PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2) - Rat Genome Database

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Gene: PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2) Sus scrofa
Analyze
Symbol: PHLPP2
Name: PH domain and leucine rich repeat protein phosphatase 2
RGD ID: 13916205
Description: ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN hippocampus development (ortholog); protein dephosphorylation (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: PH domain leucine-rich repeat-containing protein phosphatase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,633,751 - 14,715,965 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,633,756 - 14,715,921 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
PHLPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,633,751 - 14,715,965 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,633,756 - 14,715,921 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PHLPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,644,924 - 71,724,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,637,835 - 71,724,701 (-)EnsemblGRCh38hg38GRCh38
GRCh371671,678,827 - 71,758,604 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,236,353 - 70,306,205 (-)NCBINCBI36Build 36hg18NCBI36
Celera1655,994,913 - 56,064,759 (-)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,446,695 - 57,516,253 (-)NCBIHuRef
CHM1_11673,091,614 - 73,161,535 (-)NCBICHM1_1
T2T-CHM13v2.01677,462,088 - 77,541,847 (-)NCBIT2T-CHM13v2.0
Phlpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,595,149 - 110,671,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,595,174 - 110,671,303 (+)EnsemblGRCm39 Ensembl
GRCm388109,868,517 - 109,944,671 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,868,542 - 109,944,671 (+)EnsemblGRCm38mm10GRCm38
MGSCv378112,392,503 - 112,468,571 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,757,671 - 112,830,037 (+)NCBIMGSCv36mm8
Celera8114,090,251 - 114,166,622 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.33NCBI
Phlpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,744,581 - 54,811,258 (+)NCBIGRCr8
mRatBN7.21937,835,125 - 37,901,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,647,457 - 44,714,119 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,300,799 - 45,367,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,610,415 - 47,677,073 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,731,845 - 41,798,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,555,245 - 52,621,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,741,655 - 39,808,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1937,238,682 - 37,305,396 (+)NCBICelera
Cytogenetic Map19q12NCBI
Phlpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,353,950 - 4,420,873 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,353,950 - 4,419,891 (-)NCBIChiLan1.0ChiLan1.0
PHLPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,436,073 - 82,514,656 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,363,906 - 88,445,484 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,287,549 - 53,366,113 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,481,605 - 71,562,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,481,605 - 71,562,793 (-)Ensemblpanpan1.1panPan2
PHLPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,428,587 - 77,506,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,432,517 - 77,565,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,394,012 - 77,467,228 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0577,871,556 - 77,945,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl577,869,730 - 78,028,575 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,691,632 - 77,765,295 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,514,784 - 77,588,272 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,013,711 - 78,087,473 (-)NCBIUU_Cfam_GSD_1.0
Phlpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,450,806 - 37,514,518 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647522,074,568 - 22,138,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647522,074,620 - 22,138,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1554,767,935 - 54,845,700 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl554,767,941 - 54,845,527 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604717,569,921 - 17,646,703 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phlpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474613,919,557 - 13,994,182 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474613,917,070 - 13,994,212 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PHLPP2
2352 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5
Low 10 4 3 5 2 18 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003035   ⟹   ENSSSCP00000002956
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl614,633,751 - 14,715,825 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000024128   ⟹   ENSSSCP00000023509
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl614,633,751 - 14,715,965 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000032306   ⟹   ENSSSCP00000022425
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl614,633,751 - 14,715,892 (-)Ensembl
RefSeq Acc Id: XM_021093823   ⟹   XP_020949482
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,633,756 - 14,715,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093824   ⟹   XP_020949483
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,633,756 - 14,710,194 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093825   ⟹   XP_020949484
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,633,756 - 14,715,892 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020949482   ⟸   XM_021093823
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SM23 (UniProtKB/TrEMBL),   I3LHG3 (UniProtKB/TrEMBL),   A0A480L5V2 (UniProtKB/TrEMBL),   A0A480Z482 (UniProtKB/TrEMBL),   A0A8D1R584 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949484   ⟸   XM_021093825
- Peptide Label: isoform X3
- UniProtKB: A0A8D0Q4Y2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949483   ⟸   XM_021093824
- Peptide Label: isoform X2
- UniProtKB: A0A8D1ET25 (UniProtKB/TrEMBL),   A0A8D1I612 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002956   ⟸   ENSSSCT00000003035
RefSeq Acc Id: ENSSSCP00000022425   ⟸   ENSSSCT00000032306
RefSeq Acc Id: ENSSSCP00000023509   ⟸   ENSSSCT00000024128
Protein Domains
PH   PPM-type phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002739 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015077435 UniProtKB/TrEMBL
  ENSSSCG00030070529 UniProtKB/TrEMBL
  ENSSSCG00035069622 UniProtKB/TrEMBL
  ENSSSCG00040048040 UniProtKB/TrEMBL
  ENSSSCG00045024024 UniProtKB/TrEMBL
  ENSSSCG00050015188 UniProtKB/TrEMBL
  ENSSSCG00055019689 UniProtKB/TrEMBL
  ENSSSCG00060042408 UniProtKB/TrEMBL
  ENSSSCG00065035885 UniProtKB/TrEMBL
  ENSSSCG00070002282 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003035.4 UniProtKB/TrEMBL
  ENSSSCT00000024128 ENTREZGENE
  ENSSSCT00000024128.4 UniProtKB/TrEMBL
  ENSSSCT00015104610.1 UniProtKB/TrEMBL
  ENSSSCT00030098722.1 UniProtKB/TrEMBL
  ENSSSCT00030098794.1 UniProtKB/TrEMBL
  ENSSSCT00035094038.1 UniProtKB/TrEMBL
  ENSSSCT00040064875.1 UniProtKB/TrEMBL
  ENSSSCT00040065029.1 UniProtKB/TrEMBL
  ENSSSCT00045041054.1 UniProtKB/TrEMBL
  ENSSSCT00050020604.1 UniProtKB/TrEMBL
  ENSSSCT00050020624.1 UniProtKB/TrEMBL
  ENSSSCT00055038579.1 UniProtKB/TrEMBL
  ENSSSCT00055038767.1 UniProtKB/TrEMBL
  ENSSSCT00055038924.1 UniProtKB/TrEMBL
  ENSSSCT00060057504.1 UniProtKB/TrEMBL
  ENSSSCT00060057511.1 UniProtKB/TrEMBL
  ENSSSCT00060057525.1 UniProtKB/TrEMBL
  ENSSSCT00065048904.1 UniProtKB/TrEMBL
  ENSSSCT00070004280.1 UniProtKB/TrEMBL
  ENSSSCT00070004289.1 UniProtKB/TrEMBL
  ENSSSCT00070004311.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
NCBI Gene PHLPP2 ENTREZGENE
PANTHER NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  PP2C UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF81606 UniProtKB/TrEMBL
UniProt A0A480L5V2 ENTREZGENE, UniProtKB/TrEMBL
  A0A480Z482 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SLY7_PIG UniProtKB/TrEMBL
  A0A4X1SM23 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SNF6_PIG UniProtKB/TrEMBL
  A0A8D0Q4Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y0L6_PIG UniProtKB/TrEMBL
  A0A8D1ET25 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1I612 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R584 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R5W5_PIG UniProtKB/TrEMBL
  A0A8D1RBT9_PIG UniProtKB/TrEMBL
  F1S3C8_PIG UniProtKB/TrEMBL
  H9LBM1_PIG UniProtKB/TrEMBL
  I3LHG3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:98186 ENTREZGENE