DCLRE1B (DNA cross-link repair 1B) - Rat Genome Database

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Gene: DCLRE1B (DNA cross-link repair 1B) Canis lupus familiaris
Analyze
Symbol: DCLRE1B
Name: DNA cross-link repair 1B
RGD ID: 12281193
Description: ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); beta-lactamase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN telomere capping (ortholog); telomere maintenance (ortholog); telomere maintenance via telomere lengthening (ortholog); ASSOCIATED WITH hereditary spastic paraplegia 47 (ortholog); Hoyeraal Hreidarsson Syndrome (ortholog); FOUND IN centrosome (ortholog); chromosome, telomeric region (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5' exonuclease Apollo; DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1B protein; LOW QUALITY PROTEIN: 5' exonuclease Apollo
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,711,267 - 51,716,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,711,284 - 51,716,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1751,362,655 - 51,368,194 (+)NCBI
ROS_Cfam_1.01752,589,546 - 52,595,104 (+)NCBI
UMICH_Zoey_3.11751,596,829 - 51,602,368 (+)NCBI
UNSW_CanFamBas_1.01751,665,109 - 51,670,657 (+)NCBI
UU_Cfam_GSD_1.01752,237,640 - 52,243,174 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
DCLRE1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,711,267 - 51,716,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,711,284 - 51,716,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1751,362,655 - 51,368,194 (+)NCBI
ROS_Cfam_1.01752,589,546 - 52,595,104 (+)NCBI
UMICH_Zoey_3.11751,596,829 - 51,602,368 (+)NCBI
UNSW_CanFamBas_1.01751,665,109 - 51,670,657 (+)NCBI
UU_Cfam_GSD_1.01752,237,640 - 52,243,174 (+)NCBI
DCLRE1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1113,905,213 - 113,914,086 (+)EnsemblGRCh38hg38GRCh38
GRCh381113,904,619 - 113,914,086 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371114,447,241 - 114,456,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,249,561 - 114,258,217 (+)NCBINCBI36hg18NCBI36
Build 341114,160,079 - 114,168,734NCBI
Celera1112,677,139 - 112,685,932 (+)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1112,306,040 - 112,314,841 (+)NCBIHuRef
CHM1_11114,562,775 - 114,571,568 (+)NCBICHM1_1
Dclre1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,707,921 - 103,716,703 (-)NCBIGRCm39mm39
GRCm39 Ensembl3103,707,921 - 103,716,760 (-)Ensembl
GRCm383103,800,605 - 103,809,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,800,605 - 103,809,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv373103,604,528 - 103,613,310 (-)NCBIGRCm37mm9NCBIm37
MGSCv363103,929,666 - 103,938,448 (-)NCBImm8
Celera3106,003,520 - 106,012,334 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
Dclre1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22191,309,909 - 191,318,399 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2191,309,913 - 191,318,423 (-)Ensembl
Rnor_6.02206,285,085 - 206,293,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,285,089 - 206,293,599 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,708,795 - 225,717,309 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42199,025,718 - 199,034,230 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12198,988,471 - 198,996,984 (-)NCBI
Celera2183,781,669 - 183,790,181 (-)NCBICelera
Cytogenetic Map2q34NCBI
Dclre1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543517,173,975 - 17,179,986 (+)NCBIChiLan1.0ChiLan1.0
DCLRE1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11123,692,921 - 123,701,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,692,915 - 123,701,403 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0188,643,664 - 88,651,962 (-)NCBIMhudiblu_PPA_v0panPan3
DCLRE1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,646,010 - 106,656,452 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,646,591 - 106,656,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,854,880 - 116,861,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCLRE1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,750,106 - 19,757,190 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,748,898 - 19,756,901 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603822,518,633 - 22,527,397 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 5 5 6 8 8
Low 4 5 17 6 1 6 2 12 2 6
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005630634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022404864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038499254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038561818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038561819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038625888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038625889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038625890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038691824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038691825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038691826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_843181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000014735   ⟹   ENSCAFP00000013629
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1751,711,284 - 51,716,345 (+)Ensembl
RefSeq Acc Id: XM_005630634   ⟹   XP_005630691
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11751,711,267 - 51,716,806 (+)NCBI
Dog10K_Boxer_Tasha1751,362,655 - 51,368,194 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022404864   ⟹   XP_022260572
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11751,711,832 - 51,716,806 (+)NCBI
Dog10K_Boxer_Tasha1751,363,213 - 51,368,194 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038499254   ⟹   XP_038355182
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11751,596,829 - 51,602,368 (+)NCBI
RefSeq Acc Id: XM_038561818   ⟹   XP_038417746
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01752,237,640 - 52,243,174 (+)NCBI
RefSeq Acc Id: XM_038561819   ⟹   XP_038417747
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01752,237,640 - 52,243,174 (+)NCBI
RefSeq Acc Id: XM_038625888   ⟹   XP_038481816
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01751,665,109 - 51,670,657 (+)NCBI
RefSeq Acc Id: XM_038625889   ⟹   XP_038481817
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01751,665,109 - 51,670,657 (+)NCBI
RefSeq Acc Id: XM_038625890   ⟹   XP_038481818
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01751,665,667 - 51,670,657 (+)NCBI
RefSeq Acc Id: XM_038691824   ⟹   XP_038547752
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01752,589,547 - 52,595,104 (+)NCBI
RefSeq Acc Id: XM_038691825   ⟹   XP_038547753
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01752,589,546 - 52,595,104 (+)NCBI
RefSeq Acc Id: XM_038691826   ⟹   XP_038547754
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01752,590,105 - 52,595,104 (+)NCBI
RefSeq Acc Id: XM_843181   ⟹   XP_848274
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11751,711,267 - 51,716,806 (+)NCBI
Dog10K_Boxer_Tasha1751,362,655 - 51,368,194 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_848274   ⟸   XM_843181
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005630691   ⟸   XM_005630634
- Peptide Label: isoform X2
- UniProtKB: E2RLH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022260572   ⟸   XM_022404864
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000013629   ⟸   ENSCAFT00000014735
RefSeq Acc Id: XP_038355182   ⟸   XM_038499254
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038481816   ⟸   XM_038625888
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038481817   ⟸   XM_038625889
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038481818   ⟸   XM_038625890
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038547753   ⟸   XM_038691825
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038547752   ⟸   XM_038691824
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038547754   ⟸   XM_038691826
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038417746   ⟸   XM_038561818
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038417747   ⟸   XM_038561819
- Peptide Label: isoform X2

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 51715879 51715880 A G snv Australian Cattle dog (AC023), Alaskan Malamute (AM007), Bearded Collie (BD036), Basset (BH003), Basenji (BJ002), Basenji (BJ003), Cavalier King Charles Spaniel (CK023), Cocker Spaniel (CP003), Chow Chow (CW011), Chinese indigenous dogs (DQ2), Chinese indigenous dogs (DQ7), German Shepherd (DS051), Jack Russell Terrier (JR0034), Kunming Dog (KM5), Spanish Water Dog (PE002), Rhodesian Ridgeback (RR224), Greater Swiss Mountain Dog (SH008), Siberian Husky (SY046), Tibetan Mastiff (TM1), Tibetan Mastiff (TM7), Chinese indigenous dogs (YJ2), Chinese indigenous dogs (YJ5), Chinese indigenous dogs (YJ9), Yorkshire Terrier (YT003), Australian Terrier (AR001), American Staffordshire Terrier (AS006), Australian Shepherd (AU178), Berger Blanc Suisse (BB011), Border Collie (BC518), Bearded Collie (BD093), Bearded Collie (BD098), Beagle (BE020), Basenji (BJ001), Basenji (BJ004), Basenji (BJ005), Basenji (BJ006), Miniature Bullterrier (BT007), Bullterrier (BT012), Bullmastiff (BU002), Curly Coated Retriever (CR039), Great Dane (DD116), Dachshund (DH126), Doberman Pinscher (DO242), Doberman Pinscher (DO263), Chinese indigenous dogs (DQ1), Chinese indigenous dogs (DQ10), Chinese indigenous dogs (DQ4), Chinese indigenous dogs (DQ5), Chinese indigenous dogs (DQ6), Chinese indigenous dogs (DQ9), German Shepherd/Mixed breed (DS032), German Shepherd/Mixed breed (DS042), German Shepherd (DS043), German Shepherd (DS064), French Bulldog (FB065), Golden Retriever (GR0859), Golden Retriever (GR0892), German Shepherd (GS1), German Shepherd (GS10), German Shepherd (GS2), German Shepherd (GS3), German Shepherd (GS4), German Shepherd (GS6), German Shepherd (GS7), German Shepherd (GS8), German Shepherd (GS9), Heideterrier (HT001), Hovawart (HW1706), Kunming Dog (KM1), Kunming Dog (KM2), Kunming Dog (KM3), Kunming Dog (KM4), Kunming Dog (KM6), Kunming Dog (KM7), Labrador Retriever (LA1869), Labrador Retriever (LA2382), Labrador Retriever (LA900), Leonberger (LB1919), Chinese indigenous dogs (LJ1), Chinese indigenous dogs (LJ10), Chinese indigenous dogs (LJ2), Chinese indigenous dogs (LJ4), Chinese indigenous dogs (LJ5), Chinese indigenous dogs (LJ6), Chinese indigenous dogs (LJ7), Chinese indigenous dogs (LJ8), Lagotto Romagnolo (LR1030), Lagotto Romagnolo (LR390), Lagotto Romagnolo (LR433), Lagotto Romagnolo (LR538), Lagotto Romagnolo (LR654), Lagotto Romagnolo (LR753), Malinois (MA324), Sloughi (SG005), Sloughi (SG006), Sloughi (SG008), Cavalier King Charles Spaniel (SID00101), Great Lakes Wolf (SRS661486), Iranian Wolf (SRS661488), Portuguese Wolf (SRS661492), Spanish Wolf (SRS661495), Yellowstone Wolf (SRS661496), Border Terrier (SRS932144), Alaskan Husky (SY001), Alaskan Husky (SY018), Tibetan Mastiff (TM4), Tibetan Mastiff (TM5), Tibetan Mastiff (TM6), Tibetan Mastiff (TM9), Weimaraner (WE006), Weimaraner (WE008), Wolf (WO001_895), Wolf (WO002_732), Chinese indigenous dogs (YJ1), Chinese indigenous dogs (YJ3), Chinese indigenous dogs (YJ4), Chinese indigenous dogs (YJ6)
17 51716179 51716180 G A snv Chinese indigenous dogs (YJ9)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009277 Ensembl
NCBI Gene DCLRE1B ENTREZGENE
UniProt E2RLH4 ENTREZGENE
VGNC ID VGNC:39807 ENTREZGENE