INTERLEUKIN-10 SIGNALING PATHWAY (PW:0000515)
Description
Interleukin-10 (Il-10) is a prominent member of the interleukin 10 family of cytokines which also includes interleukin 28A, 28B and 29 known as interferon type III or lambda. In addition to the mammalian proteins, several viral homologues are also known. The many biological actions of Il-10 impinge upon the release of immune mediators and antigen presentation with an overall anti-inflammatory effect; interestingly it is Il-10 and not the other members of the family that appear to promote such effects. Il10 acts primarily on monocytes/macrophages keeping a balance between the responses of T helper (Th)1 and Th2 cell. More specifically, it inhibits the release of pro-inflammatory mediators, suppressing Th1 responses while stimulating the Th2 ones. The broad spectrum of biological effects Il10 exerts, relies on the coordinated regulation of expression of hundreds of genes. Expression experiments point to ~1,600 up-regulated and ~1,300 down-regulated genes as a result of Il10 signaling which engages the Jak-Stat intracellular pathway. There are two Il10 receptors - Il10ra and Il10rb; Il10ra is primarily expressed in immune cells whereas the expression of Il10rb is ubiquitous. Unlike Il10ra which is specific for Il10, Il10rb is part of receptor complexes for other members of the interleukin-10 family. Upon binding to Il10ra, the cytokine undergoes conformational changes that facilitate the association of Il-10/Il10ra complex with Il10rb; by itself, Il10rb is unable to associate with Il10. The Il-10/Il10-receptors complex activates members of the Janus kinase family: Jak1, which associates with Il10ra and Tyk2 which associates with Il10rb. Subsequently, the kinases phosphorylate two tyrosine residues in Il10ra resulting in the recruitment of Stat3 via its SH2 (
src homology 2 ) domain followed by its own Jak-mediated phosphorylation. Stat1, and in some cell types Stat5 can also be activated in response to Il10. Activated homo- and heterodimers of Stat translocate to the nucleus to regulate the transcription of many genes, including Socs3 which binds to and inhibits the activity of Jak kinases and may mediate the termination of Il10 effects. Stat3 is also essential for the expression of Il10 downstream of pro-inflammatory cytokines such as 1l-6 and Il-12 (with other Stats also contributing). Pathogenic microorganisms can also induce Il-10 downstream of Toll-like receptors (TLR) such as Tlr2; many TLRs are targets for Il-10 mediated suppression. At times, pathogens mediate Il10 induction to use the production of selected cytokines as a virulence strategy to promote their survival within the host. Interestingly, despite intense research on the Il10 system, the molecular mechanisms underlying its many biological actions remain elusive. For instance, how does a C-terminal region achieve its crucial role in the inhibition of release of pro-inflammatory mediators or what are the roles played by other kinases which Il10 activates - are among the questions still awaiting answers.
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Pathway Diagram:
Genes in Pathway:
G
Il10
interleukin 10
ISO IMP
RGD
PMID:15032600 PMID:21115385 PMID:19428551 RGD:1580494 , RGD:5688379 , RGD:2311043
NCBI chr13:45,024,921...45,029,586
G
Il10ra
interleukin 10 receptor subunit alpha
ISO IMP
RGD
PMID:21115385 PMID:19428551 RGD:5688379 , RGD:2311043
NCBI chr 8:54,459,754...54,474,786
G
Il10rb
interleukin 10 receptor subunit beta
ISO
RGD
PMID:21115385 RGD:5688379
NCBI chr11:44,132,471...44,154,062
G
Jak1
Janus kinase 1
ISO
RGD
PMID:21115385 RGD:5688379
NCBI chr 5:120,895,606...121,004,207
G
Stat1
signal transducer and activator of transcription 1
ISO
RGD
PMID:21115385 RGD:5688379
NCBI chr 9:56,911,522...56,951,926
G
Stat3
signal transducer and activator of transcription 3
ISO IMP
RGD
PMID:21115385 PMID:19428551 RGD:5688379 , RGD:2311043
NCBI chr10:86,311,528...86,363,513
G
Tyk2
tyrosine kinase 2
ISO
RGD
PMID:21115385 RGD:5688379
NCBI chr 8:27,918,054...27,943,319
Pathway Gene Annotations
Disease Annotations Associated with Genes in the Interleukin-10 signaling pathway
Il10 abdominal aortic aneurysm , Actinic Cheilitis , Acute Experimental Pancreatitis , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute lymphoblastic leukemia , acute myeloid leukemia , acute myocardial infarction , acute pancreatitis , adult respiratory distress syndrome , adult T-cell leukemia/lymphoma , aggressive periodontitis , Airway Obstruction , alcohol use disorder , allergic conjunctivitis , allergic contact dermatitis , allergic rhinitis , Alveolar Bone Loss , Alzheimer's disease , anemia , Animal Disease Models , anogenital venereal wart , anti-basement membrane glomerulonephritis , aphthous stomatitis , appendicitis , arteriosclerosis , Asthenopia , asthma , atherosclerosis , atopic dermatitis , autistic disorder , autoimmune hemolytic anemia , autoimmune hepatitis , autoimmune thrombocytopenic purpura , B-Cell Chronic Lymphocytic Leukemia , bacterial infectious disease , bacterial pneumonia , Behcet's disease , Brain Injuries , Breast Neoplasms , Bronchial Hyperreactivity , bronchus carcinoma , Burns , carotid artery disease , carotid stenosis , celiac disease , central nervous system lymphoma , cerebral infarction , cervical cancer , Chagas Cardiomyopathy , Chemically-Induced Disorders , choroid disease , Choroidal Neovascularization , Chronic Bronchitis , Chronic Hepatitis C , chronic myeloid leukemia , Chronic Periodontitis , colitis , colon cancer , common cold , congestive heart failure , coronary artery disease , Coronavirus infectious disease , COVID-19 , Crohn's disease , cutaneous leishmaniasis , cytomegalovirus retinitis , decubitus ulcer , diabetes mellitus , Diabetic Cardiomyopathies , Diabetic Nephropathies , diabetic retinopathy , diffuse scleroderma , dilated cardiomyopathy , disseminated intravascular coagulation , drug allergy , Drug-Related Side Effects and Adverse Reactions , dry eye syndrome , Dysbiosis , Dyspepsia , Eales Disease , endometrial cancer , endometriosis , Endotoxemia , Entamoebiasis , Enterocolitis , Enterovirus Infections , esophageal cancer , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Autoimmune Uveitis , Experimental Autoimmune Uveoretinitis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Eye Burns , factor VIII deficiency , Fanconi anemia , Femoral Fractures , gallbladder carcinoma , gastric dilatation , Gastro-Enteropancreatic Neuroendocrine Tumor , Genetic Predisposition to Disease , gestational diabetes , glomerulonephritis , glucosephosphate dehydrogenase deficiency , graft-versus-host disease , granulomatosis with polyangiitis , Graves ophthalmopathy , Graves' disease , Hearing Loss , Heat Stroke , Hemorrhagic Shock , Heparin-induced Thrombocytopenia , hepatitis B , hepatitis C , hepatocellular carcinoma , herpes simplex virus keratitis , herpes zoster , high grade glioma , Hodgkin's lymphoma , human immunodeficiency virus infectious disease , Human Influenza , Human Viral Hepatitis , Hyperalgesia , hypertension , hyperthyroidism , hypothyroidism , ileitis , Immediate Hypersensitivity , Inflammation , inflammatory bowel disease , intermediate uveitis , intestinal obstruction , irritable bowel syndrome , Kidney Reperfusion Injury , leishmaniasis , lip cancer , liver benign neoplasm , liver cancer , liver carcinoma , liver cirrhosis , Liver Reperfusion Injury , lung disease , Lung Neoplasms , lung non-small cell carcinoma , lymphoplasmacytic lymphoma , major depressive disorder , Malignant Pleural Effusions , metabolic dysfunction-associated steatohepatitis , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , Middle East respiratory syndrome , mitral valve stenosis , mucositis , multiple myeloma , Multiple Organ Failure , multiple sclerosis , Murine Acquired Immunodeficiency Syndrome , myocardial infarction , Myocardial Reperfusion Injury , myocarditis , Nasal Polyps , Neoplasm Metastasis , Neuralgia , obesity , obstructive sleep apnea , occupational dermatitis , Ocular Toxoplasmosis , ocular tuberculosis , open-angle glaucoma , oral squamous cell carcinoma , otitis media , ovarian cancer , pancreatic cancer , panuveitis , Penetrating Wounds , pericardial effusion , perinatal necrotizing enterocolitis , periodontitis , Plaque, Atherosclerotic , plasmacytoma , pleurisy , pneumonia , postpartum depression , Pregnancy-associated Malaria , primary biliary cholangitis , Primary Graft Dysfunction , Prostatic Neoplasms , prostatitis , Pseudomonas Aeruginosa Keratitis , psoriasis , pulmonary eosinophilia , pulmonary hypertension , Reperfusion Injury , respiratory allergy , respiratory syncytial virus infectious disease , retinal artery occlusion , retinal disease , retinopathy of prematurity , Retroviridae Infections , rheumatic heart disease , rheumatoid arthritis , Rhinosinusitis , schizophrenia , sciatic neuropathy , Seasonal Allergic Rhinitis , Sepsis , severe acute respiratory syndrome , shigellosis , Shwartzman phenomenon , sickle cell anemia , Sjogren's syndrome , skin disease , Spinal Cord Injuries , Splenomegaly , Staphylococcal Infections , Staphylococcal Pneumonia , steatotic liver disease , stomach cancer , stroke , systemic lupus erythematosus , thrombocytopenia , thrombosis , thyrotoxicosis , tongue squamous cell carcinoma , toxic encephalopathy , toxic shock syndrome , Toxoplasma Chorioretinitis , trachoma , transient cerebral ischemia , Transplant Rejection , trichinosis , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , uveitis , vasculitis , Venous Thrombosis , Ventilator-Induced Lung Injury , viral pneumonia , visceral leishmaniasis , Weight Loss , Wilson disease , Wounds and Injuries Il10ra COVID-19 , Crohn's disease , Experimental Autoimmune Encephalomyelitis , genetic disease , inflammatory bowel disease , inflammatory bowel disease 28 , visceral leishmaniasis Il10rb brain ischemia , COVID-19 , graft-versus-host disease , hepatitis B , inflammatory bowel disease 25 , perinatal necrotizing enterocolitis Jak1 Acute Experimental Pancreatitis , Autoinflammation, Immune Dysregulation, and Eosinophilia , Chronic Hepatitis B , colorectal cancer , endometrial cancer , Experimental Arthritis , genetic disease , hepatocellular carcinoma , Hypoxia , liver cirrhosis , lung non-small cell carcinoma , lupus nephritis , myeloid leukemia associated with Down Syndrome , ovarian cancer , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , periodontitis , prostate cancer , Prostatic Neoplasms , sciatic neuropathy , stomach cancer , systemic lupus erythematosus , T-cell acute lymphoblastic leukemia , transient cerebral ischemia Stat1 angiomyolipoma , Brain Injuries , breast cancer , breast carcinoma , chronic mucocutaneous candidiasis , colon adenocarcinoma , COVID-19 , Cytomegalovirus Infections , Disease Progression , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , gastric adenocarcinoma , genetic disease , Hearing Loss , hepatitis C , hepatocellular carcinoma , Human Influenza , immunodeficiency 31A , immunodeficiency 31B , immunodeficiency 31C , liver cirrhosis , lupus nephritis , lymphangioleiomyomatosis , lymphocytic choriomeningitis , Mycobacterium Infections , Myocardial Reperfusion Injury , Neoplasm Metastasis , nephroblastoma , Nervous System Trauma , Nontuberculous Mycobacterium Infections , pancreatic adenocarcinoma , periodontitis , primary immunodeficiency disease , prostate adenocarcinoma , pulmonary fibrosis , Reoviridae Infections , Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , severe acute respiratory syndrome , T-cell acute lymphoblastic leukemia Stat3 acute myeloid leukemia , adenocarcinoma , adult T-cell leukemia/lymphoma , alcohol use disorder , Alzheimer's disease , anaplastic large cell lymphoma , angiomyolipoma , angiosarcoma , Animal Disease Models , Animal Mammary Neoplasms , atherosclerosis , Atrophy , autistic disorder , autoimmune disease , autosomal dominant hyper-IgE syndrome 1 with recurrent infections , B-lymphoblastic leukemia/lymphoma , bacterial pneumonia , Behcet's disease , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , carcinoma , Cardiomegaly , cardiomyopathy , cervix uteri carcinoma in situ , Chemical and Drug Induced Liver Injury , Choroidal Neovascularization , Chronic Hepatitis , Chronic Hepatitis C , chronic lymphocytic leukemia , Churg-Strauss syndrome , colon adenocarcinoma , colon cancer , Colonic Neoplasms , colorectal cancer , colorectal carcinoma , congenital diaphragmatic hernia , congestive heart failure , Copper-Overload Cirrhosis , Crohn's disease , depressive disorder , Desbuquois dysplasia , Diabetic Nephropathies , diffuse large B-cell lymphoma , duodenal ulcer , Endometrial Neoplasms , Epidermal Hyperplasia , esophageal carcinoma , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Uveitis , Experimental Autoimmune Uveoretinitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Fever , Fibrosis , follicular dendritic cell sarcoma , gastric adenocarcinoma , genetic disease , glioblastoma , head and neck squamous cell carcinoma , heart disease , hepatocellular carcinoma , hyper IgE syndrome , Hyperalgesia , hyperuricemia , idiopathic pulmonary fibrosis , infantile onset multisystem autoimmune disease 1 , Inflammation , inflammatory bowel disease , irritant dermatitis , juvenile rheumatoid arthritis , liver cirrhosis , Liver Injury , Liver Neoplasms , Lung Neoplasms , lung non-small cell carcinoma , lymphangioleiomyomatosis , Lymphatic Metastasis , lymphoproliferative syndrome , medulloblastoma , Memory Disorders , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , Myocardial Reperfusion Injury , Nasal Polyps , nasal type extranodal NK/T-cell lymphoma , nasopharynx carcinoma , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , neutropenia , Niemann-Pick disease type C1 , obesity , ovarian cancer , Ovarian Neoplasms , Oxygen-Induced Retinopathy , pancreatic cancer , periodontitis , peripartum cardiomyopathy , pre-malignant neoplasm , primary immunodeficiency disease , prostate cancer , prostate carcinoma , Prostatic Neoplasms , psoriasis , psoriatic arthritis , pulmonary fibrosis , pulmonary hypertension , Pulmonary Hypertension, Hypoxia-Induced , Pyogenic Granuloma , rectum adenocarcinoma , renal cell carcinoma , Reperfusion Injury , Retina Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , Sepsis-Associated Encephalopathy , skin melanoma , Skin Neoplasms , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Subarachnoid Hemorrhage , T-cell acute lymphoblastic leukemia , T-cell non-Hodgkin lymphoma , Tongue Neoplasms , transient cerebral ischemia , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , urinary bladder cancer , Uterine Cervical Neoplasms Tyk2 autistic disorder , Cocaine-Related Disorders , COVID-19 , Crohn's disease , genetic disease , immunodeficiency 35 , multiple sclerosis , obesity , Paranoid Disorders , primary biliary cholangitis , psoriasis , rheumatoid arthritis , T-cell acute lymphoblastic leukemia , type 1 diabetes mellitus
abdominal aortic aneurysm Il10 Actinic Cheilitis Il10 Acute Experimental Pancreatitis Il10 , Jak1 acute kidney failure Il10 Acute Liver Failure Il10 Acute Lung Injury Il10 acute lymphoblastic leukemia Il10 acute myeloid leukemia Il10 , Stat3 acute myocardial infarction Il10 acute pancreatitis Il10 adenocarcinoma Stat3 adult respiratory distress syndrome Il10 adult T-cell leukemia/lymphoma Il10 , Stat3 aggressive periodontitis Il10 Airway Obstruction Il10 alcohol use disorder Il10 , Stat3 allergic conjunctivitis Il10 allergic contact dermatitis Il10 allergic rhinitis Il10 Alveolar Bone Loss Il10 Alzheimer's disease Il10 , Stat3 anaplastic large cell lymphoma Stat3 anemia Il10 angiomyolipoma Stat1 , Stat3 angiosarcoma Stat3 Animal Disease Models Il10 , Stat3 Animal Mammary Neoplasms Stat3 anogenital venereal wart Il10 anti-basement membrane glomerulonephritis Il10 aphthous stomatitis Il10 appendicitis Il10 arteriosclerosis Il10 Asthenopia Il10 asthma Il10 atherosclerosis Il10 , Stat3 atopic dermatitis Il10 Atrophy Stat3 autistic disorder Il10 , Stat3 , Tyk2 autoimmune disease Stat3 autoimmune hemolytic anemia Il10 autoimmune hepatitis Il10 autoimmune thrombocytopenic purpura Il10 Autoinflammation, Immune Dysregulation, and Eosinophilia Jak1 autosomal dominant hyper-IgE syndrome 1 with recurrent infections Stat3 B-Cell Chronic Lymphocytic Leukemia Il10 B-lymphoblastic leukemia/lymphoma Stat3 bacterial infectious disease Il10 bacterial pneumonia Il10 , Stat3 Behcet's disease Il10 , Stat3 Brain Injuries Il10 , Stat1 , Stat3 brain ischemia Il10rb , Stat3 breast cancer Stat1 , Stat3 breast carcinoma Stat1 Breast Neoplasms Il10 , Stat3 Bronchial Hyperreactivity Il10 bronchus carcinoma Il10 Burns Il10 carcinoma Stat3 Cardiomegaly Stat3 cardiomyopathy Stat3 carotid artery disease Il10 carotid stenosis Il10 celiac disease Il10 central nervous system lymphoma Il10 cerebral infarction Il10 cervical cancer Il10 cervix uteri carcinoma in situ Stat3 Chagas Cardiomyopathy Il10 Chemical and Drug Induced Liver Injury Stat3 Chemically-Induced Disorders Il10 choroid disease Il10 Choroidal Neovascularization Il10 , Stat3 Chronic Bronchitis Il10 Chronic Hepatitis Stat3 Chronic Hepatitis B Jak1 Chronic Hepatitis C Il10 , Stat3 chronic lymphocytic leukemia Stat3 chronic mucocutaneous candidiasis Stat1 chronic myeloid leukemia Il10 Chronic Periodontitis Il10 Churg-Strauss syndrome Stat3 Cocaine-Related Disorders Tyk2 colitis Il10 colon adenocarcinoma Stat1 , Stat3 colon cancer Il10 , Stat3 Colonic Neoplasms Stat3 colorectal cancer Jak1 , Stat3 colorectal carcinoma Stat3 common cold Il10 congenital diaphragmatic hernia Stat3 congestive heart failure Il10 , Stat3 Copper-Overload Cirrhosis Stat3 coronary artery disease Il10 Coronavirus infectious disease Il10 COVID-19 Il10 , Il10ra , Il10rb , Stat1 , Tyk2 Crohn's disease Il10 , Il10ra , Stat3 , Tyk2 cutaneous leishmaniasis Il10 Cytomegalovirus Infections Stat1 cytomegalovirus retinitis Il10 decubitus ulcer Il10 depressive disorder Stat3 Desbuquois dysplasia Stat3 diabetes mellitus Il10 Diabetic Cardiomyopathies Il10 Diabetic Nephropathies Il10 , Stat3 diabetic retinopathy Il10 diffuse large B-cell lymphoma Stat3 diffuse scleroderma Il10 dilated cardiomyopathy Il10 Disease Progression Stat1 disseminated intravascular coagulation Il10 drug allergy Il10 Drug-Related Side Effects and Adverse Reactions Il10 dry eye syndrome Il10 duodenal ulcer Stat3 Dysbiosis Il10 Dyspepsia Il10 Eales Disease Il10 endometrial cancer Il10 , Jak1 Endometrial Neoplasms Stat3 endometriosis Il10 Endotoxemia Il10 Entamoebiasis Il10 Enterocolitis Il10 Enterovirus Infections Il10 Epidermal Hyperplasia Stat3 esophageal cancer Il10 esophageal carcinoma Stat3 Experimental Arthritis Il10 , Jak1 , Stat1 , Stat3 Experimental Autoimmune Encephalomyelitis Il10 , Il10ra , Stat1 , Stat3 Experimental Autoimmune Myocarditis Il10 Experimental Autoimmune Uveitis Il10 , Stat3 Experimental Autoimmune Uveoretinitis Il10 , Stat3 Experimental Colitis Il10 Experimental Diabetes Mellitus Il10 , Stat1 , Stat3 Experimental Liver Cirrhosis Il10 , Stat3 Experimental Liver Neoplasms Stat3 Experimental Mammary Neoplasms Il10 , Stat1 , Stat3 Experimental Neoplasms Stat3 Experimental Radiation Injuries Il10 Eye Burns Il10 factor VIII deficiency Il10 Fanconi anemia Il10 Femoral Fractures Il10 Fever Stat3 Fibrosis Stat3 follicular dendritic cell sarcoma Stat3 gallbladder carcinoma Il10 gastric adenocarcinoma Stat1 , Stat3 gastric dilatation Il10 Gastro-Enteropancreatic Neuroendocrine Tumor Il10 genetic disease Il10ra , Jak1 , Stat1 , Stat3 , Tyk2 Genetic Predisposition to Disease Il10 gestational diabetes Il10 glioblastoma Stat3 glomerulonephritis Il10 glucosephosphate dehydrogenase deficiency Il10 graft-versus-host disease Il10 , Il10rb granulomatosis with polyangiitis Il10 Graves ophthalmopathy Il10 Graves' disease Il10 head and neck squamous cell carcinoma Stat3 Hearing Loss Il10 , Stat1 heart disease Stat3 Heat Stroke Il10 Hemorrhagic Shock Il10 Heparin-induced Thrombocytopenia Il10 hepatitis B Il10 , Il10rb hepatitis C Il10 , Stat1 hepatocellular carcinoma Il10 , Jak1 , Stat1 , Stat3 herpes simplex virus keratitis Il10 herpes zoster Il10 high grade glioma Il10 Hodgkin's lymphoma Il10 human immunodeficiency virus infectious disease Il10 Human Influenza Il10 , Stat1 Human Viral Hepatitis Il10 hyper IgE syndrome Stat3 Hyperalgesia Il10 , Stat3 hypertension Il10 hyperthyroidism Il10 hyperuricemia Stat3 hypothyroidism Il10 Hypoxia Jak1 idiopathic pulmonary fibrosis Stat3 ileitis Il10 Immediate Hypersensitivity Il10 immunodeficiency 31A Stat1 immunodeficiency 31B Stat1 immunodeficiency 31C Stat1 immunodeficiency 35 Tyk2 infantile onset multisystem autoimmune disease 1 Stat3 Inflammation Il10 , Stat3 inflammatory bowel disease Il10 , Il10ra , Stat3 inflammatory bowel disease 25 Il10rb inflammatory bowel disease 28 Il10ra intermediate uveitis Il10 intestinal obstruction Il10 irritable bowel syndrome Il10 irritant dermatitis Stat3 juvenile rheumatoid arthritis Stat3 Kidney Reperfusion Injury Il10 leishmaniasis Il10 lip cancer Il10 liver benign neoplasm Il10 liver cancer Il10 liver carcinoma Il10 liver cirrhosis Il10 , Jak1 , Stat1 , Stat3 Liver Injury Stat3 Liver Neoplasms Stat3 Liver Reperfusion Injury Il10 lung disease Il10 Lung Neoplasms Il10 , Stat3 lung non-small cell carcinoma Il10 , Jak1 , Stat3 lupus nephritis Jak1 , Stat1 lymphangioleiomyomatosis Stat1 , Stat3 Lymphatic Metastasis Stat3 lymphocytic choriomeningitis Stat1 lymphoplasmacytic lymphoma Il10 lymphoproliferative syndrome Stat3 major depressive disorder Il10 Malignant Pleural Effusions Il10 medulloblastoma Stat3 Memory Disorders Stat3 metabolic dysfunction-associated steatohepatitis Il10 metabolic dysfunction-associated steatotic liver disease Il10 , Stat3 middle cerebral artery infarction Il10 , Stat3 Middle East respiratory syndrome Il10 mitral valve stenosis Il10 mucositis Il10 multiple myeloma Il10 Multiple Organ Failure Il10 multiple sclerosis Il10 , Tyk2 Murine Acquired Immunodeficiency Syndrome Il10 Mycobacterium Infections Stat1 myeloid leukemia associated with Down Syndrome Jak1 myocardial infarction Il10 Myocardial Reperfusion Injury Il10 , Stat1 , Stat3 myocarditis Il10 Nasal Polyps Il10 , Stat3 nasal type extranodal NK/T-cell lymphoma Stat3 nasopharynx carcinoma Stat3 Neoplasm Invasiveness Stat3 Neoplasm Metastasis Il10 , Stat1 , Stat3 Neoplastic Cell Transformation Stat3 nephroblastoma Stat1 , Stat3 Nervous System Trauma Stat1 Neuralgia Il10 neutropenia Stat3 Niemann-Pick disease type C1 Stat3 Nontuberculous Mycobacterium Infections Stat1 obesity Il10 , Stat3 , Tyk2 obstructive sleep apnea Il10 occupational dermatitis Il10 Ocular Toxoplasmosis Il10 ocular tuberculosis Il10 open-angle glaucoma Il10 oral squamous cell carcinoma Il10 otitis media Il10 ovarian cancer Il10 , Jak1 , Stat3 Ovarian Neoplasms Stat3 Oxygen-Induced Retinopathy Stat3 pancreatic adenocarcinoma Jak1 , Stat1 pancreatic cancer Il10 , Stat3 pancreatic ductal adenocarcinoma Jak1 panuveitis Il10 Paranoid Disorders Tyk2 Penetrating Wounds Il10 pericardial effusion Il10 perinatal necrotizing enterocolitis Il10 , Il10rb periodontitis Il10 , Jak1 , Stat1 , Stat3 peripartum cardiomyopathy Stat3 Plaque, Atherosclerotic Il10 plasmacytoma Il10 pleurisy Il10 pneumonia Il10 postpartum depression Il10 pre-malignant neoplasm Stat3 Pregnancy-associated Malaria Il10 primary biliary cholangitis Il10 , Tyk2 Primary Graft Dysfunction Il10 primary immunodeficiency disease Stat1 , Stat3 prostate adenocarcinoma Stat1 prostate cancer Jak1 , Stat3 prostate carcinoma Stat3 Prostatic Neoplasms Il10 , Jak1 , Stat3 prostatitis Il10 Pseudomonas Aeruginosa Keratitis Il10 psoriasis Il10 , Stat3 , Tyk2 psoriatic arthritis Stat3 pulmonary eosinophilia Il10 pulmonary fibrosis Stat1 , Stat3 pulmonary hypertension Il10 , Stat3 Pulmonary Hypertension, Hypoxia-Induced Stat3 Pyogenic Granuloma Stat3 rectum adenocarcinoma Stat3 renal cell carcinoma Stat3 Reoviridae Infections Stat1 Reperfusion Injury Il10 , Stat1 , Stat3 respiratory allergy Il10 respiratory syncytial virus infectious disease Il10 Retina Reperfusion Injury Stat3 retinal artery occlusion Il10 retinal disease Il10 retinopathy of prematurity Il10 Retroviridae Infections Il10 rheumatic heart disease Il10 rheumatoid arthritis Il10 , Stat1 , Stat3 , Tyk2 Rhinosinusitis Il10 schizophrenia Il10 sciatic neuropathy Il10 , Jak1 scrapie Stat1 , Stat3 Seasonal Allergic Rhinitis Il10 Sepsis Il10 , Stat1 , Stat3 Sepsis-Associated Encephalopathy Stat3 severe acute respiratory syndrome Il10 , Stat1 shigellosis Il10 Shwartzman phenomenon Il10 sickle cell anemia Il10 Sjogren's syndrome Il10 skin disease Il10 skin melanoma Stat3 Skin Neoplasms Stat3 Spinal Cord Injuries Il10 Splenomegaly Il10 squamous cell carcinoma Stat3 Staphylococcal Infections Il10 Staphylococcal Pneumonia Il10 steatotic liver disease Il10 stomach cancer Il10 , Jak1 , Stat3 Stomach Neoplasms Stat3 stroke Il10 Subarachnoid Hemorrhage Stat3 systemic lupus erythematosus Il10 , Jak1 T-cell acute lymphoblastic leukemia Jak1 , Stat1 , Stat3 , Tyk2 T-cell non-Hodgkin lymphoma Stat3 thrombocytopenia Il10 thrombosis Il10 thyrotoxicosis Il10 Tongue Neoplasms Stat3 tongue squamous cell carcinoma Il10 toxic encephalopathy Il10 toxic shock syndrome Il10 Toxoplasma Chorioretinitis Il10 trachoma Il10 transient cerebral ischemia Il10 , Jak1 , Stat3 Transplant Rejection Il10 trichinosis Il10 type 1 diabetes mellitus Il10 , Stat3 , Tyk2 type 2 diabetes mellitus Il10 , Stat3 ulcerative colitis Il10 , Stat3 urinary bladder cancer Stat3 Uterine Cervical Neoplasms Stat3 uveitis Il10 vasculitis Il10 Venous Thrombosis Il10 Ventilator-Induced Lung Injury Il10 viral pneumonia Il10 visceral leishmaniasis Il10 , Il10ra Weight Loss Il10 Wilson disease Il10 Wounds and Injuries Il10
