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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:fibroblast growth factor signaling pathway
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Accession:PW:0000328 term browser browse the term
Definition:The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and it relies on the Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
Synonyms:related_synonym: FGF signaling pathway;   Signaling by FGFR
 alt_id: PID:200220;   Reactome:R-HSA-190236


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fibroblast growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200220 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO PID PID:200220 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200220 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200220 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cdh1 cadherin 1 ISO PID PID:200220 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 ISO PID PID:200220 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ctnnd1 catenin delta 1 ISO PID PID:200220 NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049
JBrowse link
G Cttn cortactin ISO PID PID:200220 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO PID PID:200220 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf17 fibroblast growth factor 17 ISO PID PID:200220 NCBI chr15:52,326,758...52,337,360
Ensembl chr15:52,326,778...52,332,097
JBrowse link
G Fgf18 fibroblast growth factor 18 ISO PID PID:200220 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf19 fibroblast growth factor 19 ISO PID PID:200220 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO PID PID:200220 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf23 fibroblast growth factor 23 ISO PID PID:200220 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Fgf4 fibroblast growth factor 4 ISO PID PID:200220 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Fgf6 fibroblast growth factor 6 ISO PID PID:200220 NCBI chr 4:159,563,798...159,572,333
Ensembl chr 4:159,563,798...159,572,333
JBrowse link
G Fgf8 fibroblast growth factor 8 ISO PID PID:200220 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fgf9 fibroblast growth factor 9 IDA
ISO
PID PMID:15231666 PID:200220, RGD:1304345 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO PID PID:200220 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IMP
ISO
PID PMID:15292181 PID:200220, RGD:2289848 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 IDA RGD PMID:15231666 RGD:1304345 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO PID PID:200220 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200220 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 ISO PID PID:200220 NCBI chr 7:60,128,506...60,210,482
Ensembl chr 7:60,128,508...60,210,518
JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200220 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200220 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Hgf hepatocyte growth factor ISO PID PID:200220 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Il17rd interleukin 17 receptor D ISO PID PID:200220 NCBI chr16:2,670,471...2,737,271
Ensembl chr16:2,670,618...2,731,808
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200220 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kl Klotho ISO RGD PMID:16436388 RGD:1581599 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Klb klotho beta ISO PID PID:200220 NCBI chr14:44,529,523...44,614,093 JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200220 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200220 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO PID PID:200220 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO PID PID:200220 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO PID PID:200220 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 ISO PID PID:200220 NCBI chr 1:85,162,462...85,201,746
Ensembl chr 1:85,162,452...85,201,757
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200220 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200220 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200220 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plau plasminogen activator, urokinase ISO PID PID:200220 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO PID PID:200220 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200220 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200220 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200220 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO PID PID:200220 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO PID PID:200220 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sdc2 syndecan 2 ISO PID PID:200220 NCBI chr 7:71,572,731...71,686,139
Ensembl chr 7:71,572,941...71,686,044
JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200220 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200220 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO PID PID:200220 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 ISO PID PID:200220 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200220 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Ssh1 slingshot protein phosphatase 1 ISO PID PID:200220 NCBI chr12:48,403,184...48,447,964
Ensembl chr12:48,403,797...48,446,977
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200220 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO PID PID:200220 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link

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  pathway 6106
    signaling pathway 2647
      growth factor signaling pathway 523
        fibroblast growth factor signaling pathway 56
          altered fibroblast growth factor signaling pathway + 0
          endocrine fibroblast growth factor signaling pathway + 0
          intracrine fibroblast growth factor signaling pathway + 0
          paracrine fibroblast growth factor signaling pathway + 0
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