-trans-retinoic acid (ISO)

arecoline (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cannabidiol (ISO)

CGP 52608 (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

ethanol (ISO)

fenvalerate (EXP)

formaldehyde (ISO)

gentamycin (EXP)

glyphosate (ISO)

leflunomide (ISO)

maneb (ISO)

N-ethyl-N-nitrosourea (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

resveratrol (ISO)

rifampicin (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA repair (IEA)

double-strand break repair via nonhomologous end joining (IBA)

interstrand cross-link repair (IBA,IEA,ISO)

protection from non-homologous end joining at telomere (IEA,ISO,ISS)

telomere capping (ISO)

telomere maintenance (IBA,ISO,ISS)

telomere maintenance via telomere lengthening (IEA,ISO)

telomeric 3' overhang formation (IEA,ISO,ISS)

telomeric loop formation (IEA,ISO,ISS)

Cellular Component

centrosome (IEA,ISO,ISS)

chromosome, telomeric region (IEA,ISO,ISS)

cytoplasm (IEA)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

nucleus (IEA)

Molecular Function

5'-3' DNA exonuclease activity (IBA)

5'-3' exonuclease activity (IEA,ISO,ISS)

beta-lactamase activity (IEA,ISO,ISS)

damaged DNA binding (IBA)

exonuclease activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

protein-containing complex binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:16730175	PMID:18202258	PMID:19135898	PMID:19197158	PMID:20479256	PMID:20551906	PMID:20619712	PMID:20655466	PMID:22692201	PMID:24270157	PMID:25943107

Genomics

Comparative Map Data

Dclre1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	193,998,350 - 194,006,873 (-)	NCBI		GRCr8
mRatBN7.2	2	191,309,909 - 191,318,399 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	191,309,913 - 191,318,423 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	198,906,905 - 198,915,386 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	196,779,634 - 196,788,115 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	191,596,608 - 191,605,089 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	206,285,085 - 206,293,599 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	206,285,089 - 206,293,599 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	225,708,795 - 225,717,309 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	199,025,718 - 199,034,230 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	198,988,471 - 198,996,984 (-)	NCBI
Celera	2	183,781,669 - 183,790,181 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

DCLRE1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	113,904,619 - 113,914,086 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	113,904,619 - 113,914,086 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	114,447,241 - 114,456,708 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	114,249,561 - 114,258,217 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	114,160,079 - 114,168,734	NCBI
Celera	1	112,677,139 - 112,685,932 (+)	NCBI		Celera
Cytogenetic Map	1	p13.2	NCBI
HuRef	1	112,306,040 - 112,314,841 (+)	NCBI		HuRef
CHM1_1	1	114,562,775 - 114,571,568 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	113,916,281 - 113,925,748 (+)	NCBI		T2T-CHM13v2.0

Dclre1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	103,707,921 - 103,716,703 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	103,707,921 - 103,716,760 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	103,800,605 - 103,809,387 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	103,800,605 - 103,809,444 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	103,604,528 - 103,613,310 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	103,929,666 - 103,938,448 (-)	NCBI		MGSCv36	mm8
Celera	3	106,003,520 - 106,012,334 (-)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI
cM Map	3	45.52	NCBI

Dclre1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955435	17,173,975 - 17,179,986 (+)	NCBI	ChiLan1.0	ChiLan1.0

DCLRE1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	106,564,031 - 106,571,091 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	106,157,486 - 106,164,503 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	88,643,664 - 88,651,962 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	123,692,921 - 123,701,403 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	123,692,915 - 123,701,403 (-)	Ensembl	panpan1.1		panPan2

DCLRE1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	51,711,267 - 51,716,806 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	51,711,284 - 51,716,345 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	51,362,655 - 51,368,194 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	52,589,546 - 52,595,104 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	52,589,468 - 52,595,469 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	51,596,829 - 51,602,368 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	51,665,109 - 51,670,657 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	52,237,640 - 52,243,174 (+)	NCBI		UU_Cfam_GSD_1.0

DCLRE1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	106,646,011 - 106,656,452 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	106,646,591 - 106,656,490 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	116,854,880 - 116,861,827 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCLRE1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	19,750,106 - 19,757,190 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	19,748,898 - 19,756,901 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	22,518,633 - 22,527,397 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	328
Count of miRNA genes:	210
Interacting mature miRNAs:	259
Transcripts:	ENSRNOT00000026213
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
61458	Bp10	Blood pressure QTL 10	3.42		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	191709311	217961898	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	192287802	229609668	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298083	Bp158	Blood pressure QTL 158	2.62		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	191709311	217961898	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	192287802	221089121	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
7488929	Bp366	Blood pressure QTL 366		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	187663373	195783351	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat

Markers in Region

RH133747

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	191,309,976 - 191,310,126 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	206,285,153 - 206,285,302	NCBI	Rnor6.0
Rnor_5.0	2	225,708,863 - 225,709,012	UniSTS	Rnor5.0
RGSC_v3.4	2	199,025,784 - 199,025,933	UniSTS	RGSC3.4
Celera	2	183,781,735 - 183,781,884	UniSTS
RH 3.4 Map	2	1327.9	UniSTS
Cytogenetic Map	2	q34	UniSTS

AA957141

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	191,311,825 - 191,312,073 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	206,287,002 - 206,287,249	NCBI	Rnor6.0
Rnor_5.0	2	225,710,712 - 225,710,959	UniSTS	Rnor5.0
RGSC_v3.4	2	199,027,633 - 199,027,880	UniSTS	RGSC3.4
Celera	2	183,783,584 - 183,783,831	UniSTS
RH 3.4 Map	2	1323.7	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001389222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026213 ⟹ ENSRNOP00000026213

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	191,309,913 - 191,318,423 (-)	Ensembl
Rnor_6.0 Ensembl	2	206,285,089 - 206,293,599 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080702 ⟹ ENSRNOP00000072954

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	191,316,299 - 191,318,423 (-)	Ensembl
Rnor_6.0 Ensembl	2	206,287,245 - 206,293,275 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115006 ⟹ ENSRNOP00000086363

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	191,309,913 - 191,318,367 (-)	Ensembl

RefSeq Acc Id:

NM_001025687 ⟹ NP_001020858

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,998,350 - 194,006,840 (-)	NCBI
mRatBN7.2	2	191,309,909 - 191,318,399 (-)	NCBI
Rnor_6.0	2	206,285,087 - 206,293,599 (-)	NCBI
Rnor_5.0	2	225,708,795 - 225,717,309 (-)	NCBI
RGSC_v3.4	2	199,025,718 - 199,034,230 (-)	RGD
Celera	2	183,781,669 - 183,790,181 (-)	RGD

Sequence:

show sequence

CGGAAATCAGCTACTAGAGTCTGTCTCCCCGCCGCCGCGCGCGCTTTGACAAAGTTGCGGACTG
GGCCTAAGCTCCCGCGCACGGGTGGCTTCTGGCCTTGTTCTTGAATCCACATGTCGTTGGGACG
CTGTCGTGGAAGCCTCACCCAGGAGTGCAGTTCCCGCGAAGACCCCACTGGGTGACTCCTCAAC
TCTGCCACCATGAACGGGGTCGTAATCCCCCAAACACCCATCGCTGTGGATTTTTGGAGCCTGC
GCCGTGCTGGTACCGCGCGGCTCTTCTTCTTATCCCACATGCACTGTGACCACACGGTGGGCCT
GTCTAGCACTTGGGCACGGCCCCTCTACTGCTCTCCCATCACTGCCCACCTCTTGCATCGTCGC
CTGCAGGTGTCTAAGCAGTGGATCCGAGCTCTGGAGATTGGTGAGAGCCATGTATTACTTCTAG
ATGAAATTGGACAAGAAACCATGACTGTAACCCTCATAGATGCCAATCACTGTCCTGGTTCTGT
CATGTTTCTCTTTGAAGGATACTTTGGAACAATTCTCTACACAGGTGATTTTCGATATACACCG
TCCATGCTGAAGGAGCCTGCTCTGACACTAGGGAAACAGATTCATACTTTATATCTAGACAACA
CCAATTGCAACCCAGCCCTTGTTCTTCCTTCCCGACAGGAAGCTACTCAACAGATTATCCAGCT
AATCCGACAGTTCCCCCAACACAACATAAAGATTGGCCTCTATAGTCTAGGAAAAGAATCACTG
CTGGAGCAGCTAGCCCTTGAGTTTCAGACCTGGGTGGTATTGAGTCCTCAACGCCTGGAGTTGG
TACAGCTGCTGGGCCTGGCAGACGTGTTCACAGTGGAGGAAGAAGCTGGGCGAATCCACGCTGT
GGACCACATGGAAATCTGCCATTCGGCCATGCTTCAGTGGAACCAGACCCACCCCACCATTGCT
ATTTTCCCCACAAGCCGGAAAATACGAAGCCCTCACCCCAGCATCTACAGCATCCCTTACTCTG
ACCATTCATCCTACTCTGAGCTTCGAGCATTTGTTGCAGCTCTGAGGCCTTGCCAGGTGGTGCC
CATAGTCCGTGAACAGCCTTGTGGAGAGTTTTTTTCAGGATAGCTTGAGTCCTAGACTCTCTAT
GCCTCTGATTCCACACTCTGTGCAACAATACATGAGTTCCTCCTCGAGGAAAACAAATGTGTTT
TGGCAGTTAGAAAGGAGGCTAAAGAGGCCAAGAACCCAGGGTGTTGTGTTTGAATCCCCTGAGG
AGAAAGCTGATCAGGTTAAAGTTGACAGAGACTCAAAGAAACACAAAAAAGAAAGCCTCTCCCC
CTGGGCTGGGTGCCTTTCGAGGCTTTGCCCCCATCCTCTGCAGGCCAGGAAGCAGTTGTTCCCA
GATTTCTGCAGAAAAGAAGGTGATGAGCCAGTTCTTTTCTGTGACTCCAACAAGATGGCGACTG
TGTTGACTGCCCCATTGGAACTTTCAGTGCAGTTACAGCCTGTAGATGAGTTTCCCTTTCCAGA
AACCAGGGAGGAAATTGGCTTAGGGTCCCCATTGTGGTCAGGGGGAGGCAGTGGCTCACCAACG
AGAGGGAAGCAAAGCAATGGCATGGGCTGTGGTTCTCCCCCAACTCACATTAGCAGAACCACTC
ATCTAACTCCTGAGTCCGGGGGCCTGGCGTTAAAATACCTTCTTACTCCAGTGGATTTCCTCCA
AGCAGGGTTCTCCTCCAGGAACTTTGACCAGCAAGTGGAAAAACACCAGAGAGTGCAGTGTAAC
AATCCTGCAGTTATGAACACAGTGGATGATGTCTAGTGGCAAGAGTTGGCTTGGTGTCTTCCTT
TACAGAATCCTGTGGCTCACTCTGAGTGGCTCTTCTAAAGCTTTTTATGAAGTCCTGGTGCCTA
AGAAACCCTTAGTTTTATAGTACATTTATTGCTTAATTTTATTATATTTAAGAAACAGTTTTCA
TTATATAAACTATTCAGTGTTCATAAGCACATTGAAAGTTCTTAGAAGTTCCATAGCAATTTAA
TTTGTTCCACTTGGTTTAACCCAGTTTTTCTCAACCCTTTATCAGCATCAAGTTTGTTTGTTTT
TTTGTTTTGTTAGAGTCTGAATCAAAAAGAATCAGGCTTGTCCCGTTGTCATTTCCTTTGTTAT
ATCCCAGTCCCCAAGTTCCCATCACCCTTTTTCCAGATAAAAGTCTACATTATTTATTTTCAGA
CTGTAATTTATAGTGCTGGAGGATAAAGTGGGGGTGCAGAGCAGCATGTTCTAACCCTGACTGT
CACTGACTCGCTGTGACATGACCCTACCCAAGTAACTTCCTGTCTCTGCCTCTTGGAGTGAACA
GGAAACCATGAAAAGGCATTGAAACAGTGTTAGGAAAATAACACCTTCCTCCTGCGTGAAGGGG
TTTAGTAACTGTCATGAGACCTCCATCTGGAACATAGCCGTTTGGAGGTTAGACACCACGCACC
ATGGTGGCGCATGGGACAAGCTGAACATTAAGGTTTAGAACATGTCAGTGCTACTGGATGCTTG
CAGACACTGCTTTGTTAAAGCTACAGAAGATCAAATGTGCTGCCAGATATCCTCTGATGGTTCA
CATAGCTGGGATTTTCCCCCCCACCCCCACAAGTTTGAATTAGGGAGCCAGAGCACAGAGCTTG
TTTGTTTTAGTATCCAGGGGAGAGAGACCAAGGAGCCAGCTGGCTGGAACGGGTCAGAGTATGC
AGTTCTACCCTGCCCTGCTCATAACCTGACAAAATGCCAAACCAATAAGCAAGACAGCTGATAG
CAGAGCCATGAGGAAATGTGCTCTGGGAGGGTGCAGGCAAGGAGCAGCTTAGGCCTGGAACCAT
GAGCAGTAACAATAAAGAAAGTCGCCTCACCCTTGGGAAGGAGGGAGGAGCTCTGCTACTTTGG
GAGGGAGAAGTGGAGTTTATTGAGCAAAATAAGACTTTGCTCTCGGACACACTGTACTCAGTTC
TGTTTTTGTCAGTGACCTTCCTATAAACCTCTAAGGGCTTCATAGGAACTGCAGCAGGTGAGGC
ATGTGGTTCAACAGGAAACCTAGACATTGGCTGGAATCCAGGGCACATGGCAAATTGTTTGAAT
AGATGAGCCTTACTCAGCTGCAATGTGGGGGCTGAGATATCTACCTCCCATGATTGCTATGCAG
ACTATTGGTAAAATTCCCTAGCTCATTGCCTGGCACATGACAGTATTTCAAATATTGGTTTTCG
TAGCTAAAAGTCTAGCTCTGGTAGGATGGGTGCTTAGCAAACTGAAATTCTGGATTCTATCCTG
AGTGCCAAAAAAAGAGGCAATCTTCAAAACAATTTTCTATGAAAACACAAAGTTAAATGTTTTC
CACGTAGACTAGTTGATGGGCATTTTTCTAGTCTTTCTGAGGATATGTGTAAAATCTGTACATT
TTCAGAAGTAGGATATTTCACACATGTGCACACACACAAAGGGTGCAGAACAGATGGCCAAGTG
GTTAAGAGCTCTTAATGTGCTGCTCTTGAAGACCTGACTTTGGTTCCCAGCACCTTCATTGGGT
TGATCATAACTCAAGTTCCAGGGGTCTTTCACCTTCTGACCTCTGTGAATAACTGCACAAAAAC
TTGTATGGTCTCACACAATACACATAAATAAAAATTTTTAAATAATGTTTTGAAGGGGGCCAGG
GAGATGGCTCAGTGGGTAAAAGCACTTGTCACACAAACTGGTGAACTAGATTCAATCCCCAGAA
CCCACATAAAAGTGAAGGAGAACTGAGTCAATAAAGCTGTCCTCCAGCTGGTTGCCATGCTTGC
CTATGAACAATACTAAAAGGGGGGCCATAAGATAACACTGTATATGATTCCTTAATTCCTTAAT
TGGAACTCAAAGTGCCATTATAAAAAATGCTTTGTTAATAGGATGTAACTACATGTTAATAAAT
CATTCTCATATTATTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001389222 ⟹ NP_001376151

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,998,350 - 194,006,840 (-)	NCBI
mRatBN7.2	2	191,309,909 - 191,318,399 (-)	NCBI

RefSeq Acc Id:

XM_006233080 ⟹ XP_006233142

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,998,352 - 194,006,873 (-)	NCBI
mRatBN7.2	2	191,309,909 - 191,318,137 (-)	NCBI
Rnor_6.0	2	206,285,085 - 206,293,564 (-)	NCBI
Rnor_5.0	2	225,708,795 - 225,717,309 (-)	NCBI

Sequence:

show sequence

CGCGCGCGCTTTGACAAAGTTGCGGACTGGGCCTAAGCTCCCGCGCACGGGTGTGAGTAATGCT
CTCCGGGCTTCTTCCGCGTTGGGCGCTTCCACCCTGGCTGTCCCGAGCGCGGCCACCCTCTTTT
TCTTCACCCTGTCTACTTCTTCCATTTCTGGGATGGTTTTCCTTTAGGGCTTCTGGCCTTGTTC
TTGAATCCACATGTCGTTGGGACGCTGTCGTGGAAGCCTCACCCAGGAGTGCAGTTCCCGCGAA
GACCCCACTGGGTGACTCCTCAACTCTGCCACCATGAACGGGGTCGTAATCCCCCAAACACCCA
TCGCTGTGGATTTTTGGAGCCTGCGCCGTGCTGGTACCGCGCGGCTCTTCTTCTTATCCCACAT
GCACTGTGACCACACGGTGGGCCTGTCTAGCACTTGGGCACGGCCCCTCTACTGCTCTCCCATC
ACTGCCCACCTCTTGCATCGTCGCCTGCAGGTGTCTAAGCAGTGGATCCGAGCTCTGGAGATTG
GTGAGAGCCATGTATTACCTCTAGATGAAATTGGACAAGAAACCATGACTGTAACCCTCATAGA
TGCCAATCACTGTCCTGGTTCTGTCATGTTTCTCTTTGAAGGATACTTTGGAACAATTCTCTAC
ACAGGCCTCTATAGTCTAGGAAAAGAATCACTGCTGGAGCAGCTAGCCCTTGAGTTTCAGACCT
GGGTGGTATTGAGTCCTCAACGCCTGGAGTTGGTACAGCTGCTGGGCCTGGCAGACGTGTTCAC
AGTGGAGGAAGAAGCTGGGCGAATCCACGCTGTGGACCACATGGAAATCTGCCATTCGGCCATG
CTTCAGTGGAACCAGACCCACCCCACCATTGCTATTTTCCCCACAAGCCGGAAAATACGAAGCC
CTCACCCCAGCATCTACAGCATCCCTTACTCTGACCATTCATCCTACTCTGAGCTTCGAGCATT
TGTTGCAGCTCTGAGGCCTTGCCAGGTGGTGCCCATAGTCCGTGAACAGCCTTGTGGAGAGTTT
TTTCAGGATAGCTTGAGTCCTAGACTCTCTATGCCTCTGATTCCACACTCTGTGCAACAATACA
TGAGTTCCTCCTCGAGGAAAACAAATGTGTTTTGGCAGTTAGAAAGGAGGCTAAAGAGGCCAAG
AACCCAGGGTGTTGTGTTTGAATCCCCTGAGGAGAAAGCTGATCAGGTTAAAGTTGACAGAGAC
TCAAAGAAACACAAAAAAGAAAGCCTCTCCCCCTGGGCTGGGTGCCTTTCGAGGCTTTGCCCCC
ATCCTCTGCAGGCCAGGAAGCAGTTGTTCCCAGATTTCTGCAGAAAAGAAGGTGATGAGCCAGT
TCTTTTCTGTGACTCCAACAAGATGGCGACTGTGTTGACTGCCCCATTGGAACTTTCAGTGCAG
TTACAGCCTGTAGATGAGTTTCCCTTTCCAGAAACCAGGGAGGAAATTGGCTTAGGGTCCCCAT
TGTGGTCAGGGGGAGGCAGTGGCTCACCAACGAGAGGGAAGCAAAGCAATGGCATGGGCTGTGG
TTCTCCCCCAACTCACATTAGCAGAACCACTCATCTAACTCCTGAGTCCGGGGGCCTGGCGTTA
AAATACCTTCTTACTCCAGTGGATTTCCTCCAAGCAGGGTTCTCCTCCAGGAACTTTGACCAGC
AAGTGGAAAAACACCAGAGAGTGCAGTGTAACAATCCTGCAGTTATGAACACAGTGGATGATGT
CTAGTGGCAAGAGTTGGCTTGGTGTCTTCCTTTACAGAATCCTGTGGCTCACTCTGAGTGGCTC
TTCTAAAGCTTTTTATGAAGTCCTGGTGCCTAAGAAACCCTTAGTTTTATAGTACATTTATTGC
TTAATTTTATTATATTTAAGAAACAGTTTTCATTATATAAACTATTCAGTGTTCATAAGCACAT
TGAAAGTTCTTAGAAGTTCCATAGCAATTTAATTTGTTCCACTTGGTTTAACCCAGTTTTTCTC
AACCCTTTATCAGCATCAAGTTTGTTTGTTTTTTTGTTTTGTTAGAGTCTGAATCAAAAAGAAT
CAGGCTTGTCCCGTTGTCATTTCCTTTGTTATATCCCAGTCCCCAAGTTCCCATCACCCTTTTT
CCAGATAAAAGTCTACATTATTTATTTTCAGACTGTAATTTATAGTGCTGGAGGATAAAGTGGG
GGTGCAGAGCAGCATGTTCTAACCCTGACTGTCACTGACTCGCTGTGACATGACCCTACCCAAG
TAACTTCCTGTCTCTGCCTCTTGGAGTGAACAGGAAACCATGAAAAGGCATTGAAACAGTGTTA
GGAAAATAACACCTTCCTCCTGCGTGAAGGGGTTTAGTAACTGTCATGAGACCTCCATCTGGAA
CATAGCCGTTTGGAGGTTAGACACCACGCACCATGGTGGCGCATGGGACAAGCTGAACATTAAG
GTTTAGAACATGTCAGTGCTACTGGATGCTTGCAGACACTGCTTTGTTAAAGCTACAGAAGATC
AAATGTGCTGCCAGATATCCTCTGATGGTTCACATAGCTGGGATTTTCCCCCCCACCCCCACAA
GTTTGAATTAGGGAGCCAGAGCACAGAGCTTGTTTGTTTTAGTATCCAGGGGAGAGAGACCAAG
GAGCCAGCTGGCTGGAACGGGTCAGAGTATGCAGTTCTACCCTGCCCTGCTCATAACCTGACAA
AATGCCAAACCAATAAGCAAGACAGCTGATAGCAGAGCCATGAGGAAATGTGCTCTGGGAGGGT
GCAGGCAAGGAGCAGCTTAGGCCTGGAACCATGAGCAGTAACAATAAAGAAAGTCGCCTCACCC
TTGGGAAGGAGGGAGGAGCTCTGCTACTTTGGGAGGGAGAAGTGGAGTTTATTGAGCAAAATAA
GACTTTGCTCTCGGACACACTGTACTCAGTTCTGTTTTTGTCAGTGACCTTCCTATAAACCTCT
AAGGGCTTCATAGGAACTGCAGCAGGTGAGGCATGTGGTTCAACAGGAAACCTAGACATTGGCT
GGAATCCAGGGCACATGGCAAATTGTTTGAATAGATGAGCCTTACTCAGCTGCAATGTGGGGGC
TGAGATATCTACCTCCCATGATTGCTATGCAGACTATTGGTAAAATTCCCTAGCTCATTGCCTG
GCACATGACAGTATTTCAAATATTGGTTTTCGTAGCTAAAAGTCTAGCTCTGGTAGGATGGGTG
CTTAGCAAACTGAAATTCTGGATTCTATCCTGAGTGCCAAAAAAAGAGGCAATCTTCAAAACAA
TTTTCTATGAAAACACAAAGTTAAATGTTTTCCACGTAGACTAGTTGATGGGCATTTTTCTAGT
CTTTCTGAGGATATGTGTAAAATCTGTACATTTTCAGAAGTAGGATATTTCACACATGTGCACA
CACACAAAGGGTGCAGAACAGATGGCCAAGTGGTTAAGAGCTCTTAATGTGCTGCTCTTGAAGA
CCTGACTTTGGTTCCCAGCACCTTCATTGGGTTGATCATAACTCAAGTTCCAGGGGTCTTTCAC
CTTCTGACCTCTGTGAATAACTGCACAAAAACTTGTATGGTCTCACACAATACACATAAATAAA
AATTTTTAAATAATGTTTTGAAGGGGGCCAGGGAGATGGCTCAGTGGGTAAAAGCACTTGTCAC
ACAAACTGGTGAACTAGATTCAATCCCCAGAACCCACATAAAAGTGAAGGAGAACTGAGTCAAT
AAAGCTGTCCTCCAGCTGGTTGCCATGCTTGCCTATGAACAATACTAAAAGGGGGGCCATAAGA
TAACACTGTATATGATTCCTTAATTCCTTAATTGGAACTCAAAGTGCCATTATAAAAAATGCTT
TGTTAATAGGATGTAACTACATGTTAATAAATCATTCTCATATTATTCAACA

hide sequence

RefSeq Acc Id:

XM_039102403 ⟹ XP_038958331

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	193,998,352 - 194,005,632 (-)	NCBI
mRatBN7.2	2	191,309,909 - 191,317,191 (-)	NCBI

RefSeq Acc Id:

XM_039102405 ⟹ XP_038958333

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	194,001,699 - 194,006,851 (-)	NCBI
mRatBN7.2	2	191,313,258 - 191,318,137 (-)	NCBI

RefSeq Acc Id:

XM_039102406 ⟹ XP_038958334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	194,001,699 - 194,006,846 (-)	NCBI
mRatBN7.2	2	191,313,258 - 191,318,137 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020858	(Get FASTA)	NCBI Sequence Viewer
	NP_001376151	(Get FASTA)	NCBI Sequence Viewer
	XP_006233142	(Get FASTA)	NCBI Sequence Viewer
	XP_038958331	(Get FASTA)	NCBI Sequence Viewer
	XP_038958333	(Get FASTA)	NCBI Sequence Viewer
	XP_038958334	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98939	(Get FASTA)	NCBI Sequence Viewer
	EDL85472	(Get FASTA)	NCBI Sequence Viewer
	EDL85473	(Get FASTA)	NCBI Sequence Viewer
	EDL85474	(Get FASTA)	NCBI Sequence Viewer
	EDL85475	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026213.7
	ENSRNOP00000072954.2
	ENSRNOP00000086363.1
GenBank Protein	Q4KLY6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020858 ⟸ NM_001025687

- UniProtKB:

Q4KLY6 (UniProtKB/Swiss-Prot), G3V8I3 (UniProtKB/TrEMBL), A6K3M4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNGVVIPQTPIAVDFWSLRRAGTARLFFLSHMHCDHTVGLSSTWARPLYCSPITAHLLHRRLQV
SKQWIRALEIGESHVLLLDEIGQETMTVTLIDANHCPGSVMFLFEGYFGTILYTGDFRYTPSML
KEPALTLGKQIHTLYLDNTNCNPALVLPSRQEATQQIIQLIRQFPQHNIKIGLYSLGKESLLEQ
LALEFQTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHMEICHSAMLQWNQTHPTIAIFP
TSRKIRSPHPSIYSIPYSDHSSYSELRAFVAALRPCQVVPIVREQPCGEFFSG

hide sequence

RefSeq Acc Id:	XP_006233142 ⟸ XM_006233080
- Peptide Label:	isoform X1
- UniProtKB:	Q4KLY6 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNGVVIPQTPIAVDFWSLRRAGTARLFFLSHMHCDHTVGLSSTWARPLYCSPITAHLLHRRLQV SKQWIRALEIGESHVLPLDEIGQETMTVTLIDANHCPGSVMFLFEGYFGTILYTGLYSLGKESL LEQLALEFQTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHMEICHSAMLQWNQTHPTIA IFPTSRKIRSPHPSIYSIPYSDHSSYSELRAFVAALRPCQVVPIVREQPCGEFFQDSLSPRLSM PLIPHSVQQYMSSSSRKTNVFWQLERRLKRPRTQGVVFESPEEKADQVKVDRDSKKHKKESLSP WAGCLSRLCPHPLQARKQLFPDFCRKEGDEPVLFCDSNKMATVLTAPLELSVQLQPVDEFPFPE TREEIGLGSPLWSGGGSGSPTRGKQSNGMGCGSPPTHISRTTHLTPESGGLALKYLLTPVDFLQ AGFSSRNFDQQVEKHQRVQCNNPAVMNTVDDV hide sequence

Ensembl Acc Id:

ENSRNOP00000072954 ⟸ ENSRNOT00000080702

Ensembl Acc Id:

ENSRNOP00000026213 ⟸ ENSRNOT00000026213

RefSeq Acc Id:	NP_001376151 ⟸ NM_001389222
- UniProtKB:	Q4KLY6 (UniProtKB/Swiss-Prot), G3V8I3 (UniProtKB/TrEMBL), A6K3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958331 ⟸ XM_039102403
- Peptide Label:	isoform X2
- UniProtKB:	A6K3M5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958333 ⟸ XM_039102405
- Peptide Label:	isoform X3
- UniProtKB:	A0A0G2K494 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958334 ⟸ XM_039102406
- Peptide Label:	isoform X4
- UniProtKB:	A0A0G2K494 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000086363 ⟸ ENSRNOT00000115006

Protein Domains

DNA repair metallo-beta-lactamase Metallo-beta-lactamase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KLY6-F1-model_v2	AlphaFold	Q4KLY6	1-541	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691630

Promoter ID:

EPDNEW_R2155

Type:

initiation region

Name:

Dclre1b_1

Description:

DNA cross-link repair 1B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	206,293,506 - 206,293,566	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310343	AgrOrtholog
BioCyc Gene	G2FUF-51794	BioCyc
Ensembl Genes	ENSRNOG00000019367	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026213.7	UniProtKB/TrEMBL
	ENSRNOT00000080702.2	UniProtKB/TrEMBL
	ENSRNOT00000115006.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.12650	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.60.15.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7455348	IMAGE-MGC_LOAD
InterPro	DRMBL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Metallo-B-lactamas	UniProtKB/TrEMBL
	RibonucZ/Hydroxyglut_hydro	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:310745	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114481	IMAGE-MGC_LOAD
NCBI Gene	310745	ENTREZGENE
PANTHER	5' EXONUCLEASE APOLLO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DRMBL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lactamase_B_2	UniProtKB/TrEMBL
PharmGKB	DCLRE1B	RGD
PhenoGen	Dclre1b	PhenoGen
RatGTEx	ENSRNOG00000019367	RatGTEx
Superfamily-SCOP	SSF56281	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K494	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A125_RAT	UniProtKB/TrEMBL
	A6K3M4	ENTREZGENE, UniProtKB/TrEMBL
	A6K3M5	ENTREZGENE, UniProtKB/TrEMBL
	A6K3M8_RAT	UniProtKB/TrEMBL
	DCR1B_RAT	UniProtKB/Swiss-Prot
	G3V8I3	ENTREZGENE, UniProtKB/TrEMBL
	Q4KLY6	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Dclre1b	DNA cross-link repair 1B	Dclre1b	DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Dclre1b	DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)	Dclre1b_predicted	DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Dclre1b_predicted	DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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