RGD Reference Report - Regulation of interleukin-10 and interleukin-22 expression in T helper cells. - Rat Genome Database

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Regulation of interleukin-10 and interleukin-22 expression in T helper cells.

Authors: Rutz, S  Ouyang, W 
Citation: Rutz S and Ouyang W, Curr Opin Immunol. 2011 Oct;23(5):605-12. Epub 2011 Aug 20.
RGD ID: 6478710
Pubmed: PMID:21862302   (View Abstract at PubMed)
DOI: DOI:10.1016/j.coi.2011.07.018   (Journal Full-text)

Interleukin (IL)-10 and IL-22 are crucial regulators of inflammation during immune responses. While IL-10 functions to prevent excessive inflammation by acting on immune cells, IL-22 elicits innate responses from tissue epithelia and promotes wound healing. Although T helper (Th) cells are a major source for both cytokines, IL-10 and IL-22 are rarely co-expressed at high levels in the same cells. Here we discuss a number of common aspects as well as crucial differences in the molecular regulation of both cytokines that might explain their broad, but distinct expression among Th cell subsets.


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