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Term:granulomatosis with polyangiitis
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Accession:DOID:12132 term browser browse the term
Definition:A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.
Synonyms:exact_synonym: WG;   Wegener granulomatosis;   Wegener granulomatosis, formerly;   Wegener's granulomatosis;   Wegener's syndrome;   granulomatosis with polyangiitides;   necrotizing respiratory granulomatosis
 primary_id: MESH:D014890
 alt_id: OMIM:608710;   RDO:0004587
 xref: GARD:7880;   ICD10CM:M31.3;   ICD10CM:M31.30;   ICD9CM:446.4;   NCI:C3444
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granulomatosis with polyangiitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr3 C-C motif chemokine receptor 3 JBrowse link 8 133,026,539 133,040,999 RGD:4145634
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:4892114
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6893495
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:5490596
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:7204724
G Fcar Fc fragment of IgA receptor JBrowse link 1 73,230,392 73,263,462 RGD:7242064
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:8548880
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1580480
G Prtn3 proteinase 3 JBrowse link 7 12,643,712 12,646,951 RGD:11554173
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:5684985
G Vtn vitronectin JBrowse link 10 65,767,960 65,771,040 RGD:1580817

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15502
    sensory system disease 4663
      skin disease 2467
        granulomatosis with polyangiitis 11
          Midline Granulomatosis 0
          Wegener-Like Granulomatosis 0
Path 2
Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      cardiovascular system disease 4237
        vascular disease 3277
          vasculitis 149
            Systemic Vasculitis 44
              Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 30
                granulomatosis with polyangiitis 11
                  Midline Granulomatosis 0
                  Wegener-Like Granulomatosis 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.