Mir26a (microRNA 26a) - Rat Genome Database

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Gene: Mir26a (microRNA 26a) Rattus norvegicus
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Symbol: Mir26a
Name: microRNA 26a
RGD ID: 2325337
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including enzyme-linked receptor protein signaling pathway; regulation of cell migration; and regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular response to mechanical stimulus; long-term synaptic potentiation; and negative regulation of macromolecule metabolic process. Predicted to be located in extracellular exosome. Predicted to be part of RISC complex. Orthologous to human MIR26A1 (microRNA 26a-1); INTERACTS WITH aflatoxin B1; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-26a; rno-mir-26a
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,633,048 - 127,633,137 (+)NCBIGRCr8
mRatBN7.28118,755,289 - 118,755,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,755,289 - 118,755,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,356,957 - 124,357,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,555,905 - 122,555,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,388,622 - 120,388,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,714,441 - 127,714,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,714,441 - 127,714,530 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,931,592 - 126,931,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8117,928,870 - 117,928,959 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
embryo implantation  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
response to bacterium  (ISO)
response to wounding  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3ß Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model. Park H, etal., Yonsei Med J. 2018 Aug;59(6):736-745. doi: 10.3349/ymj.2018.59.6.736.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:18556655   PMID:18762567   PMID:20403161   PMID:21141477   PMID:22210897   PMID:23254997   PMID:23719092   PMID:23783805  
PMID:24205035   PMID:24423102   PMID:25047835   PMID:25797045   PMID:25858512   PMID:25959411   PMID:27075111   PMID:27485101   PMID:27874055   PMID:28429763   PMID:29391491   PMID:29917203  
PMID:29932234   PMID:30118880   PMID:30132885   PMID:30652345   PMID:30964179   PMID:31264214   PMID:31267533   PMID:31313025   PMID:31486509   PMID:31990056   PMID:32196616   PMID:32492799  
PMID:32622424   PMID:32779957   PMID:33423166   PMID:33820561   PMID:34228643   PMID:34438336   PMID:34518647   PMID:34544974   PMID:36210702   PMID:36434679   PMID:36948295   PMID:37788453  
PMID:38172711   PMID:38430034  


Genomics

Comparative Map Data
Mir26a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,633,048 - 127,633,137 (+)NCBIGRCr8
mRatBN7.28118,755,289 - 118,755,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,755,289 - 118,755,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,356,957 - 124,357,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,555,905 - 122,555,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,388,622 - 120,388,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,714,441 - 127,714,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,714,441 - 127,714,530 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,931,592 - 126,931,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8117,928,870 - 117,928,959 (+)NCBICelera
Cytogenetic Map8q32NCBI
MIR26A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38337,969,404 - 37,969,480 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl337,969,404 - 37,969,480 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,010,895 - 38,010,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,985,898 - 37,985,974 (+)NCBINCBI36Build 36hg18NCBI36
Celera337,945,267 - 37,945,343 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef337,953,581 - 37,953,657 (+)NCBIHuRef
CHM1_1337,962,544 - 37,962,620 (+)NCBICHM1_1
T2T-CHM13v2.0337,973,584 - 37,973,660 (+)NCBIT2T-CHM13v2.0
Mir26a-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,860,864 - 118,860,953 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,860,864 - 118,860,953 (+)EnsemblGRCm39 Ensembl
GRCm389119,031,796 - 119,031,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,031,796 - 119,031,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv379118,940,914 - 118,941,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9119,499,693 - 119,499,782 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.32NCBI
MIR26A-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,747,073 - 7,747,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,747,064 - 7,747,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,788,996 - 7,789,056 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,036,042 - 8,036,102 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,036,033 - 8,036,109 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1237,850,472 - 7,850,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0237,991,571 - 7,991,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,983,727 - 7,983,787 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Map2rno-miR-26a-5pMirtarbaseexternal_infoWestern blotFunctional MTI17592044

Predicted Targets
Summary Value
Count of predictions:7832
Count of gene targets:4964
Count of transcripts:5321
Interacting mature miRNAs:rno-miR-26a-3p, rno-miR-26a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
BE105202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28118,754,535 - 118,754,699 (+)MAPPERmRatBN7.2
Rnor_6.08127,713,688 - 127,713,851NCBIRnor6.0
Rnor_5.08126,930,839 - 126,931,002UniSTSRnor5.0
RGSC_v3.48123,980,866 - 123,981,029UniSTSRGSC3.4
Celera8117,928,117 - 117,928,280UniSTS
RH 3.4 Map81311.5UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 12 62 20 25 8 7 8 3 64 29 51 22 35 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,755,289 - 118,755,378 (+)Ensembl
Rnor_6.0 Ensembl8127,714,441 - 127,714,530 (+)Ensembl
RefSeq Acc Id: NR_031830
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,633,048 - 127,633,137 (+)NCBI
mRatBN7.28118,755,289 - 118,755,378 (+)NCBI
Rnor_6.08127,714,441 - 127,714,530 (+)NCBI
Rnor_5.08126,931,592 - 126,931,681 (+)NCBI
Celera8117,928,870 - 117,928,959 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325337 AgrOrtholog
BioCyc Gene G2FUF-28810 BioCyc
Ensembl Genes ENSRNOG00000035582 Ensembl
miRBase MI0000857 ENTREZGENE
NCBI Gene 100314290 ENTREZGENE
PhenoGen Mir26a PhenoGen
RatGTEx ENSRNOG00000035582 RatGTEx
RNAcentral URS000019B0F7 RNACentral
  URS000075B819 RNACentral
  URS000075C23C RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-15 Mir26a  microRNA 26a  Mir26a  microRNA mir-26a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir26a  microRNA mir-26a      Symbol and Name status set to provisional 70820 PROVISIONAL