Phlpp2 (PH domain and leucine rich repeat protein phosphatase 2) - Rat Genome Database

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Gene: Phlpp2 (PH domain and leucine rich repeat protein phosphatase 2) Rattus norvegicus
Analyze
Symbol: Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
RGD ID: 1562857
Description: Enables protein serine/threonine phosphatase activity. Involved in hippocampus development. Located in photoreceptor inner segment and photoreceptor outer segment membrane. Orthologous to human PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498949; PH domain and leucine rich repeat protein phosphatase-like; PH domain leucine-rich repeat-containing protein phosphatase 2; Phlppl; RGD1562857; similar to KIAA0931 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,744,581 - 54,811,258 (+)NCBIGRCr8
mRatBN7.21937,835,125 - 37,901,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,647,457 - 44,714,119 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,300,799 - 45,367,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,610,415 - 47,677,073 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,731,845 - 41,798,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,555,245 - 52,621,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,741,655 - 39,808,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1937,238,682 - 37,305,396 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PHLiPPing the switch on Akt and protein kinase C signaling. Brognard J and Newton AC, Trends Endocrinol Metab. 2008 Aug;19(6):223-30. Epub 2008 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PHLPP1 splice variants differentially regulate AKT and PKCalpha signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. Jackson TC, etal., J Neurochem. 2010 Nov;115(4):941-55. doi: 10.1111/j.1471-4159.2010.06984.x. Epub 2010 Sep 28.
4. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. Kanan Y, etal., J Neurochem. 2010 Apr;113(2):477-88. Epub 2010 Jan 20.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Signaling specificity in the Akt pathway in biology and disease. Toker A and Marmiroli S, Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001. Epub 2014 Apr 19.
Additional References at PubMed
PMID:19450723   PMID:24675471   PMID:26286854   PMID:29628444  


Genomics

Comparative Map Data
Phlpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,744,581 - 54,811,258 (+)NCBIGRCr8
mRatBN7.21937,835,125 - 37,901,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,647,457 - 44,714,119 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,300,799 - 45,367,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,610,415 - 47,677,073 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,731,845 - 41,798,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,555,245 - 52,621,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,741,655 - 39,808,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1937,238,682 - 37,305,396 (+)NCBICelera
Cytogenetic Map19q12NCBI
PHLPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,644,924 - 71,724,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,637,835 - 71,724,701 (-)EnsemblGRCh38hg38GRCh38
GRCh371671,678,827 - 71,758,604 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,236,353 - 70,306,205 (-)NCBINCBI36Build 36hg18NCBI36
Celera1655,994,913 - 56,064,759 (-)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,446,695 - 57,516,253 (-)NCBIHuRef
CHM1_11673,091,614 - 73,161,535 (-)NCBICHM1_1
T2T-CHM13v2.01677,462,088 - 77,541,847 (-)NCBIT2T-CHM13v2.0
Phlpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,595,149 - 110,671,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,595,174 - 110,671,303 (+)EnsemblGRCm39 Ensembl
GRCm388109,868,517 - 109,944,671 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,868,542 - 109,944,671 (+)EnsemblGRCm38mm10GRCm38
MGSCv378112,392,503 - 112,468,571 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,757,671 - 112,830,037 (+)NCBIMGSCv36mm8
Celera8114,090,251 - 114,166,622 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.33NCBI
Phlpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,353,950 - 4,420,873 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,353,950 - 4,419,891 (-)NCBIChiLan1.0ChiLan1.0
PHLPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,436,073 - 82,514,656 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,363,906 - 88,445,484 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,287,549 - 53,366,113 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,481,605 - 71,562,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,481,605 - 71,562,793 (-)Ensemblpanpan1.1panPan2
PHLPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,428,587 - 77,506,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,432,517 - 77,565,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,394,012 - 77,467,228 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0577,871,556 - 77,945,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl577,869,730 - 78,028,575 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,691,632 - 77,765,295 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,514,784 - 77,588,272 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,013,711 - 78,087,473 (-)NCBIUU_Cfam_GSD_1.0
Phlpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,450,806 - 37,514,518 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647522,074,568 - 22,138,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647522,074,620 - 22,138,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,633,751 - 14,715,965 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,633,756 - 14,715,921 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PHLPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1554,767,935 - 54,845,700 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl554,767,941 - 54,845,527 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604717,569,921 - 17,646,703 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phlpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474613,919,557 - 13,994,182 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474613,917,070 - 13,994,212 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phlpp2
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:54
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000021744
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
RH136743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,851,821 - 37,851,973 (-)MAPPERmRatBN7.2
Rnor_6.01941,781,596 - 41,781,747NCBIRnor6.0
Rnor_5.01952,604,996 - 52,605,147UniSTSRnor5.0
RGSC_v3.41939,758,352 - 39,758,503UniSTSRGSC3.4
Celera1937,255,465 - 37,255,616UniSTS
Cytogenetic Map19q12UniSTS
RH130264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,886,653 - 37,886,865 (-)MAPPERmRatBN7.2
Rnor_6.01941,746,783 - 41,746,994NCBIRnor6.0
Rnor_5.01952,570,183 - 52,570,394UniSTSRnor5.0
RGSC_v3.41939,793,151 - 39,793,362UniSTSRGSC3.4
Celera1937,290,248 - 37,290,459UniSTS
RH 3.4 Map19427.6UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6 28 20 9 20 74 29 35 3
Low 2 36 29 21 10 21 8 11 6 6 8 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021744   ⟹   ENSRNOP00000021745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)Ensembl
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101587   ⟹   ENSRNOP00000085796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,866,645 - 37,905,513 (+)Ensembl
RefSeq Acc Id: NM_001109131   ⟹   NP_001102601
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,744,581 - 54,811,258 (+)NCBI
mRatBN7.21937,835,125 - 37,901,804 (+)NCBI
Rnor_6.01941,731,845 - 41,798,451 (-)NCBI
Rnor_5.01952,555,245 - 52,621,851 (-)NCBI
RGSC_v3.41939,741,655 - 39,808,301 (+)RGD
Celera1937,238,682 - 37,305,396 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102601 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021745
  ENSRNOP00000021745.7
  ENSRNOP00000085796.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102601   ⟸   NM_001109131
- UniProtKB: D4A254 (UniProtKB/TrEMBL),   A6IZ38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021745   ⟸   ENSRNOT00000021744
RefSeq Acc Id: ENSRNOP00000085796   ⟸   ENSRNOT00000101587
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A254-F1-model_v2 AlphaFold D4A254 1-1190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701133
Promoter ID:EPDNEW_R11657
Type:initiation region
Name:Phlpp2_1
Description:PH domain and leucine rich repeat protein phosphatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01941,798,398 - 41,798,458EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562857 AgrOrtholog
BioCyc Gene G2FUF-5704 BioCyc
Ensembl Genes ENSRNOG00000016108 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021744 ENTREZGENE
  ENSRNOT00000021744.7 UniProtKB/TrEMBL
  ENSRNOT00000101587.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  PP2C-related UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
KEGG Report rno:498949 UniProtKB/TrEMBL
NCBI Gene 498949 ENTREZGENE
PANTHER PTHR48051 UniProtKB/TrEMBL
  ZGC:77287 UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  PP2C UniProtKB/TrEMBL
PhenoGen Phlpp2 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016108 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  PP2C-related UniProtKB/TrEMBL
UniProt A0A8I6A0Z2_RAT UniProtKB/TrEMBL
  A6IZ38 ENTREZGENE, UniProtKB/TrEMBL
  D4A254 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Phlpp2  PH domain and leucine rich repeat protein phosphatase 2  Phlppl  PH domain and leucine rich repeat protein phosphatase-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Phlppl  PH domain and leucine rich repeat protein phosphatase-like  RGD1562857_predicted  similar to KIAA0931 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562857_predicted  similar to KIAA0931 protein (predicted)  LOC498949  similar to KIAA0931 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498949  similar to KIAA0931 protein      Symbol and Name status set to provisional 70820 PROVISIONAL