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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:fibroblast growth factor signaling pathway
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Accession:PW:0000328 term browser browse the term
Definition:The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and it relies on the Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
Synonyms:related_synonym: FGF signaling pathway;   Signaling by FGFR
 alt_id: PID:200220;   Reactome:R-HSA-190236

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fibroblast growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200220 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO PID PID:200220 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200220 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200220 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722 		JBrowse link
G Cdh1 cadherin 1 ISO PID PID:200220 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh2 cadherin 2 ISO PID PID:200220 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Ctnnd1 catenin delta 1 ISO PID PID:200220 NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049 		JBrowse link
G Cttn cortactin ISO PID PID:200220 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152 		JBrowse link
G Fgf1 fibroblast growth factor 1 ISO PID PID:200220 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf17 fibroblast growth factor 17 ISO PID PID:200220 NCBI chr15:52,326,758...52,337,360
Ensembl chr15:52,326,778...52,332,097 		JBrowse link
G Fgf18 fibroblast growth factor 18 ISO PID PID:200220 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391 		JBrowse link
G Fgf19 fibroblast growth factor 19 ISO PID PID:200220 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO PID PID:200220 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fgf23 fibroblast growth factor 23 ISO PID PID:200220 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082 		JBrowse link
G Fgf4 fibroblast growth factor 4 ISO PID PID:200220 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220 		JBrowse link
G Fgf6 fibroblast growth factor 6 ISO PID PID:200220 NCBI chr 4:159,563,798...159,572,333
Ensembl chr 4:159,563,798...159,572,333 		JBrowse link
G Fgf8 fibroblast growth factor 8 ISO PID PID:200220 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831 		JBrowse link
G Fgf9 fibroblast growth factor 9 IDA
ISO		 PID PMID:15231666 PID:200220, RGD:1304345 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO PID PID:200220 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IMP
ISO		 PID PMID:15292181 PID:200220, RGD:2289848 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 IDA RGD PMID:15231666 RGD:1304345 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO PID PID:200220 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200220 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 ISO PID PID:200220 NCBI chr 7:60,128,506...60,210,482
Ensembl chr 7:60,128,508...60,210,518 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200220 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200220 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071 		JBrowse link
G Hgf hepatocyte growth factor ISO PID PID:200220 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Il17rd interleukin 17 receptor D ISO PID PID:200220 NCBI chr16:2,670,471...2,737,271
Ensembl chr16:2,670,618...2,731,808 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200220 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kl Klotho ISO RGD PMID:16436388 RGD:1581599 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551 		JBrowse link
G Klb klotho beta ISO PID PID:200220 NCBI chr14:44,529,523...44,614,093 JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200220 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200220 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO PID PID:200220 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO PID PID:200220 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO PID PID:200220 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358 		JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 ISO PID PID:200220 NCBI chr 1:85,162,462...85,201,746
Ensembl chr 1:85,162,452...85,201,757 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200220 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200220 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200220 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Plau plasminogen activator, urokinase ISO PID PID:200220 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO PID PID:200220 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200220 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200220 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200220 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO PID PID:200220 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO PID PID:200220 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Sdc2 syndecan 2 ISO PID PID:200220 NCBI chr 7:71,572,731...71,686,139
Ensembl chr 7:71,572,941...71,686,044 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200220 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200220 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO PID PID:200220 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 ISO PID PID:200220 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200220 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Ssh1 slingshot protein phosphatase 1 ISO PID PID:200220 NCBI chr12:48,403,184...48,447,964
Ensembl chr12:48,403,797...48,446,977 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200220 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO PID PID:200220 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6106
    signaling pathway 2647
      growth factor signaling pathway 523
        fibroblast growth factor signaling pathway 56
          altered fibroblast growth factor signaling pathway + 0
          endocrine fibroblast growth factor signaling pathway + 0
          intracrine fibroblast growth factor signaling pathway + 0
          paracrine fibroblast growth factor signaling pathway + 0
paths to the root